EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23320827	CFL1 and Arp3 are biomarkers for metastasis and poor prognosis of squamous cell/adenosquamous carcinomas and adenocarcinomas of gallbladder.	Cancer Invest	2013 Feb	Yang ZL	doi: 10.3109/07357907.2012.756113
21045147	The mitotic kinase Aurora-A induces mammary cell migration and breast cancer metastasis by activating the Cofilin-F-actin pathway.	Cancer Res	2010 Nov 15	Wang LH	doi: 10.1158/0008-5472.CAN-10-1246
18987670	Plexin C1, a receptor for semaphorin 7a, inactivates cofilin and is a potential tumor suppressor for melanoma progression.	J Invest Dermatol	2009 Apr	Scott GA	doi: 10.1038/jid.2008.329
22742733	Over-expression of cofilin-1 and phosphoglycerate kinase 1 in astrocytomas involved in pathogenesis of radioresistance.	CNS Neurosci Ther	2012 Sep	Yan H	doi: 10.1111/j.1755-5949.2012.00353.x
24106833	Identification of stage-specific breast markers using quantitative proteomics.	J Proteome Res	2013 Dec 6	Shaheed SU	doi: 10.1021/pr400662k
28826686	Cofilin is a cAMP effector in mediating actin cytoskeleton reorganization and steroidogenesis in mouse and human adrenocortical tumor cells.	Cancer Lett	2017 Oct 10	Peverelli E	doi: 10.1016/j.canlet.2017.07.025
27035282	Anticancer effect of docetaxel induces apoptosis of prostate cancer via the cofilin-1 and paxillin signaling pathway.	Mol Med Rep	2016 May	Xiao P	doi: 10.3892/mmr.2016.5000
27402302	Association of epithelial-mesenchymal transition and nuclear cofilin with advanced urothelial cancer.	Hum Pathol	2016 Nov	Hensley PJ	doi: 10.1016/j.humpath.2016.06.020
20133759	HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1.	Proc Natl Acad Sci U S A	2010 Feb 9	Quintela-Fandino M	doi: 10.1073/pnas.0914492107
21735353	Validation of cofilin-1 as a biomarker in non-small cell lung cancer: application of quantitative method in a retrospective cohort.	J Cancer Res Clin Oncol	2011 Sep	M??ller CB	doi: 10.1007/s00432-011-1001-5
20564088	CFL1 expression levels as a prognostic and drug resistance marker in nonsmall cell lung cancer.	Cancer	2010 Aug 1	Castro MA	doi: 10.1002/cncr.25125.
20819441	Expression of the actin-binding proteins indicates that cofilin and fascin are related to breast tumour size.	J Int Med Res	2010 May-Jun	Zhang Y	-
21894436	Differential expression of up-regulated cofilin-1 and down-regulated cofilin-2 characteristic of pancreatic cancer tissues.	Oncol Rep	2011 Dec	Wang Y	doi: 10.3892/or.2011.1447
26058485	MicroRNA-429 inhibits the migration and invasion of colon cancer cells by targeting PAK6/cofilin signaling.	Oncol Rep	2015 Aug	Tian X	doi: 10.3892/or.2015.4039
23064469	Upregulation of phosphorylated cofilin 1 correlates with taxol resistance in human ovarian cancer in vitro and in vivo.	Oncol Rep	2013 Jan	Li M	doi: 10.3892/or.2012.2078
17583572	Differential involvement of destrin and cofilin-1 in the control of invasive properties of Isreco1 human colon cancer cells.	Int J Cancer	2007 Nov 15	Estornes Y	-
16301112	Inhibition of invasiveness of human lung cancer cell line H1299 by over-expression of cofilin.	Cell Biol Int	2005 Nov	Lee YJ	-
27003257	Aurora kinase A induces papillary thyroid cancer lymph node metastasis by promoting cofilin-1 activity.	Biochem Biophys Res Commun	2016 Apr 22	Maimaiti Y	doi: 10.1016/j.bbrc.2016.03.081
21237490	Overexpression of cofilin 1 can predict progression-free survival in patients with epithelial ovarian cancer receiving standard therapy.	Hum Pathol	2011 Apr	Nishimura S	doi: 10.1016/j.humpath.2010.07.019
27665963	MicroRNA-138 inhibits migration and invasion of non-small cell lung cancer cells by targeting LIMK1.	Mol Med Rep	2016 Nov	Tan Y	doi: 10.3892/mmr.2016.5769
27768223	Study on the significance of Cofilin 1 overexpression in human bladder cancer.	Tumori	2017 Nov 23	Wang F	doi: 10.5301/tj.5000569
27626171	CD74 interacts with CD44 and enhances tumorigenesis and metastasis via RHOA-mediated cofilin phosphorylation in human breast cancer cells.	Oncotarget	2016 Oct 18	Liu Z	doi: 10.18632/oncotarget.11945.
28440035	MiR-145 inhibits human colorectal cancer cell migration and invasion via PAK4-dependent pathway.	Cancer Med	2017 Jun	Sheng N	doi: 10.1002/cam4.1029
28446539	Transient mechanical strain promotes the maturation of invadopodia and enhances cancer cell invasion in vitro.	J Cell Sci	2017 Jun 1	Gasparski AN	doi: 10.1242/jcs.199760
28388575	Cofilin 1 induces the epithelial-mesenchymal transition of gastric cancer cells by promoting cytoskeletal rearrangement.	Oncotarget	2017 Jun 13	Wang H	doi: 10.18632/oncotarget.16608.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr11	65855972	Missense_Mutation	novel	K92E	0.16
BLCA	chr11	65855706	Silent	NA	K112K	0.19
BLCA	chr11	65856159	Silent	novel	V29V	0.15
BLCA	chr11	65856147	Silent	novel	K33K	0.55
BLCA	chr11	65856006	Silent	rs371721199	C80C	0.3
BLCA	chr11	65856141	Silent	rs762181259	A35A	0.15
BRCA	chr11	65856236	Nonsense_Mutation	novel	S3_G4ins*	0.25
BRCA	chr11	65858263	5'UTR	novel		0.41
BRCA	chr11	65855609	Intron	novel		0.36
CESC	chr11	65854983	3'UTR	novel		0.46
CESC	chr11	65858263	5'UTR	novel		0.64
CESC	chr11	65856221	Missense_Mutation	novel	D9N	0.44
COAD	chr11	65855365	Missense_Mutation	NA	V158I	0.12
COAD	chr11	65856243	Splice_Site	NA	X2_splice	0.4
COAD	chr11	65855457	Intron	novel		0.4
COAD	chr11	65856151	Missense_Mutation	novel	R32H	0.19
COAD	chr11	65855903	Intron	NA		0.41
COAD	chr11	65855497	Intron	novel		0.19
COAD	chr11	65855829	Intron	novel		0.12
DLBC	chr11	65855568	Intron	novel		0.11
DLBC	chr11	65858106	5'UTR	novel		0.25
ESCA	chr11	65858469	5'Flank	novel		0.5
ESCA	chr11	65855042	3'UTR	novel		0.43
ESCA	chr11	65856244	Splice_Site	novel	X2_splice	0.27
GBM	chr11	65855365	Missense_Mutation	NA	V158I	0.64
GBM	chr11	65856031	Missense_Mutation	novel	V72A	0.46
GBM	chr11	65855674	Missense_Mutation	novel	A123D	0.14
HNSC	chr11	65856053	Missense_Mutation	novel	D65N	0.4
HNSC	chr11	65856122	Missense_Mutation	novel	E42K	0.26
HNSC	chr11	65855561	Intron	novel		0.14
HNSC	chr11	65855724	Silent	rs776644270	P106P	0.15
KIRC	chr11	65855262	3'UTR	novel		0.32
KIRC	chr11	65855740	Intron	novel		0.31
KIRC	chr11	65855392	Frame_Shift_Del	novel	*L149Wfs81**	0.36
KIRP	chr11	65855219	3'UTR	novel		0.11
LGG	chr11	65855731	Splice_Site	NA	X104_splice	0.06
LGG	chr11	65855906	Intron	novel		0.4
LIHC	chr11	65855588	Intron	novel		0.41
LIHC	chr11	65856194	Missense_Mutation	NA	M18L	0.38
LIHC	chr11	65855831	Intron	novel		0.1
LUSC	chr11	65856018	Silent	novel	P76P	0.25
LUSC	chr11	65855447	Splice_Region	rs200515388	G130G	0.38
LUSC	chr11	65856019	Missense_Mutation	NA	P76L	0.11
LUSC	chr11	65855797	Intron	novel		0.38
LUSC	chr11	65855385	Missense_Mutation	NA	E151V	0.55
OV	chr11	65855424	Missense_Mutation	novel	N138I	0.19
OV	chr11	65855912	Intron	novel		0.04
OV	chr11	65855527	Intron	novel		0.13
OV	chr11	65855528	Intron	novel		0.13
OV	chr11	65855593	Intron	novel		0.21
PRAD	chr11	65856033	Frame_Shift_Del	novel	*F71Lfs45**	0.14
SKCM	chr11	65855357	Silent	rs760995765	S160S	0.66
SKCM	chr11	65855539	Intron	novel		0.18
SKCM	chr11	65855253	3'UTR	novel		0.65
SKCM	chr11	65855561	Intron	novel		0.54
SKCM	chr11	65855715	Silent	rs373497422	A109A	0.32
SKCM	chr11	65855711	Missense_Mutation	NA	L111F	0.48
SKCM	chr11	65855266	3'UTR	novel		0.57
SKCM	chr11	65856002	Missense_Mutation	novel	Y82H	0.5
SKCM	chr11	65855683	Missense_Mutation	novel	S120F	0.48
STAD	chr11	65855373	Frame_Shift_Del	novel	*G155Afs75**	0.13
STAD	chr11	65856140	Missense_Mutation	NA	V36M	0.24
STAD	chr11	65855501	Intron	novel		0.33
UCEC	chr11	65855999	Missense_Mutation	NA	A83T	0.2
UCEC	chr11	65855399	Silent	NA	R146R	0.47
UCEC	chr11	65856063	Silent	novel	G61G	0.06
UCEC	chr11	65856141	Silent	rs762181259	A35A	0.29
UCEC	chr11	65854876	3'UTR	novel		0.48
UCEC	chr11	65855042	3'UTR	novel		0.5
UCEC	chr11	65855223	3'UTR	novel		0.57
UCEC	chr11	65856142	Missense_Mutation	novel	A35V	0.38
UCEC	chr11	65858351	5'Flank	novel		0.67
UCEC	chr11	65855706	Missense_Mutation	novel	K112N	0.21
UCEC	chr11	65856152	Missense_Mutation	novel	R32C	0.32
UCEC	chr11	65855715	Silent	rs373497422	A109A	0.2
UCEC	chr11	65858137	5'UTR	novel		0.82
UCEC	chr11	65855596	Intron	novel		0.22
UCEC	chr11	65856054	Silent	rs11550148	V64V	0.48

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BRCA	DEL	0.1694	1.2183e-05
ESCA	AMP	0.212	0.018342
TGCT	DEL	0.7	0.21504

Survival Analysis

Cancer	P-value	Q-value
THYM	0.04	Kaplan-Meier Survival Analysis
KIRC	0.0039	Kaplan-Meier Survival Analysis
STAD	0.027	Kaplan-Meier Survival Analysis
MESO	0.0001	Kaplan-Meier Survival Analysis
ACC	0.0031	Kaplan-Meier Survival Analysis
HNSC	0.0068	Kaplan-Meier Survival Analysis
COAD	0.0069	Kaplan-Meier Survival Analysis
PAAD	0.041	Kaplan-Meier Survival Analysis
LAML	0.0001	Kaplan-Meier Survival Analysis
UCEC	0.02	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.00052	Kaplan-Meier Survival Analysis
UVM	0.019	Kaplan-Meier Survival Analysis
OV	0.0088	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000172757 (Gene tree)
Gene ID: 1072
Gene Symbol: CFL1
Alias: CFL
Full Name: cofilin 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 39,005 bases
Position: chr11:65,823,022-65,862,026
Accession: 1874
RBP type: non-canonical RBP
Summary: The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
27838743	Intrinsic disorder in proteins involved in amyotrophic lateral sclerosis.	Cell Mol Life Sci	2017 Apr	Santamaria N	doi: 10.1007/s00018-016-2416-6
12833515	Proteome analysis of dermal fibroblasts cultured in vitro from human healthy subjects of different ages.	Proteomics	2003 Jun	Boraldi F	-
15545320	The RNA-binding protein SUP-12 controls muscle-specific splicing of the ADF/cofilin pre-mRNA in C. elegans.	J Cell Biol	2004 Nov 22	Anyanful A	-
28216224	Targeted proteomics driven verification of biomarker candidates associated with breast cancer aggressiveness.	Biochim Biophys Acta Proteins Proteom	2017 May	Prochazkova I	doi: 10.1016/j.bbapap.2017.02.012
25908858	Localization of cofilin mRNA to the leading edge of migrating cells promotes directed cell migration.	J Cell Sci	2015 May 15	Maizels Y	doi: 10.1242/jcs.163972
20978191	mTOR complex component Rictor interacts with PKCzeta and regulates cancer cell metastasis.	Cancer Res	2010 Nov 15	Zhang F	doi: 10.1158/0008-5472.CAN-10-0207
30175261	Leucine modulates the IPEC-J2 cell proteome associated with cell proliferation, metabolism and phagocytosis.	Anim Nutr	2018 Sep	Mao X	doi: 10.1016/j.aninu.2018.03.006

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000527344	CFL1-206	962	-	ENSP00000432155	149 (aa)	-	G3V1A4
ENST00000531413	CFL1-212	636	-	ENSP00000433131	149 (aa)	-	G3V1A4
ENST00000308162	CFL1-201	1234	-	ENSP00000309629	166 (aa)	-	P23528
ENST00000525710	CFL1-204	761	-	-	- (aa)	-	-
ENST00000531407	CFL1-211	1062	-	ENSP00000433910	149 (aa)	-	G3V1A4
ENST00000530945	CFL1-210	1509	-	-	- (aa)	-	-
ENST00000530157	CFL1-208	1082	-	-	- (aa)	-	-
ENST00000525451	CFL1-203	1878	-	ENSP00000432660	166 (aa)	-	P23528
ENST00000534769	CFL1-214	758	-	ENSP00000431696	204 (aa)	-	E9PK25
ENST00000527752	CFL1-207	766	-	-	- (aa)	-	-
ENST00000524553	CFL1-202	860	-	ENSP00000432226	149 (aa)	-	G3V1A4
ENST00000532134	CFL1-213	855	-	ENSP00000436431	159 (aa)	-	E9PP50
ENST00000530413	CFL1-209	647	-	ENSP00000436899	122 (aa)	-	E9PQB7
ENST00000534784	CFL1-215	737	-	ENSP00000433308	79 (aa)	-	E9PLJ3
ENST00000526975	CFL1-205	567	-	ENSP00000432153	90 (aa)	-	E9PS23

Gene Model

Click here to download ENSG00000172757's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04360	Axon guidance	KEGG
hsa04666	Fc gamma R-mediated phagocytosis	KEGG
hsa04810	Regulation of actin cytoskeleton	KEGG
hsa05133	Pertussis	KEGG
hsa05170	Human immunodeficiency virus 1 infection	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000172757	rs77779142	11	65832185	T	Rosacea symptom severity	29771307	[0.098-0.201] unit increase	0.149773	EFO_0009180
ENSG00000172757	rs77291001	11	65837328	G	Maximum cranial width	29698431	[-0.48418-1.61538] unit increase	0.5656	EFO_0009278
ENSG00000172757	rs118086960	11	65825973	T	Psoriasis	28537254		1.12	EFO_0000676
ENSG00000172757	rs11602769	11	65826668	C	Allergic sensitization	30013184	[1.07-1.17]	1.12	EFO_0005298
ENSG00000172757	rs17854357	11	65834089	?	Menarche (age at onset)	30595370			EFO_0004703

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000172757's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000172757	CFL1	97	30.588	WBGene00006794	unc-60	96	30.588	Caenorhabditis_elegans
ENSG00000172757	CFL1	94	35.659	FBgn0011726	tsr	86	36.842	Drosophila_melanogaster
ENSG00000172757	CFL1	100	98.889	ENSMUSG00000056201	Cfl1	100	98.795	Mus_musculus
ENSG00000172757	CFL1	98	35.227	YLL050C	COF1	87	37.762	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000281	mitotic cytokinesis	-	IEA	Process
GO:0001755	neural crest cell migration	-	IEA	Process
GO:0001842	neural fold formation	-	IEA	Process
GO:0005102	signaling receptor binding	-	IEA	Function
GO:0005515	protein binding	12361576.15161933.15846844.16189514.16713569.17853892.19424295.20133759.21525957.25416956.25556234.	IPI	Function
GO:0005615	extracellular space	23580065.	HDA	Component
GO:0005634	nucleus	16130169.	TAS	Component
GO:0005737	cytoplasm	25556234.	IDA	Component
GO:0005737	cytoplasm	16130169.	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005911	cell-cell junction	-	IEA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0005925	focal adhesion	29162887.	IDA	Component
GO:0006468	protein phosphorylation	-	IEA	Process
GO:0007010	cytoskeleton organization	21834987.	IMP	Process
GO:0007266	Rho protein signal transduction	10436159.	TAS	Process
GO:0009615	response to virus	16548883.	IEP	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016363	nuclear matrix	-	IEA	Component
GO:0022604	regulation of cell morphogenesis	21834987.	IMP	Process
GO:0030010	establishment of cell polarity	-	IEA	Process
GO:0030027	lamellipodium	-	ISS	Component
GO:0030036	actin cytoskeleton organization	10436159.	TAS	Process
GO:0030042	actin filament depolymerization	11812157.	IDA	Process
GO:0030042	actin filament depolymerization	24052308.	NAS	Process
GO:0030043	actin filament fragmentation	-	IEA	Process
GO:0030836	positive regulation of actin filament depolymerization	-	IEA	Process
GO:0030864	cortical actin cytoskeleton	-	IEA	Component
GO:0031258	lamellipodium membrane	-	IEA	Component
GO:0031982	vesicle	19190083.	HDA	Component
GO:0032587	ruffle membrane	-	IEA	Component
GO:0035722	interleukin-12-mediated signaling pathway	-	TAS	Process
GO:0043066	negative regulation of apoptotic process	16130169.	TAS	Process
GO:0043200	response to amino acid	-	IEA	Process
GO:0044794	positive regulation by host of viral process	25556234.	IMP	Process
GO:0051015	actin filament binding	11812157.	IDA	Function
GO:0051015	actin filament binding	-	ISS	Function
GO:0061001	regulation of dendritic spine morphogenesis	24464040.	IMP	Process
GO:0070062	extracellular exosome	19199708.20458337.23533145.	HDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.