EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
17611393	Bridge linkage role played by CD98hc of anti-tumor drug resistance and cancer metastasis on cisplatin-resistant ovarian cancer cells.	Cancer Biol Ther	2007 Jun	Yang H	-
21750865	Expression of 4F2hc (CD98) in pulmonary neuroendocrine tumors.	Oncol Rep	2011 Oct	Kaira K	doi: 10.3892/or.2011.1384
28179310	Prognostic Significance of the Expression of CD98 (4F2hc) in Gastric Cancer.	Anticancer Res	2017 Feb	Satoh T	-
28350098	SLC3A2 is upregulated in human osteosarcoma and promotes tumor growth through the PI3K/Akt signaling pathway.	Oncol Rep	2017 May	Zhu B	doi: 10.3892/or.2017.5530
30470261	CircSLC3A2 functions as an oncogenic factor in hepatocellular carcinoma by sponging miR-490-3p and regulating PPM1F expression.	Mol Cancer	2018 Nov 23	Wang H	doi: 10.1186/s12943-018-0909-7.
22077314	Correlation of L-type amino acid transporter 1 and CD98 expression with triple negative breast cancer prognosis.	Cancer Sci	2012 Feb	Furuya M	doi: 10.1111/j.1349-7006.2011.02151.x
18813831	Inhibition of system L (LAT1/CD98hc) reduces the growth of cultured human breast cancer cells.	Oncol Rep	2008 Oct	Shennan DB	-
25041835	Association of CD98, integrin β1, integrin β3 and Fak with the progression and liver metastases of colorectal cancer.	Pathol Res Pract	2014 Oct	Sun C	doi: 10.1016/j.prp.2014.06.016
24359579	CD98hc (SLC3A2) drives integrin-dependent renal cancer cell behavior.	Mol Cancer	2013 Dec 21	Poettler M	doi: 10.1186/1476-4598-12-169.
25084765	CD147-CD98hc complex contributes to poor prognosis of non-small cell lung cancer patients through promoting cell proliferation via the PI3K/Akt signaling pathway.	Ann Surg Oncol	2014 Dec	Fei F	doi: 10.1245/s10434-014-3816-1
19777189	CD98 expression is associated with poor prognosis in resected non-small-cell lung cancer with lymph node metastases.	Ann Surg Oncol	2009 Dec	Kaira K	doi: 10.1245/s10434-009-0685-0

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr11	62881905	Missense_Mutation	novel	R247L	0.1
BLCA	chr11	62853378	5'Flank	novel		0.07
BLCA	chr11	62855018	5'Flank	novel		0.17
BLCA	chr11	62885211	Nonsense_Mutation	rs147281603	Q386*	0.39
BLCA	chr11	62855454	5'Flank	novel		0.59
BLCA	chr11	62888192	In_Frame_Del	novel	V503_A505del	0.1
BLCA	chr11	62854679	5'Flank	novel		0.44
BLCA	chr11	62855357	5'Flank	novel		0.31
BLCA	chr11	62881326	Silent	novel	V202V	0.33
BRCA	chr11	62856295	Missense_Mutation	novel	S9L	0.78
BRCA	chr11	62885495	Missense_Mutation	NA	L445V	0.38
BRCA	chr11	62855256	5'Flank	novel		0.11
BRCA	chr11	62854059	5'Flank	novel		0.29
BRCA	chr11	62853346	5'Flank	novel		0.17
BRCA	chr11	62855562	5'Flank	novel		0.19
BRCA	chr11	62884646	Silent	NA	F359F	0.33
BRCA	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.19
CESC	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.52
CESC	chr11	62855247	5'Flank	novel		0.09
CESC	chr11	62853684	5'Flank	NA		0.25
CESC	chr11	62853869	5'Flank	novel		0.28
CESC	chr11	62853430	5'Flank	novel		0.35
CESC	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.4
CESC	chr11	62882018	Missense_Mutation	novel	G285S	0.48
CESC	chr11	62885205	Missense_Mutation	rs751067361	D384N	0.42
CESC	chr11	62884457	Missense_Mutation	NA	D332N	0.24
CESC	chr11	62888462	Silent	novel	I554I	0.41
CHOL	chr11	62882038	Missense_Mutation	novel	D291E	0.37
CHOL	chr11	62888377	Missense_Mutation	novel	L526P	0.35
COAD	chr11	62885205	Missense_Mutation	rs751067361	D384N	0.26
COAD	chr11	62888464	Missense_Mutation	NA	R555H	0.14
COAD	chr11	62888655	Missense_Mutation	NA	H619Y	0.3
COAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.38
COAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.25
COAD	chr11	62882914	Missense_Mutation	NA	R303H	0.39
COAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.39
COAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.14
COAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.2
COAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.13
COAD	chr11	62888638	Missense_Mutation	rs374261898	R613H	0.32
COAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.43
COAD	chr11	62888370	Missense_Mutation	rs779207226	R524W	0.35
COAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.19
COAD	chr11	62885513	Nonsense_Mutation	novel	R451*	0.13
COAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.44
COAD	chr11	62888483	Silent	novel	E561E	0.11
COAD	chr11	62888638	Missense_Mutation	rs374261898	R613H	0.38
COAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.08
COAD	chr11	62888400	Missense_Mutation	rs753612198	R534C	0.27
COAD	chr11	62888356	Missense_Mutation	novel	L519P	0.28
ESCA	chr11	62855326	5'Flank	novel		0.23
ESCA	chr11	62855007	5'Flank	novel		0.29
ESCA	chr11	62856271	Frame_Shift_Del	novel	M1_?9	0.26
ESCA	chr11	62853512	5'Flank	novel		0.35
GBM	chr11	62885345	Missense_Mutation	NA	W430C	0.25
GBM	chr11	62885275	Missense_Mutation	novel	D407G	0.11
GBM	chr11	62885214	Frame_Shift_Ins	novel	*Q387Lfs16**	0.1
GBM	chr11	62853162	5'Flank	novel		0.34
HNSC	chr11	62853582	5'Flank	novel		0.3
HNSC	chr11	62888375	Silent	novel	R525R	0.23
HNSC	chr11	62852898	5'Flank	novel		0.39
HNSC	chr11	62853378	5'Flank	novel		0.08
HNSC	chr11	62885518	Silent	novel	L452L	0.04
HNSC	chr11	62881890	Splice_Region	novel		0.15
HNSC	chr11	62882044	Silent	novel	L293L	0.22
HNSC	chr11	62855329	5'Flank	rs750910376		0.31
HNSC	chr11	62888543	Silent	rs143862119	S581S	0.19
HNSC	chr11	62888637	Missense_Mutation	rs537183284	R613C	0.24
HNSC	chr11	62888625	Missense_Mutation	novel	L609V	0.34
HNSC	chr11	62884466	Missense_Mutation	NA	E335K	0.12
HNSC	chr11	62888369	Silent	rs755372517	F523F	0.16
HNSC	chr11	62853162	5'Flank	novel		0.64
KIRC	chr11	62856306	Missense_Mutation	NA	V13M	0.28
KIRC	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.36
KIRC	chr11	62882938	Missense_Mutation	NA	N311S	0.31
KIRC	chr11	62853906	5'Flank	NA		0.14
KIRC	chr11	62885198	Silent	NA	N381N	0.25
KIRC	chr11	62882971	Missense_Mutation	NA	Q322R	0.3
KIRP	chr11	62881394	In_Frame_Del	novel	R226_D229del	0.17
KIRP	chr11	62884635	Missense_Mutation	novel	A356T	0.33
KIRP	chr11	62884636	Missense_Mutation	novel	A356V	0.32
KIRP	chr11	62881083	Frame_Shift_Ins	rs778450636	*Q123Afs38**	0.38
KIRP	chr11	62882971	Missense_Mutation	NA	Q322R	0.36
KIRP	chr11	62855162	5'Flank	novel		0.37
LGG	chr11	62852896	5'Flank	novel		0.19
LGG	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.56
LIHC	chr11	62881330	Missense_Mutation	NA	I204V	0.34
LIHC	chr11	62881320	Silent	novel	A200A	0.25
LUAD	chr11	62881890	Splice_Region	novel		0.18
LUAD	chr11	62888340	Missense_Mutation	NA	E514K	0.16
LUAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.23
LUAD	chr11	62888648	Silent	novel	L616L	0.13
LUAD	chr11	62855564	5'Flank	novel		0.1
LUAD	chr11	62853054	5'Flank	novel		0.19
LUAD	chr11	62888762	3'UTR	novel		0.26
LUAD	chr11	62888620	Missense_Mutation	NA	S607F	0.09
LUAD	chr11	62853352	5'Flank	rs576185556		0.07
LUAD	chr11	62881916	Silent	novel	L251L	0.31
LUAD	chr11	62855217	5'Flank	NA		0.13
LUAD	chr11	62888564	Silent	novel	S588S	0.4
LUAD	chr11	62853041	5'Flank	novel		0.37
LUAD	chr11	62882947	Missense_Mutation	novel	G314V	0.42
LUAD	chr11	62855679	5'Flank	novel		0.33
LUAD	chr11	62882944	Missense_Mutation	novel	R313L	0.28
LUAD	chr11	62888591	Silent	NA	L597L	0.23
LUAD	chr11	62888213	Missense_Mutation	NA	V509L	0.37
LUAD	chr11	62885203	Missense_Mutation	novel	S383F	0.14
LUSC	chr11	62855104	5'Flank	novel		0.37
LUSC	chr11	62885278	Missense_Mutation	novel	S408F	0.23
LUSC	chr11	62853070	5'Flank	NA		0.11
LUSC	chr11	62853184	5'Flank	novel		0.14
LUSC	chr11	62856263	5'UTR	novel		0.28
LUSC	chr11	62888375	Silent	NA	R525R	0.39
LUSC	chr11	62888638	Missense_Mutation	NA	R613P	0.27
LUSC	chr11	62853294	5'Flank	novel		0.12
LUSC	chr11	62854650	5'Flank	novel		0.49
LUSC	chr11	62853159	5'Flank	novel		0.29
LUSC	chr11	62853426	5'Flank	novel		0.62
LUSC	chr11	62856305	Silent	rs148497008	V12V	0.19
LUSC	chr11	62882964	Missense_Mutation	NA	S320P	0.29
LUSC	chr11	62888549	Silent	novel	L583L	0.4
LUSC	chr11	62852987	5'Flank	novel		0.43
MESO	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.7
OV	chr11	62855029	5'Flank	novel		0.07
OV	chr11	62852909	5'Flank	novel		0.21
OV	chr11	62884505	Missense_Mutation	novel	R348W	0.04
OV	chr11	62888761	3'UTR	novel		0.37
OV	chr11	62854522	5'Flank	novel		0.14
OV	chr11	62852607	5'Flank	NA		0.56
PAAD	chr11	62881155	Missense_Mutation	novel	K145N	0.15
PAAD	chr11	62853025	5'Flank	novel		0.09
PAAD	chr11	62853014	5'Flank	novel		0.19
PCPG	chr11	62854696	5'Flank	novel		0.32
PRAD	chr11	62853577	5'Flank	novel		0.23
PRAD	chr11	62882030	Missense_Mutation	NA	D289N	0.2
READ	chr11	62853391	5'Flank	novel		0.06
READ	chr11	62855403	5'Flank	novel		0.41
SARC	chr11	62856232	5'UTR	novel		0.09
SARC	chr11	62855232	5'Flank	novel		0.12
SARC	chr11	62855487	5'Flank	novel		0.41
SKCM	chr11	62855034	5'Flank	NA		0.27
SKCM	chr11	62853253	5'Flank	novel		0.3
SKCM	chr11	62885538	Missense_Mutation	novel	T459I	0.48
SKCM	chr11	62888524	Missense_Mutation	rs138529750	S575L	0.29
SKCM	chr11	62852877	5'Flank	novel		0.33
SKCM	chr11	62888353	Missense_Mutation	NA	S518F	0.51
SKCM	chr11	62855392	5'Flank	novel		0.26
SKCM	chr11	62881300	Missense_Mutation	NA	L194F	0.88
SKCM	chr11	62852816	5'Flank	NA		0.33
SKCM	chr11	62882919	Missense_Mutation	NA	I305L	0.16
SKCM	chr11	62852997	5'Flank	rs772253656		0.41
SKCM	chr11	62854953	5'Flank	novel		0.56
SKCM	chr11	62854954	5'Flank	novel		0.57
SKCM	chr11	62852951	5'Flank	novel		0.31
STAD	chr11	62853331	5'Flank	novel		0.06
STAD	chr11	62854001	5'Flank	NA		0.17
STAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.35
STAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.29
STAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.15
STAD	chr11	62855291	5'Flank	novel		0.13
STAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.38
STAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.18
STAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.72
STAD	chr11	62885502	Missense_Mutation	rs1140538	A447V	0.09
STAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.42
STAD	chr11	62885330	Silent	novel	A425A	0.1
STAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.38
STAD	chr11	62855183	5'Flank	novel		0.08
STAD	chr11	62855220	5'Flank	novel		0.45
STAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.34
STAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.31
STAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.15
STAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.48
STAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.21
STAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.4
STAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.29
STAD	chr11	62855143	5'Flank	novel		0.26
STAD	chr11	62853222	5'Flank	novel		0.41
STAD	chr11	62888559	Missense_Mutation	novel	A587T	0.37
STAD	chr11	62881237	Missense_Mutation	NA	A173T	0.36
STAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.38
STAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.4
STAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.15
STAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.18
STAD	chr11	62888652	Missense_Mutation	NA	P618S	0.31
STAD	chr11	62853049	5'Flank	novel		0.3
STAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.12
STAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.18
STAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.21
STAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.24
STAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.24
STAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.36
STAD	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.45
THCA	chr11	62881148	Frame_Shift_Ins	novel	*V144Pfs18**	0.17
THCA	chr11	62855226	5'Flank	novel		0.08
UCEC	chr11	62882925	Missense_Mutation	NA	D307Y	0.24
UCEC	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.17
UCEC	chr11	62882047	Missense_Mutation	novel	L294F	0.32
UCEC	chr11	62881264	Missense_Mutation	novel	R182S	0.09
UCEC	chr11	62853180	5'Flank	novel		0.21
UCEC	chr11	62855629	5'Flank	rs771051574		0.48
UCEC	chr11	62853454	5'Flank	novel		0.26
UCEC	chr11	62855025	5'Flank	novel		0.21
UCEC	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.38
UCEC	chr11	62852666	5'Flank	novel		0.23
UCEC	chr11	62852957	5'Flank	novel		0.22
UCEC	chr11	62881075	Nonsense_Mutation	novel	E119*	0.37
UCEC	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.36
UCEC	chr11	62881975	Silent	NA	D270D	0.13
UCEC	chr11	62884457	Missense_Mutation	NA	D332N	0.22
UCEC	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.25
UCEC	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.41
UCEC	chr11	62881269	Nonsense_Mutation	novel	W183*	0.21
UCEC	chr11	62888401	Missense_Mutation	NA	R534H	0.11
UCEC	chr11	62853253	5'Flank	novel		0.33
UCEC	chr11	62855302	5'Flank	rs186619741		0.39
UCEC	chr11	62881140	Missense_Mutation	novel	K140N	0.38
UCEC	chr11	62884523	Missense_Mutation	novel	K354E	0.08
UCEC	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.24
UCEC	chr11	62882019	Missense_Mutation	novel	G285D	0.44
UCEC	chr11	62888677	Missense_Mutation	novel	F626S	0.24
UCEC	chr11	62888450	Silent	novel	L550L	0.2
UCEC	chr11	62884462	Silent	novel	A333A	0.32
UCEC	chr11	62888544	Missense_Mutation	novel	D582N	0.42
UCEC	chr11	62853036	5'Flank	novel		0.43
UCEC	chr11	62853128	5'Flank	novel		0.3
UCEC	chr11	62855107	5'Flank	novel		0.38
UCEC	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.44
UCEC	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.47
UCEC	chr11	62885189	Silent	novel	A378A	0.06
UCEC	chr11	62888526	Missense_Mutation	NA	A576T	0.21
UCEC	chr11	62885232	Missense_Mutation	novel	E393K	0.26
UCEC	chr11	62852818	5'Flank	novel		0.4
UCEC	chr11	62855138	5'Flank	novel		0.39
UCEC	chr11	62855329	5'Flank	rs750910376		0.48
UCEC	chr11	62884652	Silent	novel	A361A	0.43
UCEC	chr11	62882889	Intron	novel		0.2
UCEC	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.45
UCEC	chr11	62885204	Silent	rs767945415	S383S	0.41
UCEC	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.5
UCEC	chr11	62885598	Missense_Mutation	novel	L479R	0.41
UCEC	chr11	62888429	Silent	rs138892942	A543A	0.45
UCEC	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.45
UCEC	chr11	62852919	5'Flank	novel		0.26
UCEC	chr11	62853425	5'Flank	novel		0.08
UCEC	chr11	62853502	5'Flank	novel		0.11
UCEC	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.26
UCEC	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.42
UCEC	chr11	62853011	5'Flank	novel		0.17
UCEC	chr11	62854958	5'Flank	novel		0.16
UCEC	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.62
UCEC	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.34
UCEC	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.47
UCEC	chr11	62888451	Missense_Mutation	novel	F551V	0.11
UCEC	chr11	62855689	5'Flank	novel		0.46
UCEC	chr11	62856341	Silent	novel	S24S	0.09
UCEC	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.39
UCEC	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.4
UCEC	chr11	62852883	5'Flank	novel		0.17
UCEC	chr11	62853430	5'Flank	novel		0.19
UCEC	chr11	62853855	5'Flank	novel		0.22
UCEC	chr11	62854899	5'Flank	novel		0.21
UCEC	chr11	62855408	5'Flank	novel		0.22
UCEC	chr11	62881056	Missense_Mutation	novel	E112D	0.14
UCEC	chr11	62888638	Missense_Mutation	rs374261898	R613H	0.39
UCEC	chr11	62885555	Frame_Shift_Ins	novel	*S467Qfs5**	0.21
UCEC	chr11	62882057	Frame_Shift_Del	NA	*K300Rfs31**	0.39
UCEC	chr11	62853844	5'Flank	novel		0.29
UCEC	chr11	62854051	5'Flank	novel		0.07
UCEC	chr11	62855125	5'Flank	novel		0.11
UCEC	chr11	62855021	5'Flank	novel		0.09
UCEC	chr11	62853132	5'Flank	novel		0.29
UCEC	chr11	62885341	Missense_Mutation	novel	R429H	0.32
UCS	chr11	62853733	5'Flank	novel		0.2
UVM	chr11	62855112	5'Flank	novel		0.07

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ESCA	AMP	0.1685	0.018342
TGCT	DEL	0.7067	0.21504

Survival Analysis

Cancer	P-value	Q-value
STAD	0.025	Kaplan-Meier Survival Analysis
ACC	0.0056	Kaplan-Meier Survival Analysis
UCS	0.026	Kaplan-Meier Survival Analysis
HNSC	0.0047	Kaplan-Meier Survival Analysis
SKCM	0.00039	Kaplan-Meier Survival Analysis
BLCA	0.0021	Kaplan-Meier Survival Analysis
UCEC	0.0025	Kaplan-Meier Survival Analysis
LIHC	0.0014	Kaplan-Meier Survival Analysis
LGG	0.002	Kaplan-Meier Survival Analysis
LUAD	0.0009	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000168003 (Gene tree)
Gene ID: 6520
Gene Symbol: SLC3A2
Alias: 4T2HC|4F2|NACAE|CD98|CD98HC|4F2HC|MDU1
Full Name: solute carrier family 3 member 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 32,872 bases
Position: chr11:62,856,012-62,888,883
Accession: 11026
RBP type: non-canonical RBP
Summary: This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized. [provided by RefSeq, Nov 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
21282044	CD98hc (SLC3A2) is a key regulator of keratinocyte adhesion.	J Dermatol Sci	2011 Mar	Lemaitre G	doi: 10.1016/j.jdermsci.2010.12.007

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000537508	SLC3A2-209	583	-	-	- (aa)	-	-
ENST00000457660	SLC3A2-205	873	-	-	- (aa)	-	-
ENST00000542793	SLC3A2-219	539	-	-	- (aa)	-	-
ENST00000535296	SLC3A2-206	2084	-	ENSP00000444236	599 (aa)	-	F5GZS6
ENST00000536981	SLC3A2-208	1486	-	ENSP00000444439	175 (aa)	-	F5GZI0
ENST00000377891	SLC3A2-204	2222	-	ENSP00000367123	631 (aa)	-	J3KPF3
ENST00000377890	SLC3A2-203	2161	-	ENSP00000367122	630 (aa)	-	P08195
ENST00000539458	SLC3A2-213	565	-	ENSP00000438032	145 (aa)	-	F5H0E2
ENST00000546253	SLC3A2-222	582	-	-	- (aa)	-	-
ENST00000537839	SLC3A2-210	584	-	-	- (aa)	-	-
ENST00000538682	SLC3A2-212	1368	-	-	- (aa)	-	-
ENST00000535768	SLC3A2-207	597	-	-	- (aa)	-	-
ENST00000544377	SLC3A2-221	589	-	ENSP00000442135	135 (aa)	-	F5H867
ENST00000539891	SLC3A2-215	1300	-	ENSP00000438353	67 (aa)	-	F5H056
ENST00000542922	SLC3A2-220	2174	-	-	- (aa)	-	-
ENST00000546312	SLC3A2-223	564	-	-	- (aa)	-	-
ENST00000541372	SLC3A2-216	269	-	ENSP00000444250	47 (aa)	-	F5GZR9
ENST00000539507	SLC3A2-214	534	-	ENSP00000440819	122 (aa)	-	H0YFX4
ENST00000377889	SLC3A2-202	1993	-	ENSP00000367121	568 (aa)	-	P08195
ENST00000541425	SLC3A2-217	595	-	ENSP00000445858	24 (aa)	-	H0YH36
ENST00000541649	SLC3A2-218	515	-	-	- (aa)	-	-
ENST00000338663	SLC3A2-201	1904	-	ENSP00000340815	529 (aa)	-	P08195
ENST00000538084	SLC3A2-211	741	-	ENSP00000440001	247 (aa)	-	H0YFS2

Gene Model

Click here to download ENSG00000168003's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04150	mTOR signaling pathway	KEGG
hsa04216	Ferroptosis	KEGG
hsa04974	Protein digestion and absorption	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000168003	Myocardial Infarction	5.8015742E-004	-
ENSG00000168003	Myocardial Infarction	2.6274260E-004	-
ENSG00000168003	Heart Failure	6.1115535E-004	-
ENSG00000168003	Platelet Function Tests	7.4600000E-006	-
ENSG00000168003	Platelet Function Tests	2.5900000E-006	-
ENSG00000168003	Platelet Function Tests	1.1263300E-005	-
ENSG00000168003	Platelet Function Tests	1.7172800E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000168003	rs144453006	11	62887212	G	Iron status biomarkers (transferrin saturation)	28334935	[0.57-1.32] unit decrease	0.946	EFO_0006333

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000168003's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000168003	SLC3A2	100	86.667	ENSMUSG00000010095	Slc3a2	100	87.826	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0003725	double-stranded RNA binding	21266579.	IDA	Function
GO:0003824	catalytic activity	-	IEA	Function
GO:0005432	calcium:sodium antiporter activity	10673541.	TAS	Function
GO:0005515	protein binding	10506149.10631289.12270127.20374249.25998567.28298427.	IPI	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005886	plasma membrane	12270127.25998567.	IDA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0005975	carbohydrate metabolic process	-	IEA	Process
GO:0006816	calcium ion transport	3036867.	NAS	Process
GO:0006865	amino acid transport	10673541.	TAS	Process
GO:0009986	cell surface	19581412.	HDA	Component
GO:0009986	cell surface	25063885.	IDA	Component
GO:0015175	neutral amino acid transmembrane transporter activity	-	ISS	Function
GO:0015827	tryptophan transport	-	ISS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016021	integral component of membrane	3476959.	NAS	Component
GO:0016324	apical plasma membrane	-	IEA	Component
GO:0035725	sodium ion transmembrane transport	-	IEA	Process
GO:0042470	melanosome	-	IEA	Component
GO:0043330	response to exogenous dsRNA	21266579.	IMP	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0050900	leukocyte migration	-	TAS	Process
GO:0070062	extracellular exosome	19056867.19199708.20458337.23533145.	HDA	Component
GO:1902475	L-alpha-amino acid transmembrane transport	-	TAS	Process
GO:1903801	L-leucine import across plasma membrane	-	ISS	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.