EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr3	122636001	Silent	NA	L646L	0.29
BLCA	chr3	122632216	Missense_Mutation	novel	E523D	0.17	PARP
BLCA	chr3	122635154	Silent	novel	V569V	0.39
BLCA	chr3	122635911	Nonsense_Mutation	NA	Y616*	0.19	PARP
BLCA	chr3	122617033	Missense_Mutation	rs367702270	S290C	0.18
BLCA	chr3	122635984	Missense_Mutation	novel	H641D	0.25	PARP
BRCA	chr3	122636033	Missense_Mutation	NA	P657L	0.57	PARP
BRCA	chr3	122621477	Missense_Mutation	novel	P366L	0.05
BRCA	chr3	122617030	Missense_Mutation	novel	V289A	0.14
BRCA	chr3	122626949	Missense_Mutation	NA	L452M	0.34
BRCA	chr3	122605973	Nonsense_Mutation	novel	S75*	0.26
BRCA	chr3	122626844	Missense_Mutation	novel	P417S	0.08
BRCA	chr3	122636082	Silent	novel	L673L	0.17
BRCA	chr3	122577794	Silent	NA	L43L	0.24
BRCA	chr3	122610546	Missense_Mutation	NA	P120Q	0.3
BRCA	chr3	122636180	3'Flank	novel		0.39
BRCA	chr3	122615691	Intron	novel		0.17
BRCA	chr3	122610718	Missense_Mutation	NA	E177D	0.13
BRCA	chr3	122615720	Intron	NA		0.23
BRCA	chr3	122632191	Missense_Mutation	rs745329291	R515Q	0.15	PARP
BRCA	chr3	122627024	In_Frame_Ins	novel	M477delinsIL	0.08
CESC	chr3	122577641	5'UTR	novel		0.21
CESC	chr3	122577770	Nonsense_Mutation	novel	R35*	0.11
CESC	chr3	122577664	5'UTR	novel		0.41
CESC	chr3	122577783	Missense_Mutation	novel	A39V	0.25
COAD	chr3	122613089	Frame_Shift_Del	novel	*F199Hfs7**	0.16
COAD	chr3	122610652	Silent	novel	S155S	0.36
COAD	chr3	122635088	Missense_Mutation	NA	K547N	0.39	PARP
COAD	chr3	122613181	Silent	NA	F228F	0.33
COAD	chr3	122632191	Missense_Mutation	rs745329291	R515Q	0.28	PARP
COAD	chr3	122626986	Missense_Mutation	novel	D464G	0.37
COAD	chr3	122615810	Missense_Mutation	NA	R268I	0.29
COAD	chr3	122626976	Frame_Shift_Del	NA	*R463Efs7**	0.29
COAD	chr3	122621600	Missense_Mutation	NA	A407V	0.52
COAD	chr3	122626834	Silent	rs766158836	A413A	0.32
COAD	chr3	122636105	3'UTR	novel		0.27
COAD	chr3	122626976	Frame_Shift_Del	NA	*R463Efs7**	0.18
COAD	chr3	122617100	Silent	rs140074948	D312D	0.33
COAD	chr3	122621491	Missense_Mutation	novel	K371E	0.13
COAD	chr3	122577616	5'UTR	novel		0.29
COAD	chr3	122626871	Missense_Mutation	rs749555610	D426N	0.08
COAD	chr3	122615820	Silent	rs756311515	P271P	0.3
COAD	chr3	122605963	Missense_Mutation	NA	D72Y	0.31
COAD	chr3	122626967	Missense_Mutation	rs200986074	D458N	0.38
COAD	chr3	122577818	Missense_Mutation	novel	R51W	0.27
COAD	chr3	122617091	Silent	NA	A309A	0.13
COAD	chr3	122636054	Missense_Mutation	rs747513128	F664C	0.25	PARP
GBM	chr3	122635841	Missense_Mutation	novel	A593D	0.22	PARP
GBM	chr3	122615810	Missense_Mutation	NA	R268I	0.57
HNSC	chr3	122626996	Silent	rs772723454	A467A	0.16
HNSC	chr3	122621451	Missense_Mutation	novel	Q357H	0.66
HNSC	chr3	122635938	Silent	novel	F625F	0.28
HNSC	chr3	122626907	Missense_Mutation	novel	P438T	0.42
HNSC	chr3	122615694	Intron	novel		0.22
KIRC	chr3	122626875	Missense_Mutation	NA	A427V	0.07
KIRP	chr3	122635918	Nonsense_Mutation	rs764796896	R619*	0.31	PARP
LGG	chr3	122615700	Intron	novel		0.33
LGG	chr3	122632207	Silent	novel	Y520Y	0.52
LUAD	chr3	122636124	3'UTR	novel		0.59
LUAD	chr3	122621486	Missense_Mutation	novel	C369F	0.09
LUAD	chr3	122636062	Missense_Mutation	NA	Q667E	0.22	PARP
LUAD	chr3	122635930	Missense_Mutation	novel	G623R	0.17	PARP
LUAD	chr3	122635019	Splice_Site	NA	X525_splice	0.27
LUAD	chr3	122635955	Missense_Mutation	novel	G631A	0.29	PARP
LUSC	chr3	122635996	Missense_Mutation	novel	D645N	0.18	PARP
LUSC	chr3	122636002	Missense_Mutation	novel	F647L	0.36	PARP
LUSC	chr3	122615676	Intron	novel		0.06
LUSC	chr3	122635118	Silent	NA	L557L	0.34
LUSC	chr3	122635107	Missense_Mutation	novel	E554K	0.27	PARP
LUSC	chr3	122635872	Silent	NA	T603T	0.37
LUSC	chr3	122635973	Missense_Mutation	NA	P637L	0.12	PARP
OV	chr3	122635898	Missense_Mutation	NA	R612K	0.05	PARP
OV	chr3	122635177	Missense_Mutation	NA	S577N	0.18	PARP
OV	chr3	122636157	3'Flank	novel		0.23
PAAD	chr3	122635119	Missense_Mutation	novel	F558V	0.2	PARP
PAAD	chr3	122626826	Splice_Site	novel	X411_splice	0.26
PRAD	chr3	122621585	Missense_Mutation	rs747548533	S402L	0.14
READ	chr3	122577816	Missense_Mutation	rs59971113	A50V	0.31
READ	chr3	122627020	Missense_Mutation	novel	F475L	0.35
READ	chr3	122610525	Missense_Mutation	NA	N113I	0.3
READ	chr3	122613181	Silent	NA	F228F	0.46
SARC	chr3	122626826	Splice_Site	novel	X411_splice	0.14
SKCM	chr3	122635823	Missense_Mutation	NA	G587E	0.3	PARP
SKCM	chr3	122626911	Missense_Mutation	novel	S439L	0.34
SKCM	chr3	122635081	Missense_Mutation	NA	D545V	0.13	PARP
SKCM	chr3	122621515	Missense_Mutation	NA	P379S	0.27
SKCM	chr3	122636110	3'UTR	novel		0.24
SKCM	chr3	122617056	Missense_Mutation	NA	E298K	0.25
SKCM	chr3	122632135	Missense_Mutation	NA	M496I	0.37
SKCM	chr3	122635990	Missense_Mutation	NA	P643S	0.3	PARP
SKCM	chr3	122635054	Missense_Mutation	NA	S536N	0.43	PARP
SKCM	chr3	122626988	Missense_Mutation	NA	L465F	0.17
SKCM	chr3	122632191	Missense_Mutation	rs745329291	R515Q	0.45	PARP
SKCM	chr3	122635126	Missense_Mutation	novel	G560E	0.52	PARP
SKCM	chr3	122615737	Intron	novel		0.37
SKCM	chr3	122636074	Missense_Mutation	NA	E671K	0.27	PARP
SKCM	chr3	122632203	Missense_Mutation	novel	S519F	0.47	PARP
SKCM	chr3	122635067	Silent	novel	K540K	0.17
SKCM	chr3	122626940	Nonsense_Mutation	NA	Q449*	0.23
SKCM	chr3	122632178	Missense_Mutation	NA	D511N	0.7	PARP
SKCM	chr3	122621521	Missense_Mutation	NA	G381R	0.21
SKCM	chr3	122615769	Intron	novel		0.28
STAD	chr3	122626976	Frame_Shift_Del	NA	*R463Efs7**	0.17
STAD	chr3	122617072	Missense_Mutation	NA	A303V	0.33
STAD	chr3	122621464	Missense_Mutation	NA	F362V	0.35
STAD	chr3	122626888	Missense_Mutation	NA	F431L	0.34
STAD	chr3	122615737	Intron	novel		0.09
STAD	chr3	122635850	Missense_Mutation	rs528176249	A596V	0.25	PARP
STAD	chr3	122636082	Silent	NA	L673L	0.18
STAD	chr3	122617070	Silent	NA	G302G	0.07
STAD	chr3	122626976	Frame_Shift_Del	NA	*R463Efs7**	0.14
TGCT	chr3	122577743	Missense_Mutation	novel	V26L	0.65
THYM	chr3	122632178	Missense_Mutation	novel	D511Y	0.14	PARP
UCEC	chr3	122615836	Missense_Mutation	NA	P277S	0.28
UCEC	chr3	122610501	Missense_Mutation	novel	V105A	0.32
UCEC	chr3	122615691	Intron	novel		0.49
UCEC	chr3	122615825	Missense_Mutation	novel	K273T	0.33
UCEC	chr3	122635074	Nonsense_Mutation	novel	Q543*	0.36	PARP
UCEC	chr3	122577616	5'UTR	novel		0.35
UCEC	chr3	122626871	Missense_Mutation	rs749555610	D426N	0.39
UCEC	chr3	122635088	Missense_Mutation	NA	K547N	0.59	PARP
UCEC	chr3	122615720	Intron	NA		0.19
UCEC	chr3	122621468	Missense_Mutation	NA	I363T	0.47
UCEC	chr3	122577636	5'UTR	novel		0.27
UCEC	chr3	122615720	Intron	NA		0.57
UCEC	chr3	122635996	Missense_Mutation	novel	D645Y	0.3	PARP
UCEC	chr3	122613110	Missense_Mutation	novel	P205S	0.4
UCEC	chr3	122636001	Silent	novel	L646L	0.4
UCEC	chr3	122613182	Missense_Mutation	rs774015138	E229K	0.24
UCEC	chr3	122615852	Missense_Mutation	novel	T282I	0.42
UCEC	chr3	122577605	5'UTR	novel		0.47
UCEC	chr3	122636122	3'UTR	novel		0.13
UCEC	chr3	122613182	Missense_Mutation	rs774015138	E229K	0.25
UCEC	chr3	122615778	Splice_Site	novel	X258_splice	0.09
UCEC	chr3	122626910	Missense_Mutation	NA	S439P	0.38
UCEC	chr3	122577728	Nonsense_Mutation	novel	E21*	0.29
UCEC	chr3	122636157	3'Flank	novel		0.29
UCEC	chr3	122617162	Missense_Mutation	NA	S333L	0.33
UCEC	chr3	122626963	Missense_Mutation	novel	F456L	0.26
UCEC	chr3	122610652	Silent	novel	S155S	0.37
UCEC	chr3	122626836	Frame_Shift_Ins	rs776159416	*N416Kfs7**	0.38
UCEC	chr3	122636141	3'UTR	novel		0.29
UCEC	chr3	122613140	Missense_Mutation	novel	P215S	0.38
UCEC	chr3	122626835	Missense_Mutation	rs151244693	G414R	0.18
UCEC	chr3	122615756	Intron	novel		0.18
UCEC	chr3	122615720	Intron	NA		0.3
UCEC	chr3	122632191	Missense_Mutation	rs745329291	R515Q	0.32	PARP
UCEC	chr3	122617161	Missense_Mutation	novel	S333A	0.26
UCEC	chr3	122626888	Silent	novel	F431F	0.53
UCEC	chr3	122613169	Frame_Shift_Ins	novel	*S225Efs15**	0.05
UCEC	chr3	122613170	In_Frame_Ins	novel	S225delinsFSHSALSP	0.05
UCEC	chr3	122621522	Missense_Mutation	NA	G381E	0.19
UCEC	chr3	122635918	Nonsense_Mutation	rs764796896	R619*	0.08	PARP
UCEC	chr3	122615772	Splice_Region	NA		0.43
UCEC	chr3	122636036	Missense_Mutation	NA	K658T	0.46	PARP
UCEC	chr3	122636157	3'Flank	novel		0.19
UCEC	chr3	122636052	Missense_Mutation	NA	F663L	0.28	PARP
UCEC	chr3	122636243	3'Flank	novel		0.24
UCEC	chr3	122610700	Silent	novel	Y171Y	0.45
UCEC	chr3	122635818	Silent	NA	S585S	0.32
UCEC	chr3	122577804	Missense_Mutation	novel	G46E	0.43
UCS	chr3	122636120	3'UTR	novel		0.24

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
GBM	DEL	0.0884	0.00094652
KIRC	DEL	0.1989	0.11092
LGG	DEL	0.0604	0.04374

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0015	Kaplan-Meier Survival Analysis
SARC	0.008	Kaplan-Meier Survival Analysis
ACC	0.026	Kaplan-Meier Survival Analysis
HNSC	0.0001	Kaplan-Meier Survival Analysis
SKCM	0.0001	Kaplan-Meier Survival Analysis
BRCA	0.022	Kaplan-Meier Survival Analysis
BLCA	0.0099	Kaplan-Meier Survival Analysis
CESC	0.0035	Kaplan-Meier Survival Analysis
LAML	0.028	Kaplan-Meier Survival Analysis
UCEC	0.0035	Kaplan-Meier Survival Analysis
LUAD	0.00018	Kaplan-Meier Survival Analysis
UVM	0.02	Kaplan-Meier Survival Analysis

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000173200 (Gene tree)
Gene ID: 165631
Gene Symbol: PARP15
Alias: FLJ40597|pART7
Full Name: poly(ADP-ribose) polymerase family member 15
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 61,594 bases
Position: chr3:122,577,454-122,639,047
Accession: 26876
RBP type: canonical RBP
Summary: PARP15 is a macrodomain-containing transcriptional repressor with poly(ADP-ribose) polymerase activity (Aguiar et al., 2005 [PubMed 16061477]).[supplied by OMIM, May 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000419488	PARP	PF00644.20	5.5e-26	1	1
ENSP00000308436	PARP	PF00644.20	7.1e-26	1	1
ENSP00000417785	PARP	PF00644.20	1.1e-25	1	1
ENSP00000417214	PARP	PF00644.20	1.9e-25	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000493645	PARP15-206	1311	-	ENSP00000419488	375 (aa)	-	B7ZL48
ENST00000465304	PARP15-203	1987	-	-	- (aa)	-	-
ENST00000310366	PARP15-201	1518	XM_011512478	ENSP00000308436	444 (aa)	XP_011510780	Q460N3
ENST00000473627	PARP15-204	559	-	-	- (aa)	-	-
ENST00000464300	PARP15-202	2156	XM_005247159	ENSP00000417214	678 (aa)	XP_005247216	Q460N3
ENST00000483793	PARP15-205	4439	XM_011512477	ENSP00000417785	483 (aa)	XP_011510779	C9J7L3

Gene Model

Click here to download ENSG00000173200's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000173200	Diabetes Mellitus	1.7792626E-6	17903298
ENSG00000173200	Electrocardiography	1E-6	20031603
ENSG00000173200	Periodontitis	3E-6	24024966
ENSG00000173200	Depressive Disorder	6E-6	22472876

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000173200	rs78411303	3	122637604	?	Periodontitis (CDC/AAP)	24024966	[1.47-2.56]	1.96	EFO_0000649
ENSG00000173200	rs2173763	3	122610313	?	Major depressive disorder	22472876			EFO_0003761

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000173200's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000173200	PARP15	94	76.263	ENSAMEG00000004886	PARP15	99	68.903	Ailuropoda_melanoleuca
ENSG00000173200	PARP15	94	88.265	ENSCJAG00000007967	PARP15	99	83.633	Callithrix_jacchus
ENSG00000173200	PARP15	99	76.531	ENSCAFG00000011953	PARP15	96	62.896	Canis_familiaris
ENSG00000173200	PARP15	99	76.531	ENSCAFG00020005735	PARP15	99	62.594	Canis_lupus_dingo
ENSG00000173200	PARP15	94	81.068	ENSTSYG00000005192	PARP15	99	76.905	Carlito_syrichta
ENSG00000173200	PARP15	97	87.755	ENSCCAG00000037492	PARP15	99	83.436	Cebus_capucinus
ENSG00000173200	PARP15	99	91.153	ENSCATG00000039420	PARP15	99	91.153	Cercocebus_atys
ENSG00000173200	PARP15	98	88.710	ENSCSAG00000007452	PARP15	99	88.372	Chlorocebus_sabaeus
ENSG00000173200	PARP15	99	90.909	ENSCANG00000001489	PARP15	99	90.909	Colobus_angolensis_palliatus
ENSG00000173200	PARP15	90	75.444	ENSEASG00005016550	-	98	75.444	Equus_asinus_asinus
ENSG00000173200	PARP15	94	74.359	ENSECAG00000008906	PARP15	99	72.381	Equus_caballus
ENSG00000173200	PARP15	93	73.469	ENSEEUG00000011427	-	85	73.469	Erinaceus_europaeus
ENSG00000173200	PARP15	99	78.061	ENSFCAG00000000929	PARP15	99	76.944	Felis_catus
ENSG00000173200	PARP15	100	98.758	ENSGGOG00000025733	PARP15	100	98.758	Gorilla_gorilla
ENSG00000173200	PARP15	99	88.113	ENSMFAG00000026206	PARP15	98	88.102	Macaca_fascicularis
ENSG00000173200	PARP15	97	90.547	ENSMMUG00000020547	PARP15	99	88.060	Macaca_mulatta
ENSG00000173200	PARP15	99	87.816	ENSMNEG00000039252	PARP15	99	91.150	Macaca_nemestrina
ENSG00000173200	PARP15	99	90.885	ENSMLEG00000034001	PARP15	99	90.885	Mandrillus_leucophaeus
ENSG00000173200	PARP15	99	72.472	ENSMICG00000049107	-	99	72.118	Microcebus_murinus
ENSG00000173200	PARP15	94	76.020	ENSMPUG00000004730	PARP15	94	71.667	Mustela_putorius_furo
ENSG00000173200	PARP15	99	73.727	ENSMLUG00000008245	-	99	73.727	Myotis_lucifugus
ENSG00000173200	PARP15	97	76.531	ENSMLUG00000027565	-	99	73.057	Myotis_lucifugus
ENSG00000173200	PARP15	95	72.447	ENSOGAG00000001802	PARP15	99	71.078	Otolemur_garnettii
ENSG00000173200	PARP15	95	98.578	ENSPPAG00000032565	PARP15	100	99.287	Pan_paniscus
ENSG00000173200	PARP15	99	77.551	ENSPPRG00000005753	PARP15	99	75.113	Panthera_pardus
ENSG00000173200	PARP15	99	77.551	ENSPTIG00000011576	PARP15	99	74.887	Panthera_tigris_altaica
ENSG00000173200	PARP15	100	99.172	ENSPTRG00000015296	PARP15	100	99.172	Pan_troglodytes
ENSG00000173200	PARP15	95	90.238	ENSPANG00000022333	PARP15	99	82.169	Papio_anubis
ENSG00000173200	PARP15	97	93.588	ENSPPYG00000013480	PARP15	99	93.588	Pongo_abelii
ENSG00000173200	PARP15	99	77.041	ENSPCOG00000025615	PARP15	99	73.529	Propithecus_coquereli
ENSG00000173200	PARP15	94	76.531	ENSPVAG00000012719	PARP15	99	72.965	Pteropus_vampyrus
ENSG00000173200	PARP15	95	90.261	ENSRBIG00000034163	PARP15	93	89.542	Rhinopithecus_bieti
ENSG00000173200	PARP15	60	91.729	ENSRROG00000030019	-	99	91.729	Rhinopithecus_roxellana
ENSG00000173200	PARP15	97	87.245	ENSSBOG00000019346	PARP15	99	83.894	Saimiri_boliviensis_boliviensis
ENSG00000173200	PARP15	97	65.641	ENSSSCG00000011875	PARP15	98	70.130	Sus_scrofa
ENSG00000173200	PARP15	79	49.505	ENSTBEG00000004304	-	97	54.817	Tupaia_belangeri
ENSG00000173200	PARP15	99	68.633	ENSUAMG00000022700	-	99	68.633	Ursus_americanus
ENSG00000173200	PARP15	99	72.118	ENSUMAG00000025218	-	95	78.061	Ursus_maritimus
ENSG00000173200	PARP15	94	76.020	ENSVVUG00000022532	PARP15	96	68.237	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	16061477.	IMP	Process
GO:0003714	transcription corepressor activity	16061477.	IMP	Function
GO:0003950	NAD+ ADP-ribosyltransferase activity	16061477.25635049.	IMP	Function
GO:0005515	protein binding	23473667.	IPI	Function
GO:0005634	nucleus	16061477.	IC	Component
GO:0070212	protein poly-ADP-ribosylation	16061477.25635049.	IMP	Process
GO:0070403	NAD+ binding	16061477.25635049.	IMP	Function
GO:1990404	protein ADP-ribosylase activity	25043379.	IDA	Function

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.