EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
19010819Overexpression and hypomethylation of flap endonuclease 1 gene in breast and other cancers.Mol Cancer Res2008 NovSingh Pdoi: 10.1158/1541-7786.MCR-08-0269.
29937070Base Excision Repair Gene Polymorphisms and Wilms Tumor Susceptibility.EBioMedicine2018 JulZhu Jdoi: 10.1016/j.ebiom.2018.06.018
27270424The FEN1 L209P mutation interferes with long-patch base excision repair and induces cellular transformation.Oncogene2017 Jan 12Sun Hdoi: 10.1038/onc.2016.188
29037854Overexpression of Flap Endonuclease 1 Correlates with Enhanced Proliferation and Poor Prognosis of Non-Small-Cell Lung Cancer.Am J Pathol2018 JanZhang Kdoi: 10.1016/j.ajpath.2017.09.011
25154853FEN1 -69G>A and 4150G>T polymorphisms and cancer risk in Chinese population.Sci Rep2014 Aug 26Gao XRdoi: 10.1038/srep06183.
19218431Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing.Proc Natl Acad Sci U S A2009 Mar 3McManus KJdoi: 10.1073/pnas.0813414106
25922071Flap Endonuclease 1 Limits Telomere Fragility on the Leading Strand.J Biol Chem2015 Jun 12Teasley DCdoi: 10.1074/jbc.M115.647388
24880630Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer.Mol Oncol2014 OctAbdel-Fatah TMdoi: 10.1016/j.molonc.2014.04.009
19618370Functional FEN1 polymorphisms are associated with DNA damage levels and lung cancer risk.Hum Mutat2009 SepYang Mdoi: 10.1002/humu.21060.
26668074Variants and haplotypes in Flap endonuclease 1 and risk of gallbladder cancer and gallstones: a population-based study in China.Sci Rep2015 Dec 15Jiao Xdoi: 10.1038/srep18160.
14562054Increased expression and no mutation of the Flap endonuclease (FEN1) gene in human lung cancer.Oncogene2003 Oct 16Sato M-
23382697An evolutionarily conserved synthetic lethal interaction network identifies FEN1 as a broad-spectrum target for anticancer therapeutic development.PLoS Genet2013van Pel DMdoi: 10.1371/journal.pgen.1003254
24440783Association of functional FEN1 genetic variants and haplotypes and breast cancer risk.Gene2014 Mar 15Lv Zdoi: 10.1016/j.gene.2014.01.025
28371273FEN1 promotes tumor progression and confers cisplatin resistance in non-small-cell lung cancer.Mol Oncol2017 JunHe Ldoi: 10.1002/1878-0261.12058
27801669FEN1 gene variants confer reduced risk of breast cancer in chinese women: A case-control study.Oncotarget2016 Nov 22Lin Sdoi: 10.18632/oncotarget.12948.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1161795916Missense_MutationnovelF185L0.36
BLCAchr1161795693Missense_MutationnovelL111P0.15
BLCAchr1161796199Missense_Mutationrs764028854H280Y0.18
BRCAchr1161795468Missense_MutationnovelS36C0.5
BRCAchr1161796149Missense_MutationNAL263H0.36
CESCchr1161795862SilentNAV167V0.42
CESCchr1161796498Frame_Shift_DelnovelK380Nfs*210.29
CESCchr1161796138SilentnovelI259I0.49
CESCchr11617967493'UTRnovel0.67
CESCchr11617927535'UTRnovel0.6
CESCchr1161795829SilentNAP156P0.48
COADchr1161795421Missense_MutationNAE20D0.33
COADchr1161795718Silentrs745612425A119A0.27
COADchr11617972243'UTRnovel0.31
COADchr1161795646Silentrs371846488G95G0.36
COADchr1161795968Missense_MutationNAP203S0.28
COADchr11617971853'UTRrs1909604070.34
COADchr1161796094Missense_MutationnovelR245G0.39
COADchr1161796370Missense_MutationnovelQ337K0.13
COADchr1161796377Missense_Mutationrs573495657R339H0.15
ESCAchr1161795929SilentnovelL190L0.22
GBMchr1161795473Missense_MutationnovelS38R0.06
GBMchr1161795646SilentnovelG95G0.09
HNSCchr1161795791Missense_MutationnovelL144V0.18
HNSCchr1161796425Missense_MutationnovelR355L0.17
KIRCchr1161796163Frame_Shift_InsnovelP269Tfs*290.38
KIRPchr11617968343'UTRnovel0.42
LIHCchr1161796377Missense_Mutationrs573495657R339H0.37
LIHCchr11617969823'UTRnovel0.42
LIHCchr1161795847SilentNAS162S0.34
LUADchr1161796360Missense_MutationNAQ333H0.31
LUSCchr1161795598Missense_MutationnovelI79M0.15
LUSCchr1161796123Missense_MutationnovelK254N0.13
OVchr1161796314Missense_MutationNAE318V0.33
OVchr1161795443Missense_MutationNAG28C0.14
READchr1161796347Missense_MutationnovelS329N0.47
SARCchr1161796138SilentnovelI259I0.23
SKCMchr1161796167Missense_Mutationrs138109450P269L0.17
SKCMchr1161795717Missense_MutationNAA119V0.63
SKCMchr1161796440Missense_MutationNAP360L0.25
SKCMchr1161796186SilentNAL275L0.36
SKCMchr1161796045SilentNAI228I0.33
SKCMchr1161795578Missense_Mutationrs145709748R73C0.35
STADchr1161795936Missense_Mutationrs778764875R192Q0.19
STADchr1161795959Frame_Shift_DelnovelK201Sfs*90.26
STADchr1161795836Missense_Mutationrs778852873A159T0.35
STADchr1161796425Missense_Mutationrs761723999R355H0.35
STADchr1161796320Missense_MutationNAR320Q0.14
STADchr1161796326Missense_Mutationrs756180049R322H0.48
STADchr1161795669Missense_Mutationrs762018999R103Q0.43
STADchr1161795466SilentNAA35A0.11
THYMchr1161796255Missense_MutationnovelW298C0.09
UCECchr1161796498SilentnovelG379G0.33
UCECchr11617971683'UTRnovel0.14
UCECchr1161796129Silentrs548432286I256I0.32
UCECchr11617927065'UTRnovel0.5
UCECchr1161796319Nonsense_Mutationrs751470906R320*0.43
UCECchr1161796002Missense_MutationNAQ214P0.3
UCECchr1161796049SilentnovelL230L0.53
UCECchr1161796319Nonsense_Mutationrs751470906R320*0.55
UCECchr11617968253'UTRrs5592788520.41
UCECchr11617972243'UTRnovel0.47
UCECchr11617966003'UTRnovel0.18
UCECchr1161796436Nonsense_MutationnovelE359*0.46
UCECchr1161796139Missense_Mutationrs371695318V260M0.22
UCECchr11617953525'UTRnovel0.14
UCECchr1161796354SilentNAS331S0.16
UCECchr1161796103Missense_MutationnovelD248N0.24
UCECchr1161796210SilentnovelF283F0.21
UCECchr1161796404Missense_MutationnovelG348D0.19
UCECchr1161795341Splice_Regionnovel0.43
UCECchr1161795582Missense_MutationnovelM74T0.4
UCECchr11617968123'UTRnovel0.34
UCECchr11617970213'UTRnovel0.28
UCECchr1161796357SilentnovelR332R0.26

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ESCAAMP0.17390.018342
TGCTDEL0.70.21504

Survival Analysis
CancerP-value Q-value
THYM0.01

Kaplan-Meier Survival Analysis

STAD0.0014

Kaplan-Meier Survival Analysis

MESO0.00017

Kaplan-Meier Survival Analysis

ACC0.0001

Kaplan-Meier Survival Analysis

KIRP0.00011

Kaplan-Meier Survival Analysis

PAAD0.01

Kaplan-Meier Survival Analysis

PCPG0.023

Kaplan-Meier Survival Analysis

CESC0.041

Kaplan-Meier Survival Analysis

LAML0.0037

Kaplan-Meier Survival Analysis

KICH0.025

Kaplan-Meier Survival Analysis

LIHC0.00011

Kaplan-Meier Survival Analysis

DLBC0.041

Kaplan-Meier Survival Analysis

LGG0.0014

Kaplan-Meier Survival Analysis

THCA0.044

Kaplan-Meier Survival Analysis

LUAD0.0006

Kaplan-Meier Survival Analysis

UVM0.0008

Kaplan-Meier Survival Analysis

OV0.002

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000168496 (Gene tree)
Gene ID
2237
Gene Symbol
FEN1
Alias
FEN-1|MF1|RAD2
Full Name
flap structure-specific endonuclease 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
4,608 bases
Position
chr11:61,792,637-61,797,244
Accession
3650
RBP type
non-canonical RBP
Summary
The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000535307FEN1-202768-ENSP00000460402154 (aa)-I3L3E9
ENST00000535723FEN1-203776-ENSP00000445692165 (aa)-F5H1Y3
ENST00000305885FEN1-2012296-ENSP00000305480380 (aa)-P39748
Gene Model
Click here to download ENSG00000168496's gene model file
Pathways
Pathway IDPathway NameSource
hsa03030DNA replicationKEGG
hsa03410Base excision repairKEGG
hsa03450Non-homologous end-joiningKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000168496alpha-Linolenic Acid8.5920000E-06021829377
ENSG00000168496Docosahexaenoic Acids5.2470000E-00621829377
ENSG00000168496docosapentaenoic acid1.3800000E-13921829377
ENSG00000168496Eicosapentaenoic Acid5.9610000E-05521829377
ENSG00000168496Metabolism9E-1424816252
ENSG00000168496Platelet Count3E-1022139419
ENSG00000168496Eicosapentaenoic Acid6E-5521829377
ENSG00000168496Eicosapentaenoic Acid5E-5821829377
ENSG00000168496alpha-Linolenic Acid9E-6021829377
ENSG00000168496docosapentaenoic acid1E-13921829377
ENSG00000168496Trans Fatty Acids5E-1325646338
ENSG00000168496Trans Fatty Acids1E-1225646338
ENSG00000168496Insulin Resistance3E-923378610
ENSG00000168496Inflammatory Bowel Diseases2E-1523128233
ENSG00000168496Fatty Acids1E-925500335
ENSG00000168496Linoleic Acid1E-925500335
ENSG00000168496Trans Fatty Acids4E-1325646338
ENSG00000168496Crohn Disease9E-728067908
ENSG00000168496Fatty Acids3E-1925500335
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000168496rs42462151161796827TPlatelet count22139419[1.69-3.22] 10^9/l increase2.451EFO_0004309
ENSG00000168496rs42462151161796827?Crohn's disease28067908EFO_0000384
ENSG00000168496rs42462151161796827TPlasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid)21829377[NR] % increase0.02EFO_0007759
ENSG00000168496rs42462151161796827TPlasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid)21829377[NR] % decrease0.08EFO_0007760
ENSG00000168496rs42462151161796827TPlasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid)21829377[NR] % decrease0.07EFO_0006809
ENSG00000168496rs42462151161796827TInflammatory bowel disease23128233[1.046-1.112]1.079EFO_0003767
ENSG00000168496rs42462151161796827?Red blood cell fatty acid levels25500335[NR] unit increase0.113EFO_0005110|EFO_0006807
ENSG00000168496rs42462151161796827TTrans fatty acid levels25646338[0.0023-0.0039] unit increase0.0031EFO_0006824|EFO_0006821
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000168496's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000168496FEN110069.697FBgn0025832Fen110062.857Drosophila_melanogaster
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000287magnesium ion binding21873635.IBAFunction
GO:0000724double-strand break repair via homologous recombination-TASProcess
GO:0000784nuclear chromosome, telomeric region19135898.HDAComponent
GO:0000784nuclear chromosome, telomeric region24270157.IDAComponent
GO:0003677DNA binding11986308.IMPFunction
GO:0003684damaged DNA binding8007985.TASFunction
GO:0003690double-stranded DNA binding8131753.TASFunction
GO:0004519endonuclease activity8131753.TASFunction
GO:0004523RNA-DNA hybrid ribonuclease activity21873635.IBAFunction
GO:0004523RNA-DNA hybrid ribonuclease activity7961795.IDAFunction
GO:0004527exonuclease activity9778254.TASFunction
GO:0005515protein binding9305916.11430825.11598021.14657243.14688284.15576034.18499658.18692475.22551069.26496610.26751069.29997244.IPIFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus7961795.18995831.IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005730nucleolus-IDAComponent
GO:0005739mitochondrion18995831.IDAComponent
GO:0006260DNA replication9778254.TASProcess
GO:0006281DNA repair8007985.TASProcess
GO:0006284base-excision repair-IEAProcess
GO:0006302double-strand break repair8131753.TASProcess
GO:0007613memory-IEAProcess
GO:0008309double-stranded DNA exodeoxyribonuclease activity8131753.TASFunction
GO:00084095'-3' exonuclease activity21873635.IBAFunction
GO:00084095'-3' exonuclease activity7961795.IDAFunction
GO:0009650UV protection8007985.TASProcess
GO:0016020membrane19946888.HDAComponent
GO:00171085'-flap endonuclease activity21873635.IBAFunction
GO:00171085'-flap endonuclease activity18995831.IDAFunction
GO:00171085'-flap endonuclease activity8621570.11986308.IMPFunction
GO:00171085'-flap endonuclease activity-TASFunction
GO:0030145manganese ion binding21873635.IBAFunction
GO:0032201telomere maintenance via semi-conservative replication-TASProcess
GO:0032991protein-containing complex25378300.IDAComponent
GO:0043137DNA replication, removal of RNA primer18995831.IDAProcess
GO:0045876positive regulation of sister chromatid cohesion18499658.IMPProcess
GO:0048256flap endonuclease activity21873635.IBAFunction
GO:0048256flap endonuclease activity18499658.IDAFunction
GO:0090305nucleic acid phosphodiester bond hydrolysis18499658.IDAProcess
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic-IEAProcess
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us