EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
25227661Epigenetic silencing of methyl-CpG-binding protein 2 gene affects proliferation, invasion, migration, and apoptosis of human osteosarcoma cells.Tumour Biol2014 DecMeng Gdoi: 10.1007/s13277-014-2336-8
12646234Methyl-CpG-DNA binding proteins in human prostate cancer: expression of CXXC sequence containing MBD1 and repression of MBD2 and MeCP2.Biochem Biophys Res Commun2003 Mar 21Patra SK-
25827305Prognostic values of 5-hmC, 5-mC and TET2 in epithelial ovarian cancer.Arch Gynecol Obstet2015 OctZhang LYdoi: 10.1007/s00404-015-3704-3
27377594Rb silencing mediated by the down-regulation of MeCP2 is involved in cell transformation induced by long-term exposure to hydroquinone.Mol Carcinog2017 FebLiu Ldoi: 10.1002/mc.22523
24531693Chromatin composition alterations and the critical role of MeCP2 for epigenetic silencing of progesterone receptor-B gene in endometrial cancers.Cell Mol Life Sci2014 SepChu Ydoi: 10.1007/s00018-014-1580-9
16331274The methyl-CpG-binding protein MECP2 is required for prostate cancer cell growth.Oncogene2006 Mar 2Bernard D-
26648260Lentivirusmediated knockdown of MeCP2 inhibits the growth of colorectal cancer cells in vitro.Mol Med Rep2016 JanSong Ndoi: 10.3892/mmr.2015.4612
23135915Epigenetic regulation by Z-DNA silencer function controls cancer-associated ADAM-12 expression in breast cancer: cross-talk between MeCP2 and NF1 transcription factor family.Cancer Res2013 Jan 15Ray BKdoi: 10.1158/0008-5472.CAN-12-2601
18666890Silencing of MBD1 and MeCP2 in prostate-cancer-derived PC3 cells produces differential gene expression profiles and cellular phenotypes.Biosci Rep2008 DecYaqinuddin Adoi: 10.1042/BSR20080032.
25705847Genome-Wide DNA Methylation Analysis in Melanoma Reveals the Importance of CpG Methylation in MITF Regulation.J Invest Dermatol2015 JulLauss Mdoi: 10.1038/jid.2015.61
28131747MeCP2 Promotes Gastric Cancer Progression Through Regulating FOXF1/Wnt5a/β-Catenin and MYOD1/Caspase-3 Signaling Pathways.EBioMedicine2017 FebZhao Ldoi: 10.1016/j.ebiom.2017.01.021
28767600MECP2 expression in gastric cancer and its correlation with clinical pathological parameters.Medicine (Baltimore)2017 AugZhang Jdoi: 10.1097/MD.0000000000007691.
28329686Demethylated HSATII DNA and HSATII RNA Foci Sequester PRC1 and MeCP2 into Cancer-Specific Nuclear Bodies.Cell Rep2017 Mar 21Hall LLdoi: 10.1016/j.celrep.2017.02.072.
28100567MeCP2 regulated glycogenes contribute to proliferation and apoptosis of gastric cancer cells.Glycobiology2017 Apr 1Qin Ydoi: 10.1093/glycob/cwx006.
26910839MeCP2 suppresses LIN28A expression via binding to its methylated-CpG islands in pancreatic cancer cells.Oncotarget2016 Mar 22Xu Mdoi: 10.18632/oncotarget.7507.
27166996MECP2 promotes the growth of gastric cancer cells by suppressing miR-338-mediated antiproliferative effect.Oncotarget2016 Jun 7Tong Ddoi: 10.18632/oncotarget.9197.
29869456CpG Island Methylator Phenotype and Methylation of Wnt Pathway Genes Together Predict Survival in Patients with Colorectal Cancer.Yonsei Med J2018 JulKim SHdoi: 10.3349/ymj.2018.59.5.588.
29568890miR-19a/b and MeCP2 repress reciprocally to regulate multidrug resistance in gastric cancer cells.Int J Mol Med2018 JulZhu Fdoi: 10.3892/ijmm.2018.3581
28291253Mecp2-mediated Epigenetic Silencing of miR-137 Contributes to Colorectal Adenoma-Carcinoma Sequence and Tumor Progression via Relieving the Suppression of c-Met.Sci Rep2017 Mar 14Chen Tdoi: 10.1038/srep44543.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchrX154030464Frame_Shift_InsnovelE455Gfs*320.08
ACCchrX154030423Missense_MutationnovelP469S0.24
BLCAchrX154030511SilentnovelA439A0.93
BLCAchrX154032280Missense_MutationnovelE102K0.72
BLCAchrX154031019Missense_MutationnovelR270Q0.96
BLCAchrX154031125Missense_MutationnovelE235K0.3
BRCAchrX154030934Missense_MutationNAE298D0.4
BRCAchrX1540300613'UTRnovel0.17
BRCAchrX154032331Missense_MutationNAR85C0.31
BRCAchrX154030487In_Frame_InsnovelT442_A447dup0.1
BRCAchrX1540284623'UTRnovel0.18
BRCAchrX1540301553'UTRnovel0.52
BRCAchrX1540239953'UTRnovel0.24
BRCAchrX154031354Silentrs61748413T158T0.25
BRCAchrX1540302893'UTRnovel0.19
BRCAchrX154030501Missense_MutationnovelA443P0.2
BRCAchrX1540299513'UTRrs1414976030.14
BRCAchrX154030903Missense_Mutationrs61751444R309W0.16
BRCAchrX154031390Silentrs61748386G146G0.37
BRCAchrX154031430Missense_Mutationrs61748389R133H0.24MBD
CESCchrX154030749Missense_MutationNAS360L0.31
CESCchrX154031162Silentrs61749735V222V0.22
CESCchrX1540232543'UTRnovel0.37
CESCchrX154030844Silentrs61751442L328L0.18
CESCchrX1540234533'UTRnovel0.09
CESCchrX1540248233'UTRnovel0.2
CESCchrX154030791In_Frame_DelnovelS346_K347del0.09
CESCchrX1540268213'UTRnovel0.47
CESCchrX1540235593'UTRnovel0.28
CESCchrX1540247393'UTRnovel0.39
CESCchrX1540256813'UTRnovel0.48
CESCchrX1540283733'UTRnovel0.56
CESCchrX1540300203'UTRnovel0.38
CESCchrX154030499Silentrs782706777A443A0.45
CESCchrX154031223Missense_Mutationrs587783138A202V0.34
CESCchrX154032267Missense_Mutationrs61754457R106Q0.39
CESCchrX1540268673'UTRnovel0.26
CESCchrX1540296033'UTRnovel0.33
CESCchrX1540301173'UTRnovel0.52
COADchrX154030534Frame_Shift_DelnovelE432Afs*30.03
COADchrX154030917Missense_Mutationrs267608550K304R0.19
COADchrX154031402Silentrs61748397F142F0.19
COADchrX1540303433'UTRnovel0.28
COADchrX154030826SilentnovelK334K0.27
COADchrX154030994Silentrs61750248A278A0.55
COADchrX154030768Missense_Mutationrs143876280R354C0.58
COADchrX154030512Missense_Mutationrs782805738A439V0.36
COADchrX154031443Missense_MutationnovelG129R0.12MBD
COADchrX154031409Missense_Mutationrs28934908A140V0.21MBD
COADchrX154030381Missense_MutationnovelE483K0.73
COADchrX154030533Nonsense_MutationnovelE432Vfs*20.05
COADchrX154030482Frame_Shift_DelNAK449Sfs*330.2
ESCAchrX1540240073'UTRnovel0.19
ESCAchrX1540247263'UTRnovel0.27
ESCAchrX1540302813'UTRrs7822133170.24
ESCAchrX154030411Missense_Mutationrs782115829E473Q0.21
ESCAchrX154030382Silentrs76895094T482T0.35
ESCAchrX1540239653'UTRnovel0.67
ESCAchrX1540218893'UTRnovel0.26
ESCAchrX154031120SilentnovelG236G0.2
ESCAchrX1540218643'UTRnovel0.44
ESCAchrX1540221053'UTRrs7825028910.8
ESCAchrX1540259083'UTRnovel0.38
ESCAchrX1540299523'UTRnovel0.82
ESCAchrX1540291413'UTRnovel0.35
GBMchrX154032318Missense_MutationnovelR89H0.36
GBMchrX154030418Missense_MutationNAN470K0.26
GBMchrX154032441Missense_MutationnovelP48Q0.19
GBMchrX154031261SilentnovelG189G0.67
GBMchrX1540303133'UTRnovel0.17
GBMchrX1540302763'UTRnovel0.17
HNSCchrX154031219Silentrs61749722T203T0.42
HNSCchrX154031357SilentnovelF157F0.83
KICHchrX154030987Missense_Mutationrs782239416A281T0.9
KIRCchrX154031435Silentrs61748385A131A0.16
KIRCchrX154032366Missense_MutationNAA73V0.08
KIRPchrX1540922615'UTRnovel0.84
LAMLchrX154032532Frame_Shift_InsnovelL18Ffs*130.44
LGGchrX154032323SilentNAI87I0.83
LIHCchrX154031355Missense_Mutationrs28934906T158M0.86
LIHCchrX154030432Missense_MutationNAM466L0.41
LUADchrX154031010Missense_MutationNAG273V0.3
LUADchrX154032435Missense_MutationnovelA50G0.09
LUADchrX154032486Missense_MutationnovelK33T0.05
LUADchrX154032375Missense_MutationnovelS70Y0.52
LUADchrX154032358Missense_MutationnovelE76K0.22
LUADchrX154030987Missense_MutationnovelA281S0.17
LUADchrX154030919Missense_Mutationrs61751439I303M0.2
LUADchrX154030803Missense_MutationNAP342L0.16
LUADchrX1540923005'UTRnovel0.15
LUADchrX1540976365'UTRnovel0.44
LUADchrX1540976375'UTRnovel0.46
LUADchrX154032379Missense_MutationnovelG69C0.22
LUADchrX154031002Missense_MutationnovelV276L0.36
LUADchrX154032495Missense_MutationnovelK30T0.08
LUSCchrX154030919Missense_Mutationrs61751439I303M0.28
LUSCchrX154030848Missense_MutationNAT327N0.36
LUSCchrX154032225Missense_MutationNAY120C0.3MBD
LUSCchrX154031064Missense_MutationnovelR255Q0.24
LUSCchrX1540922665'UTRnovel0.2
OVchrX154032342In_Frame_DelnovelA73_P81del0.31
OVchrX154030631SilentnovelP399P0.64
OVchrX154030608Frame_Shift_DelnovelD407Afs*20.1
OVchrX154032244Missense_MutationnovelG114R0.28MBD
OVchrX1540302713'UTRnovel0.05
OVchrX154031032In_Frame_InsnovelP265_K266insD0.05
PAADchrX1540303143'UTRnovel0.07
PAADchrX154030848Missense_MutationnovelT327I0.03
PCPGchrX154031280Missense_MutationnovelG183E0.18
PRADchrX154032531Missense_MutationnovelL18P0.81
READchrX154031355Missense_Mutationrs28934906T158M0.55
SARCchrX1540301513'UTRnovel0.33
SARCchrX1540268803'UTRnovel0.33
SARCchrX1540238743'UTRnovel1
SKCMchrX154031179Missense_Mutationrs786205894P217S0.36
SKCMchrX154030678Missense_Mutationrs373116070P384S0.18
SKCMchrX154030863Missense_Mutationrs61751450P322L0.62
SKCMchrX154031402Silentrs61748397F142F0.21
SKCMchrX1540301773'UTRnovel0.18
SKCMchrX154031040Missense_Mutationrs782576004A263V0.4
SKCMchrX154031255Silentrs61749710P191P0.98
SKCMchrX154031256Missense_MutationnovelP191L0.98
SKCMchrX154030625Silentrs782230851S401S0.72
SKCMchrX154030744Missense_MutationNAP362S0.41
STADchrX154031302Missense_Mutationrs186663314P176S0.48
STADchrX154032352Missense_MutationnovelS78A0.26
STADchrX154030640Silentrs781816931S396S0.81
STADchrX154030455Missense_Mutationrs185957513R458H0.21
STADchrX154032549Missense_MutationNAK12R0.11
STADchrX1540976435'UTRnovel0.5
STADchrX154032529Missense_MutationNAQ19E0.22
STADchrX154030455Missense_Mutationrs185957513R458H0.14
STADchrX154032268Missense_Mutationrs28934907R106W0.44
STADchrX1540302563'UTRnovel0.25
STADchrX1540302453'UTRrs2676083420.77
STADchrX154030372Missense_MutationNAS486R0.73
STADchrX154030606SilentNAL408L0.09
STADchrX154031117Frame_Shift_Insrs267608517G238Wfs*210.18
THCAchrX154031449Missense_MutationNAP127S0.09MBD
THYMchrX154031377Missense_MutationnovelD151N0.17MBD
THYMchrX154032246Missense_Mutationrs781871640S113F0.58MBD
THYMchrX1540218643'UTRnovel0.08
UCECchrX1540232133'UTRnovel0.1
UCECchrX154032334Missense_MutationNAR84W0.34
UCECchrX154030958Silentrs587781032E290E0.35
UCECchrX1540237153'UTRnovel0.36
UCECchrX1540282813'UTRnovel0.1
UCECchrX1540250933'UTRnovel0.15
UCECchrX154031156Missense_MutationnovelM224I0.34
UCECchrX1540284203'UTRnovel0.17
UCECchrX1540300233'UTRnovel0.25
UCECchrX1540231003'UTRnovel0.14
UCECchrX1540240973'UTRnovel0.3
UCECchrX1540301643'UTRnovel0.27
UCECchrX154030610Missense_MutationnovelQ406H0.29
UCECchrX1540257563'UTRnovel0.26
UCECchrX154030832Silentrs148744894S332S0.14
UCECchrX1540242013'UTRnovel0.27
UCECchrX1540301423'UTRnovel0.29
UCECchrX154030912Missense_Mutationrs28935468R306C0.34
UCECchrX154032246Missense_MutationnovelS113Y0.41MBD
UCECchrX1540248793'UTRrs2021391040.22
UCECchrX1540302753'UTRrs626216720.35
UCECchrX154031288SilentnovelK180K0.12
UCECchrX1540263823'UTRnovel0.35
UCECchrX1540300393'UTRrs626216730.36
UCECchrX1540248533'UTRnovel0.18
UCECchrX1540282973'UTRnovel0.23
UCECchrX1540302453'UTRnovel0.12
UCECchrX154031401Missense_MutationNAE143K0.22MBD
UCECchrX1540218643'UTRnovel0.36
UCECchrX1540247353'UTRrs7818679930.39
UCECchrX154030397SilentNAS477S0.14
UCECchrX154030547Silentrs374900442D427D0.29
UCECchrX1540249243'UTRrs7821882340.44
UCECchrX154030846Missense_MutationnovelL328I0.21
UCECchrX154031326Nonsense_Mutationrs61748421R168*0.15
UCECchrX1540300013'UTRnovel0.13
UCECchrX1540230363'UTRnovel0.57
UCECchrX1540302543'UTRnovel0.58
UCECchrX1540240963'UTRrs7819898000.27
UCECchrX1540245953'UTRnovel0.57
UCECchrX1540260173'UTRnovel0.4
UCECchrX1540280923'UTRnovel0.39
UCECchrX1540219953'UTRnovel0.09
UCECchrX1540267833'UTRnovel0.13
UCECchrX1540232063'UTRnovel0.3
UCECchrX1540291313'UTRnovel0.3
UCECchrX1540302503'UTRnovel0.18
UCECchrX154032470SilentnovelE38E0.21
UCECchrX1540250863'UTRnovel0.26
UCECchrX1540271273'UTRnovel0.26
UCECchrX154032287SilentnovelT99T0.28
UCECchrX1540268803'UTRrs7821601890.22
UCECchrX1540218643'UTRnovel0.47
UCECchrX1540247263'UTRnovel0.19
UCECchrX1540230163'UTRnovel0.39
UCECchrX1540242563'UTRnovel0.23
UCECchrX1540267753'UTRnovel0.3
UCECchrX1540268943'UTRnovel0.38
UCECchrX1540282453'UTRnovel0.23
UCECchrX1540302443'UTRrs7822254900.64
UCECchrX1540267763'UTRnovel0.3
UCECchrX1540239453'UTRnovel0.19
UCECchrX1540219613'UTRnovel0.42
UCECchrX1540246593'UTRnovel0.42
UCECchrX1540264033'UTRnovel0.36
UCECchrX154030574Missense_MutationNAM418I0.46
UCECchrX154031401Missense_MutationNAE143K0.18MBD
UCECchrX1540302243'UTRnovel0.44
UCECchrX154030911Missense_Mutationrs61751443R306H0.36
UCECchrX1540299263'UTRnovel0.19
UCECchrX1540296223'UTRnovel0.6
UCECchrX1540302233'UTRnovel0.5
UCECchrX154030739Missense_MutationnovelK363N0.55
UCECchrX1540218143'UTRnovel0.43
UCECchrX1540218643'UTRnovel0.6
UCECchrX1540247263'UTRnovel0.41
UCECchrX1540218643'UTRnovel0.17
UCECchrX1540219993'UTRnovel0.36
UCECchrX1540249483'UTRnovel0.16
UCECchrX1540259133'UTRnovel0.28
UCECchrX1540279463'UTRnovel0.29
UCECchrX1540282993'UTRnovel0.44
UCECchrX1540291053'UTRnovel0.3
UCECchrX154030381Missense_MutationnovelE483K0.39
UCECchrX1540218643'UTRnovel0.18
UCECchrX1540247263'UTRnovel0.27
UCECchrX1540259013'UTRnovel0.27
UCECchrX1540264453'UTRnovel0.35
UCECchrX1540284373'UTRnovel0.3
UCECchrX154030989Missense_MutationnovelA280V0.09
UCECchrX154031204Missense_MutationnovelQ208H0.38
UCECchrX1540247263'UTRnovel0.36
UCECchrX1540299743'UTRrs2676083610.2
UCECchrX1540302323'UTRnovel0.24
UCECchrX154030501Missense_Mutationrs193922677A443T0.44
UCECchrX154031065Nonsense_Mutationrs61749721R255*0.44
UCECchrX154032502Missense_MutationnovelF28L0.13
UCECchrX1540258463'UTRnovel0.42
UCECchrX154030993Missense_Mutationrs371234586A279T0.33
UCECchrX154031402Silentrs61748397F142F0.39
UCECchrX1540280523'UTRnovel0.28
UCECchrX1540295733'UTRnovel0.32
UCECchrX154032488Missense_MutationnovelK32N0.39
UCECchrX1540247263'UTRnovel0.3
UCECchrX1540248233'UTRnovel0.46
UCECchrX154031065Nonsense_Mutationrs61749721R255*0.61
UCECchrX1540232603'UTRnovel0.32
UCECchrX1540234003'UTRnovel0.38
UCECchrX1540240463'UTRnovel0.31
UCECchrX1540266223'UTRnovel0.45
UCECchrX1540267753'UTRnovel0.42
UCECchrX1540271273'UTRnovel0.47
UCECchrX1540280683'UTRnovel0.27
UCECchrX1540292493'UTRrs1867745700.39
UCECchrX154031408Silentrs782082759A140A0.5
UCECchrX1540238453'UTRnovel0.3
UCECchrX154031402Silentrs61748397F142F0.56
UCECchrX154031133Frame_Shift_Delrs63260260G232Afs*160.47
UCECchrX1540302233'UTRnovel0.15
UCECchrX1540248723'UTRnovel0.17
UCECchrX154030863Missense_Mutationrs61751450P322L0.35
UCECchrX154030511Silentrs146632223A439A0.32
UCECchrX1540247253'UTRnovel0.49
UCECchrX1540247263'UTRnovel0.41
UCECchrX1540260073'UTRnovel0.31
UCECchrX1540292483'UTRnovel0.44
UCECchrX1540299463'UTRnovel0.32
UCECchrX154032557Missense_MutationNAR9S0.16
UCECchrX154092191Missense_MutationnovelG7W0.12
UCECchrX154031073Missense_MutationNAG252D0.31
UCECchrX1540247353'UTRrs7818679930.4
UCECchrX1540303073'UTRnovel0.37
UCECchrX154032331Missense_MutationNAR85C0.19
UCECchrX1540263363'UTRnovel0.57
UCECchrX1540922125'UTRnovel0.24
UCECchrX1540240173'UTRnovel0.33
UCECchrX1540303073'UTRnovel0.31
UCECchrX1540259503'UTRnovel0.52
UCECchrX1540294463'UTRnovel0.31
UCECchrX1540240693'UTRnovel0.31
UCECchrX1540247263'UTRnovel0.13
UCECchrX1540299553'UTRnovel0.38
UCECchrX154030505Silentrs781964746A441A0.32
UCECchrX1540263653'UTRnovel0.36
UCECchrX154030814SilentNAT338T0.28
UCECchrX1540245903'UTRnovel0.16
UCECchrX1540219953'UTRnovel0.25
UCECchrX1540235043'UTRnovel0.36
UCECchrX1540264273'UTRnovel0.33
UCECchrX154031390Silentrs61748386G146G0.41
UCECchrX1540247353'UTRrs7818679930.26
UCECchrX1540282073'UTRnovel0.35
UCECchrX154030501Missense_Mutationrs193922677A443T0.33
UCSchrX1540303543'UTRrs7823348440.41

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CESCAMP0.19323.2002e-05
DLBCAMP0.14580.24013
ESCAAMP0.27170.18371
HNSCAMP0.21070.0095371
KIRCAMP0.04360.12739
LIHCAMP0.15410.011319
LUSCAMP0.17760.08275
OVAMP0.31432.176e-06
PAADAMP0.07610.041079
READAMP0.15150.14805
STADAMP0.11110.0021069
TGCTDEL0.06670.08422
THCADEL0.0020.21991
UCECAMP0.09280.010288
UCSDEL0.28570.063955

Survival Analysis
CancerP-value Q-value
KIRC0.0001

Kaplan-Meier Survival Analysis

SARC0.012

Kaplan-Meier Survival Analysis

MESO0.018

Kaplan-Meier Survival Analysis

BRCA0.014

Kaplan-Meier Survival Analysis

COAD0.032

Kaplan-Meier Survival Analysis

PAAD0.0018

Kaplan-Meier Survival Analysis

PCPG0.038

Kaplan-Meier Survival Analysis

CESC0.001

Kaplan-Meier Survival Analysis

UCEC0.00071

Kaplan-Meier Survival Analysis

LUAD0.003

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000169057 (Gene tree)
Gene ID
4204
Gene Symbol
MECP2
Alias
RTT|MRX16|MRX79
Full Name
methyl-CpG binding protein 2
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
115,531 bases
Position
chrX:154,021,573-154,137,103
Accession
6990
RBP type
canonical RBP
Summary
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of cognitive disability in females. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000479736MBDPF01429.194.9e-1711
ENSP00000492871MBDPF01429.191.2e-1611
ENSP00000484470MBDPF01429.191.6e-1611
ENSP00000301948MBDPF01429.192.7e-1611
ENSP00000395535MBDPF01429.192.8e-1611
ENSP00000486978MBDPF01429.196.5e-1411
ENSP00000384865MBDPF01429.197.4e-1411
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
17028371The molecular pathology of Rett syndrome: synopsis and update.Neuromolecular Med2006Akbarian S-
16251272Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2.Proc Natl Acad Sci U S A2005 Dec 6Young JI-
27732849MECP2 Is Post-transcriptionally Regulated during Human Neurodevelopment by Combinatorial Action of RNA-Binding Proteins and miRNAs.Cell Rep2016 Oct 11Rodrigues DCdoi: 10.1016/j.celrep.2016.09.049.
30136864Gordon H. Dixon's trace in my personal career and the quantic jump experienced in regulatory information.Syst Biol Reprod Med2018 DecMezquita-Pla Jdoi: 10.1080/19396368.2018.1503752
18666890Silencing of MBD1 and MeCP2 in prostate-cancer-derived PC3 cells produces differential gene expression profiles and cellular phenotypes.Biosci Rep2008 DecYaqinuddin Adoi: 10.1042/BSR20080032.
25837375The alternative role of DNA methylation in splicing regulation.Trends Genet2015 MayLev Maor Gdoi: 10.1016/j.tig.2015.03.002
28480880Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment.Nat Commun2017 May 8Wong JJdoi: 10.1038/ncomms15134.
19812320Synaptic circuit abnormalities of motor-frontal layer 2/3 pyramidal neurons in an RNA interference model of methyl-CpG-binding protein 2 deficiency.J Neurosci2009 Oct 7Wood Ldoi: 10.1523/JNEUROSCI.3321-09.2009.
17988628The story of Rett syndrome: from clinic to neurobiology.Neuron2007 Nov 8Chahrour M-
28352654NET silencing by let-7i in postural tachycardia syndrome.JCI Insight2017 Mar 23Khan AWdoi: 10.1172/jci.insight.90183.
25444166Brain-derived neurotrophic factor epigenetic modifications associated with schizophrenia-like phenotype induced by prenatal stress in mice.Biol Psychiatry2015 Mar 15Dong Edoi: 10.1016/j.biopsych.2014.08.012
28416772DNA methylation of METTL7A gene body regulates its transcriptional level in thyroid cancer.Oncotarget2017 May 23Zhou Sdoi: 10.18632/oncotarget.16147.
29282321A mixed modality approach towards Xi reactivation for Rett syndrome and other X-linked disorders.Proc Natl Acad Sci U S A2018 Jan 23Carrette LLGdoi: 10.1073/pnas.1715124115
29409936Epigenetic regulation by CpG methylation splits strong from retarded IFNγ-induced IL-18BP in epithelial versus monocytic cells.Biochim Biophys Acta Gene Regul Mech2018 MarBachmann Mdoi: 10.1016/j.bbagrm.2018.01.020
30008886DNA methylation contributes to silencing the expression of linc00086 in gastric cancer.Oncol Lett2018 AugYang Ydoi: 10.3892/ol.2018.8868
16052033Specific binding of the methyl binding domain protein 2 at the BRCA1-NBR2 locus.Nucleic Acids Res2005 Jul 28Auriol E-
17133344Multiple binding of methyl-CpG and polycomb proteins in long-term gene silencing events.J Cell Physiol2007 MarMatarazzo MR-
27965390DNA methylation in the gene body influences MeCP2-mediated gene repression.Proc Natl Acad Sci U S A2016 Dec 27Kinde Bdoi: 10.1073/pnas.1618737114
28523538MeCP2, A Modulator of Neuronal Chromatin Organization Involved in Rett Syndrome.Adv Exp Med Biol2017Martinez de Paz Adoi: 10.1007/978-3-319-53889-1_1.
29019980Radically truncated MeCP2 rescues Rett syndrome-like neurological defects.Nature2017 Oct 19Tillotson Rdoi: 10.1038/nature24058
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000622433MECP2-2131071-ENSP00000484470324 (aa)-A0A087X1U4
ENST00000637917MECP2-224159-ENSP0000048984753 (aa)-A0A1B0GTV0
ENST00000631210MECP2-220490--- (aa)--
ENST00000626422MECP2-215835--- (aa)--
ENST00000453960MECP2-2051729-ENSP00000395535498 (aa)-P51608
ENST00000630151MECP2-219322-ENSP0000048608941 (aa)-A0A0D9SEX1
ENST00000460227MECP2-2061298--- (aa)--
ENST00000415944MECP2-204413-ENSP0000041626749 (aa)-C9JH89
ENST00000637467MECP2-221101--- (aa)--
ENST00000611468MECP2-212603-ENSP00000479736168 (aa)-A0A087WVW7
ENST00000628176MECP2-2171712-ENSP00000486978172 (aa)-A0A0D9SFX7
ENST00000303391MECP2-20110505XM_006724819ENSP00000301948486 (aa)XP_006724882P51608
ENST00000407218MECP2-2031174-ENSP00000384865184 (aa)-B5MCB4
ENST00000627864MECP2-216581--- (aa)--
ENST00000369957MECP2-202784-ENSP0000035897337 (aa)-H7BY72
ENST00000637533MECP2-222140--- (aa)--
ENST00000488293MECP2-2101198--- (aa)--
ENST00000637791MECP2-223101--- (aa)--
ENST00000481807MECP2-208436--- (aa)--
ENST00000625300MECP2-214350--- (aa)--
ENST00000463644MECP2-2071088--- (aa)--
ENST00000486506MECP2-2092907--- (aa)--
ENST00000638041MECP2-225100--- (aa)--
ENST00000640414MECP2-226897-ENSP00000492871271 (aa)-I6LM39
ENST00000629277MECP2-2182558--- (aa)--
ENST00000496908MECP2-211342--- (aa)--
Gene Model
Click here to download ENSG00000169057's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000169057Child Development Disorders, Pervasive4.8814100E-005-
ENSG00000169057Child Development Disorders, Pervasive5.9476100E-005-
ENSG00000169057Child Development Disorders, Pervasive4.8814100E-005-
ENSG00000169057Child Development Disorders, Pervasive4.6750400E-006-
ENSG00000169057Child Development Disorders, Pervasive2.5642600E-005-
ENSG00000169057Child Development Disorders, Pervasive3.4092400E-006-
ENSG00000169057Child Development Disorders, Pervasive2.8884900E-006-
ENSG00000169057Child Development Disorders, Pervasive1.0967600E-006-
ENSG00000169057Child Development Disorders, Pervasive1.0401500E-005-
ENSG00000169057Child Development Disorders, Pervasive4.7229200E-006-
ENSG00000169057Child Development Disorders, Pervasive4.6750400E-006-
ENSG00000169057Child Development Disorders, Pervasive2.5642600E-005-
ENSG00000169057Child Development Disorders, Pervasive3.4092400E-006-
ENSG00000169057Child Development Disorders, Pervasive2.8884900E-006-
ENSG00000169057Child Development Disorders, Pervasive1.0967600E-006-
ENSG00000169057Child Development Disorders, Pervasive1.0401500E-005-
ENSG00000169057Child Development Disorders, Pervasive4.7229200E-006-
ENSG00000169057Child Development Disorders, Pervasive3.3854300E-005-
ENSG00000169057Child Development Disorders, Pervasive2.9114700E-005-
ENSG00000169057Child Development Disorders, Pervasive1.3535900E-005-
ENSG00000169057Child Development Disorders, Pervasive3.5188000E-005-
ENSG00000169057Child Development Disorders, Pervasive3.3854300E-005-
ENSG00000169057Child Development Disorders, Pervasive2.9114700E-005-
ENSG00000169057Child Development Disorders, Pervasive1.3535900E-005-
ENSG00000169057Child Development Disorders, Pervasive3.5188000E-005-
ENSG00000169057Lupus Erythematosus, Systemic2E-1526502338
ENSG00000169057Arthritis, Rheumatoid5E-1624390342
ENSG00000169057Arthritis, Rheumatoid3E-1224390342
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000169057rs5987194X154036016CRheumatoid arthritis24390342[1.12-1.20]1.16EFO_0000685
ENSG00000169057rs5987194X154036016CRheumatoid arthritis24390342[1.12-1.21]1.16EFO_0000685
ENSG00000169057rs3027933X154033423?Non-albumin protein levels29403010[0.017-0.034] unit decrease novel0.02511EFO_0004568
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000169057's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000169057MECP29362.805ENSAPOG00000002652mecp27152.660Acanthochromis_polyacanthus
ENSG00000169057MECP298100.000ENSAMEG00000018448MECP29992.577Ailuropoda_melanoleuca
ENSG00000169057MECP25484.615ENSAPEG00000023997mecp25158.661Amphiprion_percula
ENSG00000169057MECP25476.027ENSATEG00000019486mecp25558.586Anabas_testudineus
ENSG00000169057MECP29185.621ENSACAG00000012519MECP29068.432Anolis_carolinensis
ENSG00000169057MECP210098.837ENSANAG00000019603MECP210098.837Aotus_nancymaae
ENSG00000169057MECP27766.197ENSAMXG00000039189mecp25056.522Astyanax_mexicanus
ENSG00000169057MECP298100.000ENSBTAG00000047855MECP210095.473Bos_taurus
ENSG00000169057MECP210099.794ENSCJAG00000016796MECP210099.794Callithrix_jacchus
ENSG00000169057MECP298100.000ENSCAFG00000019440MECP210096.586Canis_familiaris
ENSG00000169057MECP298100.000ENSCAFG00020022079MECP210096.502Canis_lupus_dingo
ENSG00000169057MECP298100.000ENSCHIG00000023071MECP210095.218Capra_hircus
ENSG00000169057MECP298100.000ENSTSYG00000007420MECP210096.708Carlito_syrichta
ENSG00000169057MECP298100.000ENSCAPG00000012930MECP29595.756Cavia_aperea
ENSG00000169057MECP298100.000ENSCPOG00000012579MECP210090.675Cavia_porcellus
ENSG00000169057MECP298100.000ENSCCAG00000037407MECP210097.710Cebus_capucinus
ENSG00000169057MECP210099.799ENSCATG00000017038MECP210099.799Cercocebus_atys
ENSG00000169057MECP298100.000ENSCLAG00000001648MECP210094.033Chinchilla_lanigera
ENSG00000169057MECP29999.582ENSCSAG00000006798MECP210099.582Chlorocebus_sabaeus
ENSG00000169057MECP29877.108ENSCPBG00000006868-6474.699Chrysemys_picta_bellii
ENSG00000169057MECP210099.794ENSCANG00000028728MECP210099.794Colobus_angolensis_palliatus
ENSG00000169057MECP298100.000ENSCGRG00001017650Mecp210096.115Cricetulus_griseus_chok1gshd
ENSG00000169057MECP210097.561ENSCGRG00000005191-10091.860Cricetulus_griseus_crigri
ENSG00000169057MECP29947.177ENSDARG00000014218mecp26060.125Danio_rerio
ENSG00000169057MECP298100.000ENSDNOG00000013419MECP29392.506Dasypus_novemcinctus
ENSG00000169057MECP298100.000ENSDORG00000014978Mecp210096.600Dipodomys_ordii
ENSG00000169057MECP29784.144ENSETEG00000009825-9683.682Echinops_telfairi
ENSG00000169057MECP26555.963ENSEBUG00000007592-8455.963Eptatretus_burgeri
ENSG00000169057MECP298100.000ENSEASG00005019188MECP210096.988Equus_asinus_asinus
ENSG00000169057MECP29594.512ENSECAG00000018208MECP28794.512Equus_caballus
ENSG00000169057MECP27794.961ENSEEUG00000003070-7894.961Erinaceus_europaeus
ENSG00000169057MECP298100.000ENSFCAG00000011389MECP210096.586Felis_catus
ENSG00000169057MECP210092.442ENSFDAG00000002308-9295.597Fukomys_damarensis
ENSG00000169057MECP25543.011ENSFHEG00000001333-8042.056Fundulus_heteroclitus
ENSG00000169057MECP29275.974ENSGALG00000047963MECP26892.958Gallus_gallus
ENSG00000169057MECP25187.059ENSGACG00000000798mecp25657.358Gasterosteus_aculeatus
ENSG00000169057MECP29481.646ENSGAGG00000004728MECP29463.692Gopherus_agassizii
ENSG00000169057MECP2100100.000ENSGGOG00000042467MECP2100100.000Gorilla_gorilla
ENSG00000169057MECP29859.880ENSHBUG00000020716-6870.161Haplochromis_burtoni
ENSG00000169057MECP298100.000ENSHGLG00000000899MECP210088.525Heterocephalus_glaber_female
ENSG00000169057MECP210092.442ENSHGLG00100004233-9294.969Heterocephalus_glaber_male
ENSG00000169057MECP27469.951ENSIPUG00000013019mecp25064.130Ictalurus_punctatus
ENSG00000169057MECP210098.765ENSSTOG00000006094MECP210098.765Ictidomys_tridecemlineatus
ENSG00000169057MECP298100.000ENSJJAG00000022463Mecp210096.296Jaculus_jaculus
ENSG00000169057MECP29290.476ENSLACG00000011281MECP29067.411Latimeria_chalumnae
ENSG00000169057MECP29471.779ENSLOCG00000014725mecp210053.191Lepisosteus_oculatus
ENSG00000169057MECP298100.000ENSLAFG00000016292MECP210092.034Loxodonta_africana
ENSG00000169057MECP210099.794ENSMFAG00000033178MECP210099.794Macaca_fascicularis
ENSG00000169057MECP210099.457ENSMMUG00000018704MECP210099.457Macaca_mulatta
ENSG00000169057MECP210099.799ENSMNEG00000017455MECP210099.799Macaca_nemestrina
ENSG00000169057MECP210099.794ENSMLEG00000032763MECP210099.794Mandrillus_leucophaeus
ENSG00000169057MECP298100.000ENSMAUG00000018195Mecp210094.888Mesocricetus_auratus
ENSG00000169057MECP210098.152ENSMICG00000005149MECP210098.152Microcebus_murinus
ENSG00000169057MECP298100.000ENSMOCG00000001329Mecp210095.092Microtus_ochrogaster
ENSG00000169057MECP26872.807ENSMMOG00000009875mecp25184.270Mola_mola
ENSG00000169057MECP298100.000ENSMODG00000011643MECP29782.305Monodelphis_domestica
ENSG00000169057MECP26864.324ENSMALG00000014247mecp25361.455Monopterus_albus
ENSG00000169057MECP298100.000MGP_CAROLIEiJ_G0033170Mecp210094.856Mus_caroli
ENSG00000169057MECP298100.000ENSMUSG00000031393Mecp210094.444Mus_musculus
ENSG00000169057MECP298100.000MGP_PahariEiJ_G0031713Mecp210094.856Mus_pahari
ENSG00000169057MECP298100.000MGP_SPRETEiJ_G0034325Mecp210094.856Mus_spretus
ENSG00000169057MECP298100.000ENSMPUG00000009072MECP210093.210Mustela_putorius_furo
ENSG00000169057MECP298100.000ENSMLUG00000014297MECP210094.617Myotis_lucifugus
ENSG00000169057MECP298100.000ENSNGAG00000009171Mecp210096.393Nannospalax_galili
ENSG00000169057MECP26574.312ENSNBRG00000008411mecp25257.288Neolamprologus_brichardi
ENSG00000169057MECP292100.000ENSNLEG00000013783-100100.000Nomascus_leucogenys
ENSG00000169057MECP298100.000ENSMEUG00000002761MECP29682.822Notamacropus_eugenii
ENSG00000169057MECP298100.000ENSODEG00000004523MECP210089.442Octodon_degus
ENSG00000169057MECP26574.312ENSONIG00000000809mecp26361.224Oreochromis_niloticus
ENSG00000169057MECP29192.810ENSOANG00000011024MECP29282.558Ornithorhynchus_anatinus
ENSG00000169057MECP298100.000ENSOCUG00000013147MECP29697.699Oryctolagus_cuniculus
ENSG00000169057MECP298100.000ENSOGAG00000015115MECP210097.737Otolemur_garnettii
ENSG00000169057MECP298100.000ENSOARG00000005806MECP210097.321Ovis_aries
ENSG00000169057MECP2100100.000ENSPPAG00000034020MECP2100100.000Pan_paniscus
ENSG00000169057MECP298100.000ENSPPRG00000004602MECP210096.586Panthera_pardus
ENSG00000169057MECP27991.589ENSPTIG00000002389-9692.381Panthera_tigris_altaica
ENSG00000169057MECP298100.000ENSPTRG00000044429-98100.000Pan_troglodytes
ENSG00000169057MECP2100100.000ENSPTRG00000048003MECP2100100.000Pan_troglodytes
ENSG00000169057MECP210099.598ENSPANG00000011691MECP210099.598Papio_anubis
ENSG00000169057MECP28965.863ENSPKIG00000023979mecp26258.610Paramormyrops_kingsleyae
ENSG00000169057MECP29482.911ENSPSIG00000002254MECP29978.505Pelodiscus_sinensis
ENSG00000169057MECP28565.517ENSPMGG00000017341-6671.667Periophthalmus_magnuspinnatus
ENSG00000169057MECP298100.000ENSPEMG00000015115Mecp210095.501Peromyscus_maniculatus_bairdii
ENSG00000169057MECP298100.000ENSPCIG00000016390MECP210082.834Phascolarctos_cinereus
ENSG00000169057MECP25286.207ENSPFOG00000002307mecp25159.790Poecilia_formosa
ENSG00000169057MECP298100.000ENSPPYG00000020866-8898.728Pongo_abelii
ENSG00000169057MECP29792.373ENSPCAG00000011826MECP29691.824Procavia_capensis
ENSG00000169057MECP210098.196ENSPCOG00000024848MECP210098.196Propithecus_coquereli
ENSG00000169057MECP27497.810ENSPVAG00000000472MECP26997.414Pteropus_vampyrus
ENSG00000169057MECP27368.657ENSPNAG00000024721mecp25061.702Pygocentrus_nattereri
ENSG00000169057MECP298100.000ENSRNOG00000056659Mecp210093.522Rattus_norvegicus
ENSG00000169057MECP210099.588ENSRBIG00000042958MECP210099.588Rhinopithecus_bieti
ENSG00000169057MECP210099.588ENSRROG00000044659MECP210099.588Rhinopithecus_roxellana
ENSG00000169057MECP210099.177ENSSBOG00000024999MECP210099.177Saimiri_boliviensis_boliviensis
ENSG00000169057MECP298100.000ENSSHAG00000007851MECP210081.964Sarcophilus_harrisii
ENSG00000169057MECP26377.193ENSSFOG00015001650mecp27370.430Scleropages_formosus
ENSG00000169057MECP298100.000ENSSARG00000012925MECP210090.776Sorex_araneus
ENSG00000169057MECP298100.000ENSSSCG00000034742MECP29988.660Sus_scrofa
ENSG00000169057MECP26672.067ENSTRUG00000006419mecp26160.073Takifugu_rubripes
ENSG00000169057MECP26964.921ENSTNIG00000005114mecp29849.195Tetraodon_nigroviridis
ENSG00000169057MECP298100.000ENSTTRG00000004653MECP29695.388Tursiops_truncatus
ENSG00000169057MECP298100.000ENSUAMG00000020446MECP29989.655Ursus_americanus
ENSG00000169057MECP210097.561ENSUMAG00000020747-10095.349Ursus_maritimus
ENSG00000169057MECP298100.000ENSVVUG00000029591MECP210096.708Vulpes_vulpes
ENSG00000169057MECP28790.476ENSXETG00000014242mecp210064.826Xenopus_tropicalis
ENSG00000169057MECP27269.072ENSXCOG00000016461mecp25761.905Xiphophorus_couchianus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000122negative regulation of transcription by RNA polymerase II21873635.IBAProcess
GO:0000785chromatin21873635.IBAComponent
GO:0000792heterochromatin21873635.IBAComponent
GO:0000792heterochromatin11441023.IDAComponent
GO:0001227DNA-binding transcription repressor activity, RNA polymerase II-specific-IEAFunction
GO:0001662behavioral fear response-IEAProcess
GO:0001666response to hypoxia-IEAProcess
GO:0001964startle response-IEAProcess
GO:0001976neurological system process involved in regulation of systemic arterial blood pressure-IEAProcess
GO:0002087regulation of respiratory gaseous exchange by neurological system process-IEAProcess
GO:0003677DNA binding21873635.IBAFunction
GO:0003714transcription corepressor activity10773092.TASFunction
GO:0003723RNA binding22658674.HDAFunction
GO:0003729mRNA binding-IEAFunction
GO:0005515protein binding15696166.19820693.23770565.25609649.IPIFunction
GO:0005615extracellular space22664934.HDAComponent
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus11441023.21782149.IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005739mitochondrion-IEAComponent
GO:0005813centrosome25527496.IMPComponent
GO:0005829cytosol21873635.IBAComponent
GO:0006020inositol metabolic process-IEAProcess
GO:0006122mitochondrial electron transport, ubiquinol to cytochrome c-IEAProcess
GO:0006342chromatin silencing-IEAProcess
GO:0006349regulation of gene expression by genetic imprinting-IEAProcess
GO:0006367transcription initiation from RNA polymerase II promoter-TASProcess
GO:0006541glutamine metabolic process-IEAProcess
GO:0006576cellular biogenic amine metabolic process-IEAProcess
GO:0007052mitotic spindle organization25527496.IMPProcess
GO:0007416synapse assembly-IEAProcess
GO:0007585respiratory gaseous exchange-IEAProcess
GO:0007616long-term memory-IEAProcess
GO:0008104protein localization-IEAProcess
GO:0008134transcription factor binding-IEAFunction
GO:0008211glucocorticoid metabolic process-IEAProcess
GO:0008284positive regulation of cell proliferation25527496.IMPProcess
GO:0008327methyl-CpG binding21873635.IBAFunction
GO:0008344adult locomotory behavior-IEAProcess
GO:0008542visual learning-IEAProcess
GO:0009314response to radiation21873635.IBAProcess
GO:0009405pathogenesis-IEAProcess
GO:0009791post-embryonic development-IEAProcess
GO:0010385double-stranded methylated DNA binding21873635.IBAFunction
GO:0010385double-stranded methylated DNA binding17296936.IMPFunction
GO:0010629negative regulation of gene expression23960241.IDAProcess
GO:0010971positive regulation of G2/M transition of mitotic cell cycle25527496.IMPProcess
GO:0016358dendrite development-IEAProcess
GO:0016525negative regulation of angiogenesis23960241.IMPProcess
GO:0016571histone methylation-IEAProcess
GO:0016573histone acetylation-IEAProcess
GO:0019230proprioception-IEAProcess
GO:0019233sensory perception of pain-IEAProcess
GO:0019904protein domain specific binding11441023.IPIFunction
GO:0021549cerebellum development-IEAProcess
GO:0021591ventricular system development-IEAProcess
GO:0031061negative regulation of histone methylation-IEAProcess
GO:0032048cardiolipin metabolic process-IEAProcess
GO:0035067negative regulation of histone acetylation-IEAProcess
GO:0035176social behavior-IEAProcess
GO:0035197siRNA binding-IEAFunction
GO:0042551neuron maturation-IEAProcess
GO:0043524negative regulation of neuron apoptotic process-IEAProcess
GO:0043537negative regulation of blood vessel endothelial cell migration23960241.IDAProcess
GO:0045892negative regulation of transcription, DNA-templated11441023.IDAProcess
GO:0045893positive regulation of transcription, DNA-templated-IEAProcess
GO:0046470phosphatidylcholine metabolic process-IEAProcess
GO:0047485protein N-terminus binding11441023.IPIFunction
GO:0050432catecholamine secretion-IEAProcess
GO:0051151negative regulation of smooth muscle cell differentiation-IEAProcess
GO:0051965positive regulation of synapse assembly-IEAProcess
GO:0060079excitatory postsynaptic potential-IEAProcess
GO:0060291long-term synaptic potentiation-IEAProcess
GO:0090063positive regulation of microtubule nucleation25527496.IMPProcess
GO:0098794postsynapse-IEAComponent
GO:1900114positive regulation of histone H3-K9 trimethylation-IEAProcess
GO:1905643positive regulation of DNA methylation23960241.IDAProcess
GO:2000820negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation-IEAProcess
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us