EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
27348973Overexpression of RRM2 in gastric cancer cell promotes their invasiveness via AKT/NF-??B signaling pathway.Pharmazie2016 MayZhong Z-
22569992An analysis of human equilibrative nucleoside transporter-1, ribonucleoside reductase subunit M1, ribonucleoside reductase subunit M2, and excision repair cross-complementing gene-1 expression in patients with resected pancreas adenocarcinoma: implications for adjuvant treatment.Cancer2013 Jan 15Fisher SBdoi: 10.1002/cncr.27619
23466567Small interfering RNA (siRNA)-mediated silencing of the M2 subunit of ribonucleotide reductase: a novel therapeutic strategy in ovarian cancer.Int J Gynecol Cancer2013 MayZhang Mdoi: 10.1097/IGC.0b013e318287e2b3.
22884145Overexpression of catalytic subunit M2 in patients with ovarian cancer.Chin Med J (Engl)2012 JunWang LM-
19250552Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in vivo: implication of RRM2 in angiogenesis.Mol Cancer2009 Feb 28Zhang Kdoi: 10.1186/1476-4598-8-11.
27801665CREB1 directly activates the transcription of ribonucleotide reductase small subunit M2 and promotes the aggressiveness of human colorectal cancer.Oncotarget2016 Nov 22Fang Zdoi: 10.18632/oncotarget.12938.
27845331BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity.Nat Commun2016 Nov 15Rasmussen RDdoi: 10.1038/ncomms13398.
18941749Evaluation of mRNA by Q-RTPCR and protein expression by AQUA of the M2 subunit of ribonucleotide reductase (RRM2) in human tumors.Cancer Chemother Pharmacol2009 JunKolesar Jdoi: 10.1007/s00280-008-0845-0
28624910Clinical pharmacology and clinical trials of ribonucleotide reductase inhibitors: is it a viable cancer therapy?J Cancer Res Clin Oncol2017 AugMannargudi MBdoi: 10.1007/s00432-017-2457-8
24756820Targeting ribonucleotide reductase M2 subunit by small interfering RNA exerts anti-oncogenic effects in gastric adenocarcinoma.Oncol Rep2014 JunKang Wdoi: 10.3892/or.2014.3148
20825972Expression of ribonucleotide reductase M2 subunit in gastric cancer and effects of RRM2 inhibition in vitro.Hum Pathol2010 DecMorikawa Tdoi: 10.1016/j.humpath.2010.06.001
18278438A phase 2 consortium (P2C) trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) for advanced adenocarcinoma of the pancreas.Invest New Drugs2008 AugAttia Sdoi: 10.1007/s10637-008-9123-6
24637958The expression of ribonucleotide reductase M2 in the carcinogenesis of uterine cervix and its relationship with clinicopathological characteristics and prognosis of cancer patients.PLoS One2014 Mar 17Su YFdoi: 10.1371/journal.pone.0091644
20927319Gene expression levels as predictive markers of outcome in pancreatic cancer after gemcitabine-based adjuvant chemotherapy.Neoplasia2010 OctFujita H-
14729598In vitro characterization of enzymatic properties and inhibition of the p53R2 subunit of human ribonucleotide reductase.Cancer Res2004 Jan 1Shao J-
26001082Ribonucleotide reductase subunit M2 predicts survival in subgroups of patients with non-small cell lung carcinoma: effects of gender and smoking status.PLoS One2015 May 22Mah Vdoi: 10.1371/journal.pone.0127600
25213022Prognostic and therapeutic significance of ribonucleotide reductase small subunit M2 in estrogen-negative breast cancers.BMC Cancer2014 Sep 11Zhang Hdoi: 10.1186/1471-2407-14-664.
26718430Investigation of some DNA repair genes association in non small cell lung cancer.Cell Mol Biol (Noisy-le-grand)2015 Dec 19Coskunpinar E-
23335963Differential processing of let-7a precursors influences RRM2 expression and chemosensitivity in pancreatic cancer: role of LIN-28 and SET oncoprotein.PLoS One2013Bhutia YDdoi: 10.1371/journal.pone.0053436
21965764Expression status of ribonucleotide reductase small subunits hRRM2/p53R2 as prognostic biomarkers in stage I and II non-small cell lung cancer.Anticancer Res2011 OctHsu NY-
26093293E2F1 promote the aggressiveness of human colorectal cancer by activating the ribonucleotide reductase small subunit M2.Biochem Biophys Res Commun2015 Aug 21Fang Zdoi: 10.1016/j.bbrc.2015.06.103
24155212Expression of RRM1 and RRM2 as a novel prognostic marker in advanced non-small cell lung cancer receiving chemotherapy.Tumour Biol2014 MarWang Ldoi: 10.1007/s13277-013-1255-4
24360663The prognostic value of ribonucleotide reductase small subunit M2 in predicting recurrence for prostate cancers.Urol Oncol2014 JanHuang Ydoi: 10.1016/j.urolonc.2013.08.002.
21166702Ribonucleotide reductase M2 subunit is a novel diagnostic marker and a potential therapeutic target in bladder cancer.Histopathology2010 DecMorikawa Tdoi: 10.1111/j.1365-2559.2010.03725.x.
28327155Vasohibin 2 reduces chemosensitivity to gemcitabine in pancreatic cancer cells via Jun proto-oncogene dependent transactivation of ribonucleotide reductase regulatory subunit M2.Mol Cancer2017 Mar 21Tu Mdoi: 10.1186/s12943-017-0619-6.
27517489Suppression of c-Myc and RRM2 expression in pancreatic cancer cells by the sphingosine kinase-2 inhibitor ABC294640.Oncotarget2016 Sep 13Lewis CSdoi: 10.18632/oncotarget.11112.
28507282P53 suppresses ribonucleotide reductase via inhibiting mTORC1.Oncotarget2017 Jun 20He Zdoi: 10.18632/oncotarget.17440.
28797284Gambogic acid sensitizes gemcitabine efficacy in pancreatic cancer by reducing the expression of ribonucleotide reductase subunit-M2 (RRM2).J Exp Clin Cancer Res2017 Aug 10Xia Gdoi: 10.1186/s13046-017-0579-0.
28782484Gene Expression Meta-Analysis of Potential Metastatic Breast Cancer Markers.Curr Mol Med2017Bell Rdoi: 10.2174/1566524017666170807144946.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr210123751Missense_MutationnovelD112N0.35
BLCAchr210129041Missense_MutationNAE302K0.3
BLCAchr210123829Missense_MutationnovelD138N0.35
BLCAchr210129246Missense_MutationNAE344Q0.14
BLCAchr2101294343'UTRnovel0.19
BLCAchr210123733Splice_Regionnovel0.28
BRCAchr210128883SilentNAK278K0.22
BRCAchr210123386Splice_SitenovelX59_splice0.4
BRCAchr210129082Missense_MutationNAM315I0.11
BRCAchr2101227505'UTRnovel0.38
BRCAchr210127148SilentnovelS242S0.08
CESCchr2101294133'UTRnovel0.34
CESCchr2101298293'UTRnovel0.41
CESCchr210126882Missense_MutationnovelL193F0.3
CESCchr210122873SilentNAL25L0.78
CESCchr210126947Frame_Shift_InsnovelG215Wfs*130.1
CESCchr2101294033'UTRnovel0.47
CESCchr210123455SilentNAV81V0.22
CESCchr2101227845'UTRnovel0.34
COADchr210123737Missense_MutationNAV107A0.36
COADchr2101227295'FlankNA0.33
COADchr210124783Missense_MutationNAM168V0.21
COADchr210129156Splice_SitenovelX339_splice0.1
COADchr210123403Frame_Shift_DelnovelG66Afs*80.32
COADchr2101295823'UTRnovel0.38
COADchr210128862Missense_MutationnovelD271E0.03
ESCAchr2101294773'UTRnovel0.13
GBMchr210128941Missense_Mutationrs148740312R298W0.3
GBMchr2101294553'UTRnovel0.07
HNSCchr210126878Frame_Shift_InsnovelL193Sfs*60.07
HNSCchr2101294343'UTRnovel0.27
KIRCchr210129252Missense_MutationNAP346S0.35
LIHCchr2101226445'Flankrs7655361820.4
LUADchr210129107Missense_MutationNAI324V0.36
LUADchr210123431SilentNAL73L0.23
LUADchr2101294323'UTRnovel0.08
LUADchr210126961Frame_Shift_DelnovelA219Vfs*80.18
LUADchr210126892Missense_MutationnovelA196D0.1
LUADchr210123797Missense_MutationnovelI127T0.47
LUADchr210124720Missense_MutationNAE147Q0.1
LUSCchr210127093Missense_Mutationrs753054700R224H0.39
OVchr210124846Missense_MutationNAE189K0.11
PRADchr210127093Missense_Mutationrs753054700R224H0.36
SARCchr210129273Missense_MutationnovelI353V0.47
SKCMchr210127138Missense_MutationnovelS239F0.35
SKCMchr210123771SilentnovelS118S0.29
SKCMchr210124719Splice_RegionnovelV146V0.48
SKCMchr210124720Missense_MutationnovelE147K0.48
SKCMchr210123474Missense_Mutationrs72542791H88Y0.22
SKCMchr210126963Missense_MutationNAT220P0.24
SKCMchr210129082Missense_MutationNAM315I0.55
SKCMchr210127119Missense_MutationnovelG233S0.41
SKCMchr210127120Missense_MutationnovelG233D0.4
SKCMchr210123407SilentNAP65P0.43
STADchr210129250Missense_MutationNAN345T0.27
STADchr210128899Missense_MutationnovelP284A0.24
STADchr210129089Missense_MutationNAT318A0.19
STADchr210127123Frame_Shift_DelnovelF235Lfs*240.27
UCECchr210129361Missense_MutationNAS382Y0.43
UCECchr2101226855'FlankNA0.16
UCECchr2101294863'UTRrs1511129360.32
UCECchr210123814Missense_MutationNAF133V0.32
UCECchr210127157Missense_MutationNAW245C0.25
UCECchr2101295023'UTRnovel0.4
UCECchr210124834Missense_MutationnovelK185Q0.4
UCECchr2101295433'UTRnovel0.06
UCECchr210128941Missense_Mutationrs148740312R298W0.38
UCECchr2101296843'UTRnovel0.19
UCECchr210129356Missense_Mutationrs371457678E380D0.22
UCECchr210129305SilentnovelE363E0.32
UCECchr2101299093'UTRnovel0.33
UCECchr210128920Nonsense_MutationnovelE291*0.46
UCECchr2101297353'UTRnovel0.52
UCECchr210128942Missense_MutationNAR298Q0.41
UCECchr210128941Missense_Mutationrs148740312R298W0.29
UCECchr210123527Missense_MutationnovelE105D0.4
UCECchr210129233Splice_SitenovelX340_splice0.18
UCECchr2101294363'UTRnovel0.28
UCECchr210123784Missense_MutationnovelE123K0.06
UCECchr210127148SilentnovelS242S0.36
UCECchr2101294183'UTRrs7640593450.43
UCECchr210129133Missense_Mutationrs750055434M332I0.2
UCECchr2101294183'UTRrs7640593450.46

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCAAMP0.30390.033813
CESCAMP0.23390.099937
KIRPDEL0.02780.08832
LUSCDEL0.06190.20634
OVDEL0.15030.087942
PAADDEL0.09240.2014
TGCTAMP0.280.0050216
UCECDEL0.03340.18809

Survival Analysis
CancerP-value Q-value
THYM0.0047

Kaplan-Meier Survival Analysis

KIRC0.0001

Kaplan-Meier Survival Analysis

SARC0.021

Kaplan-Meier Survival Analysis

MESO0.0002

Kaplan-Meier Survival Analysis

ACC0.00013

Kaplan-Meier Survival Analysis

PRAD0.0099

Kaplan-Meier Survival Analysis

LUSC0.039

Kaplan-Meier Survival Analysis

COAD0.024

Kaplan-Meier Survival Analysis

PAAD0.001

Kaplan-Meier Survival Analysis

PCPG0.029

Kaplan-Meier Survival Analysis

BLCA0.035

Kaplan-Meier Survival Analysis

READ0.017

Kaplan-Meier Survival Analysis

KICH0.0039

Kaplan-Meier Survival Analysis

UCEC0.015

Kaplan-Meier Survival Analysis

LIHC0.0001

Kaplan-Meier Survival Analysis

DLBC0.041

Kaplan-Meier Survival Analysis

LUAD0.0001

Kaplan-Meier Survival Analysis

UVM0.00019

Kaplan-Meier Survival Analysis

OV0.021

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000171848 (Gene tree)
Gene ID
6241
Gene Symbol
RRM2
Alias
N
Full Name
ribonucleotide reductase regulatory subunit M2
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
10,722 bases
Position
chr2:10,120,698-10,131,419
Accession
10452
RBP type
non-canonical RBP
Summary
This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
26838063A molecular mechanism realizing sequence-specific recognition of nucleic acids by TDP-43.Sci Rep2016 Feb 3Furukawa Ydoi: 10.1038/srep20576.
24464995The crystal structure of TDP-43 RRM1-DNA complex reveals the specific recognition for UG- and TG-rich nucleic acids.Nucleic Acids Res2014 AprKuo PHdoi: 10.1093/nar/gkt1407
12242302Highly selective actions of HuR in antagonizing AU-rich element-mediated mRNA destabilization.Mol Cell Biol2002 OctChen CY-
15341728Structure and RNA interactions of the N-terminal RRM domains of PTB.Structure2004 SepSimpson PJ-
17606619eIF4G, eIFiso4G, and eIF4B bind the poly(A)-binding protein through overlapping sites within the RNA recognition motif domains.J Biol Chem2007 Aug 31Cheng S-
24824036The binding of TIA-1 to RNA C-rich sequences is driven by its C-terminal RRM domain.RNA Biol2014Cruz-Gallardo I-
28934484Regulation of HuR structure and function by dihydrotanshinone-I.Nucleic Acids Res2017 Sep 19Lal Pdoi: 10.1093/nar/gkx623.
31262091NMR Fragment-Based Screening against Tandem RNA Recognition Motifs of TDP-43.Int J Mol Sci2019 Jun 30Nshogoza Gdoi: 10.3390/ijms20133230.
10079173Analysis of the RNA recognition motifs of human neuronal ELAV-like proteins in binding to a cytokine mRNA.Biochem Biophys Res Commun1999 Mar 16Sakai K-
9305981Multiple RRMs contribute to RNA binding specificity and affinity for polypyrimidine tract binding protein.Biochemistry1997 Sep 30Perez I-
8576255Individual RNA recognition motifs of TIA-1 and TIAR have different RNA binding specificities.J Biol Chem1996 Feb 2Dember LM-
23129761Sjogren syndrome antigen B (SSB)/La promotes global microRNA expression by binding microRNA precursors through stem-loop recognition.J Biol Chem2013 Jan 4Liang Cdoi: 10.1074/jbc.M112.401323
21743084Sequence determinants for the tandem recognition of UGU and CUG rich RNA elements by the two N--terminal RRMs of CELF1.Nucleic Acids Res2011 OctEdwards Jdoi: 10.1093/nar/gkr510
10499800Recognition of polyadenylate RNA by the poly(A)-binding protein.Cell1999 Sep 17Deo RC-
12239318Selective translation of eukaryotic mRNAs: functional molecular analysis of GRSF-1, a positive regulator of influenza virus protein synthesis.J Virol2002 OctKash JC-
15060081Nuclear trafficking of La protein depends on a newly identified nucleolar localization signal and the ability to bind RNA.J Biol Chem2004 Jun 18Horke S-
14973222ETR-3 and CELF4 protein domains required for RNA binding and splicing activity in vivo.Nucleic Acids Res2004 Feb 18Singh G-
14671117The genome of canarypox virus.J Virol2004 JanTulman ER-
21846467A structural insight into the C-terminal RNA recognition motifs of T-cell intracellular antigen-1 protein.FEBS Lett2011 Oct 3Aroca Adoi: 10.1016/j.febslet.2011.07.037
21788335Defining the Mer1 and Nam8 meiotic splicing regulons by cDNA rescue.RNA2011 SepQiu ZRdoi: 10.1261/rna.2792011
21208980Determinants of Nam8-dependent splicing of meiotic pre-mRNAs.Nucleic Acids Res2011 AprQiu ZRdoi: 10.1093/nar/gkq1328
25356590Multifaceted genome control by Set1 Dependent and Independent of H3K4 methylation and the Set1C/COMPASS complex.PLoS Genet2014 Oct 30Mikheyeva IVdoi: 10.1371/journal.pgen.1004740
26697894Dynamic Distribution and Interaction of the Arabidopsis SRSF1 Subfamily Splicing Factors.Plant Physiol2016 FebStankovic Ndoi: 10.1104/pp.15.01338
26657638Human polypyrimidine tract-binding protein interacts with mitochondrial tRNA(Thr) in the cytosol.Nucleic Acids Res2016 Feb 18Marnef Adoi: 10.1093/nar/gkv1355
29450990Splicing Site Recognition by Synergy of Three Domains in Splicing Factor RBM10.Biochemistry2018 Mar 13Serrano Pdoi: 10.1021/acs.biochem.7b01242
29618637Interaction of 2',3'-cAMP with Rbp47b Plays a Role in Stress Granule Formation.Plant Physiol2018 MayKosmacz Mdoi: 10.1104/pp.18.00285
306944391H, 15N and 13C backbone assignment of apo TDP-43 RNA recognition motifs.Biomol NMR Assign2019 AprScott DDdoi: 10.1007/s12104-018-09870-x
22839758Solution structure of the second RRM domain of RBM5 and its unusual binding characters for different RNA targets.Biochemistry2012 Aug 21Song Zdoi: 10.1021/bi300539t
21829725Functional characterization of the HuR:CD83 mRNA interaction.PLoS One2011Pieper Ddoi: 10.1371/journal.pone.0023290
20798862Regulation of HuR by DNA Damage Response Kinases.J Nucleic Acids2010 Jul 25Kim HHdoi: 10.4061/2010/981487.
23864387Insulin-like growth factor-I receptor is suppressed through transcriptional repression and mRNA destabilization by a novel energy restriction-mimetic agent.Carcinogenesis2013 DecChu PCdoi: 10.1093/carcin/bgt251
26362209The first echinoderm poly-U-binding factor 60 kDa (PUF60) from sea cucumber (Stichopus monotuberculatus): Molecular characterization, inducible expression and involvement of apoptosis.Fish Shellfish Immunol2015 NovRen Cdoi: 10.1016/j.fsi.2015.09.001
30356856The RNA-Recognition Motifs of TAR DNA-Binding Protein 43 May Play a Role in the Aberrant Self-Assembly of the Protein.Front Mol Neurosci2018 Oct 9Zacco Edoi: 10.3389/fnmol.2018.00372
31169309Long noncoding RNA LINC00958 regulates cell sensitivity to radiotherapy through RRM2 by binding to microRNA-5095 in cervical cancer.J Cell Physiol2019 Jun 6Zhao Hdoi: 10.1002/jcp.28902
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000498343RRM2-210560--- (aa)--
ENST00000485717RRM2-207573--- (aa)--
ENST00000607140RRM2-211332--- (aa)--
ENST00000641198RRM2-2133431-ENSP00000493399389 (aa)-P31350
ENST00000474701RRM2-2061060-ENSP00000419177289 (aa)-C9JXC1
ENST00000462343RRM2-205454--- (aa)--
ENST00000487591RRM2-208592--- (aa)--
ENST00000491447RRM2-209644--- (aa)--
ENST00000459969RRM2-203787--- (aa)--
ENST00000304567RRM2-2013271-ENSP00000302955389 (aa)-P31350
ENST00000461327RRM2-204580--- (aa)--
ENST00000360566RRM2-2023673-ENSP00000353770449 (aa)-P31350
ENST00000615152RRM2-2123434-ENSP00000484183449 (aa)-P31350
Gene Model
Click here to download ENSG00000171848's gene model file
Pathways
Pathway IDPathway NameSource
hsa00230Purine metabolismKEGG
hsa00240Pyrimidine metabolismKEGG
hsa00480Glutathione metabolismKEGG
hsa00983Drug metabolism - other enzymesKEGG
hsa01100Metabolic pathwaysKEGG
hsa04115p53 signaling pathwayKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000171848Platelet Function Tests1.2338300E-005-
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000171848's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000171848RRM29469.597YJL026WRNR28268.712Saccharomyces_cerevisiae
ENSG00000171848RRM29449.265YGR180CRNR49448.148Saccharomyces_cerevisiae
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle-TASProcess
GO:0004748ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor21873635.IBAFunction
GO:0004748ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor-ISSFunction
GO:0004748ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor1627826.NASFunction
GO:0005515protein binding17726094.21336276.22632967.IPIFunction
GO:0005829cytosol21873635.IBAComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0005971ribonucleoside-diphosphate reductase complex-IEAComponent
GO:0006260DNA replication-IEAProcess
GO:0008199ferric iron binding-IEAFunction
GO:0009263deoxyribonucleotide biosynthetic process21873635.IBAProcess
GO:0009263deoxyribonucleotide biosynthetic process-ISSProcess
GO:0015949nucleobase-containing small molecule interconversion-TASProcess
GO:0042803protein homodimerization activity-IEAFunction
GO:0051290protein heterotetramerization-IEAProcess
GO:0055114oxidation-reduction process-IEAProcess
GO:0070317negative regulation of G0 to G1 transition-TASProcess
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us