EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26470845	Tumor suppressor ASXL1 is essential for the activation of INK4B expression in response to oncogene activity and anti-proliferative signals.	Cell Res	2015 Nov	Wu X	doi: 10.1038/cr.2015.121
27640403	ASXL1 and JAK2V617F gene mutation screening in Iranian patients with chronic myeloid leukemia.	Asia Pac J Clin Oncol	2017 Apr	Valikhani A	doi: 10.1111/ajco.12588
29556021	A novel ASXL1-OGT axis plays roles in H3K4 methylation and tumor suppression in myeloid malignancies.	Leukemia	2018 Jun	Inoue D	doi: 10.1038/s41375-018-0083-3

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr20	32435899	Nonsense_Mutation	NA	Q1063*	0.1
BLCA	chr20	32436394	Missense_Mutation	novel	E1228Q	0.29
BLCA	chr20	32436741	Missense_Mutation	novel	N1343K	0.32
BLCA	chr20	32434474	Nonsense_Mutation	NA	Q588*	0.14
BLCA	chr20	32433869	Silent	rs372630902	T557T	0.15
BLCA	chr20	32433888	Nonsense_Mutation	NA	K564*	0.36
BLCA	chr20	32434485	Nonsense_Mutation	rs371369583	Y591*	0.48
BLCA	chr20	32431405	Missense_Mutation	novel	I268S	0.4
BLCA	chr20	32435050	Nonsense_Mutation	rs751021760	Q780*	0.17
BLCA	chr20	32436975	Silent	novel	L1421L	0.15
BLCA	chr20	32431647	Missense_Mutation	novel	A316V	0.17
BLCA	chr20	32433430	Missense_Mutation	novel	R411L	0.14
BLCA	chr20	32433828	Missense_Mutation	NA	D544N	0.06
BLCA	chr20	32436218	Missense_Mutation	novel	S1169Y	0.49
BLCA	chr20	32433732	Nonsense_Mutation	rs757832294	Q512*	0.17
BLCA	chr20	32435981	Missense_Mutation	NA	R1090T	0.22
BLCA	chr20	32437254	Silent	rs751943497	I1514I	0.08
BLCA	chr20	32430008	Nonsense_Mutation	NA	Q225*	0.57
BLCA	chr20	32436547	Missense_Mutation	NA	V1279M	0.58
BLCA	chr20	32436518	Missense_Mutation	rs747065583	S1269L	0.23
BLCA	chr20	32435653	Missense_Mutation	novel	E981Q	0.07
BLCA	chr20	32437288	Missense_Mutation	novel	D1526N	0.05
BLCA	chr20	32436106	Missense_Mutation	novel	E1132K	0.28
BLCA	chr20	32433454	Missense_Mutation	NA	R419K	0.09
BLCA	chr20	32433529	Nonsense_Mutation	rs373126831	S444*	0.31
BLCA	chr20	32434442	Nonsense_Mutation	NA	S577*	0.16
BLCA	chr20	32435896	Missense_Mutation	rs776213974	P1062S	0.37
BLCA	chr20	32428378	Nonsense_Mutation	NA	R143*	0.08
BLCA	chr20	32369039	Silent	NA	L56L	0.44
BLCA	chr20	32436996	Silent	novel	S1428S	0.04
BRCA	chr20	32369050	Missense_Mutation	novel	L60P	0.34
BRCA	chr20	32436720	Silent	NA	G1336G	0.3
BRCA	chr20	32434780	Missense_Mutation	novel	D690H	0.14
BRCA	chr20	32435299	Missense_Mutation	NA	D863H	0.13
BRCA	chr20	32435728	Missense_Mutation	NA	E1006K	0.14
BRCA	chr20	32436094	Missense_Mutation	novel	D1128Y	0.1
BRCA	chr20	32436305	Missense_Mutation	NA	G1198V	0.12
BRCA	chr20	32433809	Missense_Mutation	NA	E537D	0.23
BRCA	chr20	32434736	Missense_Mutation	novel	P675L	0.7
BRCA	chr20	32436704	Missense_Mutation	novel	P1331Q	0.13
BRCA	chr20	32435759	Missense_Mutation	NA	A1016V	0.33
BRCA	chr20	32436269	Missense_Mutation	NA	T1186I	0.28
BRCA	chr20	32433418	Missense_Mutation	NA	H407R	0.17
BRCA	chr20	32433732	Nonsense_Mutation	rs757832294	Q512*	0.14
BRCA	chr20	32366450	Missense_Mutation	NA	G42R	0.33	HARE-HTH
BRCA	chr20	32435421	Silent	NA	S903S	0.42
BRCA	chr20	32436576	Silent	NA	G1288G	0.23
BRCA	chr20	32435949	Silent	NA	S1079S	0.33
BRCA	chr20	32433518	Silent	NA	K440K	0.19
BRCA	chr20	32434850	Missense_Mutation	novel	M713K	0.08
BRCA	chr20	32431365	Frame_Shift_Del	novel	*G256Ffs10**	0.2
BRCA	chr20	32434887	Silent	NA	R725R	0.2
CESC	chr20	32434639	Frame_Shift_Del	rs781077343	*G645Vfs58**	0.46
CESC	chr20	32437395	3'UTR	novel		0.25
CESC	chr20	32431648	Silent	rs569122152	A316A	0.41
CESC	chr20	32434639	Frame_Shift_Del	rs781077343	*G645Vfs58**	0.31
CESC	chr20	32437716	3'UTR	novel		0.31
CESC	chr20	32433500	Silent	novel	G434G	0.1
CESC	chr20	32435515	Missense_Mutation	novel	P935A	0.15
CESC	chr20	32430050	Missense_Mutation	novel	T239S	0.17
CESC	chr20	32430051	Missense_Mutation	novel	T239I	0.18
CESC	chr20	32372294	Intron	novel		0.21
CESC	chr20	32433808	Frame_Shift_Del	novel	*K538Rfs165**	0.39
CESC	chr20	32436810	Silent	rs143041800	S1366S	0.23
CESC	chr20	32435324	Nonsense_Mutation	NA	S871*	0.24
CESC	chr20	32434638	Frame_Shift_Ins	rs756958159	*G646Wfs12**	0.32
CESC	chr20	32436703	Missense_Mutation	NA	P1331S	0.45
COAD	chr20	32434547	Missense_Mutation	NA	R612M	0.2
COAD	chr20	32366450	Nonsense_Mutation	NA	G42*	0.31	HARE-HTH
COAD	chr20	32435242	Frame_Shift_Ins	rs750170870	*S846Qfs5**	0.29
COAD	chr20	32433917	Splice_Region	NA	R573R	0.16
COAD	chr20	32429956	Silent	novel	S207S	0.57
COAD	chr20	32435605	Nonsense_Mutation	rs397515401	R965*	0.4
COAD	chr20	32436858	Silent	rs375308689	A1382A	0.26
COAD	chr20	32433433	Missense_Mutation	rs201016007	S412F	0.38
COAD	chr20	32433906	Missense_Mutation	novel	P570T	0.26
COAD	chr20	32437232	Missense_Mutation	rs375101983	A1507V	0.14
COAD	chr20	32433807	Missense_Mutation	rs369425922	E537K	0.23
COAD	chr20	32435242	Frame_Shift_Ins	rs750170870	*S846Qfs5**	0.37
COAD	chr20	32434639	Frame_Shift_Del	rs781077343	*G645Vfs58**	0.53
COAD	chr20	32429954	Missense_Mutation	novel	S207G	0.18
COAD	chr20	32436701	Missense_Mutation	novel	P1330H	0.45
COAD	chr20	32434822	Frame_Shift_Del	rs778670589	*E705Sfs20**	0.46
COAD	chr20	32435165	Missense_Mutation	novel	V818A	0.16
COAD	chr20	32433896	Silent	NA	E566E	0.15
COAD	chr20	32436834	Frame_Shift_Del	novel	*G1376Vfs74**	0.09
COAD	chr20	32431396	Missense_Mutation	rs144349534	R265H	0.31
COAD	chr20	32434457	Missense_Mutation	novel	P582H	0.06
COAD	chr20	32437040	Missense_Mutation	NA	K1443R	0.1
COAD	chr20	32433554	Silent	NA	G452G	0.22
COAD	chr20	32434639	Frame_Shift_Del	rs781077343	*G645Vfs58**	0.17
COAD	chr20	32435242	Frame_Shift_Ins	rs750170870	*S846Qfs5**	0.26
COAD	chr20	32436306	Silent	novel	G1198G	0.26
COAD	chr20	32435386	Missense_Mutation	NA	S892A	0.38
COAD	chr20	32437447	3'UTR	novel		0.22
COAD	chr20	32434486	Nonsense_Mutation	NA	Q592*	0.29
COAD	chr20	32436394	Nonsense_Mutation	NA	E1228*	0.36
COAD	chr20	32428346	Missense_Mutation	rs370054224	S132L	0.07
COAD	chr20	32366463	Missense_Mutation	novel	M46T	0.06	HARE-HTH
COAD	chr20	32433698	Silent	NA	A500A	0.26
COAD	chr20	32433573	Missense_Mutation	NA	A459T	0.22
COAD	chr20	32434639	Frame_Shift_Del	rs781077343	*G645Vfs58**	0.29
DLBC	chr20	32435833	Frame_Shift_Del	novel	*A1041Pfs6**	0.34
ESCA	chr20	32366412	Missense_Mutation	novel	M29T	0.45	HARE-HTH
ESCA	chr20	32434639	Frame_Shift_Del	rs781077343	*G645Vfs58**	0.41
ESCA	chr20	32436535	Missense_Mutation	novel	S1275P	0.22
ESCA	chr20	32438568	3'UTR	novel		0.37
ESCA	chr20	32434447	Missense_Mutation	novel	I579F	0.14
ESCA	chr20	32434789	Nonsense_Mutation	rs373221034	R693*	0.41
ESCA	chr20	32431605	Missense_Mutation	novel	R302L	0.44
ESCA	chr20	32436589	Missense_Mutation	novel	D1293N	0.14
ESCA	chr20	32369116	Missense_Mutation	rs769697612	T82M	0.08
ESCA	chr20	32372329	Intron	novel		0.24
ESCA	chr20	32433620	Silent	rs753459688	P474P	0.5
ESCA	chr20	32429984	Missense_Mutation	novel	I217V	0.15
GBM	chr20	32434542	Silent	rs199829982	G610G	0.36
GBM	chr20	32431402	Missense_Mutation	novel	L267P	0.14
GBM	chr20	32434543	Missense_Mutation	rs372418554	A611T	0.35
GBM	chr20	32433720	Missense_Mutation	novel	P508T	0.3
GBM	chr20	32434542	Silent	rs199829982	G610G	0.27
GBM	chr20	32436331	Missense_Mutation	novel	V1207I	0.11
GBM	chr20	32435681	Missense_Mutation	novel	E990G	0.68
GBM	chr20	32429905	Missense_Mutation	novel	F190L	0.12
GBM	chr20	32435196	Silent	NA	G828G	0.21
GBM	chr20	32435864	Missense_Mutation	rs771896604	R1051H	0.27
GBM	chr20	32437157	Missense_Mutation	rs779918659	A1482V	0.16
GBM	chr20	32429414	Missense_Mutation	novel	H183R	0.39
GBM	chr20	32434542	Silent	rs199829982	G610G	0.32
HNSC	chr20	32436883	Missense_Mutation	novel	S1391C	0.19
HNSC	chr20	32435375	Missense_Mutation	novel	K888R	0.18
HNSC	chr20	32436180	Frame_Shift_Del	novel	*N1158Tfs13**	0.24
HNSC	chr20	32434789	Nonsense_Mutation	rs373221034	R693*	0.19
HNSC	chr20	32434789	Nonsense_Mutation	rs373221034	R693*	0.32
HNSC	chr20	32435728	Nonsense_Mutation	novel	E1006*	0.38
HNSC	chr20	32433893	Frame_Shift_Del	novel	*E566Sfs137**	0.2
HNSC	chr20	32434542	Silent	rs199829982	G610G	0.22
HNSC	chr20	32433813	Frame_Shift_Del	novel	*K539Sfs164**	0.35
HNSC	chr20	32431651	Silent	novel	A317A	0.28
HNSC	chr20	32433636	Missense_Mutation	rs545224250	E480K	0.07
HNSC	chr20	32366390	Missense_Mutation	novel	E22K	0.1	HARE-HTH
HNSC	chr20	32433581	Silent	novel	L461L	0.14
HNSC	chr20	32434586	Missense_Mutation	rs199602042	R625Q	0.16
HNSC	chr20	32433831	Frame_Shift_Del	NA	*R545Vfs158**	0.32
HNSC	chr20	32434491	Frame_Shift_Del	novel	*C594Afs109**	0.12
HNSC	chr20	32435479	Missense_Mutation	novel	E923Q	0.05
KIRC	chr20	32437334	Missense_Mutation	NA	R1541T	0.13
KIRC	chr20	32428147	Missense_Mutation	NA	S91C	0.44
KIRC	chr20	32435701	Nonsense_Mutation	NA	E997*	0.25
KIRP	chr20	32428183	Missense_Mutation	NA	E103G	0.12
LAML	chr20	32428422	Missense_Mutation	novel	Q157H	0.07
LAML	chr20	32434909	Nonsense_Mutation	rs387907078	Q733*	0.37
LAML	chr20	32434924	Frame_Shift_Del	NA	*G738Dfs6**	0.43
LAML	chr20	32435468	Frame_Shift_Ins	NA	*S921Tfs4**	0.48
LAML	chr20	32434431	Splice_Site	novel	X574_splice	0.35
LGG	chr20	32434598	Frame_Shift_Del	novel	*G629Afs5**	0.53
LGG	chr20	32366456	Missense_Mutation	novel	K44Q	0.4	HARE-HTH
LGG	chr20	32429908	Silent	rs753416045	S191S	0.41
LGG	chr20	32435176	Missense_Mutation	novel	T822A	0.37
LIHC	chr20	32433894	Nonsense_Mutation	novel	E566*	0.36
LIHC	chr20	32434875	Silent	novel	L721L	0.05
LIHC	chr20	32428422	Splice_Region	novel	Q157Q	0.08
LIHC	chr20	32436220	Silent	novel	L1170L	0.46
LIHC	chr20	32435756	Frame_Shift_Del	novel	A1016*	0.42
LIHC	chr20	32435819	Missense_Mutation	rs757758145	N1036S	0.45
LIHC	chr20	32434939	Frame_Shift_Del	novel	*G744Pfs26**	0.15
LUAD	chr20	32436202	Nonsense_Mutation	novel	G1164*	0.17
LUAD	chr20	32436394	Missense_Mutation	novel	E1228K	0.15
LUAD	chr20	32434882	Silent	NA	L724L	0.14
LUAD	chr20	32436145	Missense_Mutation	novel	G1145C	0.19
LUAD	chr20	32433499	Missense_Mutation	novel	G434V	0.22
LUAD	chr20	32433828	Missense_Mutation	novel	D544H	0.08
LUAD	chr20	32433832	Missense_Mutation	NA	R545P	0.39
LUAD	chr20	32434637	Frame_Shift_Ins	novel	*G643Rfs15**	0.29
LUAD	chr20	32431648	Silent	rs569122152	A316A	0.08
LUAD	chr20	32434942	Nonsense_Mutation	novel	G744*	0.17
LUAD	chr20	32437026	Missense_Mutation	NA	Q1438H	0.13
LUAD	chr20	32434661	Missense_Mutation	NA	G650D	0.44
LUAD	chr20	32436973	Missense_Mutation	NA	L1421F	0.26
LUAD	chr20	32434806	Silent	NA	P698P	0.31
LUAD	chr20	32429908	Silent	novel	S191S	0.19
LUAD	chr20	32435606	Missense_Mutation	novel	R965P	0.29
LUAD	chr20	32437114	Missense_Mutation	novel	A1468S	0.1
LUAD	chr20	32433626	Silent	novel	L476L	0.17
LUAD	chr20	32433484	Missense_Mutation	novel	E429G	0.45
LUSC	chr20	32369100	Missense_Mutation	novel	R77G	0.3
LUSC	chr20	32434747	Nonsense_Mutation	NA	G679*	0.23
LUSC	chr20	32436811	Missense_Mutation	rs147456014	V1367I	0.23
LUSC	chr20	32435517	Silent	novel	P935P	0.26
LUSC	chr20	32435995	Missense_Mutation	novel	S1095P	0.3
LUSC	chr20	32434920	Silent	NA	T736T	0.18
LUSC	chr20	32433307	Nonsense_Mutation	novel	S370*	0.12
LUSC	chr20	32434529	Missense_Mutation	novel	R606L	0.09
LUSC	chr20	32434530	Silent	novel	R606R	0.09
LUSC	chr20	32434973	Missense_Mutation	novel	T754I	0.15
LUSC	chr20	32434954	Missense_Mutation	novel	Q748E	0.37
LUSC	chr20	32435136	Silent	novel	P808P	0.16
LUSC	chr20	32433520	Missense_Mutation	rs751518063	S441F	0.41
LUSC	chr20	32436062	Missense_Mutation	NA	P1117L	0.34
LUSC	chr20	32436063	Silent	NA	P1117P	0.33
LUSC	chr20	32429432	Splice_Site	NA	X189_splice	0.2
LUSC	chr20	32436646	Missense_Mutation	NA	A1312S	0.27
LUSC	chr20	32369031	Missense_Mutation	NA	A54S	0.16	HARE-HTH
LUSC	chr20	32436055	Missense_Mutation	NA	S1115G	0.18
LUSC	chr20	32434638	Frame_Shift_Ins	rs756958159	*G646Wfs12**	0.35
LUSC	chr20	32429921	Missense_Mutation	novel	D196N	0.33
LUSC	chr20	32434547	Frame_Shift_Del	novel	*T613Pfs90**	0.51
LUSC	chr20	32433916	Missense_Mutation	novel	R573P	0.41
LUSC	chr20	32433843	Missense_Mutation	NA	R549C	0.35
LUSC	chr20	32431460	Silent	NA	F286F	0.24
LUSC	chr20	32434783	Silent	NA	L691L	0.1
LUSC	chr20	32433524	Silent	novel	V442V	0.2
LUSC	chr20	32435647	Missense_Mutation	novel	D979H	0.24
MESO	chr20	32436969	Silent	novel	K1419K	0.52
MESO	chr20	32437002	Silent	rs745543812	L1430L	0.33
OV	chr20	32436628	Nonsense_Mutation	novel	*G1306Efs8**	0.05
OV	chr20	32435630	Frame_Shift_Ins	novel	*Y974Lfs8**	0.46
OV	chr20	32437029	Silent	novel	A1439A	0.06
OV	chr20	32436680	Missense_Mutation	novel	M1323R	0.1
OV	chr20	32437280	Missense_Mutation	novel	C1523F	0.12
OV	chr20	32433345	Nonsense_Mutation	novel	K383*	0.1
OV	chr20	32435380	Frame_Shift_Del	novel	*L890Sfs18**	0.25
OV	chr20	32435382	In_Frame_Del	novel	V891_W898del	0.2
OV	chr20	32436680	Missense_Mutation	novel	M1323R	0.07
OV	chr20	32435466	Silent	rs529527086	H918H	0.25
OV	chr20	32436073	Missense_Mutation	novel	V1121L	0.04
OV	chr20	32429421	Silent	NA	E185E	0.5
OV	chr20	32369114	Silent	NA	F81F	0.14
PAAD	chr20	32433759	Missense_Mutation	novel	D521N	0.18
PAAD	chr20	32436608	Missense_Mutation	NA	G1299D	0.16
PRAD	chr20	32435925	Silent	rs756414158	A1071A	0.28
PRAD	chr20	32434542	Silent	rs199829982	G610G	0.45
PRAD	chr20	32433429	Missense_Mutation	rs148964601	R411C	0.51
PRAD	chr20	32434806	Silent	rs762926090	P698P	0.59
PRAD	chr20	32437270	Missense_Mutation	novel	G1520S	0.43
READ	chr20	32435959	Missense_Mutation	novel	A1083S	0.32
READ	chr20	32435907	Nonsense_Mutation	NA	W1065*	0.22
READ	chr20	32431661	Missense_Mutation	NA	R321W	0.39
READ	chr20	32436011	Nonsense_Mutation	NA	S1100*	0.18
READ	chr20	32432962	Missense_Mutation	NA	F354L	0.12
READ	chr20	32435812	Missense_Mutation	NA	K1034E	0.2
READ	chr20	32428347	Silent	NA	S132S	0.41
READ	chr20	32437344	3'UTR	novel		0.36
READ	chr20	32437107	Silent	novel	K1465K	0.4
SARC	chr20	32434543	Missense_Mutation	rs372418554	A611T	0.27
SARC	chr20	32431668	Missense_Mutation	novel	R323L	0.36
SKCM	chr20	32436577	Missense_Mutation	rs201302084	R1289W	0.22
SKCM	chr20	32433898	Missense_Mutation	NA	P567L	0.31
SKCM	chr20	32436743	Missense_Mutation	NA	S1344F	0.13
SKCM	chr20	32434882	Silent	NA	L724L	0.17
SKCM	chr20	32436023	Missense_Mutation	novel	T1104I	0.07
SKCM	chr20	32436234	Silent	rs747485168	K1174K	0.43
SKCM	chr20	32436235	Missense_Mutation	novel	E1175K	0.44
SKCM	chr20	32436744	Silent	NA	S1344S	0.3
SKCM	chr20	32436887	Missense_Mutation	NA	P1392L	0.46
SKCM	chr20	32433775	Missense_Mutation	novel	S526F	0.13
SKCM	chr20	32433776	Silent	NA	S526S	0.13
SKCM	chr20	32436111	Silent	NA	S1133S	0.07
SKCM	chr20	32436713	Missense_Mutation	NA	P1334L	0.39
SKCM	chr20	32428346	Missense_Mutation	rs370054224	S132L	0.31
SKCM	chr20	32428384	Missense_Mutation	rs769594900	L145F	0.65
SKCM	chr20	32436858	Silent	rs375308689	A1382A	0.31
SKCM	chr20	32429943	Missense_Mutation	NA	S203F	0.25
SKCM	chr20	32435930	Missense_Mutation	NA	R1073L	0.53
SKCM	chr20	32435230	Missense_Mutation	NA	P840S	0.14
SKCM	chr20	32436529	Missense_Mutation	rs587778060	R1273C	0.54
SKCM	chr20	32429898	Splice_Region	novel		0.45
SKCM	chr20	32436555	Silent	NA	S1281S	0.39
SKCM	chr20	32435585	Missense_Mutation	rs763638795	S958L	0.59
STAD	chr20	32435722	Missense_Mutation	NA	D1004N	0.26
STAD	chr20	32435196	Silent	NA	G828G	0.28
STAD	chr20	32431479	Missense_Mutation	novel	R293G	0.29
STAD	chr20	32435131	Missense_Mutation	rs138624526	V807I	0.36
STAD	chr20	32435915	Missense_Mutation	rs752058283	R1068Q	0.36
STAD	chr20	32435410	Missense_Mutation	NA	P900S	0.25
STAD	chr20	32429954	Missense_Mutation	novel	S207G	0.25
STAD	chr20	32428150	Missense_Mutation	rs745960978	R92H	0.41
STAD	chr20	32429378	Frame_Shift_Del	novel	*V172Cfs81**	0.32
STAD	chr20	32434639	Frame_Shift_Del	rs781077343	*G645Vfs58**	0.36
STAD	chr20	32429956	Silent	novel	S207S	0.22
STAD	chr20	32433832	Missense_Mutation	rs149449801	R545H	0.42
STAD	chr20	32369093	Silent	NA	L74L	0.25
STAD	chr20	32431395	Missense_Mutation	novel	R265C	0.07
STAD	chr20	32437111	Missense_Mutation	NA	L1467I	0.08
STAD	chr20	32434639	Frame_Shift_Del	rs781077343	*G645Vfs58**	0.39
STAD	chr20	32436623	Frame_Shift_Del	novel	*F1305Lfs145**	0.35
STAD	chr20	32435094	Silent	NA	T794T	0.15
STAD	chr20	32435416	Missense_Mutation	NA	P902S	0.16
STAD	chr20	32436954	Silent	NA	P1414P	0.2
STAD	chr20	32434639	Frame_Shift_Del	rs781077343	*G645Vfs58**	0.22
STAD	chr20	32435313	Silent	novel	G867G	0.19
STAD	chr20	32431604	Missense_Mutation	NA	R302C	0.36
STAD	chr20	32429350	Missense_Mutation	NA	K162E	0.18
STAD	chr20	32433844	Missense_Mutation	NA	R549H	0.21
STAD	chr20	32434571	Missense_Mutation	rs750708574	R620H	0.08
STAD	chr20	32435299	Frame_Shift_Ins	novel	C872*	0.23
STAD	chr20	32433908	Silent	rs769545573	P570P	0.32
STAD	chr20	32436831	Silent	rs746664804	F1373F	0.24
STAD	chr20	32433474	Frame_Shift_Del	novel	*K427Nfs35**	0.1
STAD	chr20	32433650	Missense_Mutation	NA	E484D	0.16
STAD	chr20	32434592	Missense_Mutation	NA	A627V	0.39
STAD	chr20	32437030	Frame_Shift_Del	novel	*Y1441Mfs9**	0.2
STAD	chr20	32369037	Missense_Mutation	NA	L56I	0.13
STAD	chr20	32434515	Silent	rs747758035	T601T	0.19
TGCT	chr20	32429913	Missense_Mutation	novel	C193Y	0.09
THCA	chr20	32436608	Missense_Mutation	NA	G1299D	0.32
THCA	chr20	32434938	Silent	NA	G742G	0.39
THYM	chr20	32434639	Frame_Shift_Del	rs781077343	*G645Vfs58**	0.16
UCEC	chr20	32429338	Missense_Mutation	NA	A158T	0.34
UCEC	chr20	32435304	Silent	rs147278940	D864D	0.24
UCEC	chr20	32436338	Missense_Mutation	NA	S1209N	0.37
UCEC	chr20	32429999	Missense_Mutation	rs780662350	E222K	0.38
UCEC	chr20	32433621	Missense_Mutation	rs754658635	D475N	0.32
UCEC	chr20	32435305	Missense_Mutation	rs147895689	E865K	0.31
UCEC	chr20	32437356	3'UTR	novel		0.24
UCEC	chr20	32433807	Missense_Mutation	rs369425922	E537K	0.24
UCEC	chr20	32434548	Missense_Mutation	novel	R612S	0.35
UCEC	chr20	32436678	Silent	rs147326327	P1322P	0.23
UCEC	chr20	32438354	3'UTR	rs574597562		0.18
UCEC	chr20	32434527	Silent	novel	C605C	0.38
UCEC	chr20	32438357	3'UTR	novel		0.31
UCEC	chr20	32369034	Missense_Mutation	NA	C55S	0.31
UCEC	chr20	32434537	Missense_Mutation	novel	T609A	0.36
UCEC	chr20	32435616	Silent	novel	S968S	0.46
UCEC	chr20	32436796	Missense_Mutation	novel	A1362T	0.4
UCEC	chr20	32437220	Missense_Mutation	novel	S1503L	0.47
UCEC	chr20	32437483	3'UTR	novel		0.48
UCEC	chr20	32429354	Missense_Mutation	NA	K163T	0.44
UCEC	chr20	32434725	Silent	novel	A671A	0.43
UCEC	chr20	32432962	Missense_Mutation	NA	F354L	0.39
UCEC	chr20	32435396	Missense_Mutation	novel	S895Y	0.45
UCEC	chr20	32433527	Silent	novel	A443A	0.28
UCEC	chr20	32435742	Silent	rs771376850	T1010T	0.23
UCEC	chr20	32438516	3'UTR	novel		0.57
UCEC	chr20	32434639	Frame_Shift_Del	rs781077343	*G645Vfs58**	0.51
UCEC	chr20	32428234	Missense_Mutation	NA	S120N	0.25
UCEC	chr20	32434789	Nonsense_Mutation	rs373221034	R693*	0.3
UCEC	chr20	32428378	Nonsense_Mutation	NA	R143*	0.14
UCEC	chr20	32435061	Silent	rs566661925	P783P	0.07
UCEC	chr20	32436451	Missense_Mutation	rs146747814	R1247C	0.24
UCEC	chr20	32436173	Missense_Mutation	novel	G1154D	0.18
UCEC	chr20	32435924	Missense_Mutation	rs531415735	A1071V	0.23
UCEC	chr20	32431406	Silent	NA	I268I	0.41
UCEC	chr20	32429920	Silent	rs557596857	A195A	0.62
UCEC	chr20	32437123	Missense_Mutation	rs779516123	V1471M	0.45
UCEC	chr20	32434588	Frame_Shift_Del	NA	*G626Vfs74**	0.54
UCEC	chr20	32436318	Missense_Mutation	novel	K1202N	0.25
UCEC	chr20	32431633	Frame_Shift_Ins	novel	*T314Yfs13**	0.29
UCEC	chr20	32436171	Silent	novel	H1153H	0.25
UCEC	chr20	32438603	3'UTR	novel		0.4
UCEC	chr20	32439181	3'UTR	novel		0.29
UCEC	chr20	32429978	Missense_Mutation	NA	A215T	0.26
UCEC	chr20	32434639	Frame_Shift_Del	rs781077343	*G645Vfs58**	0.5
UCEC	chr20	32433790	Missense_Mutation	novel	A531V	0.31
UCEC	chr20	32435286	Silent	novel	Q858Q	0.3
UCEC	chr20	32436672	Silent	novel	A1320A	0.33
UCEC	chr20	32437416	3'UTR	novel		0.47
UCEC	chr20	32436218	Missense_Mutation	novel	S1169Y	0.13
UCEC	chr20	32436521	Missense_Mutation	novel	R1270I	0.35
UCEC	chr20	32434704	Missense_Mutation	novel	S664R	0.42
UCEC	chr20	32372287	Intron	novel		0.44
UCEC	chr20	32431339	Missense_Mutation	novel	R246I	0.43
UCEC	chr20	32434944	Silent	rs372455823	G744G	0.43
UCEC	chr20	32433843	Missense_Mutation	NA	R549C	0.45
UCEC	chr20	32434471	Missense_Mutation	rs764414702	G587C	0.55
UCEC	chr20	32436811	Missense_Mutation	rs147456014	V1367I	0.49
UCEC	chr20	32429925	Missense_Mutation	novel	G197D	0.35
UCEC	chr20	32434691	Missense_Mutation	NA	G660D	0.43
UCEC	chr20	32366429	Missense_Mutation	NA	L35M	0.47	HARE-HTH
UCEC	chr20	32438623	3'UTR	novel		0.37
UCEC	chr20	32430021	Missense_Mutation	rs576523117	P229L	0.19
UCEC	chr20	32437532	3'UTR	novel		0.1
UCEC	chr20	32434639	Frame_Shift_Del	rs781077343	*G645Vfs58**	0.47
UCEC	chr20	32434571	Missense_Mutation	rs750708574	R620H	0.42
UCEC	chr20	32372350	Intron	novel		0.1
UCEC	chr20	32438355	3'UTR	novel		0.36
UCEC	chr20	32429406	Silent	rs74346706	N180N	0.19
UCEC	chr20	32435179	Missense_Mutation	novel	L823V	0.38
UCEC	chr20	32435382	Silent	rs140299198	L890L	0.23
UCEC	chr20	32431333	Missense_Mutation	rs139716375	R244H	0.46
UCEC	chr20	32435305	Missense_Mutation	rs147895689	E865K	0.32
UCEC	chr20	32437221	Silent	novel	S1503S	0.29
UCEC	chr20	32437604	3'UTR	novel		0.52
UCEC	chr20	32433693	Missense_Mutation	rs376089258	R499C	0.31
UCEC	chr20	32439015	3'UTR	novel		0.41
UCEC	chr20	32431411	Missense_Mutation	novel	S270Y	0.23
UCEC	chr20	32429339	Missense_Mutation	NA	A158V	0.16
UCEC	chr20	32435396	Missense_Mutation	novel	S895Y	0.3
UCEC	chr20	32434555	Missense_Mutation	novel	A615T	0.09
UCEC	chr20	32436790	Missense_Mutation	NA	P1360S	0.11
UCEC	chr20	32437183	Nonsense_Mutation	NA	Q1491*	0.3
UCEC	chr20	32431395	Missense_Mutation	novel	R265S	0.29
UCEC	chr20	32433608	Silent	rs767365077	S470S	0.31
UCEC	chr20	32435079	Silent	novel	C789C	0.35
UCEC	chr20	32372350	Intron	novel		0.06
UCEC	chr20	32436015	Frame_Shift_Ins	novel	*E1102Lfs9**	0.05
UCEC	chr20	32369020	Missense_Mutation	novel	T50N	0.31	HARE-HTH
UCEC	chr20	32436302	Missense_Mutation	novel	P1197L	0.41
UCEC	chr20	32433678	Missense_Mutation	NA	P494S	0.37
UCEC	chr20	32436394	Nonsense_Mutation	NA	E1228*	0.51
UCEC	chr20	32436530	Missense_Mutation	rs762720533	R1273H	0.33
UCEC	chr20	32429901	Missense_Mutation	novel	G189E	0.58
UCEC	chr20	32433436	Missense_Mutation	NA	R413Q	0.5
UCEC	chr20	32435304	Silent	rs147278940	D864D	0.14
UCEC	chr20	32435930	Missense_Mutation	novel	R1073H	0.35
UCEC	chr20	32436514	Missense_Mutation	novel	T1268A	0.16
UCEC	chr20	32437000	Missense_Mutation	novel	L1430I	0.18
UCEC	chr20	32431660	Missense_Mutation	novel	W320C	0.48
UCEC	chr20	32436449	Missense_Mutation	NA	V1246D	0.29
UCEC	chr20	32436298	Missense_Mutation	novel	A1196T	0.3
UCEC	chr20	32438143	3'UTR	novel		0.29
UCEC	chr20	32438032	3'UTR	novel		0.6

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LAML	DEL	0.0052	0.14746
READ	AMP	0.8667	1.9519e-21

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0016	Kaplan-Meier Survival Analysis
KIRC	0.015	Kaplan-Meier Survival Analysis
SARC	0.0051	Kaplan-Meier Survival Analysis
ACC	0.0065	Kaplan-Meier Survival Analysis
HNSC	0.0022	Kaplan-Meier Survival Analysis
SKCM	0.0061	Kaplan-Meier Survival Analysis
KIRP	0.0025	Kaplan-Meier Survival Analysis
UCEC	0.0037	Kaplan-Meier Survival Analysis
LIHC	0.0054	Kaplan-Meier Survival Analysis
LGG	0.002	Kaplan-Meier Survival Analysis
THCA	0.04	Kaplan-Meier Survival Analysis
UVM	0.035	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000171456 (Gene tree)
Gene ID: 171023
Gene Symbol: ASXL1
Alias: KIAA0978
Full Name: ASXL transcriptional regulator 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 80,990 bases
Position: chr20:32,358,330-32,439,319
Accession: 18318
RBP type: canonical RBP
Summary: This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000438654	HARE-HTH	PF05066.13	3.7e-19	1	1
ENSP00000493987	HARE-HTH	PF05066.13	3.7e-19	1	1
ENSP00000364839	HARE-HTH	PF05066.13	5.1e-17	1	1
ENSP00000480487	HARE-HTH	PF05066.13	5.1e-17	1	1
ENSP00000481978	HARE-HTH	PF05066.13	5.1e-17	1	1
ENSP00000364841	HARE-HTH	PF05066.13	6.9e-16	1	1
ENSP00000451216	HARE-HTH	PF05066.13	7e-16	1	1
ENSP00000305119	HARE-HTH	PF05066.13	3.2e-14	1	1
ENSP00000495053	HARE-HTH	PF05066.13	1.1e-13	1	1
ENSP00000495488	HARE-HTH	PF05066.13	5.1e-12	1	1
ENSP00000495003	HARE-HTH	PF05066.13	2.1e-11	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000470145	ASXL1-204	1085	-	-	- (aa)	-	-
ENST00000497249	ASXL1-205	495	-	ENSP00000451216	75 (aa)	-	H0YJC9
ENST00000644060	ASXL1-215	1202	-	-	- (aa)	-	-
ENST00000620121	ASXL1-212	5374	-	ENSP00000481978	1541 (aa)	-	Q8IXJ9
ENST00000619344	ASXL1-211	550	-	-	- (aa)	-	-
ENST00000649901	ASXL1-226	1261	-	ENSP00000497010	57 (aa)	-	UPI0004620DA2
ENST00000644587	ASXL1-217	1076	-	ENSP00000494813	84 (aa)	-	Q6P1M8
ENST00000555564	ASXL1-209	449	-	-	- (aa)	-	-
ENST00000645337	ASXL1-220	642	-	ENSP00000494077	85 (aa)	-	A0A2R8Y4U9
ENST00000645035	ASXL1-219	609	-	ENSP00000495495	75 (aa)	-	A0A2R8Y6F0
ENST00000613218	ASXL1-210	7038	XM_006723727	ENSP00000480487	1541 (aa)	XP_006723790	Q8IXJ9
ENST00000645688	ASXL1-222	500	-	ENSP00000495488	78 (aa)	-	A0A2R8Y6V0
ENST00000646985	ASXL1-224	6666	XM_006723728	ENSP00000495053	1480 (aa)	XP_006723791	A0A2R8Y5U1
ENST00000553345	ASXL1-207	809	-	-	- (aa)	-	-
ENST00000644168	ASXL1-216	1466	-	-	- (aa)	-	-
ENST00000644615	ASXL1-218	355	-	-	- (aa)	-	-
ENST00000306058	ASXL1-201	6591	XM_011528648	ENSP00000305119	1536 (aa)	XP_011526950	Q76L82
ENST00000555343	ASXL1-208	1034	-	ENSP00000480361	57 (aa)	-	A0A087WWN0
ENST00000647223	ASXL1-225	8056	-	-	- (aa)	-	-
ENST00000375687	ASXL1-202	7053	XM_006723730	ENSP00000364839	1541 (aa)	XP_006723793	Q8IXJ9
ENST00000375689	ASXL1-203	812	-	ENSP00000364841	81 (aa)	-	Q5JWS8
ENST00000542461	ASXL1-206	1068	-	ENSP00000438654	85 (aa)	-	Q498B9
ENST00000642676	ASXL1-213	535	-	ENSP00000496042	57 (aa)	-	A0A087WWN0
ENST00000643168	ASXL1-214	840	-	ENSP00000495003	135 (aa)	-	A0A2R8Y627
ENST00000645514	ASXL1-221	392	-	-	- (aa)	-	-
ENST00000646367	ASXL1-223	1065	-	ENSP00000493987	85 (aa)	-	Q498B9

Gene Model

Click here to download ENSG00000171456's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000171456	rs80188179	20	32421501	?	Hair color	30595370			EFO_0007822
ENSG00000171456	rs2424880	20	32380110	T	Smoking cessation (MTAG)	30643251	[0.0058-0.0119] unit decrease	0.00881264	EFO_0004319
ENSG00000171456	rs6058684	20	32410413	?	Lung function (FEV1/FVC)	30595370			EFO_0004713

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000171456's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000171456	ASXL1	100	75.000	ENSAPOG00000016599	-	83	74.713	Acanthochromis_polyacanthus
ENSG00000171456	ASXL1	99	97.647	ENSAMEG00000013339	ASXL1	100	81.266	Ailuropoda_melanoleuca
ENSG00000171456	ASXL1	100	75.000	ENSACIG00000013802	-	69	74.713	Amphilophus_citrinellus
ENSG00000171456	ASXL1	98	71.429	ENSACIG00000016887	-	87	70.667	Amphilophus_citrinellus
ENSG00000171456	ASXL1	100	75.000	ENSAPEG00000014832	-	83	74.713	Amphiprion_percula
ENSG00000171456	ASXL1	100	75.000	ENSATEG00000000035	-	78	74.713	Anabas_testudineus
ENSG00000171456	ASXL1	98	68.966	ENSACAG00000012597	-	71	63.889	Anolis_carolinensis
ENSG00000171456	ASXL1	100	89.474	ENSACAG00000008592	ASXL1	76	68.038	Anolis_carolinensis
ENSG00000171456	ASXL1	100	100.000	ENSANAG00000032163	ASXL1	100	100.000	Aotus_nancymaae
ENSG00000171456	ASXL1	100	70.175	ENSAMXG00000040278	asxl2	57	70.588	Astyanax_mexicanus
ENSG00000171456	ASXL1	100	66.667	ENSBTAG00000047003	ASXL3	91	43.403	Bos_taurus
ENSG00000171456	ASXL1	100	97.037	ENSBTAG00000031402	ASXL1	100	79.560	Bos_taurus
ENSG00000171456	ASXL1	100	98.246	ENSCJAG00000020708	ASXL1	100	98.246	Callithrix_jacchus
ENSG00000171456	ASXL1	100	96.491	ENSCAFG00000007219	ASXL1	100	81.435	Canis_familiaris
ENSG00000171456	ASXL1	100	66.667	ENSCAFG00020011763	-	82	44.484	Canis_lupus_dingo
ENSG00000171456	ASXL1	100	96.491	ENSCAFG00020004387	ASXL1	100	81.586	Canis_lupus_dingo
ENSG00000171456	ASXL1	100	97.778	ENSCHIG00000025369	ASXL1	100	78.849	Capra_hircus
ENSG00000171456	ASXL1	93	92.453	ENSCHIG00000016821	-	88	94.231	Capra_hircus
ENSG00000171456	ASXL1	100	98.519	ENSTSYG00000006907	ASXL1	100	84.656	Carlito_syrichta
ENSG00000171456	ASXL1	98	98.214	ENSCAPG00000016451	-	56	100.000	Cavia_aperea
ENSG00000171456	ASXL1	91	75.000	ENSCAPG00000005138	-	68	50.523	Cavia_aperea
ENSG00000171456	ASXL1	100	71.930	ENSCPOG00000007343	ASXL2	55	51.070	Cavia_porcellus
ENSG00000171456	ASXL1	100	96.491	ENSCPOG00000040350	ASXL1	100	78.548	Cavia_porcellus
ENSG00000171456	ASXL1	100	100.000	ENSCCAG00000023224	ASXL1	100	100.000	Cebus_capucinus
ENSG00000171456	ASXL1	100	100.000	ENSCATG00000034343	ASXL1	100	100.000	Cercocebus_atys
ENSG00000171456	ASXL1	100	71.930	ENSCLAG00000011428	ASXL2	55	50.765	Chinchilla_lanigera
ENSG00000171456	ASXL1	100	97.619	ENSCLAG00000017264	ASXL1	100	79.067	Chinchilla_lanigera
ENSG00000171456	ASXL1	100	98.519	ENSCSAG00000012615	ASXL1	100	94.354	Chlorocebus_sabaeus
ENSG00000171456	ASXL1	100	94.815	ENSCHOG00000007774	-	89	95.765	Choloepus_hoffmanni
ENSG00000171456	ASXL1	100	94.737	ENSCPBG00000027473	ASXL1	99	53.346	Chrysemys_picta_bellii
ENSG00000171456	ASXL1	100	100.000	ENSCANG00000030372	ASXL1	100	100.000	Colobus_angolensis_palliatus
ENSG00000171456	ASXL1	100	97.619	ENSCGRG00001002670	Asxl1	100	74.206	Cricetulus_griseus_chok1gshd
ENSG00000171456	ASXL1	100	73.684	ENSCGRG00000018294	Asxl2	59	47.863	Cricetulus_griseus_crigri
ENSG00000171456	ASXL1	100	96.491	ENSCGRG00000010091	Asxl1	100	73.736	Cricetulus_griseus_crigri
ENSG00000171456	ASXL1	100	75.000	ENSCSEG00000004640	-	91	75.000	Cynoglossus_semilaevis
ENSG00000171456	ASXL1	100	76.136	ENSCVAG00000011364	-	71	75.000	Cyprinodon_variegatus
ENSG00000171456	ASXL1	98	71.429	ENSCVAG00000022430	asxl2	60	50.588	Cyprinodon_variegatus
ENSG00000171456	ASXL1	98	98.214	ENSDORG00000028887	-	93	86.420	Dipodomys_ordii
ENSG00000171456	ASXL1	100	94.915	ENSETEG00000011100	ASXL1	100	71.997	Echinops_telfairi
ENSG00000171456	ASXL1	99	48.810	ENSEBUG00000015628	-	50	42.056	Eptatretus_burgeri
ENSG00000171456	ASXL1	100	97.619	ENSEASG00005003865	ASXL1	100	82.513	Equus_asinus_asinus
ENSG00000171456	ASXL1	99	97.619	ENSECAG00000022110	ASXL1	100	82.642	Equus_caballus
ENSG00000171456	ASXL1	100	98.246	ENSFCAG00000001908	ASXL1	100	80.983	Felis_catus
ENSG00000171456	ASXL1	100	94.737	ENSFALG00000005409	ASXL1	100	51.789	Ficedula_albicollis
ENSG00000171456	ASXL1	98	98.214	ENSFDAG00000005632	-	77	98.507	Fukomys_damarensis
ENSG00000171456	ASXL1	100	73.684	ENSFDAG00000008670	ASXL2	58	51.070	Fukomys_damarensis
ENSG00000171456	ASXL1	100	74.713	ENSGMOG00000009096	-	75	73.494	Gadus_morhua
ENSG00000171456	ASXL1	100	70.175	ENSGMOG00000004155	-	92	42.820	Gadus_morhua
ENSG00000171456	ASXL1	100	71.930	ENSGALG00000016531	ASXL2	52	56.944	Gallus_gallus
ENSG00000171456	ASXL1	100	94.737	ENSGALG00000006612	ASXL1	100	50.160	Gallus_gallus
ENSG00000171456	ASXL1	100	75.000	ENSGAFG00000014909	-	82	73.750	Gambusia_affinis
ENSG00000171456	ASXL1	100	73.864	ENSGACG00000012822	asxl1	100	50.763	Gasterosteus_aculeatus
ENSG00000171456	ASXL1	100	94.737	ENSGAGG00000020819	ASXL1	99	52.753	Gopherus_agassizii
ENSG00000171456	ASXL1	98	57.143	ENSGAGG00000011822	-	56	55.738	Gopherus_agassizii
ENSG00000171456	ASXL1	100	100.000	ENSGGOG00000003328	ASXL1	100	100.000	Gorilla_gorilla
ENSG00000171456	ASXL1	100	71.930	ENSHGLG00000006048	ASXL2	56	50.305	Heterocephalus_glaber_female
ENSG00000171456	ASXL1	99	97.590	ENSHGLG00000017863	-	82	97.590	Heterocephalus_glaber_female
ENSG00000171456	ASXL1	100	71.930	ENSHGLG00100010557	ASXL2	56	50.305	Heterocephalus_glaber_male
ENSG00000171456	ASXL1	100	94.737	ENSHGLG00100019165	ASXL1	99	79.974	Heterocephalus_glaber_male
ENSG00000171456	ASXL1	100	75.000	ENSHCOG00000013253	-	78	75.000	Hippocampus_comes
ENSG00000171456	ASXL1	98	71.429	ENSHCOG00000012992	-	87	46.575	Hippocampus_comes
ENSG00000171456	ASXL1	100	70.175	ENSIPUG00000023610	asxl2	57	70.588	Ictalurus_punctatus
ENSG00000171456	ASXL1	100	95.556	ENSSTOG00000027081	ASXL1	100	81.926	Ictidomys_tridecemlineatus
ENSG00000171456	ASXL1	98	96.552	ENSJJAG00000021569	-	75	95.775	Jaculus_jaculus
ENSG00000171456	ASXL1	100	75.000	ENSKMAG00000013765	-	88	73.750	Kryptolebias_marmoratus
ENSG00000171456	ASXL1	100	75.000	ENSLBEG00000012396	-	81	73.750	Labrus_bergylta
ENSG00000171456	ASXL1	100	70.175	ENSLBEG00000006710	asxl2	58	68.627	Labrus_bergylta
ENSG00000171456	ASXL1	98	85.714	ENSLACG00000002220	ASXL1	53	49.677	Latimeria_chalumnae
ENSG00000171456	ASXL1	100	81.176	ENSLOCG00000005771	asxl1	65	60.342	Lepisosteus_oculatus
ENSG00000171456	ASXL1	100	100.000	ENSMFAG00000029400	ASXL1	100	100.000	Macaca_fascicularis
ENSG00000171456	ASXL1	100	100.000	ENSMMUG00000007117	ASXL1	100	100.000	Macaca_mulatta
ENSG00000171456	ASXL1	100	100.000	ENSMNEG00000031201	ASXL1	100	100.000	Macaca_nemestrina
ENSG00000171456	ASXL1	100	100.000	ENSMLEG00000024749	ASXL1	100	100.000	Mandrillus_leucophaeus
ENSG00000171456	ASXL1	100	75.000	ENSMAMG00000008791	-	90	73.750	Mastacembelus_armatus
ENSG00000171456	ASXL1	100	94.737	ENSMGAG00000007588	ASXL1	99	50.799	Meleagris_gallopavo
ENSG00000171456	ASXL1	99	98.795	ENSMAUG00000000537	-	61	98.795	Mesocricetus_auratus
ENSG00000171456	ASXL1	100	97.037	ENSMICG00000038277	ASXL1	100	84.780	Microcebus_murinus
ENSG00000171456	ASXL1	99	98.795	ENSMOCG00000014066	-	98	98.795	Microtus_ochrogaster
ENSG00000171456	ASXL1	100	75.000	ENSMMOG00000017515	-	84	73.750	Mola_mola
ENSG00000171456	ASXL1	98	71.429	ENSMMOG00000011196	-	76	71.930	Mola_mola
ENSG00000171456	ASXL1	100	96.491	ENSMODG00000019457	ASXL1	100	61.172	Monodelphis_domestica
ENSG00000171456	ASXL1	98	71.429	ENSMALG00000020971	-	98	71.930	Monopterus_albus
ENSG00000171456	ASXL1	100	75.000	ENSMALG00000021361	-	77	73.750	Monopterus_albus
ENSG00000171456	ASXL1	100	98.246	MGP_CAROLIEiJ_G0024488	Asxl1	100	73.688	Mus_caroli
ENSG00000171456	ASXL1	100	73.684	MGP_CAROLIEiJ_G0017573	Asxl2	93	45.780	Mus_caroli
ENSG00000171456	ASXL1	100	73.684	ENSMUSG00000037486	Asxl2	95	46.402	Mus_musculus
ENSG00000171456	ASXL1	100	98.246	ENSMUSG00000042548	Asxl1	100	73.623	Mus_musculus
ENSG00000171456	ASXL1	100	98.246	MGP_PahariEiJ_G0025931	Asxl1	100	73.169	Mus_pahari
ENSG00000171456	ASXL1	100	98.246	MGP_SPRETEiJ_G0025409	Asxl1	100	73.752	Mus_spretus
ENSG00000171456	ASXL1	100	73.684	MGP_SPRETEiJ_G0018417	Asxl2	93	46.036	Mus_spretus
ENSG00000171456	ASXL1	100	96.491	ENSMPUG00000017872	ASXL1	100	79.789	Mustela_putorius_furo
ENSG00000171456	ASXL1	100	98.246	ENSMLUG00000001036	ASXL1	100	81.618	Myotis_lucifugus
ENSG00000171456	ASXL1	98	98.214	ENSNGAG00000020297	-	83	100.000	Nannospalax_galili
ENSG00000171456	ASXL1	100	75.000	ENSNBRG00000021565	-	93	75.000	Neolamprologus_brichardi
ENSG00000171456	ASXL1	100	100.000	ENSNLEG00000009794	ASXL1	100	100.000	Nomascus_leucogenys
ENSG00000171456	ASXL1	100	94.737	ENSOPRG00000016789	ASXL1	99	72.804	Ochotona_princeps
ENSG00000171456	ASXL1	99	98.795	ENSODEG00000012381	-	80	98.795	Octodon_degus
ENSG00000171456	ASXL1	98	71.429	ENSORLG00000028046	-	90	71.930	Oryzias_latipes
ENSG00000171456	ASXL1	100	75.000	ENSORLG00000027477	-	89	73.750	Oryzias_latipes
ENSG00000171456	ASXL1	100	75.000	ENSORLG00020003431	-	89	73.750	Oryzias_latipes_hni
ENSG00000171456	ASXL1	100	75.000	ENSORLG00015017723	-	89	73.750	Oryzias_latipes_hsok
ENSG00000171456	ASXL1	98	71.429	ENSORLG00015003122	-	81	65.333	Oryzias_latipes_hsok
ENSG00000171456	ASXL1	98	71.429	ENSOMEG00000005688	-	53	62.791	Oryzias_melastigma
ENSG00000171456	ASXL1	100	75.000	ENSOMEG00000011176	-	62	73.750	Oryzias_melastigma
ENSG00000171456	ASXL1	100	97.619	ENSOGAG00000008413	ASXL1	100	83.020	Otolemur_garnettii
ENSG00000171456	ASXL1	100	100.000	ENSPPAG00000028038	ASXL1	100	100.000	Pan_paniscus
ENSG00000171456	ASXL1	100	98.246	ENSPPRG00000009404	ASXL1	100	80.854	Panthera_pardus
ENSG00000171456	ASXL1	98	100.000	ENSPTIG00000008552	-	97	94.872	Panthera_tigris_altaica
ENSG00000171456	ASXL1	100	100.000	ENSPTRG00000013377	ASXL1	100	100.000	Pan_troglodytes
ENSG00000171456	ASXL1	100	100.000	ENSPANG00000025544	ASXL1	100	100.000	Papio_anubis
ENSG00000171456	ASXL1	100	75.000	ENSPKIG00000018277	asxl1	56	68.217	Paramormyrops_kingsleyae
ENSG00000171456	ASXL1	100	71.930	ENSPSIG00000012140	ASXL2	50	64.407	Pelodiscus_sinensis
ENSG00000171456	ASXL1	100	94.737	ENSPSIG00000002077	ASXL1	100	52.675	Pelodiscus_sinensis
ENSG00000171456	ASXL1	98	71.429	ENSPMGG00000024122	-	85	70.667	Periophthalmus_magnuspinnatus
ENSG00000171456	ASXL1	100	76.136	ENSPMGG00000017948	-	85	76.136	Periophthalmus_magnuspinnatus
ENSG00000171456	ASXL1	93	46.296	ENSPMAG00000000240	-	53	60.448	Petromyzon_marinus
ENSG00000171456	ASXL1	100	50.877	ENSPMAG00000007630	-	54	55.372	Petromyzon_marinus
ENSG00000171456	ASXL1	100	97.619	ENSPCIG00000025336	ASXL1	99	61.962	Phascolarctos_cinereus
ENSG00000171456	ASXL1	100	73.864	ENSPFOG00000017052	asxl1	51	55.233	Poecilia_formosa
ENSG00000171456	ASXL1	100	75.000	ENSPLAG00000004055	-	82	73.750	Poecilia_latipinna
ENSG00000171456	ASXL1	100	75.000	ENSPMEG00000000899	-	83	74.713	Poecilia_mexicana
ENSG00000171456	ASXL1	98	71.429	ENSPREG00000014267	-	87	70.667	Poecilia_reticulata
ENSG00000171456	ASXL1	100	75.000	ENSPREG00000008490	-	87	75.000	Poecilia_reticulata
ENSG00000171456	ASXL1	100	98.246	ENSPCOG00000020621	ASXL1	99	85.407	Propithecus_coquereli
ENSG00000171456	ASXL1	100	98.246	ENSPVAG00000008048	ASXL1	100	80.000	Pteropus_vampyrus
ENSG00000171456	ASXL1	100	70.175	ENSPNAG00000016179	asxl2	56	70.588	Pygocentrus_nattereri
ENSG00000171456	ASXL1	100	96.491	ENSRNOG00000061603	Asxl1	100	70.792	Rattus_norvegicus
ENSG00000171456	ASXL1	100	100.000	ENSRBIG00000038437	-	100	100.000	Rhinopithecus_bieti
ENSG00000171456	ASXL1	100	100.000	ENSRROG00000000172	ASXL1	100	100.000	Rhinopithecus_roxellana
ENSG00000171456	ASXL1	100	100.000	ENSSBOG00000023781	ASXL1	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000171456	ASXL1	100	75.000	ENSSFOG00015020389	-	69	74.713	Scleropages_formosus
ENSG00000171456	ASXL1	100	70.175	ENSSMAG00000013191	asxl2	57	70.588	Scophthalmus_maximus
ENSG00000171456	ASXL1	100	75.000	ENSSMAG00000003213	-	85	75.000	Scophthalmus_maximus
ENSG00000171456	ASXL1	100	75.000	ENSSDUG00000000824	-	58	74.713	Seriola_dumerili
ENSG00000171456	ASXL1	100	75.000	ENSSLDG00000024673	-	55	74.713	Seriola_lalandi_dorsalis
ENSG00000171456	ASXL1	100	93.431	ENSSARG00000001587	ASXL1	100	70.111	Sorex_araneus
ENSG00000171456	ASXL1	98	98.214	ENSSPUG00000018911	-	100	98.214	Sphenodon_punctatus
ENSG00000171456	ASXL1	100	66.667	ENSSPUG00000006158	-	97	41.254	Sphenodon_punctatus
ENSG00000171456	ASXL1	99	97.619	ENSSSCG00000007248	ASXL1	100	80.724	Sus_scrofa
ENSG00000171456	ASXL1	100	71.930	ENSTGUG00000014522	-	100	71.642	Taeniopygia_guttata
ENSG00000171456	ASXL1	100	94.737	ENSTGUG00000006483	ASXL1	92	64.899	Taeniopygia_guttata
ENSG00000171456	ASXL1	100	75.000	ENSTRUG00000021192	-	90	75.000	Takifugu_rubripes
ENSG00000171456	ASXL1	100	70.175	ENSTRUG00000023287	asxl2	62	54.118	Takifugu_rubripes
ENSG00000171456	ASXL1	100	70.690	ENSTNIG00000019288	asxl2	59	72.549	Tetraodon_nigroviridis
ENSG00000171456	ASXL1	95	69.048	ENSTNIG00000004355	asxl1	51	81.395	Tetraodon_nigroviridis
ENSG00000171456	ASXL1	100	92.500	ENSTBEG00000001054	-	74	82.848	Tupaia_belangeri
ENSG00000171456	ASXL1	100	98.246	ENSTTRG00000007957	ASXL1	95	97.826	Tursiops_truncatus
ENSG00000171456	ASXL1	100	71.930	ENSUAMG00000027962	ASXL2	55	50.305	Ursus_americanus
ENSG00000171456	ASXL1	93	55.556	ENSUAMG00000019013	-	77	56.364	Ursus_americanus
ENSG00000171456	ASXL1	98	98.214	ENSUAMG00000023398	-	87	96.000	Ursus_americanus
ENSG00000171456	ASXL1	100	71.930	ENSUMAG00000022345	ASXL2	56	50.456	Ursus_maritimus
ENSG00000171456	ASXL1	100	96.491	ENSUMAG00000024178	ASXL1	100	80.552	Ursus_maritimus
ENSG00000171456	ASXL1	100	96.491	ENSVPAG00000006169	ASXL1	75	96.154	Vicugna_pacos
ENSG00000171456	ASXL1	100	97.037	ENSVVUG00000005207	ASXL1	98	97.093	Vulpes_vulpes
ENSG00000171456	ASXL1	100	66.667	ENSXETG00000020547	asxl3	98	46.798	Xenopus_tropicalis
ENSG00000171456	ASXL1	100	75.000	ENSXCOG00000008255	-	82	73.750	Xiphophorus_couchianus
ENSG00000171456	ASXL1	98	71.429	ENSXCOG00000001543	-	79	70.667	Xiphophorus_couchianus
ENSG00000171456	ASXL1	100	75.000	ENSXMAG00000024079	-	82	73.750	Xiphophorus_maculatus
ENSG00000171456	ASXL1	100	70.175	ENSXMAG00000015679	asxl2	60	49.412	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000790	nuclear chromatin	21873635.	IBA	Component
GO:0000902	cell morphogenesis	-	IEA	Process
GO:0003007	heart morphogenesis	-	IEA	Process
GO:0003677	DNA binding	-	IEA	Function
GO:0003682	chromatin binding	21873635.	IBA	Function
GO:0003713	transcription coactivator activity	-	ISS	Function
GO:0005515	protein binding	16606617.18624398.19615732.20436459.22897849.27705803.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006351	transcription, DNA-templated	-	IEA	Process
GO:0009887	animal organ morphogenesis	21873635.	IBA	Process
GO:0016579	protein deubiquitination	-	TAS	Process
GO:0030097	hemopoiesis	-	IEA	Process
GO:0032526	response to retinoic acid	-	ISS	Process
GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway	-	ISS	Process
GO:0035517	PR-DUB complex	21873635.	IBA	Component
GO:0035517	PR-DUB complex	20436459.	IDA	Component
GO:0035522	monoubiquitinated histone H2A deubiquitination	20436459.	IDA	Process
GO:0042974	retinoic acid receptor binding	-	ISS	Function
GO:0042975	peroxisome proliferator activated receptor binding	21873635.	IBA	Function
GO:0042975	peroxisome proliferator activated receptor binding	-	ISS	Function
GO:0045599	negative regulation of fat cell differentiation	-	ISS	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	-	ISS	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0048386	positive regulation of retinoic acid receptor signaling pathway	-	ISS	Process
GO:0048538	thymus development	-	IEA	Process
GO:0048539	bone marrow development	-	IEA	Process
GO:0048872	homeostasis of number of cells	-	IEA	Process
GO:0060430	lung saccule development	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.