EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26366712	Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis.	Nat Med	2015 Oct	Zhang J	doi: 10.1038/nm.3940
25112956	Exome sequencing identifies frequent mutation of MLL2 in non-small cell lung carcinoma from Chinese patients.	Sci Rep	2014 Aug 12	Yin S	doi: 10.1038/srep06036.
26366710	The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development.	Nat Med	2015 Oct	Ortega-Molina A	doi: 10.1038/nm.3943
29532228	High MLL2 expression predicts poor prognosis and promotes tumor progression by inducing EMT in esophageal squamous cell carcinoma.	J Cancer Res Clin Oncol	2018 Jun	Abudureheman A	doi: 10.1007/s00432-018-2625-5
29627316	KMT2D Mutation Is Associated With Poor Prognosis in Non-Small-Cell Lung Cancer.	Clin Lung Cancer	2018 Jul	Ardeshir-Larijani F	doi: 10.1016/j.cllc.2018.03.005
16603732	Identification of the MLL2 complex as a coactivator for estrogen receptor alpha.	J Biol Chem	2006 Jun 9	Mo R	-
24491801	UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells.	Cancer Res	2014 Mar 15	Kim JH	doi: 10.1158/0008-5472.CAN-13-1896
20937768	Pygo2 associates with MLL2 histone methyltransferase and GCN5 histone acetyltransferase complexes to augment Wnt target gene expression and breast cancer stem-like cell expansion.	Mol Cell Biol	2010 Dec	Chen J	doi: 10.1128/MCB.00465-10
28336670	PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D.	Science	2017 Mar 24	Toska E	doi: 10.1126/science.aah6893.
28007623	Small Cell Lung Cancer Exhibits Frequent Inactivating Mutations in the Histone Methyltransferase KMT2D/MLL2: CALGB 151111 (Alliance).	J Thorac Oncol	2017 Apr	Augert A	doi: 10.1016/j.jtho.2016.12.011
27387124	Single-cell Sequencing Reveals Variants in ARID1A, GPRC5A and MLL2 Driving Self-renewal of Human Bladder Cancer Stem Cells.	Eur Urol	2017 Jan	Yang Z	doi: 10.1016/j.eururo.2016.06.025
29269867	Histone methyltransferase KMT2D sustains prostate carcinogenesis and metastasis via epigenetically activating LIFR and KLF4.	Oncogene	2018 Mar	Lv S	doi: 10.1038/s41388-017-0026-x
30177394	Downregulation of KMT2D suppresses proliferation and induces apoptosis of gastric cancer.	Biochem Biophys Res Commun	2018 Sep 26	Xiong W	doi: 10.1016/j.bbrc.2018.08.143

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr12	49051423	Missense_Mutation	novel	P754A	0.25
ACC	chr12	49022643	Missense_Mutation	novel	T5429A	0.12
ACC	chr12	49043922	Silent	novel	Q1755Q	0.44
ACC	chr12	49027846	Missense_Mutation	novel	Y4867C	0.25
ACC	chr12	49051769	Silent	novel	P638P	0.72
ACC	chr12	49040709	Frame_Shift_Del	NA	*P2354Lfs30**	0.59
ACC	chr12	49026390	Silent	rs779137584	L5192L	0.49
BLCA	chr12	49050383	Nonsense_Mutation	novel	E1069*	0.14
BLCA	chr12	49051252	Nonsense_Mutation	novel	E811*	0.09
BLCA	chr12	49026764	Missense_Mutation	novel	E5068K	0.35
BLCA	chr12	49049727	Silent	novel	E1287E	0.22
BLCA	chr12	49034174	Nonsense_Mutation	novel	K3545*	0.32
BLCA	chr12	49052961	Nonsense_Mutation	NA	Q356*	0.28
BLCA	chr12	49050536	Nonsense_Mutation	NA	E1018*	0.41
BLCA	chr12	49037954	Silent	novel	F3134F	0.42
BLCA	chr12	49051149	Frame_Shift_Ins	rs767415197	*R845Pfs3**	0.27
BLCA	chr12	49052579	Nonsense_Mutation	NA	E415*	0.24
BLCA	chr12	49039434	Splice_Site	novel	X2743_splice	0.4
BLCA	chr12	49034146	Frame_Shift_Del	novel	G3553*	0.41
BLCA	chr12	49049851	Missense_Mutation	rs112921115	T1246M	0.52
BLCA	chr12	49051287	Frame_Shift_Del	novel	*P799Lfs131**	0.49
BLCA	chr12	49053073	Splice_Site	NA	X319_splice	0.32
BLCA	chr12	49051569	Nonsense_Mutation	novel	S705*	0.1
BLCA	chr12	49051974	Missense_Mutation	NA	S570C	0.07
BLCA	chr12	49027883	Missense_Mutation	novel	D4855H	0.44
BLCA	chr12	49028142	Splice_Site	NA	X4795_splice	0.31
BLCA	chr12	49029232	Nonsense_Mutation	novel	E4694*	0.43
BLCA	chr12	49030343	Missense_Mutation	novel	E4646K	0.43
BLCA	chr12	49053287	Missense_Mutation	novel	E292K	0.13
BLCA	chr12	49026431	Missense_Mutation	rs794727688	R5179C	0.58
BLCA	chr12	49039311	Frame_Shift_Del	novel	*I2760Sfs27**	0.44
BLCA	chr12	49040838	Missense_Mutation	novel	S2311F	0.42
BLCA	chr12	49042179	Nonsense_Mutation	novel	E2007*	0.21
BLCA	chr12	49040778	Frame_Shift_Del	novel	F2327*	0.32
BLCA	chr12	49021845	Missense_Mutation	novel	E5517Q	0.37
BLCA	chr12	49026381	Silent	novel	Q5195Q	0.37
BLCA	chr12	49031315	Nonsense_Mutation	NA	Q4464*	0.42
BLCA	chr12	49032033	Frame_Shift_Ins	novel	*L4225Tfs109**	0.1
BLCA	chr12	49050608	Nonsense_Mutation	novel	E994*	0.15
BLCA	chr12	49051387	Missense_Mutation	novel	E766K	0.1
BLCA	chr12	49041035	Silent	NA	L2245L	0.25
BLCA	chr12	49027307	Nonsense_Mutation	rs793888513	E4887*	0.2
BLCA	chr12	49039582	Missense_Mutation	novel	Q2694H	0.21
BLCA	chr12	49047968	Silent	novel	S1411S	0.19
BLCA	chr12	49051603	Missense_Mutation	novel	E694K	0.15
BLCA	chr12	49054564	Missense_Mutation	novel	E122K	0.27
BLCA	chr12	49032572	Nonsense_Mutation	novel	Q4045*	0.53
BLCA	chr12	49039221	Splice_Site	novel	X2789_splice	0.17
BLCA	chr12	49053038	Nonsense_Mutation	novel	S330*	0.04
BLCA	chr12	49049964	Missense_Mutation	novel	I1208M	0.39
BLCA	chr12	49026337	Missense_Mutation	novel	Y5210S	0.33
BLCA	chr12	49031921	Nonsense_Mutation	NA	Q4262*	0.14
BLCA	chr12	49033850	Missense_Mutation	novel	L3619F	0.47
BLCA	chr12	49044840	Missense_Mutation	rs754087735	E1623K	0.29
BLCA	chr12	49022769	Nonsense_Mutation	NA	Q5387*	0.59
BLCA	chr12	49051738	Nonsense_Mutation	novel	E649*	0.09
BLCA	chr12	49026185	Nonsense_Mutation	NA	Q5261*	0.37
BLCA	chr12	49028936	Nonsense_Mutation	novel	Y4758*	0.42
BLCA	chr12	49050730	Frame_Shift_Del	novel	*P949Lfs5**	0.45
BLCA	chr12	49050718	Nonsense_Mutation	novel	L957*	0.54
BLCA	chr12	49052992	Silent	novel	L345L	0.5
BLCA	chr12	49026905	Nonsense_Mutation	rs587783695	R5021*	0.14
BLCA	chr12	49052996	Missense_Mutation	novel	S344C	0.06
BLCA	chr12	49022144	Frame_Shift_Ins	novel	N5474*	0.39
BLCA	chr12	49034067	Frame_Shift_Del	novel	*S3572Rfs78**	0.15
BLCA	chr12	49050359	Nonsense_Mutation	NA	K1077*	0.16
BLCA	chr12	49026249	Silent	rs543419394	P5239P	0.57
BLCA	chr12	49031386	Frame_Shift_Ins	novel	*I4440Nfs47**	0.51
BLCA	chr12	49054619	Frame_Shift_Ins	novel	*G104Rfs4**	0.58
BLCA	chr12	49040632	Nonsense_Mutation	NA	Q2380*	0.32
BLCA	chr12	49039434	Splice_Site	novel	X2743_splice	0.22
BLCA	chr12	49039435	Missense_Mutation	novel	Q2743H	0.22
BLCA	chr12	49039611	Nonsense_Mutation	rs587783727	R2685*	0.23
BLCA	chr12	49050885	Splice_Site	rs727503988	X933_splice	0.41
BLCA	chr12	49050901	Nonsense_Mutation	NA	Q928*	0.16
BLCA	chr12	49028075	Missense_Mutation	novel	V4817M	0.23
BLCA	chr12	49026458	Nonsense_Mutation	NA	Q5170*	0.12
BLCA	chr12	49037187	Missense_Mutation	novel	C3390F	0.35
BLCA	chr12	49030685	Frame_Shift_Del	novel	C4583*	0.29
BLCA	chr12	49052113	Frame_Shift_Del	novel	*E524Kfs406**	0.25
BLCA	chr12	49051198	Missense_Mutation	novel	E829Q	0.2
BLCA	chr12	49040835	Missense_Mutation	NA	S2312L	0.27
BLCA	chr12	49024896	Missense_Mutation	novel	D5279N	0.3
BLCA	chr12	49032590	Missense_Mutation	novel	E4039K	0.39
BLCA	chr12	49031255	Nonsense_Mutation	rs587783690	R4484*	0.22
BLCA	chr12	49052026	Missense_Mutation	novel	P553A	0.13
BLCA	chr12	49044249	Frame_Shift_Del	novel	*G1713Afs21**	0.2
BLCA	chr12	49031341	Missense_Mutation	rs372839823	R4455H	0.25
BLCA	chr12	49030632	Frame_Shift_Ins	novel	*G4603Afs5**	0.5
BLCA	chr12	49030376	Nonsense_Mutation	NA	Q4635*	0.35
BLCA	chr12	49027207	Frame_Shift_Del	novel	*S4915Lfs11**	0.68
BLCA	chr12	49038257	Frame_Shift_Del	novel	*N3034Mfs37**	0.18
BLCA	chr12	49026878	Missense_Mutation	NA	R5030C	0.28
BLCA	chr12	49054665	Frame_Shift_Del	novel	*P88Hfs42**	0.5
BLCA	chr12	49038552	Nonsense_Mutation	NA	S2935*	0.05
BLCA	chr12	49039883	Frame_Shift_Del	novel	*P2619Mfs61**	0.64
BLCA	chr12	49030919	Missense_Mutation	novel	E4549K	0.21
BLCA	chr12	49039867	Nonsense_Mutation	rs794727549	R2635*	0.28
BLCA	chr12	49026266	Nonsense_Mutation	novel	E5234*	0.37
BLCA	chr12	49031695	Frame_Shift_Del	novel	*P4337Lfs47**	0.55
BLCA	chr12	49049146	Frame_Shift_Del	novel	*A1327Pfs3**	0.25
BLCA	chr12	49054922	Nonsense_Mutation	novel	Q52*	0.55
BLCA	chr12	49052940	Nonsense_Mutation	novel	E363*	0.2
BLCA	chr12	49026887	Nonsense_Mutation	rs797045659	R5027*	0.37
BLCA	chr12	49024636	Missense_Mutation	rs763696810	M5332V	0.44
BLCA	chr12	49026950	Nonsense_Mutation	novel	E5006*	0.18
BLCA	chr12	49042587	Silent	novel	L1947L	0.19
BLCA	chr12	49054674	Missense_Mutation	NA	F85S	0.2
BLCA	chr12	49043867	Splice_Site	novel	X1773_splice	0.38
BLCA	chr12	49046264	Nonsense_Mutation	novel	E1527*	0.38
BLCA	chr12	49041002	Frame_Shift_Del	novel	*L2255Cfs3**	0.37
BLCA	chr12	49032119	Nonsense_Mutation	novel	Q4196*	0.25
BLCA	chr12	49033655	Nonsense_Mutation	novel	Q3684*	0.23
BLCA	chr12	49026559	Frame_Shift_Ins	novel	*H5136Rfs12**	0.45
BLCA	chr12	49053259	Frame_Shift_Del	novel	*F301Sfs3**	0.48
BLCA	chr12	49054922	Nonsense_Mutation	novel	Q52*	0.23
BLCA	chr12	49050389	Missense_Mutation	novel	E1067K	0.44
BLCA	chr12	49026277	Missense_Mutation	NA	C5230F	0.42
BLCA	chr12	49031666	Nonsense_Mutation	NA	Q4347*	0.25
BLCA	chr12	49026381	Missense_Mutation	NA	Q5195H	0.44
BLCA	chr12	49026655	Missense_Mutation	NA	C5104Y	0.47
BLCA	chr12	49042646	Splice_Site	novel	X1928_splice	0.37
BLCA	chr12	49042879	Splice_Site	novel	X1882_splice	0.23
BLCA	chr12	49022104	Missense_Mutation	novel	T5487K	0.11
BLCA	chr12	49047983	Frame_Shift_Ins	novel	*Y1407Lfs25**	0.32
BLCA	chr12	49051883	Silent	novel	F600F	0.22
BLCA	chr12	49052710	Splice_Site	novel	X371_splice	0.25
BLCA	chr12	49037741	Silent	novel	G3205G	0.19
BLCA	chr12	49037742	Missense_Mutation	NA	G3205V	0.19
BLCA	chr12	49042158	Nonsense_Mutation	NA	Q2014*	0.5
BLCA	chr12	49032746	Frame_Shift_Ins	novel	*P3987Ifs36**	0.22
BLCA	chr12	49033807	Missense_Mutation	novel	G3633V	0.55
BLCA	chr12	49026430	Missense_Mutation	rs267607237	R5179H	0.4
BLCA	chr12	49029164	Silent	novel	G4716G	0.34
BLCA	chr12	49024687	Nonsense_Mutation	rs587783699	Q5315*	0.22
BLCA	chr12	49030674	Frame_Shift_Del	novel	*V4585Afs3**	0.29
BLCA	chr12	49039940	Frame_Shift_Del	novel	*G2606Afs80**	0.43
BLCA	chr12	49050521	Nonsense_Mutation	novel	Q1023*	0.3
BLCA	chr12	49052914	Splice_Site	novel	X371_splice	0.27
BLCA	chr12	49053487	Silent	NA	C276C	0.29
BLCA	chr12	49050394	Missense_Mutation	novel	S1065L	0.15
BLCA	chr12	49030958	Nonsense_Mutation	rs587783692	R4536*	0.23
BLCA	chr12	49040542	Nonsense_Mutation	NA	R2410*	0.55
BLCA	chr12	49027307	Missense_Mutation	novel	E4887Q	0.31
BLCA	chr12	49031855	Nonsense_Mutation	NA	Q4284*	0.52
BLCA	chr12	49034846	Nonsense_Mutation	novel	Q3441*	0.41
BLCA	chr12	49050889	Nonsense_Mutation	novel	*P932Sfs2**	0.41
BLCA	chr12	49028883	Missense_Mutation	novel	K4776R	0.05
BLCA	chr12	49022302	Missense_Mutation	novel	T5464P	0.25
BLCA	chr12	49026625	Missense_Mutation	novel	H5114R	0.48
BLCA	chr12	49040957	Silent	NA	P2271P	0.17
BLCA	chr12	49042620	Frame_Shift_Del	novel	*S1937Pfs110**	0.46
BLCA	chr12	49022073	In_Frame_Del	rs587783704	I5497del	0.73
BLCA	chr12	49031437	Frame_Shift_Del	novel	*P4423Hfs9**	0.34
BLCA	chr12	49040998	Frame_Shift_Del	novel	V2257*	0.38
BLCA	chr12	49033343	Nonsense_Mutation	NA	Q3788*	0.45
BLCA	chr12	49022308	Missense_Mutation	NA	D5462H	0.16
BLCA	chr12	49032017	Nonsense_Mutation	rs793888511	Q4230*	0.53
BLCA	chr12	49037813	Missense_Mutation	NA	E3181D	0.52
BLCA	chr12	49038340	Missense_Mutation	NA	D3006N	0.46
BLCA	chr12	49040995	Missense_Mutation	NA	E2259K	0.35
BLCA	chr12	49051481	Silent	NA	L734L	0.17
BLCA	chr12	49039611	Nonsense_Mutation	rs587783727	R2685*	0.16
BLCA	chr12	49040524	Nonsense_Mutation	NA	Q2416*	0.57
BLCA	chr12	49028874	Missense_Mutation	novel	G4779V	0.25
BLCA	chr12	49053642	Splice_Site	novel	X225_splice	0.31
BLCA	chr12	49046301	Nonsense_Mutation	NA	Y1514*	0.52
BLCA	chr12	49032322	Missense_Mutation	novel	S4128L	0.19
BLCA	chr12	49044253	Frame_Shift_Del	novel	*K1712Rfs10**	0.64
BLCA	chr12	49051366	Frame_Shift_Del	novel	*Q773Sfs157**	0.24
BLCA	chr12	49026420	Frame_Shift_Ins	NA	*L5183Pfs16**	0.23
BLCA	chr12	49022308	Missense_Mutation	NA	D5462H	0.17
BLCA	chr12	49027020	Nonsense_Mutation	novel	W4982*	0.33
BLCA	chr12	49027232	Missense_Mutation	novel	E4912K	0.37
BLCA	chr12	49031762	Nonsense_Mutation	novel	Q4315*	0.26
BLCA	chr12	49031295	Missense_Mutation	NA	K4470N	0.39
BLCA	chr12	49034123	Nonsense_Mutation	NA	E3562*	0.42
BLCA	chr12	49044812	Nonsense_Mutation	NA	S1632*	0.43
BLCA	chr12	49050901	Nonsense_Mutation	NA	Q928*	0.15
BLCA	chr12	49054656	Nonsense_Mutation	novel	W91*	0.44
BLCA	chr12	49033715	Frame_Shift_Del	novel	*M3662Ifs11**	0.22
BRCA	chr12	49051550	Silent	NA	P711P	0.31
BRCA	chr12	49042626	Silent	novel	N1934N	0.1
BRCA	chr12	49032991	Missense_Mutation	NA	Q3905L	0.13
BRCA	chr12	49041436	Frame_Shift_Del	NA	*A2112Hfs32**	0.47
BRCA	chr12	49053026	Missense_Mutation	NA	N334I	0.38
BRCA	chr12	49043414	Missense_Mutation	NA	D1828H	0.13
BRCA	chr12	49042568	Missense_Mutation	NA	D1954H	0.25
BRCA	chr12	49051763	In_Frame_Ins	novel	D632_E640dup	0.04
BRCA	chr12	49050986	Silent	NA	A899A	0.57
BRCA	chr12	49037651	Missense_Mutation	NA	K3235N	0.25
BRCA	chr12	49050975	Missense_Mutation	novel	P903L	0.07
BRCA	chr12	49033123	In_Frame_Del	novel	Q3861_Q3863del	0.68
BRCA	chr12	49033945	Missense_Mutation	NA	E3587V	0.58
BRCA	chr12	49046715	Missense_Mutation	NA	D1438N	0.38
BRCA	chr12	49052126	Frame_Shift_Del	NA	*L520Cfs410**	0.35
BRCA	chr12	49040889	Frame_Shift_Del	novel	*L2292Hfs28**	0.83
BRCA	chr12	49030733	Silent	NA	I4569I	0.12
BRCA	chr12	49034647	Missense_Mutation	novel	A3459S	0.1
BRCA	chr12	49034609	Missense_Mutation	novel	Q3471H	0.19
BRCA	chr12	49027833	Missense_Mutation	NA	S4871R	0.17
BRCA	chr12	49028946	Frame_Shift_Ins	novel	*T4755Nfs27**	0.09
BRCA	chr12	49033829	Missense_Mutation	rs766696812	R3626W	0.33
BRCA	chr12	49024634	Missense_Mutation	NA	M5332I	0.26
BRCA	chr12	49050527	Missense_Mutation	NA	P1021S	0.13
BRCA	chr12	49037692	Frame_Shift_Del	novel	*L3220Wfs9**	0.17
BRCA	chr12	49033837	In_Frame_Del	NA	Q3623del	0.31
BRCA	chr12	49041006	Nonsense_Mutation	novel	L2255*	0.5
BRCA	chr12	49042191	Missense_Mutation	novel	L2003V	0.07
BRCA	chr12	49046370	Nonsense_Mutation	novel	W1491*	0.45
BRCA	chr12	49031295	Missense_Mutation	NA	K4470N	0.3
BRCA	chr12	49030949	Frame_Shift_Ins	novel	*L4539Ffs15**	0.49
BRCA	chr12	49033411	Missense_Mutation	NA	T3765R	0.19
BRCA	chr12	49021615	3'UTR	novel		1
BRCA	chr12	49033174	Missense_Mutation	NA	G3844V	0.14
BRCA	chr12	49034636	Silent	NA	L3462L	0.33
BRCA	chr12	49043695	Frame_Shift_Ins	novel	*T1803Yfs23**	0.1
BRCA	chr12	49033961	Missense_Mutation	NA	R3582W	0.55
BRCA	chr12	49043178	Missense_Mutation	NA	D1848N	0.24
BRCA	chr12	49034167	Missense_Mutation	rs775632051	R3547H	0.46
BRCA	chr12	49051376	Silent	NA	H769H	0.14
BRCA	chr12	49053990	Frame_Shift_Del	NA	*A221Lfs40**	0.15
BRCA	chr12	49044444	Missense_Mutation	novel	T1681N	0.21
BRCA	chr12	49031629	Missense_Mutation	novel	S4359L	0.1
CESC	chr12	49020342	3'UTR	novel		0.37
CESC	chr12	49040177	Frame_Shift_Del	NA	*S2532Lfs11**	0.12
CESC	chr12	49026836	Missense_Mutation	NA	D5044N	0.41
CESC	chr12	49027049	Missense_Mutation	NA	D4973H	0.38
CESC	chr12	49030768	Missense_Mutation	NA	E4558Q	0.28
CESC	chr12	49031276	Missense_Mutation	NA	G4477R	0.26
CESC	chr12	49026224	Nonsense_Mutation	NA	Q5248*	0.47
CESC	chr12	49022769	Nonsense_Mutation	NA	Q5387*	0.15
CESC	chr12	49046724	Nonsense_Mutation	novel	Q1435*	0.44
CESC	chr12	49045940	Missense_Mutation	NA	P1574L	0.15
CESC	chr12	49031855	Nonsense_Mutation	NA	Q4284*	0.15
CESC	chr12	49040578	Missense_Mutation	rs200238459	L2398V	0.08
CESC	chr12	49019904	3'UTR	novel		0.21
CESC	chr12	49053291	Silent	NA	V290V	0.41
CESC	chr12	49037394	Missense_Mutation	rs753081311	R3321Q	0.5
CESC	chr12	49026421	Frame_Shift_Del	NA	*G5182Afs61**	0.5
CESC	chr12	49032726	Silent	novel	Q3993Q	0.11
CESC	chr12	49038059	Silent	rs368160122	R3099R	0.4
CESC	chr12	49032991	Missense_Mutation	NA	Q3905L	0.09
CESC	chr12	49037612	Silent	NA	L3248L	0.32
CESC	chr12	49047997	Nonsense_Mutation	NA	Q1402*	0.36
CESC	chr12	49026626	Missense_Mutation	NA	H5114Y	0.38
CESC	chr12	49040835	Nonsense_Mutation	NA	S2312*	0.36
CESC	chr12	49041687	Missense_Mutation	NA	R2068W	0.22
CESC	chr12	49044828	Missense_Mutation	NA	E1627K	0.3
CESC	chr12	49046367	Silent	NA	Q1492Q	0.18
CESC	chr12	49048727	Missense_Mutation	NA	E1355K	0.2
CESC	chr12	49048757	Missense_Mutation	NA	D1345H	0.37
CESC	chr12	49048763	Missense_Mutation	NA	D1343N	0.16
CESC	chr12	49034241	Silent	NA	Q3522Q	0.33
CESC	chr12	49044257	Nonsense_Mutation	rs794727342	K1711*	0.32
CESC	chr12	49040844	Nonsense_Mutation	NA	S2309*	0.42
CESC	chr12	49032686	Nonsense_Mutation	NA	Q4007*	0.79
CESC	chr12	49020717	3'UTR	novel		0.14
CESC	chr12	49039728	Missense_Mutation	rs779506886	R2681Q	0.11
CESC	chr12	49032299	Frame_Shift_Del	novel	*Q4136Afs31**	0.08
CESC	chr12	49034846	Nonsense_Mutation	novel	Q3441*	0.57
CESC	chr12	49051048	Nonsense_Mutation	novel	E879*	0.36
CESC	chr12	49026709	Missense_Mutation	rs775506569	R5086Q	0.31
CESC	chr12	49040613	Missense_Mutation	rs763262491	R2386Q	0.24
CESC	chr12	49051576	Missense_Mutation	novel	E703K	0.41
CESC	chr12	49039307	Silent	NA	L2761L	0.7
CESC	chr12	49027061	Nonsense_Mutation	NA	E4969*	0.13
CESC	chr12	49040473	Nonsense_Mutation	NA	E2433*	0.15
CESC	chr12	49043740	Missense_Mutation	rs755651886	A1788T	0.18
CESC	chr12	49021177	3'UTR	novel		0.16
CESC	chr12	49031861	Nonsense_Mutation	NA	R4282*	0.54
CESC	chr12	49040632	Nonsense_Mutation	NA	Q2380*	0.38
CESC	chr12	49038094	Missense_Mutation	novel	G3088W	0.09
CESC	chr12	49020006	3'UTR	novel		0.34
CESC	chr12	49021797	Missense_Mutation	novel	R5533W	0.39
CESC	chr12	49026280	Missense_Mutation	rs201628357	R5229H	0.38
CESC	chr12	49027256	Nonsense_Mutation	rs398123721	R4904*	0.37
CESC	chr12	49050905	Silent	NA	S926S	0.39
CESC	chr12	49040220	Frame_Shift_Del	novel	*S2512Ifs26**	0.15
CESC	chr12	49033328	Nonsense_Mutation	NA	Q3793*	0.67
CESC	chr12	49040797	Missense_Mutation	NA	D2325N	0.32
CESC	chr12	49037176	Nonsense_Mutation	NA	Q3394*	0.13
CESC	chr12	49019503	3'UTR	novel		0.27
CESC	chr12	49055008	Missense_Mutation	novel	S23F	0.26
CESC	chr12	49047997	Nonsense_Mutation	NA	Q1402*	0.35
CESC	chr12	49040770	Missense_Mutation	novel	R2334W	0.21
CESC	chr12	49032517	Missense_Mutation	novel	G4063E	0.14
CESC	chr12	49050503	Nonsense_Mutation	NA	Q1029*	0.5
CESC	chr12	49044299	Missense_Mutation	novel	G1697C	0.31
CESC	chr12	49028142	Splice_Site	NA	X4795_splice	0.37
CESC	chr12	49033812	Silent	NA	L3631L	0.25
CESC	chr12	49034069	Nonsense_Mutation	NA	Q3580*	0.34
CESC	chr12	49024637	Silent	novel	L5331L	0.36
CESC	chr12	49024882	Silent	novel	L5283L	0.43
CESC	chr12	49026899	Missense_Mutation	novel	D5023N	0.3
CESC	chr12	49032990	Silent	NA	Q3905Q	0.42
CESC	chr12	49024896	Missense_Mutation	NA	D5279Y	0.41
CESC	chr12	49038246	Frame_Shift_Ins	novel	*H3037Pfs4**	0.5
CESC	chr12	49041012	Frame_Shift_Del	novel	*K2246Ifs11**	0.65
CESC	chr12	49019656	3'UTR	novel		0.12
CESC	chr12	49048739	Nonsense_Mutation	novel	E1351*	0.26
CESC	chr12	49042560	Splice_Site	NA	X1956_splice	0.15
CESC	chr12	49037177	Silent	rs368612015	P3393P	0.44
CESC	chr12	49026690	Nonsense_Mutation	novel	C5092*	0.16
CESC	chr12	49054351	Missense_Mutation	novel	E156K	0.29
CESC	chr12	49054564	Nonsense_Mutation	novel	E122*	0.29
CHOL	chr12	49054311	Nonsense_Mutation	novel	S169*	0.14
CHOL	chr12	49024860	Missense_Mutation	NA	E5291K	0.11
CHOL	chr12	49032784	In_Frame_Del	novel	Q3953_Q3974del	0.32
CHOL	chr12	49032842	In_Frame_Del	novel	Q3938_Q3954del	0.25
COAD	chr12	49038842	Silent	NA	P2838P	0.28
COAD	chr12	49040709	Frame_Shift_Del	NA	*P2354Lfs30**	0.12
COAD	chr12	49041416	Frame_Shift_Del	NA	*A2119Lfs25**	0.13
COAD	chr12	49049188	Missense_Mutation	rs769189340	R1313W	0.27
COAD	chr12	49048762	Missense_Mutation	NA	D1343G	0.4
COAD	chr12	49051743	Frame_Shift_Del	NA	*P647Hfs283**	0.23
COAD	chr12	49024578	Missense_Mutation	NA	R5351L	0.25
COAD	chr12	49032500	Missense_Mutation	NA	L4069V	0.23
COAD	chr12	49033097	Missense_Mutation	NA	M3870V	0.18
COAD	chr12	49044426	Missense_Mutation	NA	R1687H	0.11
COAD	chr12	49042745	Silent	NA	L1926L	0.34
COAD	chr12	49033896	Silent	NA	Q3603Q	0.06
COAD	chr12	49033884	Silent	NA	Q3607Q	0.33
COAD	chr12	49049814	Silent	NA	R1258R	0.18
COAD	chr12	49029214	Missense_Mutation	rs369583907	D4700N	0.25
COAD	chr12	49037178	Missense_Mutation	rs754209328	P3393L	0.26
COAD	chr12	49040709	Frame_Shift_Del	NA	*P2354Lfs30**	0.22
COAD	chr12	49046369	Nonsense_Mutation	NA	Q1492*	0.56
COAD	chr12	49037400	Missense_Mutation	rs751075517	G3319D	0.31
COAD	chr12	49024703	Silent	NA	P5309P	0.5
COAD	chr12	49032848	Nonsense_Mutation	novel	Q3953*	0.26
COAD	chr12	49040709	Frame_Shift_Del	NA	*P2354Lfs30**	0.16
COAD	chr12	49040709	Frame_Shift_Del	NA	*P2354Lfs30**	0.29
COAD	chr12	49038441	Missense_Mutation	NA	E2972G	0.2
COAD	chr12	49031447	Missense_Mutation	rs199797812	R4420W	0.5
COAD	chr12	49043774	Missense_Mutation	NA	F1776L	0.2
COAD	chr12	49031492	Nonsense_Mutation	novel	Q4405*	0.08
COAD	chr12	49033483	In_Frame_Del	rs765688554	Q3744_Q3745del	0.46
COAD	chr12	49024941	Missense_Mutation	NA	W5264R	0.05
COAD	chr12	49040709	Frame_Shift_Del	NA	*P2354Lfs30**	0.07
COAD	chr12	49030394	Frame_Shift_Ins	NA	*T4629Hfs18**	0.31
COAD	chr12	49039519	Frame_Shift_Del	novel	*P2716Lfs17**	0.24
COAD	chr12	49031830	Missense_Mutation	NA	P4292L	0.14
COAD	chr12	49031962	Missense_Mutation	NA	T4248I	0.49
COAD	chr12	49052261	Silent	novel	L474L	0.07
COAD	chr12	49044867	Missense_Mutation	rs375118713	R1614W	0.24
COAD	chr12	49050981	Missense_Mutation	novel	S901Y	0.26
COAD	chr12	49043758	Silent	NA	L1782L	0.11
COAD	chr12	49050595	Frame_Shift_Del	NA	*P998Lfs2**	0.39
COAD	chr12	49038990	Splice_Site	NA	X2789_splice	0.4
COAD	chr12	49049884	Frame_Shift_Del	NA	*G1235Vfs95**	0.43
COAD	chr12	49026421	Missense_Mutation	NA	G5182D	0.12
COAD	chr12	49050594	Frame_Shift_Ins	novel	*M999Yfs69**	0.2
COAD	chr12	49052054	Silent	novel	S543S	0.34
COAD	chr12	49053623	Missense_Mutation	novel	V231G	0.2
COAD	chr12	49022633	Missense_Mutation	rs398123734	R5432Q	0.25
COAD	chr12	49038147	Missense_Mutation	NA	L3070P	0.13
COAD	chr12	49046139	Missense_Mutation	NA	E1540G	0.44
COAD	chr12	49026421	Frame_Shift_Del	NA	*G5182Afs61**	0.57
COAD	chr12	49040935	Frame_Shift_Ins	NA	*G2279Wfs20**	0.45
COAD	chr12	49042610	Missense_Mutation	NA	P1940T	0.43
COAD	chr12	49040709	Frame_Shift_Del	NA	*P2354Lfs30**	0.22
COAD	chr12	49033484	Nonsense_Mutation	novel	Q3741*	0.31
COAD	chr12	49041131	Silent	rs200895959	G2213G	0.25
COAD	chr12	49054097	Missense_Mutation	rs771025627	R185H	0.34
COAD	chr12	49046347	Missense_Mutation	NA	G1499V	0.14
COAD	chr12	49034900	Missense_Mutation	NA	P3423T	0.45
COAD	chr12	49038637	Frame_Shift_Del	NA	*Y2907Tfs3**	0.26
COAD	chr12	49046157	Missense_Mutation	NA	C1534Y	0.6
COAD	chr12	49046258	Splice_Site	NA	X1528_splice	0.15
COAD	chr12	49050154	Missense_Mutation	NA	A1145D	0.35
COAD	chr12	49053990	Frame_Shift_Del	NA	*A221Lfs40**	0.08
COAD	chr12	49027088	Nonsense_Mutation	NA	R4960*	0.13
COAD	chr12	49046150	Silent	rs751508761	S1536S	0.23
COAD	chr12	49051149	Frame_Shift_Ins	rs767415197	*R845Pfs3**	0.16
COAD	chr12	49041191	Silent	rs556666267	P2193P	0.42
COAD	chr12	49054983	Silent	novel	S31S	0.3
COAD	chr12	49030395	Frame_Shift_Del	NA	*T4629Pfs11**	0.27
COAD	chr12	49046632	Frame_Shift_Del	NA	*K1466Rfs40**	0.31
COAD	chr12	49032239	Frame_Shift_Del	novel	*Q4156Nfs5**	0.15
COAD	chr12	49042188	Nonsense_Mutation	NA	Q2004*	0.39
COAD	chr12	49024916	Missense_Mutation	NA	A5272V	0.11
COAD	chr12	49050603	Silent	NA	P995P	0.12
COAD	chr12	49033123	In_Frame_Del	rs777796038	Q3863del	0.33
COAD	chr12	49051890	Missense_Mutation	rs377761041	R598H	0.27
COAD	chr12	49031727	Frame_Shift_Del	NA	*S4327Afs57**	0.44
COAD	chr12	49039481	Missense_Mutation	novel	A2728V	0.18
COAD	chr12	49040295	Missense_Mutation	NA	G2492V	0.17
COAD	chr12	49026543	Silent	NA	P5141P	0.36
COAD	chr12	49031254	Missense_Mutation	NA	R4484Q	0.41
COAD	chr12	49043871	Silent	NA	L1772L	0.29
COAD	chr12	49031766	Silent	NA	S4313S	0.1
COAD	chr12	49033896	Silent	NA	Q3603Q	0.08
COAD	chr12	49040709	Frame_Shift_Del	NA	*P2354Lfs30**	0.12
COAD	chr12	49034153	Frame_Shift_Ins	rs763440821	*A3552Sfs4**	0.51
COAD	chr12	49038051	Frame_Shift_Del	NA	*P3102Lfs17**	0.26
COAD	chr12	49038488	Silent	rs758061875	T2956T	0.26
COAD	chr12	49039817	Silent	NA	G2651G	0.25
COAD	chr12	49052090	Silent	NA	A531A	0.42
COAD	chr12	49038091	Frame_Shift_Del	NA	*V3089Wfs30**	0.12
COAD	chr12	49052286	Missense_Mutation	NA	R466H	0.38
COAD	chr12	49051026	Frame_Shift_Del	NA	*P886Lfs44**	0.57
COAD	chr12	49051743	Frame_Shift_Del	NA	*P647Hfs283**	0.24
COAD	chr12	49022331	Missense_Mutation	NA	R5454Q	0.21
COAD	chr12	49027102	Missense_Mutation	NA	S4955F	0.28
COAD	chr12	49052620	Missense_Mutation	novel	V401A	0.06
COAD	chr12	49022101	Missense_Mutation	novel	F5488S	0.16
COAD	chr12	49031290	Missense_Mutation	rs768387349	V4472A	0.18
COAD	chr12	49044500	Silent	rs143063879	C1662C	0.09
COAD	chr12	49024861	Silent	rs776989239	G5290G	0.32
COAD	chr12	49037566	Missense_Mutation	NA	Q3264K	0.17
COAD	chr12	49038127	Missense_Mutation	NA	N3077D	0.28
COAD	chr12	49044259	Missense_Mutation	rs587778457	T1710M	0.16
COAD	chr12	49021850	Missense_Mutation	NA	D5515G	0.27
COAD	chr12	49032825	Silent	novel	Q3960Q	0.08
COAD	chr12	49040307	Missense_Mutation	rs779629382	S2488L	0.23
COAD	chr12	49022700	Missense_Mutation	novel	G5410W	0.34
COAD	chr12	49026740	Frame_Shift_Del	novel	*A5076Hfs2**	0.12
COAD	chr12	49033896	Silent	NA	Q3603Q	0.16
COAD	chr12	49040177	Frame_Shift_Del	NA	*S2532Lfs11**	0.24
COAD	chr12	49033884	Silent	NA	Q3607Q	0.25
COAD	chr12	49038732	Missense_Mutation	NA	A2875V	0.32
COAD	chr12	49044766	Silent	rs748740454	T1647T	0.13
COAD	chr12	49049884	Frame_Shift_Del	NA	*G1235Vfs95**	0.1
COAD	chr12	49032760	Missense_Mutation	rs760983900	R3982Q	0.24
COAD	chr12	49042574	Missense_Mutation	NA	F1952L	0.15
COAD	chr12	49030356	Silent	rs753898265	G4641G	0.29
COAD	chr12	49052114	Silent	rs568575580	P523P	0.36
COAD	chr12	49046298	In_Frame_Del	novel	H1511_V1515del	0.07
COAD	chr12	49040438	Silent	NA	F2444F	0.68
COAD	chr12	49033762	Missense_Mutation	rs758858726	P3648L	0.18
COAD	chr12	49040837	Silent	NA	S2311S	0.6
COAD	chr12	49037654	Silent	NA	D3234D	0.27
COAD	chr12	49039939	Missense_Mutation	rs572359740	R2611C	0.07
COAD	chr12	49044864	Nonsense_Mutation	NA	R1615*	0.52
DLBC	chr12	49022137	Missense_Mutation	novel	S5476Y	0.33
DLBC	chr12	49022139	Missense_Mutation	novel	H5475Q	0.35
DLBC	chr12	49048032	Frame_Shift_Ins	rs756471180	*A1390Gfs42**	0.42
DLBC	chr12	49041250	Nonsense_Mutation	NA	Q2174*	0.36
DLBC	chr12	49027906	Missense_Mutation	novel	G4847V	0.36
DLBC	chr12	49033896	Silent	NA	Q3603Q	0.07
DLBC	chr12	49033541	Nonsense_Mutation	novel	Q3722*	0.68
DLBC	chr12	49042158	Nonsense_Mutation	NA	Q2014*	0.24
DLBC	chr12	49042593	Frame_Shift_Ins	novel	*G1946Rfs11**	0.2
DLBC	chr12	49026641	Missense_Mutation	novel	C5109R	0.26
DLBC	chr12	49034409	Splice_Site	novel	X3503_splice	0.61
DLBC	chr12	49032602	Frame_Shift_Del	novel	*S4034Qfs15**	0.63
DLBC	chr12	49051263	Frame_Shift_Ins	novel	*S807Ffs5**	0.69
DLBC	chr12	49051265	Silent	novel	L806L	0.7
DLBC	chr12	49038664	Nonsense_Mutation	novel	Q2898*	0.28
DLBC	chr12	49033319	Nonsense_Mutation	NA	Q3796*	0.17
ESCA	chr12	49033481	Nonsense_Mutation	novel	Q3742*	0.17
ESCA	chr12	49026430	Missense_Mutation	rs267607237	R5179H	0.31
ESCA	chr12	49026594	Frame_Shift_Ins	novel	*M5124Ifs14**	0.12
ESCA	chr12	49033133	Nonsense_Mutation	novel	Q3858*	0.5
ESCA	chr12	49031273	Missense_Mutation	rs562043836	R4478W	0.17
ESCA	chr12	49038067	Missense_Mutation	novel	E3097K	0.05
ESCA	chr12	49034135	Nonsense_Mutation	novel	E3558*	0.22
ESCA	chr12	49049684	Frame_Shift_Del	novel	*K1301Gfs22**	0.38
ESCA	chr12	49037474	Frame_Shift_Del	novel	*P3291Hfs6**	0.43
ESCA	chr12	49037862	Frame_Shift_Ins	novel	*D3165Gfs11**	0.47
ESCA	chr12	49031720	Nonsense_Mutation	novel	Q4329*	0.25
ESCA	chr12	49034894	Frame_Shift_Ins	novel	*A3425Cfs43**	0.32
ESCA	chr12	49041917	Splice_Region	novel	L2061L	0.44
ESCA	chr12	49026640	Missense_Mutation	NA	C5109F	0.42
ESCA	chr12	49048071	Splice_Site	novel	X1378_splice	0.44
ESCA	chr12	49029118	Nonsense_Mutation	novel	Q4732*	0.19
ESCA	chr12	49029119	Missense_Mutation	novel	E4731D	0.19
ESCA	chr12	49037437	Missense_Mutation	novel	A3307T	0.32
ESCA	chr12	49051890	Missense_Mutation	rs377761041	R598H	0.12
ESCA	chr12	49039735	Nonsense_Mutation	novel	K2679*	0.15
ESCA	chr12	49022769	Nonsense_Mutation	NA	Q5387*	0.31
ESCA	chr12	49052923	Silent	novel	V368V	0.18
ESCA	chr12	49038626	Frame_Shift_Del	NA	*S2910Rfs32**	0.26
ESCA	chr12	49051367	Silent	novel	P772P	0.55
ESCA	chr12	49039761	Missense_Mutation	novel	S2670F	0.36
ESCA	chr12	49042193	Missense_Mutation	novel	S2002I	0.53
ESCA	chr12	49038247	Frame_Shift_Del	novel	*H3037Tfs34**	0.36
ESCA	chr12	49032800	Nonsense_Mutation	NA	Q3969*	0.31
ESCA	chr12	49039497	Missense_Mutation	novel	E2723K	0.37
ESCA	chr12	49050790	Frame_Shift_Del	novel	*D933Vfs25**	0.23
GBM	chr12	49049869	Frame_Shift_Ins	novel	*M1240Tfs11**	0.34
GBM	chr12	49054080	Missense_Mutation	NA	R191W	0.3
GBM	chr12	49041498	Missense_Mutation	novel	G2091A	0.05
GBM	chr12	49054539	Missense_Mutation	NA	G130E	0.54
GBM	chr12	49028883	Missense_Mutation	novel	K4776T	0.07
GBM	chr12	49038648	Missense_Mutation	novel	R2903I	0.28
GBM	chr12	49040415	Missense_Mutation	novel	R2452H	0.46
GBM	chr12	49040948	Silent	novel	S2274S	0.1
GBM	chr12	49049913	Silent	novel	P1225P	0.27
GBM	chr12	49026974	Missense_Mutation	novel	K4998E	0.11
GBM	chr12	49038433	Missense_Mutation	rs544530436	R2975C	0.39
GBM	chr12	49026756	Nonsense_Mutation	NA	Y5070*	0.32
GBM	chr12	49046415	Silent	novel	S1476S	0.14
GBM	chr12	49034595	Missense_Mutation	novel	A3476G	0.08
GBM	chr12	49038443	Silent	novel	T2971T	0.35
GBM	chr12	49042740	Splice_Site	rs766123066	X1928_splice	0.17
HNSC	chr12	49042819	Nonsense_Mutation	novel	E1902*	0.48
HNSC	chr12	49054752	Splice_Site	NA	X59_splice	0.6
HNSC	chr12	49040220	Frame_Shift_Del	novel	*S2512Ifs26**	0.55
HNSC	chr12	49033586	Nonsense_Mutation	NA	R3707*	0.09
HNSC	chr12	49040152	Nonsense_Mutation	novel	Q2540*	0.38
HNSC	chr12	49051401	Frame_Shift_Del	novel	*L761Hfs169**	0.17
HNSC	chr12	49053602	Frame_Shift_Del	novel	*L238Cfs23**	0.69
HNSC	chr12	49046631	Frame_Shift_Ins	NA	*K1466Qfs25**	0.1
HNSC	chr12	49029417	Nonsense_Mutation	novel	Q4687*	0.5
HNSC	chr12	49054337	Silent	novel	V160V	0.37
HNSC	chr12	49038091	Frame_Shift_Del	NA	*V3089Wfs30**	0.48
HNSC	chr12	49021841	Missense_Mutation	novel	D5518G	0.19
HNSC	chr12	49031255	Nonsense_Mutation	rs587783690	R4484*	0.43
HNSC	chr12	49038440	Silent	novel	E2972E	0.23
HNSC	chr12	49046647	Frame_Shift_Ins	novel	*L1461Tfs30**	0.19
HNSC	chr12	49040524	Nonsense_Mutation	NA	Q2416*	0.11
HNSC	chr12	49037891	Frame_Shift_Ins	novel	*P3156Afs20**	0.6
HNSC	chr12	49044402	Splice_Site	novel	X1695_splice	0.35
HNSC	chr12	49049920	Nonsense_Mutation	novel	S1223*	0.39
HNSC	chr12	49044812	Nonsense_Mutation	NA	S1632*	0.2
HNSC	chr12	49054910	Nonsense_Mutation	novel	Q56*	0.21
HNSC	chr12	49026781	Missense_Mutation	novel	C5062F	0.18
HNSC	chr12	49051723	Frame_Shift_Del	novel	*S654Pfs276**	0.42
HNSC	chr12	49024702	Missense_Mutation	novel	G5310R	0.44
HNSC	chr12	49048709	Nonsense_Mutation	NA	Q1361*	0.42
HNSC	chr12	49040761	Nonsense_Mutation	novel	Q2337*	0.3
HNSC	chr12	49051343	Nonsense_Mutation	novel	C780*	0.41
HNSC	chr12	49022633	Missense_Mutation	rs398123734	R5432Q	0.26
HNSC	chr12	49046375	Nonsense_Mutation	novel	E1490*	0.17
HNSC	chr12	49026401	Missense_Mutation	NA	G5189R	0.19
HNSC	chr12	49042200	Nonsense_Mutation	NA	Q2000*	0.53
HNSC	chr12	49022838	Missense_Mutation	novel	Y5364N	0.47
HNSC	chr12	49026889	Missense_Mutation	NA	P5026L	0.41
HNSC	chr12	49039294	Missense_Mutation	novel	S2765F	0.38
HNSC	chr12	49026325	Missense_Mutation	rs398123729	R5214H	0.42
HNSC	chr12	49026626	Missense_Mutation	NA	H5114Y	0.28
HNSC	chr12	49051542	Missense_Mutation	rs747636808	S714L	0.16
HNSC	chr12	49026764	Frame_Shift_Del	novel	*C5062Rfs10**	0.18
HNSC	chr12	49040993	Missense_Mutation	novel	E2259D	0.06
HNSC	chr12	49022063	Nonsense_Mutation	NA	R5501*	0.26
HNSC	chr12	49034667	Splice_Site	novel	X3452_splice	0.21
HNSC	chr12	49044481	Missense_Mutation	NA	P1669S	0.18
HNSC	chr12	49033475	Nonsense_Mutation	novel	Q3744*	0.22
HNSC	chr12	49026266	Missense_Mutation	novel	E5234K	0.27
HNSC	chr12	49026888	Frame_Shift_Ins	novel	*R5027Tfs12**	0.2
HNSC	chr12	49050190	Nonsense_Mutation	novel	S1133*	0.29
HNSC	chr12	49034581	Splice_Site	rs749356633	X3480_splice	0.33
HNSC	chr12	49050924	Missense_Mutation	novel	S920C	0.38
HNSC	chr12	49053596	Missense_Mutation	novel	D240G	0.43
HNSC	chr12	49041117	Frame_Shift_Del	novel	*P2218Lfs46**	0.22
HNSC	chr12	49049834	Nonsense_Mutation	rs727503987	R1252*	0.27
HNSC	chr12	49026845	Missense_Mutation	novel	G5041R	0.26
HNSC	chr12	49028913	Missense_Mutation	novel	P4766L	0.36
HNSC	chr12	49031932	Frame_Shift_Del	novel	*G4255Lfs75**	0.17
HNSC	chr12	49038661	Missense_Mutation	rs587778472	G2899S	0.37
HNSC	chr12	49054013	Missense_Mutation	novel	L213P	0.18
HNSC	chr12	49039605	Nonsense_Mutation	NA	R2687*	0.34
HNSC	chr12	49049834	Nonsense_Mutation	rs727503987	R1252*	0.21
HNSC	chr12	49044242	Missense_Mutation	novel	A1716S	0.28
HNSC	chr12	49053531	Missense_Mutation	NA	A262T	0.29
HNSC	chr12	49052916	Missense_Mutation	NA	R371G	0.25
HNSC	chr12	49048030	Missense_Mutation	novel	E1391K	0.38
HNSC	chr12	49034436	Missense_Mutation	rs746854405	P3494L	0.29
HNSC	chr12	49041992	Splice_Site	novel	X2037_splice	0.84
HNSC	chr12	49044762	Nonsense_Mutation	NA	E1649*	0.25
HNSC	chr12	49050486	Frame_Shift_Del	novel	*L1032Pfs33**	0.25
HNSC	chr12	49039497	Nonsense_Mutation	novel	E2723*	0.11
HNSC	chr12	49040632	Nonsense_Mutation	NA	Q2380*	0.18
HNSC	chr12	49050484	Frame_Shift_Ins	novel	*Q1035Pfs33**	0.37
HNSC	chr12	49030322	Nonsense_Mutation	novel	K4653*	0.33
HNSC	chr12	49053302	Frame_Shift_Ins	novel	*K287Vfs18**	0.37
HNSC	chr12	49039450	Frame_Shift_Del	novel	*F2739Lfs18**	0.26
HNSC	chr12	49051843	Nonsense_Mutation	novel	E614*	0.17
HNSC	chr12	49042637	Missense_Mutation	novel	P1931T	0.35
HNSC	chr12	49037880	Frame_Shift_Del	novel	*Q3158Pfs2**	0.25
HNSC	chr12	49051723	Frame_Shift_Del	novel	*E649Pfs276**	0.23
HNSC	chr12	49044864	Nonsense_Mutation	NA	R1615*	0.22
HNSC	chr12	49042181	Nonsense_Mutation	novel	W2006*	0.79
HNSC	chr12	49040542	Nonsense_Mutation	NA	R2410*	0.18
HNSC	chr12	49040926	Frame_Shift_Del	novel	*R2282Gfs4**	0.15
HNSC	chr12	49049857	Frame_Shift_Ins	novel	*V1244Gfs6**	0.24
HNSC	chr12	49040322	Missense_Mutation	novel	S2483C	0.09
HNSC	chr12	49040117	Frame_Shift_Del	novel	*K2548Tfs103**	0.15
HNSC	chr12	49044966	Splice_Site	novel	X1581_splice	0.08
HNSC	chr12	49026491	Missense_Mutation	novel	R5159W	0.34
HNSC	chr12	49050197	Missense_Mutation	novel	P1131A	0.4
HNSC	chr12	49042560	Splice_Site	novel	X1956_splice	0.46
HNSC	chr12	49053239	Nonsense_Mutation	novel	E308*	0.23
HNSC	chr12	49038091	Frame_Shift_Del	NA	*V3089Wfs30**	0.53
HNSC	chr12	49050116	Nonsense_Mutation	NA	E1158*	0.37
HNSC	chr12	49038199	Frame_Shift_Ins	novel	*T3053Yfs2**	0.34
KICH	chr12	49038466	Missense_Mutation	novel	V2964F	0.28
KICH	chr12	49042607	Missense_Mutation	rs372271746	M1941V	0.44
KIRC	chr12	49053529	Silent	rs368315432	A262A	0.2
KIRC	chr12	49053530	Missense_Mutation	NA	A262D	0.2
KIRC	chr12	49049964	Silent	rs755572302	I1208I	0.24
KIRC	chr12	49049168	Missense_Mutation	novel	H1319Q	0.21
KIRC	chr12	49027089	Silent	NA	A4959A	0.16
KIRC	chr12	49031256	Silent	rs376096667	L4483L	0.38
KIRC	chr12	49046676	Missense_Mutation	NA	S1451C	0.27
KIRC	chr12	49049833	Missense_Mutation	rs753048826	R1252L	0.18
KIRC	chr12	49033381	Missense_Mutation	NA	G3775D	0.33
KIRC	chr12	49042804	Missense_Mutation	NA	L1907V	0.22
KIRC	chr12	49050555	Silent	rs373881433	P1011P	0.21
KIRC	chr12	49028942	Missense_Mutation	NA	K4756N	0.42
KIRC	chr12	49038320	In_Frame_Ins	novel	A3010_L3012dup	0.24
KIRP	chr12	49040427	Frame_Shift_Del	novel	*D2448Afs37**	0.39
KIRP	chr12	49043896	Missense_Mutation	NA	L1764P	0.32
KIRP	chr12	49034205	Silent	novel	V3534V	0.42
KIRP	chr12	49039597	Silent	NA	L2689L	0.33
KIRP	chr12	49044239	Missense_Mutation	novel	Q1717K	0.43
KIRP	chr12	49041415	Frame_Shift_Ins	rs755159728	*A2119Rfs36**	0.53
KIRP	chr12	49052292	Missense_Mutation	NA	A464V	0.25
KIRP	chr12	49038205	Missense_Mutation	NA	A3051P	0.23
KIRP	chr12	49032056	Nonsense_Mutation	novel	Q4217*	0.39
KIRP	chr12	49038378	Missense_Mutation	NA	L2993R	0.29
KIRP	chr12	49051847	Silent	novel	P612P	0.3
KIRP	chr12	49049774	Frame_Shift_Del	novel	*L1272Vfs13**	0.16
KIRP	chr12	49040614	Missense_Mutation	novel	R2386G	0.36
KIRP	chr12	49038047	Silent	NA	A3103A	0.38
KIRP	chr12	49040452	Missense_Mutation	rs375114492	V2440I	0.33
KIRP	chr12	49022351	Missense_Mutation	NA	N5447K	0.56
KIRP	chr12	49043162	Missense_Mutation	NA	A1853V	0.08
LAML	chr12	49022063	Nonsense_Mutation	NA	R5501*	0.03
LAML	chr12	49031584	Missense_Mutation	NA	L4374Q	0.63
LAML	chr12	49040020	Missense_Mutation	novel	T2584P	0.36
LAML	chr12	49030303	Missense_Mutation	novel	R4659Q	0.63
LGG	chr12	49026938	Missense_Mutation	novel	A5010T	0.33
LGG	chr12	49024928	Missense_Mutation	NA	I5268T	0.64
LGG	chr12	49048065	Frame_Shift_Del	rs398123744	*M1379Vfs52**	0.14
LGG	chr12	49022350	Nonsense_Mutation	NA	R5448*	0.45
LGG	chr12	49029133	Missense_Mutation	NA	S4727P	0.19
LGG	chr12	49051419	Missense_Mutation	rs776110112	R755Q	0.35
LGG	chr12	49052138	Silent	NA	L515L	0.36
LGG	chr12	49031287	Missense_Mutation	NA	Q4473P	0.2
LGG	chr12	49037430	Missense_Mutation	NA	S3309F	0.67
LGG	chr12	49043915	Missense_Mutation	novel	G1758R	0.45
LGG	chr12	49050412	Missense_Mutation	novel	G1059E	0.33
LGG	chr12	49055279	Missense_Mutation	novel	A16T	0.32
LGG	chr12	49052607	Silent	NA	Q405Q	0.57
LGG	chr12	49037294	Silent	novel	G3354G	0.07
LIHC	chr12	49034167	Missense_Mutation	rs775632051	R3547H	0.5
LIHC	chr12	49040053	Missense_Mutation	novel	G2573S	0.15
LIHC	chr12	49022279	Splice_Site	rs794727752	X5471_splice	0.21
LIHC	chr12	49033636	Missense_Mutation	novel	G3690V	0.26
LIHC	chr12	49033637	Missense_Mutation	novel	G3690R	0.26
LIHC	chr12	49037559	Missense_Mutation	NA	L3266H	0.19
LIHC	chr12	49039559	Missense_Mutation	novel	Q2702L	0.45
LIHC	chr12	49037395	Nonsense_Mutation	rs793888512	R3321*	0.19
LIHC	chr12	49026260	Missense_Mutation	NA	N5236H	0.47
LIHC	chr12	49052062	Missense_Mutation	novel	E541K	0.19
LIHC	chr12	49046062	Splice_Region	novel		0.43
LIHC	chr12	49052239	Missense_Mutation	novel	A482T	0.33
LIHC	chr12	49049816	Missense_Mutation	NA	R1258W	0.42
LIHC	chr12	49031453	Frame_Shift_Del	novel	*E4418Nfs14**	0.35
LIHC	chr12	49038072	Missense_Mutation	NA	G3095D	0.42
LIHC	chr12	49022743	Missense_Mutation	novel	W5395C	0.46
LIHC	chr12	49038240	Missense_Mutation	NA	D3039G	0.44
LIHC	chr12	49033010	Nonsense_Mutation	novel	Q3899*	0.45
LIHC	chr12	49033896	Silent	NA	Q3603Q	0.09
LIHC	chr12	49046776	Missense_Mutation	novel	M1417I	0.38
LIHC	chr12	49039307	Silent	NA	L2761L	0.51
LIHC	chr12	49033896	Silent	NA	Q3603Q	0.14
LIHC	chr12	49055310	Frame_Shift_Del	novel	*S3Tfs4**	0.34
LIHC	chr12	49033896	Silent	NA	Q3603Q	0.09
LIHC	chr12	49033311	Silent	novel	P3798P	0.08
LIHC	chr12	49050099	Silent	NA	V1163V	0.15
LIHC	chr12	49031279	Frame_Shift_Del	novel	*T4476Lfs43**	0.51
LUAD	chr12	49053531	Missense_Mutation	NA	A262S	0.33
LUAD	chr12	49022647	Missense_Mutation	NA	I5427M	0.04
LUAD	chr12	49039788	Missense_Mutation	novel	L2661H	0.17
LUAD	chr12	49041332	Silent	novel	P2146P	0.2
LUAD	chr12	49051021	Missense_Mutation	NA	E888K	0.05
LUAD	chr12	49044845	Missense_Mutation	novel	P1621L	0.1
LUAD	chr12	49031749	Missense_Mutation	novel	R4319I	0.57
LUAD	chr12	49051681	Nonsense_Mutation	NA	E668*	0.42
LUAD	chr12	49051682	Missense_Mutation	novel	E667D	0.4
LUAD	chr12	49044239	Nonsense_Mutation	novel	Q1717*	0.17
LUAD	chr12	49046425	Splice_Site	NA	X1473_splice	0.06
LUAD	chr12	49040709	Frame_Shift_Del	NA	*P2354Lfs30**	0.08
LUAD	chr12	49038614	Missense_Mutation	NA	H2914Q	0.36
LUAD	chr12	49051450	Missense_Mutation	NA	P745S	0.28
LUAD	chr12	49040902	Frame_Shift_Del	novel	*E2290Kfs32**	0.41
LUAD	chr12	49028876	Missense_Mutation	novel	K4778N	0.16
LUAD	chr12	49051157	Silent	novel	L842L	0.13
LUAD	chr12	49048011	Missense_Mutation	novel	C1397Y	0.07
LUAD	chr12	49032113	Nonsense_Mutation	rs587783685	R4198*	0.24
LUAD	chr12	49040944	Missense_Mutation	rs368486128	P2276S	0.42
LUAD	chr12	49028901	Missense_Mutation	NA	P4770L	0.28
LUAD	chr12	49044234	Silent	NA	A1718A	0.33
LUAD	chr12	49031244	Silent	novel	I4487I	0.06
LUAD	chr12	49052390	Missense_Mutation	novel	E431D	0.22
LUAD	chr12	49026341	Missense_Mutation	novel	G5209C	0.34
LUAD	chr12	49048731	Silent	NA	E1353E	0.11
LUAD	chr12	49043384	Nonsense_Mutation	NA	E1838*	0.12
LUAD	chr12	49044248	Missense_Mutation	NA	P1714S	0.33
LUAD	chr12	49046159	Silent	NA	G1533G	0.2
LUAD	chr12	49039968	Missense_Mutation	NA	T2601I	0.39
LUAD	chr12	49034226	Silent	novel	V3527V	0.18
LUAD	chr12	49051357	Nonsense_Mutation	NA	E776*	0.33
LUAD	chr12	49050776	Missense_Mutation	NA	P938A	0.36
LUAD	chr12	49052143	Missense_Mutation	NA	P514S	0.22
LUAD	chr12	49031704	Missense_Mutation	novel	A4334D	0.33
LUAD	chr12	49026984	Silent	novel	L4994L	0.12
LUAD	chr12	49051078	Missense_Mutation	novel	E869K	0.35
LUAD	chr12	49052159	Silent	novel	E508E	0.35
LUAD	chr12	49040777	Silent	NA	L2331L	0.45
LUAD	chr12	49026411	Silent	rs575965702	F5185F	0.19
LUAD	chr12	49042593	Silent	novel	P1945P	0.17
LUAD	chr12	49053534	Missense_Mutation	novel	T261S	0.33
LUAD	chr12	49050558	Silent	NA	G1010G	0.48
LUAD	chr12	49053604	Silent	rs192397485	E237E	0.56
LUAD	chr12	49028855	Missense_Mutation	novel	M4785I	0.4
LUAD	chr12	49026212	Missense_Mutation	NA	D5252Y	0.13
LUAD	chr12	49044474	Missense_Mutation	novel	S1671I	0.15
LUAD	chr12	49052309	Silent	novel	T458T	0.13
LUAD	chr12	49051504	Missense_Mutation	NA	P727S	0.35
LUAD	chr12	49049714	Missense_Mutation	rs762841102	R1292C	0.06
LUAD	chr12	49050261	Silent	NA	A1109A	0.17
LUAD	chr12	49026488	Missense_Mutation	NA	D5160H	0.33
LUAD	chr12	49038460	Missense_Mutation	NA	R2966W	0.38
LUAD	chr12	49042591	Missense_Mutation	NA	G1946A	0.21
LUSC	chr12	49047978	Missense_Mutation	NA	C1408F	0.36
LUSC	chr12	49027323	Splice_Site	novel	X4882_splice	0.6
LUSC	chr12	49029237	Splice_Site	novel	X4692_splice	0.27
LUSC	chr12	49050574	Missense_Mutation	rs371286331	P1005L	0.19
LUSC	chr12	49032615	Frame_Shift_Del	novel	*Q4026Pfs9**	0.11
LUSC	chr12	49046756	Missense_Mutation	novel	C1424S	0.11
LUSC	chr12	49032079	Frame_Shift_Del	novel	*P4209Tfs124**	0.18
LUSC	chr12	49031890	Missense_Mutation	rs763518333	G4272D	0.44
LUSC	chr12	49050595	Frame_Shift_Del	NA	*P998Lfs2**	0.19
LUSC	chr12	49040835	Nonsense_Mutation	NA	S2312*	0.28
LUSC	chr12	49038176	Silent	novel	G3060G	0.11
LUSC	chr12	49039976	Frame_Shift_Del	novel	*S2590Wfs56**	0.32
LUSC	chr12	49038132	Missense_Mutation	NA	S3075L	0.31
LUSC	chr12	49051554	Frame_Shift_Ins	novel	*P710Hfs21**	0.42
LUSC	chr12	49037744	Silent	NA	P3204P	0.39
LUSC	chr12	49034848	Frame_Shift_Del	novel	*A3440Vfs11**	0.26
LUSC	chr12	49040825	Missense_Mutation	rs764686162	H2315Q	0.16
LUSC	chr12	49033514	Missense_Mutation	novel	A3731S	0.29
LUSC	chr12	49041474	Missense_Mutation	novel	R2099L	0.36
LUSC	chr12	49026421	Frame_Shift_Del	NA	*G5182Afs61**	0.1
LUSC	chr12	49050437	Missense_Mutation	NA	V1051I	0.23
LUSC	chr12	49052023	Silent	novel	L554L	0.09
LUSC	chr12	49050979	Nonsense_Mutation	novel	E902*	0.12
LUSC	chr12	49038108	Frame_Shift_Del	novel	*R3082Gfs14**	0.22
LUSC	chr12	49049886	Silent	novel	G1234G	0.4
LUSC	chr12	49039604	Frame_Shift_Del	novel	*R2687Qfs4**	0.4
LUSC	chr12	49038675	Missense_Mutation	rs771221036	P2894L	0.38
LUSC	chr12	49046089	Nonsense_Mutation	novel	Q1557*	0.5
LUSC	chr12	49051360	Nonsense_Mutation	novel	E775*	0.23
LUSC	chr12

EuRBPDB

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