EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr18	49785244	Silent	novel	L354L	0.24
BLCA	chr18	49795778	Missense_Mutation	novel	G139E	0.3
BLCA	chr18	49814166	5'Flank	novel		0.17
BRCA	chr18	49813878	5'UTR	novel		0.38
BRCA	chr18	49791545	Nonsense_Mutation	novel	K270*	0.14
BRCA	chr18	49791546	Missense_Mutation	novel	K269N	0.15
BRCA	chr18	49802829	Missense_Mutation	NA	R14L	0.12
BRCA	chr18	49785279	Missense_Mutation	NA	V343M	0.28
CESC	chr18	49802853	Missense_Mutation	novel	G6A	0.1
CESC	chr18	49794359	Silent	novel	E166E	0.4
CESC	chr18	49783861	Nonsense_Mutation	NA	Q394*	0.38
CESC	chr18	49813645	5'UTR	novel		0.3
CESC	chr18	49813888	5'UTR	novel		0.18
COAD	chr18	49787349	Missense_Mutation	NA	A299V	0.28
COAD	chr18	49802810	Silent	rs151022375	Y20Y	0.3
COAD	chr18	49792245	Silent	rs754463910	D220D	0.28
ESCA	chr18	49802811	Frame_Shift_Ins	novel	*Y20Lfs12**	0.32
ESCA	chr18	49785330	Missense_Mutation	novel	Q326K	0.29
GBM	chr18	49814374	5'Flank	novel		0.29
GBM	chr18	49797595	Splice_Site	novel	X62_splice	0.18
HNSC	chr18	49797562	Missense_Mutation	novel	H72Q	0.25
HNSC	chr18	49814195	5'Flank	novel		0.13
LGG	chr18	49802832	Missense_Mutation	novel	K13R	0.54
LGG	chr18	49783930	Missense_Mutation	rs771012528	R371C	0.37
LGG	chr18	49802822	Silent	novel	P16P	0.15
LGG	chr18	49785333	Missense_Mutation	rs763895191	P325S	0.15
LIHC	chr18	49802827	Missense_Mutation	novel	T15A	0.3
LIHC	chr18	49783818	3'UTR	novel		0.08
LUAD	chr18	49814227	5'Flank	novel		0.12
LUAD	chr18	49791501	Silent	NA	V284V	0.31
LUAD	chr18	49802823	Missense_Mutation	NA	P16R	0.2
LUSC	chr18	49814085	5'Flank	novel		0.22
LUSC	chr18	49794411	Missense_Mutation	novel	W149S	0.18
MESO	chr18	49792231	Missense_Mutation	rs765105322	P225L	0.38
OV	chr18	49814304	5'Flank	novel		0.22
OV	chr18	49814113	5'Flank	novel		0.14
OV	chr18	49783929	Missense_Mutation	NA	R371P	0.35
READ	chr18	49785204	Missense_Mutation	rs745865904	E368K	0.11
READ	chr18	49783719	3'UTR	novel		0.29
SKCM	chr18	49794424	Missense_Mutation	novel	E145K	0.12
SKCM	chr18	49791480	Silent	NA	I291I	0.05
SKCM	chr18	49794300	Missense_Mutation	rs762428287	S186L	0.24
SKCM	chr18	49791527	Silent	NA	L276L	0.34
SKCM	chr18	49814195	5'Flank	novel		0.58
STAD	chr18	49814330	5'Flank	novel		0.1
STAD	chr18	49795856	Missense_Mutation	NA	V113A	0.37
STAD	chr18	49791589	Missense_Mutation	novel	D255G	0.09
STAD	chr18	49791553	Missense_Mutation	novel	A267V	0.05
STAD	chr18	49794347	Silent	NA	V170V	0.08
STAD	chr18	49814026	5'Flank	novel		0.5
STAD	chr18	49797552	Missense_Mutation	rs145076043	R76C	0.2
STAD	chr18	49791470	Missense_Mutation	novel	G295R	0.46
STAD	chr18	49785266	Missense_Mutation	NA	A347V	0.13
STAD	chr18	49802830	Nonsense_Mutation	rs769900666	R14*	0.26
UCEC	chr18	49795831	Silent	rs774699358	S121S	0.33
UCEC	chr18	49792195	Missense_Mutation	novel	P237L	0.27
UCEC	chr18	49814083	5'Flank	novel		0.42
UCEC	chr18	49792272	Missense_Mutation	novel	K211N	0.3
UCEC	chr18	49813624	5'UTR	novel		0.59
UCEC	chr18	49791553	Missense_Mutation	novel	A267D	0.09
UCEC	chr18	49791557	Missense_Mutation	novel	D266Y	0.35
UCEC	chr18	49813542	5'UTR	novel		0.55
UCEC	chr18	49814363	5'Flank	rs374539906		0.37
UCEC	chr18	49792153	Missense_Mutation	rs748770671	S251L	0.66
UCEC	chr18	49785196	Splice_Site	rs147811299	X370_splice	0.3
UCEC	chr18	49797486	Missense_Mutation	NA	S98P	0.4
UCEC	chr18	49813794	5'UTR	novel		0.34
UCEC	chr18	49785335	Missense_Mutation	novel	A324V	0.21
UCEC	chr18	49794408	Missense_Mutation	novel	V150A	0.42
UCEC	chr18	49814125	5'Flank	novel		0.49
UCEC	chr18	49797485	Missense_Mutation	novel	S98F	0.4
UCEC	chr18	49795877	Missense_Mutation	novel	I106N	0.06
UCEC	chr18	49802826	Missense_Mutation	rs777732630	T15M	0.33
UCEC	chr18	49795871	Missense_Mutation	NA	V108A	0.28
UCEC	chr18	49783553	3'UTR	novel		0.2
UCEC	chr18	49814064	5'Flank	NA		0.12

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LIHC	DEL	0.2378	0.019373
UCEC	DEL	0.141	0.006131
UCS	DEL	0.3571	0.12533

Survival Analysis

Cancer	P-value	Q-value
THYM	0.049	Kaplan-Meier Survival Analysis
UCS	0.0017	Kaplan-Meier Survival Analysis
KIRP	0.00012	Kaplan-Meier Survival Analysis
COAD	0.014	Kaplan-Meier Survival Analysis
CESC	0.0093	Kaplan-Meier Survival Analysis
UCEC	0.0067	Kaplan-Meier Survival Analysis
GBM	0.0018	Kaplan-Meier Survival Analysis
LIHC	0.032	Kaplan-Meier Survival Analysis
DLBC	0.036	Kaplan-Meier Survival Analysis
LGG	0.00016	Kaplan-Meier Survival Analysis
OV	0.008	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000167315 (Gene tree)
Gene ID: 10449
Gene Symbol: ACAA2
Alias: DSAEC
Full Name: acetyl-CoA acyltransferase 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 31,794 bases
Position: chr18:49,782,167-49,813,960
Accession: 83
RBP type: non-canonical RBP
Summary: The encoded protein catalyzes the last step of the mitochondrial fatty acid beta-oxidation spiral. Unlike most mitochondrial matrix proteins, it contains a non-cleavable amino-terminal targeting signal. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
29458450	Transcriptomic and metabolomic responses induced in the livers of growing pigs by a short-term intravenous infusion of sodium butyrate.	Animal	2018 Nov	Ren E	doi: 10.1017/S1751731118000174

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000285093	ACAA2-201	3350	-	ENSP00000285093	397 (aa)	-	P42765
ENST00000586100	ACAA2-203	639	-	ENSP00000468157	72 (aa)	-	K7ER88
ENST00000591171	ACAA2-207	1850	-	-	- (aa)	-	-
ENST00000586485	ACAA2-204	727	-	ENSP00000465045	124 (aa)	-	K7EJ68
ENST00000587994	ACAA2-205	1657	-	ENSP00000466015	394 (aa)	-	A0A0B4J2A4
ENST00000585948	ACAA2-202	538	-	ENSP00000465095	84 (aa)	-	K7EJB1
ENST00000589432	ACAA2-206	1840	-	ENSP00000466466	342 (aa)	-	K7EME0

Gene Model

Click here to download ENSG00000167315's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00062	Fatty acid elongation	KEGG
hsa00071	Fatty acid degradation	KEGG
hsa00280	Valine, leucine and isoleucine degradation	KEGG
hsa01100	Metabolic pathways	KEGG
hsa01212	Fatty acid metabolism	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000167315	rs617619	18	49801659	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000167315's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000167315	ACAA2	99	32.787	WBGene00015125	B0303.3	94	32.787	Caenorhabditis_elegans
ENSG00000167315	ACAA2	100	65.882	FBgn0040064	yip2	99	59.494	Drosophila_melanogaster
ENSG00000167315	ACAA2	99	44.501	FBgn0035203	CG9149	99	44.501	Drosophila_melanogaster
ENSG00000167315	ACAA2	99	32.009	FBgn0025352	Thiolase	90	31.935	Drosophila_melanogaster
ENSG00000167315	ACAA2	99	41.349	ENSG00000075239	ACAT1	91	40.204	Homo_sapiens
ENSG00000167315	ACAA2	99	34.038	ENSG00000138029	HADHB	93	34.033	Homo_sapiens
ENSG00000167315	ACAA2	99	39.420	ENSMUSG00000036138	Acaa1a	90	38.481	Mus_musculus
ENSG00000167315	ACAA2	99	33.566	ENSMUSG00000059447	Hadhb	89	33.566	Mus_musculus
ENSG00000167315	ACAA2	99	42.254	YPL028W	ERG10	99	37.845	Saccharomyces_cerevisiae
ENSG00000167315	ACAA2	99	37.870	YIL160C	POT1	91	36.203	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0003985	acetyl-CoA C-acetyltransferase activity	21873635.	IBA	Function
GO:0003988	acetyl-CoA C-acyltransferase activity	21873635.	IBA	Function
GO:0003988	acetyl-CoA C-acyltransferase activity	8241273.	NAS	Function
GO:0005515	protein binding	18371312.	IPI	Function
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005739	mitochondrion	18371312.	IDA	Component
GO:0005739	mitochondrion	8241273.	NAS	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0006635	fatty acid beta-oxidation	21873635.	IBA	Process
GO:0006635	fatty acid beta-oxidation	-	TAS	Process
GO:0006695	cholesterol biosynthetic process	8241273.	NAS	Process
GO:0071456	cellular response to hypoxia	18371312.	IDA	Process
GO:1901029	negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	18371312.	IDA	Process
GO:1902109	negative regulation of mitochondrial membrane permeability involved in apoptotic process	18371312.	IDA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.