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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
27769057The relationship between total and phosphorylated STAT1 and STAT3 tumour cell expression, components of tumour microenvironment and survival in patients with invasive ductal breast cancer.Oncotarget2016 Nov 22Gujam FJdoi: 10.18632/oncotarget.12730.
25977172Effect of STAT3 inhibition on the metabolic switch in a highly STAT3-activated lymphoma cell line.Cancer Genomics Proteomics2015 May-JunAkiyama Y-
27678454Signal Transduction and Activator of Transcription-3 (STAT3) in Patients with Colorectal Cancer: Associations with the Phenotypic Features of the Tumor and Host.Clin Cancer Res2017 Apr 1Park JHdoi: 10.1158/1078-0432.CCR-16-1416
28544312C-X-C motif chemokine receptor 4 promotes tumor angiogenesis in gastric cancer via activation of JAK2/STAT3.Cell Biol Int2017 AugZhang Qdoi: 10.1002/cbin.10794
20167868Transcription factor Stat3 stimulates metastatic behavior of human prostate cancer cells in vivo, whereas Stat5b has a preferential role in the promotion of prostate cancer cell viability and tumor growth.Am J Pathol2010 AprGu Ldoi: 10.2353/ajpath.2010.090653
26549725miR-21: A gene of dual regulation in breast cancer.Int J Oncol2016 JanZhang Cdoi: 10.3892/ijo.2015.3232
26238950miR-519d-mediated downregulation of STAT3 suppresses breast cancer progression.Oncol Rep2015 OctDeng Xdoi: 10.3892/or.2015.4160
27775077The cancer/testis antigen MAGEC2 promotes amoeboid invasion of tumor cells by enhancing STAT3 signaling.Oncogene2017 MarSong Xdoi: 10.1038/onc.2016.314
28784136Secretory RAB GTPase 3C modulates IL6-STAT3 pathway to promote colon cancer metastasis and is associated with poor prognosis.Mol Cancer2017 Aug 7Chang YCdoi: 10.1186/s12943-017-0687-7.
29575809IL-37 inhibits invasion and metastasis in non-small cell lung cancer by suppressing the IL-6/STAT3 signaling pathway.Thorac Cancer2018 MayJiang Mdoi: 10.1111/1759-7714.12628
22547065Suppressor of cytokine signaling 3 inhibits breast tumor kinase activation of STAT3.J Biol Chem2012 Jun 15Gao Ydoi: 10.1074/jbc.M111.334144
26775116Colorectal cancer cell-derived interleukin-6 enhances the phagocytic capacity and migration of THP-1 cells.Cytokine2016 MarYeh KYdoi: 10.1016/j.cyto.2016.01.001
18947877The combination of IL-21 and IFN-alpha boosts STAT3 activation, cytotoxicity and experimental tumor therapy.Mol Immunol2009 FebEriksen KWdoi: 10.1016/j.molimm.2008.09.006
25261365Inhibition of STAT3 signaling targets both tumor-initiating and differentiated cell populations in prostate cancer.Oncotarget2014 Sep 30Han Z-
24676538Downregulation of LKB1 suppresses Stat3 activity to promote the proliferation of esophageal carcinoma cells.Mol Med Rep2014 JunWang YQdoi: 10.3892/mmr.2014.2071
17634553Abrogation of signal transducer and activator of transcription 3 reactivation after Src kinase inhibition results in synergistic antitumor effects.Clin Cancer Res2007 Jul 15Johnson FM-
15665295Implication of STAT3 signaling in human colonic cancer cells during intestinal trefoil factor 3 (TFF3) -- and vascular endothelial growth factor-mediated cellular invasion and tumor growth.Cancer Res2005 Jan 1Rivat C-
21633165The JAK2/STAT3 signaling pathway is required for growth of CD44CD24 stem cell-like breast cancer cells in human tumors.J Clin Invest2011 JulMarotta LLdoi: 10.1172/JCI44745.
22484976Phosphorylation of signal transducer and activator of transcription 3 (STAT3) correlates with Her-2 status, carbonic anhydrase 9 expression and prognosis in esophageal cancer.Clin Exp Metastasis2012 AugSchoppmann SFdoi: 10.1007/s10585-012-9475-3
18644974Signal transducer and activator of transcription 3 is required for hypoxia-inducible factor-1alpha RNA expression in both tumor cells and tumor-associated myeloid cells.Mol Cancer Res2008 JulNiu Gdoi: 10.1158/1541-7786.MCR-07-2177.
21991388STAT3 knockdown reduces pancreatic cancer cell invasiveness and matrix metalloproteinase-7 expression in nude mice.PLoS One2011Li Hddoi: 10.1371/journal.pone.0025941
26323925Expression of signal transducer and activator of transcription 3 in breast cancer and its clinical significance.J Cancer Res Ther2015 AugWei Gdoi: 10.4103/0973-1482.163840.
26907764The prognostic significance of STAT3 in invasive breast cancer: analysis of protein and mRNA expressions in large cohorts.Breast Cancer Res Treat2016 FebAleskandarany MAdoi: 10.1007/s10549-016-3709-z
21994466Cytokine induction of tumor necrosis factor receptor 2 is mediated by STAT3 in colon cancer cells.Mol Cancer Res2011 DecHamilton KEdoi: 10.1158/1541-7786.MCR-10-0210
26130650IL6/JAK1/STAT3 Signaling Blockade in Endometrial Cancer Affects the ALDHhi/CD126+ Stem-like Component and Reduces Tumor Burden.Cancer Res2015 Sep 1van der Zee Mdoi: 10.1158/0008-5472.CAN-14-2498
22891351STAT3 negatively regulates thyroid tumorigenesis.Proc Natl Acad Sci U S A2012 Aug 28Couto JPdoi: 10.1073/pnas.1201232109
26875895MiR-874 inhibits cell growth and induces apoptosis by targeting STAT3 in human colorectal cancer cells.Eur Rev Med Pharmacol Sci2016Zhao B-
16948814Phospho-Stat3 expression and correlation with VEGF, p53, and Bcl-2 in gastric carcinoma using tissue microarray.APMIS2006 SepChoi JH-
11809683Modulation of signal transducer and activator of transcription 3 activities by p53 tumor suppressor in breast cancer cells.Cancer Res2002 Jan 15Lin J-
24696730STAT3 activation in tumor cell-free lymph nodes predicts a poor prognosis for gastric cancer.Int J Clin Exp Pathol2014 Feb 15Wu LJ-
25928665STAT3 is involved in miR-124-mediated suppressive effects on esophageal cancer cells.BMC Cancer2015 Apr 19Cheng Ydoi: 10.1186/s12885-015-1303-0.
25531908The tumor suppressor miR-124 inhibits cell proliferation by targeting STAT3 and functions as a prognostic marker for postoperative NSCLC patients.Int J Oncol2015 FebLi Xdoi: 10.3892/ijo.2014.2786
21333372JAK2/STAT3 signaling pathway activation mediates tumor angiogenesis by upregulation of VEGF and bFGF in non-small-cell lung cancer.Lung Cancer2011 SepZhao Mdoi: 10.1016/j.lungcan.2011.01.002
18535750Knockdown of STAT3 by shRNA inhibits the growth of CAOV3 ovarian cancer cell line in vitro and in vivo.Acta Biochim Biophys Sin (Shanghai)2008 JunHuang F-
17341611Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution.Ann N Y Acad Sci2006 DecAggarwal BB-
20860602Involvement of M2-polarized macrophages in the ascites from advanced epithelial ovarian carcinoma in tumor progression via Stat3 activation.Cancer Sci2010 OctTakaishi Kdoi: 10.1111/j.1349-7006.2010.01652.x
24652403Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer.Cancer Immunol Immunother2014 MayPanni RZdoi: 10.1007/s00262-014-1527-x
15735720Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity.Oncogene2005 May 5Sun J-
27819670HSP110 promotes colorectal cancer growth through STAT3 activation.Oncogene2017 Apr 20Berthenet Kdoi: 10.1038/onc.2016.403
28130110TNF-α-inducing protein of Helicobacter pylori induces epithelial-mesenchymal transition (EMT) in gastric cancer cells through activation of IL-6/STAT3 signaling pathway.Biochem Biophys Res Commun2017 Mar 4Chen Gdoi: 10.1016/j.bbrc.2017.01.110
27186677MicroRNA-544 down-regulates both Bcl6 and Stat3 to inhibit tumor growth of human triple negative breast cancer.Biol Chem2016 Oct 1Zhu Zdoi: 10.1515/hsz-2016-0104.
27875549The Synthetic β-Nitrostyrene Derivative CYT-Rx20 Inhibits Esophageal Tumor Growth and Metastasis via PI3K/AKT and STAT3 Pathways.PLoS One2016 Nov 22Chiu WCdoi: 10.1371/journal.pone.0166453
27292260Elevated STAT3 expression in ovarian cancer ascites promotes invasion and metastasis: a potential therapeutic target.Oncogene2017 Jan 12Saini Udoi: 10.1038/onc.2016.197
27419630Gallic acid inhibition of Src-Stat3 signaling overcomes acquired resistance to EGF receptor tyrosine kinase inhibitors in advanced non-small cell lung cancer.Oncotarget2016 Aug 23Phan ANdoi: 10.18632/oncotarget.10581.
29432737Activated STAT3 may participate in tumor progression through increasing CD133/survivin expression in early stage of colon cancer.Biochem Biophys Res Commun2018 Feb 26Li Wdoi: 10.1016/j.bbrc.2018.02.084
28830450MicroRNA-218 functions as a tumor suppressor in lung cancer by targeting IL-6/STAT3 and negatively correlates with poor prognosis.Mol Cancer2017 Aug 22Yang Ydoi: 10.1186/s12943-017-0710-z.
27306323Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells.Nat Commun2016 Jun 16Liu CCdoi: 10.1038/ncomms11798.
28240233Low-dose radiation decreases tumor progression via the inhibition of the JAK1/STAT3 signaling axis in breast cancer cell lines.Sci Rep2017 Feb 27Kaushik Ndoi: 10.1038/srep43361.
30305729Leukemia inhibitory factor functions in parallel with interleukin-6 to promote ovarian cancer growth.Oncogene2019 FebMcLean Kdoi: 10.1038/s41388-018-0523-6
24395800Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer.Proc Natl Acad Sci U S A2014 Jan 21Lui VWdoi: 10.1073/pnas.1319551111
16503733STAT3 as a therapeutic target in head and neck cancer.Expert Opin Biol Ther2006 MarLeeman RJ-
24025152Inhibiting signal transducer and activator of transcription-3 increases response to gemcitabine and delays progression of pancreatic cancer.Mol Cancer2013 Sep 11Venkatasubbarao Kdoi: 10.1186/1476-4598-12-104.
19273247The dark and the bright side of Stat3: proto-oncogene and tumor-suppressor.Front Biosci (Landmark Ed)2009 Jan 1Ecker A-
24886434Inhibition of the JAK2/STAT3 pathway in ovarian cancer results in the loss of cancer stem cell-like characteristics and a reduced tumor burden.BMC Cancer2014 May 6Abubaker Kdoi: 10.1186/1471-2407-14-317.
2555636914-3-3?? regulates immune response through Stat3 signaling in oral squamous cell carcinoma.Mol Cells2015Han Xdoi: 10.14348/molcells.2015.2101
19601808STAT3 regulation of glioblastoma pathogenesis.Curr Mol Med2009 Junde la Iglesia N-
22082308The expression and clinical significance of pSTAT3, VEGF and VEGF-C in pancreatic adenocarcinoma.Neoplasma2012Huang Cdoi: 10.4149/neo_2012_007.
24892807CTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cells.J Clin Invest2014 JulHerrmann Adoi: 10.1172/JCI73174
21502401A requirement of STAT3 DNA binding precludes Th-1 immunostimulatory gene expression by NF-??B in tumors.Cancer Res2011 Jun 1Lee Hdoi: 10.1158/0008-5472.CAN-10-3304
22480875Down regulation of CD24 and HER-2/neu in breast carcinoma cells by activated human dendritic cell. Role of STAT3.Cell Immunol2012 Jan-FebHira SKdoi: 10.1016/j.cellimm.2012.02.015
26397387Curcumin suppresses stem-like traits of lung cancer cells via inhibiting the JAK2/STAT3 signaling pathway.Oncol Rep2015 DecWu Ldoi: 10.3892/or.2015.4279
28230855Simvastatin-induced cell cycle arrest through inhibition of STAT3/SKP2 axis and activation of AMPK to promote p27 and p21 accumulation in hepatocellular carcinoma cells.Cell Death Dis2017 Feb 23Wang STdoi: 10.1038/cddis.2016.472.
28089821The role of STAT3 in glioblastoma progression through dual influences on tumor cells and the immune microenvironment.Mol Cell Endocrinol2017 Aug 15Chang Ndoi: 10.1016/j.mce.2017.01.004
28088463Stress-induced EGF receptor signaling through STAT3 and tumor progression in triple-negative breast cancer.Mol Cell Endocrinol2017 Aug 15Balanis Ndoi: 10.1016/j.mce.2017.01.013
25833823STAT3 and HIF1α Signaling Drives Oncogenic Cellular Phenotypes in Malignant Peripheral Nerve Sheath Tumors.Mol Cancer Res2015 JulRad Edoi: 10.1158/1541-7786.MCR-14-0182
25681443Oncovirus Kaposi sarcoma herpesvirus (KSHV) represses tumor suppressor PDLIM2 to persistently activate nuclear factor ??B (NF-??B) and STAT3 transcription factors for tumorigenesis and tumor maintenance.J Biol Chem2015 Mar 20Sun Fdoi: 10.1074/jbc.C115.637918
17194701Expression of constitutively active STAT3 can replicate the cytokine-suppressive activity of interleukin-10 in human primary macrophages.J Biol Chem2007 Mar 9Williams LM-
19070595Serpin B3/B4, activated by STAT3, promote survival of squamous carcinoma cells.Biochem Biophys Res Commun2009 Jan 23Ahmed STdoi: 10.1016/j.bbrc.2008.11.147
22521547DNA damage induces the IL-6/STAT3 signaling pathway, which has anti-senescence and growth-promoting functions in human tumors.Cancer Lett2012 Oct 28Yun UJdoi: 10.1016/j.canlet.2012.04.003
24211205MicroRNA-124 suppresses growth of human hepatocellular carcinoma by targeting STAT3.Biochem Biophys Res Commun2013 Nov 29Lu Ydoi: 10.1016/j.bbrc.2013.10.157
23807222Salinomycin induces cell death via inactivation of Stat3 and downregulation of Skp2.Cell Death Dis2013 Jun 27Koo KHdoi: 10.1038/cddis.2013.223.
19789299All-trans retinoic acid suppresses Stat3 signaling during skin carcinogenesis.Cancer Prev Res (Phila)2009 OctSyed Zdoi: 10.1158/1940-6207.CAPR-09-0041
16061651A Ras homologue member I directly inhibits signal transducers and activators of transcription 3 translocation and activity in human breast and ovarian cancer cells.Cancer Res2005 Aug 1Nishimoto A-
17209045Ras/ERK1/2-mediated STAT3 Ser727 phosphorylation by familial medullary thyroid carcinoma-associated RET mutants induces full activation of STAT3 and is required for c-fos promoter activation, cell mitogenicity, and transformation.J Biol Chem2007 Mar 2Plaza-Menacho I-
23386605Tumor-derived mutations in the gene associated with retinoid interferon-induced mortality (GRIM-19) disrupt its anti-signal transducer and activator of transcription 3 (STAT3) activity and promote oncogenesis.J Biol Chem2013 Mar 15Nallar SCdoi: 10.1074/jbc.M112.440610
21481787Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression.Cancer Cell2011 Apr 12Fukuda Adoi: 10.1016/j.ccr.2011.03.002.
22547799Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation.Proc Natl Acad Sci U S A2012 May 15Lee Hdoi: 10.1073/pnas.1205132109
23364389Tumor-associated macrophage promotes tumor progression via STAT3 signaling in hepatocellular carcinoma.Pathobiology2013Mano Ydoi: 10.1159/000346196
26631279Multiple regulation pathways and pivotal biological functions of STAT3 in cancer.Sci Rep2015 Dec 3Yuan Jdoi: 10.1038/srep17663.
15064716Bacterial N-acylhomoserine lactone-induced apoptosis in breast carcinoma cells correlated with down-modulation of STAT3.Oncogene2004 Jun 17Li L-
16107692Role of Stat3 in regulating p53 expression and function.Mol Cell Biol2005 SepNiu G-
22488042The expression of p-STAT3 in stage IV melanoma: risk of CNS metastasis and survival.Oncotarget2012 MarLee I-
26927669Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy.J Clin Invest2016 Apr 1Lee Ddoi: 10.1172/JCI84620
19843641A novel oncolytic adenovirus selectively silences the expression of tumor-associated STAT3 and exhibits potent antitumoral activity.Carcinogenesis2009 DecHan Zdoi: 10.1093/carcin/bgp249.
23920124Guggulsterone decreases proliferation and metastatic behavior of pancreatic cancer cells by modulating JAK/STAT and Src/FAK signaling.Cancer Lett2013 Dec 1Macha MAdoi: 10.1016/j.canlet.2013.07.037
23454751STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients.J Clin Invest2013 AprVasquez-Dunddel D-
23590999STAT3 expression correlates with prognosis of thymic epithelial tumors.J Cardiothorac Surg2013 Apr 16Li Cdoi: 10.1186/1749-8090-8-92.
22260073[Clinical significance of Stat3 and Cyclin D1 expression in laryngeal squamous cell carcinoma].Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi2011 NovWang L-
28011380Propofol enhances the cisplatin-induced apoptosis on cervical cancer cells via EGFR/JAK2/STAT3 pathway.Biomed Pharmacother2017 FebLi Hdoi: 10.1016/j.biopha.2016.12.036
21674558Interleukin-22 promotes human hepatocellular carcinoma by activation of STAT3.Hepatology2011 Sep 2Jiang Rdoi: 10.1002/hep.24486
22745305S1PR1 is an effective target to block STAT3 signaling in activated B cell-like diffuse large B-cell lymphoma.Blood2012 Aug 16Liu Ydoi: 10.1182/blood-2011-12-399030
26244872Jak3, STAT3, and STAT5 inhibit expression of miR-22, a novel tumor suppressor microRNA, in cutaneous T-Cell lymphoma.Oncotarget2015 Aug 21Sibbesen NA-
20473906STAT3 is essential for the maintenance of neurosphere-initiating tumor cells in patients with glioblastomas: a potential for targeted therapy?Int J Cancer2011 Feb 15Villalva Cdoi: 10.1002/ijc.25416.
26921327Resistance to Anti-VEGF Therapy Mediated by Autocrine IL6/STAT3 Signaling and Overcome by IL6 Blockade.Cancer Res2016 Apr 15Eichten Adoi: 10.1158/0008-5472.CAN-15-1443
23416975PTTG acts as a STAT3 target gene for colorectal cancer cell growth and motility.Oncogene2014 Feb 13Zhou Cdoi: 10.1038/onc.2013.16
25572805Increased drug resistance in breast cancer by tumor-associated macrophages through IL-10/STAT3/bcl-2 signaling pathway.Med Oncol2015 FebYang Cdoi: 10.1007/s12032-014-0352-6
23838996Antiangiogenic effects of ganetespib in colorectal cancer mediated through inhibition of HIF-1α and STAT-3.Angiogenesis2013 OctNagaraju GPdoi: 10.1007/s10456-013-9364-7
23693134Variant G6PD levels promote tumor cell proliferation or apoptosis via the STAT3/5 pathway in the human melanoma xenograft mouse model.BMC Cancer2013 May 22Hu Tdoi: 10.1186/1471-2407-13-251.
19601811STAT3 as a central regulator of tumor metastases.Curr Mol Med2009 JunDevarajan E-
25954856Oncostatin M activates STAT3 to promote endometrial cancer invasion and angiogenesis.Oncol Rep2015 JulZhu Mdoi: 10.3892/or.2015.3951
25031744Concurrent CD44s and STAT3 expression in human clear cell renal cellular carcinoma and its impact on survival.Int J Clin Exp Pathol2014 May 15Qin J-
15923602Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cells.Mol Cell Biol2005 JunProietti C-
15141228In vivo activation of STAT3 in cutaneous T-cell lymphoma. Evidence for an antiapoptotic function of STAT3.Leukemia2004 JulSommer VH-
19642906Down-regulation of GRIM-19 expression is associated with hyperactivation of STAT3-induced gene expression and tumor growth in human cervical cancers.J Interferon Cytokine Res2009 OctZhou Ydoi: 10.1089/jir.2009.0003.
15034082Recruitment of STAT3 for production of IL-10 by colon carcinoma cells induced by macrophage-derived IL-6.J Immunol2004 Apr 1Herbeuval JP-
25893308IGFBP2 potentiates nuclear EGFR-STAT3 signaling.Oncogene2016 Feb 11Chua CYdoi: 10.1038/onc.2015.131
25476455Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3 activity and suppresses gliomas tumorigenicity.Sci Rep2014 Dec 5Kim HSdoi: 10.1038/srep07330.
26743134High glucose enhances progression of cholangiocarcinoma cells via STAT3 activation.Sci Rep2016 Jan 8Saengboonmee Cdoi: 10.1038/srep18995.
16061629Signal transducer and activator of transcription 3 (STAT3) regulates human telomerase reverse transcriptase (hTERT) expression in human cancer and primary cells.Cancer Res2005 Aug 1Konnikova L-
26565811Loss of function mutations in PTPN6 promote STAT3 deregulation via JAK3 kinase in diffuse large B-cell lymphoma.Oncotarget2015 Dec 29Demosthenous Cdoi: 10.18632/oncotarget.6300.
25239565miR-17-92 cluster promotes cholangiocarcinoma growth: evidence for PTEN as downstream target and IL-6/Stat3 as upstream activator.Am J Pathol2014 OctZhu Hdoi: 10.1016/j.ajpath.2014.06.024.
15917293Stat3 is required for full neoplastic transformation by the Simian Virus 40 large tumor antigen.Mol Biol Cell2005 AugVultur A-
24386409Inhibition of STAT3 reduces astrocytoma cell invasion and constitutive activation of STAT3 predicts poor prognosis in human astrocytoma.PLoS One2013 Dec 30Liang Qdoi: 10.1371/journal.pone.0084723
26646273Blockage of STAT3 Signaling Pathway by Morusin Induces Apoptosis and Inhibits Invasion in Human Pancreatic Tumor Cells.Pancreas2016 MarKim Cdoi: 10.1097/MPA.0000000000000496.
17015686A preferential role for STAT5, not constitutively active STAT3, in promoting survival of a human lymphoid tumor.J Immunol2006 Oct 15Nagy ZS-
24029664Supraglottic laryngeal tumor microenvironmental factors facilitate STAT3 dependent pro-tumorigenic switch in tumor associated macrophages to render utmost immune evasion.Immunol Lett2013 Nov-DecGoswami KKdoi: 10.1016/j.imlet.2013.09.003
22319590STAT3 is activated by JAK2 independent of key oncogenic driver mutations in non-small cell lung carcinoma.PLoS One2012Looyenga BDdoi: 10.1371/journal.pone.0030820
24476004Loss of suppressors of cytokine signaling 3 promotes aggressiveness in hepatocellular carcinoma.J Invest Surg2014 AugWu WYdoi: 10.3109/08941939.2013.873098
23526220Metformin enhances cisplatin cytotoxicity by suppressing signal transducer and activator of transcription-3 activity independently of the liver kinase B1-AMP-activated protein kinase pathway.Am J Respir Cell Mol Biol2013 AugLin CCdoi: 10.1165/rcmb.2012-0244OC.
25787299JSI-124 (Cucurbitacin I) inhibits tumor angiogenesis of human breast cancer through reduction of STAT3 phosphorylation.Am J Chin Med2015Qi Jdoi: 10.1142/S0192415X15500226
26389681MiR-125a suppresses tumor growth, invasion and metastasis in cervical cancer by targeting STAT3.Oncotarget2015 Sep 22Fan Zdoi: 10.18632/oncotarget.4457.
26405196The Opposing Function of STAT3 as an Oncoprotein and Tumor Suppressor Is Dictated by the Expression Status of STAT3β in Esophageal Squamous Cell Carcinoma.Clin Cancer Res2016 Feb 1Zhang HFdoi: 10.1158/1078-0432.CCR-15-1253
21726833CD24(+) liver tumor-initiating cells drive self-renewal and tumor initiation through STAT3-mediated NANOG regulation.Cell Stem Cell2011 Jul 8Lee TKdoi: 10.1016/j.stem.2011.06.005.
26314961STAT3 pathway regulates lung-derived brain metastasis initiating cell capacity through miR-21 activation.Oncotarget2015 Sep 29Singh Mdoi: 10.18632/oncotarget.4742.
27461244miR-451 acts as a suppressor of angiogenesis in hepatocellular carcinoma by targeting the IL-6R-STAT3 pathway.Oncol Rep2016 SepLiu Xdoi: 10.3892/or.2016.4971
23734190B cells promote tumor progression via STAT3 regulated-angiogenesis.PLoS One2013 May 29Yang Cdoi: 10.1371/journal.pone.0064159
25881542Stat3 orchestrates interaction between endothelial and tumor cells and inhibition of Stat3 suppresses brain metastasis of breast cancer cells.Oncotarget2015 Apr 30Lee HT-
12193474STAT3 activation abrogates growth factor dependence and contributes to head and neck squamous cell carcinoma tumor growth in vivo.Cell Growth Differ2002 AugKijima T-
26844481Prognostic Value and Clinicopathological Significance of p-stat3 Among Gastric Carcinoma Patients: A Systematic Review and Meta-Analysis.Medicine (Baltimore)2016 FebJi Kdoi: 10.1097/MD.0000000000002641.
24843164Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis.Proc Natl Acad Sci U S A2014 Jun 3Ortiz Bdoi: 10.1073/pnas.1401952111
23333300Stat3 inhibits WTX expression through up-regulation of microRNA-370 in Wilms tumor.FEBS Lett2013 Mar 18Cao Xdoi: 10.1016/j.febslet.2013.01.012
25550842Dual high expression of STAT3 and cyclinD1 is associated with poor prognosis after curative resection of esophageal squamous cell carcinoma.Int J Clin Exp Pathol2014 Oct 15Li H-
17824789Expression of activated and latent signal transducer and activator of transcription 3 in 303 non-small cell lung carcinomas and 44 malignant mesotheliomas: possible role for chemotherapeutic intervention.Arch Pathol Lab Med2007 SepAchcar Rde O-
22194466Metastatic cells can escape the proapoptotic effects of TNF-α through increased autocrine IL-6/STAT3 signaling.Cancer Res2012 Feb 15Li Sdoi: 10.1158/0008-5472.CAN-11-1357
25968456Interleukin-6/STAT3 Pathway Signaling Drives an Inflammatory Phenotype in Group A Ependymoma.Cancer Immunol Res2015 OctGriesinger AMdoi: 10.1158/2326-6066.CIR-15-0061
11960372Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis.Oncogene2002 Mar 27Niu G-
23288901STAT3 suppresses transcription of proapoptotic genes in cancer cells with the involvement of its N-terminal domain.Proc Natl Acad Sci U S A2013 Jan 22Timofeeva OAdoi: 10.1073/pnas.1211805110
22303479Piwil2 suppresses p53 by inducing phosphorylation of signal transducer and activator of transcription 3 in tumor cells.PLoS One2012Lu Ydoi: 10.1371/journal.pone.0030999
23378274Abrogation of galectin-4 expression promotes tumorigenesis in colorectal cancer.Cell Oncol (Dordr)2013 AprKim SWdoi: 10.1007/s13402-013-0124-x
24966947EGCG inhibits the growth and tumorigenicity of nasopharyngeal tumor-initiating cells through attenuation of STAT3 activation.Int J Clin Exp Pathol2014 Apr 15Lin CH-
22467101Expression and prognostic relevance of STAT3 and cyclin D1 in non-small cell lung cancer.Int J Biol Markers2012 Jul 19Ai Tdoi: 10.5301/JBM.2012.9146.
19278424Concordant overexpression of phosphorylated ATF2 and STAT3 in extramammary Paget's disease.J Cutan Pathol2009 AprChen SYdoi: 10.1111/j.1600-0560.2008.01076.x.
19484147Cross talk initiated by endothelial cells enhances migration and inhibits anoikis of squamous cell carcinoma cells through STAT3/Akt/ERK signaling.Neoplasia2009 JunNeiva KG-
16036105Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth.Neoplasia2005 JunCorvinus FM-
24027425STAT3 in epithelial cells regulates inflammation and tumor progression to malignant state in colon.Neoplasia2013 SepNguyen AV-
18577706STAT3- and STAT5-dependent pathways competitively regulate the pan-differentiation of CD34pos cells into tumor-competent dendritic cells.Blood2008 Sep 1Cohen PAdoi: 10.1182/blood-2007-12-130138
23665320The expression of IL-6 and STAT3 might predict progression and unfavorable prognosis in Wilms' tumor.Biochem Biophys Res Commun2013 Jun 7Zhang LJdoi: 10.1016/j.bbrc.2013.04.102
24116074Activation of STAT3 in human gastric cancer cells via interleukin (IL)-6-type cytokine signaling correlates with clinical implications.PLoS One2013 Oct 7Wang Zdoi: 10.1371/journal.pone.0075788
22147524Turmeric (Curcuma longa) inhibits inflammatory nuclear factor (NF)-??B and NF-??B-regulated gene products and induces death receptors leading to suppressed proliferation, induced chemosensitization, and suppressed osteoclastogenesis.Mol Nutr Food Res2012 MarKim JHdoi: 10.1002/mnfr.201100270
20053726Sunitinib induces apoptosis and growth arrest of medulloblastoma tumor cells by inhibiting STAT3 and AKT signaling pathways.Mol Cancer Res2010 JanYang Fdoi: 10.1158/1541-7786.MCR-09-0220
17460772Signal transducer and activator of transcription 3 activation promotes invasive growth of colon carcinomas through matrix metalloproteinase induction.Neoplasia2007 AprTsareva SA-
22154363EGFR, HER2, survivin, and loss of pSTAT3 characterize high-grade malignancy in salivary gland cancer with impact on prognosis.Hum Pathol2012 JunEttl Tdoi: 10.1016/j.humpath.2011.08.006
27498908miR-124 inhibits proliferation and invasion of human retinoblastoma cells by targeting STAT3.Oncol Rep2016 OctLiu Sdoi: 10.3892/or.2016.4999
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18441325Hyaluronan-CD44 interaction activates stem cell marker Nanog, Stat-3-mediated MDR1 gene expression, and ankyrin-regulated multidrug efflux in breast and ovarian tumor cells.J Biol Chem2008 Jun 20Bourguignon LYdoi: 10.1074/jbc.M800109200
28000897Bortezomib induces apoptosis and suppresses cell growth and metastasis by inactivation of Stat3 signaling in chondrosarcoma.Int J Oncol2017 FebBao Xdoi: 10.3892/ijo.2016.3806
27878304Upregulation of MEK5 by Stat3 promotes breast cancer cell invasion and metastasis.Oncol Rep2017 JanLiu Fdoi: 10.3892/or.2016.5256
28631574MicroRNA-125a-5p plays a role as a tumor suppressor in lung carcinoma cells by directly targeting STAT3.Tumour Biol2017 JunZhong Ldoi: 10.1177/1010428317697579.
26616859STAT3 selectively interacts with Smad3 to antagonize TGF-β signalling.Oncogene2016 Aug 18Wang Gdoi: 10.1038/onc.2015.446
26853466HDAC7 inhibition resets STAT3 tumorigenic activity in human glioblastoma independently of EGFR and PTEN: new opportunities for selected targeted therapies.Oncogene2016 Aug 25Peixoto Pdoi: 10.1038/onc.2015.506
28055016Inhibition of Stat3 signaling pathway by nifuroxazide improves antitumor immunity and impairs colorectal carcinoma metastasis.Cell Death Dis2017 Jan 5Ye THdoi: 10.1038/cddis.2016.452.
28828629Interleukin 6 induces M2 macrophage differentiation by STAT3 activation that correlates with gastric cancer progression.Cancer Immunol Immunother2017 DecFu XLdoi: 10.1007/s00262-017-2052-5
28121485MIR506 induces autophagy-related cell death in pancreatic cancer cells by targeting the STAT3 pathway.Autophagy2017 Apr 3Sun Ldoi: 10.1080/15548627.2017.1280217
29074425The membrane bile acid receptor TGR5 drives cell growth and migration via activation of the JAK2/STAT3 signaling pathway innon-small cell lung cancer.Cancer Lett2018 Jan 1Liu Xdoi: 10.1016/j.canlet.2017.10.017
27145366BRG1 targeting STAT3/VEGFC signaling regulates lymphangiogenesis in colorectal cancer.Oncotarget2016 Jun 14Zhu Xdoi: 10.18632/oncotarget.9038.
28030813Stattic and metformin inhibit brain tumor initiating cells by reducing STAT3-phosphorylation.Oncotarget2017 Jan 31Leidgens Vdoi: 10.18632/oncotarget.14159.
28088467STAT3 signaling mediates tumour resistance to EGFR targeted therapeutics.Mol Cell Endocrinol2017 Aug 15Zulkifli AAdoi: 10.1016/j.mce.2017.01.010
28053020Blocking Tumor-Educated MSC Paracrine Activity Halts Osteosarcoma Progression.Clin Cancer Res2017 Jul 15Baglio SRdoi: 10.1158/1078-0432.CCR-16-2726
28489571Analysis of STAT3 post-translational modifications (PTMs) in human prostate cancer with different Gleason Score.Oncotarget2017 Jun 27Cocchiola Rdoi: 10.18632/oncotarget.17245.
29516928Cyclin D1 overexpression associated with activation of STAT3 in oral carcinoma patients from South India.J Cancer Res Ther2018 Jan-MarDeepak Roshan VGdoi: 10.4103/0973-1482.188295.
27553854LncSox4 promotes the self-renewal of liver tumour-initiating cells through Stat3-mediated Sox4 expression.Nat Commun2016 Aug 24Chen ZZdoi: 10.1038/ncomms12598.
29507229Myeloid ERK5 deficiency suppresses tumor growth by blocking protumor macrophage polarization via STAT3 inhibition.Proc Natl Acad Sci U S A2018 Mar 20Giurisato Edoi: 10.1073/pnas.1707929115
29901083CXCR7 silencing inhibits the migration and invasion of human tumor endothelial cells derived from hepatocellular carcinoma by suppressing STAT3.Mol Med Rep2018 AugWu Ydoi: 10.3892/mmr.2018.9114
29957468Fatty acid binding protein 5 promotes tumor angiogenesis and activates the IL6/STAT3/VEGFA pathway in hepatocellular carcinoma.Biomed Pharmacother2018 OctPan Ldoi: 10.1016/j.biopha.2018.06.040
29288042STAT3 mutation and its clinical and histopathologic correlation in T-cell large granular lymphocytic leukemia.Hum Pathol2018 MarShi Mdoi: 10.1016/j.humpath.2017.12.014
30375073HMGB1 knock-down promoting tumor cells viability and arrest pro-apoptotic proteins via Stat3/NF??B in HepG2 cells.Biofactors2018 NovAlduais Sdoi: 10.1002/biof.1456
29164994STAT3 inhibition as a therapeutic strategy for leukemia.Leuk Lymphoma2018 SepKanna Rdoi: 10.1080/10428194.2017.1397668
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24435707A ROS/STAT3/HIF-1α signaling cascade mediates EGF-induced TWIST1 expression and prostate cancer cell invasion.Prostate2014 MayCho KHdoi: 10.1002/pros.22776
24946088The IL-6-STAT3 axis mediates a reciprocal crosstalk between cancer-derived mesenchymal stem cells and neutrophils to synergistically prompt gastric cancer progression.Cell Death Dis2014 Jun 19Zhu Qdoi: 10.1038/cddis.2014.263.
16951221Signal transducers and activators of transcription 3 pathway activation in drug-resistant ovarian cancer.Clin Cancer Res2006 Sep 1Duan Z-
24122993Ursolic acid inhibits the growth of colon cancer-initiating cells by targeting STAT3.Anticancer Res2013 OctWang W-
25405516Ginsenoside 20(S)Rg3 inhibits the Warburg effect through STAT3 pathways in ovarian cancer cells.Int J Oncol2015 FebLi Jdoi: 10.3892/ijo.2014.2767
18483213Stat3 promotes metastatic progression of prostate cancer.Am J Pathol2008 JunAbdulghani Jdoi: 10.2353/ajpath.2008.071054
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26840943IGF/STAT3/NANOG/Slug Signaling Axis Simultaneously Controls Epithelial-Mesenchymal Transition and Stemness Maintenance in Colorectal Cancer.Stem Cells2016 AprYao Cdoi: 10.1002/stem.2320
26559373Constitutive activation of STAT3 in breast cancer cells: A review.Int J Cancer2016 Jun 1Banerjee Kdoi: 10.1002/ijc.29923
26124007BMP-2 induces motility and invasiveness by promoting colon cancer stemness through STAT3 activation.Tumour Biol2015 DecKim BRdoi: 10.1007/s13277-015-3681-y
26965998Jak-STAT3 pathway triggers DICER1 for proteasomal degradation by ubiquitin ligase complex of CUL4A(DCAF1) to promote colon cancer development.Cancer Lett2016 Jun 1Ren Wdoi: 10.1016/j.canlet.2016.02.055
17459060RNA interference-mediated signal transducers and activators of transcription 3 gene silencing inhibits invasion and metastasis of human pancreatic cancer cells.Cancer Sci2007 JulQiu Z-
26582900AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer.Sci Transl Med2015 Nov 18Hong Ddoi: 10.1126/scitranslmed.aac5272.
27052330Targeting HCCR expression resensitizes gastric cancer cells to chemotherapy via down-regulating the activation of STAT3.Sci Rep2016 Apr 7Zhang JLdoi: 10.1038/srep24196.
28466782Tumor protein D52 (isoform 3) contributes to prostate cancer cell growth via targeting nuclear factor-??B transactivation in LNCaP cells.Tumour Biol2017 MayDasari Cdoi: 10.1177/1010428317698382.
28475004Knockdown of long non-coding RNA HOXD-AS1 inhibits gastric cancer cell growth via inactivating the JAK2/STAT3 pathway.Tumour Biol2017 MayZheng Ldoi: 10.1177/1010428317705335.
28711499Inhibition of IL-6/STAT3 signaling in human cancer cells using Evista.Biochem Biophys Res Commun2017 Sep 9Shi Wdoi: 10.1016/j.bbrc.2017.07.067
28795470Dermokine contributes to epithelial-mesenchymal transition through increased activation of signal transducer and activator of transcription 3 in pancreatic cancer.Cancer Sci2017 NovHuang Cdoi: 10.1111/cas.13347
27297362IL-6/STAT3 axis initiated CAFs via up-regulating TIMP-1 which was attenuated by acetylation of STAT3 induced by PCAF in HCC microenvironment.Cell Signal2016 SepZheng Xdoi: 10.1016/j.cellsig.2016.06.009
27167343Mitochondrial GRIM-19 as a potential therapeutic target for STAT3-dependent carcinogenesis of gastric cancer.Oncotarget2016 Jul 5Huang Ydoi: 10.18632/oncotarget.9167.
28498395MicroRNA-1299 is a negative regulator of STAT3 in colon cancer.Oncol Rep2017 JunWang Ydoi: 10.3892/or.2017.5605
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28849140STAT3 inhibition by WP1066 suppresses the growth and invasiveness of bladder cancer cells.Oncol Rep2017 OctTsujita Ydoi: 10.3892/or.2017.5902
29655056IL-17 inhibits the accumulation of myeloid-derived suppressor cells in breast cancer via activating STAT3.Int Immunopharmacol2018 JunMa Mdoi: 10.1016/j.intimp.2018.04.013
30068339STAT3 exacerbates survival of cancer stem-like tumorspheres in EGFR-positive colorectal cancers: RNAseq analysis and therapeutic screening.J Biomed Sci2018 Aug 2Cheng CCdoi: 10.1186/s12929-018-0456-y.
29249663HN1L Promotes Triple-Negative Breast Cancer Stem Cells through LEPR-STAT3 Pathway.Stem Cell Reports2018 Jan 9Liu Ydoi: 10.1016/j.stemcr.2017.11.010
30061175STAT3 regulated miR-216a promotes ovarian cancer proliferation and cisplatin resistance.Biosci Rep2018 Aug 29Jin Pdoi: 10.1042/BSR20180547
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23756862Both STAT1 and STAT3 are favourable prognostic determinants in colorectal carcinoma.Br J Cancer2013 Jul 9Gordziel Cdoi: 10.1038/bjc.2013.274
26041409Src/STAT3-dependent heme oxygenase-1 induction mediates chemoresistance of breast cancer cells to doxorubicin by promoting autophagy.Cancer Sci2015 AugTan Qdoi: 10.1111/cas.12712
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22350508STAT3 silencing enhances the efficacy of the HSV.tk suicide gene in gastrointestinal cancer therapy.Clin Exp Metastasis2012 AprAhn YHdoi: 10.1007/s10585-012-9458-4
25481644Sphingosine kinase 1 contributes to leptin-induced STAT3 phosphorylation through IL-6/gp130 transactivation in oestrogen receptor-negative breast cancer.Breast Cancer Res Treat2015 JanAlshaker Hdoi: 10.1007/s10549-014-3228-8
25967142TLR9-Targeted STAT3 Silencing Abrogates Immunosuppressive Activity of Myeloid-Derived Suppressor Cells from Prostate Cancer Patients.Clin Cancer Res2015 Aug 15Hossain DMdoi: 10.1158/1078-0432.CCR-14-3145
25544568Notch1 induces epithelial-mesenchymal transition and the cancer stem cell phenotype in breast cancer cells and STAT3 plays a key role.Int J Oncol2015 MarZhang Xdoi: 10.3892/ijo.2014.2809
23604529STAT3 acetylation-induced promoter methylation is associated with downregulation of the ARHI tumor-suppressor gene in ovarian cancer.Oncol Rep2013 JulLi Jdoi: 10.3892/or.2013.2414
25854163MRTF-A and STAT3 promote MDA-MB-231 cell migration via hypermethylating BRSM1.IUBMB Life2015 MarXing WJdoi: 10.1002/iub.1362
25234193Piperine inhibits IL-1β-induced IL-6 expression by suppressing p38 MAPK and STAT3 activation in gastric cancer cells.Mol Cell Biochem2015 JanXia Ydoi: 10.1007/s11010-014-2214-0
26682870Targeting the Janus-activated kinase-2-STAT3 signalling pathway in pancreatic cancer using the HSP90 inhibitor ganetespib.Eur J Cancer2016 JanNagaraju GPdoi: 10.1016/j.ejca.2015.10.057
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24472538Blockage of Stat3 enhances the sensitivity of NSCLC cells to PI3K/mTOR inhibition.Biochem Biophys Res Commun2014 Feb 21Jin HOdoi: 10.1016/j.bbrc.2014.01.086
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24864251rs744166 polymorphism of the STAT3 gene is associated with risk of gastric cancer in a Chinese population.Biomed Res Int2014Yuan Kdoi: 10.1155/2014/527918
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23704922IL-26 promotes the proliferation and survival of human gastric cancer cells by regulating the balance of STAT1 and STAT3 activation.PLoS One2013 May 21You Wdoi: 10.1371/journal.pone.0063588
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23124042GRIM-19 inhibits the STAT3 signaling pathway and sensitizes gastric cancer cells to radiation.Gene2013 Jan 10Bu Xdoi: 10.1016/j.gene.2012.10.057
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23094050APE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1-STAT3 dual-targeting effectively inhibits pancreatic cancer cell survival.PLoS One2012Cardoso AAdoi: 10.1371/journal.pone.0047462
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25231320Tunicamycin-induced ER stress regulates chemokine CCL5 expression and secretion via STAT3 followed by decreased transmigration of MCF-7 breast cancer cells.Oncol Rep2014 DecZhang Ydoi: 10.3892/or.2014.3479
26528725Salinomycin Promotes Anoikis and Decreases the CD44+/CD24- Stem-Like Population via Inhibition of STAT3 Activation in MDA-MB-231 Cells.PLoS One2015 Nov 3An Hdoi: 10.1371/journal.pone.0141919
25992623Fas Signaling Promotes Gastric Cancer Metastasis through STAT3-Dependent Upregulation of Fascin.PLoS One2015 May 18Yang Ydoi: 10.1371/journal.pone.0125132
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27101199EPHA3 regulates the multidrug resistance of small cell lung cancer via the PI3K/BMX/STAT3 signaling pathway.Tumour Biol2016 SepPeng J-
23650499Targeting mitochondrial STAT3 with the novel phospho-valproic acid (MDC-1112) inhibits pancreatic cancer growth in mice.PLoS One2013 May 1Mackenzie GGdoi: 10.1371/journal.pone.0061532
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25107644N6-substituted adenosine analogues, a novel class of JAK2 inhibitors, potently block STAT3 signaling in human cancer cells.Cancer Lett2014 Nov 1Liu Pdoi: 10.1016/j.canlet.2014.07.043
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25750173Aberrantly expressed Fra-1 by IL-6/STAT3 transactivation promotes colorectal cancer aggressiveness through epithelial-mesenchymal transition.Carcinogenesis2015 AprLiu Hdoi: 10.1093/carcin/bgv017
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17888401SOCS1 induced by NDRG2 expression negatively regulates STAT3 activation in breast cancer cells.Biochem Biophys Res Commun2007 Nov 16Park Y-
26151358B7H3 promotes cell migration and invasion through the Jak2/Stat3/MMP9 signaling pathway in colorectal cancer.Mol Med Rep2015 OctLiu Fdoi: 10.3892/mmr.2015.4050
23613996Stat3 downstream gene product chitinase 3-like 1 is a potential biomarker of inflammation-induced lung cancer in multiple mouse lung tumor models and humans.PLoS One2013 Apr 22Yan Cdoi: 10.1371/journal.pone.0061984
24533098RhoC regulates cancer stem cells in head and neck squamous cell carcinoma by overexpressing IL-6 and phosphorylation of STAT3.PLoS One2014 Feb 12Islam Mdoi: 10.1371/journal.pone.0088527
24307657Inhibition of constitutively active Stat3 reverses enzalutamide resistance in LNCaP derivative prostate cancer cells.Prostate2014 FebLiu Cdoi: 10.1002/pros.22741
25132422An analysis of genetic factors related to risk of inflammatory bowel disease and colon cancer.Cancer Epidemiol2014 OctRyan BMdoi: 10.1016/j.canep.2014.07.003
22532166Stat3 activation in urothelial stem cells leads to direct progression to invasive bladder cancer.Cancer Res2012 Jul 1Ho PLdoi: 10.1158/0008-5472.CAN-11-3195
19491198Reciprocal effects of STAT5 and STAT3 in breast cancer.Mol Cancer Res2009 JunWalker SRdoi: 10.1158/1541-7786.MCR-08-0238
25439778C-terminal tensin-like protein mediates invasion of human lung cancer cells and is regulated by signal transducer and activator oftranscription 3.J Thorac Cardiovasc Surg2015 JanBennett DTdoi: 10.1016/j.jtcvs.2014.08.087
25902005Ubiquitin-specific peptidase 22 inhibits colon cancer cell invasion by suppressing the signal transducer and activator of transcription 3/matrix metalloproteinase 9 pathway.Mol Med Rep2015 AugAo Ndoi: 10.3892/mmr.2015.3661
24642471IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis.J Clin Invest2014 AprRokavec Mdoi: 10.1172/JCI73531
21866460[(-)-Epigallocatechin-3-gallate reduces vascular endothelial growth factor expression in gastric cancer cells via suppressing activity].Zhonghua Wei Chang Wai Ke Za Zhi2011 AugZhu BH-
24055735Nitric oxide donors: spermine/NO and diethylenetriamine/NO induce ovarian cancer cell death and affect STAT3 and AKT signaling proteins.Nitric Oxide2013 Nov 30Kielbik Mdoi: 10.1016/j.niox.2013.09.001
25611565Quercetin induces endoplasmic reticulum stress to enhance cDDP cytotoxicity in ovarian cancer: involvement of STAT3 signaling.FEBS J2015 MarYang Zdoi: 10.1111/febs.13206
21430300Genetic polymorphisms in inflammation pathway genes and prostate cancer risk.Cancer Epidemiol Biomarkers Prev2011 MayKwon EMdoi: 10.1158/1055-9965.EPI-10-0994
25471787Overexpression of SMYD3 was associated with increased STAT3 activation in gastric cancer.Med Oncol2015 JanLiu Ydoi: 10.1007/s12032-014-0404-y
26676754Novel Morphologic and Genetic Analysis of Cancer Cells in a 3D Microenvironment Identifies STAT3 as a Regulator of Tumor Permeability Barrier Function.Cancer Res2016 Mar 1Park MCdoi: 10.1158/0008-5472.CAN-14-2611
24473196STAT3 induction of miR-146b forms a feedback loop to inhibit the NF-??B to IL-6 signaling axis and STAT3-driven cancer phenotypes.Sci Signal2014 Jan 28Xiang Mdoi: 10.1126/scisignal.2004497.
26781210Acquired resistance of pancreatic cancer cells to treatment with gemcitabine and HER-inhibitors is accompanied by increased sensitivity to STAT3 inhibition.Int J Oncol2016 MarIoannou Ndoi: 10.3892/ijo.2016.3320
24135245Signal transducers and activators of transcription 3 function in lung cancer.J Cancer Res Ther2013 SepLi CJ-
16278387Cyclooxygenase-2-dependent activation of signal transducer and activator of transcription 3 by interleukin-6 in non-small cell lung cancer.Clin Cancer Res2005 Nov 1Dalwadi H-
23824569STAT3 is associated with lymph node metastasis in gastric cancer.Tumour Biol2013 OctDeng Jdoi: 10.1007/s13277-013-0837-5
25896424Inhibition of STAT3 signaling as critical molecular event in resveratrol-suppressed ovarian cancer cells.J Ovarian Res2015 Apr 22Zhong LXdoi: 10.1186/s13048-015-0152-4.
17920763Inhibition of Stat3 increases doxorubicin sensitivity in a human metastatic breast cancer cell line.Cancer Lett2007 Dec 18Gariboldi MB-
22614117Interleukin 11 regulates endometrial cancer cell adhesion and migration via STAT3.Int J Oncol2012 AugLay Vdoi: 10.3892/ijo.2012.1486
19147545The Fer tyrosine kinase cooperates with interleukin-6 to activate signal transducer and activator of transcription 3 and promote human prostate cancer cell growth.Mol Cancer Res2009 JanZoubeidi Adoi: 10.1158/1541-7786.MCR-08-0117.
20974051Gene regulation by BCL3 in a cervical cancer cell line.Folia Biol (Praha)2010Maldonado V-
25342631Revisiting STAT3 signalling in cancer: new and unexpected biological functions.Nat Rev Cancer2014 NovYu Hdoi: 10.1038/nrc3818.
18639471Tissue-selective RNA interference in prostate cancer cell using prostate specific membrane antigen promoter/enhancer.Urol Oncol2009 Sep-OctZhao Wdoi: 10.1016/j.urolonc.2008.05.003
24402583Combination of AG490, a Jak2 inhibitor, and methylsulfonylmethane synergistically suppresses bladder tumor growth via the Jak2/STAT3 pathway.Int J Oncol2014 MarJoung YHdoi: 10.3892/ijo.2014.2250
21211286[Effects of siltuximab on the interleukin-6/Stat3 signaling pathway in ovarian cancer].Zhonghua Fu Chan Ke Za Zhi2010 NovGuo YQ-
22450744p14(ARF) inhibits the growth of lung adenocarcinoma cells harbouring an EGFR L858R mutation by activating a STAT3-dependent pro-apoptotic signalling pathway.Oncogene2013 Feb 21Ozenne Pdoi: 10.1038/onc.2012.107
17918184EGFR induces expression of IRF-1 via STAT1 and STAT3 activation leading to growth arrest of human cancer cells.Int J Cancer2008 Jan 15Andersen P-
26384345Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines.Oncotarget2015 Nov 24You Ldoi: 10.18632/oncotarget.5592.
21875334A potent oncolytic adenovirus selectively blocks the STAT3 signaling pathway and potentiates cisplatin antitumor activity in ovarian cancer.Hum Gene Ther2012 JanHan Zdoi: 10.1089/hum.2011.101
17531096Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer.Breast Cancer Res2007Berishaj M-
12555068Differentiation-inducing factor-1 (DIF-1) inhibits STAT3 activity involved in gastric cancer cell proliferation via MEK-ERK-dependent pathway.Oncogene2003 Jan 30Kanai M-
25605256ERp57 modulates STAT3 activity in radioresistant laryngeal cancer cells and serves as a prognostic marker for laryngeal cancer.Oncotarget2015 Feb 20Choe MH-
25655308LB-1 Exerts Antitumor Activity in Pancreatic Cancer by Inhibiting HIF-1α and Stat3 Signaling.J Cell Physiol2015 SepNiu Fdoi: 10.1002/jcp.24949.
20977777Aberrant expression and constitutive activation of STAT3 in cervical carcinogenesis: implications in high-risk human papillomavirus infection.Mol Cancer2010 Oct 27Shukla Sdoi: 10.1186/1476-4598-9-282.
18184402Expression of seven gastric cancer-associated genes and its relevance for Wnt, NF-kappaB and Stat3 signaling.APMIS2007 DecHan JCdoi: 10.1111/j.1600-0643.2007.00695.x.
12789269Activation of Stat3 by cell confluence reveals negative regulation of Stat3 by cdk2.Oncogene2003 Jun 5Steinman RA-
18200666Inhibition of signal transducer and activator of transcription 3 expression by RNA interference suppresses invasion through inducing anoikis in human colon cancer cells.World J Gastroenterol2008 Jan 21Fan Y-
18242580Upregulation of survivin by leptin/STAT3 signaling in MCF-7 cells.Biochem Biophys Res Commun2008 Mar 28Jiang Hdoi: 10.1016/j.bbrc.2007.04.004
19796718Osteolytic prostate cancer cells induce the expression of specific cytokines in bone-forming osteoblasts through a Stat3/5-dependent mechanism.Bone2010 FebSchulze Jdoi: 10.1016/j.bone.2009.09.024
20881637A pilot study of preoperative gefitinib for early-stage lung cancer to assess intratumor drug concentration and pathways mediating primary resistance.J Thorac Oncol2010 NovHaura EBdoi: 10.1097/JTO.0b013e3181f38f70.
23166300TCPTP regulates SFK and STAT3 signaling and is lost in triple-negative breast cancers.Mol Cell Biol2013 FebShields BJdoi: 10.1128/MCB.01016-12
24015205Protein kinase C zeta regulates human pancreatic cancer cell transformed growth and invasion through a STAT3-dependent mechanism.PLoS One2013 Aug 28Butler AMdoi: 10.1371/journal.pone.0072061
23326564Targeting CD44-STAT3 signaling by Gemini vitamin D analog leads to inhibition of invasion in basal-like breast cancer.PLoS One2013So JYdoi: 10.1371/journal.pone.0054020
23665025Silencing of the STAT3 signaling pathway reverses the inherent and induced chemoresistance of human ovarian cancer cells.Biochem Biophys Res Commun2013 May 31Han Zdoi: 10.1016/j.bbrc.2013.04.087
24040078MiR-130b is a prognostic marker and inhibits cell proliferation and invasion in pancreatic cancer through targeting STAT3.PLoS One2013 Sep 10Zhao Gdoi: 10.1371/journal.pone.0073803
21410405STAT3 controls matrix metalloproteinase-1 expression in colon carcinoma cells by both direct and AP-1-mediated interaction with the MMP-1 promoter.Biol Chem2011 MayZugowski Cdoi: 10.1515/BC.2011.038
23007731Gamma-aminobutyric acid binds to GABAb receptor to inhibit cholangiocarcinoma cells growth via the JAK/STAT3 pathway.Dig Dis Sci2013 MarHuang Qdoi: 10.1007/s10620-012-2382-2
21711111CK2 inhibitors enhance the radiosensitivity of human non-small cell lung cancer cells through inhibition of stat3 activation.Cancer Biother Radiopharm2011 JunLin YCdoi: 10.1089/cbr.2010.0917
18320073Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells.Neoplasia2008 MarXiong H-
26186918STAT3 polymorphism and Helicobacter pylori CagA strains with higher number of EPIYA-C segments independently increase the risk of gastric cancer.BMC Cancer2015 Jul 19Rocha GAdoi: 10.1186/s12885-015-1533-1.
21668356Association of signal transducer and activator of transcription 3 gene polymorphisms with cervical cancer in Chinese women.DNA Cell Biol2011 NovWang Kdoi: 10.1089/dna.2010.1179
25444909MiR-1181 inhibits stem cell-like phenotypes and suppresses SOX2 and STAT3 in human pancreatic cancer.Cancer Lett2015 Jan 28Jiang Jdoi: 10.1016/j.canlet.2014.11.007
19638983Expression of activated signal transducer and activator of transcription-3 predicts poor prognosis in cervical squamous-cell carcinoma.Br J Cancer2009 Sep 15Takemoto Sdoi: 10.1038/sj.bjc.6605212
22342309Crosstalk of Sp1 and Stat3 signaling in pancreatic cancer pathogenesis.Cytokine Growth Factor Rev2012 Feb-AprHuang Cdoi: 10.1016/j.cytogfr.2012.01.003
18768494Prognostic value of signal transducers and activators of transcription 3 in breast cancer.Cancer Epidemiol Biomarkers Prev2008 SepSheen-Chen SMdoi: 10.1158/1055-9965.EPI-08-0089.
15077160STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells.Oncogene2004 Jun 17Kanda N-
23228483Leptin increases HER2 protein levels through a STAT3-mediated up-regulation of Hsp90 in breast cancer cells.Mol Oncol2013 JunGiordano Cdoi: 10.1016/j.molonc.2012.11.002
21573184A functional nuclear epidermal growth factor receptor, SRC and Stat3 heteromeric complex in pancreatic cancer cells.PLoS One2011 May 5Jaganathan Sdoi: 10.1371/journal.pone.0019605.
24332948A meta-analysis of STAT3 and phospho-STAT3 expression and survival of patients with non-small-cell lung cancer.Eur J Surg Oncol2014 MarXu YHdoi: 10.1016/j.ejso.2013.11.012
26253946RNAi-mediated silencing of Anxa2 inhibits breast cancer cell proliferation by downregulating cyclin D1 in STAT3-dependent pathway.Breast Cancer Res Treat2015 SepZhang Fdoi: 10.1007/s10549-015-3529-6
19175826STAT3 expression in gastric cancer indicates a poor prognosis.J Gastroenterol Hepatol2009 AprKim DYdoi: 10.1111/j.1440-1746.2008.05671.x
18024479REG Ialpha protein mediates an anti-apoptotic effect of STAT3 signaling in gastric cancer cells.Carcinogenesis2008 JanSekikawa A-
25973748Cell Surface GRP78 Accelerated Breast Cancer Cell Proliferation and Migration by Activating STAT3.PLoS One2015 May 14Yao Xdoi: 10.1371/journal.pone.0125634
21310826STAT3 expression, molecular features, inflammation patterns, and prognosis in a database of 724 colorectal cancers.Clin Cancer Res2011 Mar 15Morikawa Tdoi: 10.1158/1078-0432.CCR-10-2694
25586740MicroRNA-10a silencing reverses cisplatin resistance in the A549/cisplatin human lung cancer cell line via the transforming growth factor-β/Smad2/STAT3/STAT5 pathway.Mol Med Rep2015 MaySun Wdoi: 10.3892/mmr.2015.3181
23653350Epithelial to mesenchymal transition promotes breast cancer progression via a fibronectin-dependent STAT3 signaling pathway.J Biol Chem2013 Jun 21Balanis Ndoi: 10.1074/jbc.M113.475277
18448488Rapid activation of Stat3 and ERK1/2 by nicotine modulates cell proliferation in human bladder cancer cells.Toxicol Sci2008 AugChen RJdoi: 10.1093/toxsci/kfn086
22205702Roles of STAT3 and ZEB1 proteins in E-cadherin down-regulation and human colorectal cancer epithelial-mesenchymal transition.J Biol Chem2012 Feb 17Xiong Hdoi: 10.1074/jbc.M111.295964
27180099Hepatitis C virus and its protein NS4B activate the cancer-related STAT3 pathway via the endoplasmic reticulum overload response.Arch Virol2016 AugKong Ldoi: 10.1007/s00705-016-2892-x
24382554STAT3 rs3816769 polymorphism correlates with gene expression level and may predispose to nonsmall cell lung cancer: a preliminary study.Pol Arch Med Wewn2013Doma??ska D-
25269647Zerumbone suppresses EGF-induced CD44 expression through the inhibition of STAT3 in breast cancer cells.Oncol Rep2014 DecKim Sdoi: 10.3892/or.2014.3514
24390815(E)-2,4-Bis(p-hydroxyphenyl)-2-butenal enhanced TRAIL-induced apoptosis in ovarian cancer cells through downregulation of NF-??B/STAT3 pathway.Arch Pharm Res2014 MayCho SHdoi: 10.1007/s12272-013-0326-9
22374428Tissue microarray-based study of patients with lymph node-positive breast cancer shows tyrosine phosphorylation of signal transducer and activator of transcription 3 (tyrosine705-STAT3) is a marker of good prognosis.Clin Transl Oncol2012 MarSonnenblick Adoi: 10.1007/s12094-012-0789-z.
25550533Curcumin and epigallocatechin gallate inhibit the cancer stem cell phenotype via down-regulation of STAT3-NF??B signaling.Anticancer Res2015 JanChung SS-
23962558Abrogation of constitutive Stat3 activity circumvents cisplatin resistant ovarian cancer.Cancer Lett2013 Dec 1Ji Tdoi: 10.1016/j.canlet.2013.08.022
22396544Leukotriene B4 receptor-2 promotes invasiveness and metastasis of ovarian cancer cells through signal transducer and activator of transcription 3 (STAT3)-dependent up-regulation of matrix metalloproteinase 2.J Biol Chem2012 Apr 20Seo JMdoi: 10.1074/jbc.M111.317131
22750444STAT3 repressed USP7 expression is crucial for colon cancer development.FEBS Lett2012 Sep 21Yang Zdoi: 10.1016/j.febslet.2012.06.025
15735721Stat3 regulates genes common to both wound healing and cancer.Oncogene2005 May 12Dauer DJ-
17311011Stat3 activation in human endometrial and cervical cancers.Br J Cancer2007 Feb 26Chen CL-
16425286STAT3 ser727 phosphorylation and its association with negative estrogen receptor status in breast infiltrating ductal carcinoma.Int J Cancer2006 Jun 15Yeh YT-
23623921STAT3 mediates TGF-β1-induced TWIST1 expression and prostate cancer invasion.Cancer Lett2013 Aug 9Cho KHdoi: 10.1016/j.canlet.2013.04.024
21399864Oncostatin M promotes proliferation of ovarian cancer cells through signal transducer and activator of transcription 3.Int J Mol Med2011 JulLi Qdoi: 10.3892/ijmm.2011.647
19664131Expression of activated signal transducer and activator of transcription 3 predicts poor clinical outcome in gastric adenocarcinoma.APMIS2009 AugLee Jdoi: 10.1111/j.1600-0463.2009.02512.x.
21415216Role of ERK-BIM and STAT3-survivin signaling pathways in ALK inhibitor-induced apoptosis in EML4-ALK-positive lung cancer.Clin Cancer Res2011 Apr 15Takezawa Kdoi: 10.1158/1078-0432.CCR-10-2798
21701559Direct reprogramming of stem cell properties in colon cancer cells by CD44.EMBO J2011 Jun 24Su YJdoi: 10.1038/emboj.2011.211.
20422486[Effect of JAK2/STAT3/vimentin signaling pathway on proliferation and migration of human colon cancer cells].Zhonghua Wei Chang Wai Ke Za Zhi2010 AprXu JH-
17911267Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance.Proc Natl Acad Sci U S A2007 Oct 9Zhou J-
26824417IL-32?? inhibits stemness and epithelial-mesenchymal transition of cancer stem cells via the STAT3 pathway in colon cancer.Oncotarget2016 Feb 9Bak Ydoi: 10.18632/oncotarget.7007.
17145757Cdk5 regulates STAT3 activation and cell proliferation in medullary thyroid carcinoma cells.J Biol Chem2007 Feb 2Lin H-
23089473STAT3 & Cytochrome P450 2C9: a novel signaling pathway in liver cancer stem cells.Biomed Pharmacother2012 DecMyung SJdoi: 10.1016/j.biopha.2012.08.011
25487443STAT3 genetic variant, alone and in combination with STAT5b polymorphism, contributes to breast cancer risk and clinical outcomes.Med Oncol2015 JanZhao Hdoi: 10.1007/s12032-014-0375-z
24376586Evaluation of STAT3 signaling in ALDH+ and ALDH+/CD44+/CD24- subpopulations of breast cancer cells.PLoS One2013 Dec 23Lin Ldoi: 10.1371/journal.pone.0082821
19147578Helicobacter pylori cytotoxin-associated gene A activates the signal transducer and activator of transcription 3 pathway in vitro and in vivo.Cancer Res2009 Jan 15Bronte-Tinkew DMdoi: 10.1158/0008-5472.CAN-08-1191.
19492417Expression of angiogenic regulators, VEGF and leptin, is regulated by the EGF/PI3K/STAT3 pathway in colorectal cancer cells.J Cell Physiol2009 OctCascio Sdoi: 10.1002/jcp.21843.
25310198Activation of STAT3 is involved in malignancy mediated by CXCL12-CXCR4 signaling in human breast cancer.Oncol Rep2014 DecLiu Xdoi: 10.3892/or.2014.3536
21442485[Clinical significance of signal transduction and activators of transcription 3, E-cadherin and vimentin in colon cancer].Zhonghua Wei Chang Wai Ke Za Zhi2011 MarZhang C-
25126546Genome-wide uncovering of STAT3-mediated miRNA expression profiles in colorectal cancer cell lines.Biomed Res Int2014Zhang Jdoi: 10.1155/2014/187105
21402692CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (??)-14,15-epoxyeicosatrienoic acid (EET).J Biol Chem2011 May 20Mitra Rdoi: 10.1074/jbc.M110.198515
20204302Dexamethasone treatment inhibits VEGF production via suppression of STAT3 in a head and neck cancer cell line.Oncol Rep2010 AprShim SH-
22581828Activation of the Notch1/STAT3/Twist signaling axis promotes gastric cancer progression.Carcinogenesis2012 AugHsu KWdoi: 10.1093/carcin/bgs165
19223541Sustained Src inhibition results in signal transducer and activator of transcription 3 (STAT3) activation and cancer cell survival via altered Janus-activated kinase-STAT3 binding.Cancer Res2009 Mar 1Sen Bdoi: 10.1158/0008-5472.CAN-08-2944
26125778Effect of Rhizoma paridis total saponins on apoptosis of colorectal cancer cells and imbalance of the JAK/STAT3 molecular pathway induced by IL-6 suppression.Genet Mol Res2015 May 29Teng WJdoi: 10.4238/2015.May.29.11.
23514705Pancreatic cancer-associated stellate cells promote differentiation of myeloid-derived suppressor cells in a STAT3-dependent manner.Cancer Res2013 May 15Mace TAdoi: 10.1158/0008-5472.CAN-12-4601
27665471The reduction of IL-6 gene expression, pAKT, pERK1/2, pSTAT3 signaling pathways and invasion activity by gallic acid in prostate cancer PC3 cells.Biomed Pharmacother2016 DecHeidarian Edoi: 10.1016/j.biopha.2016.09.046
22140473Stat3 mediates expression of autotaxin in breast cancer.PLoS One2011Azare Jdoi: 10.1371/journal.pone.0027851
19647363Lysophosphatidic acid induces STAT3 phosphorylation and ovarian cancer cell motility: their inhibition by curcumin.Cancer Lett2010 Feb 1Seo JHdoi: 10.1016/j.canlet.2009.06.023
25921106Association Study of Single-Nucleotide Polymorphisms of STAT2/STAT3/IFN-γ Genes in Cervical Cancer in Southern Chinese Han Women.Asian Pac J Cancer Prev2015Yuan Y-
23676499Acylglycerol kinase augments JAK2/STAT3 signaling in esophageal squamous cells.J Clin Invest2013 JunChen Xdoi: 10.1172/JCI68143
21479358STAT3-targeting RNA interference inhibits pancreatic cancer angiogenesis in vitro and in vivo.Int J Oncol2011 JunHuang Cdoi: 10.3892/ijo.2011.1000
21577321Upregulation of the signal transducers and activators of transcription 3 (STAT3) pathway in lymphatic metastases of papillary thyroid cancer.Int J Clin Exp Pathol2011 AprZhang J-
21651859[The inhibitory effect of RNA interference on STAT3 expression in liver cancer cell line SMMC7721].Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi2011 JunLiao WJ-
19176463The role of STAT-3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanate.J Natl Cancer Inst2009 Feb 4Sahu RPdoi: 10.1093/jnci/djn470
24816405IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L.Immunity2014 May 15Kryczek Idoi: 10.1016/j.immuni.2014.03.010
24328557Blockage of STAT3 signaling pathway with a decoy oligodeoxynucleotide inhibits growth of human ovarian cancer cells.Cancer Invest2014 JanLiu Mdoi: 10.3109/07357907.2013.861471
27371847[Astaxanthin inhibits proliferation and promotes apoptosis of A549 lung cancer cells via blocking JAK1/STAT3 pathway].Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi2016 JunWu C-
21948749STAT3 gene polymorphisms and susceptibility to non-small cell lung cancer.Genet Mol Res2011 Aug 26Jiang Bdoi: 10.4238/vol10-3gmr1071.
21632716Enhanced cancer immunotherapy using STAT3-depleted dendritic cells with high Th1-inducing ability and resistance to cancer cell-derived inhibitory factors.J Immunol2011 Jul 1Iwata-Kajihara Tdoi: 10.4049/jimmunol.1002067
22104200Constitutive activation of signal transducers and activators of transcription 3 correlates with better prognosis, cell proliferation and hypoxia-inducible factor-1α in human gastric cancer.Pathobiology2011Woo Sdoi: 10.1159/000321696
24891218STAT3 signaling is activated preferentially in tumor-initiating cells in claudin-low models of human breast cancer.Stem Cells2014 OctWei Wdoi: 10.1002/stem.1752.
20232316miR-20b modulates VEGF expression by targeting HIF-1 alpha and STAT3 in MCF-7 breast cancer cells.J Cell Physiol2010 JulCascio Sdoi: 10.1002/jcp.22126.
27173233Role of the IL-11/STAT3 signaling pathway in human chronic atrophic gastritis and gastric cancer.Genet Mol Res2016 Apr 25Wang DQdoi: 10.4238/gmr.15027358.
24760274Stat3 inhibits Beclin 1 expression through recruitment of HDAC3 in nonsmall cell lung cancer cells.Tumour Biol2014 JulMiao LJdoi: 10.1007/s13277-014-1961-6
23820254STAT3 upregulates miR-92a to inhibit RECK expression and to promote invasiveness of lung cancer cells.Br J Cancer2013 Aug 6Lin HYdoi: 10.1038/bjc.2013.349
19578748MUC1 is a downstream target of STAT3 and regulates lung cancer cell survival and invasion.Int J Oncol2009 AugGao J-
24199193Role of STAT3 in cancer metastasis and translational advances.Biomed Res Int2013Kamran MZdoi: 10.1155/2013/421821
19010822Mesothelin-induced pancreatic cancer cell proliferation involves alteration of cyclin E via activation of signal transducer and activator of transcription protein 3.Mol Cancer Res2008 NovBharadwaj Udoi: 10.1158/1541-7786.MCR-08-0095.
22218594Pien Tze Huang inhibits tumor cell proliferation and promotes apoptosis via suppressing the STAT3 pathway in a colorectal cancer mouse model.Int J Oncol2012 MayZhuang Qdoi: 10.3892/ijo.2012.1326
22050790Inhibition of JAK2/STAT3 signalling induces colorectal cancer cell apoptosis via mitochondrial pathway.J Cell Mol Med2012 AugDu Wdoi: 10.1111/j.1582-4934.2011.01483.x.
19288493Role of RAF/MEK/ERK pathway, p-STAT-3 and Mcl-1 in sorafenib activity in human pancreatic cancer cell lines.J Cell Physiol2009 JulUlivi Pdoi: 10.1002/jcp.21753.
25868978Resistin and interleukin-6 exhibit racially-disparate expression in breast cancer patients, display molecular association and promote growth and aggressiveness of tumor cells through STAT3 activation.Oncotarget2015 May 10Deshmukh SK-
23446809Tumor STAT3 tyrosine phosphorylation status, as a predictor of benefit from adjuvant chemotherapy for breast cancer.Breast Cancer Res Treat2013 AprSonnenblick Adoi: 10.1007/s10549-013-2453-x
20197401Sorafenib inhibits STAT3 activation to enhance TRAIL-mediated apoptosis in human pancreatic cancer cells.Mol Cancer Ther2010 MarHuang Sdoi: 10.1158/1535-7163.MCT-09-1004
19658181STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells.Stem Cells2009 OctSherry MMdoi: 10.1002/stem.185.
24388873Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors.Biochim Biophys Acta2014 AprSiveen KSdoi: 10.1016/j.bbcan.2013.12.005
19020709Guggulsterone inhibits angiogenesis by blocking STAT3 and VEGF expression in colon cancer cells.Oncol Rep2008 DecKim ES-
22723956miR-337-3p and its targets STAT3 and RAP1A modulate taxane sensitivity in non-small cell lung cancers.PLoS One2012Du Ldoi: 10.1371/journal.pone.0039167
18060032Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas.J Clin Invest2007 DecGao SP-
17344214leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3.J Biol Chem2007 May 4Saxena NK-
27344168Valosin-containing protein (VCP) promotes the growth, invasion, and metastasis of colorectal cancer through activation of STAT3 signaling.Mol Cell Biochem2016 JulFu Qdoi: 10.1007/s11010-016-2746-6
24431073XPO1 (CRM1) inhibition represses STAT3 activation to drive a survivin-dependent oncogenic switch in triple-negative breast cancer.Mol Cancer Ther2014 MarCheng Ydoi: 10.1158/1535-7163.MCT-13-0416
21174186Downregulation of STAT3 signaling induces apoptosis but also promotes anti-apoptotic gene expression in human pancreatic cancer cell lines.Tumour Biol2011 JunGlienke Wdoi: 10.1007/s13277-010-0143-4
20331635Bcl-XL and STAT3 mediate malignant actions of gamma-irradiation in lung cancer cells.Cancer Sci2010 JunHo JNdoi: 10.1111/j.1349-7006.2010.01552.x
19951849Expression of signal transducer and activator of transcription 3 and suppressor of cytokine signaling 3 in urothelial carcinoma.Kaohsiung J Med Sci2009 DecHuang WTdoi: 10.1016/S1607-551X(09)70569-8.
23894143Niclosamide overcomes acquired resistance to erlotinib through suppression of STAT3 in non-small cell lung cancer.Mol Cancer Ther2013 OctLi Rdoi: 10.1158/1535-7163.MCT-13-0095
21072904STAT-3 correlates with lymph node metastasis and cell survival in gastric cancer.World J Gastroenterol2010 Nov 14Deng JY-
25070049MiR-7, inhibited indirectly by lincRNA HOTAIR, directly inhibits SETDB1 and reverses the EMT of breast cancer stem cells by downregulating the STAT3 pathway.Stem Cells2014 NovZhang Hdoi: 10.1002/stem.1795.
16959370Differential expression of STAT5 and Bcl-xL, and high expression of Neu and STAT3 in non-small-cell lung carcinoma.Lung Cancer2006 NovS??nchez-Ceja SG-
26500281Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal transducer and activator of transcription 3 (STAT3) signalling in HER2-overexpressing BT-474 breast cancer cells.Biosci Rep2015 Oct 23Seo HSdoi: 10.1042/BSR20150165.
12640143Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth.Proc Natl Acad Sci U S A2003 Apr 1Leong PL-
21418908[Effects of JAK2/STAT3 signaling pathway on angiogenesis in non-small cell lung cancer].Zhonghua Yi Xue Za Zhi2011 Feb 15Zhao M-
15958548Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors.Cancer Res2005 Jun 15Alvarez JV-
15936715Adiponectin activates c-Jun NH2-terminal kinase and inhibits signal transducer and activator of transcription 3.Biochem Biophys Res Commun2005 Jul 22Miyazaki T-
17975158Targeting heat shock protein 90 in pancreatic cancer impairs insulin-like growth factor-I receptor signaling, disrupts an interleukin-6/signal-transducer and activator of transcription 3/hypoxia-inducible factor-1alpha autocrine loop, and reduces orthotopic tumor growth.Clin Cancer Res2007 Nov 1Lang SA-
28112380miR520c blocks EMT progression of human breast cancer cells by repressing STAT3.Oncol Rep2017 MarWang Ndoi: 10.3892/or.2017.5393
27748760Glutamine activates STAT3 to control cancer cell proliferation independently of glutamine metabolism.Oncogene2017 AprCacace Adoi: 10.1038/onc.2016.364
28085101Shp2 Inhibits Proliferation of Esophageal Squamous Cell Cancer via Dephosphorylation of Stat3.Int J Mol Sci2017 Jan 12Qi Cdoi: 10.3390/ijms18010134.
27122665Thymoquinone inhibits proliferation in gastric cancer via the STAT3 pathway in vivo and in vitro.World J Gastroenterol2016 Apr 28Zhu WQdoi: 10.3748/wjg.v22.i16.4149.
28209618The STAT3-miRNA-92-Wnt Signaling Pathway Regulates Spheroid Formation and Malignant Progression in Ovarian Cancer.Cancer Res2017 Apr 15Chen MWdoi: 10.1158/0008-5472.CAN-16-1115
28376152Co-activation of STAT3 and YES-Associated Protein 1 (YAP1) Pathway in EGFR-Mutant NSCLC.J Natl Cancer Inst2017 Sep 1Chaib Idoi: 10.1093/jnci/djx014.
27748818STAT3 as a potential therapeutic target in ALDH+ and CD44+/CD24+ stem cell-like pancreatic cancer cells.Int J Oncol2016 DecLin Ldoi: 10.3892/ijo.2016.3728
28351333Splicing factor hnRNPA2B1 contributes to tumorigenic potential of breast cancer cells through STAT3 and ERK1/2 signaling pathway.Tumour Biol2017 MarHu Ydoi: 10.1177/1010428317694318.
27150039IRAK-M Expression in Tumor Cells Supports Colorectal Cancer Progression through Reduction of Antimicrobial Defense and Stabilization of STAT3.Cancer Cell2016 May 9Kesselring Rdoi: 10.1016/j.ccell.2016.03.014
26212010Stat3 regulates ErbB-2 expression and co-opts ErbB-2 nuclear function to induce miR-21 expression, PDCD4 downregulation and breast cancer metastasis.Oncogene2016 Apr 28Venturutti Ldoi: 10.1038/onc.2015.281
28618941Molecular interplay of pro-inflammatory transcription factors and non-coding RNAs in esophageal squamous cell carcinoma.Tumour Biol2017 JunSundaram GMdoi: 10.1177/1010428317705760.
27875298Benzyl Isothiocyanate (BITC) Induces Reactive Oxygen Species-dependent Repression of STAT3 Protein by Down-regulation of Specificity Proteins in Pancreatic Cancer.J Biol Chem2016 Dec 30Kasiappan Rdoi: 10.1074/jbc.M116.746339
26738736IL-6/STAT3 Plays a Regulatory Role in the Interaction Between Pancreatic Stellate Cells and Cancer Cells.Dig Dis Sci2016 JunHamada Sdoi: 10.1007/s10620-015-4001-5
27576197Gemcitabine treatment promotes pancreatic cancer stemness through the Nox/ROS/NF-??B/STAT3 signaling cascade.Cancer Lett2016 Nov 1Zhang Zdoi: 10.1016/j.canlet.2016.08.023
27518872MiR-148a Functions as a Tumor Suppressor by Targeting CCK-BR via Inactivating STAT3 and Akt in Human Gastric Cancer.PLoS One2016 Aug 12Yu Bdoi: 10.1371/journal.pone.0158961
27197152Myeloid-Derived Suppressor Cells Endow Stem-like Qualities to Breast Cancer Cells through IL6/STAT3 and NO/NOTCH Cross-talk Signaling.Cancer Res2016 Jun 1Peng Ddoi: 10.1158/0008-5472.CAN-15-2528
27504822The Role of p-STAT3 as a Prognostic and Clinicopathological Marker in Colorectal Cancer: A Systematic Review and Meta-Analysis.PLoS One2016 Aug 9Ji Kdoi: 10.1371/journal.pone.0160125
27264264Cyclosporine A sensitizes human non-small cell lung cancer cells to gefitinib through inhibition of STAT3.Cancer Lett2016 Aug 28Shou Jdoi: 10.1016/j.canlet.2016.06.002
28114355The G Protein-Coupled Receptor RAI3 Is an Independent Prognostic Factor for Pancreatic Cancer Survival and Regulates Proliferation via STAT3 Phosphorylation.PLoS One2017 Jan 23Jahny Edoi: 10.1371/journal.pone.0170390
28122338Chemotherapy-mediated miR-29b expression inhibits the invasion and angiogenesis of cervical cancer.Oncotarget2017 Feb 28Li Ydoi: 10.18632/oncotarget.14738.
28223169IGF1/IGF1R/STAT3 signaling-inducible IFITM2 promotes gastric cancer growth and metastasis.Cancer Lett2017 May 1Xu Ldoi: 10.1016/j.canlet.2017.02.014
27820701MicroRNA-424 impairs ubiquitination to activate STAT3 and promote prostate tumor progression.J Clin Invest2016 Dec 1Dallavalle Cdoi: 10.1172/JCI86505
28338932Ursolic acid derivative FZU-03,010 inhibits STAT3 and induces cell cycle arrest and apoptosis in renal and breast cancer cells.Acta Biochim Biophys Sin (Shanghai)2017 Apr 1Li Wdoi: 10.1093/abbs/gmx012.
28178652STAT3 is required for MiR-17-5p-mediated sensitization to chemotherapy-induced apoptosis in breast cancer cells.Oncotarget2017 Feb 28Liao XHdoi: 10.18632/oncotarget.15000.
28186991C-terminal truncated hepatitis B virus X protein regulates tumorigenicity, self-renewal and drug resistance via STAT3/Nanog signaling pathway.Oncotarget2017 Apr 4Ching RHHdoi: 10.18632/oncotarget.15183.
28859543The relationship between microRNAs and the STAT3-related signaling pathway in cancer.Tumour Biol2017 JulZhang Ldoi: 10.1177/1010428317719869.
27524414Stat3 contributes to cancer progression by regulating Jab1/Csn5 expression.Oncogene2017 Feb 23Pan Ydoi: 10.1038/onc.2016.271
28810143Genomic Evolution of Breast Cancer Metastasis and Relapse.Cancer Cell2017 Aug 14Yates LRdoi: 10.1016/j.ccell.2017.07.005.
28602977BRM/SMARCA2 promotes the proliferation and chemoresistance ofpancreatic cancer cells by targeting JAK2/STAT3 signaling.Cancer Lett2017 Aug 28Zhang Zdoi: 10.1016/j.canlet.2017.05.006
28423613Secreted GRP78 activates EGFR-SRC-STAT3 signaling and confers the resistance to sorafeinib in HCC cells.Oncotarget2017 Mar 21Li Rdoi: 10.18632/oncotarget.15223.
28797050Correlation between p-STAT3 overexpression and prognosis in lung cancer: A systematic review and meta-analysis.PLoS One2017 Aug 10Tong Mdoi: 10.1371/journal.pone.0182282
28499590MiR-93-5p inhibits the EMT of breast cancer cells via targeting MKL-1 and STAT3.Exp Cell Res2017 Aug 1Xiang Ydoi: 10.1016/j.yexcr.2017.05.007
28859117Phosphorylation of STAT3 at Tyr705 regulates MMP-9 production in epithelial ovarian cancer.PLoS One2017 Aug 31Jia ZHdoi: 10.1371/journal.pone.0183622
28061480Co-ordinated overexpression of SIRT1 and STAT3 is associated with poor survival outcome in gastric cancer patients.Oncotarget2017 Mar 21Zhang Sdoi: 10.18632/oncotarget.14473.
28061445The clinical significance and underlying correlation of pStat-3 and integrin αvβ6 expression in gallbladder cancer.Oncotarget2017 Mar 21Enyu Ldoi: 10.18632/oncotarget.14444.
28988111PAI-1/PIAS3/Stat3/miR-34a forms a positive feedback loop to promote EMT-mediated metastasis through Stat3 signaling in Non-small cell lung cancer.Biochem Biophys Res Commun2017 Dec 2Lin Xdoi: 10.1016/j.bbrc.2017.10.014
28581518Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3.Oncogene2017 Oct 12Sengupta Sdoi: 10.1038/onc.2017.164
28842285miR-93-5p/IFNAR1 axis promotes gastric cancer metastasis through activating the STAT3 signaling pathway.Cancer Lett2017 Nov 1Ma DHdoi: 10.1016/j.canlet.2017.08.017
27289429Caveolin-1 Mediates Low-Intensity Ultrasound-Induced Apoptosis via Downregulation of Signal Transducer and Activator of Transcription 3 Phosphorylation in Laryngeal Carcinoma Cells.Ultrasound Med Biol2016 SepYe Qdoi: 10.1016/j.ultrasmedbio.2016.04.017
27521604STAT3-induced WDR1 overexpression promotes breast cancer cell migration.Cell Signal2016 NovLee JHdoi: 10.1016/j.cellsig.2016.08.006
28321160miR-1181 inhibits invasion and proliferation via STAT3 in pancreatic cancer.World J Gastroenterol2017 Mar 7Wang Jdoi: 10.3748/wjg.v23.i9.1594.
27079734Docosahexaenoic acid inhibits Helicobacter pylori-induced STAT3 phosphorylation through activation of PPARγ.Mol Nutr Food Res2016 JunJi HGdoi: 10.1002/mnfr.201600009
27049829LGR5 expression is controled by IKKα in basal cell carcinoma through activating STAT3 signaling pathway.Oncotarget2016 May 10Jia Jdoi: 10.18632/oncotarget.8465.
27512943Isoproterenol regulates CD44 expression in gastric cancer cells through STAT3/MicroRNA373 cascade.Biomaterials2016 OctWei Bdoi: 10.1016/j.biomaterials.2016.07.040
27049718Associations of potentially functional variants in IL-6, JAKs and STAT3 with gastric cancer risk in an eastern Chinese population.Oncotarget2016 May 10Zhou Fdoi: 10.18632/oncotarget.8492.
27248826The inflammatory/cancer-related IL-6/STAT3/NF-??B positive feedback loop includes AUF1 and maintains the active state of breast myofibroblasts.Oncotarget2016 Jul 5Hendrayani SFdoi: 10.18632/oncotarget.9633.
27577070A single nucleotide polymorphism in the 3'-UTR of STAT3 regulates its expression and reduces risk of pancreatic cancer in a Chinese population.Oncotarget2016 Sep 20Zhu Bdoi: 10.18632/oncotarget.11607.
27626181LINC00520 is induced by Src, STAT3, and PI3K and plays a functional role in breast cancer.Oncotarget2016 Dec 13Henry WSdoi: 10.18632/oncotarget.11962.
26812074Long non-coding RNA DILC regulates liver cancer stem cells via IL-6/STAT3 axis.J Hepatol2016 JunWang Xdoi: 10.1016/j.jhep.2016.01.019
27694691Interleukin-6 expression contributes to lapatinib resistance through maintenance of stemness property in HER2-positive breast cancer cells.Oncotarget2016 Sep 20Huang WCdoi: 10.18632/oncotarget.11471.
27494878CD24 promoted cancer cell angiogenesis via Hsp90-mediated STAT3/VEGF signaling pathway in colorectal cancer.Oncotarget2016 Aug 23Wang Xdoi: 10.18632/oncotarget.10971.
27344294Expression of STAT3 in Prostate Cancer Metastases.Eur Urol2017 MarDon-Doncow Ndoi: 10.1016/j.eururo.2016.06.018
27900636Cardamonin represses proliferation, invasion, and causes apoptosis through the modulation of signal transducer and activator of transcription 3 pathway in prostate cancer.Apoptosis2017 JanZhang Jdoi: 10.1007/s10495-016-1313-7.
28030809Genomic regulation of invasion by STAT3 in triple negative breast cancer.Oncotarget2017 Jan 31McDaniel JMdoi: 10.18632/oncotarget.14153.
27793010Elevated AEG-1 expression in macrophages promotes hypopharyngeal cancer invasion through the STAT3-MMP-9 signaling pathway.Oncotarget2016 Nov 22Liu Xdoi: 10.18632/oncotarget.12886.
27732936The ETS factor ESE3/EHF represses IL-6 preventing STAT3 activation and expansion of the prostate cancer stem-like compartment.Oncotarget2016 Nov 22Albino Ddoi: 10.18632/oncotarget.12525.
27602766Rig-G is a growth inhibitory factor of lung cancer cells that suppresses STAT3 and NF-??B.Oncotarget2016 Oct 4Li Ddoi: 10.18632/oncotarget.11797.
28440514Silibinin downregulates MMP2 expression via Jak2/STAT3 pathway and inhibits the migration and invasive potential in MDA-MB-231 cells.Oncol Rep2017 JunByun HJdoi: 10.3892/or.2017.5588
28455144Identification of NCK1 as a novel downstream effector of STAT3 in colorectal cancer metastasis and angiogenesis.Cell Signal2017 AugZhang Fdoi: 10.1016/j.cellsig.2017.04.020
29288516Interleukin-6/signal transducer and activator of transcription 3 promotes prostate cancer resistance to androgen deprivation therapy via regulating pituitary tumor transforming gene 1 expression.Cancer Sci2018 MarHuang Sdoi: 10.1111/cas.13493
27602757Pancreatic stellate cell secreted IL-6 stimulates STAT3 dependent invasiveness of pancreatic intraepithelial neoplasia and cancer cells.Oncotarget2016 Oct 4Nagathihalli NSdoi: 10.18632/oncotarget.11786.
28422733The transcriptional STAT3 is a potential target, whereas transcriptional STAT5A/5B/6 are new biomarkers for prognosis in human breast carcinoma.Oncotarget2017 May 30Wu HTdoi: 10.18632/oncotarget.16748.
28448787Relationship between HER2 and JAK/STAT-SOCS3 signaling pathway and clinicopathological features and prognosis of ovarian cancer.Cancer Biol Ther2017 May 4Shang AQdoi: 10.1080/15384047.2017.1310343
28470457Tyr23 phosphorylation of Anxa2 enhances STAT3 activation and promotes proliferation and invasion of breast cancer cells.Breast Cancer Res Treat2017 JulYuan Jdoi: 10.1007/s10549-017-4271-z
28750679miR-500a-3p promotes cancer stem cells properties via STAT3 pathway in human hepatocellular carcinoma.J Exp Clin Cancer Res2017 Jul 27Jiang Cdoi: 10.1186/s13046-017-0568-3.
28729467STAT3 activation by leptin receptor is essential for TNBC stem cell maintenance.Endocr Relat Cancer2017 AugThiagarajan PSdoi: 10.1530/ERC-16-0349.
27556503Immunosuppressive effect of bladder cancer on function of dendritic cells involving of Jak2/STAT3 pathway.Oncotarget2016 Sep 27Xiu Wdoi: 10.18632/oncotarget.11434.
29572071Long non-coding RNA HOTAIR and STAT3 synergistically regulate the cervical cancer cell migration and invasion.Chem Biol Interact2018 Apr 25Zhang Ydoi: 10.1016/j.cbi.2018.03.010
28584133Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells.Proc Natl Acad Sci U S A2017 Jun 20Genini Ddoi: 10.1073/pnas.1615730114
27539371In vitro comparative studies of resveratrol and triacetylresveratrol on cell proliferation, apoptosis, and STAT3 and NF??B signaling in pancreatic cancer cells.Sci Rep2016 Aug 19Duan Jdoi: 10.1038/srep31672.
28388577IL-6R/STAT3/miR-204 feedback loop contributes to cisplatin resistance of epithelial ovarian cancer cells.Oncotarget2017 Jun 13Zhu Xdoi: 10.18632/oncotarget.16610.
28574510RIP4 inhibits STAT3 signaling to sustain lung adenocarcinoma differentiation.Cell Death Differ2017 OctKopparam Jdoi: 10.1038/cdd.2017.81
27922075Cancer-associated fibroblasts treated with cisplatin facilitates chemoresistance of lung adenocarcinoma through IL-11/IL-11R/STAT3 signaling pathway.Sci Rep2016 Dec 6Tao Ldoi: 10.1038/srep38408.
28765941B7-H3 is related to tumor progression in ovarian cancer.Oncol Rep2017 OctZhang Jdoi: 10.3892/or.2017.5858
29617099A Second-Generation Proteasome Inhibitor and Doxorubicin Modulates IL-6, pSTAT-3 and NF-kB Activity in MDA-MB-231 Breast Cancer Cells.J Nanosci Nanotechnol2017 JanVyas D-
27824145Sulforaphane improves chemotherapy efficacy by targeting cancer stem cell-like properties via the miR-124/IL-6R/STAT3 axis.Sci Rep2016 Nov 8Wang Xdoi: 10.1038/srep36796.
28569433Ascochlorin Suppresses MMP-2-Mediated Migration and Invasion by Targeting FAK and JAK-STAT Signaling Cascades.J Cell Biochem2018 JanCho HJdoi: 10.1002/jcb.26179
28498494A Mercaptoacetamide-Based Class II Histone Deacetylase Inhibitor Suppresses Cell Migration and Invasion in Monomorphic Malignant Human Glioma Cells by Inhibiting FAK/STAT3 Signaling.J Cell Biochem2017 DecNam JHdoi: 10.1002/jcb.26133
29200949Over-expression of Activated Signal Transducer and Activator of Transcription 3 Predicts Poor Prognosis in Upper Tract Urothelial Carcinoma.Int J Med Sci2017 Oct 15Li WMdoi: 10.7150/ijms.17367
28656307SIRT6 inhibits growth of gastric cancer by inhibiting JAK2/STAT3 pathway.Oncol Rep2017 AugZhou Jdoi: 10.3892/or.2017.5753
29929193Induction of Pro-Inflammatory Response via Activated Macrophage-Mediated NF-??B and STAT3 Pathways in Gastric Cancer Cells.Cell Physiol Biochem2018Zhou Ydoi: 10.1159/000490829
29286124MicroRNA-454 inhibits nonsmall cell lung cancer cells growth and metastasis via targeting signal transducer and activator of transcription-3.Mol Med Rep2018 MarLiu Sdoi: 10.3892/mmr.2017.8350
29207087p-STAT3 in luminal breast cancer: Integrated RNA-protein pooled analysis and results from the BIG 2-98 phase III trial.Int J Oncol2018 FebSonnenblick Adoi: 10.3892/ijo.2017.4212
29181822Schisandrin A reverses doxorubicin-resistant human breast cancer cell line by the inhibition of P65 and Stat3 phosphorylation.Breast Cancer2018 MarZhang ZLdoi: 10.1007/s12282-017-0821-9
29393444Tyrphostin B42 attenuates trichostatin A-mediated resistance in pancreatic cancer cells by antagonizing IL-6/JAK2/STAT3 signaling.Oncol Rep2018 AprZhang Xdoi: 10.3892/or.2018.6241
29393468Saffron carotenoids inhibit STAT3 activation and promote apoptotic progression in IL-6-stimulated liver cancer cells.Oncol Rep2018 AprKim Bdoi: 10.3892/or.2018.6232
28466252TMPRSS4 Upregulates TWIST1 Expression through STAT3 Activation to Induce Prostate Cancer Cell Migration.Pathol Oncol Res2018 AprJianwei Zdoi: 10.1007/s12253-017-0237-z
29684351STAT3 activation by IL-6 from adipose-derived stem cells promotes endometrial carcinoma proliferation and metastasis.Biochem Biophys Res Commun2018 Jun 7Chu Ydoi: 10.1016/j.bbrc.2018.04.121
29641255MiR-17 Regulates Prostate Cancer Cell Proliferation and Apoptosis Through Inhibiting JAK-STAT3 Signaling Pathway.Cancer Biother Radiopharm2018 AprDai Hdoi: 10.1089/cbr.2017.2386.
29749438Oct4 suppresses IRinduced premature senescence in breast cancer cells through STAT3- and NF??B-mediated IL24 production.Int J Oncol2018 JulKim JYdoi: 10.3892/ijo.2018.4391
29750424Stat3/Oct-4/c-Myc signal circuit for regulating stemness-mediated doxorubicin resistance of triple-negative breast cancer cells and inhibitory effects of WP1066.Int J Oncol2018 JulCheng CCdoi: 10.3892/ijo.2018.4399
29574157Interleukin-23 promotes the migration and invasion of gastric cancer cells by inducing epithelial-to-mesenchymal transition via the STAT3 pathway.Biochem Biophys Res Commun2018 May 5Xu Xdoi: 10.1016/j.bbrc.2018.03.144
29222039The role of STAT3 in leading the crosstalk between human cancers and the immune system.Cancer Lett2018 Feb 28Wang Ydoi: 10.1016/j.canlet.2017.12.003
29970682Human epidermal growth factor receptor 2 expressions and Janus-activated kinase/signal transducer and activator of transcription 3-suppressor of cytokine signaling 3 pathway may be associated with clinicopathological features and prognosis of gastric cancer.J Cancer Res Ther2018 JunXu Wdoi: 10.4103/0973-1482.235348.
30015981NFIB promotes cell growth, aggressiveness, metastasis and EMT of gastric cancer through the Akt/Stat3 signaling pathway.Oncol Rep2018 SepWu Cdoi: 10.3892/or.2018.6574
29575778Signal transducer and activator of transcription3 overexpression promotes lymph node micrometastasis in early-stage non-small cell lung cancer.Thorac Cancer2018 MayYu Ydoi: 10.1111/1759-7714.12598
29633065KDM4B promotes DNA damage response via STAT3 signaling and is a target of CREB in colorectal cancer cells.Mol Cell Biochem2018 DecDeng WWdoi: 10.1007/s11010-018-3345-5
30391438lncARSR promotes liver cancer stem cells expansion via STAT3 pathway.Gene2019 Mar 1Yang Cdoi: 10.1016/j.gene.2018.10.087
30091994STAT3 expression is a prognostic marker in upper urinary tract urothelial carcinoma.PLoS One2018 Aug 9Matsuzaki Kdoi: 10.1371/journal.pone.0201256
26650241Hes1 Increases the Invasion Ability of Colorectal Cancer Cells via the STAT3-MMP14 Pathway.PLoS One2015 Dec 9Weng MTdoi: 10.1371/journal.pone.0144322
30231553STAT3 in Breast Cancer Onset and Progression: A Matter of Time and Context.Int J Mol Sci2018 Sep 18Segatto Idoi: 10.3390/ijms19092818.
29449694Interaction between STAT3 and GLI1/tGLI1 oncogenic transcription factors promotes the aggressiveness of triple-negative breast cancers and HER2-enriched breast cancer.Oncogene2018 MaySirkisoon SRdoi: 10.1038/s41388-018-0132-4
30562490Furowanin A-induced autophagy alleviates apoptosis and promotes cell cycle arrest via inactivation STAT3/Mcl-1 axis in colorectal cancer.Life Sci2019 Feb 1Ma Zdoi: 10.1016/j.lfs.2018.12.027
29636548Hypoxia-induced exosomes contribute to a more aggressive and chemoresistant ovarian cancer phenotype: a novel mechanism linking STAT3/Rab proteins.Oncogene2018 JulDorayappan KDPdoi: 10.1038/s41388-018-0189-0
30243096PMA treated THP-1-derived-IL-6 promotes EMT of SW48 through STAT3/ERK-dependent activation of Wnt/β-catenin signaling pathway.Biomed Pharmacother2018 DecGao Sdoi: 10.1016/j.biopha.2018.09.067
30221675Y-box binding protein-1 and STAT3 independently regulate ATP-binding cassette transporters in the chemoresistance of gastric cancer cells.Int J Oncol2018 DecChua PJdoi: 10.3892/ijo.2018.4557
29716674MicroRNA-411 Inhibits Cervical Cancer Progression by Directly Targeting STAT3.Oncol Res2019 Feb 21Shan Ddoi: 10.3727/096504018X15247361080118
30598340pSTAT3 expression associated with survival and mammographic density of breast cancer patients.Pathol Res Pract2019 FebRadenkovic Sdoi: 10.1016/j.prp.2018.12.023
30316864S1PR1 predicts patient survival and promotes chemotherapy drug resistance in gastric cancer cells through STAT3 constitutive activation.EBioMedicine2018 NovSong Sdoi: 10.1016/j.ebiom.2018.10.005
29481824Regulation of immunophenotype modulation of monocytes-macrophages from M1 into M2 by prostate cancer cell-culture supernatant via transcription factor STAT3.Immunol Lett2018 AprSol??s-Mart??nez Rdoi: 10.1016/j.imlet.2018.02.009
29884911RAC1-GTP promotes epithelial-mesenchymal transition and invasion of colorectal cancer by activation of STAT3.Lab Invest2018 AugZhou Kdoi: 10.1038/s41374-018-0071-2
29117631Astrocyte elevated gene-1 promotes invasion and epithelial-mesenchymal transition in bladder cancer cells through activation of signal transducer and activator of transcription 3.Int J Urol2018 FebYang Xdoi: 10.1111/iju.13486

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1742315804Splice_Regionnovel0.18
BLCAchr1742324795Missense_MutationNAE506K0.29
BLCAchr1742339328Missense_MutationnovelR152W0.45
BLCAchr1742326151Missense_MutationnovelE444K0.17
BLCAchr1742323354Nonsense_MutationnovelE552Sfs*60.17
BLCAchr1742325063Splice_Regionnovel0.28
BLCAchr1742329458Splice_SitenovelX412_splice0.08
BLCAchr1742329573Missense_MutationnovelS405F0.09
BLCAchr1742324978SilentNAL483L0.04
BLCAchr1742315823Intronnovel0.18
BLCAchr1742326178Missense_MutationnovelE435K0.07
BLCAchr1742334027Missense_MutationnovelQ274E0.34
BRCAchr1742316673Intronnovel0.71
BRCAchr1742348489Missense_MutationnovelL10V0.26
BRCAchr1742329558Missense_MutationNAH410R0.17
BRCAchr1742329423Missense_Mutationrs113994137R423Q0.39
BRCAchr1742323316Missense_MutationnovelW564C0.24
BRCAchr1742316859SilentNAR729R0.29
BRCAchr1742329636Missense_MutationNAF384Y0.46
BRCAchr1742345567Missense_MutationNAA122T0.18
BRCAchr1742316067Intronnovel0.57
BRCAchr1742316875Missense_MutationNAL724P0.3
BRCAchr1742323037Missense_MutationnovelV619L0.04
BRCAchr1742325052SilentnovelL459L0.06
CESCchr1742322443Missense_Mutationrs770986654N647I0.27
CESCchr1742322402Missense_Mutationrs747639500D661Y0.14
CESCchr1742323046Missense_MutationNAE616K0.14
CESCchr17423144383'UTRnovel0.3
CESCchr17423152813'UTRnovel0.2
CESCchr17423144373'UTRrs7565281470.54
CESCchr17423138403'UTRnovel0.21
CESCchr17423145283'UTRnovel0.28
CESCchr1742322364SilentnovelL673L0.22
CESCchr17423138783'UTRnovel0.55
CESCchr1742315746Nonstop_MutationNA*771Sext*650.32
COADchr1742333920Silentrs779733888I309I0.37
COADchr1742348443Missense_MutationNAS25N0.44
COADchr1742324848Splice_SiteNAX489_splice0.23
COADchr1742316861Frame_Shift_DelNAR729Afs*30.26
COADchr1742333920Silentrs779733888I309I0.31
COADchr1742329570Missense_MutationNAA406V0.24
COADchr1742316028IntronNA0.64
COADchr1742333939Missense_MutationNAP303L0.51
COADchr1742329413SilentnovelC426C0.09
COADchr1742316861Frame_Shift_DelNAR729Afs*30.39
COADchr1742346574Missense_MutationNAL90I0.32
COADchr17423157143'UTRrs3741071240.19
COADchr17423156223'UTRnovel0.41
DLBCchr1742323045Missense_MutationNAE616G0.35
DLBCchr1742323050Missense_MutationNAS614R0.28
DLBCchr1742322401Missense_MutationNAD661V0.15
DLBCchr1742333728Missense_MutationNAH332Y0.33
ESCAchr1742333722Missense_MutationnovelD334Y0.18
ESCAchr1742339317SilentnovelV155V0.18
ESCAchr17423145693'UTRnovel0.36
ESCAchr1742331474Splice_RegionnovelD369D0.17
GBMchr1742324773Missense_MutationnovelS513Y0.3
GBMchr1742322461Missense_MutationNAT641I0.11
GBMchr1742323622Missense_MutationnovelP535L0.19
GBMchr17423157403'UTRnovel0.06
GBMchr1742323020SilentnovelV624V0.28
GBMchr1742338733Missense_MutationnovelG183E0.06
GBMchr17423156673'UTRnovel0.08
GBMchr1742324985Missense_MutationnovelN481I0.12
HNSCchr1742338733Missense_MutationnovelG183E0.39
HNSCchr1742322401Missense_MutationNAD661V0.22
HNSCchr17423156943'UTRnovel0.29
HNSCchr1742333951Missense_MutationnovelV299A0.25
HNSCchr1742329586Missense_MutationnovelN401D0.48
HNSCchr1742324770Missense_MutationnovelS514Y0.26
HNSCchr1742334015Missense_MutationNAR278C0.39
KIRCchr1742316872Missense_Mutationrs769372865P725L0.08
KIRCchr1742333970Missense_MutationNAY293N0.3
KIRPchr1742329767SilentnovelG373G0.3
KIRPchr1742329768Missense_MutationnovelG373V0.3
LAMLchr1742329751Missense_MutationnovelR379G0.05
LGGchr1742348425Missense_MutationNAR31Q0.33
LIHCchr1742322464Missense_Mutationrs769031989Y640F0.28
LIHCchr17423156223'UTRnovel0.33
LIHCchr1742348434Missense_MutationNAM28K0.45
LIHCchr1742329558Missense_MutationNAH410R0.53
LIHCchr1742322464Missense_Mutationrs769031989Y640F0.06
LIHCchr1742316712Intronnovel0.35
LUADchr1742323312Missense_MutationnovelD566Y0.31
LUADchr1742339319Missense_MutationNAV155M0.24
LUADchr1742338736Missense_MutationNAQ182R0.25
LUADchr1742329411Missense_Mutationrs749583802D427G0.13
LUADchr1742322438Missense_MutationnovelS649P0.07
LUADchr1742329558Missense_MutationNAH410R0.15
LUADchr1742322388SilentNAI665I0.28
LUADchr1742324730SilentnovelT527T0.28
LUADchr1742316898SilentNAT716T0.12
LUADchr1742329555Frame_Shift_DelnovelL411*0.25
LUSCchr1742329588Missense_MutationnovelN400I0.12
LUSCchr1742322457SilentnovelK642K0.05
LUSCchr1742323046Missense_MutationnovelE616Q0.17
LUSCchr1742323004Missense_MutationnovelG630S0.2
LUSCchr1742337825Missense_MutationnovelV195L0.36
LUSCchr1742323040Missense_MutationNAG618R0.08
LUSCchr1742322437Nonsense_MutationNAS649*0.12
OVchr1742329457Missense_MutationnovelT412A0.06
OVchr1742346666Missense_MutationnovelN59I0.1
OVchr1742323607Missense_MutationnovelS540L0.08
OVchr1742324821Missense_MutationnovelP497L0.14
OVchr1742348420Missense_MutationnovelF33I0.04
OVchr17423156803'UTRnovel0.13
OVchr1742322405Missense_MutationnovelM660L0.09
OVchr1742346684Missense_MutationNAA53G0.47
OVchr1742316676Intronnovel0.44
OVchr1742323049Missense_MutationnovelK615E0.63
OVchr1742324751SilentnovelL520L0.32
OVchr1742315920Intronnovel0.09
PAADchr17423157333'UTRrs3743272570.21
PAADchr17423156523'UTRnovel0.19
PAADchr1742316890Missense_MutationnovelS719N0.27
PAADchr1742337846Frame_Shift_DelnovelL188*0.03
PCPGchr1742326162Missense_MutationnovelT440I0.11
PRADchr1742322467Missense_MutationNAP639L0.19
PRADchr1742322430SilentNAA651A0.3
PRADchr1742333961Missense_MutationnovelD296Y0.29
PRADchr1742323066Missense_MutationNAR609T0.16
READchr1742323336Missense_MutationnovelG558S0.29
READchr1742323013Missense_MutationnovelD627N0.44
READchr17423155453'UTRnovel0.31
READchr17423156843'UTRnovel0.27
SARCchr17423147713'UTRnovel0.21
SKCMchr1742324795Missense_MutationNAE506K0.55
SKCMchr1742333717SilentNAR335R0.19
SKCMchr1742348439SilentNAF26F0.49
SKCMchr1742323328Silentrs146817483S560S0.31
SKCMchr1742331525SilentnovelL352L0.18
SKCMchr1742315753Missense_MutationNAP769S0.11
SKCMchr1742346599SilentnovelH81H0.33
SKCMchr1742346600Missense_MutationnovelH81L0.32
SKCMchr1742322488Missense_MutationNAT632I0.18
SKCMchr1742322350Missense_MutationnovelP678L0.64
SKCMchr1742322351Missense_MutationnovelP678S0.65
SKCMchr1742333891Missense_MutationnovelS319N0.46
SKCMchr1742329764Silentrs376080249D374D0.54
SKCMchr1742333901Missense_MutationNAL316I0.65
SKCMchr1742323280SilentNAI576I0.4
SKCMchr1742337775SilentNAD211D0.25
SKCMchr1742316743IntronNA0.28
SKCMchr1742323273Missense_MutationNAL579F0.44
SKCMchr1742316716IntronNA0.29
SKCMchr1742316712IntronNA0.23
SKCMchr1742322471Missense_MutationNAE638K0.08
SKCMchr1742346604Nonsense_MutationNAQ80*0.05
SKCMchr17423157183'UTRnovel0.41
SKCMchr1742324830Missense_MutationNAT494I0.46
SKCMchr1742331515Missense_MutationNAP356S0.23
STADchr1742322402Missense_Mutationrs747639500D661Y0.34
STADchr1742315769Silentrs147202525S763S0.28
STADchr1742324978SilentNAL483L0.21
STADchr1742337536Missense_MutationnovelQ232H0.43
STADchr1742324795Missense_MutationNAE506K0.08
STADchr1742322422Missense_MutationNAI654T0.05
STADchr1742322463Silentrs751536580Y640Y0.05
STADchr1742329582Missense_MutationnovelG402D0.1
STADchr1742337510Missense_MutationNAA241D0.36