EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
28639885MicroRNA-195 inhibits the proliferation and invasion of pancreatic cancer cells by targeting the fatty acid synthase/Wnt signaling pathway.Tumour Biol2017 JunXu Zdoi: 10.1177/1010428317711324.
21922386Overexpression of fatty acid synthase in human urinary bladder cancer and combined expression of the synthase and Ki-67 as a predictor of prognosis of cancer patients.Med Mol Morphol2011 SepSugino Tdoi: 10.1007/s00795-010-0517-0
15235125Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells.Proc Natl Acad Sci U S A2004 Jul 20Menendez JA-
25958981Global gene deregulations in FASN silenced retinoblastoma cancer cells: molecular and clinico-pathological correlations.J Cell Biochem2015 NovSangeetha Mdoi: 10.1002/jcb.25217.
15897909FAS expression inversely correlates with PTEN level in prostate cancer and a PI 3-kinase inhibitor synergizes with FAS siRNA to induce apoptosis.Oncogene2005 Aug 11Bandyopadhyay S-
26425687Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression.EBioMedicine2015 Jul 2Ventura Rdoi: 10.1016/j.ebiom.2015.06.020
24789255Overexpression of fatty acid synthase in human gliomas correlates with the WHO tumor grade and inhibition with Orlistat reduces cell viability and triggers apoptosis.J Neurooncol2014 JunGrube Sdoi: 10.1007/s11060-014-1452-z
23142364Regulation of fatty acid synthase (FAS) and apoptosis in estrogen-receptor positive and negative breast cancer cells by conjugated linoleic acids.Prostaglandins Leukot Essent Fatty Acids2012 DecSong HJdoi: 10.1016/j.plefa.2012.09.002
25871544Diacylglycerol Metabolism and Signaling Is a Driving Force Underlying FASN Inhibitor Sensitivity in Cancer Cells.ACS Chem Biol2015 Jul 17Benjamin DIdoi: 10.1021/acschembio.5b00240
12646257Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains.Biochem Biophys Res Commun2003 Mar 21Swinnen JV-
20228782Serous tubal intraepithelial carcinoma upregulates markers associated with high-grade serous carcinomas including Rsf-1 (HBXAP), cyclin E and fatty acid synthase.Mod Pathol2010 JunSehdev ASdoi: 10.1038/modpathol.2010.60
23135268G protein-coupled estrogen receptor mediates the up-regulation of fatty acid synthase induced by 17β-estradiol in cancer cells and cancer-associated fibroblasts.J Biol Chem2012 Dec 21Santolla MFdoi: 10.1074/jbc.M112.417303
12939396Fatty acid synthase expression defines distinct molecular signatures in prostate cancer.Mol Cancer Res2003 AugRossi S-
23064941Usefulness of immunohistochemical expression analysis of metabolic-related molecules in differentiating between intracranial neoplastic and non-neoplastic lesions.Brain Tumor Pathol2013 JulMakino Kdoi: 10.1007/s10014-012-0120-2
21726077The lipogenesis pathway as a cancer target.J Med Chem2011 Aug 25Abramson HNdoi: 10.1021/jm2005805
21442130Overexpression of fatty acid synthase in Middle Eastern epithelial ovarian carcinoma activates AKT and Its inhibition potentiates cisplatin-induced apoptosis.Mol Med2011Uddin Sdoi: 10.2119/molmed.2011.00046
22127986Early growth response 1 and fatty acid synthase expression is altered in tumor adjacent prostate tissue and indicates field cancerization.Prostate2012 Aug 1Jones ACdoi: 10.1002/pros.22465
15254710Inhibition of tumor-associated fatty acid synthase activity enhances vinorelbine (Navelbine)-induced cytotoxicity and apoptotic cell death in human breast cancer cells.Oncol Rep2004 AugMenendez JA-
24510238Cancer cell-associated fatty acid synthase activates endothelial cells and promotes angiogenesis in colorectal cancer.Carcinogenesis2014 JunZaytseva YYdoi: 10.1093/carcin/bgu042
18211286Overexpression of fatty acid synthase gene activates HER1/HER2 tyrosine kinase receptors in human breast epithelial cells.Cell Prolif2008 FebVazquez-Martin Adoi: 10.1111/j.1365-2184.2007.00498.x.
28339092MACC1 decreases the chemosensitivity of gastric cancer cells to oxaliplatin by regulating FASN expression.Oncol Rep2017 MayDuan Jdoi: 10.3892/or.2017.5519
29130104Expression of fatty acid synthase is regulated by PGC1α and contributes to increased cell proliferation.Oncol Rep2017 DecYun SHdoi: 10.3892/or.2017.6044
25947066Fatty acid synthase overexpression: target for therapy and reversal of chemoresistance in ovarian cancer.J Transl Med2015 May 7Bauerschlag DOdoi: 10.1186/s12967-015-0511-3.
18820672Characterization of a novel anti-fatty acid synthase (FASN) antiserum in breast tissue.Mod Pathol2008 DecJensen KCdoi: 10.1038/modpathol.2008.163
24907642Novel nuclear localization of fatty acid synthase correlates with prostate cancer aggressiveness.Am J Pathol2014 AugMadigan AAdoi: 10.1016/j.ajpath.2014.04.012
26025399Molecular events are associated with resistance to vinblastine in bladder cancer.Cell Mol Biol (Noisy-le-grand)2015 May 8Chen Q-
12839976RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells.Cancer Res2003 Jul 1De Schrijver E-
19467222Interaction between fatty acid synthase- and ErbB-systems in ovarian cancer cells.Biochem Biophys Res Commun2009 Jul 31Grunt TWdoi: 10.1016/j.bbrc.2009.05.085
26514456Expression of Fatty Acid Synthase Negatively Correlates with PTEN and Predicts Peritoneal Dissemination of Human Gastric Cancer.Asian Pac J Cancer Prev2015Xiang HG-
18955444Cohort study of fatty acid synthase expression and patient survival in colon cancer.J Clin Oncol2008 Dec 10Ogino Sdoi: 10.1200/JCO.2008.18.2675
17488603[Transcriptional activities of human fatty acid synthase promoter in breast cancer cells].Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi2007 MayChen Y-
23317220Inhibitory effects of onion (Allium cepa L.) extract on proliferation of cancer cells and adipocytes via inhibiting fatty acid synthase.Asian Pac J Cancer Prev2012Wang Y-
26951539Prolyl hydroxylase mediated inhibition of fatty acid synthase to combat tumor growth in mammary gland carcinoma.Breast Cancer2016 NovSingh M-
19885560Fatty acid synthase activity regulates HER2 extracellular domain shedding into the circulation of HER2-positive metastatic breast cancer patients.Int J Oncol2009 DecVazquez-Martin A-
18838960Overexpression of fatty acid synthase is associated with palmitoylation of Wnt1 and cytoplasmic stabilization of beta-catenin in prostate cancer.Lab Invest2008 DecFiorentino Mdoi: 10.1038/labinvest.2008.97
14689581Fatty acid synthase: a metabolic oncogene in prostate cancer?J Cell Biochem2004 Jan 1Baron A-
24200503Fatty acid synthase plays a role in cancer metabolism beyond providing fatty acids for phospholipid synthesis or sustaining elevations in glycolytic activity.Exp Cell Res2014 Jan 15Hopperton KEdoi: 10.1016/j.yexcr.2013.10.016
12515624[Significance of fatty acid synthase expression in non-small cell lung cancer].Zhonghua Zhong Liu Za Zhi2002 MayWang Y-
17687193Fatty acid synthase hyperactivation in human colorectal cancer: relationship with tumor side and sex.Oncology2006Notarnicola M-
23982110Fatty acid synthase expression is strongly related to menopause in early-stage breast cancer patients.Menopause2014 FebPorta Rdoi: 10.1097/GME.0b013e31829d17dc.
12531699Regulation of fatty acid synthase expression in breast cancer by sterol regulatory element binding protein-1c.Exp Cell Res2003 Jan 15Yang Yu-
20546348Comparison of the diagnostic value of fatty acid synthase (FASN) with alpha-methylacyl-CoA racemase (AMACR) as prostatic cancer tissue marker.Histopathology2010 MayTischler Vdoi: 10.1111/j.1365-2559.2010.03535.x.
21970855Blockade of fatty acid synthase induces ubiquitination and degradation of phosphoinositide-3-kinase signaling proteins in ovarian cancer.Mol Cancer Res2011 DecTomek Kdoi: 10.1158/1541-7786.MCR-10-0467
19621387Sp1 coordinately regulates de novo lipogenesis and proliferation in cancer cells.Int J Cancer2010 Jan 15Lu Sdoi: 10.1002/ijc.24761.
19318631Fatty acid synthase: a metabolic enzyme and candidate oncogene in prostate cancer.J Natl Cancer Inst2009 Apr 1Migita Tdoi: 10.1093/jnci/djp030
23306391Fatty acid synthase is a potential therapeutic target in estrogen receptor-/progesterone receptor-positive endometrioid endometrial cancer.Oncology2013Rahman MTdoi: 10.1159/000342967
25173531Fatty acid synthase/oxidized low-density lipoprotein as metabolic oncogenes linking obesity to colon cancer via NF-kappa B in Egyptians.Med Oncol2014 OctKeshk WAdoi: 10.1007/s12032-014-0192-4
18281512A new mechanism of drug resistance in breast cancer cells: fatty acid synthase overexpression-mediated palmitate overproduction.Mol Cancer Ther2008 FebLiu Hdoi: 10.1158/1535-7163.MCT-07-0445.
19032940AMPK-sensed cellular energy state regulates the release of extracellular Fatty Acid Synthase.Biochem Biophys Res Commun2009 Jan 16Oliveras-Ferraros Cdoi: 10.1016/j.bbrc.2008.11.067
25227797Fatty acid synthesis pathway genetic variants and clinical outcome of non-small cell lung cancer patients after surgery.Asian Pac J Cancer Prev2014Jin X-
21044743Increased fatty acid synthase activity in non-small cell lung cancer tissue is a weaker predictor of shorter patient survival than increased lipoprotein lipase activity.Arch Med Res2010 AugCerne Ddoi: 10.1016/j.arcmed.2010.08.007.
25151963Fatty acid synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell death.Oncogene2015 JunYang CSdoi: 10.1038/onc.2014.271
26109148Loss of fatty acid synthase suppresses the malignant phenotype of colorectal cancer cells by down-regulating energy metabolism and mTOR signaling pathway.J Cancer Res Clin Oncol2016 JanChang Ldoi: 10.1007/s00432-015-2000-8
17631500Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells.J Biol Chem2007 Sep 7Yoon S-
19252981Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk.Breast Cancer Res Treat2009 DecCampa Ddoi: 10.1007/s10549-009-0347-8
25433947Expressions of fatty acid synthase and HER2 are correlated with poor prognosis of ovarian cancer.Med Oncol2015 JanCai Ydoi: 10.1007/s12032-014-0391-z
23725225 activity and malignant phenotype of Caco-2 cells.Lipids Health Dis2013 Jun 1Li Ndoi: 10.1186/1476-511X-12-83.
22266115Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer.Cancer Res2012 Mar 15Zaytseva YYdoi: 10.1158/0008-5472.CAN-11-4057
15556626Vitamin D3 inhibits fatty acid synthase expression by stimulating the expression of long-chain fatty-acid-CoA ligase 3 in prostate cancer cells.FEBS Lett2004 Nov 19Qiao S-
26107737Dual fatty acid synthase and HER2 signaling blockade shows marked antitumor activity against breast cancer models resistant to anti-HER2 drugs.PLoS One2015 Jun 24Blancafort Adoi: 10.1371/journal.pone.0131241
20657182High levels of fatty acid synthase expression in esophageal cancers represent a potential target for therapy.Cancer Biol Ther2010 Sep 15Orita Hdoi: 10.4161/cbt.10.6.12727
19358283Increased expression of fatty acid synthase in human aberrant crypt foci: possible target for colorectal cancer prevention.Int J Cancer2009 Jul 1Kearney KEdoi: 10.1002/ijc.24356.
19083124Aromatase, CYP1B1 and fatty acid synthase expression in breast tumors of BRCA1 mutation carriers.Pathol Oncol Res2009 SepBerstein LMdoi: 10.1007/s12253-008-9137-6.
27939887B7-H3 regulates lipid metabolism of lung cancer through SREBP1-mediated expression of FASN.Biochem Biophys Res Commun2017 Jan 22Luo Ddoi: 10.1016/j.bbrc.2016.12.021
27357679Sleeping Beauty screen reveals Pparg activation in metastatic prostate cancer.Proc Natl Acad Sci U S A2016 Jul 19Ahmad Idoi: 10.1073/pnas.1601571113
26934656P300 acetyltransferase regulates fatty acid synthase expression, lipid metabolism and prostate cancer growth.Oncotarget2016 Mar 22Gang Xdoi: 10.18632/oncotarget.7715.
27713175Fatty acid synthase is a primary target of MiR-15a and MiR-16-1 in breast cancer.Oncotarget2016 Nov 29Wang Jdoi: 10.18632/oncotarget.12479.
27714708Clinical and therapeutic relevance of the metabolic oncogene fatty acid synthase in HER2+ breast cancer.Histol Histopathol2017 JulCorominas-Faja Bdoi: 10.14670/HH-11-830
27579768Leucine deprivation inhibits proliferation and induces apoptosis of human breast cancer cells via fatty acid synthase.Oncotarget2016 Sep 27Xiao Fdoi: 10.18632/oncotarget.11626.
28418352[Fatty acid synthase in the diagnosis of prostate neoplasms].Arkh Patol2017Allina DOdoi: 10.17116/patol201779210-14.
30256698In silico screening for identification of fatty acid synthase inhibitors and evaluation of their antiproliferative activity using human cancer cell lines.J Recept Signal Transduct Res2018 AugNisthul A Adoi: 10.1080/10799893.2018.1511730

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1782081742Missense_MutationnovelA2089T0.4
BLCAchr1782089376SilentnovelV658V0.12
BLCAchr1782085580SilentnovelL1342L0.36
BLCAchr1782084265Missense_Mutationrs746519327P1630S0.14
BLCAchr1782087498Missense_Mutationrs373840426S1017L0.09
BLCAchr1782087978Missense_MutationnovelE948Q0.23
BLCAchr1782091010Missense_MutationnovelD518Y0.18
BLCAchr1782079470Missense_MutationnovelA2429T0.27
BLCAchr1782082150Missense_MutationNAE2008K0.19
BLCAchr1782095455Missense_Mutationrs774656123R49W0.49
BLCAchr1782087831Missense_MutationnovelP966H0.32
BLCAchr1782079464Missense_MutationnovelE2431K0.75
BLCAchr1782083364Silentrs775171713N1801N0.79
BLCAchr1782084581Missense_MutationnovelY1567C0.19
BLCAchr1782091273Missense_MutationnovelE481Q0.54
BLCAchr1782089038Missense_MutationnovelF745L0.31
BLCAchr1782093760Missense_MutationnovelD98H0.22
BRCAchr1782079365Missense_MutationnovelL2464V0.25
BRCAchr1782089292Missense_MutationnovelF686L0.1
BRCAchr1782089385Splice_SiteNAX656_splice0.2
BRCAchr1782085523Missense_MutationnovelT1361A0.15
BRCAchr1782082030Frame_Shift_DelnovelC2045Afs*260.1
BRCAchr1782080853Missense_MutationnovelL2222Q0.14
BRCAchr1782093316SilentNAG186G0.2
BRCAchr1782080804Missense_MutationNAQ2238H0.35
BRCAchr1782081299SilentNAL2154L0.19
BRCAchr1782093642Missense_Mutationrs759072039R137Q0.31
BRCAchr1782083808Frame_Shift_InsnovelF1728Gfs*220.16
BRCAchr1782089010In_Frame_DelnovelP753_E754del0.27
BRCAchr1782082145Silentrs377318289A2009A0.34
BRCAchr1782088210Missense_MutationNAK897N0.22
BRCAchr1782081670Missense_MutationNAE2113K0.25
BRCAchr1782082409Missense_MutationNAL1975F0.32
BRCAchr1782083236Missense_MutationNAA1844D0.32
BRCAchr1782091517Silentrs375098618N399N0.5
BRCAchr1782095438Silentrs146398649L54L0.26
BRCAchr1782083556Missense_MutationNAE1768K0.45
BRCAchr1782082548Silentrs763862356G1966G0.16
BRCAchr1782083830Silentrs138389856F1720F0.23
CESCchr1782085397Silentrs201599707A1376A0.47
CESCchr1782083350Frame_Shift_DelnovelD1806Afs*600.07
CESCchr1782091051Missense_Mutationrs41283367R504H0.19
CESCchr1782091371Frame_Shift_InsnovelL448Hfs*290.33
CESCchr1782091373SilentnovelD447D0.33
CESCchr1782079507SilentnovelL2416L0.24
CESCchr1782080202Missense_MutationNAE2362K0.27
CESCchr1782089261Nonsense_MutationnovelE697*0.09
CESCchr1782083610Missense_MutationNAE1750K0.25
CESCchr1782084682SilentNAV1533V0.3
CESCchr1782085617SilentNAL1329L0.17
CESCchr1782088454Frame_Shift_DelnovelD843Efs*500.08
CESCchr1782092707Frame_Shift_InsnovelT295Sfs*670.2
CESCchr1782092709SilentnovelG294G0.2
CESCchr1782088559SilentnovelI808I0.29
CESCchr1782091529Silentrs770772130F395F0.17
CESCchr1782093250Silentrs45624241P208P0.27
CESCchr1782084805Missense_MutationNAE1520Q0.41
CESCchr1782083370Missense_MutationNAF1799L0.29
CESCchr1782082939SilentNAL1914L0.35
CESCchr1782083199Splice_Regionrs7778931930.37
COADchr1782091056Missense_MutationNAQ502H0.72
COADchr1782085035Missense_MutationNAR1470L0.23
COADchr1782083541Missense_MutationNAD1773N0.13
COADchr1782085369Missense_MutationNAL1386M0.31
COADchr1782091564Missense_Mutationrs762823912R384C0.29
COADchr1782085688Missense_Mutationrs751832838A1306T0.29
COADchr1782088559SilentnovelI808I0.41
COADchr1782084647Missense_Mutationrs41283363R1545H0.23
COADchr1782089312Missense_MutationNAM680L0.28
COADchr1782085400Splice_Regionrs17848940D1375D0.16
COADchr1782086547Missense_MutationNAA1147T0.43
COADchr1782091246Missense_Mutationrs533081221R490C0.36
COADchr1782083312Missense_Mutationrs369955820R1819W0.07
COADchr1782081206Missense_Mutationrs372065783R2185W0.42
COADchr1782095358Missense_MutationNAL81P0.33
COADchr1782087169Missense_MutationNAP1103L0.44
COADchr1782082658Missense_MutationNAR1930S0.27
COADchr1782091428Missense_MutationNAR429H0.25
COADchr1782079376Missense_Mutationrs751413369A2460V0.34
COADchr1782090391SilentNAG618G0.43
COADchr1782091478Frame_Shift_DelNAA413Hfs*390.43
COADchr1782081197Nonsense_MutationNAQ2188*0.26
COADchr1782085257Missense_Mutationrs748110849R1423H0.61
COADchr1782088409SilentnovelS858S0.14
COADchr1782091052Missense_Mutationrs758221850R504C0.11
COADchr1782092755Missense_Mutationrs377076774S279L0.24
COADchr1782086500Silentrs781538664P1162P0.46
COADchr1782083523Missense_MutationNAP1779S0.46
COADchr1782089271SilentNAP693P0.12
COADchr1782090380Missense_MutationNAA622V0.26
COADchr1782082637Missense_Mutationrs17848945V1937I0.24
COADchr1782092465Missense_MutationNAA340V0.2
COADchr1782089672Missense_MutationNAC642Y0.7
COADchr1782081164Missense_Mutationrs747906170E2199K0.6
COADchr1782091529Silentrs770772130F395F0.14
COADchr1782091478Frame_Shift_DelNAA413Hfs*390.52
COADchr1782082920Missense_Mutationrs142537824R1921W0.34
COADchr1782082026Missense_Mutationrs373838349R2049Q0.55
COADchr1782080695Nonsense_MutationNAR2275*0.04
COADchr1782088555Missense_MutationNAA810T0.5
COADchr1782084601Silentrs777624347G1560G0.11
COADchr1782093625Missense_MutationNAR143W0.1
COADchr1782084892Missense_MutationNAA1491S0.52
COADchr1782083595Missense_MutationNAA1755T0.3
COADchr1782082062Missense_MutationNAA2037V0.35
COADchr1782084528Missense_MutationNAP1585T0.24
COADchr1782091049Missense_Mutationrs778595263G505R0.29
DLBCchr1782088793Missense_MutationnovelF796L0.38
ESCAchr1782088207Silentrs373471307T898T0.23
ESCAchr1782079253Missense_Mutationrs1140623V2476I0.17
ESCAchr1782084528Missense_Mutationrs765330213P1585S0.16
ESCAchr1782085638Silentrs765948097L1322L0.09
ESCAchr1782088406Silentrs778504673A859A0.56
ESCAchr1782091032Splice_SitenovelX498_splice0.29
ESCAchr1782080547SilentnovelI2290I0.12
ESCAchr1782083304SilentnovelG1821G0.4
GBMchr1782080406Silentrs144647991F2337F0.64
GBMchr1782080892Missense_MutationnovelG2209V0.44
GBMchr1782082659SilentnovelV1929V0.45
GBMchr1782086438Missense_Mutationrs776209432S1183L0.53
GBMchr1782080166Missense_MutationnovelQ2374E0.41
GBMchr1782079449Missense_MutationnovelK2436Q0.28
HNSCchr1782087425Silentrs146226779S1041S0.18
HNSCchr1782083013Missense_Mutationrs139792253A1890T0.08
HNSCchr1782086406Missense_MutationnovelL1194V0.33
HNSCchr1782079244Missense_MutationnovelG2479S0.07
HNSCchr1782088264SilentnovelT879T0.48
HNSCchr1782093600Missense_MutationnovelR151K0.15
HNSCchr1782088123Silentrs369562322P926P0.15
HNSCchr1782096340Missense_Mutationrs754942049D36N0.11
HNSCchr1782083393Missense_Mutationrs750492722H1792Y0.43
HNSCchr1782085399Missense_Mutationrs374469081A1376T0.16
HNSCchr1782083363Missense_Mutationrs764921764E1802K0.15
HNSCchr1782089029SilentnovelA748A0.58
HNSCchr1782091615Missense_MutationnovelP367S0.16
HNSCchr1782088021SilentnovelL933L0.32
HNSCchr1782085602SilentnovelA1334A0.06
KIRCchr1782087109Missense_Mutationrs760902072T1123M0.05
KIRCchr1782088870SilentNAL771L0.3
KIRCchr1782082560SilentnovelL1962L0.28
KIRCchr1782083783Missense_MutationNAT1736M0.26
KIRCchr1782082060Missense_MutationNAN2038H0.19
KIRCchr1782083381Missense_MutationnovelL1796M0.25
KIRCchr1782089378In_Frame_DelnovelA656_P657del0.23
KIRPchr1782089292SilentnovelF686F0.54
KIRPchr1782089727Splice_SiteNAX624_splice0.19
KIRPchr1782083537Missense_MutationNAL1774R0.1
KIRPchr1782080742Missense_MutationNAS2259N0.24
KIRPchr1782092957Missense_MutationNAR240W0.41
KIRPchr1782095324Silentrs568118566D92D0.14
LGGchr1782082068Missense_MutationnovelG2035D0.07
LGGchr1782095408SilentnovelF64F0.3
LGGchr1782093716Silentrs775026834S112S0.37
LGGchr1782083055Missense_Mutationrs768785119I1876V0.57
LIHCchr1782087379Missense_Mutationrs141517558I1057V0.3
LIHCchr1782079406Missense_Mutationrs776351410T2450M0.27
LIHCchr1782082031Missense_MutationNAK2047N0.23
LIHCchr1782080172Missense_MutationnovelV2372L0.47
LIHCchr1782082963SilentNAQ1906Q0.3
LIHCchr1782085309Missense_MutationnovelP1406S0.29
LIHCchr1782093308Missense_MutationnovelN189T0.34
LIHCchr1782087153SilentNAE1108E0.47
LIHCchr1782093615Missense_MutationNAF146S0.49
LIHCchr1782092913Frame_Shift_DelnovelT253Rfs*310.44
LIHCchr1782080741SilentnovelS2259S0.26
LIHCchr1782087069Missense_MutationnovelE1136D0.29
LIHCchr1782093615Missense_MutationNAF146S0.08
LIHCchr1782091516Missense_Mutationrs771740708V400M0.11
LIHCchr1782085540Missense_MutationnovelD1355V0.12
LIHCchr1782084275SilentnovelV1626V0.09
LIHCchr1782081228SilentNAR2177R0.63
LIHCchr1782083323Missense_MutationnovelQ1815P0.28
LIHCchr1782093747Missense_MutationNAG102E0.61
LIHCchr1782083551SilentnovelI1769I0.33
LIHCchr1782083083SilentNAK1866K0.51
LIHCchr1782080852SilentnovelL2222L0.08
LIHCchr1782081216SilentNAQ2181Q0.21
LIHCchr1782092707Missense_MutationNAT295I0.35
LIHCchr1782089372Nonsense_MutationNAE660*0.17
LIHCchr1782081250Frame_Shift_DelnovelL2170Pfs*480.27
LUADchr1782087239Missense_MutationNAV1080L0.46
LUADchr1782082095Missense_Mutationrs769327857R2026H0.87
LUADchr1782083579Missense_MutationNAL1760S0.41
LUADchr1782088229Missense_MutationnovelY891F0.26
LUADchr1782095409Missense_MutationnovelF64S0.25
LUADchr1782083389Missense_MutationNAG1793V0.32
LUADchr1782087813Missense_Mutationrs202024339P972L0.26
LUADchr1782092753Missense_MutationnovelA280P0.16
LUADchr1782088449Missense_Mutationrs756471902P845L0.27
LUADchr1782079538Missense_MutationnovelK2406R0.14
LUADchr1782091410Missense_Mutationrs766211253Q435R0.53
LUADchr1782079251SilentNAV2476V0.19
LUADchr1782093344Missense_MutationnovelS177N0.33
LUADchr1782088826Missense_MutationNAM785I0.18
LUADchr1782090966SilentNAL532L0.48
LUADchr1782085264Missense_MutationnovelS1421C0.28
LUADchr1782079159Frame_Shift_DelnovelS2507Tfs*330.16
LUADchr1782089084Missense_Mutationrs770233064S730F0.45
LUADchr1782084264Missense_Mutationrs779327861P1630L0.45
LUADchr1782093721Missense_MutationNAV111L0.28
LUSCchr1782086348Missense_MutationNAP1213L0.31
LUSCchr1782082927Silentrs541901851S1918S0.23
LUSCchr1782080217Missense_MutationNAP2357S0.43
LUSCchr1782096453Splice_Sitenovel0.59
LUSCchr1782080842Missense_MutationnovelP2226S0.29
LUSCchr1782079597Silentrs199781548A2386A0.3
LUSCchr1782080913Missense_MutationnovelC2202Y0.35
LUSCchr1782095360SilentNAR80R0.55
LUSCchr1782089053SilentnovelV740V0.24
LUSCchr1782092569SilentnovelL305L0.13
LUSCchr1782083246Missense_MutationnovelR1841C0.23
LUSCchr1782088024Silentrs770009057S932S0.38
LUSCchr1782090477Missense_MutationnovelA590S0.38
LUSCchr1782096370Missense_MutationNAL26F0.17
LUSCchr1782083544Missense_MutationnovelF1772L0.1
LUSCchr1782090430Missense_MutationnovelW605C0.47
LUSCchr1782085298SilentnovelQ1409Q0.42
LUSCchr1782090943Missense_MutationnovelS540N0.13
OVchr1782083224Missense_MutationnovelH1848R0.09
OVchr1782095451Missense_MutationNAR50Q0.71
OVchr1782083252Missense_MutationNAA1839T0.83
PAADchr1782091332Missense_MutationnovelP461L0.15
PAADchr1782079518Missense_Mutationrs765469966R2413C0.19
PAADchr1782080821Missense_Mutationrs769486658R2233W0.18
PAADchr1782081170Missense_MutationnovelA2197T0.14
PAADchr1782082016SilentnovelG2052G0.21
PAADchr1782082027Missense_Mutationrs774467499R2049W0.2
PAADchr1782084635Missense_MutationNAS1549F0.14
PAADchr1782087227Missense_MutationnovelL1084M0.15
PAADchr1782087997Silentrs539431759S941S0.22
PAADchr1782089383Missense_MutationnovelA656V0.19
PAADchr1782092811Splice_Regionrs758785292G260G0.23
PRADchr1782088974Missense_MutationNAL767M0.39
PRADchr1782089153Frame_Shift_DelnovelP707Hfs*340.27
PRADchr1782083361Silentrs776117487E1802E0.42
PRADchr1782086348Missense_MutationnovelP1213H0.5
READchr1782087055Missense_MutationnovelC1141F0.18
READchr1782092544Missense_MutationnovelA314P0.35
READchr1782095454Missense_Mutationrs201186614R49Q0.24
READchr1782086413Silentrs758512736N1191N0.49
READchr1782081778Missense_Mutationrs141935205D2077N0.33
SARCchr1782084935Missense_MutationnovelN1476K0.17
SARCchr1782092780Missense_MutationnovelQ271K0.16
SARCchr1782095411Silentrs752312151S63S0.71
SARCchr1782084283Missense_MutationnovelT1624S0.47
SKCMchr1782082015Missense_Mutationrs770753805L2053F0.35
SKCMchr1782093705Missense_MutationNAT116I0.28
SKCMchr1782088025Missense_Mutationrs146356200S932F0.22
SKCMchr1782083234Nonsense_MutationNAQ1845*0.28
SKCMchr1782083560SilentNAF1766F0.43
SKCMchr1782088535SilentNAF816F0.46
SKCMchr1782080855Silentrs763962178S2221S0.14
SKCMchr1782093611SilentnovelF147F0.21
SKCMchr1782086349Missense_MutationNAP1213S0.24
SKCMchr1782087200Missense_Mutationrs778473340H1093Y0.18
SKCMchr1782089678Missense_MutationnovelP640L0.37
SKCMchr1782091014Silentrs145311183F516F0.26
SKCMchr1782088816Missense_MutationNAH789Y0.88
SKCMchr1782087793Missense_MutationnovelP979S0.57
SKCMchr1782087794SilentnovelN978N0.57
SKCMchr1782082021Missense_Mutationrs745655516E2051K0.09
SKCMchr1782080717SilentNAP2267P0.35
SKCMchr1782079499Missense_Mutationrs369341170A2419V0.31
SKCMchr1782087712Nonsense_MutationNAQ1006*0.27
SKCMchr1782087713SilentnovelF1005F0.33
SKCMchr1782091387Missense_Mutationrs761357571R443W0.38
SKCMchr1782080832Missense_MutationnovelP2229L0.24
SKCMchr1782080833Missense_MutationnovelP2229S0.23
SKCMchr1782089378Missense_MutationNAV658M0.54
SKCMchr1782083050SilentNAS1877S0.46
SKCMchr1782089380Missense_Mutationrs200575117P657L0.44
SKCMchr1782089381Missense_MutationnovelP657S0.43
SKCMchr1782085510Missense_MutationnovelP1365L0.45
SKCMchr1782081617Silentrs200241722A2130A0.85
SKCMchr1782089261Missense_MutationnovelE697K0.22
SKCMchr1782089262Silentrs372743066Q696Q0.23
SKCMchr1782090956Nonsense_MutationnovelQ536*0.12
SKCMchr1782088243Silentrs751139540F886F0.23
SKCMchr1782085245Missense_MutationNAS1427F0.28
SKCMchr1782082932Missense_MutationNAR1917C0.23
SKCMchr1782082927Silentrs541901851S1918S0.46
SKCMchr1782082928Missense_MutationnovelS1918F0.45
SKCMchr1782084603In_Frame_DelnovelH1553_G1560delinsR0.52
SKCMchr1782084570Missense_MutationnovelL1571F0.59
SKCMchr1782084571Silentrs753346824S1570S0.59
SKCMchr1782080811Missense_Mutationrs201913904S2236F0.43
SKCMchr1782086485SilentNAA1167A0.35
SKCMchr1782084635Missense_MutationNAS1549F0.28
SKCMchr1782084530Missense_MutationNAS1584F0.92
SKCMchr1782089642Missense_MutationnovelS652L0.83
SKCMchr1782095399SilentNAV67V0.39
STADchr1782086502Missense_MutationNAP1162S0.3
STADchr1782088445Silentrs370854247A846A0.32
STADchr1782085547Frame_Shift_DelNAL1353Sfs*200.43
STADchr1782083611Silentrs776715958A1749A0.38
STADchr1782091331Silentrs565811170P461P0.48
STADchr1782089376SilentnovelV658V0.08
STADchr1782086499Missense_Mutationrs201281021G1163R0.31
STADchr1782085288Frame_Shift_InsnovelI1413Hfs*220.18
STADchr1782091341Missense_Mutationrs143812680A458V0.29
STADchr1782088209Missense_MutationNAT898A0.25
STADchr1782080792Silentrs750578532R2242R0.1
STADchr1782091441Missense_Mutationrs781366271R425W0.5
STADchr1782081682Missense_MutationNAF2109L0.06
STADchr1782083312Missense_Mutationrs369955820R1819W0.19
STADchr1782088454Silentrs146170446D843D0.22
STADchr1782091050Silentrs747732644R504R0.28
STADchr1782088877Splice_SiteNAX769_splice0.11
STADchr1782082085SilentNAA2029A0.2
STADchr1782092519Missense_MutationnovelI322T0.4
STADchr1782087108SilentNAT1123T0.22
STADchr1782079513Missense_MutationNAQ2414H0.23
STADchr1782091341Missense_Mutationrs143812680A458V0.42
STADchr1782079157Missense_MutationNAV2508M0.25
STADchr1782087140Missense_Mutationrs201182683I1113V0.23
STADchr1782093630Missense_MutationNAA141V0.12
STADchr1782093667Missense_MutationnovelG129C0.14
STADchr1782096320Splice_Regionrs201369909A42A0.38
STADchr1782086487Missense_Mutationrs758283388A1167S0.23
STADchr1782081178Missense_MutationNAA2194V0.36
STADchr1782087813Missense_Mutationrs202024339P972L0.22
STADchr1782079378Silentrs781074972G2459G0.31
STADchr1782080198Missense_MutationNAA2363V0.18
THCAchr1782085359Missense_MutationNAV1389E0.21
UCECchr1782092795Frame_Shift_DelnovelD267Yfs*180.3
UCECchr1782087988Silentrs755643560F944F0.28
UCECchr1782081659Silentrs376473813A2116A0.44
UCECchr1782082554Silentrs199700916P1964P0.13
UCECchr1782087723Missense_MutationnovelG1002V0.16
UCECchr1782080764Missense_MutationnovelG2252S0.54
UCECchr1782083207Missense_MutationNAV1854L0.42
UCECchr1782093271Missense_MutationnovelL201F0.34
UCECchr1782087096SilentnovelC1127C0.21
UCECchr1782088291SilentNAS870S0.37
UCECchr1782081345Silentrs371569954R2138R0.29
UCECchr1782082548Silentrs763862356G1966G0.43
UCECchr1782089166Missense_Mutationrs768238548R703W0.32
UCECchr1782080799Missense_Mutationrs17848948S2240L0.4
UCECchr1782080769Missense_MutationnovelI2250T0.44
UCECchr1782081774Missense_Mutationrs765291298T2078M0.42
UCECchr1782084022Missense_MutationnovelA1684V0.48
UCECchr1782085335Missense_MutationnovelG1397D0.44
UCECchr1782087377SilentnovelI1057I0.31
UCECchr1782080379SilentNAA2346A0.13
UCECchr1782084549SilentNAL1578L0.18
UCECchr1782087080Missense_MutationNAA1133T0.27
UCECchr1782087995Missense_Mutationrs775022621R942H0.2
UCECchr1782088804SilentNAL793L0.3
UCECchr1782089367Silentrs375145013F661F0.19
UCECchr1782084587Missense_MutationnovelT1565M0.48
UCECchr1782080768Silentrs764886152I2250I0.16
UCECchr1782088391Splice_Regionrs757754186I864I0.2
UCECchr1782084648Missense_Mutationrs150970220R1545C0.38
UCECchr1782080151Nonsense_MutationnovelE2379*0.18
UCECchr1782083783Missense_MutationNAT1736M0.17
UCECchr1782088390Missense_Mutationrs199546508D865N0.16
UCECchr1782087423Missense_MutationnovelA1042V0.48
UCECchr1782081331Missense_MutationnovelV2143G0.53
UCECchr1782082099Missense_MutationnovelG2025R0.34
UCECchr1782092930Missense_Mutationrs759567154A249T0.66
UCECchr1782090971Missense_Mutationrs765536318G531S0.23
UCECchr1782096399Missense_MutationnovelS16L0.43
UCECchr1782087504Missense_MutationnovelG1015D0.31
UCECchr1782080542Missense_MutationnovelC2292S0.4
UCECchr1782080720Silentrs746255282I2266I0.42
UCECchr1782082674Silentrs768226050Y1924Y0.3
UCECchr1782083829Missense_MutationNAA1721T0.33
UCECchr1782087154Missense_Mutationrs779523230E1108G0.21
UCECchr1782089260Missense_MutationnovelE697G0.47
UCECchr1782090943Missense_MutationnovelS540N0.36
UCECchr1782085547Frame_Shift_DelNAL1353Sfs*200.31
UCECchr1782088981Silentrs762161225H764H0.18
UCECchr1782081660Missense_Mutationrs539833943A2116V0.44
UCECchr1782081230Missense_MutationnovelR2177C0.55
UCECchr1782089367Silentrs375145013F661F0.57
UCECchr1782092767Missense_Mutationrs140748143S275L0.41
UCECchr1782096450Splice_Regionnovel0.55
UCECchr1782087988Silentrs755643560F944F0.4
UCECchr1782081228SilentNAR2177R0.28
UCECchr1782096407SilentnovelL13L0.28
UCECchr1782080161Missense_MutationnovelF2375L0.42
UCECchr1782093607Missense_MutationnovelD149N0.31
UCECchr1782081279SilentnovelV2160V0.45
UCECchr1782084912Missense_Mutationrs547076440P1484L0.51
UCECchr1782088200Missense_Mutationrs768819928R901C0.53
UCECchr1782081165Splice_Regionrs772045989S2198S0.11
UCECchr1782091286Missense_MutationnovelE476D0.53
UCECchr1782079526Missense_Mutationrs373613096G2410D0.36
UCECchr1782088414Missense_Mutationrs747653984P857S0.41
UCECchr1782096362Silentrs775907097G28G0.42
UCECchr1782086292Missense_MutationNAV1232L0.25
UCECchr1782086293Silentrs139409322A1231A0.25
UCECchr1782089285Missense_MutationnovelA689T0.32
UCECchr1782088558Missense_Mutationrs766712508D809N0.26
UCECchr1782093600Missense_MutationnovelR151I0.45
UCECchr1782096364Missense_MutationnovelG28S0.4
UCECchr1782079248SilentnovelI2477I0.4
UCECchr1782080547SilentnovelI2290I0.4
UCECchr1782088391Splice_Regionrs757754186I864I0.35
UCECchr1782088781Silentrs747222387I800I0.54
UCECchr1782090907Missense_MutationnovelS552L0.42
UCECchr1782091564Missense_MutationnovelR384S0.23
UCECchr1782083638Splice_Regionrs202024354G1740G0.23
UCECchr1782093314Frame_Shift_DelnovelG187Afs*60.47
UCECchr1782089048Missense_MutationNAP742H0.17
UCECchr1782091559SilentnovelG385G0.31
UCECchr1782095465Silentrs767010365Y45Y0.31
UCECchr1782095340Missense_MutationnovelY87C0.44
UCECchr1782092720Missense_MutationnovelE291K0.5
UCECchr1782083071SilentnovelP1870P0.41
UCECchr1782084825Frame_Shift_InsnovelA1513Gfs*130.34
UCECchr1782089119SilentnovelP718P0.17
UCECchr1782096396Missense_MutationnovelE17G0.37
UCECchr1782081766Missense_MutationnovelS2081G0.18
UCECchr1782087703SilentnovelL1009L0.36
UCECchr1782079215SilentNAS2488S0.29
UCECchr1782082075Missense_MutationNAN2033D0.11
UCECchr1782084100Missense_Mutationrs569723911A1658V0.15
UCECchr1782079412Missense_MutationNAA2448V0.45
UCECchr1782085547Frame_Shift_DelNAL1353Sfs*200.49
UCECchr1782085547Frame_Shift_DelNAL1353Sfs*200.45
UCECchr1782093408Missense_Mutationrs763417026A156T0.45
UCECchr1782079472Missense_Mutationrs745397050R2428H0.5
UCECchr1782088826Missense_MutationNAM785I0.44
UCECchr1782085547Frame_Shift_DelNAL1353Sfs*200.34
UCECchr1782084707Missense_MutationnovelE1525G0.34
UCECchr1782081192Silentrs375789629E2189E0.38
UCECchr1782082385SilentnovelQ1983Q0.45
UCECchr1782083403Silentrs569811117N1788N0.36
UCECchr1782086367Missense_MutationnovelP1207S0.53
UCECchr1782087086Missense_Mutationrs769282070R1131C0.38
UCECchr1782079164Silentrs1140624R2505R0.37
UCECchr1782086466Missense_MutationnovelS1174T0.41
UCSchr1782091552Missense_MutationnovelV388M0.54
UCSchr1782091343SilentnovelI457I0.29
UCSchr1782082337SilentnovelT1999T0.23

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.18890.19593
BLCAAMP0.38730.00012456
CESCDEL0.10850.00067839
CHOLDEL00.048655
DLBCDEL0.02080.00048456
ESCADEL0.15220.00081373
KIRPAMP0.67010.14801
LGGAMP0.06821.52e-05
LUSCDEL0.11780.00018962
MESODEL0.05750.00015289
PAADDEL0.14670.169
READDEL0.12730.014135
SARCAMP0.20620.032181
SKCMAMP0.28347.0388e-08
THCADEL0.0020.221
THYMDEL0.01630.10563
UCSDEL0.14290.1218
UVMAMP0.16250.054583

Survival Analysis
CancerP-value Q-value
KIRC0.0001

Kaplan-Meier Survival Analysis

SARC0.00012

Kaplan-Meier Survival Analysis

MESO0.00026

Kaplan-Meier Survival Analysis

ACC0.0015

Kaplan-Meier Survival Analysis

LUSC0.0023

Kaplan-Meier Survival Analysis

KIRP0.0001

Kaplan-Meier Survival Analysis

PAAD0.035

Kaplan-Meier Survival Analysis

BLCA0.0076

Kaplan-Meier Survival Analysis

CESC0.00012

Kaplan-Meier Survival Analysis

READ0.02

Kaplan-Meier Survival Analysis

LAML0.048

Kaplan-Meier Survival Analysis

KICH0.016

Kaplan-Meier Survival Analysis

UCEC0.0063

Kaplan-Meier Survival Analysis

LIHC0.034

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

THCA0.024

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000169710 (Gene tree)
Gene ID
2194
Gene Symbol
FASN
Alias
FAS|SDR27X1
Full Name
fatty acid synthase
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
20,000 bases
Position
chr17:82,078,333-82,098,332
Accession
3594
RBP type
non-canonical RBP
Summary
The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
29585583-----
22444451Effect of level of eicosapentaenoic acid on the transcriptional regulation of delta-9 desaturase using a novel in vitro bovine intramuscular adipocyte cell culture model.Animal2009 MayWaters SMdoi: 10.1017/S1751731109004054.
30891825Arctigenin improves lipid metabolism by regulating AMP-activated protein kinase and downstream signaling pathways.J Cell Biochem2019 AugSong Ydoi: 10.1002/jcb.28602
15026365Dysregulation of sterol response element-binding proteins and downstream effectors in prostate cancer during progression to androgen independence.Cancer Res2004 Mar 15Ettinger SL-
19026012Phosphatase and tensin homolog (PTEN) regulates hepatic lipogenesis, microsomal triglyceride transfer protein, and the secretion of apolipoprotein B-containing lipoproteins.Hepatology2008 DecQiu Wdoi: 10.1002/hep.22565.
22469867Therapeutic effects of angiotensin II type 1 receptor blocker, irbesartan, on non-alcoholic steatohepatitis using FLS-ob/ob male mice.Int J Mol Med2012 JulKato Jdoi: 10.3892/ijmm.2012.958
26525371Bariatric surgery acutely changes the expression of inflammatory and lipogenic genes in obese adipose tissue.Surg Obes Relat Dis2016 FebOrtega FJdoi: 10.1016/j.soard.2015.08.498
31137884Cyanidin-3-O-galactoside-enriched Aronia melanocarpa extract attenuates weight gain and adipogenic pathways in high-fat diet-induced obese C57BL/6 mice.Nutrients2019 May 27Lim SMdoi: 10.3390/nu11051190.
31297058Emodin Induced SREBP1-Dependent and SREBP1-Independent Apoptosis in Hepatocellular Carcinoma Cells.Front Pharmacol2019 Jun 25Yang Ndoi: 10.3389/fphar.2019.00709
12600843Addition of inulin to a moderately high-carbohydrate diet reduces hepatic lipogenesis and plasma triacylglycerol concentrations in humans.Am J Clin Nutr2003 MarLetexier D-
23079976Conjugated linoleic acid-induced milk fat reduction associated with depressed expression of lipogenic genes in lactating Holstein mammary glands.Genet Mol Res2012 Sep 17Han LQdoi: 10.4238/2012.September.17.2.
22339699Effects of growth rate on carcass and meat quality traits and their association with metabolism-related gene expression in finishing pigs.Anim Sci J2012 FebYang Ydoi: 10.1111/j.1740-0929.2011.00929.x
21794016The effects of concentrations of lysine in media on differentiation of 3T3-L1 preadipocytes.Anim Sci J2011 AugKyoya Tdoi: 10.1111/j.1740-0929.2011.00882.x
25933497ChREBP binding and histone modifications modulate hepatic expression of the Fasn gene in a metabolic syndrome rat model.Nutrition2015 JunSuzuki Tdoi: 10.1016/j.nut.2015.01.005
29789508Dual Effects of Metformin on Adipogenic Differentiation of 3T3-L1 Preadipocyte in AMPK-Dependent and Independent Manners.Int J Mol Sci2018 May 23Chen Ddoi: 10.3390/ijms19061547.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000637693FASN-213100--- (aa)--
ENST00000635197FASN-207627-ENSP00000489514150 (aa)-A0A0U1RRG3
ENST00000580382FASN-204681-ENSP0000046294978 (aa)-J3KTF0
ENST00000637026FASN-211100-ENSP0000048980818 (aa)-A0A1B0GTR5
ENST00000636628FASN-209100-ENSP0000049092127 (aa)-A0A1B0GWG8
ENST00000636968FASN-210100-ENSP0000049055310 (aa)-A0A1B0GVK4
ENST00000634990FASN-2068407-ENSP000004889642509 (aa)-A0A0U1RQF0
ENST00000584610FASN-205857--- (aa)--
ENST00000637525FASN-212141--- (aa)--
ENST00000578424FASN-202951--- (aa)--
ENST00000306749FASN-2018565XM_011523538ENSP000003045922511 (aa)XP_011521840P49327
ENST00000635733FASN-208100--- (aa)--
ENST00000579410FASN-203424--- (aa)--
Gene Model
Click here to download ENSG00000169710's gene model file
Pathways
Pathway IDPathway NameSource
hsa00061Fatty acid biosynthesisKEGG
hsa01100Metabolic pathwaysKEGG
hsa01212Fatty acid metabolismKEGG
hsa04152AMPK signaling pathwayKEGG
hsa04910Insulin signaling pathwayKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000169710Emotions4E-627089181
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000169710rs2008971531782082645?Major depressive disorder27777418EFO_0003761
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000169710's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000169710FASN100100.000ENSMUSG00000025153Fasn96100.000Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001649osteoblast differentiation16210410.HDAProcess
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0004313[acyl-carrier-protein] S-acetyltransferase activity-IEAFunction
GO:0004314[acyl-carrier-protein] S-malonyltransferase activity-IEAFunction
GO:00043153-oxoacyl-[acyl-carrier-protein] synthase activity-IEAFunction
GO:00043163-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity-IEAFunction
GO:0004320oleoyl-[acyl-carrier-protein] hydrolase activity-IEAFunction
GO:0005515protein binding18022563.23427160.27478939.IPIFunction
GO:0005794Golgi apparatus-IDAComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0005886plasma membrane-IDAComponent
GO:0006084acetyl-CoA metabolic process-IEAProcess
GO:0006631fatty acid metabolic process7835891.TASProcess
GO:0006633fatty acid biosynthetic process-IEAProcess
GO:0008144drug binding-IEAFunction
GO:0008611ether lipid biosynthetic process-IEAProcess
GO:0008659(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity-IEAFunction
GO:0016020membrane16210410.19946888.HDAComponent
GO:0016295myristoyl-[acyl-carrier-protein] hydrolase activity-IEAFunction
GO:0016296palmitoyl-[acyl-carrier-protein] hydrolase activity-IEAFunction
GO:0030223neutrophil differentiation-IEAProcess
GO:0030224monocyte differentiation-IEAProcess
GO:0030879mammary gland development-IEAProcess
GO:0031177phosphopantetheine binding-IEAFunction
GO:0031325positive regulation of cellular metabolic process-TASProcess
GO:0042470melanosome-IEAComponent
GO:0042587glycogen granule-IEAComponent
GO:0042803protein homodimerization activity-IEAFunction
GO:0043170macromolecule metabolic process-IEAProcess
GO:0045296cadherin binding25468996.HDAFunction
GO:0045540regulation of cholesterol biosynthetic process-TASProcess
GO:0046949fatty-acyl-CoA biosynthetic process-TASProcess
GO:0047117enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity-IEAFunction
GO:00474513-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity-IEAFunction
GO:0055114oxidation-reduction process-IEAProcess
GO:0070062extracellular exosome19056867.20458337.23533145.HDAComponent
GO:0070402NADPH binding-IEAFunction
GO:0071353cellular response to interleukin-4-IEAProcess
GO:0090557establishment of endothelial intestinal barrier-IEAProcess
GO:01021313-oxo-glutaryl-[acp] methyl ester reductase activity-IEAFunction
GO:01021323-oxo-pimeloyl-[acp] methyl ester reductase activity-IEAFunction
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