EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24763515	HSCARG negatively regulates the cellular antiviral RIG-I like receptor signaling pathway by inhibiting TRAF3 ubiquitination via recruiting OTUB1.	PLoS Pathog	2014 Apr 24	Peng Y	doi: 10.1371/journal.ppat.1004041
19383985	OTU Domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) deubiquitinates estrogen receptor (ER) alpha and affects ERalpha transcriptional activity.	J Biol Chem	2009 Jun 12	Stanisi V	doi: 10.1074/jbc.M109.007484
24947413	Colon cancer bears overexpression of OTUB1.	Pathol Res Pract	2014 Nov	Liu X	doi: 10.1016/j.prp.2014.05.008
26148240	OTUB1 inhibits the ubiquitination and degradation of FOXM1 in breast cancer and epirubicin resistance.	Oncogene	2016 Mar 17	Karunarathna U	doi: 10.1038/onc.2015.208
27167337	OTUB1-catalyzed deubiquitination of FOXM1 facilitates tumor progression and predicts a poor prognosis in ovarian cancer.	Oncotarget	2016 Jun 14	Wang Y	doi: 10.18632/oncotarget.9160.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr11	63997073	Silent	novel	V149V	0.2
BLCA	chr11	63997521	Missense_Mutation	novel	G264A	0.07
BLCA	chr11	63996598	Silent	rs548762142	F96F	0.29
BRCA	chr11	63997182	Missense_Mutation	rs745390279	E186K	0.1
BRCA	chr11	63988368	Silent	novel	I30I	0.19
BRCA	chr11	63996922	Missense_Mutation	NA	I135T	0.21
CESC	chr11	63986511	Nonsense_Mutation	novel	E19*	0.08
CESC	chr11	63988636	Intron	NA		0.28
CESC	chr11	63998030	3'Flank	novel		0.46
COAD	chr11	63997054	Missense_Mutation	NA	M143T	0.39
COAD	chr11	63997208	Silent	rs762922574	I194I	0.34
COAD	chr11	63997218	Missense_Mutation	rs756050985	R198W	0.39
COAD	chr11	63997089	Missense_Mutation	NA	V155L	0.4
COAD	chr11	63996590	Missense_Mutation	NA	R94W	0.23
COAD	chr11	63997627	3'UTR	novel		0.33
ESCA	chr11	63998306	3'Flank	novel		0.14
HNSC	chr11	63996629	Missense_Mutation	novel	D107N	0.22
HNSC	chr11	63997390	Silent	novel	I220I	0.23
KIRC	chr11	63997169	Silent	NA	G181G	0.13
LIHC	chr11	63988384	Silent	NA	R36R	0.16
LIHC	chr11	63986475	Nonsense_Mutation	novel	Q7*	0.12
LIHC	chr11	63997532	Missense_Mutation	novel	I268V	0.75
LUAD	chr11	63996588	Missense_Mutation	NA	Y93C	0.47
OV	chr11	63997634	3'UTR	novel		0.14
PRAD	chr11	63996885	Nonsense_Mutation	NA	E123*	0.22
PRAD	chr11	63997151	Silent	novel	L175L	0.19
READ	chr11	63997657	3'UTR	novel		0.27
SARC	chr11	63997501	Silent	novel	V257V	0.18
SARC	chr11	63997466	Missense_Mutation	novel	P246A	0.26
SKCM	chr11	63997236	Missense_Mutation	novel	C204S	0.05
SKCM	chr11	63988701	Silent	novel	V56V	0.6
SKCM	chr11	63988702	Silent	novel	L57L	0.61
SKCM	chr11	63996616	Silent	novel	E102E	0.3
SKCM	chr11	63988627	Intron	novel		0.17
SKCM	chr11	63997196	Silent	rs532509714	F190F	0.17
STAD	chr11	63996575	Missense_Mutation	novel	G89S	0.08
STAD	chr11	63997181	Silent	rs376676356	R185R	0.08
STAD	chr11	63997092	Missense_Mutation	rs751755933	A156T	0.15
STAD	chr11	63997395	Missense_Mutation	NA	A222V	0.32
STAD	chr11	63997396	Silent	NA	A222A	0.32
STAD	chr11	63996647	Missense_Mutation	rs147019398	R113W	0.41
STAD	chr11	63997772	3'Flank	novel		0.5
TGCT	chr11	63996850	Splice_Region	novel		0.34
UCEC	chr11	63996621	Missense_Mutation	novel	L104R	0.4
UCEC	chr11	63996722	Intron	novel		0.38
UCEC	chr11	63996722	Intron	novel		0.29
UCEC	chr11	63996902	Missense_Mutation	novel	Q128H	0.38
UCEC	chr11	63998385	3'Flank	novel		0.43
UCEC	chr11	63997454	Missense_Mutation	NA	G242S	0.16
UCEC	chr11	63996722	Intron	novel		0.53
UCEC	chr11	63997166	Silent	NA	S180S	0.23
UCEC	chr11	63997179	Missense_Mutation	NA	R185C	0.34
UCEC	chr11	63998366	3'Flank	novel		0.29
UCEC	chr11	63988698	Silent	rs752889774	S55S	0.2
UCEC	chr11	63998413	3'Flank	novel		0.37
UCEC	chr11	63997376	Missense_Mutation	novel	D216N	0.48
UCEC	chr11	63996648	Missense_Mutation	novel	R113Q	0.22
UCEC	chr11	63997417	Silent	novel	V229V	0.44
UCEC	chr11	63986472	Missense_Mutation	novel	P6T	0.29
UCEC	chr11	63988371	Missense_Mutation	novel	M31I	0.53
UCEC	chr11	63996784	Intron	novel		0.27
UCEC	chr11	63997153	Missense_Mutation	novel	R176Q	0.21
UCEC	chr11	63996647	Missense_Mutation	rs147019398	R113W	0.2
UCEC	chr11	63997414	Silent	rs200423792	S228S	0.38
UCEC	chr11	63988713	Silent	novel	E60E	0.22
UCS	chr11	63997514	Missense_Mutation	NA	R262W	0.35

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ESCA	AMP	0.1793	0.018342
TGCT	DEL	0.7133	0.21504
UCS	AMP	0.2857	0.0089022

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.038	Kaplan-Meier Survival Analysis
ACC	0.00071	Kaplan-Meier Survival Analysis
HNSC	0.00028	Kaplan-Meier Survival Analysis
CESC	0.034	Kaplan-Meier Survival Analysis
LAML	0.00072	Kaplan-Meier Survival Analysis
LIHC	0.002	Kaplan-Meier Survival Analysis
LGG	0.00016	Kaplan-Meier Survival Analysis
THCA	0.04	Kaplan-Meier Survival Analysis
LUAD	0.018	Kaplan-Meier Survival Analysis
UVM	0.046	Kaplan-Meier Survival Analysis
OV	0.0024	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000167770 (Gene tree)
Gene ID: 55611
Gene Symbol: OTUB1
Alias: FLJ20113|FLJ40710
Full Name: OTU deubiquitinase, ubiquitin aldehyde binding 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 15,959 bases
Position: chr11:63,985,853-64,001,811
Accession: 23077
RBP type: non-canonical RBP
Summary: The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
18954305	Structural basis and specificity of human otubain 1-mediated deubiquitination.	Biochem J	2009 Mar 1	Edelmann MJ	doi: 10.1042/BJ20081318.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000301453	OTUB1-201	2493	NR_003089	-	- (aa)	-	-
ENST00000447683	OTUB1-204	2315	-	-	- (aa)	-	-
ENST00000428192	OTUB1-203	1296	-	ENSP00000402551	271 (aa)	-	Q96FW1
ENST00000543004	OTUB1-211	1647	-	ENSP00000437453	280 (aa)	-	F5H6Q1
ENST00000422031	OTUB1-202	2297	-	ENSP00000416973	272 (aa)	-	J3KR44
ENST00000543988	OTUB1-212	1259	-	ENSP00000441328	241 (aa)	-	F5GYN4
ENST00000536443	OTUB1-207	553	-	-	- (aa)	-	-
ENST00000535715	OTUB1-206	1391	-	ENSP00000440211	286 (aa)	-	F5GYJ8
ENST00000536943	OTUB1-208	458	-	-	- (aa)	-	-
ENST00000535140	OTUB1-205	638	-	ENSP00000444968	102 (aa)	-	F5H4F3
ENST00000541478	OTUB1-210	1803	-	ENSP00000439142	170 (aa)	-	F5H3F0
ENST00000538426	OTUB1-209	1729	-	ENSP00000444357	271 (aa)	-	Q96FW1

Gene Model

Click here to download ENSG00000167770's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000167770's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000167770	OTUB1	99	34.420	WBGene00007718	otub-1	96	34.420	Caenorhabditis_elegans

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002250	adaptive immune response	-	IEA	Process
GO:0004843	thiol-dependent ubiquitin-specific protease activity	21873635.	IBA	Function
GO:0004843	thiol-dependent ubiquitin-specific protease activity	18954305.19211026.23827681.	IDA	Function
GO:0005515	protein binding	16364312.18954305.19549727.19615732.20553488.22124327.23524849.25416956.26752685.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006281	DNA repair	-	IEA	Process
GO:0006974	cellular response to DNA damage stimulus	20725033.	IDA	Process
GO:0016579	protein deubiquitination	-	TAS	Process
GO:0019784	NEDD8-specific protease activity	21873635.	IBA	Function
GO:0019784	NEDD8-specific protease activity	18954305.	IDA	Function
GO:0031625	ubiquitin protein ligase binding	20725033.	IPI	Function
GO:0043130	ubiquitin binding	21873635.	IBA	Function
GO:0043130	ubiquitin binding	19211026.	IDA	Function
GO:0070062	extracellular exosome	19056867.23533145.	HDA	Component
GO:0071108	protein K48-linked deubiquitination	21873635.	IBA	Process
GO:0071108	protein K48-linked deubiquitination	18954305.19211026.23827681.	IDA	Process
GO:0071347	cellular response to interleukin-1	-	IEA	Process
GO:1901315	negative regulation of histone H2A K63-linked ubiquitination	20725033.	IDA	Process
GO:2000780	negative regulation of double-strand break repair	20725033.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.