EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
30078000The RNA-Binding Protein PCBP1 Functions as a Tumor Suppressor in Prostate Cancer by Inhibiting Mitogen Activated Protein Kinase 1.Cell Physiol Biochem2018Zhang Ydoi: 10.1159/000492315
26880484Poly C binding protein 1 represses autophagy through downregulation of LC3B to promote tumor cell apoptosis in starvation.Int J Biochem Cell Biol2016 AprZhang Wdoi: 10.1016/j.biocel.2016.02.009
25661993Poly r(C) binding protein-1 is central to maintenance of cancer stem cells in prostate cancer cells.Cell Physiol Biochem2015Chen Qdoi: 10.1159/000373931
27683057MicroRNA-490 regulates lung cancer metastasis by targeting poly r(C)-binding protein 1.Tumour Biol2016 NovLi J-
24889597PCBP1 is an important mediator of TGF-β-induced epithelial to mesenchymal transition in gall bladder cancer cell line GBC-SD.Mol Biol Rep2014 AugZhang HYdoi: 10.1007/s11033-014-3428-7
12431987The 3'-untranslated region of p21WAF1 mRNA is a composite cis-acting sequence bound by RNA-binding proteins from breast cancer cells, including HuR and poly(C)-binding protein.J Biol Chem2003 Jan 31Giles KM-
12011088Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA.J Biol Chem2002 Jul 26Yeap BB-
24848140Serum one-carbon metabolites and risk of cervical cancer.Nutr Cancer2014Pathak Sdoi: 10.1080/01635581.2014.916318
20609352PCBP1 suppresses the translation of metastasis-associated PRL-3 phosphatase.Cancer Cell2010 Jul 13Wang Hdoi: 10.1016/j.ccr.2010.04.028.
25612617HOTAIR Long Noncoding RNA Promotes Gastric Cancer Metastasis through Suppression of Poly r(C)-Binding Protein (PCBP) 1.Mol Cancer Ther2015 MayZhang ZZdoi: 10.1158/1535-7163.MCT-14-0695
28076324Poly(C)-binding protein 1 mediates drug resistance in colorectal cancer.Oncotarget2017 Feb 21Guo Jdoi: 10.18632/oncotarget.14516.
27746021Direct Regulation of Alternative Splicing by SMAD3 through PCBP1 Is Essential to the Tumor-Promoting Role of TGF-β.Mol Cell2016 Nov 3Tripathi Vdoi: 10.1016/j.molcel.2016.09.013
28963376Poly r(C) binding protein (PCBP) 1 expression is regulated by the E3 ligase UBE4A in thyroid carcinoma.Biosci Rep2017 Oct 31Zhang MPdoi: 10.1042/BSR20170114
28560430Fyn/heterogeneous nuclear ribonucleoprotein E1 signaling regulates pancreatic cancer metastasis by affecting the alternative splicing of integrin β1.Int J Oncol2017 JulJiang Pdoi: 10.3892/ijo.2017.4018

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr270087892Missense_MutationnovelS50L0.42
BLCAchr270088398Missense_MutationnovelL219V0.42
BLCAchr270088658Silentrs769538150I305I0.39
BLCAchr270088503Missense_MutationnovelG254R0.36
BLCAchr270087756Missense_MutationNAV5M0.13
BLCAchr270088539Missense_MutationnovelE266K0.16
BLCAchr270088350Missense_MutationNAD203N0.09
BLCAchr2700877085'UTRnovel0.36
BLCAchr270088772Missense_MutationnovelI343M0.47KH_1
BLCAchr270088515Missense_MutationnovelA258S0.35
BLCAchr270087864Missense_MutationnovelE41K0.28
BLCAchr270088610SilentnovelN289N0.09
BLCAchr270088411Missense_Mutationrs757437176S223L0.45
BRCAchr270087762Missense_MutationNAE7Q0.16
CESCchr270088142SilentNAV133V0.32
CESCchr270087894Missense_MutationnovelE51K0.38
COADchr270088042Missense_MutationNAL100Q0.33
COADchr2700876925'UTRnovel0.26
COADchr270088419Missense_MutationNAG226R0.14
COADchr270088042Missense_MutationNAL100Q0.39
COADchr270088042Missense_MutationNAL100P0.39
COADchr2700890123'UTRnovel0.29
COADchr270088614Missense_MutationnovelI291V0.28KH_1
COADchr270088042Missense_MutationNAL100Q0.33
COADchr270088048Missense_MutationNAL102P0.38
COADchr270088042Missense_MutationNAL100Q0.17
COADchr270088042Missense_MutationNAL100Q0.31
COADchr270088042Missense_MutationNAL100Q0.36
COADchr270088048Missense_MutationNAL102P0.38
COADchr270088048Missense_MutationnovelL102R0.13
COADchr270087929Silentrs201447568T62T0.32
COADchr270088048Missense_MutationNAL102Q0.47
COADchr270088048Missense_MutationNAL102P0.41
COADchr2700888433'UTRnovel0.06
COADchr270088042Missense_MutationNAL100Q0.29
ESCAchr2700889243'UTRnovel0.14
GBMchr270088261Missense_MutationnovelS173Y0.22
GBMchr270088492Missense_MutationnovelM250K0.75
HNSCchr270088350Missense_MutationNAD203N0.37
HNSCchr270088204Missense_MutationnovelS154Y0.39
HNSCchr270088700SilentnovelV319V0.32
KIRCchr270087972Missense_MutationNAD77Y0.1
KIRPchr270088386Nonsense_MutationnovelE215*0.47
KIRPchr270087818SilentNAV25V0.25
LGGchr2700877205'UTRnovel0.36
LGGchr270088776Missense_MutationNAA345P0.25
LIHCchr270087858Missense_MutationnovelI39L0.27
LIHCchr2700889103'UTRnovel0.29
LIHCchr270088042Missense_MutationNAL100Q0.36
LIHCchr270088781Missense_MutationnovelR346S0.54
LIHCchr270088491Missense_Mutationrs548418658M250V0.16
LUADchr270088791Missense_MutationnovelE350Q0.12
LUADchr270087806Missense_MutationNAH21Q0.3
LUADchr270088789Missense_MutationnovelS349F0.19
LUADchr270087772Missense_MutationnovelL10R0.23
LUSCchr270088196SilentnovelV151V0.14
LUSCchr2700876745'UTRrs5511842920.2
LUSCchr270088412SilentnovelS223S0.09
LUSCchr270088244SilentnovelL167L0.3
LUSCchr270087859Missense_MutationnovelI39S0.09
LUSCchr270088554Frame_Shift_DelnovelW271Mfs*160.17
MESOchr270088442SilentnovelL233L0.33
OVchr270087806Missense_MutationNAH21Q0.17
OVchr270087759Missense_MutationnovelT6S0.11
PAADchr270087991Missense_MutationnovelI83S0.25
PAADchr270088173Missense_MutationnovelR144W0.26
PAADchr270088810Missense_MutationnovelS356I0.23
READchr270088557Missense_MutationNAA272S0.38
READchr270088242Missense_MutationNAL167M0.22
READchr270088042Missense_MutationNAL100Q0.61
READchr270088042Missense_MutationNAL100Q0.33
READchr270088761Missense_MutationnovelQ340K0.23KH_1
READchr270088048Missense_MutationNAL102Q0.52
READchr270088042Missense_MutationNAL100Q0.37
READchr270088042Missense_MutationNAL100Q0.46
READchr270087790Missense_MutationNAI16N0.39
READchr270088048Missense_MutationNAL102Q0.15
SKCMchr270088257Missense_MutationnovelQ172K0.06
SKCMchr270087790Missense_MutationnovelI16T0.32
SKCMchr270087903Missense_MutationnovelC54S0.26
SKCMchr2700888413'UTRnovel0.26
SKCMchr270087851SilentNAV36V0.45
STADchr270088690Missense_MutationNAA316V0.3KH_1
STADchr270088711Missense_MutationNAS323F0.16KH_1
STADchr270088801Frame_Shift_InsnovelC355Vfs*110.45
STADchr270087990Missense_MutationNAI83F0.08
THCAchr270088042Missense_MutationNAL100Q0.04
UCECchr270088777Missense_MutationNAA345V0.13
UCECchr270087890SilentNAI49I0.33
UCECchr270088799SilentnovelG352G0.21
UCECchr270088024Missense_MutationnovelS94N0.44
UCECchr270087748Missense_MutationnovelD2G0.09
UCECchr2700888473'UTRnovel0.21
UCECchr270088551Missense_MutationNAY270D0.19
UCECchr270088386Missense_MutationNAE215Q0.26
UCECchr2700891983'UTRnovel0.38
UCECchr270087880Missense_MutationnovelR46L0.53
UCECchr2700889223'UTRnovel0.71
UCECchr2700890433'UTRnovel0.18
UCECchr270087947SilentnovelI68I0.32
UCECchr2700891673'UTRnovel0.24
UCECchr270088777Missense_MutationNAA345V0.37
UCECchr270088333Missense_MutationnovelG197D0.19
UCECchr270087773SilentnovelL10L0.41
UCECchr2700888273'UTRnovel0.43

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
KIRPDEL0.02430.08832
PAADDEL0.04890.2014
READDEL0.06670.19022

Survival Analysis
CancerP-value Q-value
THYM0.013

Kaplan-Meier Survival Analysis

STAD0.026

Kaplan-Meier Survival Analysis

MESO0.0074

Kaplan-Meier Survival Analysis

COAD0.021

Kaplan-Meier Survival Analysis

CESC0.042

Kaplan-Meier Survival Analysis

LAML0.0029

Kaplan-Meier Survival Analysis

UCEC0.033

Kaplan-Meier Survival Analysis

CHOL0.037

Kaplan-Meier Survival Analysis

LUAD0.023

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • RBPome
  • PRI
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Paralogs
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000169564 (Gene tree)
Gene ID
5093
Gene Symbol
PCBP1
Alias
HNRPE1|hnRNP-E1|HNRPX|hnRNP-X
Full Name
poly(rC) binding protein 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
1,751 bases
Position
chr2:70,087,453-70,089,203
Accession
8647
RBP type
canonical RBP
Summary
This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000305556KH_1PF00013.295.7e-5113
ENSP00000305556KH_1PF00013.295.7e-5123
ENSP00000305556KH_1PF00013.295.7e-5133
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8
Protein-RNA interaction(RNA-Binding Site)
Click here to download all RNA binding sites
Click here to download all RNA binding sites

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
17068759Identification and analysis of altered alpha1,6-fucosylated glycoproteins associated with hepatocellular carcinoma metastasis.Proteomics2006 NovDai Z-
10608888The N-terminal K homology domain of the poly(rC)-binding protein is a major determinant for binding to the poliovirus 5'-untranslated region and acts as an inhibitor of viral translation.J Biol Chem1999 Dec 31Silvera D-
27836661Phosphorylation of poly(rC) binding protein 1 (PCBP1) contributes to stabilization of mu opioid receptor (MOR) mRNA via interaction with AU-rich element RNA-binding protein 1 (AUF1) and poly A binding protein (PABP).Gene2017 Jan 20Hwang CKdoi: 10.1016/j.gene.2016.11.003
16087907Messenger RNA degradation may be inhibited in sporadic inclusion body myositis.Neurology2005 Aug 9Nakano S-
15731341Structure and RNA binding of the third KH domain of poly(C)-binding protein 1.Nucleic Acids Res2005 Feb 24Sidiqi M-
15246275A posttranscriptional regulator of Kaposi's sarcoma-associated herpesvirus interacts with RNA-binding protein PCBP1 and controls gene expression through the IRES.Virology2004 Aug 1Nishimura K-
19193997Crystallization and preliminary crystallographic analysis of the second RRM of Pub1 from Saccharomyces cerevisiae.Acta Crystallogr Sect F Struct Biol Cryst Commun2009 Feb 1Cui Ydoi: 10.1107/S1744309108040682
20418951Molecular basis of eRF3 recognition by the MLLE domain of poly(A)-binding protein.PLoS One2010 Apr 14Kozlov Gdoi: 10.1371/journal.pone.0010169.
23587065Stress granules in neurodegeneration--lessons learnt from TAR DNA binding protein of 43 kDa and fused in sarcoma.FEBS J2013 SepBentmann Edoi: 10.1111/febs.12287
27102006PCBP1/HNRNP E1 Protects Chromosomal Integrity by Translational Regulation of CDC27.Mol Cancer Res2016 JulLink LAdoi: 10.1158/1541-7786.MCR-16-0018
28611064Cytoplasmic poly(A)-binding protein 1 (PABPC1) interacts with the RNA-binding protein hnRNPLL and thereby regulates immunoglobulin secretion in plasma cells.J Biol Chem2017 Jul 21Peng Ydoi: 10.1074/jbc.M117.794834
21930702Incrimination of heterogeneous nuclear ribonucleoprotein E1 (hnRNP-E1) as a candidate sensor of physiological folate deficiency.J Biol Chem2011 Nov 11Tang YSdoi: 10.1074/jbc.M111.230938
18656558Identification of transcripts and translatants targeted by overexpressed PCBP1.Biochim Biophys Acta2008 NovHuo LRdoi: 10.1016/j.bbapap.2008.06.017
20519371The poly(c)-binding protein-1 regulates expression of the androgen receptor.Endocrinology2010 AugCloke Bdoi: 10.1210//en.2009-1264
24489926PolyC-binding protein 1 interacts with 5'-untranslated region of enterovirus 71 RNA in membrane-associated complex to facilitate viral replication.PLoS One2014 Jan 29Luo Zdoi: 10.1371/journal.pone.0087491
28077174Mutant HSPB1 causes loss of translational repression by binding to PCBP1, an RNA binding protein with a possible role in neurodegenerative disease.Acta Neuropathol Commun2017 Jan 11Geuens Tdoi: 10.1186/s40478-016-0407-3.
28617947Poly r(C) binding protein 1-mediated regulation of microRNA expression underlies post-sevoflurane amelioration of acute lung injury in rats.J Cell Physiol2018 AprZhao Xdoi: 10.1002/jcp.26053
29138420Expression of both poly r(C) binding protein 1 (PCBP1) and miRNA-3978 is suppressed in peritoneal gastric cancer metastasis.Sci Rep2017 Nov 14Ji FJdoi: 10.1038/s41598-017-15448-9.
30086790PCBP1 depletion promotes tumorigenesis through attenuation of p27Kip1 mRNA stability and translation.J Exp Clin Cancer Res2018 Aug 7Shi Hdoi: 10.1186/s13046-018-0840-1.
7556077Identification of two KH domain proteins in the alpha-globin mRNP stability complex.EMBO J1995 Sep 1Kiledjian M-
19727228Identification of novel partner proteins of PCBP1.Beijing Da Xue Xue Bao Yi Xue Ban2009 Aug 18Huo LR-
17389360Signaling-dependent and coordinated regulation of transcription, splicing, and translation resides in a single coregulator, PCBP1.Proc Natl Acad Sci U S A2007 Apr 3Meng Q-
20609352PCBP1 suppresses the translation of metastasis-associated PRL-3 phosphatase.Cancer Cell2010 Jul 13Wang Hdoi: 10.1016/j.ccr.2010.04.028.
20584894Heterogeneous nuclear ribonucleoproteins (hnRNPs) in cellular processes: Focus on hnRNP E1's multifunctional regulatory roles.RNA2010 AugChaudhury Adoi: 10.1261/rna.2254110
27292014Post-Transcriptional Regulation of the Human Mu-Opioid Receptor (MOR) by Morphine-Induced RNA Binding Proteins hnRNP K and PCBP1.J Cell Physiol2017 MarSong KYdoi: 10.1002/jcp.25455
24480778Specific enrichment of the RNA-binding proteins PCBP1 and PCBP2 in chief cells of the murine gastric mucosa.Gene Expr Patterns2014 MarGhanem LRdoi: 10.1016/j.gep.2014.01.004
23938467Linking spermatid ribonucleic acid (RNA) binding protein and retrogene diversity to reproductive success.Mol Cell Proteomics2013 NovChapman KMdoi: 10.1074/mcp.M113.030585
23864636Magnetic fractionation and proteomic dissection of cellular organelles occupied by the late replication complexes of Semliki Forest virus.J Virol2013 SepVarjak Mdoi: 10.1128/JVI.01105-13
28512205Phorbol-12-myristate-13-acetate-mediated stabilization of leukemia inhibitory factor (lif) mRNA: involvement of Nucleolin and PCBP1.Biochem J2017 Jul 3Chakraborty Adoi: 10.1042/BCJ20170051.
28735747A Requirement for Mena, an Actin Regulator, in Local mRNA Translation in Developing Neurons.Neuron2017 Aug 2Vidaki Mdoi: 10.1016/j.neuron.2017.06.048
29958803Iron Drives T Helper Cell Pathogenicity by Promoting RNA-Binding Protein PCBP1-Mediated Proinflammatory Cytokine Production.Immunity2018 Jul 17Wang Zdoi: 10.1016/j.immuni.2018.05.008
30078000The RNA-Binding Protein PCBP1 Functions as a Tumor Suppressor in Prostate Cancer by Inhibiting Mitogen Activated Protein Kinase 1.Cell Physiol Biochem2018Zhang Ydoi: 10.1159/000492315
30626936TGF-β-induced alternative splicing of TAK1 promotes EMT and drug resistance.Oncogene2019 AprTripathi Vdoi: 10.1038/s41388-018-0655-8
15169918Bag-1 internal ribosome entry segment activity is promoted by structural changes mediated by poly(rC) binding protein 1 and recruitment of polypyrimidine tract binding protein 1.Mol Cell Biol2004 JunPickering BM-
21402597Cellular cap-binding proteins associate with influenza virus mRNAs.J Gen Virol2011 JulBier Kdoi: 10.1099/vir.0.029231-0
8999938Preferential binding of poly(A)-binding protein 1 to an inhibitory RNA element in the human immunodeficiency virus type 1 gag mRNA.J Biol Chem1997 Jan 24Afonina E-
30247716Enterovirus 71 antagonizes the inhibition of the host intrinsic antiviral factor A3G.Nucleic Acids Res2018 Nov 30Li Zdoi: 10.1093/nar/gky840.
17928403Epidermal growth factor increases the interaction between nucleolin and heterogeneous nuclear ribonucleoprotein K/poly(C) binding protein 1 complex to regulate the gastrin mRNA turnover.Mol Biol Cell2007 DecLee PT-
21957477Is there a classical nonsense-mediated decay pathway in trypanosomes?PLoS One2011Delhi Pdoi: 10.1371/journal.pone.0025112
26339052Doubly Spliced RNA of Hepatitis B Virus Suppresses Viral Transcription via TATA-Binding Protein and Induces Stress Granule Assembly.J Virol2015 NovTsai KNdoi: 10.1128/JVI.00949-15
28977530Nuclear poly(A) binding protein 1 (PABPN1) and Matrin3 interact in muscle cells and regulate RNA processing.Nucleic Acids Res2017 Oct 13Banerjee Adoi: 10.1093/nar/gkx786.
28825698A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression.Nat Cell Biol2017 SepGrelet Sdoi: 10.1038/ncb3595
29891675Specific binding of PCBP1 to heavily oxidized RNA to induce cell death.Proc Natl Acad Sci U S A2018 Jun 26Ishii Tdoi: 10.1073/pnas.1806912115
31326364Two ways of escaping from oxidative RNA damage: Selective degradation and cell death.DNA Repair (Amst)2019 Jul 8:102666Ishii Tdoi: 10.1016/j.dnarep.2019.102666
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000303577PCBP1-2011750-ENSP00000305556356 (aa)-Q15365
Gene Model
Click here to download ENSG00000169564's gene model file
Pathways
Pathway IDPathway NameSource
hsa03040SpliceosomeKEGG
hsa04216FerroptosisKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000169564's network

* RBP PPI network refers to all genes directly bind to RBP
Paralogs
Ensembl IDGene SymbolCoverageIdentiy ParalogGene SymbolCoverageIdentiy
ENSG00000169564PCBP16031.466ENSG00000107164FUBP37530.830
ENSG00000169564PCBP17040.541ENSG00000139910NOVA17535.135
ENSG00000169564PCBP18840.187ENSG00000165119HNRNPK9045.455
ENSG00000169564PCBP15632.143ENSG00000073792IGF2BP27633.696
ENSG00000169564PCBP16641.558ENSG00000104967NOVA25141.558
ENSG00000169564PCBP16434.667ENSG00000088247KHSRP9934.722
ENSG00000169564PCBP19968.407ENSG00000183570PCBP39968.407
ENSG00000169564PCBP110082.834ENSG00000197111PCBP210093.038
ENSG00000169564PCBP19852.691ENSG00000090097PCBP49768.712
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000169564PCBP110097.191ENSAMEG00000016094PCBP110097.191Ailuropoda_melanoleuca
ENSG00000169564PCBP110085.674ENSANAG00000033377-10085.674Aotus_nancymaae
ENSG00000169564PCBP18987.658ENSANAG00000027108-10087.658Aotus_nancymaae
ENSG00000169564PCBP17995.053ENSANAG00000019364-10095.053Aotus_nancymaae
ENSG00000169564PCBP110089.045ENSANAG00000023938-10089.045Aotus_nancymaae
ENSG00000169564PCBP17995.053ENSANAG00000031745-10095.053Aotus_nancymaae
ENSG00000169564PCBP110088.202ENSANAG00000026077-10088.202Aotus_nancymaae
ENSG00000169564PCBP19796.243ENSANAG00000026989-9996.243Aotus_nancymaae
ENSG00000169564PCBP17991.873ENSANAG00000022494-10091.873Aotus_nancymaae
ENSG00000169564PCBP191100.000ENSBTAG00000008985PCBP199100.000Bos_taurus
ENSG00000169564PCBP110094.382ENSCJAG00000038388-9594.382Callithrix_jacchus
ENSG00000169564PCBP110099.719ENSCAFG00000003326PCBP110099.719Canis_familiaris
ENSG00000169564PCBP1100100.000ENSCHIG00000007923PCBP1100100.000Capra_hircus
ENSG00000169564PCBP110099.438ENSTSYG00000027848PCBP110099.438Carlito_syrichta
ENSG00000169564PCBP1100100.000ENSCPOG00000013511PCBP1100100.000Cavia_porcellus
ENSG00000169564PCBP1100100.000ENSCCAG00000019842-100100.000Cebus_capucinus
ENSG00000169564PCBP110091.292ENSCCAG00000029186-9891.292Cebus_capucinus
ENSG00000169564PCBP1100100.000ENSCATG00000015029PCBP1100100.000Cercocebus_atys
ENSG00000169564PCBP110099.438ENSCLAG00000017909PCBP110099.438Chinchilla_lanigera
ENSG00000169564PCBP1100100.000ENSCSAG00000019441PCBP1100100.000Chlorocebus_sabaeus
ENSG00000169564PCBP110089.888ENSCANG00000032470-9489.888Colobus_angolensis_palliatus
ENSG00000169564PCBP1100100.000ENSCANG00000018039-100100.000Colobus_angolensis_palliatus
ENSG00000169564PCBP17284.706ENSCANG00000033810-8784.706Colobus_angolensis_palliatus
ENSG00000169564PCBP1100100.000ENSCGRG00001015078Pcbp1100100.000Cricetulus_griseus_chok1gshd
ENSG00000169564PCBP1100100.000ENSCGRG00000018899Pcbp1100100.000Cricetulus_griseus_crigri
ENSG00000169564PCBP18099.298ENSDNOG00000036372PCBP19999.298Dasypus_novemcinctus
ENSG00000169564PCBP1100100.000ENSDORG00000008216Pcbp1100100.000Dipodomys_ordii
ENSG00000169564PCBP1100100.000ENSFCAG00000022238PCBP1100100.000Felis_catus
ENSG00000169564PCBP110099.719ENSFDAG00000019637PCBP110099.719Fukomys_damarensis
ENSG00000169564PCBP1100100.000ENSGGOG00000028130PCBP1100100.000Gorilla_gorilla
ENSG00000169564PCBP110099.719ENSHGLG00000020345Pcbp110099.719Heterocephalus_glaber_female
ENSG00000169564PCBP110097.753ENSHGLG00000020243-10097.753Heterocephalus_glaber_female
ENSG00000169564PCBP110099.438ENSHGLG00100019620-10099.438Heterocephalus_glaber_male
ENSG00000169564PCBP110099.719ENSHGLG00100019761Pcbp110099.719Heterocephalus_glaber_male
ENSG00000169564PCBP1100100.000ENSSTOG00000026002PCBP1100100.000Ictidomys_tridecemlineatus
ENSG00000169564PCBP1100100.000ENSJJAG00000000737Pcbp1100100.000Jaculus_jaculus
ENSG00000169564PCBP19588.427ENSMFAG00000003400PCBP110088.427Macaca_fascicularis
ENSG00000169564PCBP1100100.000ENSMMUG00000038295PCBP1100100.000Macaca_mulatta
ENSG00000169564PCBP1100100.000ENSMNEG00000002934PCBP1100100.000Macaca_nemestrina
ENSG00000169564PCBP1100100.000ENSMLEG00000027389PCBP1100100.000Mandrillus_leucophaeus
ENSG00000169564PCBP110099.719ENSMAUG00000009843Pcbp110099.719Mesocricetus_auratus
ENSG00000169564PCBP1100100.000ENSMICG00000038221PCBP1100100.000Microcebus_murinus
ENSG00000169564PCBP1100100.000ENSMOCG00000008102Pcbp1100100.000Microtus_ochrogaster
ENSG00000169564PCBP1100100.000MGP_CAROLIEiJ_G0028598Pcbp1100100.000Mus_caroli
ENSG00000169564PCBP1100100.000ENSMUSG00000051695Pcbp1100100.000Mus_musculus
ENSG00000169564PCBP1100100.000MGP_PahariEiJ_G0022335Pcbp1100100.000Mus_pahari
ENSG00000169564PCBP1100100.000MGP_SPRETEiJ_G0029609Pcbp1100100.000Mus_spretus
ENSG00000169564PCBP110097.191ENSMPUG00000007175PCBP110097.191Mustela_putorius_furo
ENSG00000169564PCBP1100100.000ENSMLUG00000014173PCBP1100100.000Myotis_lucifugus
ENSG00000169564PCBP1100100.000ENSNGAG00000014909-100100.000Nannospalax_galili
ENSG00000169564PCBP1100100.000ENSNGAG00000011957-100100.000Nannospalax_galili
ENSG00000169564PCBP1100100.000ENSNLEG00000018722PCBP1100100.000Nomascus_leucogenys
ENSG00000169564PCBP110083.427ENSODEG00000000263PCBP110083.427Octodon_degus
ENSG00000169564PCBP1100100.000ENSOCUG00000003634PCBP1100100.000Oryctolagus_cuniculus
ENSG00000169564PCBP110097.191ENSOGAG00000028946PCBP110097.191Otolemur_garnettii
ENSG00000169564PCBP1100100.000ENSOARG00000019516PCBP1100100.000Ovis_aries
ENSG00000169564PCBP110098.034ENSPPAG00000036116PCBP19998.599Pan_paniscus
ENSG00000169564PCBP1100100.000ENSPPRG00000020533PCBP1100100.000Panthera_pardus
ENSG00000169564PCBP1100100.000ENSPTIG00000007318PCBP1100100.000Panthera_tigris_altaica
ENSG00000169564PCBP1100100.000ENSPTRG00000012025PCBP1100100.000Pan_troglodytes
ENSG00000169564PCBP1100100.000ENSPANG00000011314PCBP1100100.000Papio_anubis
ENSG00000169564PCBP1100100.000ENSPPYG00000012328PCBP1100100.000Pongo_abelii
ENSG00000169564PCBP1100100.000ENSPCOG00000026934PCBP1100100.000Propithecus_coquereli
ENSG00000169564PCBP110099.157ENSRROG00000009684-9599.157Rhinopithecus_roxellana
ENSG00000169564PCBP19398.795ENSRROG00000012514-10098.795Rhinopithecus_roxellana
ENSG00000169564PCBP110083.427ENSSBOG00000035309-9483.427Saimiri_boliviensis_boliviensis
ENSG00000169564PCBP110099.719ENSSSCG00000027224PCBP110099.719Sus_scrofa
ENSG00000169564PCBP151100.000ENSTBEG00000015706-51100.000Tupaia_belangeri
ENSG00000169564PCBP19199.690ENSVVUG00000028033PCBP19999.690Vulpes_vulpes
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000398mRNA splicing, via spliceosome-TASProcess
GO:0000981DNA-binding transcription factor activity, RNA polymerase II-specific-IEAFunction
GO:0003697single-stranded DNA binding8152927.IDAFunction
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0003723RNA binding7556077.7607214.8152927.IDAFunction
GO:0003729mRNA binding14722620.IDAFunction
GO:0005515protein binding16713569.17389360.20374249.21994455.22028648.22365833.22673507.25416956.IPIFunction
GO:0005654nucleoplasm-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005737cytoplasm25468996.IDAComponent
GO:0005829cytosol-IDAComponent
GO:0016020membrane19946888.HDAComponent
GO:0016070RNA metabolic process-TASProcess
GO:0016607nuclear speck-IDAComponent
GO:0036464cytoplasmic ribonucleoprotein granule-IDAComponent
GO:0039694viral RNA genome replication12414943.IDAProcess
GO:0045296cadherin binding25468996.HDAFunction
GO:0045944positive regulation of transcription by RNA polymerase II-IEAProcess
GO:0070062extracellular exosome19056867.20458337.23533145.HDAComponent
GO:0098847sequence-specific single stranded DNA binding-IEAFunction
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