EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
16341775ANT2 isoform required for cancer cell glycolysis.J Bioenerg Biomembr2005 OctChevrollier A-
15691486[What is the specific role of ANT2 in cancer cells?].Med Sci (Paris)2005 FebChevrollier A-
15486956ANT2 expression under hypoxic conditions produces opposite cell-cycle behavior in 143B and HepG2 cancer cells.Mol Carcinog2005 JanChevrollier A-
20060930The fourth isoform of the adenine nucleotide translocator inhibits mitochondrial apoptosis in cancer cells.Int J Biochem Cell Biol2010 MayGallerne Cdoi: 10.1016/j.biocel.2009.12.024
18267033Suppression of adenine nucleotide translocase-2 by vector-based siRNA in human breast cancer cells induces apoptosis and inhibits tumor growth in vitro and in vivo.Breast Cancer Res2008Jang JYdoi: 10.1186/bcr1857
17884777[Therapeutic effects of a recombinant adeno-associated virus expressing fusion peptide NT4p53(C22)Ant on ICR mice bearing transplanted liver cancer].Nan Fang Yi Ke Da Xue Xue Bao2007 SepZhou Q-
17855512Adenine nucleotide (ADP/ATP) translocase 3 participates in the tumor necrosis factor induced apoptosis of MCF-7 cells.Mol Biol Cell2007 NovYang Z-
16982757Chemosensitization by knockdown of adenine nucleotide translocase-2.Cancer Res2006 Sep 15Le Bras M-
23306701ANT2 suppression by shRNA restores miR-636 expression, thereby downregulating Ras and inhibiting tumorigenesis of hepatocellular carcinoma.Exp Mol Med2013 Jan 10Jang JYdoi: 10.1038/emm.2013.1.
20950584Adenine nucleotide translocase 2 is a key mitochondrial protein in cancer metabolism.Biochim Biophys Acta2011 JunChevrollier Adoi: 10.1016/j.bbabio.2010.10.008
28350139Upregulation of miR-137 reverses sorafenib resistance and cancer-initiating cell phenotypes by degrading ANT2 in hepatocellular carcinoma.Oncol Rep2017 AprLu AQdoi: 10.3892/or.2017.5498
26842067Changes in the expression of the human adenine nucleotide translocase isoforms condition cellular metabolic/proliferative status.Open Biol2016 FebGavalda-Navarro Adoi: 10.1098/rsob.150108.
26722601CISD2 associated with proliferation indicates negative prognosis in patients with hepatocellular carcinoma.Int J Clin Exp Pathol2015 Oct 1Chen B-
27458020ATP/ADP Turnover and Import of Glycolytic ATP into Mitochondria in Cancer Cells Is Independent of the Adenine Nucleotide Translocator.J Biol Chem2016 Sep 9Maldonado ENdoi: 10.1074/jbc.M116.734814
30226588Upregulation of liver kinase B1 predicts poor prognosis in hepatocellular carcinoma.Int J Oncol2018 NovTan Xdoi: 10.3892/ijo.2018.4556
30180193Significant predictors of overall survival in patients with hepatocellular carcinoma after surgical resection.PLoS One2018 Sep 4Lin CWdoi: 10.1371/journal.pone.0202650
25588739Evaluation of in vivo antitumor effects of ANT2 shRNA delivered using PEI and ultrasound with microbubbles.Gene Ther2015 AprPark DHdoi: 10.1038/gt.2014.120
29483454[Three Cases of Long-Term Surviving Stage IV Gastric Cancer after Conversion Surgery].Gan To Kagaku Ryoho2018 FebNukada S-
29961754Autophagy-related gene LC3 expression in tumor and liver microenvironments significantly predicts recurrence of hepatocellular carcinoma after surgical resection.Clin Transl Gastroenterol2018 Jul 2Lin CWdoi: 10.1038/s41424-018-0033-4.

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchrX1389596SilentNAY81Y0.05
BLCAchrX1386678Missense_MutationNAA274E0.67
BLCAchrX1389377SilentNAF154F0.08
BLCAchrX1387346Silentrs143974718A224A0.49
BRCAchrX1389512SilentNAF109F0.14
BRCAchrX1391922Missense_MutationNAE30Q0.23
BRCAchrX1389626Missense_MutationnovelW71C0.26
CESCchrX1389707Missense_MutationnovelQ44H0.37
CESCchrX1389482Silentrs140860839S119S0.21
CESCchrX13865503'UTRnovel0.21
CESCchrX1389479Silentrs150984574G120G0.42
CESCchrX1389566Missense_MutationnovelF91L0.08
CESCchrX13865403'UTRnovel0.26
CESCchrX1391922Missense_MutationnovelE30K0.3
COADchrX1389299Silentrs147304014S180S0.22
COADchrX1387352SilentNAA222A0.3
COADchrX1386648Frame_Shift_DelNAG284Afs*140.24
COADchrX1387343Silentrs774859439G225G0.27
COADchrX1391974Missense_MutationNAF12L0.38
COADchrX1386648Frame_Shift_DelNAG284Afs*140.16
COADchrX1389704Silentrs201788965I45I0.22
COADchrX1386706Missense_MutationNAE265K0.09
COADchrX1389238Splice_Regionnovel0.22
COADchrX13863963'UTRrs7658397450.25
ESCAchrX1387388Silentrs780007250I210I0.29
ESCAchrX1389263Silentrs191387595F192F0.47
GBMchrX1386641Silentrs763935099F286F0.08
GBMchrX13865283'UTRnovel0.95
GBMchrX1387388Silentrs780007250I210I0.62
HNSCchrX1386695SilentnovelK268K0.21
HNSCchrX1389725Splice_RegionnovelV38V0.14
HNSCchrX1387300Missense_Mutationrs755639289M240L0.6
KICHchrX1387368Missense_MutationnovelA217V0.27
KIRCchrX1386744Missense_Mutationrs143212891T252M0.34
LGGchrX1389441Missense_Mutationrs776487550P133L0.42
LIHCchrX1389426Missense_MutationnovelR138K0.4
LUADchrX1389403Nonsense_MutationnovelG146*0.23
LUADchrX1389262Missense_MutationNAG193C0.34
LUSCchrX1387324In_Frame_DelnovelG225_F231del0.05
LUSCchrX13864633'UTRnovel0.47
LUSCchrX1389389SilentnovelT150T0.15
LUSCchrX1386648Frame_Shift_DelNAG284Afs*140.24
LUSCchrX1386611Missense_MutationNAK296N0.42
OVchrX1389521Missense_MutationnovelH106Q0.18
PAADchrX1389293SilentnovelQ182Q0.18
PRADchrX1389495Missense_MutationnovelG115V0.24
PRADchrX1389497SilentnovelA114A0.24
READchrX1389474Missense_MutationnovelA122V0.44
READchrX1391955Missense_MutationnovelA19P0.16
SARCchrX1389725Splice_RegionnovelV38V0.41
SARCchrX1389430Missense_Mutationrs200654415A137T0.31
SARCchrX1386641Silentrs763935099F286F0.48
SKCMchrX1386653Missense_MutationNAM282I0.46
SKCMchrX1387370Silentrs750248666I216I0.27
SKCMchrX13865393'UTRnovel0.21
SKCMchrX13865403'UTRnovel0.2
SKCMchrX1387282Missense_MutationNAG246R0.29
SKCMchrX1389455SilentNAL128L0.08
STADchrX1387310SilentNAR236R0.26
STADchrX1386678Missense_Mutationrs778134725A274V0.11
STADchrX1389593Missense_MutationNAF82L0.1
STADchrX1389518Silentrs561919681T107T0.1
STADchrX1389522Missense_MutationNAH106R0.12
STADchrX1389518Silentrs561919681T107T0.42
STADchrX1386661Missense_MutationNAR280W0.32
UCECchrX1389385Missense_MutationNAR152C0.26
UCECchrX1389581SilentNAA86A0.3
UCECchrX1387348Missense_MutationnovelA224T0.3
UCECchrX1389641Silentrs766902588G66G0.36
UCECchrX1387325Silentrs147482209F231F0.33
UCECchrX1389263Silentrs191387595F192F0.33
UCECchrX13864843'UTRnovel0.34
UCECchrX13920425'UTRrs7527227730.39
UCECchrX1386679Missense_MutationNAA274T0.22
UCECchrX1386729Missense_MutationnovelC257Y0.2
UCECchrX1389259Missense_Mutationrs747278531V194M0.54
UCECchrX1389467Silentrs754243711G124G0.57
UCECchrX13865323'UTRnovel0.48
UCECchrX1391936Missense_MutationnovelA25V0.28
UCECchrX13864413'UTRnovel0.42
UCECchrX13865133'UTRnovel0.36
UCECchrX1389449Silentrs773200662F130F0.48
UCECchrX1387370Silentrs750248666I216I0.36
UCECchrX1389279Missense_MutationnovelY187C0.36
UCECchrX1389465Missense_Mutationrs764299940A125V0.39
UCECchrX1386677Silentrs374378029A274A0.38
UCECchrX1387370Silentrs750248666I216I0.35
UCECchrX1386661Missense_MutationNAR280W0.38
UCECchrX1387282Nonsense_MutationnovelG246*0.47
UCECchrX13864093'UTRnovel0.43
UCECchrX1389338Silentrs770300708S167S0.36
UCECchrX1389700Missense_Mutationrs748318861A47T0.32
UCECchrX13864603'UTRnovel0.3
UCECchrX1389698SilentnovelA47A0.35
UCECchrX1389676Missense_Mutationrs147287418V55M0.31
UCECchrX1386654Missense_MutationnovelM282T0.32
UCECchrX1387325Silentrs147482209F231F0.46
UCECchrX1391900Missense_MutationnovelQ37R0.37
UCECchrX1386743Silentrs773817849T252T0.35
UCECchrX13865293'UTRrs3763736830.28
UCECchrX1386646Missense_Mutationrs761751583A285T0.29
UCSchrX1389534Frame_Shift_DelNAG102Afs*610.38
UCSchrX1387325Silentrs147482209F231F0.26

Copy Number Variations (CNVs)
CancerTypeFreq Q-value

Survival Analysis
CancerP-value Q-value
MESO0.00021

Kaplan-Meier Survival Analysis

PAAD0.0026

Kaplan-Meier Survival Analysis

PCPG0.019

Kaplan-Meier Survival Analysis

BLCA0.013

Kaplan-Meier Survival Analysis

CESC0.02

Kaplan-Meier Survival Analysis

LIHC0.0043

Kaplan-Meier Survival Analysis

UVM0.00019

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000169100 (Gene tree)
Gene ID
293
Gene Symbol
SLC25A6
Alias
ANT3|AAC3|ANT3Y
Full Name
Solute Carrier Family 25 Member 6
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Minus strand
Length
5,995 bases
Position
chrX:1,386,152-1,392,146
Accession
10992
RBP type
non-canonical RBP
Summary
This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Jun 2013]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000381401SLC25A6-2012062-ENSP00000370808298 (aa)-P12236
ENST00000484026SLC25A6-203854--- (aa)--
ENST00000475167SLC25A6-202900--- (aa)--
Gene Model
Click here to download ENSG00000169100's gene model file
Pathways
Pathway IDPathway NameSource
hsa04020Calcium signaling pathwayKEGG
hsa04022cGMP-PKG signaling pathwayKEGG
hsa04217NecroptosisKEGG
hsa04218Cellular senescenceKEGG
hsa05012Parkinson diseaseKEGG
hsa05016Huntington diseaseKEGG
hsa05164Influenza AKEGG
hsa05166Human T-cell leukemia virus 1 infectionKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000169100's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0005471ATP:ADP antiporter activity21873635.IBAFunction
GO:0005471ATP:ADP antiporter activity2541251.NASFunction
GO:0005515protein binding21370995.21516116.24725412.25416956.IPIFunction
GO:0005634nucleus21630459.HDAComponent
GO:0005739mitochondrion20833797.HDAComponent
GO:0005739mitochondrion-IDAComponent
GO:0005743mitochondrial inner membrane-TASComponent
GO:0005744TIM23 mitochondrial import inner membrane translocase complex2541251.TASComponent
GO:0006626protein targeting to mitochondrion-TASProcess
GO:0006915apoptotic process-IEAProcess
GO:0015866ADP transport-IEAProcess
GO:0015867ATP transport-IEAProcess
GO:0016021integral component of membrane-IEAComponent
GO:0046732active induction of host immune response by virus-TASProcess
GO:0050796regulation of insulin secretion-TASProcess
GO:0055085transmembrane transport-IEAProcess
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us