EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
19242560Depletion of kinesin 5B affects lysosomal distribution and stability and induces peri-nuclear accumulation of autophagosomes in cancer cells.PLoS One2009Cardoso CMdoi: 10.1371/journal.pone.0004424
28911147KIF5B/RET Rearrangement in a Carcinoma of the Thyroid Gland: A Case Report of a Fatal Disease.J Clin Endocrinol Metab2017 Sep 1Viola Ddoi: 10.1210/jc.2017-00304.
30015159Oncogenic Function of a KIF5B-MET Fusion Variant in Non-Small Cell Lung Cancer.Neoplasia2018 AugGow CHdoi: 10.1016/j.neo.2018.06.007

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1032017261SilentnovelL881L0.28
BLCAchr10320559955'UTRnovel0.2
BLCAchr1032017237Frame_Shift_DelnovelR890Vfs*100.14
BLCAchr1032022947SilentNAV605V0.39
BLCAchr1032017290Missense_MutationnovelE872K0.16
BLCAchr1032055958Missense_MutationNAE6K0.5
BLCAchr10320560855'UTRnovel0.3
BLCAchr1032034738Missense_MutationnovelR355W0.09
BLCAchr1032023000Missense_MutationnovelT588A0.28
BLCAchr1032035618Missense_MutationnovelS289L0.32
BLCAchr1032035667Missense_MutationNAT273A0.25
BRCAchr1032037374Missense_MutationNAM197I0.11
BRCAchr1032033886Nonsense_MutationNAE422*0.23
BRCAchr1032022898Frame_Shift_DelNAM622Wfs*80.22
BRCAchr1032055958Missense_MutationNAE6K0.44
BRCAchr1032017149Nonsense_MutationNAQ919*0.11
BRCAchr1032048518In_Frame_DelnovelF52_Q53del0.24
BRCAchr1032035567Missense_MutationnovelS306L0.39
BRCAchr1032033970Nonsense_MutationnovelK394Lfs*30.08
BRCAchr1032028433Missense_MutationnovelV574L0.05
BRCAchr1032031239Missense_Mutationrs746242956A472V0.19
CESCchr1032018113Frame_Shift_DelnovelQ828Rfs*470.17
CESCchr1032037315Missense_MutationNAT217R0.32
CESCchr1032023025SilentNAG579G0.44
CESCchr1032019856Splice_SitenovelX769_splice0.41
CESCchr1032021122Missense_MutationnovelE702K0.13
CESCchr1032048515Missense_Mutationrs775994666S55R0.39
CESCchr1032021089Missense_MutationnovelQ713E0.06
CESCchr1032015551Missense_MutationnovelG957A0.3
CESCchr1032019902Missense_MutationNAL754F0.23
COADchr10320155233'UTRNA0.07
COADchr1032018102Missense_MutationnovelI832V0.16
COADchr10320559785'UTRnovel0.29
COADchr1032021240Missense_MutationnovelA694T0.06
COADchr1032017358Nonsense_MutationnovelL849*0.34
COADchr1032033880Nonsense_MutationnovelE424*0.18
COADchr1032018381Nonsense_MutationNAE792*0.29
COADchr1032035667Missense_MutationNAT273A0.3
COADchr1032028524Missense_MutationNAM543I0.43
COADchr1032017230Missense_Mutationrs773585260R892C0.36
COADchr1032022898Frame_Shift_DelNAM622Wfs*80.15
COADchr1032035961Missense_MutationnovelD249N0.18
COADchr1032037283Frame_Shift_DelnovelY228Sfs*30.11
COADchr1032033934Missense_Mutationrs377656602A406T0.25
COADchr1032031229Missense_MutationNAN475K0.21
COADchr1032017236Missense_Mutationrs760268366R890C0.27
COADchr1032015535Missense_MutationNAQ962H0.47
COADchr1032034832Missense_MutationNAK323N0.26
DLBCchr1032018382SilentnovelK791K0.21
ESCAchr1032035913Frame_Shift_DelnovelI265Ffs*180.44
ESCAchr1032023019SilentnovelG581G0.29
ESCAchr1032038179Missense_MutationnovelR161Q0.18
GBMchr1032017157Missense_Mutationrs200775134H916R0.48
GBMchr1032017203Missense_Mutationrs755716349R901C0.2
GBMchr1032055969Missense_Mutationrs763866357A2V0.14
HNSCchr1032032739SilentnovelE447E0.23
HNSCchr1032022240SilentnovelK644K0.08
HNSCchr1032037313Missense_MutationnovelQ218E0.07
HNSCchr1032015657Frame_Shift_InsnovelK922Lfs*580.11
HNSCchr1032040429Missense_Mutationrs147256984I81M0.24
KICHchr1032032766Missense_MutationnovelE438D0.05
KIRCchr1032018317Missense_MutationNAK813M0.35
KIRCchr1032031259Missense_MutationNAR465S0.15
KIRPchr1032031115SilentNAT513T0.29
LGGchr1032017308Nonsense_Mutationrs150818260R866*0.09
LGGchr1032031108Missense_MutationnovelY516N0.15
LUADchr1032033845Missense_MutationnovelK435N0.42
LUADchr1032048512Missense_MutationNAT56A0.21
LUADchr1032040418Missense_MutationNAG85E0.14
LUADchr1032018349SilentNAL802L0.11
LUADchr1032015590Missense_Mutationrs533600588G944V0.51
LUSCchr1032017178Missense_MutationnovelK909R0.2
LUSCchr1032017177SilentNAK909K0.19
LUSCchr1032031257Missense_MutationNAD466G0.1
LUSCchr1032034742Silentrs762848647I353I0.35
LUSCchr1032019857Splice_SitenovelX769_splice0.12
LUSCchr1032040430Missense_MutationnovelI81R0.27
LUSCchr1032021042Missense_MutationNAK728N0.62
LUSCchr1032028537Missense_MutationNAK539T0.2
LUSCchr1032034800Frame_Shift_InsnovelE334Gfs*120.34
LUSCchr1032032717Missense_MutationnovelD455Y0.22
LUSCchr1032017218Missense_MutationnovelQ896E0.15
LUSCchr1032033854SilentNAL432L0.07
OVchr1032021037Missense_MutationnovelI730T0.09
OVchr1032040449Missense_MutationNAE75K0.38
OVchr1032040435SilentnovelG79G0.19
PAADchr1032031248Missense_MutationnovelN469S0.14
PAADchr1032021078SilentnovelI716I0.03
READchr1032022858Missense_Mutationrs369345488R635H0.21
READchr1032017224Missense_Mutationrs141491660R894C0.3
READchr1032018381Nonsense_MutationNAE792*0.47
READchr1032021098Missense_MutationnovelE710K0.44
READchr1032022859Missense_MutationnovelR635C0.38
READchr1032034756Nonsense_MutationnovelE349*0.36
READchr1032035651Missense_MutationnovelR278Q0.37
READchr1032037574Missense_MutationnovelE178K0.44
READchr1032018545Missense_Mutationrs201506716R775Q0.4
SARCchr10320114373'UTRnovel0.71
SARCchr1032022250Missense_MutationnovelA641D0.1
SKCMchr1032035991Missense_MutationnovelS239G0.2
SKCMchr1032037606Missense_MutationnovelG167E0.45
SKCMchr1032037543Missense_MutationNAS188F0.41
SKCMchr1032038173Missense_MutationNAP163L0.41
SKCMchr1032021100Missense_MutationNAR709I0.05
SKCMchr1032031233Missense_MutationNAL474P0.2
SKCMchr1032021062Missense_MutationNAE722K0.41
SKCMchr1032022205Missense_MutationnovelK656R0.39
SKCMchr1032039394Missense_MutationNAP109L0.27
STADchr1032033935Silentrs772429092T405T0.33
STADchr1032022898Frame_Shift_DelNAM622Wfs*80.17
STADchr1032018545Missense_Mutationrs201506716R775Q0.16
STADchr1032017281Missense_MutationNAK875E0.31
STADchr1032022928Missense_MutationNAE612K0.4
STADchr1032038181Missense_MutationNAN160K0.22
STADchr1032023037Splice_Siters768804971X576_splice0.45
STADchr1032022897Frame_Shift_Insrs777526028M622Nfs*50.37
STADchr1032028509SilentNAK548K0.15
STADchr1032040453SilentNAV73V0.22
STADchr1032018317Frame_Shift_DelnovelK813Rfs*620.17
STADchr1032038789Missense_MutationNAD144G0.23
STADchr1032022868Missense_MutationnovelC632R0.26
STADchr1032017352Missense_Mutationrs200746362R851H0.11
STADchr1032034835SilentNAA322A0.17
STADchr1032035973Missense_MutationNAG245C0.15
TGCTchr1032034749Missense_MutationnovelN351S0.08
THYMchr1032040456Missense_MutationnovelD72E0.08
UCECchr1032021085Missense_MutationnovelK714T0.04
UCECchr1032028436Missense_MutationNAD573Y0.25
UCECchr1032028567Missense_MutationnovelT529N0.19
UCECchr1032055948Missense_MutationnovelI9T0.1
UCECchr1032031210Missense_MutationNAD482N0.32
UCECchr1032040436Missense_MutationNAG79E0.31
UCECchr1032019892Missense_Mutationrs761138140D758N0.11
UCECchr1032035652Nonsense_MutationNAR278*0.42
UCECchr1032031228Missense_MutationnovelR476C0.2
UCECchr1032033935Silentrs772429092T405T0.37
UCECchr1032017302Nonsense_MutationNAR868*0.48
UCECchr1032018357Missense_MutationNAR800C0.3
UCECchr1032018120Missense_MutationnovelA826T0.43
UCECchr1032039377Missense_MutationnovelI115L0.33
UCECchr1032034731Missense_MutationNAT357N0.17
UCECchr1032018546Nonsense_MutationNAR775*0.03
UCECchr1032022897Missense_MutationNAM622T0.45
UCECchr1032017202Missense_MutationNAR901H0.18
UCECchr1032031246Missense_MutationnovelM470V0.04
UCECchr1032031248Frame_Shift_InsnovelN469Rfs*110.05
UCECchr1032040428Missense_MutationNAF82V0.3
UCECchr1032017302Nonsense_MutationNAR868*0.37
UCECchr1032034815Missense_MutationNAV329A0.39
UCECchr1032019858Missense_Mutationrs200339436T769M0.37
UCECchr1032037277Missense_MutationnovelV230I0.09
UCECchr1032034793SilentnovelT336T0.26
UCECchr1032017202Missense_MutationNAR901H0.28
UCECchr1032031227Missense_MutationNAR476H0.41
UCECchr1032023012Missense_MutationnovelD584Y0.13
UCECchr1032032768Nonsense_MutationnovelE438*0.33
UCECchr1032031073Splice_Regionrs749487701S527S0.59
UCECchr1032022898Frame_Shift_DelNAM622Wfs*80.31
UCECchr10320112543'UTRnovel0.34
UCECchr1032021096Missense_MutationnovelE710D0.51
UCECchr1032034691Splice_RegionnovelN370N0.23
UCECchr10320114943'UTRnovel0.33
UCECchr1032022898Frame_Shift_DelNAM622Wfs*80.33
UCECchr1032017307Missense_MutationNAR866Q0.42
UCECchr1032035948Frame_Shift_DelnovelN253Tfs*300.31
UCECchr1032017236Missense_Mutationrs760268366R890C0.28
UCECchr1032018545Missense_Mutationrs201506716R775Q0.39
UCECchr1032019892Missense_Mutationrs761138140D758Y0.4
UCECchr1032022859Missense_MutationnovelR635C0.45
UCECchr1032019928Missense_Mutationrs756101109R746C0.37
UCECchr1032037336Missense_MutationnovelI210S0.37
UCECchr1032021039SilentnovelL729L0.2
UCECchr1032021040Missense_MutationnovelL729R0.13
UCECchr1032048487Missense_MutationnovelD64V0.11
UCECchr10320113803'UTRnovel0.3
UCECchr1032018537Missense_MutationNAA778T0.41
UCECchr1032037594Missense_Mutationrs551976993R171H0.54
UCECchr1032017248Nonsense_MutationNAE886*0.35
UCECchr1032033878SilentNAE424E0.33
UCECchr1032040440Missense_MutationNAN78H0.36
UCECchr10320115013'UTRnovel0.29
UCECchr1032033962SilentnovelI396I0.06
UCECchr1032035660Missense_MutationNAV275A0.32
UCECchr1032021102Silentrs757194853H708H0.09
UCECchr1032033873Missense_MutationnovelA426V0.23
UCECchr1032022898Frame_Shift_DelNAM622Wfs*80.37
UCECchr1032037363Missense_MutationnovelS201N0.38
UCECchr1032031173Missense_MutationNAA494D0.32
UCECchr1032015555Nonsense_Mutationrs201380973R956*0.44
UCECchr1032031112SilentnovelK514K0.24
UCSchr1032017203Missense_Mutationrs755716349R901C0.32

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.10.19593
BLCADEL0.14220.16614
STADAMP0.22220.021867

Survival Analysis
CancerP-value Q-value
THYM0.0091

Kaplan-Meier Survival Analysis

KIRC0.011

Kaplan-Meier Survival Analysis

SARC0.04

Kaplan-Meier Survival Analysis

MESO0.015

Kaplan-Meier Survival Analysis

ACC0.00028

Kaplan-Meier Survival Analysis

SKCM0.00079

Kaplan-Meier Survival Analysis

BRCA0.0074

Kaplan-Meier Survival Analysis

KICH0.04

Kaplan-Meier Survival Analysis

LIHC0.0036

Kaplan-Meier Survival Analysis

LGG0.0036

Kaplan-Meier Survival Analysis

UVM0.013

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000170759 (Gene tree)
Gene ID
3799
Gene Symbol
KIF5B
Alias
KNS|KNS1
Full Name
kinesin family member 5B
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
47,434 bases
Position
chr10:32,009,010-32,056,443
Accession
6324
RBP type
non-canonical RBP
Summary
(Kinesin Family Member 5B) is a Protein Coding gene. Diseases associated with KIF5B include Blackwater Fever and Pulmonary Large Cell Neuroendocrine Carcinoma. Among its related pathways are Circadian entrainment and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include ATPase activity and microtubule motor activity. An important paralog of this gene is KIF5C.
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
10523505The suppression of testis-brain RNA binding protein and kinesin heavy chain disrupts mRNA sorting in dendrites.J Cell Sci1999 NovSevert WL-
11884553Herpes simplex virus tegument protein US11 interacts with conventional kinesin heavy chain.J Virol2002 AprDiefenbach RJ-
28028052An RNA-binding atypical tropomyosin recruits kinesin-1 dynamically to oskar mRNPs.EMBO J2017 Feb 1Gaspar Idoi: 10.15252/embj.201696038
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000493889KIF5B-202494--- (aa)--
ENST00000302418KIF5B-2015877XM_017016224ENSP00000307078963 (aa)XP_016871713P33176
Gene Model
Click here to download ENSG00000170759's gene model file
Pathways
Pathway IDPathway NameSource
hsa04144EndocytosisKEGG
hsa04728Dopaminergic synapseKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000170759Waist-Hip Ratio5.5140000E-005-
ENSG00000170759Cryptorchidism9.5700000E-005-
ENSG00000170759Bipolar Disorder5E-623092984
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000170759rs17757151032020077GBipolar disorder with mood-incongruent psychosis23092984[NR]1.18EFO_0000289
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000170759's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003777microtubule motor activity21873635.IBAFunction
GO:0003777microtubule motor activity28426968.IDAFunction
GO:0003777microtubule motor activity-ISSFunction
GO:0005515protein binding19164528.20562859.21915095.25855459.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005815microtubule organizing center-IDAComponent
GO:0005829cytosol-IDAComponent
GO:0005871kinesin complex21873635.IBAComponent
GO:0005874microtubule21873635.IBAComponent
GO:0007018microtubule-based movement21873635.IBAProcess
GO:0007028cytoplasm organization-IEAProcess
GO:0008017microtubule binding21873635.IBAFunction
GO:0008017microtubule binding28426968.IDAFunction
GO:0008017microtubule binding-ISSFunction
GO:0008432JUN kinase binding-IEAFunction
GO:0016020membrane19946888.HDAComponent
GO:0016887ATPase activity21873635.IBAFunction
GO:0021766hippocampus development-IEAProcess
GO:0031340positive regulation of vesicle fusion-IEAProcess
GO:0031982vesicle20682791.IDAComponent
GO:0032230positive regulation of synaptic transmission, GABAergic-IEAProcess
GO:0035253ciliary rootlet-IEAComponent
GO:0035617stress granule disassembly-ISSProcess
GO:0035774positive regulation of insulin secretion involved in cellular response to glucose stimulus-IEAProcess
GO:0042391regulation of membrane potential19675065.IDAProcess
GO:0042802identical protein binding17013387.18004302.IPIFunction
GO:0043268positive regulation of potassium ion transport19675065.IDAProcess
GO:0044295axonal growth cone-IEAComponent
GO:0045296cadherin binding25468996.HDAFunction
GO:0045335phagocytic vesicle-IEAComponent
GO:0047496vesicle transport along microtubule28426968.IDAProcess
GO:0047496vesicle transport along microtubule-ISSProcess
GO:0048471perinuclear region of cytoplasm-ISSComponent
GO:0051642centrosome localization20386726.IMPProcess
GO:0071346cellular response to interferon-gamma-IEAProcess
GO:0072383plus-end-directed vesicle transport along microtubule-IEAProcess
GO:0090316positive regulation of intracellular protein transport-IEAProcess
GO:0099609microtubule lateral binding-IEAFunction
GO:0099641anterograde axonal protein transport-ISSProcess
GO:1903078positive regulation of protein localization to plasma membrane19675065.IDAProcess
GO:1904115axon cytoplasm-IEAComponent
GO:1905152positive regulation of voltage-gated sodium channel activity-IEAProcess
GO:1990048anterograde neuronal dense core vesicle transport-ISSProcess
GO:1990049retrograde neuronal dense core vesicle transport-ISSProcess
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us