EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25227661	Epigenetic silencing of methyl-CpG-binding protein 2 gene affects proliferation, invasion, migration, and apoptosis of human osteosarcoma cells.	Tumour Biol	2014 Dec	Meng G	doi: 10.1007/s13277-014-2336-8
12646234	Methyl-CpG-DNA binding proteins in human prostate cancer: expression of CXXC sequence containing MBD1 and repression of MBD2 and MeCP2.	Biochem Biophys Res Commun	2003 Mar 21	Patra SK	-
25827305	Prognostic values of 5-hmC, 5-mC and TET2 in epithelial ovarian cancer.	Arch Gynecol Obstet	2015 Oct	Zhang LY	doi: 10.1007/s00404-015-3704-3
27377594	Rb silencing mediated by the down-regulation of MeCP2 is involved in cell transformation induced by long-term exposure to hydroquinone.	Mol Carcinog	2017 Feb	Liu L	doi: 10.1002/mc.22523
24531693	Chromatin composition alterations and the critical role of MeCP2 for epigenetic silencing of progesterone receptor-B gene in endometrial cancers.	Cell Mol Life Sci	2014 Sep	Chu Y	doi: 10.1007/s00018-014-1580-9
16331274	The methyl-CpG-binding protein MECP2 is required for prostate cancer cell growth.	Oncogene	2006 Mar 2	Bernard D	-
26648260	Lentivirusmediated knockdown of MeCP2 inhibits the growth of colorectal cancer cells in vitro.	Mol Med Rep	2016 Jan	Song N	doi: 10.3892/mmr.2015.4612
23135915	Epigenetic regulation by Z-DNA silencer function controls cancer-associated ADAM-12 expression in breast cancer: cross-talk between MeCP2 and NF1 transcription factor family.	Cancer Res	2013 Jan 15	Ray BK	doi: 10.1158/0008-5472.CAN-12-2601
18666890	Silencing of MBD1 and MeCP2 in prostate-cancer-derived PC3 cells produces differential gene expression profiles and cellular phenotypes.	Biosci Rep	2008 Dec	Yaqinuddin A	doi: 10.1042/BSR20080032.
25705847	Genome-Wide DNA Methylation Analysis in Melanoma Reveals the Importance of CpG Methylation in MITF Regulation.	J Invest Dermatol	2015 Jul	Lauss M	doi: 10.1038/jid.2015.61
28131747	MeCP2 Promotes Gastric Cancer Progression Through Regulating FOXF1/Wnt5a/β-Catenin and MYOD1/Caspase-3 Signaling Pathways.	EBioMedicine	2017 Feb	Zhao L	doi: 10.1016/j.ebiom.2017.01.021
28767600	MECP2 expression in gastric cancer and its correlation with clinical pathological parameters.	Medicine (Baltimore)	2017 Aug	Zhang J	doi: 10.1097/MD.0000000000007691.
28329686	Demethylated HSATII DNA and HSATII RNA Foci Sequester PRC1 and MeCP2 into Cancer-Specific Nuclear Bodies.	Cell Rep	2017 Mar 21	Hall LL	doi: 10.1016/j.celrep.2017.02.072.
28100567	MeCP2 regulated glycogenes contribute to proliferation and apoptosis of gastric cancer cells.	Glycobiology	2017 Apr 1	Qin Y	doi: 10.1093/glycob/cwx006.
26910839	MeCP2 suppresses LIN28A expression via binding to its methylated-CpG islands in pancreatic cancer cells.	Oncotarget	2016 Mar 22	Xu M	doi: 10.18632/oncotarget.7507.
27166996	MECP2 promotes the growth of gastric cancer cells by suppressing miR-338-mediated antiproliferative effect.	Oncotarget	2016 Jun 7	Tong D	doi: 10.18632/oncotarget.9197.
29869456	CpG Island Methylator Phenotype and Methylation of Wnt Pathway Genes Together Predict Survival in Patients with Colorectal Cancer.	Yonsei Med J	2018 Jul	Kim SH	doi: 10.3349/ymj.2018.59.5.588.
29568890	miR-19a/b and MeCP2 repress reciprocally to regulate multidrug resistance in gastric cancer cells.	Int J Mol Med	2018 Jul	Zhu F	doi: 10.3892/ijmm.2018.3581
28291253	Mecp2-mediated Epigenetic Silencing of miR-137 Contributes to Colorectal Adenoma-Carcinoma Sequence and Tumor Progression via Relieving the Suppression of c-Met.	Sci Rep	2017 Mar 14	Chen T	doi: 10.1038/srep44543.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chrX	154030464	Frame_Shift_Ins	novel	*E455Gfs32**	0.08
ACC	chrX	154030423	Missense_Mutation	novel	P469S	0.24
BLCA	chrX	154030511	Silent	novel	A439A	0.93
BLCA	chrX	154032280	Missense_Mutation	novel	E102K	0.72
BLCA	chrX	154031019	Missense_Mutation	novel	R270Q	0.96
BLCA	chrX	154031125	Missense_Mutation	novel	E235K	0.3
BRCA	chrX	154030934	Missense_Mutation	NA	E298D	0.4
BRCA	chrX	154030061	3'UTR	novel		0.17
BRCA	chrX	154032331	Missense_Mutation	NA	R85C	0.31
BRCA	chrX	154030487	In_Frame_Ins	novel	T442_A447dup	0.1
BRCA	chrX	154028462	3'UTR	novel		0.18
BRCA	chrX	154030155	3'UTR	novel		0.52
BRCA	chrX	154023995	3'UTR	novel		0.24
BRCA	chrX	154031354	Silent	rs61748413	T158T	0.25
BRCA	chrX	154030289	3'UTR	novel		0.19
BRCA	chrX	154030501	Missense_Mutation	novel	A443P	0.2
BRCA	chrX	154029951	3'UTR	rs141497603		0.14
BRCA	chrX	154030903	Missense_Mutation	rs61751444	R309W	0.16
BRCA	chrX	154031390	Silent	rs61748386	G146G	0.37
BRCA	chrX	154031430	Missense_Mutation	rs61748389	R133H	0.24	MBD
CESC	chrX	154030749	Missense_Mutation	NA	S360L	0.31
CESC	chrX	154031162	Silent	rs61749735	V222V	0.22
CESC	chrX	154023254	3'UTR	novel		0.37
CESC	chrX	154030844	Silent	rs61751442	L328L	0.18
CESC	chrX	154023453	3'UTR	novel		0.09
CESC	chrX	154024823	3'UTR	novel		0.2
CESC	chrX	154030791	In_Frame_Del	novel	S346_K347del	0.09
CESC	chrX	154026821	3'UTR	novel		0.47
CESC	chrX	154023559	3'UTR	novel		0.28
CESC	chrX	154024739	3'UTR	novel		0.39
CESC	chrX	154025681	3'UTR	novel		0.48
CESC	chrX	154028373	3'UTR	novel		0.56
CESC	chrX	154030020	3'UTR	novel		0.38
CESC	chrX	154030499	Silent	rs782706777	A443A	0.45
CESC	chrX	154031223	Missense_Mutation	rs587783138	A202V	0.34
CESC	chrX	154032267	Missense_Mutation	rs61754457	R106Q	0.39
CESC	chrX	154026867	3'UTR	novel		0.26
CESC	chrX	154029603	3'UTR	novel		0.33
CESC	chrX	154030117	3'UTR	novel		0.52
COAD	chrX	154030534	Frame_Shift_Del	novel	*E432Afs3**	0.03
COAD	chrX	154030917	Missense_Mutation	rs267608550	K304R	0.19
COAD	chrX	154031402	Silent	rs61748397	F142F	0.19
COAD	chrX	154030343	3'UTR	novel		0.28
COAD	chrX	154030826	Silent	novel	K334K	0.27
COAD	chrX	154030994	Silent	rs61750248	A278A	0.55
COAD	chrX	154030768	Missense_Mutation	rs143876280	R354C	0.58
COAD	chrX	154030512	Missense_Mutation	rs782805738	A439V	0.36
COAD	chrX	154031443	Missense_Mutation	novel	G129R	0.12	MBD
COAD	chrX	154031409	Missense_Mutation	rs28934908	A140V	0.21	MBD
COAD	chrX	154030381	Missense_Mutation	novel	E483K	0.73
COAD	chrX	154030533	Nonsense_Mutation	novel	*E432Vfs2**	0.05
COAD	chrX	154030482	Frame_Shift_Del	NA	*K449Sfs33**	0.2
ESCA	chrX	154024007	3'UTR	novel		0.19
ESCA	chrX	154024726	3'UTR	novel		0.27
ESCA	chrX	154030281	3'UTR	rs782213317		0.24
ESCA	chrX	154030411	Missense_Mutation	rs782115829	E473Q	0.21
ESCA	chrX	154030382	Silent	rs76895094	T482T	0.35
ESCA	chrX	154023965	3'UTR	novel		0.67
ESCA	chrX	154021889	3'UTR	novel		0.26
ESCA	chrX	154031120	Silent	novel	G236G	0.2
ESCA	chrX	154021864	3'UTR	novel		0.44
ESCA	chrX	154022105	3'UTR	rs782502891		0.8
ESCA	chrX	154025908	3'UTR	novel		0.38
ESCA	chrX	154029952	3'UTR	novel		0.82
ESCA	chrX	154029141	3'UTR	novel		0.35
GBM	chrX	154032318	Missense_Mutation	novel	R89H	0.36
GBM	chrX	154030418	Missense_Mutation	NA	N470K	0.26
GBM	chrX	154032441	Missense_Mutation	novel	P48Q	0.19
GBM	chrX	154031261	Silent	novel	G189G	0.67
GBM	chrX	154030313	3'UTR	novel		0.17
GBM	chrX	154030276	3'UTR	novel		0.17
HNSC	chrX	154031219	Silent	rs61749722	T203T	0.42
HNSC	chrX	154031357	Silent	novel	F157F	0.83
KICH	chrX	154030987	Missense_Mutation	rs782239416	A281T	0.9
KIRC	chrX	154031435	Silent	rs61748385	A131A	0.16
KIRC	chrX	154032366	Missense_Mutation	NA	A73V	0.08
KIRP	chrX	154092261	5'UTR	novel		0.84
LAML	chrX	154032532	Frame_Shift_Ins	novel	*L18Ffs13**	0.44
LGG	chrX	154032323	Silent	NA	I87I	0.83
LIHC	chrX	154031355	Missense_Mutation	rs28934906	T158M	0.86
LIHC	chrX	154030432	Missense_Mutation	NA	M466L	0.41
LUAD	chrX	154031010	Missense_Mutation	NA	G273V	0.3
LUAD	chrX	154032435	Missense_Mutation	novel	A50G	0.09
LUAD	chrX	154032486	Missense_Mutation	novel	K33T	0.05
LUAD	chrX	154032375	Missense_Mutation	novel	S70Y	0.52
LUAD	chrX	154032358	Missense_Mutation	novel	E76K	0.22
LUAD	chrX	154030987	Missense_Mutation	novel	A281S	0.17
LUAD	chrX	154030919	Missense_Mutation	rs61751439	I303M	0.2
LUAD	chrX	154030803	Missense_Mutation	NA	P342L	0.16
LUAD	chrX	154092300	5'UTR	novel		0.15
LUAD	chrX	154097636	5'UTR	novel		0.44
LUAD	chrX	154097637	5'UTR	novel		0.46
LUAD	chrX	154032379	Missense_Mutation	novel	G69C	0.22
LUAD	chrX	154031002	Missense_Mutation	novel	V276L	0.36
LUAD	chrX	154032495	Missense_Mutation	novel	K30T	0.08
LUSC	chrX	154030919	Missense_Mutation	rs61751439	I303M	0.28
LUSC	chrX	154030848	Missense_Mutation	NA	T327N	0.36
LUSC	chrX	154032225	Missense_Mutation	NA	Y120C	0.3	MBD
LUSC	chrX	154031064	Missense_Mutation	novel	R255Q	0.24
LUSC	chrX	154092266	5'UTR	novel		0.2
OV	chrX	154032342	In_Frame_Del	novel	A73_P81del	0.31
OV	chrX	154030631	Silent	novel	P399P	0.64
OV	chrX	154030608	Frame_Shift_Del	novel	*D407Afs2**	0.1
OV	chrX	154032244	Missense_Mutation	novel	G114R	0.28	MBD
OV	chrX	154030271	3'UTR	novel		0.05
OV	chrX	154031032	In_Frame_Ins	novel	P265_K266insD	0.05
PAAD	chrX	154030314	3'UTR	novel		0.07
PAAD	chrX	154030848	Missense_Mutation	novel	T327I	0.03
PCPG	chrX	154031280	Missense_Mutation	novel	G183E	0.18
PRAD	chrX	154032531	Missense_Mutation	novel	L18P	0.81
READ	chrX	154031355	Missense_Mutation	rs28934906	T158M	0.55
SARC	chrX	154030151	3'UTR	novel		0.33
SARC	chrX	154026880	3'UTR	novel		0.33
SARC	chrX	154023874	3'UTR	novel		1
SKCM	chrX	154031179	Missense_Mutation	rs786205894	P217S	0.36
SKCM	chrX	154030678	Missense_Mutation	rs373116070	P384S	0.18
SKCM	chrX	154030863	Missense_Mutation	rs61751450	P322L	0.62
SKCM	chrX	154031402	Silent	rs61748397	F142F	0.21
SKCM	chrX	154030177	3'UTR	novel		0.18
SKCM	chrX	154031040	Missense_Mutation	rs782576004	A263V	0.4
SKCM	chrX	154031255	Silent	rs61749710	P191P	0.98
SKCM	chrX	154031256	Missense_Mutation	novel	P191L	0.98
SKCM	chrX	154030625	Silent	rs782230851	S401S	0.72
SKCM	chrX	154030744	Missense_Mutation	NA	P362S	0.41
STAD	chrX	154031302	Missense_Mutation	rs186663314	P176S	0.48
STAD	chrX	154032352	Missense_Mutation	novel	S78A	0.26
STAD	chrX	154030640	Silent	rs781816931	S396S	0.81
STAD	chrX	154030455	Missense_Mutation	rs185957513	R458H	0.21
STAD	chrX	154032549	Missense_Mutation	NA	K12R	0.11
STAD	chrX	154097643	5'UTR	novel		0.5
STAD	chrX	154032529	Missense_Mutation	NA	Q19E	0.22
STAD	chrX	154030455	Missense_Mutation	rs185957513	R458H	0.14
STAD	chrX	154032268	Missense_Mutation	rs28934907	R106W	0.44
STAD	chrX	154030256	3'UTR	novel		0.25
STAD	chrX	154030245	3'UTR	rs267608342		0.77
STAD	chrX	154030372	Missense_Mutation	NA	S486R	0.73
STAD	chrX	154030606	Silent	NA	L408L	0.09
STAD	chrX	154031117	Frame_Shift_Ins	rs267608517	*G238Wfs21**	0.18
THCA	chrX	154031449	Missense_Mutation	NA	P127S	0.09	MBD
THYM	chrX	154031377	Missense_Mutation	novel	D151N	0.17	MBD
THYM	chrX	154032246	Missense_Mutation	rs781871640	S113F	0.58	MBD
THYM	chrX	154021864	3'UTR	novel		0.08
UCEC	chrX	154023213	3'UTR	novel		0.1
UCEC	chrX	154032334	Missense_Mutation	NA	R84W	0.34
UCEC	chrX	154030958	Silent	rs587781032	E290E	0.35
UCEC	chrX	154023715	3'UTR	novel		0.36
UCEC	chrX	154028281	3'UTR	novel		0.1
UCEC	chrX	154025093	3'UTR	novel		0.15
UCEC	chrX	154031156	Missense_Mutation	novel	M224I	0.34
UCEC	chrX	154028420	3'UTR	novel		0.17
UCEC	chrX	154030023	3'UTR	novel		0.25
UCEC	chrX	154023100	3'UTR	novel		0.14
UCEC	chrX	154024097	3'UTR	novel		0.3
UCEC	chrX	154030164	3'UTR	novel		0.27
UCEC	chrX	154030610	Missense_Mutation	novel	Q406H	0.29
UCEC	chrX	154025756	3'UTR	novel		0.26
UCEC	chrX	154030832	Silent	rs148744894	S332S	0.14
UCEC	chrX	154024201	3'UTR	novel		0.27
UCEC	chrX	154030142	3'UTR	novel		0.29
UCEC	chrX	154030912	Missense_Mutation	rs28935468	R306C	0.34
UCEC	chrX	154032246	Missense_Mutation	novel	S113Y	0.41	MBD
UCEC	chrX	154024879	3'UTR	rs202139104		0.22
UCEC	chrX	154030275	3'UTR	rs62621672		0.35
UCEC	chrX	154031288	Silent	novel	K180K	0.12
UCEC	chrX	154026382	3'UTR	novel		0.35
UCEC	chrX	154030039	3'UTR	rs62621673		0.36
UCEC	chrX	154024853	3'UTR	novel		0.18
UCEC	chrX	154028297	3'UTR	novel		0.23
UCEC	chrX	154030245	3'UTR	novel		0.12
UCEC	chrX	154031401	Missense_Mutation	NA	E143K	0.22	MBD
UCEC	chrX	154021864	3'UTR	novel		0.36
UCEC	chrX	154024735	3'UTR	rs781867993		0.39
UCEC	chrX	154030397	Silent	NA	S477S	0.14
UCEC	chrX	154030547	Silent	rs374900442	D427D	0.29
UCEC	chrX	154024924	3'UTR	rs782188234		0.44
UCEC	chrX	154030846	Missense_Mutation	novel	L328I	0.21
UCEC	chrX	154031326	Nonsense_Mutation	rs61748421	R168*	0.15
UCEC	chrX	154030001	3'UTR	novel		0.13
UCEC	chrX	154023036	3'UTR	novel		0.57
UCEC	chrX	154030254	3'UTR	novel		0.58
UCEC	chrX	154024096	3'UTR	rs781989800		0.27
UCEC	chrX	154024595	3'UTR	novel		0.57
UCEC	chrX	154026017	3'UTR	novel		0.4
UCEC	chrX	154028092	3'UTR	novel		0.39
UCEC	chrX	154021995	3'UTR	novel		0.09
UCEC	chrX	154026783	3'UTR	novel		0.13
UCEC	chrX	154023206	3'UTR	novel		0.3
UCEC	chrX	154029131	3'UTR	novel		0.3
UCEC	chrX	154030250	3'UTR	novel		0.18
UCEC	chrX	154032470	Silent	novel	E38E	0.21
UCEC	chrX	154025086	3'UTR	novel		0.26
UCEC	chrX	154027127	3'UTR	novel		0.26
UCEC	chrX	154032287	Silent	novel	T99T	0.28
UCEC	chrX	154026880	3'UTR	rs782160189		0.22
UCEC	chrX	154021864	3'UTR	novel		0.47
UCEC	chrX	154024726	3'UTR	novel		0.19
UCEC	chrX	154023016	3'UTR	novel		0.39
UCEC	chrX	154024256	3'UTR	novel		0.23
UCEC	chrX	154026775	3'UTR	novel		0.3
UCEC	chrX	154026894	3'UTR	novel		0.38
UCEC	chrX	154028245	3'UTR	novel		0.23
UCEC	chrX	154030244	3'UTR	rs782225490		0.64
UCEC	chrX	154026776	3'UTR	novel		0.3
UCEC	chrX	154023945	3'UTR	novel		0.19
UCEC	chrX	154021961	3'UTR	novel		0.42
UCEC	chrX	154024659	3'UTR	novel		0.42
UCEC	chrX	154026403	3'UTR	novel		0.36
UCEC	chrX	154030574	Missense_Mutation	NA	M418I	0.46
UCEC	chrX	154031401	Missense_Mutation	NA	E143K	0.18	MBD
UCEC	chrX	154030224	3'UTR	novel		0.44
UCEC	chrX	154030911	Missense_Mutation	rs61751443	R306H	0.36
UCEC	chrX	154029926	3'UTR	novel		0.19
UCEC	chrX	154029622	3'UTR	novel		0.6
UCEC	chrX	154030223	3'UTR	novel		0.5
UCEC	chrX	154030739	Missense_Mutation	novel	K363N	0.55
UCEC	chrX	154021814	3'UTR	novel		0.43
UCEC	chrX	154021864	3'UTR	novel		0.6
UCEC	chrX	154024726	3'UTR	novel		0.41
UCEC	chrX	154021864	3'UTR	novel		0.17
UCEC	chrX	154021999	3'UTR	novel		0.36
UCEC	chrX	154024948	3'UTR	novel		0.16
UCEC	chrX	154025913	3'UTR	novel		0.28
UCEC	chrX	154027946	3'UTR	novel		0.29
UCEC	chrX	154028299	3'UTR	novel		0.44
UCEC	chrX	154029105	3'UTR	novel		0.3
UCEC	chrX	154030381	Missense_Mutation	novel	E483K	0.39
UCEC	chrX	154021864	3'UTR	novel		0.18
UCEC	chrX	154024726	3'UTR	novel		0.27
UCEC	chrX	154025901	3'UTR	novel		0.27
UCEC	chrX	154026445	3'UTR	novel		0.35
UCEC	chrX	154028437	3'UTR	novel		0.3
UCEC	chrX	154030989	Missense_Mutation	novel	A280V	0.09
UCEC	chrX	154031204	Missense_Mutation	novel	Q208H	0.38
UCEC	chrX	154024726	3'UTR	novel		0.36
UCEC	chrX	154029974	3'UTR	rs267608361		0.2
UCEC	chrX	154030232	3'UTR	novel		0.24
UCEC	chrX	154030501	Missense_Mutation	rs193922677	A443T	0.44
UCEC	chrX	154031065	Nonsense_Mutation	rs61749721	R255*	0.44
UCEC	chrX	154032502	Missense_Mutation	novel	F28L	0.13
UCEC	chrX	154025846	3'UTR	novel		0.42
UCEC	chrX	154030993	Missense_Mutation	rs371234586	A279T	0.33
UCEC	chrX	154031402	Silent	rs61748397	F142F	0.39
UCEC	chrX	154028052	3'UTR	novel		0.28
UCEC	chrX	154029573	3'UTR	novel		0.32
UCEC	chrX	154032488	Missense_Mutation	novel	K32N	0.39
UCEC	chrX	154024726	3'UTR	novel		0.3
UCEC	chrX	154024823	3'UTR	novel		0.46
UCEC	chrX	154031065	Nonsense_Mutation	rs61749721	R255*	0.61
UCEC	chrX	154023260	3'UTR	novel		0.32
UCEC	chrX	154023400	3'UTR	novel		0.38
UCEC	chrX	154024046	3'UTR	novel		0.31
UCEC	chrX	154026622	3'UTR	novel		0.45
UCEC	chrX	154026775	3'UTR	novel		0.42
UCEC	chrX	154027127	3'UTR	novel		0.47
UCEC	chrX	154028068	3'UTR	novel		0.27
UCEC	chrX	154029249	3'UTR	rs186774570		0.39
UCEC	chrX	154031408	Silent	rs782082759	A140A	0.5
UCEC	chrX	154023845	3'UTR	novel		0.3
UCEC	chrX	154031402	Silent	rs61748397	F142F	0.56
UCEC	chrX	154031133	Frame_Shift_Del	rs63260260	*G232Afs16**	0.47
UCEC	chrX	154030223	3'UTR	novel		0.15
UCEC	chrX	154024872	3'UTR	novel		0.17
UCEC	chrX	154030863	Missense_Mutation	rs61751450	P322L	0.35
UCEC	chrX	154030511	Silent	rs146632223	A439A	0.32
UCEC	chrX	154024725	3'UTR	novel		0.49
UCEC	chrX	154024726	3'UTR	novel		0.41
UCEC	chrX	154026007	3'UTR	novel		0.31
UCEC	chrX	154029248	3'UTR	novel		0.44
UCEC	chrX	154029946	3'UTR	novel		0.32
UCEC	chrX	154032557	Missense_Mutation	NA	R9S	0.16
UCEC	chrX	154092191	Missense_Mutation	novel	G7W	0.12
UCEC	chrX	154031073	Missense_Mutation	NA	G252D	0.31
UCEC	chrX	154024735	3'UTR	rs781867993		0.4
UCEC	chrX	154030307	3'UTR	novel		0.37
UCEC	chrX	154032331	Missense_Mutation	NA	R85C	0.19
UCEC	chrX	154026336	3'UTR	novel		0.57
UCEC	chrX	154092212	5'UTR	novel		0.24
UCEC	chrX	154024017	3'UTR	novel		0.33
UCEC	chrX	154030307	3'UTR	novel		0.31
UCEC	chrX	154025950	3'UTR	novel		0.52
UCEC	chrX	154029446	3'UTR	novel		0.31
UCEC	chrX	154024069	3'UTR	novel		0.31
UCEC	chrX	154024726	3'UTR	novel		0.13
UCEC	chrX	154029955	3'UTR	novel		0.38
UCEC	chrX	154030505	Silent	rs781964746	A441A	0.32
UCEC	chrX	154026365	3'UTR	novel		0.36
UCEC	chrX	154030814	Silent	NA	T338T	0.28
UCEC	chrX	154024590	3'UTR	novel		0.16
UCEC	chrX	154021995	3'UTR	novel		0.25
UCEC	chrX	154023504	3'UTR	novel		0.36
UCEC	chrX	154026427	3'UTR	novel		0.33
UCEC	chrX	154031390	Silent	rs61748386	G146G	0.41
UCEC	chrX	154024735	3'UTR	rs781867993		0.26
UCEC	chrX	154028207	3'UTR	novel		0.35
UCEC	chrX	154030501	Missense_Mutation	rs193922677	A443T	0.33
UCS	chrX	154030354	3'UTR	rs782334844		0.41

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	AMP	0.1932	3.2002e-05
DLBC	AMP	0.1458	0.24013
ESCA	AMP	0.2717	0.18371
HNSC	AMP	0.2107	0.0095371
KIRC	AMP	0.0436	0.12739
LIHC	AMP	0.1541	0.011319
LUSC	AMP	0.1776	0.08275
OV	AMP	0.3143	2.176e-06
PAAD	AMP	0.0761	0.041079
READ	AMP	0.1515	0.14805
STAD	AMP	0.1111	0.0021069
TGCT	DEL	0.0667	0.08422
THCA	DEL	0.002	0.21991
UCEC	AMP	0.0928	0.010288
UCS	DEL	0.2857	0.063955

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
SARC	0.012	Kaplan-Meier Survival Analysis
MESO	0.018	Kaplan-Meier Survival Analysis
BRCA	0.014	Kaplan-Meier Survival Analysis
COAD	0.032	Kaplan-Meier Survival Analysis
PAAD	0.0018	Kaplan-Meier Survival Analysis
PCPG	0.038	Kaplan-Meier Survival Analysis
CESC	0.001	Kaplan-Meier Survival Analysis
UCEC	0.00071	Kaplan-Meier Survival Analysis
LUAD	0.003	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000169057 (Gene tree)
Gene ID: 4204
Gene Symbol: MECP2
Alias: RTT|MRX16|MRX79
Full Name: methyl-CpG binding protein 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 115,531 bases
Position: chrX:154,021,573-154,137,103
Accession: 6990
RBP type: canonical RBP
Summary: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of cognitive disability in females. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000479736	MBD	PF01429.19	4.9e-17	1	1
ENSP00000492871	MBD	PF01429.19	1.2e-16	1	1
ENSP00000484470	MBD	PF01429.19	1.6e-16	1	1
ENSP00000301948	MBD	PF01429.19	2.7e-16	1	1
ENSP00000395535	MBD	PF01429.19	2.8e-16	1	1
ENSP00000486978	MBD	PF01429.19	6.5e-14	1	1
ENSP00000384865	MBD	PF01429.19	7.4e-14	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
17028371	The molecular pathology of Rett syndrome: synopsis and update.	Neuromolecular Med	2006	Akbarian S	-
16251272	Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2.	Proc Natl Acad Sci U S A	2005 Dec 6	Young JI	-
27732849	MECP2 Is Post-transcriptionally Regulated during Human Neurodevelopment by Combinatorial Action of RNA-Binding Proteins and miRNAs.	Cell Rep	2016 Oct 11	Rodrigues DC	doi: 10.1016/j.celrep.2016.09.049.
30136864	Gordon H. Dixon's trace in my personal career and the quantic jump experienced in regulatory information.	Syst Biol Reprod Med	2018 Dec	Mezquita-Pla J	doi: 10.1080/19396368.2018.1503752
18666890	Silencing of MBD1 and MeCP2 in prostate-cancer-derived PC3 cells produces differential gene expression profiles and cellular phenotypes.	Biosci Rep	2008 Dec	Yaqinuddin A	doi: 10.1042/BSR20080032.
25837375	The alternative role of DNA methylation in splicing regulation.	Trends Genet	2015 May	Lev Maor G	doi: 10.1016/j.tig.2015.03.002
28480880	Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment.	Nat Commun	2017 May 8	Wong JJ	doi: 10.1038/ncomms15134.
19812320	Synaptic circuit abnormalities of motor-frontal layer 2/3 pyramidal neurons in an RNA interference model of methyl-CpG-binding protein 2 deficiency.	J Neurosci	2009 Oct 7	Wood L	doi: 10.1523/JNEUROSCI.3321-09.2009.
17988628	The story of Rett syndrome: from clinic to neurobiology.	Neuron	2007 Nov 8	Chahrour M	-
28352654	NET silencing by let-7i in postural tachycardia syndrome.	JCI Insight	2017 Mar 23	Khan AW	doi: 10.1172/jci.insight.90183.
25444166	Brain-derived neurotrophic factor epigenetic modifications associated with schizophrenia-like phenotype induced by prenatal stress in mice.	Biol Psychiatry	2015 Mar 15	Dong E	doi: 10.1016/j.biopsych.2014.08.012
28416772	DNA methylation of METTL7A gene body regulates its transcriptional level in thyroid cancer.	Oncotarget	2017 May 23	Zhou S	doi: 10.18632/oncotarget.16147.
29282321	A mixed modality approach towards Xi reactivation for Rett syndrome and other X-linked disorders.	Proc Natl Acad Sci U S A	2018 Jan 23	Carrette LLG	doi: 10.1073/pnas.1715124115
29409936	Epigenetic regulation by CpG methylation splits strong from retarded IFNγ-induced IL-18BP in epithelial versus monocytic cells.	Biochim Biophys Acta Gene Regul Mech	2018 Mar	Bachmann M	doi: 10.1016/j.bbagrm.2018.01.020
30008886	DNA methylation contributes to silencing the expression of linc00086 in gastric cancer.	Oncol Lett	2018 Aug	Yang Y	doi: 10.3892/ol.2018.8868
16052033	Specific binding of the methyl binding domain protein 2 at the BRCA1-NBR2 locus.	Nucleic Acids Res	2005 Jul 28	Auriol E	-
17133344	Multiple binding of methyl-CpG and polycomb proteins in long-term gene silencing events.	J Cell Physiol	2007 Mar	Matarazzo MR	-
27965390	DNA methylation in the gene body influences MeCP2-mediated gene repression.	Proc Natl Acad Sci U S A	2016 Dec 27	Kinde B	doi: 10.1073/pnas.1618737114
28523538	MeCP2, A Modulator of Neuronal Chromatin Organization Involved in Rett Syndrome.	Adv Exp Med Biol	2017	Martinez de Paz A	doi: 10.1007/978-3-319-53889-1_1.
29019980	Radically truncated MeCP2 rescues Rett syndrome-like neurological defects.	Nature	2017 Oct 19	Tillotson R	doi: 10.1038/nature24058

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000622433	MECP2-213	1071	-	ENSP00000484470	324 (aa)	-	A0A087X1U4
ENST00000637917	MECP2-224	159	-	ENSP00000489847	53 (aa)	-	A0A1B0GTV0
ENST00000631210	MECP2-220	490	-	-	- (aa)	-	-
ENST00000626422	MECP2-215	835	-	-	- (aa)	-	-
ENST00000453960	MECP2-205	1729	-	ENSP00000395535	498 (aa)	-	P51608
ENST00000630151	MECP2-219	322	-	ENSP00000486089	41 (aa)	-	A0A0D9SEX1
ENST00000460227	MECP2-206	1298	-	-	- (aa)	-	-
ENST00000415944	MECP2-204	413	-	ENSP00000416267	49 (aa)	-	C9JH89
ENST00000637467	MECP2-221	101	-	-	- (aa)	-	-
ENST00000611468	MECP2-212	603	-	ENSP00000479736	168 (aa)	-	A0A087WVW7
ENST00000628176	MECP2-217	1712	-	ENSP00000486978	172 (aa)	-	A0A0D9SFX7
ENST00000303391	MECP2-201	10505	XM_006724819	ENSP00000301948	486 (aa)	XP_006724882	P51608
ENST00000407218	MECP2-203	1174	-	ENSP00000384865	184 (aa)	-	B5MCB4
ENST00000627864	MECP2-216	581	-	-	- (aa)	-	-
ENST00000369957	MECP2-202	784	-	ENSP00000358973	37 (aa)	-	H7BY72
ENST00000637533	MECP2-222	140	-	-	- (aa)	-	-
ENST00000488293	MECP2-210	1198	-	-	- (aa)	-	-
ENST00000637791	MECP2-223	101	-	-	- (aa)	-	-
ENST00000481807	MECP2-208	436	-	-	- (aa)	-	-
ENST00000625300	MECP2-214	350	-	-	- (aa)	-	-
ENST00000463644	MECP2-207	1088	-	-	- (aa)	-	-
ENST00000486506	MECP2-209	2907	-	-	- (aa)	-	-
ENST00000638041	MECP2-225	100	-	-	- (aa)	-	-
ENST00000640414	MECP2-226	897	-	ENSP00000492871	271 (aa)	-	I6LM39
ENST00000629277	MECP2-218	2558	-	-	- (aa)	-	-
ENST00000496908	MECP2-211	342	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000169057's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000169057	Child Development Disorders, Pervasive	4.8814100E-005	-
ENSG00000169057	Child Development Disorders, Pervasive	5.9476100E-005	-
ENSG00000169057	Child Development Disorders, Pervasive	4.8814100E-005	-
ENSG00000169057	Child Development Disorders, Pervasive	4.6750400E-006	-
ENSG00000169057	Child Development Disorders, Pervasive	2.5642600E-005	-
ENSG00000169057	Child Development Disorders, Pervasive	3.4092400E-006	-
ENSG00000169057	Child Development Disorders, Pervasive	2.8884900E-006	-
ENSG00000169057	Child Development Disorders, Pervasive	1.0967600E-006	-
ENSG00000169057	Child Development Disorders, Pervasive	1.0401500E-005	-
ENSG00000169057	Child Development Disorders, Pervasive	4.7229200E-006	-
ENSG00000169057	Child Development Disorders, Pervasive	4.6750400E-006	-
ENSG00000169057	Child Development Disorders, Pervasive	2.5642600E-005	-
ENSG00000169057	Child Development Disorders, Pervasive	3.4092400E-006	-
ENSG00000169057	Child Development Disorders, Pervasive	2.8884900E-006	-
ENSG00000169057	Child Development Disorders, Pervasive	1.0967600E-006	-
ENSG00000169057	Child Development Disorders, Pervasive	1.0401500E-005	-
ENSG00000169057	Child Development Disorders, Pervasive	4.7229200E-006	-
ENSG00000169057	Child Development Disorders, Pervasive	3.3854300E-005	-
ENSG00000169057	Child Development Disorders, Pervasive	2.9114700E-005	-
ENSG00000169057	Child Development Disorders, Pervasive	1.3535900E-005	-
ENSG00000169057	Child Development Disorders, Pervasive	3.5188000E-005	-
ENSG00000169057	Child Development Disorders, Pervasive	3.3854300E-005	-
ENSG00000169057	Child Development Disorders, Pervasive	2.9114700E-005	-
ENSG00000169057	Child Development Disorders, Pervasive	1.3535900E-005	-
ENSG00000169057	Child Development Disorders, Pervasive	3.5188000E-005	-
ENSG00000169057	Lupus Erythematosus, Systemic	2E-15	26502338
ENSG00000169057	Arthritis, Rheumatoid	5E-16	24390342
ENSG00000169057	Arthritis, Rheumatoid	3E-12	24390342

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000169057	rs5987194	X	154036016	C	Rheumatoid arthritis	24390342	[1.12-1.20]	1.16	EFO_0000685
ENSG00000169057	rs5987194	X	154036016	C	Rheumatoid arthritis	24390342	[1.12-1.21]	1.16	EFO_0000685
ENSG00000169057	rs3027933	X	154033423	?	Non-albumin protein levels	29403010	[0.017-0.034] unit decrease novel	0.02511	EFO_0004568

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000169057's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000169057	MECP2	93	62.805	ENSAPOG00000002652	mecp2	71	52.660	Acanthochromis_polyacanthus
ENSG00000169057	MECP2	98	100.000	ENSAMEG00000018448	MECP2	99	92.577	Ailuropoda_melanoleuca
ENSG00000169057	MECP2	54	84.615	ENSAPEG00000023997	mecp2	51	58.661	Amphiprion_percula
ENSG00000169057	MECP2	54	76.027	ENSATEG00000019486	mecp2	55	58.586	Anabas_testudineus
ENSG00000169057	MECP2	91	85.621	ENSACAG00000012519	MECP2	90	68.432	Anolis_carolinensis
ENSG00000169057	MECP2	100	98.837	ENSANAG00000019603	MECP2	100	98.837	Aotus_nancymaae
ENSG00000169057	MECP2	77	66.197	ENSAMXG00000039189	mecp2	50	56.522	Astyanax_mexicanus
ENSG00000169057	MECP2	98	100.000	ENSBTAG00000047855	MECP2	100	95.473	Bos_taurus
ENSG00000169057	MECP2	100	99.794	ENSCJAG00000016796	MECP2	100	99.794	Callithrix_jacchus
ENSG00000169057	MECP2	98	100.000	ENSCAFG00000019440	MECP2	100	96.586	Canis_familiaris
ENSG00000169057	MECP2	98	100.000	ENSCAFG00020022079	MECP2	100	96.502	Canis_lupus_dingo
ENSG00000169057	MECP2	98	100.000	ENSCHIG00000023071	MECP2	100	95.218	Capra_hircus
ENSG00000169057	MECP2	98	100.000	ENSTSYG00000007420	MECP2	100	96.708	Carlito_syrichta
ENSG00000169057	MECP2	98	100.000	ENSCAPG00000012930	MECP2	95	95.756	Cavia_aperea
ENSG00000169057	MECP2	98	100.000	ENSCPOG00000012579	MECP2	100	90.675	Cavia_porcellus
ENSG00000169057	MECP2	98	100.000	ENSCCAG00000037407	MECP2	100	97.710	Cebus_capucinus
ENSG00000169057	MECP2	100	99.799	ENSCATG00000017038	MECP2	100	99.799	Cercocebus_atys
ENSG00000169057	MECP2	98	100.000	ENSCLAG00000001648	MECP2	100	94.033	Chinchilla_lanigera
ENSG00000169057	MECP2	99	99.582	ENSCSAG00000006798	MECP2	100	99.582	Chlorocebus_sabaeus
ENSG00000169057	MECP2	98	77.108	ENSCPBG00000006868	-	64	74.699	Chrysemys_picta_bellii
ENSG00000169057	MECP2	100	99.794	ENSCANG00000028728	MECP2	100	99.794	Colobus_angolensis_palliatus
ENSG00000169057	MECP2	98	100.000	ENSCGRG00001017650	Mecp2	100	96.115	Cricetulus_griseus_chok1gshd
ENSG00000169057	MECP2	100	97.561	ENSCGRG00000005191	-	100	91.860	Cricetulus_griseus_crigri
ENSG00000169057	MECP2	99	47.177	ENSDARG00000014218	mecp2	60	60.125	Danio_rerio
ENSG00000169057	MECP2	98	100.000	ENSDNOG00000013419	MECP2	93	92.506	Dasypus_novemcinctus
ENSG00000169057	MECP2	98	100.000	ENSDORG00000014978	Mecp2	100	96.600	Dipodomys_ordii
ENSG00000169057	MECP2	97	84.144	ENSETEG00000009825	-	96	83.682	Echinops_telfairi
ENSG00000169057	MECP2	65	55.963	ENSEBUG00000007592	-	84	55.963	Eptatretus_burgeri
ENSG00000169057	MECP2	98	100.000	ENSEASG00005019188	MECP2	100	96.988	Equus_asinus_asinus
ENSG00000169057	MECP2	95	94.512	ENSECAG00000018208	MECP2	87	94.512	Equus_caballus
ENSG00000169057	MECP2	77	94.961	ENSEEUG00000003070	-	78	94.961	Erinaceus_europaeus
ENSG00000169057	MECP2	98	100.000	ENSFCAG00000011389	MECP2	100	96.586	Felis_catus
ENSG00000169057	MECP2	100	92.442	ENSFDAG00000002308	-	92	95.597	Fukomys_damarensis
ENSG00000169057	MECP2	55	43.011	ENSFHEG00000001333	-	80	42.056	Fundulus_heteroclitus
ENSG00000169057	MECP2	92	75.974	ENSGALG00000047963	MECP2	68	92.958	Gallus_gallus
ENSG00000169057	MECP2	51	87.059	ENSGACG00000000798	mecp2	56	57.358	Gasterosteus_aculeatus
ENSG00000169057	MECP2	94	81.646	ENSGAGG00000004728	MECP2	94	63.692	Gopherus_agassizii
ENSG00000169057	MECP2	100	100.000	ENSGGOG00000042467	MECP2	100	100.000	Gorilla_gorilla
ENSG00000169057	MECP2	98	59.880	ENSHBUG00000020716	-	68	70.161	Haplochromis_burtoni
ENSG00000169057	MECP2	98	100.000	ENSHGLG00000000899	MECP2	100	88.525	Heterocephalus_glaber_female
ENSG00000169057	MECP2	100	92.442	ENSHGLG00100004233	-	92	94.969	Heterocephalus_glaber_male
ENSG00000169057	MECP2	74	69.951	ENSIPUG00000013019	mecp2	50	64.130	Ictalurus_punctatus
ENSG00000169057	MECP2	100	98.765	ENSSTOG00000006094	MECP2	100	98.765	Ictidomys_tridecemlineatus
ENSG00000169057	MECP2	98	100.000	ENSJJAG00000022463	Mecp2	100	96.296	Jaculus_jaculus
ENSG00000169057	MECP2	92	90.476	ENSLACG00000011281	MECP2	90	67.411	Latimeria_chalumnae
ENSG00000169057	MECP2	94	71.779	ENSLOCG00000014725	mecp2	100	53.191	Lepisosteus_oculatus
ENSG00000169057	MECP2	98	100.000	ENSLAFG00000016292	MECP2	100	92.034	Loxodonta_africana
ENSG00000169057	MECP2	100	99.794	ENSMFAG00000033178	MECP2	100	99.794	Macaca_fascicularis
ENSG00000169057	MECP2	100	99.457	ENSMMUG00000018704	MECP2	100	99.457	Macaca_mulatta
ENSG00000169057	MECP2	100	99.799	ENSMNEG00000017455	MECP2	100	99.799	Macaca_nemestrina
ENSG00000169057	MECP2	100	99.794	ENSMLEG00000032763	MECP2	100	99.794	Mandrillus_leucophaeus
ENSG00000169057	MECP2	98	100.000	ENSMAUG00000018195	Mecp2	100	94.888	Mesocricetus_auratus
ENSG00000169057	MECP2	100	98.152	ENSMICG00000005149	MECP2	100	98.152	Microcebus_murinus
ENSG00000169057	MECP2	98	100.000	ENSMOCG00000001329	Mecp2	100	95.092	Microtus_ochrogaster
ENSG00000169057	MECP2	68	72.807	ENSMMOG00000009875	mecp2	51	84.270	Mola_mola
ENSG00000169057	MECP2	98	100.000	ENSMODG00000011643	MECP2	97	82.305	Monodelphis_domestica
ENSG00000169057	MECP2	68	64.324	ENSMALG00000014247	mecp2	53	61.455	Monopterus_albus
ENSG00000169057	MECP2	98	100.000	MGP_CAROLIEiJ_G0033170	Mecp2	100	94.856	Mus_caroli
ENSG00000169057	MECP2	98	100.000	ENSMUSG00000031393	Mecp2	100	94.444	Mus_musculus
ENSG00000169057	MECP2	98	100.000	MGP_PahariEiJ_G0031713	Mecp2	100	94.856	Mus_pahari
ENSG00000169057	MECP2	98	100.000	MGP_SPRETEiJ_G0034325	Mecp2	100	94.856	Mus_spretus
ENSG00000169057	MECP2	98	100.000	ENSMPUG00000009072	MECP2	100	93.210	Mustela_putorius_furo
ENSG00000169057	MECP2	98	100.000	ENSMLUG00000014297	MECP2	100	94.617	Myotis_lucifugus
ENSG00000169057	MECP2	98	100.000	ENSNGAG00000009171	Mecp2	100	96.393	Nannospalax_galili
ENSG00000169057	MECP2	65	74.312	ENSNBRG00000008411	mecp2	52	57.288	Neolamprologus_brichardi
ENSG00000169057	MECP2	92	100.000	ENSNLEG00000013783	-	100	100.000	Nomascus_leucogenys
ENSG00000169057	MECP2	98	100.000	ENSMEUG00000002761	MECP2	96	82.822	Notamacropus_eugenii
ENSG00000169057	MECP2	98	100.000	ENSODEG00000004523	MECP2	100	89.442	Octodon_degus
ENSG00000169057	MECP2	65	74.312	ENSONIG00000000809	mecp2	63	61.224	Oreochromis_niloticus
ENSG00000169057	MECP2	91	92.810	ENSOANG00000011024	MECP2	92	82.558	Ornithorhynchus_anatinus
ENSG00000169057	MECP2	98	100.000	ENSOCUG00000013147	MECP2	96	97.699	Oryctolagus_cuniculus
ENSG00000169057	MECP2	98	100.000	ENSOGAG00000015115	MECP2	100	97.737	Otolemur_garnettii
ENSG00000169057	MECP2	98	100.000	ENSOARG00000005806	MECP2	100	97.321	Ovis_aries
ENSG00000169057	MECP2	100	100.000	ENSPPAG00000034020	MECP2	100	100.000	Pan_paniscus
ENSG00000169057	MECP2	98	100.000	ENSPPRG00000004602	MECP2	100	96.586	Panthera_pardus
ENSG00000169057	MECP2	79	91.589	ENSPTIG00000002389	-	96	92.381	Panthera_tigris_altaica
ENSG00000169057	MECP2	98	100.000	ENSPTRG00000044429	-	98	100.000	Pan_troglodytes
ENSG00000169057	MECP2	100	100.000	ENSPTRG00000048003	MECP2	100	100.000	Pan_troglodytes
ENSG00000169057	MECP2	100	99.598	ENSPANG00000011691	MECP2	100	99.598	Papio_anubis
ENSG00000169057	MECP2	89	65.863	ENSPKIG00000023979	mecp2	62	58.610	Paramormyrops_kingsleyae
ENSG00000169057	MECP2	94	82.911	ENSPSIG00000002254	MECP2	99	78.505	Pelodiscus_sinensis
ENSG00000169057	MECP2	85	65.517	ENSPMGG00000017341	-	66	71.667	Periophthalmus_magnuspinnatus
ENSG00000169057	MECP2	98	100.000	ENSPEMG00000015115	Mecp2	100	95.501	Peromyscus_maniculatus_bairdii
ENSG00000169057	MECP2	98	100.000	ENSPCIG00000016390	MECP2	100	82.834	Phascolarctos_cinereus
ENSG00000169057	MECP2	52	86.207	ENSPFOG00000002307	mecp2	51	59.790	Poecilia_formosa
ENSG00000169057	MECP2	98	100.000	ENSPPYG00000020866	-	88	98.728	Pongo_abelii
ENSG00000169057	MECP2	97	92.373	ENSPCAG00000011826	MECP2	96	91.824	Procavia_capensis
ENSG00000169057	MECP2	100	98.196	ENSPCOG00000024848	MECP2	100	98.196	Propithecus_coquereli
ENSG00000169057	MECP2	74	97.810	ENSPVAG00000000472	MECP2	69	97.414	Pteropus_vampyrus
ENSG00000169057	MECP2	73	68.657	ENSPNAG00000024721	mecp2	50	61.702	Pygocentrus_nattereri
ENSG00000169057	MECP2	98	100.000	ENSRNOG00000056659	Mecp2	100	93.522	Rattus_norvegicus
ENSG00000169057	MECP2	100	99.588	ENSRBIG00000042958	MECP2	100	99.588	Rhinopithecus_bieti
ENSG00000169057	MECP2	100	99.588	ENSRROG00000044659	MECP2	100	99.588	Rhinopithecus_roxellana
ENSG00000169057	MECP2	100	99.177	ENSSBOG00000024999	MECP2	100	99.177	Saimiri_boliviensis_boliviensis
ENSG00000169057	MECP2	98	100.000	ENSSHAG00000007851	MECP2	100	81.964	Sarcophilus_harrisii
ENSG00000169057	MECP2	63	77.193	ENSSFOG00015001650	mecp2	73	70.430	Scleropages_formosus
ENSG00000169057	MECP2	98	100.000	ENSSARG00000012925	MECP2	100	90.776	Sorex_araneus
ENSG00000169057	MECP2	98	100.000	ENSSSCG00000034742	MECP2	99	88.660	Sus_scrofa
ENSG00000169057	MECP2	66	72.067	ENSTRUG00000006419	mecp2	61	60.073	Takifugu_rubripes
ENSG00000169057	MECP2	69	64.921	ENSTNIG00000005114	mecp2	98	49.195	Tetraodon_nigroviridis
ENSG00000169057	MECP2	98	100.000	ENSTTRG00000004653	MECP2	96	95.388	Tursiops_truncatus
ENSG00000169057	MECP2	98	100.000	ENSUAMG00000020446	MECP2	99	89.655	Ursus_americanus
ENSG00000169057	MECP2	100	97.561	ENSUMAG00000020747	-	100	95.349	Ursus_maritimus
ENSG00000169057	MECP2	98	100.000	ENSVVUG00000029591	MECP2	100	96.708	Vulpes_vulpes
ENSG00000169057	MECP2	87	90.476	ENSXETG00000014242	mecp2	100	64.826	Xenopus_tropicalis
ENSG00000169057	MECP2	72	69.072	ENSXCOG00000016461	mecp2	57	61.905	Xiphophorus_couchianus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0000785	chromatin	21873635.	IBA	Component
GO:0000792	heterochromatin	21873635.	IBA	Component
GO:0000792	heterochromatin	11441023.	IDA	Component
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	-	IEA	Function
GO:0001662	behavioral fear response	-	IEA	Process
GO:0001666	response to hypoxia	-	IEA	Process
GO:0001964	startle response	-	IEA	Process
GO:0001976	neurological system process involved in regulation of systemic arterial blood pressure	-	IEA	Process
GO:0002087	regulation of respiratory gaseous exchange by neurological system process	-	IEA	Process
GO:0003677	DNA binding	21873635.	IBA	Function
GO:0003714	transcription corepressor activity	10773092.	TAS	Function
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0003729	mRNA binding	-	IEA	Function
GO:0005515	protein binding	15696166.19820693.23770565.25609649.	IPI	Function
GO:0005615	extracellular space	22664934.	HDA	Component
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	11441023.21782149.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005739	mitochondrion	-	IEA	Component
GO:0005813	centrosome	25527496.	IMP	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0006020	inositol metabolic process	-	IEA	Process
GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c	-	IEA	Process
GO:0006342	chromatin silencing	-	IEA	Process
GO:0006349	regulation of gene expression by genetic imprinting	-	IEA	Process
GO:0006367	transcription initiation from RNA polymerase II promoter	-	TAS	Process
GO:0006541	glutamine metabolic process	-	IEA	Process
GO:0006576	cellular biogenic amine metabolic process	-	IEA	Process
GO:0007052	mitotic spindle organization	25527496.	IMP	Process
GO:0007416	synapse assembly	-	IEA	Process
GO:0007585	respiratory gaseous exchange	-	IEA	Process
GO:0007616	long-term memory	-	IEA	Process
GO:0008104	protein localization	-	IEA	Process
GO:0008134	transcription factor binding	-	IEA	Function
GO:0008211	glucocorticoid metabolic process	-	IEA	Process
GO:0008284	positive regulation of cell proliferation	25527496.	IMP	Process
GO:0008327	methyl-CpG binding	21873635.	IBA	Function
GO:0008344	adult locomotory behavior	-	IEA	Process
GO:0008542	visual learning	-	IEA	Process
GO:0009314	response to radiation	21873635.	IBA	Process
GO:0009405	pathogenesis	-	IEA	Process
GO:0009791	post-embryonic development	-	IEA	Process
GO:0010385	double-stranded methylated DNA binding	21873635.	IBA	Function
GO:0010385	double-stranded methylated DNA binding	17296936.	IMP	Function
GO:0010629	negative regulation of gene expression	23960241.	IDA	Process
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	25527496.	IMP	Process
GO:0016358	dendrite development	-	IEA	Process
GO:0016525	negative regulation of angiogenesis	23960241.	IMP	Process
GO:0016571	histone methylation	-	IEA	Process
GO:0016573	histone acetylation	-	IEA	Process
GO:0019230	proprioception	-	IEA	Process
GO:0019233	sensory perception of pain	-	IEA	Process
GO:0019904	protein domain specific binding	11441023.	IPI	Function
GO:0021549	cerebellum development	-	IEA	Process
GO:0021591	ventricular system development	-	IEA	Process
GO:0031061	negative regulation of histone methylation	-	IEA	Process
GO:0032048	cardiolipin metabolic process	-	IEA	Process
GO:0035067	negative regulation of histone acetylation	-	IEA	Process
GO:0035176	social behavior	-	IEA	Process
GO:0035197	siRNA binding	-	IEA	Function
GO:0042551	neuron maturation	-	IEA	Process
GO:0043524	negative regulation of neuron apoptotic process	-	IEA	Process
GO:0043537	negative regulation of blood vessel endothelial cell migration	23960241.	IDA	Process
GO:0045892	negative regulation of transcription, DNA-templated	11441023.	IDA	Process
GO:0045893	positive regulation of transcription, DNA-templated	-	IEA	Process
GO:0046470	phosphatidylcholine metabolic process	-	IEA	Process
GO:0047485	protein N-terminus binding	11441023.	IPI	Function
GO:0050432	catecholamine secretion	-	IEA	Process
GO:0051151	negative regulation of smooth muscle cell differentiation	-	IEA	Process
GO:0051965	positive regulation of synapse assembly	-	IEA	Process
GO:0060079	excitatory postsynaptic potential	-	IEA	Process
GO:0060291	long-term synaptic potentiation	-	IEA	Process
GO:0090063	positive regulation of microtubule nucleation	25527496.	IMP	Process
GO:0098794	postsynapse	-	IEA	Component
GO:1900114	positive regulation of histone H3-K9 trimethylation	-	IEA	Process
GO:1905643	positive regulation of DNA methylation	23960241.	IDA	Process
GO:2000820	negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation	-	IEA	Process

EuRBPDB

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

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Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.