EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27348973	Overexpression of RRM2 in gastric cancer cell promotes their invasiveness via AKT/NF-??B signaling pathway.	Pharmazie	2016 May	Zhong Z	-
22569992	An analysis of human equilibrative nucleoside transporter-1, ribonucleoside reductase subunit M1, ribonucleoside reductase subunit M2, and excision repair cross-complementing gene-1 expression in patients with resected pancreas adenocarcinoma: implications for adjuvant treatment.	Cancer	2013 Jan 15	Fisher SB	doi: 10.1002/cncr.27619
23466567	Small interfering RNA (siRNA)-mediated silencing of the M2 subunit of ribonucleotide reductase: a novel therapeutic strategy in ovarian cancer.	Int J Gynecol Cancer	2013 May	Zhang M	doi: 10.1097/IGC.0b013e318287e2b3.
22884145	Overexpression of catalytic subunit M2 in patients with ovarian cancer.	Chin Med J (Engl)	2012 Jun	Wang LM	-
19250552	Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in vivo: implication of RRM2 in angiogenesis.	Mol Cancer	2009 Feb 28	Zhang K	doi: 10.1186/1476-4598-8-11.
27801665	CREB1 directly activates the transcription of ribonucleotide reductase small subunit M2 and promotes the aggressiveness of human colorectal cancer.	Oncotarget	2016 Nov 22	Fang Z	doi: 10.18632/oncotarget.12938.
27845331	BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity.	Nat Commun	2016 Nov 15	Rasmussen RD	doi: 10.1038/ncomms13398.
18941749	Evaluation of mRNA by Q-RTPCR and protein expression by AQUA of the M2 subunit of ribonucleotide reductase (RRM2) in human tumors.	Cancer Chemother Pharmacol	2009 Jun	Kolesar J	doi: 10.1007/s00280-008-0845-0
28624910	Clinical pharmacology and clinical trials of ribonucleotide reductase inhibitors: is it a viable cancer therapy?	J Cancer Res Clin Oncol	2017 Aug	Mannargudi MB	doi: 10.1007/s00432-017-2457-8
24756820	Targeting ribonucleotide reductase M2 subunit by small interfering RNA exerts anti-oncogenic effects in gastric adenocarcinoma.	Oncol Rep	2014 Jun	Kang W	doi: 10.3892/or.2014.3148
20825972	Expression of ribonucleotide reductase M2 subunit in gastric cancer and effects of RRM2 inhibition in vitro.	Hum Pathol	2010 Dec	Morikawa T	doi: 10.1016/j.humpath.2010.06.001
18278438	A phase 2 consortium (P2C) trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) for advanced adenocarcinoma of the pancreas.	Invest New Drugs	2008 Aug	Attia S	doi: 10.1007/s10637-008-9123-6
24637958	The expression of ribonucleotide reductase M2 in the carcinogenesis of uterine cervix and its relationship with clinicopathological characteristics and prognosis of cancer patients.	PLoS One	2014 Mar 17	Su YF	doi: 10.1371/journal.pone.0091644
20927319	Gene expression levels as predictive markers of outcome in pancreatic cancer after gemcitabine-based adjuvant chemotherapy.	Neoplasia	2010 Oct	Fujita H	-
14729598	In vitro characterization of enzymatic properties and inhibition of the p53R2 subunit of human ribonucleotide reductase.	Cancer Res	2004 Jan 1	Shao J	-
26001082	Ribonucleotide reductase subunit M2 predicts survival in subgroups of patients with non-small cell lung carcinoma: effects of gender and smoking status.	PLoS One	2015 May 22	Mah V	doi: 10.1371/journal.pone.0127600
25213022	Prognostic and therapeutic significance of ribonucleotide reductase small subunit M2 in estrogen-negative breast cancers.	BMC Cancer	2014 Sep 11	Zhang H	doi: 10.1186/1471-2407-14-664.
26718430	Investigation of some DNA repair genes association in non small cell lung cancer.	Cell Mol Biol (Noisy-le-grand)	2015 Dec 19	Coskunpinar E	-
23335963	Differential processing of let-7a precursors influences RRM2 expression and chemosensitivity in pancreatic cancer: role of LIN-28 and SET oncoprotein.	PLoS One	2013	Bhutia YD	doi: 10.1371/journal.pone.0053436
21965764	Expression status of ribonucleotide reductase small subunits hRRM2/p53R2 as prognostic biomarkers in stage I and II non-small cell lung cancer.	Anticancer Res	2011 Oct	Hsu NY	-
26093293	E2F1 promote the aggressiveness of human colorectal cancer by activating the ribonucleotide reductase small subunit M2.	Biochem Biophys Res Commun	2015 Aug 21	Fang Z	doi: 10.1016/j.bbrc.2015.06.103
24155212	Expression of RRM1 and RRM2 as a novel prognostic marker in advanced non-small cell lung cancer receiving chemotherapy.	Tumour Biol	2014 Mar	Wang L	doi: 10.1007/s13277-013-1255-4
24360663	The prognostic value of ribonucleotide reductase small subunit M2 in predicting recurrence for prostate cancers.	Urol Oncol	2014 Jan	Huang Y	doi: 10.1016/j.urolonc.2013.08.002.
21166702	Ribonucleotide reductase M2 subunit is a novel diagnostic marker and a potential therapeutic target in bladder cancer.	Histopathology	2010 Dec	Morikawa T	doi: 10.1111/j.1365-2559.2010.03725.x.
28327155	Vasohibin 2 reduces chemosensitivity to gemcitabine in pancreatic cancer cells via Jun proto-oncogene dependent transactivation of ribonucleotide reductase regulatory subunit M2.	Mol Cancer	2017 Mar 21	Tu M	doi: 10.1186/s12943-017-0619-6.
27517489	Suppression of c-Myc and RRM2 expression in pancreatic cancer cells by the sphingosine kinase-2 inhibitor ABC294640.	Oncotarget	2016 Sep 13	Lewis CS	doi: 10.18632/oncotarget.11112.
28507282	P53 suppresses ribonucleotide reductase via inhibiting mTORC1.	Oncotarget	2017 Jun 20	He Z	doi: 10.18632/oncotarget.17440.
28797284	Gambogic acid sensitizes gemcitabine efficacy in pancreatic cancer by reducing the expression of ribonucleotide reductase subunit-M2 (RRM2).	J Exp Clin Cancer Res	2017 Aug 10	Xia G	doi: 10.1186/s13046-017-0579-0.
28782484	Gene Expression Meta-Analysis of Potential Metastatic Breast Cancer Markers.	Curr Mol Med	2017	Bell R	doi: 10.2174/1566524017666170807144946.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr2	10123751	Missense_Mutation	novel	D112N	0.35
BLCA	chr2	10129041	Missense_Mutation	NA	E302K	0.3
BLCA	chr2	10123829	Missense_Mutation	novel	D138N	0.35
BLCA	chr2	10129246	Missense_Mutation	NA	E344Q	0.14
BLCA	chr2	10129434	3'UTR	novel		0.19
BLCA	chr2	10123733	Splice_Region	novel		0.28
BRCA	chr2	10128883	Silent	NA	K278K	0.22
BRCA	chr2	10123386	Splice_Site	novel	X59_splice	0.4
BRCA	chr2	10129082	Missense_Mutation	NA	M315I	0.11
BRCA	chr2	10122750	5'UTR	novel		0.38
BRCA	chr2	10127148	Silent	novel	S242S	0.08
CESC	chr2	10129413	3'UTR	novel		0.34
CESC	chr2	10129829	3'UTR	novel		0.41
CESC	chr2	10126882	Missense_Mutation	novel	L193F	0.3
CESC	chr2	10122873	Silent	NA	L25L	0.78
CESC	chr2	10126947	Frame_Shift_Ins	novel	*G215Wfs13**	0.1
CESC	chr2	10129403	3'UTR	novel		0.47
CESC	chr2	10123455	Silent	NA	V81V	0.22
CESC	chr2	10122784	5'UTR	novel		0.34
COAD	chr2	10123737	Missense_Mutation	NA	V107A	0.36
COAD	chr2	10122729	5'Flank	NA		0.33
COAD	chr2	10124783	Missense_Mutation	NA	M168V	0.21
COAD	chr2	10129156	Splice_Site	novel	X339_splice	0.1
COAD	chr2	10123403	Frame_Shift_Del	novel	*G66Afs8**	0.32
COAD	chr2	10129582	3'UTR	novel		0.38
COAD	chr2	10128862	Missense_Mutation	novel	D271E	0.03
ESCA	chr2	10129477	3'UTR	novel		0.13
GBM	chr2	10128941	Missense_Mutation	rs148740312	R298W	0.3
GBM	chr2	10129455	3'UTR	novel		0.07
HNSC	chr2	10126878	Frame_Shift_Ins	novel	*L193Sfs6**	0.07
HNSC	chr2	10129434	3'UTR	novel		0.27
KIRC	chr2	10129252	Missense_Mutation	NA	P346S	0.35
LIHC	chr2	10122644	5'Flank	rs765536182		0.4
LUAD	chr2	10129107	Missense_Mutation	NA	I324V	0.36
LUAD	chr2	10123431	Silent	NA	L73L	0.23
LUAD	chr2	10129432	3'UTR	novel		0.08
LUAD	chr2	10126961	Frame_Shift_Del	novel	*A219Vfs8**	0.18
LUAD	chr2	10126892	Missense_Mutation	novel	A196D	0.1
LUAD	chr2	10123797	Missense_Mutation	novel	I127T	0.47
LUAD	chr2	10124720	Missense_Mutation	NA	E147Q	0.1
LUSC	chr2	10127093	Missense_Mutation	rs753054700	R224H	0.39
OV	chr2	10124846	Missense_Mutation	NA	E189K	0.11
PRAD	chr2	10127093	Missense_Mutation	rs753054700	R224H	0.36
SARC	chr2	10129273	Missense_Mutation	novel	I353V	0.47
SKCM	chr2	10127138	Missense_Mutation	novel	S239F	0.35
SKCM	chr2	10123771	Silent	novel	S118S	0.29
SKCM	chr2	10124719	Splice_Region	novel	V146V	0.48
SKCM	chr2	10124720	Missense_Mutation	novel	E147K	0.48
SKCM	chr2	10123474	Missense_Mutation	rs72542791	H88Y	0.22
SKCM	chr2	10126963	Missense_Mutation	NA	T220P	0.24
SKCM	chr2	10129082	Missense_Mutation	NA	M315I	0.55
SKCM	chr2	10127119	Missense_Mutation	novel	G233S	0.41
SKCM	chr2	10127120	Missense_Mutation	novel	G233D	0.4
SKCM	chr2	10123407	Silent	NA	P65P	0.43
STAD	chr2	10129250	Missense_Mutation	NA	N345T	0.27
STAD	chr2	10128899	Missense_Mutation	novel	P284A	0.24
STAD	chr2	10129089	Missense_Mutation	NA	T318A	0.19
STAD	chr2	10127123	Frame_Shift_Del	novel	*F235Lfs24**	0.27
UCEC	chr2	10129361	Missense_Mutation	NA	S382Y	0.43
UCEC	chr2	10122685	5'Flank	NA		0.16
UCEC	chr2	10129486	3'UTR	rs151112936		0.32
UCEC	chr2	10123814	Missense_Mutation	NA	F133V	0.32
UCEC	chr2	10127157	Missense_Mutation	NA	W245C	0.25
UCEC	chr2	10129502	3'UTR	novel		0.4
UCEC	chr2	10124834	Missense_Mutation	novel	K185Q	0.4
UCEC	chr2	10129543	3'UTR	novel		0.06
UCEC	chr2	10128941	Missense_Mutation	rs148740312	R298W	0.38
UCEC	chr2	10129684	3'UTR	novel		0.19
UCEC	chr2	10129356	Missense_Mutation	rs371457678	E380D	0.22
UCEC	chr2	10129305	Silent	novel	E363E	0.32
UCEC	chr2	10129909	3'UTR	novel		0.33
UCEC	chr2	10128920	Nonsense_Mutation	novel	E291*	0.46
UCEC	chr2	10129735	3'UTR	novel		0.52
UCEC	chr2	10128942	Missense_Mutation	NA	R298Q	0.41
UCEC	chr2	10128941	Missense_Mutation	rs148740312	R298W	0.29
UCEC	chr2	10123527	Missense_Mutation	novel	E105D	0.4
UCEC	chr2	10129233	Splice_Site	novel	X340_splice	0.18
UCEC	chr2	10129436	3'UTR	novel		0.28
UCEC	chr2	10123784	Missense_Mutation	novel	E123K	0.06
UCEC	chr2	10127148	Silent	novel	S242S	0.36
UCEC	chr2	10129418	3'UTR	rs764059345		0.43
UCEC	chr2	10129133	Missense_Mutation	rs750055434	M332I	0.2
UCEC	chr2	10129418	3'UTR	rs764059345		0.46

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.3039	0.033813
CESC	AMP	0.2339	0.099937
KIRP	DEL	0.0278	0.08832
LUSC	DEL	0.0619	0.20634
OV	DEL	0.1503	0.087942
PAAD	DEL	0.0924	0.2014
TGCT	AMP	0.28	0.0050216
UCEC	DEL	0.0334	0.18809

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0047	Kaplan-Meier Survival Analysis
KIRC	0.0001	Kaplan-Meier Survival Analysis
SARC	0.021	Kaplan-Meier Survival Analysis
MESO	0.0002	Kaplan-Meier Survival Analysis
ACC	0.00013	Kaplan-Meier Survival Analysis
PRAD	0.0099	Kaplan-Meier Survival Analysis
LUSC	0.039	Kaplan-Meier Survival Analysis
COAD	0.024	Kaplan-Meier Survival Analysis
PAAD	0.001	Kaplan-Meier Survival Analysis
PCPG	0.029	Kaplan-Meier Survival Analysis
BLCA	0.035	Kaplan-Meier Survival Analysis
READ	0.017	Kaplan-Meier Survival Analysis
KICH	0.0039	Kaplan-Meier Survival Analysis
UCEC	0.015	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
DLBC	0.041	Kaplan-Meier Survival Analysis
LUAD	0.0001	Kaplan-Meier Survival Analysis
UVM	0.00019	Kaplan-Meier Survival Analysis
OV	0.021	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000171848 (Gene tree)
Gene ID: 6241
Gene Symbol: RRM2
Alias: N
Full Name: ribonucleotide reductase regulatory subunit M2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 10,722 bases
Position: chr2:10,120,698-10,131,419
Accession: 10452
RBP type: non-canonical RBP
Summary: This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
26838063	A molecular mechanism realizing sequence-specific recognition of nucleic acids by TDP-43.	Sci Rep	2016 Feb 3	Furukawa Y	doi: 10.1038/srep20576.
24464995	The crystal structure of TDP-43 RRM1-DNA complex reveals the specific recognition for UG- and TG-rich nucleic acids.	Nucleic Acids Res	2014 Apr	Kuo PH	doi: 10.1093/nar/gkt1407
12242302	Highly selective actions of HuR in antagonizing AU-rich element-mediated mRNA destabilization.	Mol Cell Biol	2002 Oct	Chen CY	-
15341728	Structure and RNA interactions of the N-terminal RRM domains of PTB.	Structure	2004 Sep	Simpson PJ	-
17606619	eIF4G, eIFiso4G, and eIF4B bind the poly(A)-binding protein through overlapping sites within the RNA recognition motif domains.	J Biol Chem	2007 Aug 31	Cheng S	-
24824036	The binding of TIA-1 to RNA C-rich sequences is driven by its C-terminal RRM domain.	RNA Biol	2014	Cruz-Gallardo I	-
28934484	Regulation of HuR structure and function by dihydrotanshinone-I.	Nucleic Acids Res	2017 Sep 19	Lal P	doi: 10.1093/nar/gkx623.
31262091	NMR Fragment-Based Screening against Tandem RNA Recognition Motifs of TDP-43.	Int J Mol Sci	2019 Jun 30	Nshogoza G	doi: 10.3390/ijms20133230.
10079173	Analysis of the RNA recognition motifs of human neuronal ELAV-like proteins in binding to a cytokine mRNA.	Biochem Biophys Res Commun	1999 Mar 16	Sakai K	-
9305981	Multiple RRMs contribute to RNA binding specificity and affinity for polypyrimidine tract binding protein.	Biochemistry	1997 Sep 30	Perez I	-
8576255	Individual RNA recognition motifs of TIA-1 and TIAR have different RNA binding specificities.	J Biol Chem	1996 Feb 2	Dember LM	-
23129761	Sjogren syndrome antigen B (SSB)/La promotes global microRNA expression by binding microRNA precursors through stem-loop recognition.	J Biol Chem	2013 Jan 4	Liang C	doi: 10.1074/jbc.M112.401323
21743084	Sequence determinants for the tandem recognition of UGU and CUG rich RNA elements by the two N--terminal RRMs of CELF1.	Nucleic Acids Res	2011 Oct	Edwards J	doi: 10.1093/nar/gkr510
10499800	Recognition of polyadenylate RNA by the poly(A)-binding protein.	Cell	1999 Sep 17	Deo RC	-
12239318	Selective translation of eukaryotic mRNAs: functional molecular analysis of GRSF-1, a positive regulator of influenza virus protein synthesis.	J Virol	2002 Oct	Kash JC	-
15060081	Nuclear trafficking of La protein depends on a newly identified nucleolar localization signal and the ability to bind RNA.	J Biol Chem	2004 Jun 18	Horke S	-
14973222	ETR-3 and CELF4 protein domains required for RNA binding and splicing activity in vivo.	Nucleic Acids Res	2004 Feb 18	Singh G	-
14671117	The genome of canarypox virus.	J Virol	2004 Jan	Tulman ER	-
21846467	A structural insight into the C-terminal RNA recognition motifs of T-cell intracellular antigen-1 protein.	FEBS Lett	2011 Oct 3	Aroca A	doi: 10.1016/j.febslet.2011.07.037
21788335	Defining the Mer1 and Nam8 meiotic splicing regulons by cDNA rescue.	RNA	2011 Sep	Qiu ZR	doi: 10.1261/rna.2792011
21208980	Determinants of Nam8-dependent splicing of meiotic pre-mRNAs.	Nucleic Acids Res	2011 Apr	Qiu ZR	doi: 10.1093/nar/gkq1328
25356590	Multifaceted genome control by Set1 Dependent and Independent of H3K4 methylation and the Set1C/COMPASS complex.	PLoS Genet	2014 Oct 30	Mikheyeva IV	doi: 10.1371/journal.pgen.1004740
26697894	Dynamic Distribution and Interaction of the Arabidopsis SRSF1 Subfamily Splicing Factors.	Plant Physiol	2016 Feb	Stankovic N	doi: 10.1104/pp.15.01338
26657638	Human polypyrimidine tract-binding protein interacts with mitochondrial tRNA(Thr) in the cytosol.	Nucleic Acids Res	2016 Feb 18	Marnef A	doi: 10.1093/nar/gkv1355
29450990	Splicing Site Recognition by Synergy of Three Domains in Splicing Factor RBM10.	Biochemistry	2018 Mar 13	Serrano P	doi: 10.1021/acs.biochem.7b01242
29618637	Interaction of 2',3'-cAMP with Rbp47b Plays a Role in Stress Granule Formation.	Plant Physiol	2018 May	Kosmacz M	doi: 10.1104/pp.18.00285
30694439	1H, 15N and 13C backbone assignment of apo TDP-43 RNA recognition motifs.	Biomol NMR Assign	2019 Apr	Scott DD	doi: 10.1007/s12104-018-09870-x
22839758	Solution structure of the second RRM domain of RBM5 and its unusual binding characters for different RNA targets.	Biochemistry	2012 Aug 21	Song Z	doi: 10.1021/bi300539t
21829725	Functional characterization of the HuR:CD83 mRNA interaction.	PLoS One	2011	Pieper D	doi: 10.1371/journal.pone.0023290
20798862	Regulation of HuR by DNA Damage Response Kinases.	J Nucleic Acids	2010 Jul 25	Kim HH	doi: 10.4061/2010/981487.
23864387	Insulin-like growth factor-I receptor is suppressed through transcriptional repression and mRNA destabilization by a novel energy restriction-mimetic agent.	Carcinogenesis	2013 Dec	Chu PC	doi: 10.1093/carcin/bgt251
26362209	The first echinoderm poly-U-binding factor 60 kDa (PUF60) from sea cucumber (Stichopus monotuberculatus): Molecular characterization, inducible expression and involvement of apoptosis.	Fish Shellfish Immunol	2015 Nov	Ren C	doi: 10.1016/j.fsi.2015.09.001
30356856	The RNA-Recognition Motifs of TAR DNA-Binding Protein 43 May Play a Role in the Aberrant Self-Assembly of the Protein.	Front Mol Neurosci	2018 Oct 9	Zacco E	doi: 10.3389/fnmol.2018.00372
31169309	Long noncoding RNA LINC00958 regulates cell sensitivity to radiotherapy through RRM2 by binding to microRNA-5095 in cervical cancer.	J Cell Physiol	2019 Jun 6	Zhao H	doi: 10.1002/jcp.28902

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000498343	RRM2-210	560	-	-	- (aa)	-	-
ENST00000485717	RRM2-207	573	-	-	- (aa)	-	-
ENST00000607140	RRM2-211	332	-	-	- (aa)	-	-
ENST00000641198	RRM2-213	3431	-	ENSP00000493399	389 (aa)	-	P31350
ENST00000474701	RRM2-206	1060	-	ENSP00000419177	289 (aa)	-	C9JXC1
ENST00000462343	RRM2-205	454	-	-	- (aa)	-	-
ENST00000487591	RRM2-208	592	-	-	- (aa)	-	-
ENST00000491447	RRM2-209	644	-	-	- (aa)	-	-
ENST00000459969	RRM2-203	787	-	-	- (aa)	-	-
ENST00000304567	RRM2-201	3271	-	ENSP00000302955	389 (aa)	-	P31350
ENST00000461327	RRM2-204	580	-	-	- (aa)	-	-
ENST00000360566	RRM2-202	3673	-	ENSP00000353770	449 (aa)	-	P31350
ENST00000615152	RRM2-212	3434	-	ENSP00000484183	449 (aa)	-	P31350

Gene Model

Click here to download ENSG00000171848's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00230	Purine metabolism	KEGG
hsa00240	Pyrimidine metabolism	KEGG
hsa00480	Glutathione metabolism	KEGG
hsa00983	Drug metabolism - other enzymes	KEGG
hsa01100	Metabolic pathways	KEGG
hsa04115	p53 signaling pathway	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000171848	Platelet Function Tests	1.2338300E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000171848's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000171848	RRM2	94	69.597	YJL026W	RNR2	82	68.712	Saccharomyces_cerevisiae
ENSG00000171848	RRM2	94	49.265	YGR180C	RNR4	94	48.148	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle	-	TAS	Process
GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	21873635.	IBA	Function
GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	-	ISS	Function
GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	1627826.	NAS	Function
GO:0005515	protein binding	17726094.21336276.22632967.	IPI	Function
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005971	ribonucleoside-diphosphate reductase complex	-	IEA	Component
GO:0006260	DNA replication	-	IEA	Process
GO:0008199	ferric iron binding	-	IEA	Function
GO:0009263	deoxyribonucleotide biosynthetic process	21873635.	IBA	Process
GO:0009263	deoxyribonucleotide biosynthetic process	-	ISS	Process
GO:0015949	nucleobase-containing small molecule interconversion	-	TAS	Process
GO:0042803	protein homodimerization activity	-	IEA	Function
GO:0051290	protein heterotetramerization	-	IEA	Process
GO:0055114	oxidation-reduction process	-	IEA	Process
GO:0070317	negative regulation of G0 to G1 transition	-	TAS	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.