EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
29335436	Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism.	Nat Commun	2018 Jan 15	Chen M	doi: 10.1038/s41467-017-02272-y.
24574500	Identification of two forms of TNF tolerance in human monocytes: differential inhibition of NF-??B/AP-1- and PP1-associated signaling.	J Immunol	2014 Apr 1	G??nther J	doi: 10.4049/jimmunol.1301610
26033480	Inflammation-induced radioresistance is mediated by ROS-dependent inactivation of protein phosphatase 1 in non-small cell lung cancer cells.	Apoptosis	2015 Sep	Kim W	doi: 10.1007/s10495-015-1141-1.
21106093	Prediction and diagnosis of bladder cancer recurrence based on urinary content of hTERT, SENP1, PPP1CA, and MCM5 transcripts.	BMC Cancer	2010 Nov 24	Brems-Eskildsen AS	doi: 10.1186/1471-2407-10-646.
23176181	PP-1α and PP-1γ display antagonism and differential roles in tumorigenicity of lung cancer cells.	Curr Mol Med	2013 Jan	Chen PC	-
26636645	Protein phosphatase 1 suppresses androgen receptor ubiquitylation and degradation.	Oncotarget	2016 Jan 12	Liu X	doi: 10.18632/oncotarget.6434.
29187447	Analysis of Autoantibodies Related to Tumor Progression in Sera from Patients with High-grade Non-muscle-invasive Bladder Cancer.	Anticancer Res	2017 Dec	Minami S	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr11	67399107	Missense_Mutation	NA	D194N	0.23
BLCA	chr11	67401188	Missense_Mutation	novel	R23W	0.22
BLCA	chr11	67398950	Missense_Mutation	rs772793107	R246Q	0.13
BLCA	chr11	67400738	Silent	novel	G123G	0.15
BLCA	chr11	67399616	Missense_Mutation	novel	F156L	0.2
BLCA	chr11	67401139	Missense_Mutation	novel	C39Y	0.14
BLCA	chr11	67400729	Missense_Mutation	NA	E126D	0.15
BRCA	chr11	67401116	Silent	NA	L47L	0.31
BRCA	chr11	67399108	Silent	NA	T193T	0.5
CESC	chr11	67399585	Missense_Mutation	novel	E167K	0.11
CESC	chr11	67400717	Silent	NA	I130I	0.38
CESC	chr11	67398447	3'UTR	novel		0.2
CESC	chr11	67400753	Silent	rs748972777	F118F	0.2
CHOL	chr11	67400817	Missense_Mutation	NA	G97D	0.12
COAD	chr11	67400699	Missense_Mutation	novel	F136L	0.4
COAD	chr11	67398789	Missense_Mutation	NA	Y272C	0.3
COAD	chr11	67398528	3'UTR	rs17880251		0.36
COAD	chr11	67398725	Silent	NA	F293F	0.37
COAD	chr11	67399656	Missense_Mutation	NA	R143H	0.18
COAD	chr11	67401264	Intron	novel		0.41
COAD	chr11	67398613	Silent	NA	K305K	0.18
COAD	chr11	67398646	Splice_Site	novel	X295_splice	0.13
DLBC	chr11	67400853	Missense_Mutation	novel	S85T	0.21
DLBC	chr11	67401448	Intron	novel		0.57
ESCA	chr11	67400692	Nonsense_Mutation	novel	E139*	0.16
GBM	chr11	67401206	Splice_Region	novel		0.4
GBM	chr11	67398464	3'UTR	novel		0.33
HNSC	chr11	67398522	3'UTR	novel		0.25
HNSC	chr11	67399575	Missense_Mutation	rs760799660	F170C	0.12
KIRP	chr11	67401117	Silent	novel	F46F	0.27
LIHC	chr11	67398812	Silent	novel	V264V	0.42
LIHC	chr11	67398754	Missense_Mutation	NA	S284G	0.07
LIHC	chr11	67398617	Frame_Shift_Del	novel	*K301Rfs9**	0.16
LUAD	chr11	67399152	Frame_Shift_Del	novel	*D179Tfs73**	0.16
LUAD	chr11	67401106	Missense_Mutation	NA	P50H	0.29
LUSC	chr11	67398605	Missense_Mutation	novel	Q308L	0.23
LUSC	chr11	67401235	Intron	novel		0.1
LUSC	chr11	67401146	Missense_Mutation	NA	G37C	0.44
LUSC	chr11	67401080	Missense_Mutation	novel	L59I	0.13
LUSC	chr11	67400798	Silent	novel	T103T	0.09
LUSC	chr11	67399040	Nonsense_Mutation	novel	W216*	0.39
LUSC	chr11	67401237	Intron	novel		0.31
MESO	chr11	67401568	Intron	novel		0.4
MESO	chr11	67400816	In_Frame_Del	novel	E77_G97del	0.12
OV	chr11	67400751	Missense_Mutation	novel	F119C	0.05
OV	chr11	67399004	In_Frame_Ins	novel	G228delinsAQDFRKEQVMR	0.23
PAAD	chr11	67398633	Missense_Mutation	rs773623660	A299T	0.18
PRAD	chr11	67399644	Missense_Mutation	NA	K147I	0.15
SARC	chr11	67401017	Intron	novel		0.83
SKCM	chr11	67399585	Nonsense_Mutation	NA	E167*	0.37
SKCM	chr11	67399029	Missense_Mutation	NA	D220N	0.21
SKCM	chr11	67399035	Missense_Mutation	NA	E218K	0.43
SKCM	chr11	67398545	Missense_Mutation	novel	A328V	0.29
STAD	chr11	67399114	Silent	novel	R191R	0.22
STAD	chr11	67398437	3'UTR	novel		0.71
STAD	chr11	67401200	Splice_Site	NA	X19_splice	0.25
STAD	chr11	67400697	Missense_Mutation	NA	Y137C	0.15
UCEC	chr11	67401194	Missense_Mutation	NA	G21C	0.24
UCEC	chr11	67399644	Missense_Mutation	novel	K147T	0.37
UCEC	chr11	67398560	Missense_Mutation	rs766862399	R323H	0.41
UCEC	chr11	67398630	Missense_Mutation	rs774510465	D300N	0.09
UCEC	chr11	67400810	Silent	novel	Q99Q	0.42
UCEC	chr11	67398552	Missense_Mutation	rs140048086	A326T	0.26
UCEC	chr11	67398414	3'UTR	novel		0.51
UCEC	chr11	67400753	Missense_Mutation	novel	F118L	0.38
UCEC	chr11	67398776	Silent	novel	F276F	0.27
UCEC	chr11	67400817	Missense_Mutation	NA	G97D	0.25
UCEC	chr11	67401200	Splice_Site	NA	X19_splice	0.23
UCEC	chr11	67399585	Missense_Mutation	novel	E167K	0.47
UCEC	chr11	67399050	Missense_Mutation	novel	V213M	0.41
UCEC	chr11	67401324	Intron	novel		0.3
UCEC	chr11	67400759	Missense_Mutation	NA	E116D	0.4
UCEC	chr11	67400761	Missense_Mutation	novel	E116K	0.53

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ESCA	AMP	0.2772	0.018342
PRAD	AMP	0.0711	1.1386e-05
TGCT	DEL	0.7133	0.21504

Survival Analysis

Cancer	P-value	Q-value
THYM	0.013	Kaplan-Meier Survival Analysis
MESO	0.019	Kaplan-Meier Survival Analysis
ACC	0.00015	Kaplan-Meier Survival Analysis
PAAD	0.013	Kaplan-Meier Survival Analysis
PCPG	0.041	Kaplan-Meier Survival Analysis
CESC	0.014	Kaplan-Meier Survival Analysis
LAML	0.00031	Kaplan-Meier Survival Analysis
LIHC	0.0015	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
THCA	0.0044	Kaplan-Meier Survival Analysis
UVM	0.0097	Kaplan-Meier Survival Analysis
OV	0.042	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000172531 (Gene tree)
Gene ID: 5499
Gene Symbol: PPP1CA
Alias: PP1A|PP-1A|PP1alpha|PPP1A
Full Name: protein phosphatase 1 catalytic subunit alpha
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 23,003 bases
Position: chr11:67,398,181-67,421,183
Accession: 9281
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000529724	PPP1CA-206	572	-	-	- (aa)	-	-
ENST00000358239	PPP1CA-202	1054	-	ENSP00000350974	286 (aa)	-	P62136
ENST00000526510	PPP1CA-204	1677	-	-	- (aa)	-	-
ENST00000312989	PPP1CA-201	1389	-	ENSP00000326031	341 (aa)	-	P62136
ENST00000537694	PPP1CA-209	882	-	-	- (aa)	-	-
ENST00000546202	PPP1CA-211	554	-	ENSP00000439568	169 (aa)	-	F5H1L6
ENST00000527663	PPP1CA-205	765	-	ENSP00000431146	253 (aa)	-	E9PMD7
ENST00000532279	PPP1CA-207	552	-	-	- (aa)	-	-
ENST00000542876	PPP1CA-210	588	-	ENSP00000438409	179 (aa)	-	F5H037
ENST00000376745	PPP1CA-203	1476	-	ENSP00000365936	330 (aa)	-	P62136
ENST00000532446	PPP1CA-208	1465	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000172531's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03015	mRNA surveillance pathway	KEGG
hsa04022	cGMP-PKG signaling pathway	KEGG
hsa04024	cAMP signaling pathway	KEGG
hsa04114	Oocyte meiosis	KEGG
hsa04218	Cellular senescence	KEGG
hsa04261	Adrenergic signaling in cardiomyocytes	KEGG
hsa04270	Vascular smooth muscle contraction	KEGG
hsa04390	Hippo signaling pathway	KEGG
hsa04510	Focal adhesion	KEGG
hsa04611	Platelet activation	KEGG
hsa04720	Long-term potentiation	KEGG
hsa04728	Dopaminergic synapse	KEGG
hsa04750	Inflammatory mediator regulation of TRP channels	KEGG
hsa04810	Regulation of actin cytoskeleton	KEGG
hsa04910	Insulin signaling pathway	KEGG
hsa04921	Oxytocin signaling pathway	KEGG
hsa04931	Insulin resistance	KEGG
hsa05031	Amphetamine addiction	KEGG
hsa05034	Alcoholism	KEGG
hsa05168	Herpes simplex virus 1 infection	KEGG
hsa05205	Proteoglycans in cancer	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000172531	rs61734601	11	67417254	A	Height	28270201	[0.0054-0.0102] m decrease	0.007811173	EFO_0004339

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000172531's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000172531	PPP1CA	90	93.603	FBgn0004103	Pp1-87B	98	93.603	Drosophila_melanogaster
ENSG00000172531	PPP1CA	100	90.663	ENSG00000186298	PPP1CC	100	94.286	Homo_sapiens
ENSG00000172531	PPP1CA	100	99.697	ENSMUSG00000040385	Ppp1ca	100	99.697	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000164	protein phosphatase type 1 complex	-	IEA	Component
GO:0000784	nuclear chromosome, telomeric region	24270157.	IDA	Component
GO:0004721	phosphoprotein phosphatase activity	-	ISS	Function
GO:0004722	protein serine/threonine phosphatase activity	21873635.	IBA	Function
GO:0004722	protein serine/threonine phosphatase activity	10640627.16262633.	TAS	Function
GO:0005515	protein binding	10807923.11739654.12434308.15231748.16263087.16732323.17274640.17318175.17511879.17965019.18068675.18842582.19389623.20186153.20305656.20424263.20467437.20516061.20826336.20926688.21094159.21382349.21518769.21666598.21998301.22321011.22365833.22940584.23396208.23555304.23937259.24366813.25416956.25544563.25593058.25785436.27173435.28330616.29109149.	IPI	Function
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	11739654.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005730	nucleolus	-	IEA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	11739654.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0005913	cell-cell adherens junction	25468996.	IDA	Component
GO:0005977	glycogen metabolic process	-	IEA	Process
GO:0005979	regulation of glycogen biosynthetic process	-	IEA	Process
GO:0005981	regulation of glycogen catabolic process	-	IEA	Process
GO:0006470	protein dephosphorylation	22311981.22801782.	IMP	Process
GO:0006470	protein dephosphorylation	-	ISS	Process
GO:0007049	cell cycle	-	IEA	Process
GO:0008157	protein phosphatase 1 binding	21873635.	IBA	Function
GO:0010288	response to lead ion	-	ISS	Process
GO:0016311	dephosphorylation	22311981.	IDA	Process
GO:0016791	phosphatase activity	-	ISS	Function
GO:0030324	lung development	-	IEA	Process
GO:0032091	negative regulation of protein binding	-	ISS	Process
GO:0032922	circadian regulation of gene expression	-	ISS	Process
GO:0035970	peptidyl-threonine dephosphorylation	16262633.	TAS	Process
GO:0036496	regulation of translational initiation by eIF2 alpha dephosphorylation	-	ISS	Process
GO:0042587	glycogen granule	-	IEA	Component
GO:0042752	regulation of circadian rhythm	21873635.	IBA	Process
GO:0042752	regulation of circadian rhythm	21712997.	IMP	Process
GO:0043021	ribonucleoprotein complex binding	-	IEA	Function
GO:0043153	entrainment of circadian clock by photoperiod	21873635.	IBA	Process
GO:0043153	entrainment of circadian clock by photoperiod	-	ISS	Process
GO:0043197	dendritic spine	-	IEA	Component
GO:0043204	perikaryon	-	IEA	Component
GO:0046872	metal ion binding	-	IEA	Function
GO:0048754	branching morphogenesis of an epithelial tube	-	IEA	Process
GO:0051301	cell division	-	IEA	Process
GO:0060828	regulation of canonical Wnt signaling pathway	17318175.	IC	Process
GO:0070062	extracellular exosome	20458337.	HDA	Component
GO:0070262	peptidyl-serine dephosphorylation	16262633.	TAS	Process
GO:0072357	PTW/PP1 phosphatase complex	20516061.	IDA	Component
GO:0098609	cell-cell adhesion	-	IEA	Process
GO:0098641	cadherin binding involved in cell-cell adhesion	25468996.	IDA	Function
GO:0098793	presynapse	-	IEA	Component
GO:0098978	glutamatergic synapse	-	IEA	Component
GO:1904886	beta-catenin destruction complex disassembly	-	ISS	Process
GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.