EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26366712	Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis.	Nat Med	2015 Oct	Zhang J	doi: 10.1038/nm.3940
25112956	Exome sequencing identifies frequent mutation of MLL2 in non-small cell lung carcinoma from Chinese patients.	Sci Rep	2014 Aug 12	Yin S	doi: 10.1038/srep06036.
26366710	The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development.	Nat Med	2015 Oct	Ortega-Molina A	doi: 10.1038/nm.3943
29532228	High MLL2 expression predicts poor prognosis and promotes tumor progression by inducing EMT in esophageal squamous cell carcinoma.	J Cancer Res Clin Oncol	2018 Jun	Abudureheman A	doi: 10.1007/s00432-018-2625-5
29627316	KMT2D Mutation Is Associated With Poor Prognosis in Non-Small-Cell Lung Cancer.	Clin Lung Cancer	2018 Jul	Ardeshir-Larijani F	doi: 10.1016/j.cllc.2018.03.005
16603732	Identification of the MLL2 complex as a coactivator for estrogen receptor alpha.	J Biol Chem	2006 Jun 9	Mo R	-
24491801	UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells.	Cancer Res	2014 Mar 15	Kim JH	doi: 10.1158/0008-5472.CAN-13-1896
20937768	Pygo2 associates with MLL2 histone methyltransferase and GCN5 histone acetyltransferase complexes to augment Wnt target gene expression and breast cancer stem-like cell expansion.	Mol Cell Biol	2010 Dec	Chen J	doi: 10.1128/MCB.00465-10
28336670	PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D.	Science	2017 Mar 24	Toska E	doi: 10.1126/science.aah6893.
28007623	Small Cell Lung Cancer Exhibits Frequent Inactivating Mutations in the Histone Methyltransferase KMT2D/MLL2: CALGB 151111 (Alliance).	J Thorac Oncol	2017 Apr	Augert A	doi: 10.1016/j.jtho.2016.12.011
27387124	Single-cell Sequencing Reveals Variants in ARID1A, GPRC5A and MLL2 Driving Self-renewal of Human Bladder Cancer Stem Cells.	Eur Urol	2017 Jan	Yang Z	doi: 10.1016/j.eururo.2016.06.025
29269867	Histone methyltransferase KMT2D sustains prostate carcinogenesis and metastasis via epigenetically activating LIFR and KLF4.	Oncogene	2018 Mar	Lv S	doi: 10.1038/s41388-017-0026-x
30177394	Downregulation of KMT2D suppresses proliferation and induces apoptosis of gastric cancer.	Biochem Biophys Res Commun	2018 Sep 26	Xiong W	doi: 10.1016/j.bbrc.2018.08.143

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr12	49051423	Missense_Mutation	novel	P754A	0.25
ACC	chr12	49022643	Missense_Mutation	novel	T5429A	0.12
ACC	chr12	49043922	Silent	novel	Q1755Q	0.44
ACC	chr12	49027846	Missense_Mutation	novel	Y4867C	0.25
ACC	chr12	49051769	Silent	novel	P638P	0.72
ACC	chr12	49040709	Frame_Shift_Del	NA	*P2354Lfs30**	0.59
ACC	chr12	49026390	Silent	rs779137584	L5192L	0.49
BLCA	chr12	49050383	Nonsense_Mutation	novel	E1069*	0.14
BLCA	chr12	49051252	Nonsense_Mutation	novel	E811*	0.09
BLCA	chr12	49026764	Missense_Mutation	novel	E5068K	0.35
BLCA	chr12	49049727	Silent	novel	E1287E	0.22
BLCA	chr12	49034174	Nonsense_Mutation	novel	K3545*	0.32
BLCA	chr12	49052961	Nonsense_Mutation	NA	Q356*	0.28
BLCA	chr12	49050536	Nonsense_Mutation	NA	E1018*	0.41
BLCA	chr12	49037954	Silent	novel	F3134F	0.42
BLCA	chr12	49051149	Frame_Shift_Ins	rs767415197	*R845Pfs3**	0.27
BLCA	chr12	49052579	Nonsense_Mutation	NA	E415*	0.24
BLCA	chr12	49039434	Splice_Site	novel	X2743_splice	0.4
BLCA	chr12	49034146	Frame_Shift_Del	novel	G3553*	0.41
BLCA	chr12	49049851	Missense_Mutation	rs112921115	T1246M	0.52
BLCA	chr12	49051287	Frame_Shift_Del	novel	*P799Lfs131**	0.49
BLCA	chr12	49053073	Splice_Site	NA	X319_splice	0.32
BLCA	chr12	49051569	Nonsense_Mutation	novel	S705*	0.1
BLCA	chr12	49051974	Missense_Mutation	NA	S570C	0.07
BLCA	chr12	49027883	Missense_Mutation	novel	D4855H	0.44
BLCA	chr12	49028142	Splice_Site	NA	X4795_splice	0.31
BLCA	chr12	49029232	Nonsense_Mutation	novel	E4694*	0.43
BLCA	chr12	49030343	Missense_Mutation	novel	E4646K	0.43
BLCA	chr12	49053287	Missense_Mutation	novel	E292K	0.13
BLCA	chr12	49026431	Missense_Mutation	rs794727688	R5179C	0.58
BLCA	chr12	49039311	Frame_Shift_Del	novel	*I2760Sfs27**	0.44
BLCA	chr12	49040838	Missense_Mutation	novel	S2311F	0.42
BLCA	chr12	49042179	Nonsense_Mutation	novel	E2007*	0.21
BLCA	chr12	49040778	Frame_Shift_Del	novel	F2327*	0.32
BLCA	chr12	49021845	Missense_Mutation	novel	E5517Q	0.37
BLCA	chr12	49026381	Silent	novel	Q5195Q	0.37
BLCA	chr12	49031315	Nonsense_Mutation	NA	Q4464*	0.42
BLCA	chr12	49032033	Frame_Shift_Ins	novel	*L4225Tfs109**	0.1
BLCA	chr12	49050608	Nonsense_Mutation	novel	E994*	0.15
BLCA	chr12	49051387	Missense_Mutation	novel	E766K	0.1
BLCA	chr12	49041035	Silent	NA	L2245L	0.25
BLCA	chr12	49027307	Nonsense_Mutation	rs793888513	E4887*	0.2
BLCA	chr12	49039582	Missense_Mutation	novel	Q2694H	0.21
BLCA	chr12	49047968	Silent	novel	S1411S	0.19
BLCA	chr12	49051603	Missense_Mutation	novel	E694K	0.15
BLCA	chr12	49054564	Missense_Mutation	novel	E122K	0.27
BLCA	chr12	49032572	Nonsense_Mutation	novel	Q4045*	0.53
BLCA	chr12	49039221	Splice_Site	novel	X2789_splice	0.17
BLCA	chr12	49053038	Nonsense_Mutation	novel	S330*	0.04
BLCA	chr12	49049964	Missense_Mutation	novel	I1208M	0.39
BLCA	chr12	49026337	Missense_Mutation	novel	Y5210S	0.33
BLCA	chr12	49031921	Nonsense_Mutation	NA	Q4262*	0.14
BLCA	chr12	49033850	Missense_Mutation	novel	L3619F	0.47
BLCA	chr12	49044840	Missense_Mutation	rs754087735	E1623K	0.29
BLCA	chr12	49022769	Nonsense_Mutation	NA	Q5387*	0.59
BLCA	chr12	49051738	Nonsense_Mutation	novel	E649*	0.09
BLCA	chr12	49026185	Nonsense_Mutation	NA	Q5261*	0.37
BLCA	chr12	49028936	Nonsense_Mutation	novel	Y4758*	0.42
BLCA	chr12	49050730	Frame_Shift_Del	novel	*P949Lfs5**	0.45
BLCA	chr12	49050718	Nonsense_Mutation	novel	L957*	0.54
BLCA	chr12	49052992	Silent	novel	L345L	0.5
BLCA	chr12	49026905	Nonsense_Mutation	rs587783695	R5021*	0.14
BLCA	chr12	49052996	Missense_Mutation	novel	S344C	0.06
BLCA	chr12	49022144	Frame_Shift_Ins	novel	N5474*	0.39
BLCA	chr12	49034067	Frame_Shift_Del	novel	*S3572Rfs78**	0.15
BLCA	chr12	49050359	Nonsense_Mutation	NA	K1077*	0.16
BLCA	chr12	49026249	Silent	rs543419394	P5239P	0.57
BLCA	chr12	49031386	Frame_Shift_Ins	novel	*I4440Nfs47**	0.51
BLCA	chr12	49054619	Frame_Shift_Ins	novel	*G104Rfs4**	0.58
BLCA	chr12	49040632	Nonsense_Mutation	NA	Q2380*	0.32
BLCA	chr12	49039434	Splice_Site	novel	X2743_splice	0.22
BLCA	chr12	49039435	Missense_Mutation	novel	Q2743H	0.22
BLCA	chr12	49039611	Nonsense_Mutation	rs587783727	R2685*	0.23
BLCA	chr12	49050885	Splice_Site	rs727503988	X933_splice	0.41
BLCA	chr12	49050901	Nonsense_Mutation	NA	Q928*	0.16
BLCA	chr12	49028075	Missense_Mutation	novel	V4817M	0.23
BLCA	chr12	49026458	Nonsense_Mutation	NA	Q5170*	0.12
BLCA	chr12	49037187	Missense_Mutation	novel	C3390F	0.35
BLCA	chr12	49030685	Frame_Shift_Del	novel	C4583*	0.29
BLCA	chr12	49052113	Frame_Shift_Del	novel	*E524Kfs406**	0.25
BLCA	chr12	49051198	Missense_Mutation	novel	E829Q	0.2
BLCA	chr12	49040835	Missense_Mutation	NA	S2312L	0.27
BLCA	chr12	49024896	Missense_Mutation	novel	D5279N	0.3
BLCA	chr12	49032590	Missense_Mutation	novel	E4039K	0.39
BLCA	chr12	49031255	Nonsense_Mutation	rs587783690	R4484*	0.22
BLCA	chr12	49052026	Missense_Mutation	novel	P553A	0.13
BLCA	chr12	49044249	Frame_Shift_Del	novel	*G1713Afs21**	0.2
BLCA	chr12	49031341	Missense_Mutation	rs372839823	R4455H	0.25
BLCA	chr12	49030632	Frame_Shift_Ins	novel	*G4603Afs5**	0.5
BLCA	chr12	49030376	Nonsense_Mutation	NA	Q4635*	0.35
BLCA	chr12	49027207	Frame_Shift_Del	novel	*S4915Lfs11**	0.68
BLCA	chr12	49038257	Frame_Shift_Del	novel	*N3034Mfs37**	0.18
BLCA	chr12	49026878	Missense_Mutation	NA	R5030C	0.28
BLCA	chr12	49054665	Frame_Shift_Del	novel	*P88Hfs42**	0.5
BLCA	chr12	49038552	Nonsense_Mutation	NA	S2935*	0.05
BLCA	chr12	49039883	Frame_Shift_Del	novel	*P2619Mfs61**	0.64
BLCA	chr12	49030919	Missense_Mutation	novel	E4549K	0.21
BLCA	chr12	49039867	Nonsense_Mutation	rs794727549	R2635*	0.28
BLCA	chr12	49026266	Nonsense_Mutation	novel	E5234*	0.37
BLCA	chr12	49031695	Frame_Shift_Del	novel	*P4337Lfs47**	0.55
BLCA	chr12	49049146	Frame_Shift_Del	novel	*A1327Pfs3**	0.25
BLCA	chr12	49054922	Nonsense_Mutation	novel	Q52*	0.55
BLCA	chr12	49052940	Nonsense_Mutation	novel	E363*	0.2
BLCA	chr12	49026887	Nonsense_Mutation	rs797045659	R5027*	0.37
BLCA	chr12	49024636	Missense_Mutation	rs763696810	M5332V	0.44
BLCA	chr12	49026950	Nonsense_Mutation	novel	E5006*	0.18
BLCA	chr12	49042587	Silent	novel	L1947L	0.19
BLCA	chr12	49054674	Missense_Mutation	NA	F85S	0.2
BLCA	chr12	49043867	Splice_Site	novel	X1773_splice	0.38
BLCA	chr12	49046264	Nonsense_Mutation	novel	E1527*	0.38
BLCA	chr12	49041002	Frame_Shift_Del	novel	*L2255Cfs3**	0.37
BLCA	chr12	49032119	Nonsense_Mutation	novel	Q4196*	0.25
BLCA	chr12	49033655	Nonsense_Mutation	novel	Q3684*	0.23
BLCA	chr12	49026559	Frame_Shift_Ins	novel	*H5136Rfs12**	0.45
BLCA	chr12	49053259	Frame_Shift_Del	novel	*F301Sfs3**	0.48
BLCA	chr12	49054922	Nonsense_Mutation	novel	Q52*	0.23
BLCA	chr12	49050389	Missense_Mutation	novel	E1067K	0.44
BLCA	chr12	49026277	Missense_Mutation	NA	C5230F	0.42
BLCA	chr12	49031666	Nonsense_Mutation	NA	Q4347*	0.25
BLCA	chr12	49026381	Missense_Mutation	NA	Q5195H	0.44
BLCA	chr12	49026655	Missense_Mutation	NA	C5104Y	0.47
BLCA	chr12	49042646	Splice_Site	novel	X1928_splice	0.37
BLCA	chr12	49042879	Splice_Site	novel	X1882_splice	0.23
BLCA	chr12	49022104	Missense_Mutation	novel	T5487K	0.11
BLCA	chr12	49047983	Frame_Shift_Ins	novel	*Y1407Lfs25**	0.32
BLCA	chr12	49051883	Silent	novel	F600F	0.22
BLCA	chr12	49052710	Splice_Site	novel	X371_splice	0.25
BLCA	chr12	49037741	Silent	novel	G3205G	0.19
BLCA	chr12	49037742	Missense_Mutation	NA	G3205V	0.19
BLCA	chr12	49042158	Nonsense_Mutation	NA	Q2014*	0.5
BLCA	chr12	49032746	Frame_Shift_Ins	novel	*P3987Ifs36**	0.22
BLCA	chr12	49033807	Missense_Mutation	novel	G3633V	0.55
BLCA	chr12	49026430	Missense_Mutation	rs267607237	R5179H	0.4
BLCA	chr12	49029164	Silent	novel	G4716G	0.34
BLCA	chr12	49024687	Nonsense_Mutation	rs587783699	Q5315*	0.22
BLCA	chr12	49030674	Frame_Shift_Del	novel	*V4585Afs3**	0.29
BLCA	chr12	49039940	Frame_Shift_Del	novel	*G2606Afs80**	0.43
BLCA	chr12	49050521	Nonsense_Mutation	novel	Q1023*	0.3
BLCA	chr12	49052914	Splice_Site	novel	X371_splice	0.27
BLCA	chr12	49053487	Silent	NA	C276C	0.29
BLCA	chr12	49050394	Missense_Mutation	novel	S1065L	0.15
BLCA	chr12	49030958	Nonsense_Mutation	rs587783692	R4536*	0.23
BLCA	chr12	49040542	Nonsense_Mutation	NA	R2410*	0.55
BLCA	chr12	49027307	Missense_Mutation	novel	E4887Q	0.31
BLCA	chr12	49031855	Nonsense_Mutation	NA	Q4284*	0.52
BLCA	chr12	49034846	Nonsense_Mutation	novel	Q3441*	0.41
BLCA	chr12	49050889	Nonsense_Mutation	novel	*P932Sfs2**	0.41
BLCA	chr12	49028883	Missense_Mutation	novel	K4776R	0.05
BLCA	chr12	49022302	Missense_Mutation	novel	T5464P	0.25
BLCA	chr12	49026625	Missense_Mutation	novel	H5114R	0.48
BLCA	chr12	49040957	Silent	NA	P2271P	0.17
BLCA	chr12	49042620	Frame_Shift_Del	novel	*S1937Pfs110**	0.46
BLCA	chr12	49022073	In_Frame_Del	rs587783704	I5497del	0.73
BLCA	chr12	49031437	Frame_Shift_Del	novel	*P4423Hfs9**	0.34
BLCA	chr12	49040998	Frame_Shift_Del	novel	V2257*	0.38
BLCA	chr12	49033343	Nonsense_Mutation	NA	Q3788*	0.45
BLCA	chr12	49022308	Missense_Mutation	NA	D5462H	0.16
BLCA	chr12	49032017	Nonsense_Mutation	rs793888511	Q4230*	0.53
BLCA	chr12	49037813	Missense_Mutation	NA	E3181D	0.52
BLCA	chr12	49038340	Missense_Mutation	NA	D3006N	0.46
BLCA	chr12	49040995	Missense_Mutation	NA	E2259K	0.35
BLCA	chr12	49051481	Silent	NA	L734L	0.17
BLCA	chr12	49039611	Nonsense_Mutation	rs587783727	R2685*	0.16
BLCA	chr12	49040524	Nonsense_Mutation	NA	Q2416*	0.57
BLCA	chr12	49028874	Missense_Mutation	novel	G4779V	0.25
BLCA	chr12	49053642	Splice_Site	novel	X225_splice	0.31
BLCA	chr12	49046301	Nonsense_Mutation	NA	Y1514*	0.52
BLCA	chr12	49032322	Missense_Mutation	novel	S4128L	0.19
BLCA	chr12	49044253	Frame_Shift_Del	novel	*K1712Rfs10**	0.64
BLCA	chr12	49051366	Frame_Shift_Del	novel	*Q773Sfs157**	0.24
BLCA	chr12	49026420	Frame_Shift_Ins	NA	*L5183Pfs16**	0.23
BLCA	chr12	49022308	Missense_Mutation	NA	D5462H	0.17
BLCA	chr12	49027020	Nonsense_Mutation	novel	W4982*	0.33
BLCA	chr12	49027232	Missense_Mutation	novel	E4912K	0.37
BLCA	chr12	49031762	Nonsense_Mutation	novel	Q4315*	0.26
BLCA	chr12	49031295	Missense_Mutation	NA	K4470N	0.39
BLCA	chr12	49034123	Nonsense_Mutation	NA	E3562*	0.42
BLCA	chr12	49044812	Nonsense_Mutation	NA	S1632*	0.43
BLCA	chr12	49050901	Nonsense_Mutation	NA	Q928*	0.15
BLCA	chr12	49054656	Nonsense_Mutation	novel	W91*	0.44
BLCA	chr12	49033715	Frame_Shift_Del	novel	*M3662Ifs11**	0.22
BRCA	chr12	49051550	Silent	NA	P711P	0.31
BRCA	chr12	49042626	Silent	novel	N1934N	0.1
BRCA	chr12	49032991	Missense_Mutation	NA	Q3905L	0.13
BRCA	chr12	49041436	Frame_Shift_Del	NA	*A2112Hfs32**	0.47
BRCA	chr12	49053026	Missense_Mutation	NA	N334I	0.38
BRCA	chr12	49043414	Missense_Mutation	NA	D1828H	0.13
BRCA	chr12	49042568	Missense_Mutation	NA	D1954H	0.25
BRCA	chr12	49051763	In_Frame_Ins	novel	D632_E640dup	0.04
BRCA	chr12	49050986	Silent	NA	A899A	0.57
BRCA	chr12	49037651	Missense_Mutation	NA	K3235N	0.25
BRCA	chr12	49050975	Missense_Mutation	novel	P903L	0.07
BRCA	chr12	49033123	In_Frame_Del	novel	Q3861_Q3863del	0.68
BRCA	chr12	49033945	Missense_Mutation	NA	E3587V	0.58
BRCA	chr12	49046715	Missense_Mutation	NA	D1438N	0.38
BRCA	chr12	49052126	Frame_Shift_Del	NA	*L520Cfs410**	0.35
BRCA	chr12	49040889	Frame_Shift_Del	novel	*L2292Hfs28**	0.83
BRCA	chr12	49030733	Silent	NA	I4569I	0.12
BRCA	chr12	49034647	Missense_Mutation	novel	A3459S	0.1
BRCA	chr12	49034609	Missense_Mutation	novel	Q3471H	0.19
BRCA	chr12	49027833	Missense_Mutation	NA	S4871R	0.17
BRCA	chr12	49028946	Frame_Shift_Ins	novel	*T4755Nfs27**	0.09
BRCA	chr12	49033829	Missense_Mutation	rs766696812	R3626W	0.33
BRCA	chr12	49024634	Missense_Mutation	NA	M5332I	0.26
BRCA	chr12	49050527	Missense_Mutation	NA	P1021S	0.13
BRCA	chr12	49037692	Frame_Shift_Del	novel	*L3220Wfs9**	0.17
BRCA	chr12	49033837	In_Frame_Del	NA	Q3623del	0.31
BRCA	chr12	49041006	Nonsense_Mutation	novel	L2255*	0.5
BRCA	chr12	49042191	Missense_Mutation	novel	L2003V	0.07
BRCA	chr12	49046370	Nonsense_Mutation	novel	W1491*	0.45
BRCA	chr12	49031295	Missense_Mutation	NA	K4470N	0.3
BRCA	chr12	49030949	Frame_Shift_Ins	novel	*L4539Ffs15**	0.49
BRCA	chr12	49033411	Missense_Mutation	NA	T3765R	0.19
BRCA	chr12	49021615	3'UTR	novel		1
BRCA	chr12	49033174	Missense_Mutation	NA	G3844V	0.14
BRCA	chr12	49034636	Silent	NA	L3462L	0.33
BRCA	chr12	49043695	Frame_Shift_Ins	novel	*T1803Yfs23**	0.1
BRCA	chr12	49033961	Missense_Mutation	NA	R3582W	0.55
BRCA	chr12	49043178	Missense_Mutation	NA	D1848N	0.24
BRCA	chr12	49034167	Missense_Mutation	rs775632051	R3547H	0.46
BRCA	chr12	49051376	Silent	NA	H769H	0.14
BRCA	chr12	49053990	Frame_Shift_Del	NA	*A221Lfs40**	0.15
BRCA	chr12	49044444	Missense_Mutation	novel	T1681N	0.21
BRCA	chr12	49031629	Missense_Mutation	novel	S4359L	0.1
CESC	chr12	49020342	3'UTR	novel		0.37
CESC	chr12	49040177	Frame_Shift_Del	NA	*S2532Lfs11**	0.12
CESC	chr12	49026836	Missense_Mutation	NA	D5044N	0.41
CESC	chr12	49027049	Missense_Mutation	NA	D4973H	0.38
CESC	chr12	49030768	Missense_Mutation	NA	E4558Q	0.28
CESC	chr12	49031276	Missense_Mutation	NA	G4477R	0.26
CESC	chr12	49026224	Nonsense_Mutation	NA	Q5248*	0.47
CESC	chr12	49022769	Nonsense_Mutation	NA	Q5387*	0.15
CESC	chr12	49046724	Nonsense_Mutation	novel	Q1435*	0.44
CESC	chr12	49045940	Missense_Mutation	NA	P1574L	0.15
CESC	chr12	49031855	Nonsense_Mutation	NA	Q4284*	0.15
CESC	chr12	49040578	Missense_Mutation	rs200238459	L2398V	0.08
CESC	chr12	49019904	3'UTR	novel		0.21
CESC	chr12	49053291	Silent	NA	V290V	0.41
CESC	chr12	49037394	Missense_Mutation	rs753081311	R3321Q	0.5
CESC	chr12	49026421	Frame_Shift_Del	NA	*G5182Afs61**	0.5
CESC	chr12	49032726	Silent	novel	Q3993Q	0.11
CESC	chr12	49038059	Silent	rs368160122	R3099R	0.4
CESC	chr12	49032991	Missense_Mutation	NA	Q3905L	0.09
CESC	chr12	49037612	Silent	NA	L3248L	0.32
CESC	chr12	49047997	Nonsense_Mutation	NA	Q1402*	0.36
CESC	chr12	49026626	Missense_Mutation	NA	H5114Y	0.38
CESC	chr12	49040835	Nonsense_Mutation	NA	S2312*	0.36
CESC	chr12	49041687	Missense_Mutation	NA	R2068W	0.22
CESC	chr12	49044828	Missense_Mutation	NA	E1627K	0.3
CESC	chr12	49046367	Silent	NA	Q1492Q	0.18
CESC	chr12	49048727	Missense_Mutation	NA	E1355K	0.2
CESC	chr12	49048757	Missense_Mutation	NA	D1345H	0.37
CESC	chr12	49048763	Missense_Mutation	NA	D1343N	0.16
CESC	chr12	49034241	Silent	NA	Q3522Q	0.33
CESC	chr12	49044257	Nonsense_Mutation	rs794727342	K1711*	0.32
CESC	chr12	49040844	Nonsense_Mutation	NA	S2309*	0.42
CESC	chr12	49032686	Nonsense_Mutation	NA	Q4007*	0.79
CESC	chr12	49020717	3'UTR	novel		0.14
CESC	chr12	49039728	Missense_Mutation	rs779506886	R2681Q	0.11
CESC	chr12	49032299	Frame_Shift_Del	novel	*Q4136Afs31**	0.08
CESC	chr12	49034846	Nonsense_Mutation	novel	Q3441*	0.57
CESC	chr12	49051048	Nonsense_Mutation	novel	E879*	0.36
CESC	chr12	49026709	Missense_Mutation	rs775506569	R5086Q	0.31
CESC	chr12	49040613	Missense_Mutation	rs763262491	R2386Q	0.24
CESC	chr12	49051576	Missense_Mutation	novel	E703K	0.41
CESC	chr12	49039307	Silent	NA	L2761L	0.7
CESC	chr12	49027061	Nonsense_Mutation	NA	E4969*	0.13
CESC	chr12	49040473	Nonsense_Mutation	NA	E2433*	0.15
CESC	chr12	49043740	Missense_Mutation	rs755651886	A1788T	0.18
CESC	chr12	49021177	3'UTR	novel		0.16
CESC	chr12	49031861	Nonsense_Mutation	NA	R4282*	0.54
CESC	chr12	49040632	Nonsense_Mutation	NA	Q2380*	0.38
CESC	chr12	49038094	Missense_Mutation	novel	G3088W	0.09
CESC	chr12	49020006	3'UTR	novel		0.34
CESC	chr12	49021797	Missense_Mutation	novel	R5533W	0.39
CESC	chr12	49026280	Missense_Mutation	rs201628357	R5229H	0.38
CESC	chr12	49027256	Nonsense_Mutation	rs398123721	R4904*	0.37
CESC	chr12	49050905	Silent	NA	S926S	0.39
CESC	chr12	49040220	Frame_Shift_Del	novel	*S2512Ifs26**	0.15
CESC	chr12	49033328	Nonsense_Mutation	NA	Q3793*	0.67
CESC	chr12	49040797	Missense_Mutation	NA	D2325N	0.32
CESC	chr12	49037176	Nonsense_Mutation	NA	Q3394*	0.13
CESC	chr12	49019503	3'UTR	novel		0.27
CESC	chr12	49055008	Missense_Mutation	novel	S23F	0.26
CESC	chr12	49047997	Nonsense_Mutation	NA	Q1402*	0.35
CESC	chr12	49040770	Missense_Mutation	novel	R2334W	0.21
CESC	chr12	49032517	Missense_Mutation	novel	G4063E	0.14
CESC	chr12	49050503	Nonsense_Mutation	NA	Q1029*	0.5
CESC	chr12	49044299	Missense_Mutation	novel	G1697C	0.31
CESC	chr12	49028142	Splice_Site	NA	X4795_splice	0.37
CESC	chr12	49033812	Silent	NA	L3631L	0.25
CESC	chr12	49034069	Nonsense_Mutation	NA	Q3580*	0.34
CESC	chr12	49024637	Silent	novel	L5331L	0.36
CESC	chr12	49024882	Silent	novel	L5283L	0.43
CESC	chr12	49026899	Missense_Mutation	novel	D5023N	0.3
CESC	chr12	49032990	Silent	NA	Q3905Q	0.42
CESC	chr12	49024896	Missense_Mutation	NA	D5279Y	0.41
CESC	chr12	49038246	Frame_Shift_Ins	novel	*H3037Pfs4**	0.5
CESC	chr12	49041012	Frame_Shift_Del	novel	*K2246Ifs11**	0.65
CESC	chr12	49019656	3'UTR	novel		0.12
CESC	chr12	49048739	Nonsense_Mutation	novel	E1351*	0.26
CESC	chr12	49042560	Splice_Site	NA	X1956_splice	0.15
CESC	chr12	49037177	Silent	rs368612015	P3393P	0.44
CESC	chr12	49026690	Nonsense_Mutation	novel	C5092*	0.16
CESC	chr12	49054351	Missense_Mutation	novel	E156K	0.29
CESC	chr12	49054564	Nonsense_Mutation	novel	E122*	0.29
CHOL	chr12	49054311	Nonsense_Mutation	novel	S169*	0.14
CHOL	chr12	49024860	Missense_Mutation	NA	E5291K	0.11
CHOL	chr12	49032784	In_Frame_Del	novel	Q3953_Q3974del	0.32
CHOL	chr12	49032842	In_Frame_Del	novel	Q3938_Q3954del	0.25
COAD	chr12	49038842	Silent	NA	P2838P	0.28
COAD	chr12	49040709	Frame_Shift_Del	NA	*P2354Lfs30**	0.12
COAD	chr12	49041416	Frame_Shift_Del	NA	*A2119Lfs25**	0.13
COAD	chr12	49049188	Missense_Mutation	rs769189340	R1313W	0.27
COAD	chr12	49048762	Missense_Mutation	NA	D1343G	0.4
COAD	chr12	49051743	Frame_Shift_Del	NA	*P647Hfs283**	0.23
COAD	chr12	49024578	Missense_Mutation	NA	R5351L	0.25
COAD	chr12	49032500	Missense_Mutation	NA	L4069V	0.23
COAD	chr12	49033097	Missense_Mutation	NA	M3870V	0.18
COAD	chr12	49044426	Missense_Mutation	NA	R1687H	0.11
COAD	chr12	49042745	Silent	NA	L1926L	0.34
COAD	chr12	49033896	Silent	NA	Q3603Q	0.06
COAD	chr12	49033884	Silent	NA	Q3607Q	0.33
COAD	chr12	49049814	Silent	NA	R1258R	0.18
COAD	chr12	49029214	Missense_Mutation	rs369583907	D4700N	0.25
COAD	chr12	49037178	Missense_Mutation	rs754209328	P3393L	0.26
COAD	chr12	49040709	Frame_Shift_Del	NA	*P2354Lfs30**	0.22
COAD	chr12	49046369	Nonsense_Mutation	NA	Q1492*	0.56
COAD	chr12	49037400	Missense_Mutation	rs751075517	G3319D	0.31
COAD	chr12	49024703	Silent	NA	P5309P	0.5
COAD	chr12	49032848	Nonsense_Mutation	novel	Q3953*	0.26
COAD	chr12	49040709	Frame_Shift_Del	NA	*P2354Lfs30**	0.16
COAD	chr12	49040709	Frame_Shift_Del	NA	*P2354Lfs30**	0.29
COAD	chr12	49038441	Missense_Mutation	NA	E2972G	0.2
COAD	chr12	49031447	Missense_Mutation	rs199797812	R4420W	0.5
COAD	chr12	49043774	Missense_Mutation	NA	F1776L	0.2
COAD	chr12	49031492	Nonsense_Mutation	novel	Q4405*	0.08
COAD	chr12	49033483	In_Frame_Del	rs765688554	Q3744_Q3745del	0.46
COAD	chr12	49024941	Missense_Mutation	NA	W5264R	0.05
COAD	chr12	49040709	Frame_Shift_Del	NA	*P2354Lfs30**	0.07
COAD	chr12	49030394	Frame_Shift_Ins	NA	*T4629Hfs18**	0.31
COAD	chr12	49039519	Frame_Shift_Del	novel	*P2716Lfs17**	0.24
COAD	chr12	49031830	Missense_Mutation	NA	P4292L	0.14
COAD	chr12	49031962	Missense_Mutation	NA	T4248I	0.49
COAD	chr12	49052261	Silent	novel	L474L	0.07
COAD	chr12	49044867	Missense_Mutation	rs375118713	R1614W	0.24
COAD	chr12	49050981	Missense_Mutation	novel	S901Y	0.26
COAD	chr12	49043758	Silent	NA	L1782L	0.11
COAD	chr12	49050595	Frame_Shift_Del	NA	*P998Lfs2**	0.39
COAD	chr12	49038990	Splice_Site	NA	X2789_splice	0.4
COAD	chr12	49049884	Frame_Shift_Del	NA	*G1235Vfs95**	0.43
COAD	chr12	49026421	Missense_Mutation	NA	G5182D	0.12
COAD	chr12	49050594	Frame_Shift_Ins	novel	*M999Yfs69**	0.2
COAD	chr12	49052054	Silent	novel	S543S	0.34
COAD	chr12	49053623	Missense_Mutation	novel	V231G	0.2
COAD	chr12	49022633	Missense_Mutation	rs398123734	R5432Q	0.25
COAD	chr12	49038147	Missense_Mutation	NA	L3070P	0.13
COAD	chr12	49046139	Missense_Mutation	NA	E1540G	0.44
COAD	chr12	49026421	Frame_Shift_Del	NA	*G5182Afs61**	0.57
COAD	chr12	49040935	Frame_Shift_Ins	NA	*G2279Wfs20**	0.45
COAD	chr12	49042610	Missense_Mutation	NA	P1940T	0.43
COAD	chr12	49040709	Frame_Shift_Del	NA	*P2354Lfs30**	0.22
COAD	chr12	49033484	Nonsense_Mutation	novel	Q3741*	0.31
COAD	chr12	49041131	Silent	rs200895959	G2213G	0.25
COAD	chr12	49054097	Missense_Mutation	rs771025627	R185H	0.34
COAD	chr12	49046347	Missense_Mutation	NA	G1499V	0.14
COAD	chr12	49034900	Missense_Mutation	NA	P3423T	0.45
COAD	chr12	49038637	Frame_Shift_Del	NA	*Y2907Tfs3**	0.26
COAD	chr12	49046157	Missense_Mutation	NA	C1534Y	0.6
COAD	chr12	49046258	Splice_Site	NA	X1528_splice	0.15
COAD	chr12	49050154	Missense_Mutation	NA	A1145D	0.35
COAD	chr12	49053990	Frame_Shift_Del	NA	*A221Lfs40**	0.08
COAD	chr12	49027088	Nonsense_Mutation	NA	R4960*	0.13
COAD	chr12	49046150	Silent	rs751508761	S1536S	0.23
COAD	chr12	49051149	Frame_Shift_Ins	rs767415197	*R845Pfs3**	0.16
COAD	chr12	49041191	Silent	rs556666267	P2193P	0.42
COAD	chr12	49054983	Silent	novel	S31S	0.3
COAD	chr12	49030395	Frame_Shift_Del	NA	*T4629Pfs11**	0.27
COAD	chr12	49046632	Frame_Shift_Del	NA	*K1466Rfs40**	0.31
COAD	chr12	49032239	Frame_Shift_Del	novel	*Q4156Nfs5**	0.15
COAD	chr12	49042188	Nonsense_Mutation	NA	Q2004*	0.39
COAD	chr12	49024916	Missense_Mutation	NA	A5272V	0.11
COAD	chr12	49050603	Silent	NA	P995P	0.12
COAD	chr12	49033123	In_Frame_Del	rs777796038	Q3863del	0.33
COAD	chr12	49051890	Missense_Mutation	rs377761041	R598H	0.27
COAD	chr12	49031727	Frame_Shift_Del	NA	*S4327Afs57**	0.44
COAD	chr12	49039481	Missense_Mutation	novel	A2728V	0.18
COAD	chr12	49040295	Missense_Mutation	NA	G2492V	0.17
COAD	chr12	49026543	Silent	NA	P5141P	0.36
COAD	chr12	49031254	Missense_Mutation	NA	R4484Q	0.41
COAD	chr12	49043871	Silent	NA	L1772L	0.29
COAD	chr12	49031766	Silent	NA	S4313S	0.1
COAD	chr12	49033896	Silent	NA	Q3603Q	0.08
COAD	chr12	49040709	Frame_Shift_Del	NA	*P2354Lfs30**	0.12
COAD	chr12	49034153	Frame_Shift_Ins	rs763440821	*A3552Sfs4**	0.51
COAD	chr12	49038051	Frame_Shift_Del	NA	*P3102Lfs17**	0.26
COAD	chr12	49038488	Silent	rs758061875	T2956T	0.26
COAD	chr12	49039817	Silent	NA	G2651G	0.25
COAD	chr12	49052090	Silent	NA	A531A	0.42
COAD	chr12	49038091	Frame_Shift_Del	NA	*V3089Wfs30**	0.12
COAD	chr12	49052286	Missense_Mutation	NA	R466H	0.38
COAD	chr12	49051026	Frame_Shift_Del	NA	*P886Lfs44**	0.57
COAD	chr12	49051743	Frame_Shift_Del	NA	*P647Hfs283**	0.24
COAD	chr12	49022331	Missense_Mutation	NA	R5454Q	0.21
COAD	chr12	49027102	Missense_Mutation	NA	S4955F	0.28
COAD	chr12	49052620	Missense_Mutation	novel	V401A	0.06
COAD	chr12	49022101	Missense_Mutation	novel	F5488S	0.16
COAD	chr12	49031290	Missense_Mutation	rs768387349	V4472A	0.18
COAD	chr12	49044500	Silent	rs143063879	C1662C	0.09
COAD	chr12	49024861	Silent	rs776989239	G5290G	0.32
COAD	chr12	49037566	Missense_Mutation	NA	Q3264K	0.17
COAD	chr12	49038127	Missense_Mutation	NA	N3077D	0.28
COAD	chr12	49044259	Missense_Mutation	rs587778457	T1710M	0.16
COAD	chr12	49021850	Missense_Mutation	NA	D5515G	0.27
COAD	chr12	49032825	Silent	novel	Q3960Q	0.08
COAD	chr12	49040307	Missense_Mutation	rs779629382	S2488L	0.23
COAD	chr12	49022700	Missense_Mutation	novel	G5410W	0.34
COAD	chr12	49026740	Frame_Shift_Del	novel	*A5076Hfs2**	0.12
COAD	chr12	49033896	Silent	NA	Q3603Q	0.16
COAD	chr12	49040177	Frame_Shift_Del	NA	*S2532Lfs11**	0.24
COAD	chr12	49033884	Silent	NA	Q3607Q	0.25
COAD	chr12	49038732	Missense_Mutation	NA	A2875V	0.32
COAD	chr12	49044766	Silent	rs748740454	T1647T	0.13
COAD	chr12	49049884	Frame_Shift_Del	NA	*G1235Vfs95**	0.1
COAD	chr12	49032760	Missense_Mutation	rs760983900	R3982Q	0.24
COAD	chr12	49042574	Missense_Mutation	NA	F1952L	0.15
COAD	chr12	49030356	Silent	rs753898265	G4641G	0.29
COAD	chr12	49052114	Silent	rs568575580	P523P	0.36
COAD	chr12	49046298	In_Frame_Del	novel	H1511_V1515del	0.07
COAD	chr12	49040438	Silent	NA	F2444F	0.68
COAD	chr12	49033762	Missense_Mutation	rs758858726	P3648L	0.18
COAD	chr12	49040837	Silent	NA	S2311S	0.6
COAD	chr12	49037654	Silent	NA	D3234D	0.27
COAD	chr12	49039939	Missense_Mutation	rs572359740	R2611C	0.07
COAD	chr12	49044864	Nonsense_Mutation	NA	R1615*	0.52
DLBC	chr12	49022137	Missense_Mutation	novel	S5476Y	0.33
DLBC	chr12	49022139	Missense_Mutation	novel	H5475Q	0.35
DLBC	chr12	49048032	Frame_Shift_Ins	rs756471180	*A1390Gfs42**	0.42
DLBC	chr12	49041250	Nonsense_Mutation	NA	Q2174*	0.36
DLBC	chr12	49027906	Missense_Mutation	novel	G4847V	0.36
DLBC	chr12	49033896	Silent	NA	Q3603Q	0.07
DLBC	chr12	49033541	Nonsense_Mutation	novel	Q3722*	0.68
DLBC	chr12	49042158	Nonsense_Mutation	NA	Q2014*	0.24
DLBC	chr12	49042593	Frame_Shift_Ins	novel	*G1946Rfs11**	0.2
DLBC	chr12	49026641	Missense_Mutation	novel	C5109R	0.26
DLBC	chr12	49034409	Splice_Site	novel	X3503_splice	0.61
DLBC	chr12	49032602	Frame_Shift_Del	novel	*S4034Qfs15**	0.63
DLBC	chr12	49051263	Frame_Shift_Ins	novel	*S807Ffs5**	0.69
DLBC	chr12	49051265	Silent	novel	L806L	0.7
DLBC	chr12	49038664	Nonsense_Mutation	novel	Q2898*	0.28
DLBC	chr12	49033319	Nonsense_Mutation	NA	Q3796*	0.17
ESCA	chr12	49033481	Nonsense_Mutation	novel	Q3742*	0.17
ESCA	chr12	49026430	Missense_Mutation	rs267607237	R5179H	0.31
ESCA	chr12	49026594	Frame_Shift_Ins	novel	*M5124Ifs14**	0.12
ESCA	chr12	49033133	Nonsense_Mutation	novel	Q3858*	0.5
ESCA	chr12	49031273	Missense_Mutation	rs562043836	R4478W	0.17
ESCA	chr12	49038067	Missense_Mutation	novel	E3097K	0.05
ESCA	chr12	49034135	Nonsense_Mutation	novel	E3558*	0.22
ESCA	chr12	49049684	Frame_Shift_Del	novel	*K1301Gfs22**	0.38
ESCA	chr12	49037474	Frame_Shift_Del	novel	*P3291Hfs6**	0.43
ESCA	chr12	49037862	Frame_Shift_Ins	novel	*D3165Gfs11**	0.47
ESCA	chr12	49031720	Nonsense_Mutation	novel	Q4329*	0.25
ESCA	chr12	49034894	Frame_Shift_Ins	novel	*A3425Cfs43**	0.32
ESCA	chr12	49041917	Splice_Region	novel	L2061L	0.44
ESCA	chr12	49026640	Missense_Mutation	NA	C5109F	0.42
ESCA	chr12	49048071	Splice_Site	novel	X1378_splice	0.44
ESCA	chr12	49029118	Nonsense_Mutation	novel	Q4732*	0.19
ESCA	chr12	49029119	Missense_Mutation	novel	E4731D	0.19
ESCA	chr12	49037437	Missense_Mutation	novel	A3307T	0.32
ESCA	chr12	49051890	Missense_Mutation	rs377761041	R598H	0.12
ESCA	chr12	49039735	Nonsense_Mutation	novel	K2679*	0.15
ESCA	chr12	49022769	Nonsense_Mutation	NA	Q5387*	0.31
ESCA	chr12	49052923	Silent	novel	V368V	0.18
ESCA	chr12	49038626	Frame_Shift_Del	NA	*S2910Rfs32**	0.26
ESCA	chr12	49051367	Silent	novel	P772P	0.55
ESCA	chr12	49039761	Missense_Mutation	novel	S2670F	0.36
ESCA	chr12	49042193	Missense_Mutation	novel	S2002I	0.53
ESCA	chr12	49038247	Frame_Shift_Del	novel	*H3037Tfs34**	0.36
ESCA	chr12	49032800	Nonsense_Mutation	NA	Q3969*	0.31
ESCA	chr12	49039497	Missense_Mutation	novel	E2723K	0.37
ESCA	chr12	49050790	Frame_Shift_Del	novel	*D933Vfs25**	0.23
GBM	chr12	49049869	Frame_Shift_Ins	novel	*M1240Tfs11**	0.34
GBM	chr12	49054080	Missense_Mutation	NA	R191W	0.3
GBM	chr12	49041498	Missense_Mutation	novel	G2091A	0.05
GBM	chr12	49054539	Missense_Mutation	NA	G130E	0.54
GBM	chr12	49028883	Missense_Mutation	novel	K4776T	0.07
GBM	chr12	49038648	Missense_Mutation	novel	R2903I	0.28
GBM	chr12	49040415	Missense_Mutation	novel	R2452H	0.46
GBM	chr12	49040948	Silent	novel	S2274S	0.1
GBM	chr12	49049913	Silent	novel	P1225P	0.27
GBM	chr12	49026974	Missense_Mutation	novel	K4998E	0.11
GBM	chr12	49038433	Missense_Mutation	rs544530436	R2975C	0.39
GBM	chr12	49026756	Nonsense_Mutation	NA	Y5070*	0.32
GBM	chr12	49046415	Silent	novel	S1476S	0.14
GBM	chr12	49034595	Missense_Mutation	novel	A3476G	0.08
GBM	chr12	49038443	Silent	novel	T2971T	0.35
GBM	chr12	49042740	Splice_Site	rs766123066	X1928_splice	0.17
HNSC	chr12	49042819	Nonsense_Mutation	novel	E1902*	0.48
HNSC	chr12	49054752	Splice_Site	NA	X59_splice	0.6
HNSC	chr12	49040220	Frame_Shift_Del	novel	*S2512Ifs26**	0.55
HNSC	chr12	49033586	Nonsense_Mutation	NA	R3707*	0.09
HNSC	chr12	49040152	Nonsense_Mutation	novel	Q2540*	0.38
HNSC	chr12	49051401	Frame_Shift_Del	novel	*L761Hfs169**	0.17
HNSC	chr12	49053602	Frame_Shift_Del	novel	*L238Cfs23**	0.69
HNSC	chr12	49046631	Frame_Shift_Ins	NA	*K1466Qfs25**	0.1
HNSC	chr12	49029417	Nonsense_Mutation	novel	Q4687*	0.5
HNSC	chr12	49054337	Silent	novel	V160V	0.37
HNSC	chr12	49038091	Frame_Shift_Del	NA	*V3089Wfs30**	0.48
HNSC	chr12	49021841	Missense_Mutation	novel	D5518G	0.19
HNSC	chr12	49031255	Nonsense_Mutation	rs587783690	R4484*	0.43
HNSC	chr12	49038440	Silent	novel	E2972E	0.23
HNSC	chr12	49046647	Frame_Shift_Ins	novel	*L1461Tfs30**	0.19
HNSC	chr12	49040524	Nonsense_Mutation	NA	Q2416*	0.11
HNSC	chr12	49037891	Frame_Shift_Ins	novel	*P3156Afs20**	0.6
HNSC	chr12	49044402	Splice_Site	novel	X1695_splice	0.35
HNSC	chr12	49049920	Nonsense_Mutation	novel	S1223*	0.39
HNSC	chr12	49044812	Nonsense_Mutation	NA	S1632*	0.2
HNSC	chr12	49054910	Nonsense_Mutation	novel	Q56*	0.21
HNSC	chr12	49026781	Missense_Mutation	novel	C5062F	0.18
HNSC	chr12	49051723	Frame_Shift_Del	novel	*S654Pfs276**	0.42
HNSC	chr12	49024702	Missense_Mutation	novel	G5310R	0.44
HNSC	chr12	49048709	Nonsense_Mutation	NA	Q1361*	0.42
HNSC	chr12	49040761	Nonsense_Mutation	novel	Q2337*	0.3
HNSC	chr12	49051343	Nonsense_Mutation	novel	C780*	0.41
HNSC	chr12	49022633	Missense_Mutation	rs398123734	R5432Q	0.26
HNSC	chr12	49046375	Nonsense_Mutation	novel	E1490*	0.17
HNSC	chr12	49026401	Missense_Mutation	NA	G5189R	0.19
HNSC	chr12	49042200	Nonsense_Mutation	NA	Q2000*	0.53
HNSC	chr12	49022838	Missense_Mutation	novel	Y5364N	0.47
HNSC	chr12	49026889	Missense_Mutation	NA	P5026L	0.41
HNSC	chr12	49039294	Missense_Mutation	novel	S2765F	0.38
HNSC	chr12	49026325	Missense_Mutation	rs398123729	R5214H	0.42
HNSC	chr12	49026626	Missense_Mutation	NA	H5114Y	0.28
HNSC	chr12	49051542	Missense_Mutation	rs747636808	S714L	0.16
HNSC	chr12	49026764	Frame_Shift_Del	novel	*C5062Rfs10**	0.18
HNSC	chr12	49040993	Missense_Mutation	novel	E2259D	0.06
HNSC	chr12	49022063	Nonsense_Mutation	NA	R5501*	0.26
HNSC	chr12	49034667	Splice_Site	novel	X3452_splice	0.21
HNSC	chr12	49044481	Missense_Mutation	NA	P1669S	0.18
HNSC	chr12	49033475	Nonsense_Mutation	novel	Q3744*	0.22
HNSC	chr12	49026266	Missense_Mutation	novel	E5234K	0.27
HNSC	chr12	49026888	Frame_Shift_Ins	novel	*R5027Tfs12**	0.2
HNSC	chr12	49050190	Nonsense_Mutation	novel	S1133*	0.29
HNSC	chr12	49034581	Splice_Site	rs749356633	X3480_splice	0.33
HNSC	chr12	49050924	Missense_Mutation	novel	S920C	0.38
HNSC	chr12	49053596	Missense_Mutation	novel	D240G	0.43
HNSC	chr12	49041117	Frame_Shift_Del	novel	*P2218Lfs46**	0.22
HNSC	chr12	49049834	Nonsense_Mutation	rs727503987	R1252*	0.27
HNSC	chr12	49026845	Missense_Mutation	novel	G5041R	0.26
HNSC	chr12	49028913	Missense_Mutation	novel	P4766L	0.36
HNSC	chr12	49031932	Frame_Shift_Del	novel	*G4255Lfs75**	0.17
HNSC	chr12	49038661	Missense_Mutation	rs587778472	G2899S	0.37
HNSC	chr12	49054013	Missense_Mutation	novel	L213P	0.18
HNSC	chr12	49039605	Nonsense_Mutation	NA	R2687*	0.34
HNSC	chr12	49049834	Nonsense_Mutation	rs727503987	R1252*	0.21
HNSC	chr12	49044242	Missense_Mutation	novel	A1716S	0.28
HNSC	chr12	49053531	Missense_Mutation	NA	A262T	0.29
HNSC	chr12	49052916	Missense_Mutation	NA	R371G	0.25
HNSC	chr12	49048030	Missense_Mutation	novel	E1391K	0.38
HNSC	chr12	49034436	Missense_Mutation	rs746854405	P3494L	0.29
HNSC	chr12	49041992	Splice_Site	novel	X2037_splice	0.84
HNSC	chr12	49044762	Nonsense_Mutation	NA	E1649*	0.25
HNSC	chr12	49050486	Frame_Shift_Del	novel	*L1032Pfs33**	0.25
HNSC	chr12	49039497	Nonsense_Mutation	novel	E2723*	0.11
HNSC	chr12	49040632	Nonsense_Mutation	NA	Q2380*	0.18
HNSC	chr12	49050484	Frame_Shift_Ins	novel	*Q1035Pfs33**	0.37
HNSC	chr12	49030322	Nonsense_Mutation	novel	K4653*	0.33
HNSC	chr12	49053302	Frame_Shift_Ins	novel	*K287Vfs18**	0.37
HNSC	chr12	49039450	Frame_Shift_Del	novel	*F2739Lfs18**	0.26
HNSC	chr12	49051843	Nonsense_Mutation	novel	E614*	0.17
HNSC	chr12	49042637	Missense_Mutation	novel	P1931T	0.35
HNSC	chr12	49037880	Frame_Shift_Del	novel	*Q3158Pfs2**	0.25
HNSC	chr12	49051723	Frame_Shift_Del	novel	*E649Pfs276**	0.23
HNSC	chr12	49044864	Nonsense_Mutation	NA	R1615*	0.22
HNSC	chr12	49042181	Nonsense_Mutation	novel	W2006*	0.79
HNSC	chr12	49040542	Nonsense_Mutation	NA	R2410*	0.18
HNSC	chr12	49040926	Frame_Shift_Del	novel	*R2282Gfs4**	0.15
HNSC	chr12	49049857	Frame_Shift_Ins	novel	*V1244Gfs6**	0.24
HNSC	chr12	49040322	Missense_Mutation	novel	S2483C	0.09
HNSC	chr12	49040117	Frame_Shift_Del	novel	*K2548Tfs103**	0.15
HNSC	chr12	49044966	Splice_Site	novel	X1581_splice	0.08
HNSC	chr12	49026491	Missense_Mutation	novel	R5159W	0.34
HNSC	chr12	49050197	Missense_Mutation	novel	P1131A	0.4
HNSC	chr12	49042560	Splice_Site	novel	X1956_splice	0.46
HNSC	chr12	49053239	Nonsense_Mutation	novel	E308*	0.23
HNSC	chr12	49038091	Frame_Shift_Del	NA	*V3089Wfs30**	0.53
HNSC	chr12	49050116	Nonsense_Mutation	NA	E1158*	0.37
HNSC	chr12	49038199	Frame_Shift_Ins	novel	*T3053Yfs2**	0.34
KICH	chr12	49038466	Missense_Mutation	novel	V2964F	0.28
KICH	chr12	49042607	Missense_Mutation	rs372271746	M1941V	0.44
KIRC	chr12	49053529	Silent	rs368315432	A262A	0.2
KIRC	chr12	49053530	Missense_Mutation	NA	A262D	0.2
KIRC	chr12	49049964	Silent	rs755572302	I1208I	0.24
KIRC	chr12	49049168	Missense_Mutation	novel	H1319Q	0.21
KIRC	chr12	49027089	Silent	NA	A4959A	0.16
KIRC	chr12	49031256	Silent	rs376096667	L4483L	0.38
KIRC	chr12	49046676	Missense_Mutation	NA	S1451C	0.27
KIRC	chr12	49049833	Missense_Mutation	rs753048826	R1252L	0.18
KIRC	chr12	49033381	Missense_Mutation	NA	G3775D	0.33
KIRC	chr12	49042804	Missense_Mutation	NA	L1907V	0.22
KIRC	chr12	49050555	Silent	rs373881433	P1011P	0.21
KIRC	chr12	49028942	Missense_Mutation	NA	K4756N	0.42
KIRC	chr12	49038320	In_Frame_Ins	novel	A3010_L3012dup	0.24
KIRP	chr12	49040427	Frame_Shift_Del	novel	*D2448Afs37**	0.39
KIRP	chr12	49043896	Missense_Mutation	NA	L1764P	0.32
KIRP	chr12	49034205	Silent	novel	V3534V	0.42
KIRP	chr12	49039597	Silent	NA	L2689L	0.33
KIRP	chr12	49044239	Missense_Mutation	novel	Q1717K	0.43
KIRP	chr12	49041415	Frame_Shift_Ins	rs755159728	*A2119Rfs36**	0.53
KIRP	chr12	49052292	Missense_Mutation	NA	A464V	0.25
KIRP	chr12	49038205	Missense_Mutation	NA	A3051P	0.23
KIRP	chr12	49032056	Nonsense_Mutation	novel	Q4217*	0.39
KIRP	chr12	49038378	Missense_Mutation	NA	L2993R	0.29
KIRP	chr12	49051847	Silent	novel	P612P	0.3
KIRP	chr12	49049774	Frame_Shift_Del	novel	*L1272Vfs13**	0.16
KIRP	chr12	49040614	Missense_Mutation	novel	R2386G	0.36
KIRP	chr12	49038047	Silent	NA	A3103A	0.38
KIRP	chr12	49040452	Missense_Mutation	rs375114492	V2440I	0.33
KIRP	chr12	49022351	Missense_Mutation	NA	N5447K	0.56
KIRP	chr12	49043162	Missense_Mutation	NA	A1853V	0.08
LAML	chr12	49022063	Nonsense_Mutation	NA	R5501*	0.03
LAML	chr12	49031584	Missense_Mutation	NA	L4374Q	0.63
LAML	chr12	49040020	Missense_Mutation	novel	T2584P	0.36
LAML	chr12	49030303	Missense_Mutation	novel	R4659Q	0.63
LGG	chr12	49026938	Missense_Mutation	novel	A5010T	0.33
LGG	chr12	49024928	Missense_Mutation	NA	I5268T	0.64
LGG	chr12	49048065	Frame_Shift_Del	rs398123744	*M1379Vfs52**	0.14
LGG	chr12	49022350	Nonsense_Mutation	NA	R5448*	0.45
LGG	chr12	49029133	Missense_Mutation	NA	S4727P	0.19
LGG	chr12	49051419	Missense_Mutation	rs776110112	R755Q	0.35
LGG	chr12	49052138	Silent	NA	L515L	0.36
LGG	chr12	49031287	Missense_Mutation	NA	Q4473P	0.2
LGG	chr12	49037430	Missense_Mutation	NA	S3309F	0.67
LGG	chr12	49043915	Missense_Mutation	novel	G1758R	0.45
LGG	chr12	49050412	Missense_Mutation	novel	G1059E	0.33
LGG	chr12	49055279	Missense_Mutation	novel	A16T	0.32
LGG	chr12	49052607	Silent	NA	Q405Q	0.57
LGG	chr12	49037294	Silent	novel	G3354G	0.07
LIHC	chr12	49034167	Missense_Mutation	rs775632051	R3547H	0.5
LIHC	chr12	49040053	Missense_Mutation	novel	G2573S	0.15
LIHC	chr12	49022279	Splice_Site	rs794727752	X5471_splice	0.21
LIHC	chr12	49033636	Missense_Mutation	novel	G3690V	0.26
LIHC	chr12	49033637	Missense_Mutation	novel	G3690R	0.26
LIHC	chr12	49037559	Missense_Mutation	NA	L3266H	0.19
LIHC	chr12	49039559	Missense_Mutation	novel	Q2702L	0.45
LIHC	chr12	49037395	Nonsense_Mutation	rs793888512	R3321*	0.19
LIHC	chr12	49026260	Missense_Mutation	NA	N5236H	0.47
LIHC	chr12	49052062	Missense_Mutation	novel	E541K	0.19
LIHC	chr12	49046062	Splice_Region	novel		0.43
LIHC	chr12	49052239	Missense_Mutation	novel	A482T	0.33
LIHC	chr12	49049816	Missense_Mutation	NA	R1258W	0.42
LIHC	chr12	49031453	Frame_Shift_Del	novel	*E4418Nfs14**	0.35
LIHC	chr12	49038072	Missense_Mutation	NA	G3095D	0.42
LIHC	chr12	49022743	Missense_Mutation	novel	W5395C	0.46
LIHC	chr12	49038240	Missense_Mutation	NA	D3039G	0.44
LIHC	chr12	49033010	Nonsense_Mutation	novel	Q3899*	0.45
LIHC	chr12	49033896	Silent	NA	Q3603Q	0.09
LIHC	chr12	49046776	Missense_Mutation	novel	M1417I	0.38
LIHC	chr12	49039307	Silent	NA	L2761L	0.51
LIHC	chr12	49033896	Silent	NA	Q3603Q	0.14
LIHC	chr12	49055310	Frame_Shift_Del	novel	*S3Tfs4**	0.34
LIHC	chr12	49033896	Silent	NA	Q3603Q	0.09
LIHC	chr12	49033311	Silent	novel	P3798P	0.08
LIHC	chr12	49050099	Silent	NA	V1163V	0.15
LIHC	chr12	49031279	Frame_Shift_Del	novel	*T4476Lfs43**	0.51
LUAD	chr12	49053531	Missense_Mutation	NA	A262S	0.33
LUAD	chr12	49022647	Missense_Mutation	NA	I5427M	0.04
LUAD	chr12	49039788	Missense_Mutation	novel	L2661H	0.17
LUAD	chr12	49041332	Silent	novel	P2146P	0.2
LUAD	chr12	49051021	Missense_Mutation	NA	E888K	0.05
LUAD	chr12	49044845	Missense_Mutation	novel	P1621L	0.1
LUAD	chr12	49031749	Missense_Mutation	novel	R4319I	0.57
LUAD	chr12	49051681	Nonsense_Mutation	NA	E668*	0.42
LUAD	chr12	49051682	Missense_Mutation	novel	E667D	0.4
LUAD	chr12	49044239	Nonsense_Mutation	novel	Q1717*	0.17
LUAD	chr12	49046425	Splice_Site	NA	X1473_splice	0.06
LUAD	chr12	49040709	Frame_Shift_Del	NA	*P2354Lfs30**	0.08
LUAD	chr12	49038614	Missense_Mutation	NA	H2914Q	0.36
LUAD	chr12	49051450	Missense_Mutation	NA	P745S	0.28
LUAD	chr12	49040902	Frame_Shift_Del	novel	*E2290Kfs32**	0.41
LUAD	chr12	49028876	Missense_Mutation	novel	K4778N	0.16
LUAD	chr12	49051157	Silent	novel	L842L	0.13
LUAD	chr12	49048011	Missense_Mutation	novel	C1397Y	0.07
LUAD	chr12	49032113	Nonsense_Mutation	rs587783685	R4198*	0.24
LUAD	chr12	49040944	Missense_Mutation	rs368486128	P2276S	0.42
LUAD	chr12	49028901	Missense_Mutation	NA	P4770L	0.28
LUAD	chr12	49044234	Silent	NA	A1718A	0.33
LUAD	chr12	49031244	Silent	novel	I4487I	0.06
LUAD	chr12	49052390	Missense_Mutation	novel	E431D	0.22
LUAD	chr12	49026341	Missense_Mutation	novel	G5209C	0.34
LUAD	chr12	49048731	Silent	NA	E1353E	0.11
LUAD	chr12	49043384	Nonsense_Mutation	NA	E1838*	0.12
LUAD	chr12	49044248	Missense_Mutation	NA	P1714S	0.33
LUAD	chr12	49046159	Silent	NA	G1533G	0.2
LUAD	chr12	49039968	Missense_Mutation	NA	T2601I	0.39
LUAD	chr12	49034226	Silent	novel	V3527V	0.18
LUAD	chr12	49051357	Nonsense_Mutation	NA	E776*	0.33
LUAD	chr12	49050776	Missense_Mutation	NA	P938A	0.36
LUAD	chr12	49052143	Missense_Mutation	NA	P514S	0.22
LUAD	chr12	49031704	Missense_Mutation	novel	A4334D	0.33
LUAD	chr12	49026984	Silent	novel	L4994L	0.12
LUAD	chr12	49051078	Missense_Mutation	novel	E869K	0.35
LUAD	chr12	49052159	Silent	novel	E508E	0.35
LUAD	chr12	49040777	Silent	NA	L2331L	0.45
LUAD	chr12	49026411	Silent	rs575965702	F5185F	0.19
LUAD	chr12	49042593	Silent	novel	P1945P	0.17
LUAD	chr12	49053534	Missense_Mutation	novel	T261S	0.33
LUAD	chr12	49050558	Silent	NA	G1010G	0.48
LUAD	chr12	49053604	Silent	rs192397485	E237E	0.56
LUAD	chr12	49028855	Missense_Mutation	novel	M4785I	0.4
LUAD	chr12	49026212	Missense_Mutation	NA	D5252Y	0.13
LUAD	chr12	49044474	Missense_Mutation	novel	S1671I	0.15
LUAD	chr12	49052309	Silent	novel	T458T	0.13
LUAD	chr12	49051504	Missense_Mutation	NA	P727S	0.35
LUAD	chr12	49049714	Missense_Mutation	rs762841102	R1292C	0.06
LUAD	chr12	49050261	Silent	NA	A1109A	0.17
LUAD	chr12	49026488	Missense_Mutation	NA	D5160H	0.33
LUAD	chr12	49038460	Missense_Mutation	NA	R2966W	0.38
LUAD	chr12	49042591	Missense_Mutation	NA	G1946A	0.21
LUSC	chr12	49047978	Missense_Mutation	NA	C1408F	0.36
LUSC	chr12	49027323	Splice_Site	novel	X4882_splice	0.6
LUSC	chr12	49029237	Splice_Site	novel	X4692_splice	0.27
LUSC	chr12	49050574	Missense_Mutation	rs371286331	P1005L	0.19
LUSC	chr12	49032615	Frame_Shift_Del	novel	*Q4026Pfs9**	0.11
LUSC	chr12	49046756	Missense_Mutation	novel	C1424S	0.11
LUSC	chr12	49032079	Frame_Shift_Del	novel	*P4209Tfs124**	0.18
LUSC	chr12	49031890	Missense_Mutation	rs763518333	G4272D	0.44
LUSC	chr12	49050595	Frame_Shift_Del	NA	*P998Lfs2**	0.19
LUSC	chr12	49040835	Nonsense_Mutation	NA	S2312*	0.28
LUSC	chr12	49038176	Silent	novel	G3060G	0.11
LUSC	chr12	49039976	Frame_Shift_Del	novel	*S2590Wfs56**	0.32
LUSC	chr12	49038132	Missense_Mutation	NA	S3075L	0.31
LUSC	chr12	49051554	Frame_Shift_Ins	novel	*P710Hfs21**	0.42
LUSC	chr12	49037744	Silent	NA	P3204P	0.39
LUSC	chr12	49034848	Frame_Shift_Del	novel	*A3440Vfs11**	0.26
LUSC	chr12	49040825	Missense_Mutation	rs764686162	H2315Q	0.16
LUSC	chr12	49033514	Missense_Mutation	novel	A3731S	0.29
LUSC	chr12	49041474	Missense_Mutation	novel	R2099L	0.36
LUSC	chr12	49026421	Frame_Shift_Del	NA	*G5182Afs61**	0.1
LUSC	chr12	49050437	Missense_Mutation	NA	V1051I	0.23
LUSC	chr12	49052023	Silent	novel	L554L	0.09
LUSC	chr12	49050979	Nonsense_Mutation	novel	E902*	0.12
LUSC	chr12	49038108	Frame_Shift_Del	novel	*R3082Gfs14**	0.22
LUSC	chr12	49049886	Silent	novel	G1234G	0.4
LUSC	chr12	49039604	Frame_Shift_Del	novel	*R2687Qfs4**	0.4
LUSC	chr12	49038675	Missense_Mutation	rs771221036	P2894L	0.38
LUSC	chr12	49046089	Nonsense_Mutation	novel	Q1557*	0.5
LUSC	chr12	49051360	Nonsense_Mutation	novel	E775*	0.23
LUSC	chr12	49050078	Frame_Shift_Del	novel	*E1171Nfs41**	0.35
LUSC	chr12	49022706	Missense_Mutation	novel	G5408S	0.28
LUSC	chr12	49050788	Frame_Shift_Ins	novel	*P934Nfs37**	0.06
LUSC	chr12	49026215	Nonsense_Mutation	NA	E5251*	0.29
LUSC	chr12	49048039	Missense_Mutation	rs767110613	R1388W	0.13
LUSC	chr12	49037359	Nonsense_Mutation	NA	Q3333*	0.43
LUSC	chr12	49040865	Frame_Shift_Del	novel	*P2302Qfs20**	0.25
LUSC	chr12	49050122	Frame_Shift_Del	novel	*D1156Pfs27**	0.43
LUSC	chr12	49050123	Nonsense_Mutation	novel	L1155_D1156ins*	0.43
LUSC	chr12	49041483	Missense_Mutation	novel	K2096M	0.21
LUSC	chr12	49040058	Missense_Mutation	rs779982818	T2571I	0.06
LUSC	chr12	49027155	Frame_Shift_Del	novel	*T4938Pfs57**	0.4
LUSC	chr12	49043156	Missense_Mutation	novel	P1855L	0.39
LUSC	chr12	49051554	Missense_Mutation	rs758912919	P710R	0.46
LUSC	chr12	49044861	Nonsense_Mutation	novel	G1616*	0.32
LUSC	chr12	49052374	Nonsense_Mutation	novel	E437*	0.34
LUSC	chr12	49040179	Missense_Mutation	rs371432516	P2531S	0.4
LUSC	chr12	49031694	Nonsense_Mutation	novel	*P4338Afs4**	0.18
LUSC	chr12	49052711	Splice_Site	NA	X371_splice	0.35
LUSC	chr12	49043731	Missense_Mutation	novel	A1791P	0.29
LUSC	chr12	49041120	Missense_Mutation	NA	R2217H	0.53
LUSC	chr12	49034129	Missense_Mutation	NA	D3560N	0.24
LUSC	chr12	49021683	3'UTR	novel		0.26
LUSC	chr12	49026817	Missense_Mutation	NA	L5050R	0.08
LUSC	chr12	49034129	Missense_Mutation	NA	D3560N	0.13
LUSC	chr12	49041076	Missense_Mutation	NA	G2232S	0.44
LUSC	chr12	49022042	Splice_Site	novel	X5507_splice	0.18
LUSC	chr12	49041238	Frame_Shift_Ins	novel	*G2178Wfs24**	0.37
LUSC	chr12	49031945	Frame_Shift_Del	novel	*Q4254Rfs24**	0.31
LUSC	chr12	49049988	Missense_Mutation	NA	I1200M	0.31
LUSC	chr12	49049167	Nonsense_Mutation	NA	G1320*	0.53
LUSC	chr12	49039917	In_Frame_Del	novel	S2614_P2618del	0.27
LUSC	chr12	49022599	Nonsense_Mutation	NA	Y5443*	0.29
LUSC	chr12	49051684	Missense_Mutation	novel	E667Q	0.19
LUSC	chr12	49026430	Missense_Mutation	NA	R5179L	0.19
LUSC	chr12	49048047	Missense_Mutation	NA	S1385I	0.22
LUSC	chr12	49037701	Frame_Shift_Del	novel	*A3219Lfs2**	0.73
LUSC	chr12	49039441	Frame_Shift_Del	novel	*T2742Hfs15**	0.27
LUSC	chr12	49052134	Nonsense_Mutation	novel	E517*	0.45
LUSC	chr12	49039360	Splice_Site	novel	X2744_splice	0.28
LUSC	chr12	49051048	Nonsense_Mutation	novel	E879*	0.43
LUSC	chr12	49051366	Frame_Shift_Del	novel	*Q773Sfs157**	0.33
LUSC	chr12	49040398	Nonsense_Mutation	NA	Q2458*	0.32
LUSC	chr12	49040332	Nonsense_Mutation	novel	K2480*	0.19
LUSC	chr12	49050922	Frame_Shift_Ins	novel	*G921Wfs48**	0.37
LUSC	chr12	49050887	Splice_Region	rs757768061	P932P	0.32
LUSC	chr12	49032011	Nonsense_Mutation	novel	Q4232*	0.22
LUSC	chr12	49037304	Missense_Mutation	novel	S3351Y	0.56
LUSC	chr12	49050337	Missense_Mutation	NA	P1084L	0.59
LUSC	chr12	49043883	Frame_Shift_Ins	novel	*A1770Cfs18**	0.43
LUSC	chr12	49050917	Silent	novel	E922E	0.23
LUSC	chr12	49042645	Frame_Shift_Del	novel	*G1928Vfs119**	0.52
LUSC	chr12	49037278	Nonsense_Mutation	NA	Q3360*	0.33
LUSC	chr12	49044435	Missense_Mutation	NA	S1684T	0.22
LUSC	chr12	49022633	Missense_Mutation	novel	R5432L	0.32
LUSC	chr12	49051657	Nonsense_Mutation	novel	E676*	0.32
LUSC	chr12	49051351	Missense_Mutation	NA	C778R	0.3
LUSC	chr12	49048660	Missense_Mutation	NA	Q1377R	0.38
LUSC	chr12	49027058	Nonsense_Mutation	NA	E4970*	0.5
LUSC	chr12	49030934	Missense_Mutation	novel	G4544W	0.52
LUSC	chr12	49049681	Splice_Site	NA	X1302_splice	0.38
LUSC	chr12	49048734	Frame_Shift_Del	novel	*K1350Rfs5**	0.29
LUSC	chr12	49048063	Missense_Mutation	novel	C1380G	0.36
LUSC	chr12	49037742	Missense_Mutation	NA	G3205V	0.38
LUSC	chr12	49037908	Frame_Shift_Del	novel	*G3151Afs4**	0.2
LUSC	chr12	49033493	Nonsense_Mutation	novel	Q3738*	0.52
LUSC	chr12	49040348	Silent	novel	P2474P	0.28
LUSC	chr12	49043963	Nonsense_Mutation	novel	E1742*	0.61
LUSC	chr12	49055276	Missense_Mutation	novel	A17T	0.64
LUSC	chr12	49032212	Nonsense_Mutation	novel	Q4165*	0.44
LUSC	chr12	49051343	Silent	rs530563702	C780C	0.43
LUSC	chr12	49041523	Nonsense_Mutation	novel	Q2083*	0.25
LUSC	chr12	49048041	Missense_Mutation	NA	G1387V	0.2
LUSC	chr12	49032085	Missense_Mutation	NA	K4207R	0.27
LUSC	chr12	49040593	Nonsense_Mutation	NA	E2393*	0.77
LUSC	chr12	49029123	Missense_Mutation	novel	W4730L	0.32
LUSC	chr12	49038271	Nonsense_Mutation	novel	E3029*	0.23
LUSC	chr12	49039468	Silent	novel	L2732L	0.38
LUSC	chr12	49042825	Missense_Mutation	novel	G1900C	0.21
LUSC	chr12	49028055	Silent	rs765477601	P4823P	0.15
LUSC	chr12	49052126	Silent	NA	P519P	0.22
LUSC	chr12	49041991	Splice_Site	novel	X2037_splice	0.27
LUSC	chr12	49052679	Frame_Shift_Del	NA	*T382Lfs20**	0.16
LUSC	chr12	49034667	Splice_Site	novel	X3452_splice	0.17
LUSC	chr12	49033667	Nonsense_Mutation	novel	Q3680*	0.47
LUSC	chr12	49033472	Nonsense_Mutation	NA	Q3745*	0.45
LUSC	chr12	49022043	Missense_Mutation	NA	E5507D	0.48
LUSC	chr12	49033577	Nonsense_Mutation	novel	G3710*	0.38
LUSC	chr12	49038091	Frame_Shift_Del	NA	*V3089Wfs30**	0.46
LUSC	chr12	49022621	Frame_Shift_Del	novel	*T5429Qfs22**	0.1
LUSC	chr12	49024666	Missense_Mutation	novel	G5322R	0.3
LUSC	chr12	49051306	Nonsense_Mutation	novel	E793*	0.49
LUSC	chr12	49040865	Frame_Shift_Del	novel	*P2302Qfs20**	0.33
LUSC	chr12	49046633	Missense_Mutation	novel	P1465R	0.29
LUSC	chr12	49049884	Frame_Shift_Del	NA	*G1235Vfs95**	0.39
LUSC	chr12	49037247	Frame_Shift_Ins	novel	*Q3370Pfs53**	0.32
LUSC	chr12	49041176	Frame_Shift_Del	NA	*Y2199Ifs65**	0.17
LUSC	chr12	49040152	Nonsense_Mutation	novel	Q2540*	0.18
LUSC	chr12	49026871	Missense_Mutation	novel	C5032F	0.33
LUSC	chr12	49032699	Silent	rs375116340	P4002P	0.32
LUSC	chr12	49046660	Missense_Mutation	novel	C1456F	0.52
LUSC	chr12	49031855	Nonsense_Mutation	NA	Q4284*	0.43
LUSC	chr12	49038552	Nonsense_Mutation	NA	S2935*	0.2
LUSC	chr12	49050270	Frame_Shift_Del	novel	*P1106Qfs8**	0.2
LUSC	chr12	49051681	Nonsense_Mutation	NA	E668*	0.13
LUSC	chr12	49031532	Silent	novel	Q4391Q	0.6
LUSC	chr12	49054401	Missense_Mutation	novel	H139L	0.36
LUSC	chr12	49038096	Missense_Mutation	NA	R3087L	0.45
LUSC	chr12	49040812	Nonsense_Mutation	novel	E2320*	0.22
LUSC	chr12	49040813	Silent	novel	L2319L	0.21
LUSC	chr12	49043667	Nonsense_Mutation	NA	S1812*	0.1
LUSC	chr12	49026862	Missense_Mutation	NA	C5035F	0.08
LUSC	chr12	49041274	Nonsense_Mutation	NA	Q2166*	0.33
LUSC	chr12	49040943	Frame_Shift_Del	novel	*P2276Hfs10**	0.11
LUSC	chr12	49026398	Nonsense_Mutation	novel	Q5190*	0.21
LUSC	chr12	49040844	Nonsense_Mutation	novel	S2309*	0.1
LUSC	chr12	49051743	Frame_Shift_Del	NA	*P647Hfs283**	0.22
LUSC	chr12	49052008	Missense_Mutation	novel	E559K	0.1
LUSC	chr12	49042780	Nonsense_Mutation	novel	E1915*	0.41
LUSC	chr12	49037299	Nonsense_Mutation	novel	Q3353*	0.14
LUSC	chr12	49038205	Missense_Mutation	novel	A3051S	0.21
LUSC	chr12	49038206	Silent	novel	L3050L	0.2
OV	chr12	49050505	Frame_Shift_Del	novel	*Q1023Sfs39**	0.1
OV	chr12	49026643	Missense_Mutation	novel	R5108H	0.04
OV	chr12	49026430	Missense_Mutation	rs267607237	R5179H	0.44
OV	chr12	49043414	Missense_Mutation	NA	D1828H	0.03
OV	chr12	49037272	Nonsense_Mutation	novel	G3362*	0.14
OV	chr12	49049931	Missense_Mutation	novel	S1219R	0.32
OV	chr12	49038278	Silent	NA	G3026G	0.31
OV	chr12	49049708	Missense_Mutation	novel	S1294A	0.36
OV	chr12	49033686	Silent	NA	L3673L	0.38
OV	chr12	49048063	Missense_Mutation	novel	C1380S	0.06
OV	chr12	49043870	Nonsense_Mutation	NA	Q1773*	0.24
OV	chr12	49022117	Missense_Mutation	novel	A5483S	0.05
OV	chr12	49028909	Silent	novel	G4767G	0.1
OV	chr12	49034168	Missense_Mutation	novel	R3547C	0.47
OV	chr12	49049709	Missense_Mutation	novel	S1293R	0.21
OV	chr12	49033875	Missense_Mutation	novel	Q3610H	0.08
OV	chr12	49046281	Missense_Mutation	novel	I1521S	0.07
OV	chr12	49039248	Nonsense_Mutation	novel	*P2781Vfs5**	0.13
PAAD	chr12	49032331	Missense_Mutation	novel	S4125F	0.15
PAAD	chr12	49051114	Missense_Mutation	novel	K857E	0.08
PAAD	chr12	49039904	Silent	rs773435188	D2622D	0.07
PAAD	chr12	49040298	Frame_Shift_Ins	novel	*A2491Gfs15**	0.21
PAAD	chr12	49022714	Missense_Mutation	rs566674356	R5405H	0.17
PAAD	chr12	49026311	Missense_Mutation	novel	L5219I	0.15
PAAD	chr12	49026613	Missense_Mutation	novel	A5118V	0.2
PAAD	chr12	49027090	Missense_Mutation	novel	A4959V	0.15
PAAD	chr12	49031718	Missense_Mutation	novel	Q4329H	0.18
PAAD	chr12	49033463	Missense_Mutation	novel	L3748I	0.16
PAAD	chr12	49041482	Missense_Mutation	novel	K2096N	0.12
PAAD	chr12	49051052	Silent	novel	P877P	0.19
PAAD	chr12	49039989	Frame_Shift_Ins	novel	*L2594Pfs61**	0.12
PAAD	chr12	49033896	Silent	NA	Q3603Q	0.11
PAAD	chr12	49052134	Frame_Shift_Del	novel	*E517Sfs413**	0.5
PRAD	chr12	49040346	Frame_Shift_Del	novel	*P2475Lfs10**	0.18
PRAD	chr12	49046648	Frame_Shift_Del	novel	*P1460Hfs46**	0.38
PRAD	chr12	49026325	Missense_Mutation	novel	R5214L	0.2
PRAD	chr12	49026326	Missense_Mutation	NA	R5214C	0.18
PRAD	chr12	49053289	Frame_Shift_Ins	novel	*C291Lfs2**	0.44
PRAD	chr12	49037176	Nonsense_Mutation	NA	Q3394*	0.16
PRAD	chr12	49051490	Frame_Shift_Del	novel	*E731Afs17**	0.34
PRAD	chr12	49034168	Missense_Mutation	novel	R3547C	0.08
PRAD	chr12	49040391	Missense_Mutation	NA	R2460L	0.18
PRAD	chr12	49048678	Frame_Shift_Del	novel	*D1371Qfs60**	0.19
PRAD	chr12	49041039	Frame_Shift_Del	novel	*F2244Sfs20**	0.2
PRAD	chr12	49026913	Missense_Mutation	novel	T5018I	0.09
PRAD	chr12	49027207	Missense_Mutation	novel	P4920R	0.15
PRAD	chr12	49034153	In_Frame_Del	novel	K3551_A3552delinsT	0.04
PRAD	chr12	49043656	Frame_Shift_Ins	novel	E1816*	0.25
PRAD	chr12	49034855	Missense_Mutation	novel	V3438L	0.1
PRAD	chr12	49050089	Nonsense_Mutation	NA	E1167*	0.17
PRAD	chr12	49022650	Nonsense_Mutation	NA	Y5426*	0.19
PRAD	chr12	49040181	Missense_Mutation	rs773982820	T2530I	0.09
PRAD	chr12	49026640	Missense_Mutation	NA	C5109F	0.31
PRAD	chr12	49037307	Frame_Shift_Del	novel	*P3345Rfs8**	0.43
PRAD	chr12	49051550	Silent	NA	P711P	0.31
PRAD	chr12	49040241	Frame_Shift_Del	novel	*V2510Afs33**	0.33
PRAD	chr12	49051192	Frame_Shift_Del	novel	*E830Dfs8**	0.24
PRAD	chr12	49022643	In_Frame_Del	novel	I5424_G5428del	0.19
PRAD	chr12	49034841	Frame_Shift_Del	novel	*M3439Ifs9**	0.26
PRAD	chr12	49053266	Nonsense_Mutation	novel	Y298*	0.29
PRAD	chr12	49051280	Frame_Shift_Del	novel	*P799Rfs128**	0.06
PRAD	chr12	49033754	Missense_Mutation	novel	Q3651K	0.13
PRAD	chr12	49026560	Missense_Mutation	novel	H5136Y	0.41
PRAD	chr12	49026713	Missense_Mutation	novel	H5085Y	0.59
PRAD	chr12	49041486	Missense_Mutation	rs374216845	R2095H	0.38
PRAD	chr12	49051890	Missense_Mutation	rs377761041	R598H	0.45
PRAD	chr12	49040714	Frame_Shift_Del	novel	*P2354Lfs30**	0.41
READ	chr12	49022331	Missense_Mutation	NA	R5454Q	0.36
READ	chr12	49048008	Missense_Mutation	NA	S1398L	0.36
READ	chr12	49033799	Missense_Mutation	NA	L3636F	0.18
READ	chr12	49037926	Missense_Mutation	rs752428122	A3144T	0.2
READ	chr12	49040709	Frame_Shift_Del	NA	*P2354Lfs30**	0.33
READ	chr12	49051702	Missense_Mutation	rs371225040	R661C	0.18
READ	chr12	49054012	Silent	NA	L213L	0.26
READ	chr12	49026644	Missense_Mutation	NA	R5108C	0.45
READ	chr12	49027010	Missense_Mutation	rs765693458	R4986C	0.39
READ	chr12	49041373	Missense_Mutation	rs781460562	A2133T	0.28
SARC	chr12	49052313	Missense_Mutation	novel	P457L	0.22
SARC	chr12	49043360	Splice_Region	novel		0.39
SARC	chr12	49032944	Frame_Shift_Del	novel	*Q3921Nfs58**	0.24
SARC	chr12	49022745	Missense_Mutation	novel	W5395R	0.29
SARC	chr12	49032926	Nonsense_Mutation	NA	Q3927*	0.42
SARC	chr12	49026325	Missense_Mutation	rs398123729	R5214H	0.13
SARC	chr12	49032239	Frame_Shift_Del	novel	*Q4156Nfs5**	0.3
SARC	chr12	49051595	Silent	novel	S696S	0.38
SARC	chr12	49038361	Missense_Mutation	novel	A2999T	0.26
SKCM	chr12	49022841	Missense_Mutation	novel	A5363T	0.4
SKCM	chr12	49022842	Silent	novel	K5362K	0.39
SKCM	chr12	49040828	Silent	NA	T2314T	0.19
SKCM	chr12	49051866	Missense_Mutation	NA	S606F	0.24
SKCM	chr12	49051370	Silent	NA	S771S	0.33
SKCM	chr12	49028091	Silent	novel	I4811I	0.13
SKCM	chr12	49030630	Missense_Mutation	NA	P4604S	0.15
SKCM	chr12	49031306	Missense_Mutation	NA	L4467F	0.36
SKCM	chr12	49040949	Missense_Mutation	rs767236217	S2274L	0.4
SKCM	chr12	49051587	Missense_Mutation	novel	S699F	0.33
SKCM	chr12	49041196	Missense_Mutation	NA	A2192T	0.36
SKCM	chr12	49051004	Silent	novel	P893P	0.16
SKCM	chr12	49022721	Missense_Mutation	NA	R5403C	0.47
SKCM	chr12	49040437	Nonsense_Mutation	novel	Q2445*	0.38
SKCM	chr12	49026743	Missense_Mutation	rs764161037	G5075R	0.63
SKCM	chr12	49033796	Missense_Mutation	novel	P3637S	0.26
SKCM	chr12	49033797	Silent	novel	L3636L	0.26
SKCM	chr12	49034139	Silent	novel	F3556F	0.31
SKCM	chr12	49051448	Silent	NA	P745P	0.29
SKCM	chr12	49039596	Silent	rs370846697	L2690L	0.57
SKCM	chr12	49054568	Silent	NA	F120F	0.47
SKCM	chr12	49026825	Silent	novel	A5047A	0.31
SKCM	chr12	49038659	Silent	rs773360383	G2899G	0.38
SKCM	chr12	49049790	Silent	novel	E1266E	0.33
SKCM	chr12	49032059	Missense_Mutation	NA	P4216S	0.1
SKCM	chr12	49033605	Silent	NA	F3700F	0.23
SKCM	chr12	49034446	Missense_Mutation	NA	R3491C	0.42
SKCM	chr12	49040207	Silent	NA	S2521S	0.1
SKCM	chr12	49050597	Silent	NA	P997P	0.27
SKCM	chr12	49051326	Missense_Mutation	rs763628850	P786L	0.33
SKCM	chr12	49051836	Missense_Mutation	NA	P616L	0.19
SKCM	chr12	49042752	Missense_Mutation	NA	P1924L	0.26
SKCM	chr12	49029146	Silent	NA	F4722F	0.4
SKCM	chr12	49027181	Missense_Mutation	novel	P4929S	0.06
SKCM	chr12	49026187	Missense_Mutation	NA	P5260L	0.19
SKCM	chr12	49050362	Missense_Mutation	NA	E1076K	0.24
SKCM	chr12	49021839	Missense_Mutation	novel	D5519N	0.38
SKCM	chr12	49050730	Missense_Mutation	novel	P953L	0.8
SKCM	chr12	49028066	Missense_Mutation	NA	P4820S	0.59
SKCM	chr12	49051090	Missense_Mutation	NA	E865K	0.32
SKCM	chr12	49049872	Missense_Mutation	NA	S1239F	0.5
SKCM	chr12	49051789	In_Frame_Del	novel	A623_E631del	0.26
SKCM	chr12	49040080	Missense_Mutation	NA	S2564R	0.36
SKCM	chr12	49050438	Silent	rs776139328	S1050S	0.37
SKCM	chr12	49051032	Missense_Mutation	rs763105209	P884L	0.45
SKCM	chr12	49031714	Missense_Mutation	NA	P4331S	0.26
SKCM	chr12	49033424	Missense_Mutation	NA	P3761S	0.25
SKCM	chr12	49040155	Missense_Mutation	NA	P2539S	0.2
SKCM	chr12	49041476	Silent	rs776324503	D2098D	0.28
SKCM	chr12	49048748	Missense_Mutation	novel	P1348T	0.26
SKCM	chr12	49048749	Silent	novel	S1347S	0.26
SKCM	chr12	49050495	Silent	NA	S1031S	0.14
SKCM	chr12	49027032	Silent	novel	R4978R	0.15
SKCM	chr12	49027237	Missense_Mutation	novel	P4910L	0.44
SKCM	chr12	49027238	Missense_Mutation	novel	P4910S	0.44
SKCM	chr12	49040841	Missense_Mutation	NA	P2310L	0.24
SKCM	chr12	49041333	Missense_Mutation	rs563981206	P2146L	0.64
SKCM	chr12	49051005	Missense_Mutation	NA	P893L	0.4
SKCM	chr12	49040354	Silent	NA	P2472P	0.18
SKCM	chr12	49041166	Missense_Mutation	NA	P2202S	0.16
SKCM	chr12	49040009	Silent	novel	F2587F	0.11
SKCM	chr12	49052072	Silent	NA	S537S	0.45
SKCM	chr12	49049811	Silent	novel	L1259L	0.28
SKCM	chr12	49031949	Silent	novel	P4252P	0.34
SKCM	chr12	49040662	Missense_Mutation	NA	R2370C	0.35
SKCM	chr12	49043765	Silent	novel	K1779K	0.38
SKCM	chr12	49050469	Missense_Mutation	NA	S1040F	0.23
SKCM	chr12	49050936	Missense_Mutation	rs765475926	P916L	0.22
SKCM	chr12	49032264	Silent	NA	S4147S	0.42
SKCM	chr12	49050548	Missense_Mutation	NA	P1014S	0.68
SKCM	chr12	49040520	Missense_Mutation	novel	S2417F	0.74
SKCM	chr12	49051447	Missense_Mutation	rs201896284	R746W	0.24
SKCM	chr12	49027226	Missense_Mutation	rs750101930	P4914S	0.43
SKCM	chr12	49038538	Missense_Mutation	novel	P2940S	0.27
SKCM	chr12	49040519	Silent	rs759825289	S2417S	0.26
SKCM	chr12	49052095	Missense_Mutation	NA	P530S	0.56
SKCM	chr12	49048037	Silent	novel	R1388R	0.21
SKCM	chr12	49048038	Missense_Mutation	rs202217665	R1388Q	0.2
SKCM	chr12	49026431	Missense_Mutation	rs794727688	R5179C	0.27
SKCM	chr12	49026432	Silent	novel	F5178F	0.28
SKCM	chr12	49031438	Missense_Mutation	NA	P4423S	0.38
SKCM	chr12	49051469	Silent	rs201219613	S738S	0.35
SKCM	chr12	49042790	Silent	NA	T1911T	0.41
SKCM	chr12	49029075	Missense_Mutation	NA	R4746Q	0.62
SKCM	chr12	49051027	Missense_Mutation	NA	P886S	0.6
SKCM	chr12	49042113	Missense_Mutation	NA	P2029S	0.15
SKCM	chr12	49054039	Silent	NA	F204F	0.9
SKCM	chr12	49031706	Silent	NA	E4333E	0.29
SKCM	chr12	49051640	Silent	NA	S681S	0.1
SKCM	chr12	49030727	Silent	novel	A4571A	0.24
SKCM	chr12	49038450	Missense_Mutation	rs762096305	S2969L	0.15
SKCM	chr12	49040868	Missense_Mutation	novel	P2301L	0.13
SKCM	chr12	49040869	Missense_Mutation	rs200681496	P2301S	0.13
SKCM	chr12	49041022	Missense_Mutation	novel	P2250S	0.52
SKCM	chr12	49052026	Missense_Mutation	rs772559303	P553S	0.38
SKCM	chr12	49040156	Silent	rs369403895	F2538F	0.28
SKCM	chr12	49038524	Missense_Mutation	novel	N2944K	0.39
SKCM	chr12	49051594	Missense_Mutation	rs755350858	P697S	0.19
SKCM	chr12	49026801	Silent	novel	D5055D	0.98
SKCM	chr12	49022287	Missense_Mutation	novel	P5469S	0.77
SKCM	chr12	49022288	Silent	novel	G5468G	0.77
SKCM	chr12	49051608	Missense_Mutation	NA	P692L	0.18
SKCM	chr12	49044415	Missense_Mutation	novel	P1691S	0.32
SKCM	chr12	49038670	Missense_Mutation	NA	P2896S	0.35
SKCM	chr12	49040958	Missense_Mutation	rs587778465	P2271L	0.25
SKCM	chr12	49051081	Missense_Mutation	NA	P868A	0.13
SKCM	chr12	49052169	Missense_Mutation	NA	P505L	0.25
SKCM	chr12	49040601	Frame_Shift_Del	novel	*P2390Rfs36**	0.37
SKCM	chr12	49026688	Missense_Mutation	novel	S5093F	0.31
SKCM	chr12	49032113	Missense_Mutation	NA	R4198G	0.44
SKCM	chr12	49041513	Missense_Mutation	rs780048854	K2086R	0.26
SKCM	chr12	49040617	Missense_Mutation	novel	P2385S	0.74
SKCM	chr12	49034606	Silent	NA	N3472N	0.19
SKCM	chr12	49050226	Missense_Mutation	NA	D1121A	0.21
SKCM	chr12	49046633	Missense_Mutation	NA	P1465L	0.5
SKCM	chr12	49041344	Missense_Mutation	novel	F2142L	0.36
SKCM	chr12	49026670	Missense_Mutation	novel	G5099D	0.4
SKCM	chr12	49028956	Missense_Mutation	NA	F4752I	0.15
SKCM	chr12	49034899	Missense_Mutation	NA	P3423L	0.15
SKCM	chr12	49049201	Silent	NA	F1308F	0.15
SKCM	chr12	49040162	Silent	novel	F2536F	0.56
SKCM	chr12	49052072	Silent	NA	S537S	0.32
SKCM	chr12	49027235	Missense_Mutation	NA	P4911S	0.25
SKCM	chr12	49038783	Missense_Mutation	NA	S2858F	0.16
SKCM	chr12	49024655	Silent	rs780850935	P5325P	0.4
SKCM	chr12	49031861	Nonsense_Mutation	NA	R4282*	0.09
SKCM	chr12	49050306	Silent	NA	L1094L	0.34
STAD	chr12	49038111	Missense_Mutation	NA	R3082Q	0.24
STAD	chr12	49027076	Missense_Mutation	rs759822794	R4964C	0.27
STAD	chr12	49053990	Frame_Shift_Del	NA	*A221Lfs40**	0.22
STAD	chr12	49028022	Missense_Mutation	NA	E4834D	0.19
STAD	chr12	49030935	Silent	rs748135755	D4543D	0.17
STAD	chr12	49040769	Missense_Mutation	rs757300574	R2334Q	0.33
STAD	chr12	49051743	Frame_Shift_Del	NA	*P647Hfs283**	0.26
STAD	chr12	49040199	Missense_Mutation	rs760263014	T2524M	0.2
STAD	chr12	49033642	Missense_Mutation	novel	G3688A	0.27
STAD	chr12	49040709	Frame_Shift_Del	NA	*P2354Lfs30**	0.3
STAD	chr12	49040222	Frame_Shift_Del	NA	*N2517Ifs26**	0.31
STAD	chr12	49038061	Missense_Mutation	rs747415183	R3099C	0.3
STAD	chr12	49022757	Silent	NA	L5391L	0.35
STAD	chr12	49054625	Frame_Shift_Del	rs797045661	*S102Afs28**	0.43
STAD	chr12	49040222	Frame_Shift_Del	NA	*N2517Ifs26**	0.37
STAD	chr12	49040709	Frame_Shift_Del	NA	*P2354Lfs30**	0.31
STAD	chr12	49031993	Missense_Mutation	rs398123714	R4238C	0.41
STAD	chr12	49049884	Frame_Shift_Del	NA	*G1235Vfs95**	0.37
STAD	chr12	49026490	Missense_Mutation	NA	R5159Q	0.23
STAD	chr12	49046667	Missense_Mutation	NA	T1454A	0.31
STAD	chr12	49054062	Frame_Shift_Ins	novel	*C197Mfs23**	0.16
STAD	chr12	49052224	Missense_Mutation	rs367559440	R487W	0.44
STAD	chr12	49026326	Missense_Mutation	NA	R5214C	0.26
STAD	chr12	49054048	Silent	rs781620078	S201S	0.25
STAD	chr12	49040601	Frame_Shift_Del	novel	*P2390Rfs36**	0.37
STAD	chr12	49050905	Silent	NA	S926S	0.18
STAD	chr12	49038060	Missense_Mutation	rs778257510	R3099H	0.23
STAD	chr12	49038643	Missense_Mutation	NA	R2905C	0.24
STAD	chr12	49040550	Missense_Mutation	NA	P2407H	0.4
STAD	chr12	49044438	Frame_Shift_Del	novel	*E1683Kfs7**	0.27
STAD	chr12	49048066	Missense_Mutation	NA	M1379V	0.07
STAD	chr12	49024654	Frame_Shift_Del	novel	*M5327Wfs6**	0.14
STAD	chr12	49034927	Missense_Mutation	novel	K3414E	0.41
STAD	chr12	49051255	Missense_Mutation	NA	T810A	0.15
STAD	chr12	49030279	Splice_Site	NA	X4667_splice	0.42
STAD	chr12	49026506	Missense_Mutation	rs768551828	R5154W	0.24
STAD	chr12	49040066	Silent	rs758460806	P2568P	0.14
STAD	chr12	49041674	Missense_Mutation	rs748389081	R2072H	0.14
STAD	chr12	49041017	Silent	rs768288559	S2251S	0.24
STAD	chr12	49049884	Frame_Shift_Del	NA	*G1235Vfs95**	0.41
STAD	chr12	49054625	Frame_Shift_Del	rs797045661	*S102Afs28**	0.38
STAD	chr12	49030958	Nonsense_Mutation	rs587783692	R4536*	0.42
STAD	chr12	49050469	In_Frame_Del	novel	S1040del	0.39
STAD	chr12	49051257	Frame_Shift_Ins	NA	*Q809Pfs3**	0.31
STAD	chr12	49052913	Splice_Site	novel	X371_splice	0.41
STAD	chr12	49044428	Frame_Shift_Del	novel	*K1686Nfs36**	0.31
STAD	chr12	49026423	Silent	NA	G5181G	0.09
STAD	chr12	49039990	Frame_Shift_Del	rs35050033	*L2594Wfs97**	0.57
STAD	chr12	49051891	Missense_Mutation	rs778514296	R598C	0.88
STAD	chr12	49038127	Frame_Shift_Ins	novel	N3077*	0.38
STAD	chr12	49048033	Frame_Shift_Del	NA	*A1390Qfs27**	0.2
STAD	chr12	49022115	Silent	rs372675867	A5483A	0.33
STAD	chr12	49033721	Missense_Mutation	novel	M3662V	0.45
STAD	chr12	49044841	Silent	rs755279282	G1622G	0.11
STAD	chr12	49046716	Silent	rs754428432	S1437S	0.44
STAD	chr12	49049844	Silent	novel	V1248V	0.38
STAD	chr12	49051026	Frame_Shift_Del	NA	*P886Lfs44**	0.38
STAD	chr12	49032154	Missense_Mutation	NA	G4184D	0.06
STAD	chr12	49026460	Missense_Mutation	NA	I5169T	0.13
STAD	chr12	49026878	Missense_Mutation	NA	R5030C	0.16
STAD	chr12	49051743	Frame_Shift_Del	NA	*P647Hfs283**	0.19
STAD	chr12	49044428	Frame_Shift_Del	novel	*K1686Nfs36**	0.33
STAD	chr12	49024860	Missense_Mutation	NA	E5291K	0.45
STAD	chr12	49046775	Silent	novel	L1418L	0.14
STAD	chr12	49046776	Missense_Mutation	rs200353763	M1417I	0.14
STAD	chr12	49051717	Frame_Shift_Del	NA	*L656Cfs274**	0.15
STAD	chr12	49032686	Nonsense_Mutation	NA	Q4007*	0.35
STAD	chr12	49026519	Frame_Shift_Del	novel	*F5149Cfs9**	0.41
STAD	chr12	49031255	Nonsense_Mutation	rs587783690	R4484*	0.18
STAD	chr12	49026326	Missense_Mutation	NA	R5214C	0.23
STAD	chr12	49049893	Missense_Mutation	NA	P1232L	0.19
STAD	chr12	49051934	Silent	rs774536143	P583P	0.08
STAD	chr12	49050964	Frame_Shift_Ins	novel	*P907Tfs63**	0.04
STAD	chr12	49051743	Frame_Shift_Del	NA	*P647Hfs283**	0.28
STAD	chr12	49040709	Frame_Shift_Del	NA	*P2354Lfs30**	0.35
STAD	chr12	49034416	Missense_Mutation	novel	V3501M	0.59
STAD	chr12	49050409	Missense_Mutation	NA	K1060T	0.12
STAD	chr12	49040709	Frame_Shift_Del	NA	*P2354Lfs30**	0.08
STAD	chr12	49050556	Missense_Mutation	rs760253122	P1011L	0.07
STAD	chr12	49031255	Nonsense_Mutation	rs587783690	R4484*	0.12
STAD	chr12	49051717	Frame_Shift_Del	NA	*L656Cfs274**	0.3
STAD	chr12	49049720	Missense_Mutation	rs769946520	R1290W	0.25
STAD	chr12	49032530	Missense_Mutation	NA	A4059T	0.3
STAD	chr12	49028113	Missense_Mutation	NA	A4804V	0.44
STAD	chr12	49033329	Frame_Shift_Del	novel	*Q3793Nfs37**	0.24
STAD	chr12	49033694	Missense_Mutation	NA	P3671S	0.23
STAD	chr12	49051366	Frame_Shift_Del	novel	*Q773Sfs157**	0.42
STAD	chr12	49044442	Nonsense_Mutation	NA	E1682*	0.3
STAD	chr12	49038091	Frame_Shift_Del	NA	*V3089Wfs30**	0.23
STAD	chr12	49040222	Frame_Shift_Del	NA	*N2517Ifs26**	0.16
STAD	chr12	49054697	Frame_Shift_Del	NA	*H77Qfs53**	0.31
STAD	chr12	49030765	Missense_Mutation	NA	L4559V	0.47
STAD	chr12	49022340	Missense_Mutation	NA	Y5451C	0.29
STAD	chr12	49026241	Missense_Mutation	NA	V5242A	0.3
STAD	chr12	49040709	Frame_Shift_Del	NA	*P2354Lfs30**	0.29
STAD	chr12	49038091	Frame_Shift_Del	NA	*V3089Wfs30**	0.23
STAD	chr12	49040136	Missense_Mutation	NA	P2545H	0.29
STAD	chr12	49051743	Frame_Shift_Del	NA	*P647Hfs283**	0.29
STAD	chr12	49031302	Missense_Mutation	NA	R4468Q	0.22
STAD	chr12	49043171	Frame_Shift_Del	novel	*G1850Afs2**	0.22
STAD	chr12	49031675	Missense_Mutation	NA	P4344S	0.21
STAD	chr12	49031509	Missense_Mutation	NA	L4399P	0.24
STAD	chr12	49041524	Silent	NA	S2082S	0.07
STAD	chr12	49052204	Silent	rs750444806	P493P	0.08
STAD	chr12	49032743	Nonsense_Mutation	NA	Q3988*	0.27
STAD	chr12	49040567	Silent	NA	R2401R	0.24
STAD	chr12	49041415	Frame_Shift_Ins	rs755159728	*A2119Rfs36**	0.27
STAD	chr12	49042790	Silent	NA	T1911T	0.17
STAD	chr12	49051717	Frame_Shift_Del	NA	*L656Cfs274**	0.18
STAD	chr12	49044284	Nonsense_Mutation	NA	R1702*	0.37
STAD	chr12	49026325	Missense_Mutation	rs398123729	R5214H	0.2
STAD	chr12	49031993	Missense_Mutation	rs398123714	R4238C	0.2
STAD	chr12	49022135	Missense_Mutation	NA	C5477G	0.13
STAD	chr12	49034161	Missense_Mutation	NA	A3549V	0.18
STAD	chr12	49040452	Missense_Mutation	rs375114492	V2440I	0.16
STAD	chr12	49040709	Frame_Shift_Del	NA	*P2354Lfs30**	0.36
STAD	chr12	49040946	Missense_Mutation	rs761636357	P2275L	0.19
STAD	chr12	49040353	Frame_Shift_Del	novel	*Q2473Sfs12**	0.19
STAD	chr12	49022117	Missense_Mutation	NA	A5483T	0.18
STAD	chr12	49027256	Nonsense_Mutation	rs398123721	R4904*	0.32
STAD	chr12	49051717	Frame_Shift_Del	NA	*L656Cfs274**	0.24
STAD	chr12	49032608	Missense_Mutation	rs778746265	V4033I	0.68
STAD	chr12	49041364	Missense_Mutation	novel	S2136P	0.61
TGCT	chr12	49026492	Silent	novel	E5158E	0.22
TGCT	chr12	49051034	Missense_Mutation	novel	F883L	0.25
THCA	chr12	49051551	Missense_Mutation	novel	P711L	0.18
THCA	chr12	49033676	Silent	novel	L3677L	0.33
THCA	chr12	49046264	Missense_Mutation	novel	E1527K	0.37
THYM	chr12	49051581	In_Frame_Del	novel	E677_E703del	0.11
UCEC	chr12	49042816	Nonsense_Mutation	NA	R1903*	0.49
UCEC	chr12	49021862	Missense_Mutation	NA	D5511A	0.31
UCEC	chr12	49024935	Missense_Mutation	novel	R5266C	0.29
UCEC	chr12	49026470	Missense_Mutation	rs758730277	A5166T	0.43
UCEC	chr12	49033586	Nonsense_Mutation	NA	R3707*	0.4
UCEC	chr12	49032828	Missense_Mutation	novel	Q3959H	0.43
UCEC	chr12	49038370	Missense_Mutation	rs756641752	D2996N	0.17
UCEC	chr12	49022598	Missense_Mutation	NA	E5444K	0.06
UCEC	chr12	49051743	Frame_Shift_Del	NA	*P647Hfs283**	0.11
UCEC	chr12	49049884	Frame_Shift_Del	NA	*G1235Vfs95**	0.59
UCEC	chr12	49021840	Silent	rs113204575	D5518D	0.39
UCEC	chr12	49022091	Missense_Mutation	novel	E5491D	0.17
UCEC	chr12	49026845	Missense_Mutation	novel	G5041R	0.21
UCEC	chr12	49031218	Missense_Mutation	rs764860964	A4496V	0.19
UCEC	chr12	49032314	Missense_Mutation	rs759729424	P4131S	0.15
UCEC	chr12	49033586	Nonsense_Mutation	NA	R3707*	0.32
UCEC	chr12	49049769	Silent	rs373373098	C1273C	0.41
UCEC	chr12	49051358	Missense_Mutation	novel	E775D	0.12
UCEC	chr12	49052054	Silent	novel	S543S	0.16
UCEC	chr12	49046399	Frame_Shift_Del	novel	*A1482Lfs24**	0.39
UCEC	chr12	49049850	Silent	rs778134618	T1246T	0.13
UCEC	chr12	49038312	Missense_Mutation	NA	G3015D	0.42
UCEC	chr12	49039590	Missense_Mutation	NA	R2692W	0.22
UCEC	chr12	49044442	Missense_Mutation	rs572314789	E1682K	0.38
UCEC	chr12	49050310	Missense_Mutation	rs747261463	P1093L	0.26
UCEC	chr12	49055291	Missense_Mutation	NA	D12Y	0.37
UCEC	chr12	49034130	Silent	novel	A3559A	0.29
UCEC	chr12	49050052	Missense_Mutation	novel	G1179D	0.5
UCEC	chr12	49048041	Missense_Mutation	NA	G1387A	0.19
UCEC	chr12	49024909	Missense_Mutation	novel	M5274I	0.35
UCEC	chr12	49051501	Frame_Shift_Del	NA	*L725Tfs2**	0.26
UCEC	chr12	49019155	3'UTR	novel		0.38
UCEC	chr12	49028025	Silent	novel	G4833G	0.29
UCEC	chr12	49037792	Silent	novel	T3188T	0.33
UCEC	chr12	49049851	Missense_Mutation	rs112921115	T1246M	0.29
UCEC	chr12	49042174	In_Frame_Del	novel	K2008del	0.39
UCEC	chr12	49049729	Frame_Shift_Del	novel	*E1287Rfs43**	0.32
UCEC	chr12	49026650	Missense_Mutation	NA	R5106C	0.46
UCEC	chr12	49028095	Missense_Mutation	NA	K4810T	0.51
UCEC	chr12	49044830	Missense_Mutation	NA	L1626W	0.48
UCEC	chr12	49040709	Frame_Shift_Del	NA	*P2354Lfs30**	0.41
UCEC	chr12	49019798	3'UTR	novel		0.46
UCEC	chr12	49020251	3'UTR	novel		0.4
UCEC	chr12	49032306	Silent	novel	L4133L	0.27
UCEC	chr12	49050427	Missense_Mutation	rs758697574	P1054L	0.55
UCEC	chr12	49041446	Silent	rs373945547	P2108P	0.44
UCEC	chr12	49053589	Missense_Mutation	novel	F242L	0.4
UCEC	chr12	49022723	Missense_Mutation	novel	A5402V	0.4
UCEC	chr12	49029174	Missense_Mutation	novel	S4713N	0.39
UCEC	chr12	49032018	Silent	novel	R4229R	0.5
UCEC	chr12	49033633	Missense_Mutation	novel	S3691Y	0.24
UCEC	chr12	49045958	Missense_Mutation	novel	A1568V	0.3
UCEC	chr12	49046159	Silent	novel	G1533G	0.45
UCEC	chr12	49049698	Missense_Mutation	rs781156556	R1297H	0.36
UCEC	chr12	49051661	Silent	rs754066539	P674P	0.39
UCEC	chr12	49052979	Missense_Mutation	novel	H350Y	0.4
UCEC	chr12	49019148	3'UTR	novel		0.26
UCEC	chr12	49027152	Silent	NA	T4938T	0.25
UCEC	chr12	49038432	Missense_Mutation	rs770885860	R2975H	0.43
UCEC	chr12	49043170	Silent	rs772395548	G1850G	0.46
UCEC	chr12	49044428	Frame_Shift_Del	novel	*K1686Nfs36**	0.34
UCEC	chr12	49046370	Nonsense_Mutation	novel	W1491*	0.42
UCEC	chr12	49050022	Missense_Mutation	NA	R1189H	0.48
UCEC	chr12	49026431	Missense_Mutation	rs794727688	R5179C	0.14
UCEC	chr12	49026485	Missense_Mutation	rs757664799	E5161K	0.41
UCEC	chr12	49022749	Silent	rs766403520	T5393T	0.23
UCEC	chr12	49026649	Missense_Mutation	rs587778486	R5106H	0.45
UCEC	chr12	49037215	Missense_Mutation	NA	P3381T	0.13
UCEC	chr12	49051879	Missense_Mutation	novel	P602S	0.06
UCEC	chr12	49053550	Silent	NA	C255C	0.3
UCEC	chr12	49049884	Frame_Shift_Del	NA	*G1235Vfs95**	0.3
UCEC	chr12	49051743	Frame_Shift_Del	NA	*P647Hfs283**	0.4
UCEC	chr12	49033391	Missense_Mutation	NA	K3772E	0.48
UCEC	chr12	49040595	Frame_Shift_Del	novel	*P2392Lfs34**	0.15
UCEC	chr12	49031551	Missense_Mutation	novel	E4385A	0.08
UCEC	chr12	49032020	Missense_Mutation	rs754805620	R4229W	0.3
UCEC	chr12	49038611	Silent	novel	R2915R	0.1
UCEC	chr12	49041162	Missense_Mutation	NA	T2203K	0.4
UCEC	chr12	49043414	Missense_Mutation	novel	D1828Y	0.04
UCEC	chr12	49043921	Missense_Mutation	rs770835064	R1756W	0.23
UCEC	chr12	49046608	Splice_Site	novel	X1473_splice	0.54
UCEC	chr12	49049190	Missense_Mutation	NA	R1312H	0.57
UCEC	chr12	49041432	Missense_Mutation	NA	L2113P	0.25
UCEC	chr12	49044867	Missense_Mutation	rs375118713	R1614W	0.34
UCEC	chr12	49037845	Missense_Mutation	novel	G3171W	0.12
UCEC	chr12	49042306	Silent	rs761930376	P1964P	0.14
UCEC	chr12	49046108	Silent	novel	G1550G	0.15
UCEC	chr12	49051653	Missense_Mutation	novel	E677A	0.12
UCEC	chr12	49040299	Frame_Shift_Del	novel	*A2491Lfs52**	0.27
UCEC	chr12	49032020	Missense_Mutation	rs754805620	R4229W	0.1
UCEC	chr12	49039616	Missense_Mutation	novel	R2683H	0.42
UCEC	chr12	49029203	Frame_Shift_Ins	novel	*D4703Efs95**	0.48
UCEC	chr12	49024578	Missense_Mutation	novel	R5351Q	0.29
UCEC	chr12	49027206	Frame_Shift_Del	novel	*L4921Wfs74**	0.2
UCEC	chr12	49033249	Missense_Mutation	rs527356550	G3819D	0.33
UCEC	chr12	49033881	Silent	rs189571290	Q3608Q	0.26
UCEC	chr12	49037793	Missense_Mutation	rs762206028	T3188M	0.16
UCEC	chr12	49038543	Missense_Mutation	rs142395705	P2938L	0.08
UCEC	chr12	49022655	Missense_Mutation	novel	E5425K	0.41
UCEC	chr12	49037559	Missense_Mutation	novel	L3266P	0.28
UCEC	chr12	49022294	Silent	NA	T5466T	0.41
UCEC	chr12	49031362	Missense_Mutation	NA	H4448R	0.32
UCEC	chr12	49044841	Silent	rs755279282	G1622G	0.36
UCEC	chr12	49038149	Silent	novel	H3069H	0.4
UCEC	chr12	49038505	Frame_Shift_Del	novel	*H2951Tfs53**	0.32
UCEC	chr12	49051053	Missense_Mutation	novel	P877H	0.14
UCEC	chr12	49019306	3'UTR	novel		0.5
UCEC	chr12	49040709	Frame_Shift_Del	NA	*P2354Lfs30**	0.31
UCEC	chr12	49049884	Frame_Shift_Del	NA	*G1235Vfs95**	0.41
UCEC	chr12	49040709	Frame_Shift_Del	NA	*P2354Lfs30**	0.5
UCEC	chr12	49020379	3'UTR	novel		0.22
UCEC	chr12	49019478	3'UTR	novel		0.45
UCEC	chr12	49040116	Missense_Mutation	novel	P2552S	0.47
UCEC	chr12	49019554	3'UTR	novel		0.34
UCEC	chr12	49026307	Missense_Mutation	rs746471452	R5220H	0.1
UCEC	chr12	49031193	Silent	novel	G4504G	0.12
UCEC	chr12	49033665	Silent	novel	Q3680Q	0.54
UCEC	chr12	49037711	Silent	rs373046231	L3215L	0.4
UCEC	chr12	49044945	Missense_Mutation	novel	E1588K	0.18
UCEC	chr12	49039723	Splice_Site	NA	X2682_splice	0.3
UCEC	chr12	49040062	Missense_Mutation	NA	P2570T	0.3
UCEC	chr12	49049884	Frame_Shift_Del	NA	*G1235Vfs95**	0.2
UCEC	chr12	49032855	Missense_Mutation	novel	Q3950H	0.52
UCEC	chr12	49053567	Frame_Shift_Del	novel	*H250Tfs11**	0.37
UCEC	chr12	49019554	3'UTR	novel		0.38
UCEC	chr12	49031189	Missense_Mutation	rs748519188	P4506S	0.11
UCEC	chr12	49032402	Silent	novel	Q4101Q	0.3
UCEC	chr12	49051511	Silent	novel	P724P	0.26
UCEC	chr12	49020611	3'UTR	novel		0.37
UCEC	chr12	49040709	Frame_Shift_Del	NA	*P2354Lfs30**	0.24
UCEC	chr12	49051177	Frame_Shift_Del	NA	*Q836Sfs94**	0.14
UCEC	chr12	49026691	Missense_Mutation	NA	C5092Y	0.09
UCEC	chr12	49019912	3'UTR	novel		0.29
UCEC	chr12	49034599	Missense_Mutation	rs370434981	A3475T	0.36
UCEC	chr12	49040263	Missense_Mutation	novel	A2503T	0.52
UCEC	chr12	49042219	Silent	novel	G1993G	0.57
UCEC	chr12	49044905	Missense_Mutation	rs749039924	R1601H	0.29
UCEC	chr12	49050022	Missense_Mutation	NA	R1189H	0.26
UCEC	chr12	49050905	Silent	NA	S926S	0.26
UCEC	chr12	49054681	Missense_Mutation	novel	R83W	0.62
UCEC	chr12	49052202	Frame_Shift_Ins	novel	*L494Hfs6**	0.14
UCEC	chr12	49044479	Frame_Shift_Del	novel	*V1670Sfs52**	0.57
UCEC	chr12	49030284	Silent	rs757519195	L4665L	0.18
UCEC	chr12	49040198	Silent	rs772878105	T2524T	0.33
UCEC	chr12	49044428	Frame_Shift_Del	novel	*K1686Nfs36**	0.29
UCEC	chr12	49033333	Missense_Mutation	NA	S3791Y	0.11
UCEC	chr12	49026676	Missense_Mutation	rs769566680	R5097Q	0.27
UCEC	chr12	49034628	Frame_Shift_Del	novel	*G3465Dfs37**	0.46
UCEC	chr12	49040975	Silent	novel	G2265G	0.09
UCEC	chr12	49049190	Missense_Mutation	NA	R1312H	0.44
UCEC	chr12	49019526	3'UTR	novel		0.44
UCEC	chr12	49031749	Missense_Mutation	novel	R4319I	0.37
UCEC	chr12	49032761	Nonsense_Mutation	novel	R3982*	0.43
UCEC	chr12	49039463	Missense_Mutation	novel	R2734Q	0.35
UCEC	chr12	49020342	3'UTR	novel		0.43
UCEC	chr12	49054677	Missense_Mutation	rs780096090	R84H	0.16
UCEC	chr12	49024823	Missense_Mutation	rs369156879	R5303H	0.29
UCEC	chr12	49032340	Missense_Mutation	novel	G4122E	0.32
UCEC	chr12	49050677	Missense_Mutation	novel	S971P	0.39
UCEC	chr12	49033942	Missense_Mutation	novel	H3588R	0.43
UCEC	chr12	49041979	Missense_Mutation	novel	R2041S	0.29
UCEC	chr12	49033896	Silent	NA	Q3603Q	0.21
UCEC	chr12	49019042	3'UTR	novel		0.18
UCEC	chr12	49019250	3'UTR	novel		0.49
UCEC	chr12	49020675	3'UTR	novel		0.52
UCEC	chr12	49021804	Missense_Mutation	novel	W5530C	0.7
UCEC	chr12	49032130	Missense_Mutation	novel	P4192H	0.32
UCEC	chr12	49033585	Missense_Mutation	rs587778477	R3707Q	0.46
UCEC	chr12	49033762	Missense_Mutation	rs758858726	P3648L	0.36
UCEC	chr12	49034241	Missense_Mutation	novel	Q3522H	0.47
UCEC	chr12	49038810	Missense_Mutation	rs370940954	A2849V	0.58
UCEC	chr12	49040442	Missense_Mutation	rs780776865	R2443H	0.44
UCEC	chr12	49040883	Missense_Mutation	novel	S2296Y	0.51
UCEC	chr12	49049790	Missense_Mutation	novel	E1266D	0.62
UCEC	chr12	49054625	Frame_Shift_Del	rs797045661	*S102Afs28**	0.46
UCEC	chr12	49032914	Missense_Mutation	novel	L3931I	0.22
UCEC	chr12	49046716	Silent	rs754428432	S1437S	0.41
UCEC	chr12	49049884	Frame_Shift_Del	NA	*G1235Vfs95**	0.57
UCEC	chr12	49049884	Frame_Shift_Del	NA	*G1235Vfs95**	0.83
UCEC	chr12	49054340	Silent	NA	G159G	0.24
UCEC	chr12	49049884	Frame_Shift_Del	NA	*G1235Vfs95**	0.26
UCEC	chr12	49038091	Frame_Shift_Del	NA	*V3089Wfs30**	0.24
UCEC	chr12	49050935	Silent	rs544109039	P916P	0.04
UCEC	chr12	49033961	Missense_Mutation	NA	R3582W	0.49
UCEC	chr12	49049884	Frame_Shift_Del	NA	*G1235Vfs95**	0.47
UCEC	chr12	49032782	In_Frame_Ins	novel	Q3974dup	0.92
UCEC	chr12	49042319	Frame_Shift_Del	NA	*G1960Afs87**	1
UCEC	chr12	49033934	Missense_Mutation	NA	L3591F	0.37
UCEC	chr12	49038427	Missense_Mutation	NA	N2977Y	0.37
UCEC	chr12	49039960	Missense_Mutation	NA	S2604G	0.1
UCEC	chr12	49049975	Missense_Mutation	rs748757592	V1205I	0.31
UCEC	chr12	49050988	Missense_Mutation	NA	A899S	0.4
UCEC	chr12	49051980	Missense_Mutation	NA	E568G	0.37
UCEC	chr12	49055312	Missense_Mutation	NA	K5Q	0.39
UCEC	chr12	49040709	Frame_Shift_Del	NA	*P2354Lfs30**	0.45
UCEC	chr12	49037375	Missense_Mutation	novel	Q3327H	0.24
UCEC	chr12	49030331	Frame_Shift_Del	NA	*E4650Sfs16**	0.53
UCEC	chr12	49040222	Frame_Shift_Del	NA	*N2517Ifs26**	0.36
UCEC	chr12	49022645	Missense_Mutation	NA	G5428D	0.43
UCEC	chr12	49043745	Missense_Mutation	rs779659959	R1786H	0.16
UCEC	chr12	49052287	Missense_Mutation	rs201512665	R466C	0.47
UCEC	chr12	49052917	Missense_Mutation	novel	S370R	0.1
UCEC	chr12	49022114	Missense_Mutation	NA	E5484K	0.42
UCEC	chr12	49033586	Nonsense_Mutation	NA	R3707*	0.42
UCEC	chr12	49054743	Missense_Mutation	rs371342351	P62L	0.46
UCEC	chr12	49027918	Frame_Shift_Del	novel	*K4843Rfs15**	0.47
UCEC	chr12	49033600	Missense_Mutation	novel	G3702D	0.3
UCEC	chr12	49049774	Silent	novel	L1272L	0.39
UCEC	chr12	49051366	Frame_Shift_Del	novel	*Q773Sfs157**	0.41
UCEC	chr12	49022628	Missense_Mutation	NA	E5434K	0.32
UCEC	chr12	49019416	3'UTR	rs147052695		0.63
UCEC	chr12	49033485	Silent	novel	Q3740Q	0.33
UCEC	chr12	49049884	Frame_Shift_Del	NA	*G1235Vfs95**	0.5
UCEC	chr12	49051743	Frame_Shift_Del	NA	*P647Hfs283**	0.18
UCEC	chr12	49038564	Frame_Shift_Del	novel	*P2931Hfs12**	0.19
UCEC	chr12	49040709	Frame_Shift_Del	NA	*P2354Lfs30**	0.31
UCEC	chr12	49020001	3'UTR	novel		0.28
UCEC	chr12	49020938	3'UTR	novel		0.22
UCEC	chr12	49038449	Silent	rs774595668	S2969S	0.15
UCEC	chr12	49040948	Silent	novel	S2274S	0.09
UCEC	chr12	49044951	Missense_Mutation	rs759873461	R1586C	0.48
UCEC	chr12	49050457	Missense_Mutation	novel	P1044H	0.28
UCEC	chr12	49054973	Missense_Mutation	novel	N35D	0.15
UCEC	chr12	49038919	Nonsense_Mutation	novel	Q2813*	0.35
UCEC	chr12	49022818	Silent	rs372456802	G5370G	0.34
UCEC	chr12	49033285	Missense_Mutation	novel	V3807A	0.37
UCEC	chr12	49038131	Silent	rs764659894	S3075S	0.24
UCEC	chr12	49044872	Missense_Mutation	novel	R1612H	0.3
UCEC	chr12	49046080	Missense_Mutation	rs746969301	V1560M	0.33
UCEC	chr12	49046424	Nonsense_Mutation	novel	W1473*	0.29
UCEC	chr12	49051743	Frame_Shift_Del	NA	*P647Hfs283**	0.44
UCEC	chr12	49032365	Nonsense_Mutation	novel	G4114*	0.27
UCEC	chr12	49039837	Nonsense_Mutation	NA	R2645*	0.53
UCEC	chr12	49024861	Silent	rs776989239	G5290G	0.17
UCEC	chr12	49027218	Silent	rs769171629	P4916P	0.36
UCEC	chr12	49038090	Frame_Shift_Ins	NA	*V3089Gfs9**	0.47
UCEC	chr12	49052207	Silent	rs554252668	S492S	0.3
UCEC	chr12	49032487	Nonsense_Mutation	novel	S4073*	0.76
UCEC	chr12	49040167	Missense_Mutation	rs780306423	R2535C	0.27
UCEC	chr12	49044945	Missense_Mutation	novel	E1588K	0.5
UCEC	chr12	49053065	Missense_Mutation	novel	R321Q	0.29
UCEC	chr12	49040359	Nonsense_Mutation	novel	R2471*	0.67
UCEC	chr12	49034875	Missense_Mutation	novel	A3431D	0.42
UCEC	chr12	49041171	Missense_Mutation	novel	P2200H	0.41
UCEC	chr12	49031302	Missense_Mutation	NA	R4468Q	0.36
UCEC	chr12	49050276	Silent	rs373466645	P1104P	0.13
UCEC	chr12	49052297	Silent	novel	P462P	0.39
UCEC	chr12	49028855	Missense_Mutation	novel	M4785I	0.22
UCEC	chr12	49034639	Missense_Mutation	novel	R3461S	0.44
UCEC	chr12	49022754	Missense_Mutation	rs761987042	R5392C	0.47
UCEC	chr12	49033656	Missense_Mutation	novel	Q3683H	0.17
UCEC	chr12	49049729	Frame_Shift_Del	novel	*E1287Rfs43**	0.22
UCEC	chr12	49051343	Silent	rs530563702	C780C	0.38
UCEC	chr12	49032060	Silent	rs774869767	S4215S	0.47
UCEC	chr12	49032255	Missense_Mutation	novel	Q4150H	0.5
UCEC	chr12	49033034	Missense_Mutation	novel	A3891T	0.47
UCEC	chr12	49048675	Missense_Mutation	rs773208892	K1372T	0.33
UCEC	chr12	49052145	Missense_Mutation	novel	S513F	0.67
UCEC	chr12	49026425	Missense_Mutation	novel	G5181W	0.17
UCEC	chr12	49027157	Missense_Mutation	novel	P4937S	0.42
UCEC	chr12	49040709	Frame_Shift_Del	NA	*P2354Lfs30**	0.71
UCEC	chr12	49053531	Missense_Mutation	NA	A262T	0.26
UCEC	chr12	49019075	3'UTR	novel		0.38
UCEC	chr12	49034843	Missense_Mutation	novel	G3442C	0.28
UCEC	chr12	49019477	3'UTR	novel		0.63
UCEC	chr12	49027218	Silent	rs769171629	P4916P	0.29
UCEC	chr12	49026453	Silent	NA	R5171R	0.12
UCEC	chr12	49041675	Missense_Mutation	NA	R2072S	0.34
UCEC	chr12	49038791	Silent	rs780023354	A2855A	0.65
UCEC	chr12	49040709	Frame_Shift_Del	NA	*P2354Lfs30**	0.53
UCEC	chr12	49051026	Frame_Shift_Del	NA	*P886Lfs44**	0.67
UCEC	chr12	49031881	Frame_Shift_Ins	NA	*Q4275Lfs59**	0.34
UCEC	chr12	49044482	Silent	rs760039365	G1668G	0.32
UCEC	chr12	49044766	Silent	rs748740454	T1647T	0.34
UCEC	chr12	49040152	Nonsense_Mutation	novel	Q2540*	0.35
UCEC	chr12	49034117	Missense_Mutation	novel	L3564F	0.36
UCEC	chr12	49038091	Frame_Shift_Del	NA	*V3089Wfs30**	0.35
UCEC	chr12	49051434	Missense_Mutation	rs767181879	P750L	0.24
UCEC	chr12	49054624	Frame_Shift_Ins	novel	*S102Efs6**	0.43
UCEC	chr12	49027901	Missense_Mutation	novel	S4849G	0.26
UCEC	chr12	49026877	Missense_Mutation	NA	R5030H	0.23
UCEC	chr12	49032040	Missense_Mutation	NA	L4222P	0.2
UCEC	chr12	49033767	Silent	NA	G3646G	0.33
UCEC	chr12	49048033	Frame_Shift_Del	NA	*A1390Qfs27**	0.52
UCEC	chr12	49051420	Frame_Shift_Del	NA	*R755Gfs175**	0.46
UCEC	chr12	49026742	Missense_Mutation	novel	G5075V	0.49
UCEC	chr12	49031350	Frame_Shift_Del	novel	*A4452Efs67**	0.18
UCEC	chr12	49039768	Missense_Mutation	novel	G2668C	0.38
UCEC	chr12	49040613	Missense_Mutation	rs763262491	R2386Q	0.09
UCEC	chr12	49049909	Missense_Mutation	novel	L1227M	0.24
UCEC	chr12	49019042	3'UTR	novel		0.33
UCEC	chr12	49031526	Silent	novel	S4393S	0.38
UCEC	chr12	49038069	Missense_Mutation	novel	P3096H	0.26
UCEC	chr12	49052178	Missense_Mutation	novel	P502H	0.29
UCEC	chr12	49034149	Missense_Mutation	NA	G3553D	0.28
UCEC	chr12	49026506	Missense_Mutation	rs768551828	R5154W	0.18
UCEC	chr12	49037760	Missense_Mutation	NA	S3199N	0.25
UCEC	chr12	49021787	Missense_Mutation	NA	M5536T	0.42
UCEC	chr12	49022105	Missense_Mutation	novel	T5487A	0.32
UCEC	chr12	49031775	Silent	novel	P4310P	0.36
UCEC	chr12	49040709	Frame_Shift_Del	NA	*P2354Lfs30**	0.37
UCEC	chr12	49049970	Silent	rs200624640	N1206N	0.41
UCEC	chr12	49040222	Frame_Shift_Del	NA	*N2517Ifs26**	0.35
UCEC	chr12	49049982	Silent	rs369602516	S1202S	0.23
UCEC	chr12	49051743	Frame_Shift_Del	NA	*P647Hfs283**	0.37
UCEC	chr12	49046644	Frame_Shift_Del	NA	*L1462Sfs44**	0.44
UCEC	chr12	49026591	Missense_Mutation	NA	F5125L	0.22
UCEC	chr12	49026943	Missense_Mutation	novel	E5008G	0.33
UCEC	chr12	49022085	Missense_Mutation	NA	K5493N	0.24
UCEC	chr12	49040709	Frame_Shift_Del	NA	*P2354Lfs30**	0.08
UCEC	chr12	49042281	Frame_Shift_Ins	novel	*W1973Mfs20**	0.29
UCEC	chr12	49044479	Frame_Shift_Del	novel	*V1670Sfs52**	0.44
UCEC	chr12	49022749	Silent	rs766403520	T5393T	0.27
UCEC	chr12	49032946	In_Frame_Ins	rs576788910	Q3919dup	0.38
UCEC	chr12	49048041	Missense_Mutation	NA	G1387A	0.5
UCEC	chr12	49032113	Nonsense_Mutation	rs587783685	R4198*	0.23
UCEC	chr12	49040006	Silent	NA	H2588H	0.36
UCEC	chr12	49049884	Frame_Shift_Del	NA	*G1235Vfs95**	0.24
UCEC	chr12	49022301	Missense_Mutation	rs267607238	T5464M	0.47
UCEC	chr12	49022818	Silent	rs372456802	G5370G	0.07
UCEC	chr12	49019042	3'UTR	novel		0.05
UCEC	chr12	49038914	Silent	novel	Q2814Q	0.15
UCEC	chr12	49040612	Silent	novel	R2386R	0.37
UCEC	chr12	49022062	Missense_Mutation	NA	R5501Q	0.34
UCEC	chr12	49022760	Missense_Mutation	NA	R5390W	0.48
UCEC	chr12	49030659	Missense_Mutation	NA	A4594V	0.24
UCEC	chr12	49032319	Missense_Mutation	novel	S4129F	0.64
UCEC	chr12	49034200	Missense_Mutation	NA	R3536H	0.38
UCEC	chr12	49039867	Nonsense_Mutation	rs794727549	R2635*	0.13
UCEC	chr12	49043731	Missense_Mutation	novel	A1791T	0.52
UCEC	chr12	49033586	Nonsense_Mutation	NA	R3707*	0.43
UCEC	chr12	49019487	3'UTR	novel		0.23
UCEC	chr12	49034446	Missense_Mutation	NA	R3491C	0.3
UCEC	chr12	49031242	Missense_Mutation	rs779247029	N4488S	0.36
UCEC	chr12	49033190	Frame_Shift_Del	novel	*Q3839Sfs42**	0.33
UCEC	chr12	49049134	Missense_Mutation	novel	S1331P	0.33
UCEC	chr12	49041416	Frame_Shift_Del	NA	*A2119Lfs25**	0.5
UCEC	chr12	49050557	Missense_Mutation	novel	P1011S	0.26
UCEC	chr12	49051177	Frame_Shift_Del	NA	*Q836Sfs94**	0.22
UCEC	chr12	49026285	Nonsense_Mutation	NA	C5227*	0.35
UCEC	chr12	49041422	Silent	novel	P2116P	0.29
UCEC	chr12	49044234	Silent	rs367970485	A1718A	0.25
UCEC	chr12	49044873	Missense_Mutation	novel	R1612C	0.11
UCEC	chr12	49051743	Frame_Shift_Del	NA	*P647Hfs283**	0.19
UCEC	chr12	49052383	Frame_Shift_Del	NA	L434*	0.68
UCEC	chr12	49037939	Frame_Shift_Del	novel	*K3140Rfs2**	0.41
UCEC	chr12	49044284	Nonsense_Mutation	NA	R1702*	0.41
UCEC	chr12	49027256	Nonsense_Mutation	rs398123721	R4904*	0.45
UCEC	chr12	49031801	Missense_Mutation	novel	L4302F	0.32
UCEC	chr12	49032095	Missense_Mutation	rs202126693	V4204I	0.45
UCEC	chr12	49033577	Missense_Mutation	rs757243984	G3710R	0.37
UCEC	chr12	49039296	Silent	novel	G2764G	0.1
UCEC	chr12	49039837	Nonsense_Mutation	NA	R2645*	0.37
UCEC	chr12	49040600	Silent	rs3741625	P2390P	0.39
UCEC	chr12	49043746	Missense_Mutation	rs748874305	R1786C	0.4
UCEC	chr12	49044427	Missense_Mutation	novel	R1687C	0.37
UCEC	chr12	49044905	Missense_Mutation	rs749039924	R1601H	0.08
UCEC	chr12	49049982	Silent	rs369602516	S1202S	0.38
UCEC	chr12	49052414	Silent	novel	G423G	0.41
UCEC	chr12	49046294	Frame_Shift_Del	novel	*E1517Rfs4**	0.38
UCEC	chr12	49046295	Missense_Mutation	novel	E1516D	0.38
UCEC	chr12	49020813	3'UTR	novel		0.35
UCEC	chr12	49021413	3'UTR	novel		0.37
UCEC	chr12	49026281	Missense_Mutation	novel	R5229C	0.39
UCEC	chr12	49040213	Silent	novel	V2519V	0.47
UCEC	chr12	49049764	Missense_Mutation	NA	A1275V	0.31
UCS	chr12	49028044	Missense_Mutation	novel	G4827D	0.41
UCS	chr12	49040290	Frame_Shift_Ins	novel	*F2494Vfs12**	0.32
UCS	chr12	49046648	Frame_Shift_Del	novel	*P1460Hfs46**	0.33
UCS	chr12	49052196	Missense_Mutation	rs774098338	P496L	0.19
UCS	chr12	49040752	Missense_Mutation	novel	P2340S	0.49
UCS	chr12	49049199	Missense_Mutation	novel	P1309L	0.41
UCS	chr12	49021831	Missense_Mutation	novel	H5521Q	0.18
UCS	chr12	49038432	Missense_Mutation	rs770885860	R2975H	0.12
UVM	chr12	49040001	Missense_Mutation	rs760007799	S2590L	0.27

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	AMP	0.1458	0.085003
READ	DEL	0.0545	0.064633
STAD	DEL	0.0952	0.22179

Survival Analysis

Cancer	P-value	Q-value
THYM	0.04	Kaplan-Meier Survival Analysis
MESO	0.031	Kaplan-Meier Survival Analysis
HNSC	0.033	Kaplan-Meier Survival Analysis
SKCM	0.044	Kaplan-Meier Survival Analysis
COAD	0.045	Kaplan-Meier Survival Analysis
PCPG	0.03	Kaplan-Meier Survival Analysis
LAML	0.046	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000167548 (Gene tree)
Gene ID: 8085
Gene Symbol: KMT2D
Alias: ALR|MLL4|CAGL114|TNRC21|MLL2
Full Name: lysine methyltransferase 2D
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 42,921 bases
Position: chr12:49,018,975-49,061,895
Accession: 7133
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a histone methyltransferase that methylates the Lys-4 position of histone H3. The encoded protein is part of a large protein complex called ASCOM, which has been shown to be a transcriptional regulator of the beta-globin and estrogen receptor genes. Mutations in this gene have been shown to be a cause of Kabuki syndrome. [provided by RefSeq, Oct 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
30400675	Disordered Regions of Mixed Lineage Leukemia 4 (MLL4) Protein Are Capable of RNA Binding.	Int J Mol Sci	2018 Nov 5	Szabo B	doi: 10.3390/ijms19113478.
17050672	Phosphorylation of the menin tumor suppressor protein on serine 543 and serine 583.	Mol Cancer Res	2006 Oct	MacConaill LE	-
28398509	MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis.	Nucleic Acids Res	2017 Jun 20	Lai B	doi: 10.1093/nar/gkx234.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000301067	KMT2D-201	19419	XM_005269162	ENSP00000301067	5537 (aa)	XP_005269219	O14686
ENST00000526209	KMT2D-202	859	-	ENSP00000435714	218 (aa)	-	H0YEF2
ENST00000549799	KMT2D-205	530	-	-	- (aa)	-	-
ENST00000549743	KMT2D-204	615	-	-	- (aa)	-	-
ENST00000547610	KMT2D-203	636	-	ENSP00000449455	145 (aa)	-	F8VWW4
ENST00000552391	KMT2D-207	860	-	-	- (aa)	-	-
ENST00000550356	KMT2D-206	445	-	-	- (aa)	-	-
ENST00000650290	KMT2D-208	513	-	ENSP00000497218	171 (aa)	-	-

Gene Model

Click here to download ENSG00000167548's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00310	Lysine degradation	KEGG
hsa04934	Cushing syndrome	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000167548	Exhalation	8E-8	26030696
ENSG00000167548	Bipolar Disorder	6E-8	28115744

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000167548	rs10875912	12	49023161	T	Percentage gas trapping	26030696	[0.057-0.123] unit decrease	0.09	EFO_0007628
ENSG00000167548	rs10875914	12	49028311	A	Intelligence (MTAG)	29326435	[0.017-0.028] unit decrease	0.0224051	EFO_0004337
ENSG00000167548	rs10875914	12	49028311	A	Cognitive performance	30038396	[0.018-0.029] unit decrease	0.0237	EFO_0008354
ENSG00000167548	rs10875914	12	49028311	G	Bipolar disorder	28115744	[1.07-1.15]	1.11	EFO_0000289
ENSG00000167548	rs10875914	12	49028311	A	General cognitive ability	29844566	z-score decrease	6.59	EFO_0004337
ENSG00000167548	rs10875915	12	49036311	T	Intelligence	29942086	z-score increase	6.808	EFO_0004337
ENSG00000167548	rs7975791	12	49019703	C	Heel bone mineral density	30598549	[0.021-0.04] unit increase	0.0301903	EFO_0009270
ENSG00000167548	rs10875912	12	49023161	?	Hair color	30595370			EFO_0007822
ENSG00000167548	rs7975791	12	49019703	T	Chronotype	30696823		1.0526386	EFO_0008328

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000167548's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	19274049.	ISM	Function
GO:0001555	oocyte growth	-	ISS	Process
GO:0003677	DNA binding	9247308.	NAS	Function
GO:0003713	transcription coactivator activity	21873635.	IBA	Function
GO:0005515	protein binding	16603732.22722839.26886794.	IPI	Function
GO:0005634	nucleus	9247308.	NAS	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006342	chromatin silencing	-	ISS	Process
GO:0006355	regulation of transcription, DNA-templated	9247308.	NAS	Process
GO:0008284	positive regulation of cell proliferation	16603732.	IMP	Process
GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway	16603732.	IMP	Process
GO:0035097	histone methyltransferase complex	14992727.	IPI	Component
GO:0042393	histone binding	21873635.	IBA	Function
GO:0042800	histone methyltransferase activity (H3-K4 specific)	21873635.	IBA	Function
GO:0042800	histone methyltransferase activity (H3-K4 specific)	-	TAS	Function
GO:0043627	response to estrogen	16603732.	IDA	Process
GO:0044212	transcription regulatory region DNA binding	16603732.	IDA	Function
GO:0044666	MLL3/4 complex	21873635.	IBA	Component
GO:0044666	MLL3/4 complex	17500065.	IDA	Component
GO:0045652	regulation of megakaryocyte differentiation	-	TAS	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	16603732.	IMP	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0048477	oogenesis	-	ISS	Process
GO:0051568	histone H3-K4 methylation	17178841.	ISS	Process
GO:1904837	beta-catenin-TCF complex assembly	-	TAS	Process

EuRBPDB

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Eesembl ID

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Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.