EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BRCA	chr14	20781943	Missense_Mutation	NA	S82G	0.37	RnaseA
BRCA	chr14	20782253	3'UTR	novel		0.13
CESC	chr14	20781996	Silent	NA	V99V	0.45
COAD	chr14	20782071	Missense_Mutation	NA	F124L	0.44	RnaseA
COAD	chr14	20782288	3'UTR	novel		0.35
COAD	chr14	20782247	3'UTR	novel		0.35
COAD	chr14	20781975	Silent	novel	C92C	0.08
GBM	chr14	20782124	Missense_Mutation	novel	V142A	0.42	RnaseA
LGG	chr14	20782204	3'UTR	novel		0.62
LIHC	chr14	20782147	Missense_Mutation	novel	L150V	0.29
LUAD	chr14	20781974	Missense_Mutation	NA	C92Y	0.21	RnaseA
LUSC	chr14	20782111	Missense_Mutation	novel	P138S	0.33	RnaseA
OV	chr14	20781890	In_Frame_Ins	novel	N64delinsKEDFKGSC	0.05	RnaseA
OV	chr14	20781802	Missense_Mutation	NA	E35Q	0.22	RnaseA
OV	chr14	20782128	Silent	novel	P143P	0.05
SARC	chr14	20782451	3'UTR	novel		0.16
SKCM	chr14	20782109	Missense_Mutation	novel	P137L	0.75	RnaseA
SKCM	chr14	20782049	Missense_Mutation	novel	S117N	0.45	RnaseA
SKCM	chr14	20782082	Missense_Mutation	novel	A128V	0.32	RnaseA
SKCM	chr14	20782105	Missense_Mutation	rs775457002	D136N	0.14	RnaseA
SKCM	chr14	20782093	Missense_Mutation	rs748868196	P132S	0.51	RnaseA
STAD	chr14	20782030	Missense_Mutation	NA	Y111H	0.3	RnaseA
STAD	chr14	20781947	Missense_Mutation	NA	I83S	0.24	RnaseA
STAD	chr14	20781774	Silent	NA	P25P	0.19
UCEC	chr14	20782218	3'UTR	novel		0.42
UCEC	chr14	20782120	Silent	novel	L141L	0.44
UCEC	chr14	20781737	Missense_Mutation	NA	V13A	0.44
UCEC	chr14	20781697	Splice_Region	novel		0.41
UCEC	chr14	20781721	Missense_Mutation	novel	L8I	0.36
UCEC	chr14	20782357	3'UTR	novel		0.31
UCEC	chr14	20781778	Missense_Mutation	rs202041108	R27C	0.33
UCEC	chr14	20782043	Missense_Mutation	rs753980106	R115H	0.4	RnaseA
UCEC	chr14	20782085	Nonsense_Mutation	novel	*C129Wfs9**	0.09	RnaseA
UCEC	chr14	20782018	Missense_Mutation	novel	T107A	0.1	RnaseA
UCEC	chr14	20781889	Missense_Mutation	NA	N64Y	0.3	RnaseA
UCEC	chr14	20782273	3'UTR	novel		0.24
UCEC	chr14	20782166	3'UTR	novel		0.38
UCEC	chr14	20781854	Missense_Mutation	novel	G52D	0.52	RnaseA
UCEC	chr14	20781758	Missense_Mutation	novel	P20Q	0.26
UCEC	chr14	20781892	Missense_Mutation	novel	T65A	0.37	RnaseA

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	AMP	0.2778	0.056464
ACC	DEL	0.1444	0.19769
CHOL	DEL	0.3611	0.00040262
COAD	AMP	0.0599	0.030224
HNSC	DEL	0.1092	0.0025503
KIRP	DEL	0.1632	0.085174
LUAD	AMP	0.2403	6.849e-09
LUSC	AMP	0.2056	3.0539e-09
LUSC	DEL	0.2615	0.0082553
PAAD	DEL	0.0924	0.11332
READ	DEL	0.3697	0.0043084
TGCT	DEL	0.0733	0.11998
THCA	DEL	0.002	0.23456

Survival Analysis

Cancer	P-value	Q-value
SARC	0.041	Kaplan-Meier Survival Analysis
SKCM	0.00011	Kaplan-Meier Survival Analysis
CESC	0.0019	Kaplan-Meier Survival Analysis
LAML	0.0055	Kaplan-Meier Survival Analysis
UCEC	0.011	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.023	Kaplan-Meier Survival Analysis
UVM	0.00025	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000169413 (Gene tree)
Gene ID: 6039
Gene Symbol: RNASE6
Alias: RAD1|RNaseK6|RNS6
Full Name: ribonuclease A family member k6
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 1,417 bases
Position: chr14:20,781,051-20,782,467
Accession: 10048
RBP type: canonical RBP
Summary: The protein encoded by this gene is a member of the ribonuclease A superfamily and functions in the urinary tract. The protein has broad-spectrum antimicrobial activity against pathogenic bacteria. [provided by RefSeq, Nov 2014]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000302046	RnaseA	PF00074.20	3.6e-40	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000304677	RNASE6-201	1061	XM_017021566	ENSP00000302046	150 (aa)	XP_016877055	Q93091

Gene Model

Click here to download ENSG00000169413's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000169413	Urine	8E-8	23251661

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000169413's network

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000169413	RNASE6	83	34.351	ENSG00000129538	RNASE1	89	38.182
ENSG00000169413	RNASE6	91	53.285	ENSG00000165799	RNASE7	88	53.285
ENSG00000169413	RNASE6	87	45.255	ENSG00000169385	RNASE2	85	45.255
ENSG00000169413	RNASE6	77	37.705	ENSG00000258818	RNASE4	76	37.705
ENSG00000169413	RNASE6	98	55.102	ENSG00000173431	RNASE8	95	55.102
ENSG00000169413	RNASE6	87	43.382	ENSG00000169397	RNASE3	85	43.382

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000169413	RNASE6	95	53.472	ENSAMEG00000015757	-	93	53.472	Ailuropoda_melanoleuca
ENSG00000169413	RNASE6	89	56.391	ENSAMEG00000019835	-	95	58.042	Ailuropoda_melanoleuca
ENSG00000169413	RNASE6	95	41.958	ENSAMEG00000019679	-	95	41.958	Ailuropoda_melanoleuca
ENSG00000169413	RNASE6	91	70.803	ENSBTAG00000008792	RNASE6	88	71.324	Bos_taurus
ENSG00000169413	RNASE6	100	86.000	ENSCJAG00000009645	RNASE6	100	86.000	Callithrix_jacchus
ENSG00000169413	RNASE6	81	46.721	ENSCAFG00000005430	-	83	47.059	Canis_familiaris
ENSG00000169413	RNASE6	81	46.721	ENSCAFG00020014403	-	86	47.059	Canis_lupus_dingo
ENSG00000169413	RNASE6	91	70.803	ENSCHIG00000002321	-	88	71.324	Capra_hircus
ENSG00000169413	RNASE6	91	66.667	ENSCHIG00000012366	-	99	67.153	Capra_hircus
ENSG00000169413	RNASE6	87	38.519	ENSCAPG00000002796	-	90	37.681	Cavia_aperea
ENSG00000169413	RNASE6	85	67.969	ENSCAPG00000005724	-	88	66.176	Cavia_aperea
ENSG00000169413	RNASE6	87	38.519	ENSCPOG00000007078	-	90	37.681	Cavia_porcellus
ENSG00000169413	RNASE6	85	68.750	ENSCPOG00000035683	-	90	66.912	Cavia_porcellus
ENSG00000169413	RNASE6	85	47.328	ENSCPOG00000031798	-	74	46.763	Cavia_porcellus
ENSG00000169413	RNASE6	100	94.000	ENSCSAG00000000346	RNASE6	100	94.000	Chlorocebus_sabaeus
ENSG00000169413	RNASE6	98	73.469	ENSCHOG00000011390	RNASE6	88	74.074	Choloepus_hoffmanni
ENSG00000169413	RNASE6	100	95.333	ENSCANG00000038226	RNASE6	100	95.333	Colobus_angolensis_palliatus
ENSG00000169413	RNASE6	91	67.647	ENSCGRG00001015115	Rnase6	89	67.647	Cricetulus_griseus_chok1gshd
ENSG00000169413	RNASE6	91	67.647	ENSCGRG00000013781	-	89	67.647	Cricetulus_griseus_crigri
ENSG00000169413	RNASE6	91	67.647	ENSCGRG00000018520	-	89	67.647	Cricetulus_griseus_crigri
ENSG00000169413	RNASE6	97	70.345	ENSETEG00000011242	RNASE6	95	70.345	Echinops_telfairi
ENSG00000169413	RNASE6	87	66.667	ENSEASG00005002955	RNASE6	88	65.693	Equus_asinus_asinus
ENSG00000169413	RNASE6	59	75.281	ENSECAG00000011733	RNASE6	64	73.404	Equus_caballus
ENSG00000169413	RNASE6	89	62.222	ENSEEUG00000012260	RNASE6	94	63.265	Erinaceus_europaeus
ENSG00000169413	RNASE6	91	61.029	ENSFCAG00000027531	RNASE6	95	63.014	Felis_catus
ENSG00000169413	RNASE6	85	55.639	ENSFDAG00000013623	-	88	54.815	Fukomys_damarensis
ENSG00000169413	RNASE6	85	71.875	ENSFDAG00000016194	-	87	71.756	Fukomys_damarensis
ENSG00000169413	RNASE6	86	45.385	ENSFDAG00000003158	-	88	45.038	Fukomys_damarensis
ENSG00000169413	RNASE6	100	98.667	ENSGGOG00000024921	RNASE6	100	98.667	Gorilla_gorilla
ENSG00000169413	RNASE6	82	52.000	ENSHGLG00000019869	-	91	50.746	Heterocephalus_glaber_female
ENSG00000169413	RNASE6	80	53.279	ENSHGLG00000019819	-	91	52.239	Heterocephalus_glaber_female
ENSG00000169413	RNASE6	85	67.969	ENSHGLG00000002261	RNASE6	87	68.182	Heterocephalus_glaber_female
ENSG00000169413	RNASE6	82	51.200	ENSHGLG00100019535	-	91	50.000	Heterocephalus_glaber_male
ENSG00000169413	RNASE6	80	53.279	ENSHGLG00100019557	-	91	52.239	Heterocephalus_glaber_male
ENSG00000169413	RNASE6	85	67.969	ENSHGLG00100004376	RNASE6	87	68.182	Heterocephalus_glaber_male
ENSG00000169413	RNASE6	98	74.150	ENSSTOG00000013234	RNASE6	96	74.150	Ictidomys_tridecemlineatus
ENSG00000169413	RNASE6	91	63.235	ENSLAFG00000008643	-	95	64.384	Loxodonta_africana
ENSG00000169413	RNASE6	91	70.588	ENSLAFG00000001918	-	95	71.233	Loxodonta_africana
ENSG00000169413	RNASE6	100	95.333	ENSMFAG00000005448	RNASE6	100	95.333	Macaca_fascicularis
ENSG00000169413	RNASE6	100	95.333	ENSMMUG00000001657	RNASE6	100	95.333	Macaca_mulatta
ENSG00000169413	RNASE6	100	95.333	ENSMNEG00000037956	RNASE6	100	95.333	Macaca_nemestrina
ENSG00000169413	RNASE6	91	64.706	ENSMAUG00000003090	Rnase6	89	64.706	Mesocricetus_auratus
ENSG00000169413	RNASE6	91	65.693	ENSMOCG00000000062	Rnase6	89	65.693	Microtus_ochrogaster
ENSG00000169413	RNASE6	91	67.647	MGP_CAROLIEiJ_G0019219	Rnase6	89	67.647	Mus_caroli
ENSG00000169413	RNASE6	91	65.441	ENSMUSG00000021880	Rnase6	89	65.441	Mus_musculus
ENSG00000169413	RNASE6	91	66.176	MGP_PahariEiJ_G0030244	Rnase6	89	66.176	Mus_pahari
ENSG00000169413	RNASE6	91	66.912	MGP_SPRETEiJ_G0020112	Rnase6	89	66.912	Mus_spretus
ENSG00000169413	RNASE6	89	60.902	ENSMPUG00000018384	-	95	62.238	Mustela_putorius_furo
ENSG00000169413	RNASE6	91	76.471	ENSMLUG00000005517	-	97	75.333	Myotis_lucifugus
ENSG00000169413	RNASE6	87	73.846	ENSMLUG00000024801	-	100	73.973	Myotis_lucifugus
ENSG00000169413	RNASE6	89	68.657	ENSMLUG00000007195	-	90	68.243	Myotis_lucifugus
ENSG00000169413	RNASE6	97	61.486	ENSMLUG00000024054	-	87	63.910	Myotis_lucifugus
ENSG00000169413	RNASE6	89	73.684	ENSNGAG00000012627	Rnase6	90	74.265	Nannospalax_galili
ENSG00000169413	RNASE6	100	95.333	ENSNLEG00000007523	RNASE6	100	95.333	Nomascus_leucogenys
ENSG00000169413	RNASE6	90	66.667	ENSOPRG00000003171	RNASE6	87	66.667	Ochotona_princeps
ENSG00000169413	RNASE6	90	77.778	ENSOCUG00000007494	RNASE6	95	76.871	Oryctolagus_cuniculus
ENSG00000169413	RNASE6	100	77.333	ENSOGAG00000007769	RNASE6	100	76.667	Otolemur_garnettii
ENSG00000169413	RNASE6	91	71.533	ENSOARG00000012752	-	88	72.059	Ovis_aries
ENSG00000169413	RNASE6	91	66.906	ENSOARG00000013263	-	88	67.391	Ovis_aries
ENSG00000169413	RNASE6	100	98.667	ENSPPAG00000033349	RNASE6	100	98.667	Pan_paniscus
ENSG00000169413	RNASE6	91	63.971	ENSPPRG00000020014	RNASE6	95	65.753	Panthera_pardus
ENSG00000169413	RNASE6	90	63.704	ENSPTIG00000004112	RNASE6	95	65.068	Panthera_tigris_altaica
ENSG00000169413	RNASE6	100	99.333	ENSPTRG00000006104	RNASE6	100	99.333	Pan_troglodytes
ENSG00000169413	RNASE6	100	96.000	ENSPPYG00000005577	RNASE6	100	96.000	Pongo_abelii
ENSG00000169413	RNASE6	85	64.062	ENSPCAG00000012414	RNASE6	95	63.699	Procavia_capensis
ENSG00000169413	RNASE6	91	69.118	ENSPVAG00000013559	RNASE6	88	69.118	Pteropus_vampyrus
ENSG00000169413	RNASE6	89	64.179	ENSRNOG00000025597	Rnase6	89	63.971	Rattus_norvegicus
ENSG00000169413	RNASE6	89	64.179	ENSRNOG00000055367	LOC103694852	89	63.971	Rattus_norvegicus
ENSG00000169413	RNASE6	100	95.333	ENSRBIG00000011937	RNASE6	100	95.333	Rhinopithecus_bieti
ENSG00000169413	RNASE6	89	67.407	ENSSARG00000009543	RNASE6	97	65.563	Sorex_araneus
ENSG00000169413	RNASE6	91	77.206	ENSTTRG00000010670	RNASE6	97	75.333	Tursiops_truncatus
ENSG00000169413	RNASE6	89	56.391	ENSUAMG00000004168	-	95	58.042	Ursus_americanus
ENSG00000169413	RNASE6	95	48.951	ENSUAMG00000004069	-	93	48.951	Ursus_americanus
ENSG00000169413	RNASE6	91	57.664	ENSUAMG00000011108	-	95	59.184	Ursus_americanus
ENSG00000169413	RNASE6	73	60.000	ENSUAMG00000011271	-	93	60.000	Ursus_americanus
ENSG00000169413	RNASE6	81	49.180	ENSUMAG00000002356	-	79	51.515	Ursus_maritimus
ENSG00000169413	RNASE6	89	55.639	ENSUMAG00000002357	-	94	55.782	Ursus_maritimus
ENSG00000169413	RNASE6	91	68.382	ENSVPAG00000011244	-	89	68.382	Vicugna_pacos
ENSG00000169413	RNASE6	91	68.382	ENSVPAG00000007374	-	89	68.382	Vicugna_pacos
ENSG00000169413	RNASE6	82	45.528	ENSVVUG00000009062	-	87	46.753	Vulpes_vulpes
ENSG00000169413	RNASE6	87	44.275	ENSVVUG00000009057	-	78	44.118	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003676	nucleic acid binding	-	IEA	Function
GO:0004519	endonuclease activity	-	IEA	Function
GO:0004540	ribonuclease activity	21873635.	IBA	Function
GO:0004540	ribonuclease activity	9826755.	IDA	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005615	extracellular space	25075772.	IDA	Component
GO:0005764	lysosome	-	IEA	Component
GO:0006401	RNA catabolic process	8836175.	TAS	Process
GO:0006952	defense response	8836175.	TAS	Process
GO:0019730	antimicrobial humoral response	-	TAS	Process
GO:0019731	antibacterial humoral response	25075772.	IDA	Process
GO:0031410	cytoplasmic vesicle	25075772.	IDA	Component
GO:0045087	innate immune response	25075772.	IDA	Process
GO:0050829	defense response to Gram-negative bacterium	25075772.	IDA	Process
GO:0050830	defense response to Gram-positive bacterium	25075772.	IDA	Process
GO:0051607	defense response to virus	9826755.	IDA	Process
GO:0051607	defense response to virus	9826755.	IDA	Process
GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	25075772.	IDA	Process
GO:0090501	RNA phosphodiester bond hydrolysis	9826755.	IDA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.