EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
19846935	Down-regulation of Tip60 gene as a potential marker for the malignancy of colorectal cancer.	Anticancer Res	2009 Oct	Sakuraba K	-
26464124	Tip60 regulates MT1-MMP transcription and invasion of glioblastoma cells through NF-κB pathway.	Clin Exp Metastasis	2016 Jan	Takino T	-
29174981	Acetylation of TIP60 at K104 is essential for metabolic stress-induced apoptosis in cells of hepatocellular cancer.	Exp Cell Res	2018 Jan 15	Fang X	doi: 10.1016/j.yexcr.2017.11.028
26234678	E3 ligase EDD1/UBR5 is utilized by the HPV E6 oncogene to destabilize tumor suppressor TIP60.	Oncogene	2016 Apr 21	Subbaiah VK	doi: 10.1038/onc.2015.268
19938016	Tip60 promotes prostate cancer cell proliferation by translocation of androgen receptor into the nucleus.	Prostate	2010 Apr 1	Shiota M	doi: 10.1002/pros.21088.
21574959	PLU1 histone demethylase decreases the expression of KAT5 and enhances the invasive activity of the cells.	Biochem J	2011 Aug 1	Yoshida M	doi: 10.1042/BJ20110343.
24294372	KAT5 and KAT6B are in positive regulation on cell proliferation of prostate cancer through PI3K-AKT signaling.	Int J Clin Exp Pathol	2013 Nov 15	He W	-
26512777	TIP60-miR-22 axis as a prognostic marker of breast cancer progression.	Oncotarget	2015 Dec 1	Pandey AK	doi: 10.18632/oncotarget.5636.
23056207	Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer.	PLoS One	2012	Coffey K	doi: 10.1371/journal.pone.0045539
19169279	The p400/Tip60 ratio is critical for colorectal cancer cell proliferation through DNA damage response pathways.	Oncogene	2009 Mar 26	Mattera L	doi: 10.1038/onc.2008.499
19783983	Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60.	Nat Cell Biol	2009 Nov	Sun Y	doi: 10.1038/ncb1982
29045464	TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter.	PLoS Pathog	2017 Oct 18	Rajagopalan D	doi: 10.1371/journal.ppat.1006681
28873018	TIP60 Histone Acetyltransferase in Adipose Tissue: Possible Linkages with Breast Cancer Development?	OMICS	2017 Nov	Judes G	doi: 10.1089/omi.2017.0117
30142696	Elevation of androgen receptor promotes prostate cancer metastasis by induction of epithelial-mesenchymal transition and reduction of KAT5.	Cancer Sci	2018 Nov	Lin CY	doi: 10.1111/cas.13776
30154425	TIP60-dependent acetylation of the SPZ1-TWIST complex promotes epithelial-mesenchymal transition and metastasis in liver cancer.	Oncogene	2019 Jan	Wang LT	doi: 10.1038/s41388-018-0457-z

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr11	65712297	Intron	novel		0.42
BLCA	chr11	65718933	Silent	novel	L462L	0.33
BLCA	chr11	65713597	Missense_Mutation	NA	R149Q	0.21
BLCA	chr11	65713615	Missense_Mutation	NA	S155L	0.4
BLCA	chr11	65718729	Missense_Mutation	novel	E435D	0.25
BLCA	chr11	65712645	Intron	novel		0.33
BRCA	chr11	65718636	Silent	novel	K404K	0.07
BRCA	chr11	65713649	Silent	rs768660154	P166P	0.13
BRCA	chr11	65718866	Splice_Region	novel		0.39
BRCA	chr11	65719087	Missense_Mutation	novel	G483V	0.32
BRCA	chr11	65712693	Intron	novel		0.09
BRCA	chr11	65714562	Missense_Mutation	novel	R220Q	0.22
BRCA	chr11	65712102	5'UTR	novel		0.21
BRCA	chr11	65716797	Missense_Mutation	novel	Y354S	0.08
CESC	chr11	65713615	Missense_Mutation	NA	S155L	0.38
CESC	chr11	65719121	Silent	novel	R494R	0.32
CESC	chr11	65713446	Silent	novel	G128G	0.24
CESC	chr11	65713787	Missense_Mutation	NA	R177H	0.16
CESC	chr11	65714570	Missense_Mutation	NA	D223N	0.52
CESC	chr11	65714904	Missense_Mutation	NA	K308N	0.19
CHOL	chr11	65712635	Intron	novel		0.5
COAD	chr11	65712029	5'UTR	novel		0.6
COAD	chr11	65713657	Frame_Shift_Del	novel	*Q172Rfs41**	0.35
COAD	chr11	65713820	Missense_Mutation	novel	R188Q	0.33
COAD	chr11	65712957	Missense_Mutation	novel	R62W	0.07
COAD	chr11	65713002	Missense_Mutation	NA	T77A	0.1
COAD	chr11	65712295	Intron	novel		0.13
COAD	chr11	65719079	Silent	rs773165524	I480I	0.15
COAD	chr11	65714715	Missense_Mutation	rs760709797	R271H	0.16
COAD	chr11	65716916	Missense_Mutation	novel	V367M	0.05
COAD	chr11	65719125	Missense_Mutation	rs199674306	D496N	0.41
DLBC	chr11	65712215	5'UTR	novel		0.36
ESCA	chr11	65713640	Silent	novel	E163E	0.26
ESCA	chr11	65719119	Missense_Mutation	rs753132884	R494W	0.18
GBM	chr11	65714867	Missense_Mutation	novel	K296M	0.11
GBM	chr11	65718613	Missense_Mutation	NA	G397R	0.08
GBM	chr11	65714680	Silent	rs771308702	V259V	0.43
GBM	chr11	65719119	Missense_Mutation	novel	R494G	0.18
GBM	chr11	65713638	Missense_Mutation	rs757474102	E163K	0.41
GBM	chr11	65713608	Missense_Mutation	novel	V153M	0.09
GBM	chr11	65714631	Missense_Mutation	novel	K243M	0.14
GBM	chr11	65714894	Missense_Mutation	novel	D305V	0.26
GBM	chr11	65714570	Missense_Mutation	NA	D223N	0.27
GBM	chr11	65716714	Frame_Shift_Del	novel	*H326Qfs16**	0.18
HNSC	chr11	65713604	In_Frame_Del	novel	E152del	0.19
HNSC	chr11	65712790	Missense_Mutation	novel	K35R	0.35	Tudor-knot
HNSC	chr11	65712650	Intron	novel		0.29
HNSC	chr11	65713787	Missense_Mutation	NA	R177H	0.2
HNSC	chr11	65714854	Missense_Mutation	novel	E292K	0.29
HNSC	chr11	65716949	Missense_Mutation	novel	R378C	0.23
HNSC	chr11	65718960	Splice_Region	novel		0.26
HNSC	chr11	65718935	Missense_Mutation	novel	N463T	0.28
HNSC	chr11	65714647	Silent	novel	S248S	0.16
KIRC	chr11	65713060	Splice_Site	NA	X95_splice	0.33
KIRP	chr11	65712836	Splice_Site	NA	X50_splice	0.06
KIRP	chr11	65712707	Intron	novel		0.29
LGG	chr11	65719119	Missense_Mutation	rs753132884	R494W	0.19
LGG	chr11	65714495	Missense_Mutation	novel	D198Y	0.43
LIHC	chr11	65714725	Missense_Mutation	NA	K274N	0.32
LIHC	chr11	65712237	5'UTR	novel		0.31
LUAD	chr11	65714865	Silent	NA	R295R	0.25
LUAD	chr11	65714618	Silent	novel	R239R	0.18
LUAD	chr11	65714720	Missense_Mutation	novel	L273V	0.03
LUAD	chr11	65713425	Missense_Mutation	novel	E121D	0.18
LUSC	chr11	65712639	Intron	novel		0.34
LUSC	chr11	65714837	Missense_Mutation	NA	R286L	0.27
LUSC	chr11	65713049	Silent	rs201415653	E92E	0.16
LUSC	chr11	65716789	Silent	novel	I351I	0.05
LUSC	chr11	65714646	Frame_Shift_Del	novel	*P249Rfs32**	0.24
LUSC	chr11	65713494	Silent	rs552339924	H144H	0.15
LUSC	chr11	65716975	In_Frame_Del	novel	I386_E387delinsM	0.08
OV	chr11	65716786	Missense_Mutation	novel	H350Q	0.07
OV	chr11	65714645	Frame_Shift_Ins	novel	*S248Cfs43**	0.11
OV	chr11	65714575	Missense_Mutation	novel	D224E	0.13
PAAD	chr11	65713826	Missense_Mutation	rs529240661	S190L	0.19
PRAD	chr11	65716901	Missense_Mutation	NA	T362A	0.19
READ	chr11	65712395	Missense_Mutation	novel	G10D	0.18
READ	chr11	65713645	Frame_Shift_Del	NA	*P166Rfs47**	0.19
READ	chr11	65714561	Nonsense_Mutation	novel	R220*	0.4
READ	chr11	65714617	Silent	NA	G238G	0.11
SKCM	chr11	65714870	Missense_Mutation	novel	G297D	0.48
SKCM	chr11	65713662	Missense_Mutation	novel	P171S	0.23
STAD	chr11	65714618	Missense_Mutation	novel	R239W	0.39
STAD	chr11	65712982	Frame_Shift_Ins	novel	*K72Qfs9**	0.16
STAD	chr11	65712657	Intron	novel		0.69
STAD	chr11	65712942	Frame_Shift_Ins	novel	*V58Gfs4**	0.43	Tudor-knot
STAD	chr11	65712931	Missense_Mutation	novel	R53H	0.2	Tudor-knot
STAD	chr11	65718867	Splice_Region	novel		0.37
STAD	chr11	65714524	Silent	rs554450356	P207P	0.23
STAD	chr11	65718931	Missense_Mutation	novel	L462V	0.32
THCA	chr11	65716674	Frame_Shift_Del	novel	*Q314Rfs28**	0.27
UCEC	chr11	65714864	Missense_Mutation	NA	R295H	0.33
UCEC	chr11	65713388	Missense_Mutation	NA	P109L	0.18
UCEC	chr11	65714535	Missense_Mutation	NA	R211H	0.4
UCEC	chr11	65716765	Missense_Mutation	NA	E343D	0.4
UCEC	chr11	65716891	Missense_Mutation	novel	E358D	0.07
UCEC	chr11	65714856	Missense_Mutation	NA	E292D	0.21
UCEC	chr11	65716709	Missense_Mutation	novel	D325N	0.05
UCEC	chr11	65718739	Missense_Mutation	NA	I439L	0.48
UCEC	chr11	65718904	Missense_Mutation	NA	E453K	0.38
UCEC	chr11	65718607	Missense_Mutation	NA	V395M	0.21
UCEC	chr11	65718633	Silent	novel	E403E	0.47
UCEC	chr11	65718622	Missense_Mutation	novel	G400W	0.36
UCEC	chr11	65714625	Missense_Mutation	NA	R241H	0.44
UCEC	chr11	65713441	Missense_Mutation	rs777887005	G127S	0.48
UCEC	chr11	65713461	Silent	rs767015066	P133P	0.45
UCEC	chr11	65713787	Missense_Mutation	NA	R177H	0.34
UCEC	chr11	65713039	Missense_Mutation	novel	G89D	0.31
UCEC	chr11	65714579	Missense_Mutation	rs747460009	V226I	0.39
UCEC	chr11	65716736	Missense_Mutation	novel	D334N	0.3
UCEC	chr11	65712767	Splice_Region	novel	P27P	0.38
UCEC	chr11	65714692	Silent	rs781377393	C263C	0.5
UCEC	chr11	65714534	Missense_Mutation	NA	R211C	0.1
UCEC	chr11	65716747	Silent	rs140561633	L337L	0.42
UCEC	chr11	65713461	Silent	rs767015066	P133P	0.13
UCEC	chr11	65714576	Missense_Mutation	novel	I225V	0.47
UCEC	chr11	65713503	Splice_Region	NA	T147T	0.4
UCEC	chr11	65714573	Missense_Mutation	novel	D224N	0.09
UCEC	chr11	65714621	Missense_Mutation	NA	H240Y	0.04
UCEC	chr11	65714864	Missense_Mutation	NA	R295H	0.38
UCEC	chr11	65712366	Intron	novel		0.4
UCEC	chr11	65713045	Frame_Shift_Ins	NA	*V95Rfs119**	0.2
UCEC	chr11	65714574	Missense_Mutation	novel	D224V	0.21
UCEC	chr11	65718716	Missense_Mutation	rs751428495	S431L	0.21
UCEC	chr11	65713017	Missense_Mutation	novel	G82R	0.44

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BRCA	DEL	0.1694	1.2183e-05
ESCA	AMP	0.212	0.018342
TGCT	DEL	0.7	0.21504

Survival Analysis

Cancer	P-value	Q-value
MESO	0.0074	Kaplan-Meier Survival Analysis
UCS	0.0086	Kaplan-Meier Survival Analysis
KIRP	0.012	Kaplan-Meier Survival Analysis
LAML	0.043	Kaplan-Meier Survival Analysis
LIHC	0.0044	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
UVM	0.017	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000172977 (Gene tree)
Gene ID: 10524
Gene Symbol: KAT5
Alias: TIP60|PLIP|cPLA2|HTATIP1|ESA1|ZC2HC5|HTATIP
Full Name: lysine acetyltransferase 5
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 7,611 bases
Position: chr11:65,711,996-65,719,606
Accession: 5275
RBP type: canonical RBP
Summary: The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000436247	Tudor-knot	PF11717.8	1.1e-18	1	1
ENSP00000344955	Tudor-knot	PF11717.8	5.1e-18	1	1
ENSP00000434765	Tudor-knot	PF11717.8	5.8e-18	1	1
ENSP00000366245	Tudor-knot	PF11717.8	6e-18	1	1
ENSP00000340330	Tudor-knot	PF11717.8	6.7e-18	1	1
ENSP00000436000	Tudor-knot	PF11717.8	5e-15	1	1
ENSP00000436012	Tudor-knot	PF11717.8	9.6e-15	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
18407291	Novel structural and functional mode of a knot essential for RNA binding activity of the Esa1 presumed chromodomain.	J Mol Biol	2008 May 16	Shimojo H	doi: 10.1016/j.jmb.2008.03.021
10839822	Acetylation of histones and transcription-related factors.	Microbiol Mol Biol Rev	2000 Jun	Sterner DE	-
14645238	E2F and Sp1/Sp3 Synergize but are not sufficient to activate the MYCN gene in neuroblastomas.	J Biol Chem	2004 Feb 13	Kramps C	-
26550034	Tip60 complex binds to active Pol II promoters and a subset of enhancers and co-regulates the c-Myc network in mouse embryonic stem cells.	Epigenetics Chromatin	2015 Nov 6	Ravens S	doi: 10.1186/s13072-015-0039-z
26551076	R loops regulate promoter-proximal chromatin architecture and cellular differentiation.	Nat Struct Mol Biol	2015 Dec	Chen PB	doi: 10.1038/nsmb.3122

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000352980	KAT5-202	2059	-	ENSP00000344955	461 (aa)	-	Q92993
ENST00000530446	KAT5-208	1697	-	ENSP00000434765	494 (aa)	-	Q92993
ENST00000525600	KAT5-205	512	-	-	- (aa)	-	-
ENST00000531880	KAT5-210	845	-	ENSP00000436012	269 (aa)	-	E9PRL6
ENST00000527544	KAT5-206	745	-	-	- (aa)	-	-
ENST00000534293	KAT5-215	559	-	-	- (aa)	-	-
ENST00000528198	KAT5-207	609	-	ENSP00000436000	189 (aa)	-	E9PRM3
ENST00000525204	KAT5-204	574	-	-	- (aa)	-	-
ENST00000530605	KAT5-209	499	-	ENSP00000436247	167 (aa)	-	H0YEP0
ENST00000341318	KAT5-201	2296	-	ENSP00000340330	546 (aa)	-	Q92993
ENST00000534104	KAT5-214	576	-	ENSP00000435939	16 (aa)	-	E9PRS1
ENST00000534650	KAT5-216	1875	-	ENSP00000431819	302 (aa)	-	E9PJI1
ENST00000377046	KAT5-203	2237	XM_006718421	ENSP00000366245	513 (aa)	XP_006718484	Q92993
ENST00000533441	KAT5-212	735	-	-	- (aa)	-	-
ENST00000534681	KAT5-217	583	-	ENSP00000434993	45 (aa)	-	E9PMG8
ENST00000533596	KAT5-213	709	-	ENSP00000435766	95 (aa)	-	H0YEG3
ENST00000532042	KAT5-211	763	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000172977's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa05166	Human T-cell leukemia virus 1 infection	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000172977	rs4645915	11	65714051	?	Red cell distribution width	30595370			EFO_0005192

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000172977's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000172977	KAT5	100	100.000	ENSAMEG00000017350	KAT5	100	99.805	Ailuropoda_melanoleuca
ENSG00000172977	KAT5	100	100.000	ENSANAG00000035412	KAT5	100	100.000	Aotus_nancymaae
ENSG00000172977	KAT5	100	99.669	ENSBTAG00000005578	KAT5	100	99.610	Bos_taurus
ENSG00000172977	KAT5	100	100.000	ENSCJAG00000001971	KAT5	100	100.000	Callithrix_jacchus
ENSG00000172977	KAT5	100	100.000	ENSCAFG00000013299	KAT5	100	99.783	Canis_familiaris
ENSG00000172977	KAT5	100	100.000	ENSCAFG00020015072	KAT5	100	97.838	Canis_lupus_dingo
ENSG00000172977	KAT5	100	99.669	ENSCHIG00000015445	KAT5	100	99.610	Capra_hircus
ENSG00000172977	KAT5	100	100.000	ENSTSYG00000034862	KAT5	100	99.805	Carlito_syrichta
ENSG00000172977	KAT5	100	100.000	ENSCPOG00000013693	KAT5	100	99.610	Cavia_porcellus
ENSG00000172977	KAT5	100	100.000	ENSCCAG00000033565	KAT5	100	100.000	Cebus_capucinus
ENSG00000172977	KAT5	100	100.000	ENSCATG00000038421	KAT5	100	89.091	Cercocebus_atys
ENSG00000172977	KAT5	100	100.000	ENSCLAG00000015794	KAT5	100	99.805	Chinchilla_lanigera
ENSG00000172977	KAT5	100	100.000	ENSCSAG00000007991	KAT5	100	98.276	Chlorocebus_sabaeus
ENSG00000172977	KAT5	100	98.013	ENSCPBG00000023405	KAT5	100	94.084	Chrysemys_picta_bellii
ENSG00000172977	KAT5	100	100.000	ENSCANG00000040731	KAT5	100	100.000	Colobus_angolensis_palliatus
ENSG00000172977	KAT5	100	100.000	ENSCGRG00001016070	Kat5	100	99.610	Cricetulus_griseus_chok1gshd
ENSG00000172977	KAT5	100	100.000	ENSCGRG00000010782	Kat5	100	99.610	Cricetulus_griseus_crigri
ENSG00000172977	KAT5	100	100.000	ENSDORG00000012563	Kat5	100	99.610	Dipodomys_ordii
ENSG00000172977	KAT5	100	100.000	ENSEASG00005004292	KAT5	100	99.610	Equus_asinus_asinus
ENSG00000172977	KAT5	100	100.000	ENSECAG00000014996	KAT5	100	99.451	Equus_caballus
ENSG00000172977	KAT5	100	100.000	ENSEEUG00000012808	-	61	100.000	Erinaceus_europaeus
ENSG00000172977	KAT5	100	100.000	ENSFCAG00000000038	KAT5	100	99.805	Felis_catus
ENSG00000172977	KAT5	100	100.000	ENSFDAG00000009343	KAT5	100	99.805	Fukomys_damarensis
ENSG00000172977	KAT5	100	98.013	ENSGAGG00000008186	KAT5	100	96.544	Gopherus_agassizii
ENSG00000172977	KAT5	100	100.000	ENSGGOG00000003283	KAT5	100	100.000	Gorilla_gorilla
ENSG00000172977	KAT5	100	100.000	ENSHGLG00000009569	KAT5	99	99.413	Heterocephalus_glaber_female
ENSG00000172977	KAT5	100	100.000	ENSHGLG00100016499	KAT5	100	99.220	Heterocephalus_glaber_male
ENSG00000172977	KAT5	100	100.000	ENSSTOG00000003133	KAT5	100	99.805	Ictidomys_tridecemlineatus
ENSG00000172977	KAT5	100	100.000	ENSJJAG00000023662	Kat5	100	99.805	Jaculus_jaculus
ENSG00000172977	KAT5	100	97.778	ENSLACG00000010274	KAT5	99	75.676	Latimeria_chalumnae
ENSG00000172977	KAT5	100	100.000	ENSLAFG00000015634	KAT5	100	99.084	Loxodonta_africana
ENSG00000172977	KAT5	100	100.000	ENSMFAG00000001136	KAT5	100	100.000	Macaca_fascicularis
ENSG00000172977	KAT5	100	100.000	ENSMMUG00000019839	KAT5	100	100.000	Macaca_mulatta
ENSG00000172977	KAT5	100	100.000	ENSMNEG00000035393	KAT5	100	100.000	Macaca_nemestrina
ENSG00000172977	KAT5	100	100.000	ENSMLEG00000035009	KAT5	100	100.000	Mandrillus_leucophaeus
ENSG00000172977	KAT5	100	100.000	ENSMAUG00000016030	Kat5	100	99.805	Mesocricetus_auratus
ENSG00000172977	KAT5	100	100.000	ENSMICG00000008880	KAT5	100	99.805	Microcebus_murinus
ENSG00000172977	KAT5	100	100.000	ENSMOCG00000009162	Kat5	100	99.805	Microtus_ochrogaster
ENSG00000172977	KAT5	100	99.338	ENSMODG00000009581	KAT5	100	95.091	Monodelphis_domestica
ENSG00000172977	KAT5	100	100.000	MGP_CAROLIEiJ_G0022561	Kat5	100	99.805	Mus_caroli
ENSG00000172977	KAT5	100	100.000	ENSMUSG00000024926	Kat5	100	99.805	Mus_musculus
ENSG00000172977	KAT5	100	100.000	MGP_PahariEiJ_G0014058	Kat5	100	99.805	Mus_pahari
ENSG00000172977	KAT5	100	100.000	MGP_SPRETEiJ_G0023475	Kat5	100	99.805	Mus_spretus
ENSG00000172977	KAT5	100	100.000	ENSMPUG00000011620	KAT5	100	99.805	Mustela_putorius_furo
ENSG00000172977	KAT5	100	100.000	ENSMLUG00000008754	KAT5	100	99.025	Myotis_lucifugus
ENSG00000172977	KAT5	100	100.000	ENSNGAG00000018671	Kat5	100	99.805	Nannospalax_galili
ENSG00000172977	KAT5	100	97.778	ENSNBRG00000020811	KAT5	99	71.735	Neolamprologus_brichardi
ENSG00000172977	KAT5	100	100.000	ENSNLEG00000005789	KAT5	100	97.619	Nomascus_leucogenys
ENSG00000172977	KAT5	100	99.338	ENSMEUG00000006191	KAT5	100	98.971	Notamacropus_eugenii
ENSG00000172977	KAT5	100	99.669	ENSODEG00000017848	KAT5	100	99.610	Octodon_degus
ENSG00000172977	KAT5	100	99.338	ENSOCUG00000013908	KAT5	100	99.025	Oryctolagus_cuniculus
ENSG00000172977	KAT5	100	100.000	ENSOGAG00000014123	KAT5	100	99.610	Otolemur_garnettii
ENSG00000172977	KAT5	100	99.669	ENSOARG00000017655	KAT5	100	97.441	Ovis_aries
ENSG00000172977	KAT5	100	100.000	ENSPPAG00000042045	KAT5	100	100.000	Pan_paniscus
ENSG00000172977	KAT5	100	100.000	ENSPPRG00000002162	KAT5	100	99.805	Panthera_pardus
ENSG00000172977	KAT5	100	100.000	ENSPTIG00000012360	KAT5	100	99.805	Panthera_tigris_altaica
ENSG00000172977	KAT5	100	100.000	ENSPTRG00000003890	KAT5	100	100.000	Pan_troglodytes
ENSG00000172977	KAT5	100	100.000	ENSPANG00000021813	KAT5	100	100.000	Papio_anubis
ENSG00000172977	KAT5	100	98.013	ENSPSIG00000002928	KAT5	100	95.736	Pelodiscus_sinensis
ENSG00000172977	KAT5	100	100.000	ENSPEMG00000015147	Kat5	100	99.805	Peromyscus_maniculatus_bairdii
ENSG00000172977	KAT5	100	99.338	ENSPCIG00000014346	KAT5	100	98.830	Phascolarctos_cinereus
ENSG00000172977	KAT5	100	100.000	ENSPPYG00000003052	KAT5	100	100.000	Pongo_abelii
ENSG00000172977	KAT5	100	100.000	ENSPCOG00000028886	KAT5	100	99.805	Propithecus_coquereli
ENSG00000172977	KAT5	100	100.000	ENSPVAG00000016949	KAT5	100	99.084	Pteropus_vampyrus
ENSG00000172977	KAT5	100	100.000	ENSRNOG00000061012	Kat5	99	99.794	Rattus_norvegicus
ENSG00000172977	KAT5	100	100.000	ENSRBIG00000038205	KAT5	100	100.000	Rhinopithecus_bieti
ENSG00000172977	KAT5	100	100.000	ENSRROG00000042827	KAT5	100	100.000	Rhinopithecus_roxellana
ENSG00000172977	KAT5	100	100.000	ENSSBOG00000020725	KAT5	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000172977	KAT5	100	100.000	ENSSARG00000011619	KAT5	100	89.194	Sorex_araneus
ENSG00000172977	KAT5	100	97.682	ENSSPUG00000000847	KAT5	100	95.146	Sphenodon_punctatus
ENSG00000172977	KAT5	100	100.000	ENSSSCG00000012980	KAT5	100	99.805	Sus_scrofa
ENSG00000172977	KAT5	100	100.000	ENSUAMG00000020794	KAT5	100	99.451	Ursus_americanus
ENSG00000172977	KAT5	100	100.000	ENSVVUG00000027078	KAT5	100	98.084	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	17360565.	IMP	Process
GO:0000123	histone acetyltransferase complex	21873635.	IBA	Component
GO:0000729	DNA double-strand break processing	-	TAS	Process
GO:0000790	nuclear chromatin	21873635.	IBA	Component
GO:0000812	Swr1 complex	24463511.	IDA	Component
GO:0003713	transcription coactivator activity	14966270.	IDA	Function
GO:0003713	transcription coactivator activity	17360565.	TAS	Function
GO:0004402	histone acetyltransferase activity	21873635.	IBA	Function
GO:0004402	histone acetyltransferase activity	18397884.	IDA	Function
GO:0004402	histone acetyltransferase activity	14966270.	IDA	Function
GO:0004402	histone acetyltransferase activity	17996965.	IMP	Function
GO:0005515	protein binding	10966108.15383276.15647280.16169070.16230350.17110330.17360565.17996965.18087039.18397884.18451177.18485870.18509338.19909775.21157427.21699783.21936881.21988832.22081016.22094252.24525235.25245946.25416956.26829474.27107012.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	17996965.24012345.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005667	transcription factor complex	-	IEA	Component
GO:0005730	nucleolus	16387653.	IDA	Component
GO:0006260	DNA replication	-	TAS	Process
GO:0006302	double-strand break repair	10966108.	IMP	Process
GO:0006303	double-strand break repair via nonhomologous end joining	-	TAS	Process
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	14966270.	IDA	Process
GO:0010212	response to ionizing radiation	18397884.	IDA	Process
GO:0010485	H4 histone acetyltransferase activity	21873635.	IBA	Function
GO:0016032	viral process	-	IEA	Process
GO:0016407	acetyltransferase activity	-	TAS	Function
GO:0016573	histone acetylation	10966108.	IDA	Process
GO:0030521	androgen receptor signaling pathway	15572661.	NAS	Process
GO:0032703	negative regulation of interleukin-2 production	17360565.	IDA	Process
GO:0032777	Piccolo NuA4 histone acetyltransferase complex	21873635.	IBA	Component
GO:0032777	Piccolo NuA4 histone acetyltransferase complex	14966270.	IDA	Component
GO:0035267	NuA4 histone acetyltransferase complex	10966108.14966270.	IDA	Component
GO:0040008	regulation of growth	-	IEA	Process
GO:0042393	histone binding	21873635.	IBA	Function
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	18397884.	IMP	Process
GO:0043967	histone H4 acetylation	-	IEA	Process
GO:0045892	negative regulation of transcription, DNA-templated	21873635.	IBA	Process
GO:0045892	negative regulation of transcription, DNA-templated	17360565.	IDA	Process
GO:0045893	positive regulation of transcription, DNA-templated	14966270.	IDA	Process
GO:0045893	positive regulation of transcription, DNA-templated	15572661.	NAS	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	23637611.	IMP	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0048471	perinuclear region of cytoplasm	-	IEA	Component
GO:0050681	androgen receptor binding	15572661.	NAS	Function
GO:0070491	repressing transcription factor binding	17360565.	IPI	Function
GO:0071392	cellular response to estradiol stimulus	23637611.	IDA	Process
GO:1901796	regulation of signal transduction by p53 class mediator	-	TAS	Process
GO:1901985	positive regulation of protein acetylation	24012345.	IDA	Process
GO:1904837	beta-catenin-TCF complex assembly	-	TAS	Process

EuRBPDB

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.