EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
26209608Quantitative Mass Spectrometry Reveals that Intact Histone H1 Phosphorylations are Variant Specific and Exhibit Single Molecule Hierarchical Dependence.Mol Cell Proteomics2016 MarChen Ydoi: 10.1074/mcp.M114.046441

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr626156694Missense_MutationnovelS102T0.52
ACCchr626156817Missense_MutationnovelG143W0.27
BLCAchr626156957SilentnovelA189A0.11
BLCAchr626156698Missense_Mutationrs776601380G103A0.1
BLCAchr626156453Silentrs201889498K21K0.23
BLCAchr626156717Missense_MutationNAK109N0.28
BLCAchr626157041Missense_MutationnovelK217N0.61
BLCAchr626157026Missense_MutationnovelK212N0.13
BLCAchr626156602Missense_MutationNAY71C0.31
BLCAchr626156717Missense_MutationNAK109N0.24
BLCAchr626156957SilentNAA189A0.37
BRCAchr626156572Missense_Mutationrs768767088A61V0.34
BRCAchr626157011In_Frame_DelnovelA208_A214del0.31
BRCAchr626156657Missense_MutationNAS89R0.29
BRCAchr626156675SilentnovelQ95Q0.1
CESCchr626156864Silentrs781387925A158A0.14
CESCchr626156514Missense_MutationNAE42Q0.86
CESCchr626156695Missense_Mutationrs766257287S102L0.19
CESCchr626156436Nonsense_MutationNAE16*0.2
CESCchr626156543Silentrs762056816S51S0.36
CESCchr626156456Silentrs780842942K22K0.36
COADchr626156406Missense_MutationnovelP6T0.75
COADchr626156872In_Frame_DelnovelA163_A165del0.15
COADchr626156922Missense_MutationNAA178T0.14
COADchr626156933Frame_Shift_DelNAK183Rfs*?0.28
COADchr626157009In_Frame_DelnovelA208_K212del0.47
COADchr626156976Missense_MutationNAP196A0.11
COADchr626156849Silentrs759116050K153K0.46
COADchr626156959Missense_MutationNAK190R0.33
COADchr626156910Frame_Shift_DelnovelK175Rfs*?0.22
DLBCchr626156672Silentrs549787183V94V0.26
DLBCchr626156701Missense_MutationnovelS104C0.22
DLBCchr626156880Missense_Mutationrs201935674A164T0.31
DLBCchr626156802Missense_MutationnovelP138S0.24
DLBCchr626156757Missense_MutationnovelA123P0.27
DLBCchr626156880Missense_Mutationrs201935674A164T0.32
DLBCchr626156529Missense_Mutationrs547695315A47P0.12
DLBCchr626156784Missense_MutationnovelA132T0.21
DLBCchr626156517Missense_MutationNAL43V0.22
DLBCchr626156756Silentrs200272831K122K0.38
ESCAchr626156592Missense_MutationnovelA68S0.1
HNSCchr626156398Missense_MutationnovelE3V0.54
HNSCchr626156577In_Frame_DelnovelK64del0.28
HNSCchr626156971Missense_MutationNAV194A0.39
HNSCchr626156546Silentrs753419578K52K0.11
HNSCchr626156942SilentnovelA184A0.2
LGGchr626156755Frame_Shift_DelnovelK122Sfs*730.13
LGGchr626156498SilentnovelS36S0.32
LGGchr626156536Missense_Mutationrs776712433A49V0.2
LGGchr626157046Nonstop_Mutationnovel*220delext*?0.1
LIHCchr626156713Missense_MutationnovelN108T0.38
LIHCchr626156539In_Frame_DelnovelS51del0.32
LUADchr626156469Missense_MutationnovelS27T0.08
LUADchr626156857Missense_MutationNAK156R0.4
LUADchr626157050SilentNA*220*0.2
LUADchr626157048Nonstop_Mutationnovel*220Kext*?0.18
LUADchr626156579Silentrs535188796K63K0.1
LUADchr626156464Missense_MutationNAR25P0.77
LUADchr626156569Missense_MutationnovelA60D0.16
LUADchr626156849Silentrs759116050K153K0.16
LUSCchr626156550Missense_MutationNAR54C0.13
LUSCchr626156436Nonsense_MutationNAE16*0.82
LUSCchr626156919Nonsense_MutationNAK177*0.33
MESOchr626156430Missense_MutationnovelP14S0.19
OVchr626156562Missense_MutationNAS58P0.92
OVchr626156572Missense_MutationNAA61D0.36
PAADchr626156955Missense_Mutationrs372876447A189T0.16
PAADchr626156753Missense_MutationnovelK121N0.1
PAADchr626156754Nonsense_MutationnovelK122*0.11
SKCMchr626157033Missense_MutationnovelA215T0.12
SKCMchr626156580Missense_MutationnovelK64E0.29
SKCMchr626156656In_Frame_InsnovelL93_T99dup0.09
SKCMchr626156717SilentnovelK109K0.35
SKCMchr626156760Missense_MutationnovelG124S0.85
SKCMchr626156761Missense_MutationnovelG124D0.84
SKCMchr626156459Frame_Shift_DelnovelA24Pfs*650.21
SKCMchr626156669Silentrs752928702L93L0.23
SKCMchr626156503Missense_Mutationrs771979983P38L0.22
SKCMchr626156747SilentNAK119K0.27
STADchr626156713Missense_MutationNAN108S0.24
STADchr626156898Missense_MutationNAA170S0.2
STADchr626156748Missense_Mutationrs777376445A120T0.39
STADchr626156867Missense_MutationnovelK159N0.28
STADchr626156472Missense_MutationNAA28S0.29
STADchr626156922Missense_MutationNAA178T0.31
STADchr626156470Missense_Mutationrs766435782S27F0.1
STADchr626156971Missense_MutationNAV194A0.15
STADchr626156988Missense_MutationNAK200E0.21
STADchr626156414Silentrs760212562A8A0.16
THCAchr626156519Silentrs756055232L43L0.24
THCAchr626156480SilentNAA30A0.38
UCECchr626156670Missense_MutationNAV94L0.39
UCECchr626156862Missense_MutationNAA158T0.2
UCECchr626156849Missense_MutationnovelK153N0.21
UCECchr626157033Missense_MutationnovelA215T0.71
UCECchr626156464Missense_Mutationrs761734336R25H0.87
UCECchr626156587Missense_MutationnovelL66P0.31
UCECchr626157025Missense_MutationnovelK212R0.25
UCECchr626156620Missense_MutationnovelN77S0.45
UCECchr626156785Missense_Mutationrs373468962A132V0.16
UCECchr626156501Frame_Shift_InsnovelV40Gfs*70.36
UCECchr626156676Missense_MutationNAT96S0.24
UCECchr626156565Missense_MutationnovelL59V0.23
UCECchr626156685Missense_MutationnovelT99A0.51
UCECchr626156526Missense_Mutationrs778623700K46E0.22

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CESCDEL0.11530.046699

Survival Analysis
CancerP-value Q-value
STAD0.011

Kaplan-Meier Survival Analysis

SARC0.0081

Kaplan-Meier Survival Analysis

ACC0.00014

Kaplan-Meier Survival Analysis

ESCA0.00027

Kaplan-Meier Survival Analysis

KIRP0.00057

Kaplan-Meier Survival Analysis

COAD0.0093

Kaplan-Meier Survival Analysis

PAAD0.046

Kaplan-Meier Survival Analysis

BLCA0.039

Kaplan-Meier Survival Analysis

LIHC0.017

Kaplan-Meier Survival Analysis

DLBC0.045

Kaplan-Meier Survival Analysis

LGG0.0023

Kaplan-Meier Survival Analysis

LUAD0.0099

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000168298 (Gene tree)
Gene ID
3008
Gene Symbol
HIST1H1E
Alias
H1.4|H1e|H1s-4|H1F4
Full Name
histone cluster 1 H1 family member e
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
785 bases
Position
chr6:26,156,331-26,157,115
Accession
4718
RBP type
non-canonical RBP
Summary
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
23682076Progesterone enhances calcitriol antitumor activity by upregulating vitamin D receptor expression and promoting apoptosis in endometrial cancer cells.Cancer Prev Res (Phila)2013 JulLee LRdoi: 10.1158/1940-6207.CAPR-12-0493
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000304218HIST1H1E-201754-ENSP00000307705219 (aa)-P10412
Gene Model
Click here to download ENSG00000168298's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000168298Body Height8E-2225282103
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000168298's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000168298HIST1H1E5397.391ENSMUSG00000051627Hist1h1e5397.391Mus_musculus
ENSG00000168298HIST1H1E5393.966ENSMUSG00000052565Hist1h1d5294.828Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000122negative regulation of transcription by RNA polymerase II21873635.IBAProcess
GO:0000788nuclear nucleosome21873635.IBAComponent
GO:0003690double-stranded DNA binding21873635.IBAFunction
GO:0003723RNA binding22681889.HDAFunction
GO:0005509calcium ion binding21873635.IBAFunction
GO:0005515protein binding21873635.IBAFunction
GO:0005515protein binding15469825.17474147.17540172.IPIFunction
GO:0005524ATP binding21873635.IBAFunction
GO:0005525GTP binding21873635.IBAFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus17540172.IDAComponent
GO:0005720nuclear heterochromatin21873635.IBAComponent
GO:0005720nuclear heterochromatin15911621.IDAComponent
GO:0006334nucleosome assembly-IEAProcess
GO:0006355regulation of transcription, DNA-templated21873635.IBAProcess
GO:0016208AMP binding21873635.IBAFunction
GO:0016584nucleosome positioning21873635.IBAProcess
GO:0030261chromosome condensation21873635.IBAProcess
GO:0031490chromatin DNA binding15911621.IMPFunction
GO:0031492nucleosomal DNA binding21873635.IBAFunction
GO:0031936negative regulation of chromatin silencing21873635.IBAProcess
GO:0032564dATP binding-IEAFunction
GO:0043531ADP binding21873635.IBAFunction
GO:0045910negative regulation of DNA recombination21873635.IBAProcess
GO:0080182histone H3-K4 trimethylation21873635.IBAProcess
GO:0098532histone H3-K27 trimethylation21873635.IBAProcess
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