EuRBPDB

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Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr1	183648007	Missense_Mutation	NA	E259Q	0.1
BLCA	chr1	183648484	Missense_Mutation	novel	E100Q	0.08	APOBEC_N
BLCA	chr1	183648270	Missense_Mutation	rs139605657	R171H	0.2	APOBEC_N
BLCA	chr1	183648703	Missense_Mutation	novel	D27N	0.29
BLCA	chr1	183648572	Frame_Shift_Ins	novel	*E70Dfs12**	0.04	APOBEC_N
BLCA	chr1	183648129	Missense_Mutation	novel	R218T	0.4
BLCA	chr1	183647684	Missense_Mutation	novel	K366N	0.16
BLCA	chr1	183647707	Missense_Mutation	NA	E359K	0.12
BRCA	chr1	183648270	Missense_Mutation	rs139605657	R171H	0.42	APOBEC_N
BRCA	chr1	183647861	Silent	NA	G307G	0.58
BRCA	chr1	183647804	Silent	novel	S326S	0.09
CESC	chr1	183648661	Missense_Mutation	NA	A41S	0.49
CESC	chr1	183648235	Missense_Mutation	NA	R183W	0.3	APOBEC_N
CESC	chr1	183648007	Missense_Mutation	NA	E259Q	0.3
CHOL	chr1	183648487	Missense_Mutation	novel	F99I	0.13	APOBEC_N
COAD	chr1	183647814	Missense_Mutation	rs370218327	P323L	0.35
COAD	chr1	183648237	Missense_Mutation	rs756203206	P182L	0.47	APOBEC_N
COAD	chr1	183648149	Frame_Shift_Del	novel	*Q212Sfs4**	0.13
COAD	chr1	183647812	Missense_Mutation	NA	Q324K	0.22
COAD	chr1	183647766	Missense_Mutation	novel	G339E	0.13
COAD	chr1	183648519	Missense_Mutation	NA	T88I	0.35	APOBEC_N
COAD	chr1	183648495	Nonsense_Mutation	NA	S96*	0.25	APOBEC_N
COAD	chr1	183648002	Silent	novel	S260S	0.17
COAD	chr1	183648667	Frame_Shift_Ins	novel	*E39Tfs33**	0.07
COAD	chr1	183648668	Frame_Shift_Ins	novel	E39*	0.03
COAD	chr1	183648051	In_Frame_Del	NA	L244del	0.43
COAD	chr1	183648079	Missense_Mutation	rs760123722	V235I	0.32
KIRC	chr1	183648193	Missense_Mutation	NA	V197F	0.39	APOBEC_N
LAML	chr1	183648466	Missense_Mutation	NA	D106N	0.04	APOBEC_N
LAML	chr1	183647588	3'UTR	novel		0.11
LGG	chr1	183648459	Missense_Mutation	NA	A108V	0.13	APOBEC_N
LIHC	chr1	183648035	Missense_Mutation	NA	N249K	0.25
LIHC	chr1	183648193	Missense_Mutation	novel	V197L	0.33	APOBEC_N
LIHC	chr1	183647523	3'UTR	novel		0.29
LUAD	chr1	183647800	Missense_Mutation	NA	Q328K	0.07
LUAD	chr1	183648545	Silent	novel	V79V	0.2
LUAD	chr1	183647599	3'UTR	novel		0.07
LUAD	chr1	183648342	Missense_Mutation	novel	G147V	0.14	APOBEC_N
LUAD	chr1	183647832	Missense_Mutation	novel	V317A	0.11
LUAD	chr1	183648741	Missense_Mutation	NA	T14I	0.15
LUAD	chr1	183647570	3'UTR	novel		0.17
LUAD	chr1	183648722	Nonsense_Mutation	NA	Y20*	0.24
LUSC	chr1	183647965	Frame_Shift_Del	novel	*Q273Kfs23**	0.2
LUSC	chr1	183648351	Missense_Mutation	rs779521158	T144M	0.12	APOBEC_N
OV	chr1	183647594	3'UTR	novel		0.05
OV	chr1	183648661	Missense_Mutation	NA	A41T	0.33
PRAD	chr1	183648554	Silent	NA	G76G	0.12
READ	chr1	183648235	Missense_Mutation	NA	R183W	0.12	APOBEC_N
READ	chr1	183648334	Missense_Mutation	NA	L150I	0.35	APOBEC_N
READ	chr1	183648065	Missense_Mutation	NA	F239L	0.37
SKCM	chr1	183647666	3'UTR	novel		0.06
SKCM	chr1	183647667	3'UTR	novel		0.06
SKCM	chr1	183647657	3'UTR	novel		0.15
SKCM	chr1	183647884	Missense_Mutation	novel	D300N	0.22
SKCM	chr1	183648188	Silent	NA	L198L	0.11
SKCM	chr1	183648074	Silent	novel	K236K	0.39
SKCM	chr1	183648275	Nonsense_Mutation	novel	W169*	0.06	APOBEC_N
STAD	chr1	183648106	Missense_Mutation	rs776471890	A226T	0.15
STAD	chr1	183648177	Frame_Shift_Ins	novel	*I202Kfs24**	0.05	APOBEC_N
STAD	chr1	183648676	Nonsense_Mutation	rs778262711	R36*	0.34
UCEC	chr1	183647678	Silent	novel	*368*	0.07
UCEC	chr1	183648219	Missense_Mutation	NA	P188L	0.48	APOBEC_N
UCEC	chr1	183647391	3'UTR	novel		0.27
UCEC	chr1	183647809	Frame_Shift_Del	novel	*M325Cfs20**	0.4
UCEC	chr1	183648675	Missense_Mutation	rs753388975	R36Q	0.16
UCEC	chr1	183648351	Missense_Mutation	rs779521158	T144M	0.59	APOBEC_N
UCEC	chr1	183648127	Missense_Mutation	NA	A219T	0.29
UCEC	chr1	183647661	3'UTR	rs201458108		0.31
UCEC	chr1	183647781	Missense_Mutation	novel	G334V	0.51
UCEC	chr1	183648237	Missense_Mutation	rs756203206	P182L	0.31	APOBEC_N
UCEC	chr1	183648683	Silent	novel	Y33Y	0.26
UCEC	chr1	183648268	Missense_Mutation	rs141963987	E172K	0.51	APOBEC_N
UCEC	chr1	183647713	Missense_Mutation	NA	A357T	0.33
UCEC	chr1	183647619	3'UTR	novel		0.23
UCEC	chr1	183647807	Missense_Mutation	NA	M325I	0.46
UCEC	chr1	183648020	Silent	novel	A254A	0.19
UCEC	chr1	183648080	Silent	rs576673661	G234G	0.27
UCEC	chr1	183648488	Silent	novel	L98L	0.33
UCEC	chr1	183648350	Silent	rs549816614	T144T	0.06
UCEC	chr1	183647985	Missense_Mutation	novel	A266V	0.21
UCEC	chr1	183648579	Missense_Mutation	NA	F68C	0.34	APOBEC_N
UCEC	chr1	183648023	Missense_Mutation	rs775980223	K253N	0.6
UCEC	chr1	183648268	Missense_Mutation	rs141963987	E172K	0.32	APOBEC_N

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.0417	0.0017831
KIRC	AMP	0.0871	0.059566
PAAD	AMP	0.2283	0.085665
READ	AMP	0.2788	0.14328
TGCT	AMP	0.3467	0.088103
THCA	AMP	0.0501	0.075436

Survival Analysis

Cancer	P-value	Q-value
TGCT	0.042	Kaplan-Meier Survival Analysis
PAAD	0.0011	Kaplan-Meier Survival Analysis
UCEC	0.0086	Kaplan-Meier Survival Analysis
LUAD	0.026	Kaplan-Meier Survival Analysis

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000173627 (Gene tree)
Gene ID: 403314
Gene Symbol: APOBEC4
Alias: MGC26594|FLJ25691|RP1-127C7.4|C1orf169
Full Name: apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 7,042 bases
Position: chr1:183,646,275-183,653,316
Accession: 32152
RBP type: canonical RBP
Summary: This gene encodes a member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases, which convert cytidine to uridine. Other AID/APOBEC family members are involved in mRNA editing, somatic hypermutation and recombination of immunoglobulin genes, and innate immunity to retroviral infection. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000310622	APOBEC_N	PF08210.11	4.8e-28	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000308641	APOBEC4-201	2650	-	ENSP00000310622	367 (aa)	-	Q8WW27
ENST00000481562	APOBEC4-202	476	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000173627's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000173627	Lupus Erythematosus, Systemic	6E-6	23273568

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000173627	rs10911390	1	183647749	T	Systemic lupus erythematosus	23273568		1.13	EFO_0002690

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000173627's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000173627	APOBEC4	98	83.844	ENSAMEG00000002503	APOBEC4	94	83.844	Ailuropoda_melanoleuca
ENSG00000173627	APOBEC4	95	54.085	ENSACAG00000015192	APOBEC4	98	54.857	Anolis_carolinensis
ENSG00000173627	APOBEC4	96	80.226	ENSBTAG00000047395	APOBEC4	98	80.501	Bos_taurus
ENSG00000173627	APOBEC4	98	89.694	ENSCJAG00000040026	APOBEC4	97	89.694	Callithrix_jacchus
ENSG00000173627	APOBEC4	98	82.173	ENSCAFG00000013349	APOBEC4	98	82.173	Canis_familiaris
ENSG00000173627	APOBEC4	98	82.173	ENSCAFG00020015526	APOBEC4	98	82.173	Canis_lupus_dingo
ENSG00000173627	APOBEC4	96	78.531	ENSCHIG00000011987	APOBEC4	93	78.273	Capra_hircus
ENSG00000173627	APOBEC4	98	91.086	ENSCSAG00000000243	APOBEC4	98	91.086	Chlorocebus_sabaeus
ENSG00000173627	APOBEC4	100	80.926	ENSCHOG00000012387	APOBEC4	98	80.780	Choloepus_hoffmanni
ENSG00000173627	APOBEC4	99	54.496	ENSCPBG00000015714	APOBEC4	95	54.596	Chrysemys_picta_bellii
ENSG00000173627	APOBEC4	93	65.306	ENSCGRG00001004553	Apobec4	95	65.306	Cricetulus_griseus_chok1gshd
ENSG00000173627	APOBEC4	96	83.051	ENSDNOG00000044664	APOBEC4	98	82.730	Dasypus_novemcinctus
ENSG00000173627	APOBEC4	98	66.017	ENSDORG00000007335	Apobec4	99	66.017	Dipodomys_ordii
ENSG00000173627	APOBEC4	99	83.471	ENSEASG00005006513	APOBEC4	98	83.471	Equus_asinus_asinus
ENSG00000173627	APOBEC4	99	83.471	ENSECAG00000019734	APOBEC4	98	83.471	Equus_caballus
ENSG00000173627	APOBEC4	98	82.173	ENSFCAG00000010909	APOBEC4	98	82.173	Felis_catus
ENSG00000173627	APOBEC4	85	77.885	ENSFDAG00000018185	APOBEC4	98	77.885	Fukomys_damarensis
ENSG00000173627	APOBEC4	89	49.390	ENSGALG00000053078	APOBEC4	94	49.091	Gallus_gallus
ENSG00000173627	APOBEC4	100	98.641	ENSGGOG00000042217	APOBEC4	100	98.641	Gorilla_gorilla
ENSG00000173627	APOBEC4	99	50.811	ENSLACG00000014504	APOBEC4	97	51.648	Latimeria_chalumnae
ENSG00000173627	APOBEC4	60	37.220	ENSLOCG00000010326	-	88	36.400	Lepisosteus_oculatus
ENSG00000173627	APOBEC4	98	92.479	ENSMMUG00000031303	APOBEC4	98	92.479	Macaca_mulatta
ENSG00000173627	APOBEC4	93	47.661	ENSMGAG00000017190	APOBEC4	95	49.074	Meleagris_gallopavo
ENSG00000173627	APOBEC4	100	62.500	MGP_CAROLIEiJ_G0014701	Apobec4	94	63.056	Mus_caroli
ENSG00000173627	APOBEC4	100	61.685	ENSMUSG00000055547	Apobec4	94	62.222	Mus_musculus
ENSG00000173627	APOBEC4	100	62.500	MGP_PahariEiJ_G0027937	Apobec4	94	63.056	Mus_pahari
ENSG00000173627	APOBEC4	100	60.870	MGP_SPRETEiJ_G0015508	Apobec4	94	61.389	Mus_spretus
ENSG00000173627	APOBEC4	96	80.508	ENSMPUG00000011756	APOBEC4	95	80.780	Mustela_putorius_furo
ENSG00000173627	APOBEC4	96	77.966	ENSMLUG00000002458	APOBEC4	98	77.437	Myotis_lucifugus
ENSG00000173627	APOBEC4	98	59.610	ENSNGAG00000017599	Apobec4	97	59.444	Nannospalax_galili
ENSG00000173627	APOBEC4	100	96.739	ENSNLEG00000035610	APOBEC4	100	96.739	Nomascus_leucogenys
ENSG00000173627	APOBEC4	89	74.312	ENSODEG00000009778	APOBEC4	95	73.494	Octodon_degus
ENSG00000173627	APOBEC4	95	59.322	ENSOANG00000001000	APOBEC4	98	58.678	Ornithorhynchus_anatinus
ENSG00000173627	APOBEC4	98	78.273	ENSOGAG00000003118	APOBEC4	98	78.273	Otolemur_garnettii
ENSG00000173627	APOBEC4	96	79.944	ENSOARG00000005287	APOBEC4	98	79.666	Ovis_aries
ENSG00000173627	APOBEC4	100	94.823	ENSPPAG00000038272	APOBEC4	100	94.823	Pan_paniscus
ENSG00000173627	APOBEC4	98	83.008	ENSPPRG00000014706	APOBEC4	98	83.008	Panthera_pardus
ENSG00000173627	APOBEC4	98	82.730	ENSPTIG00000005518	APOBEC4	98	82.730	Panthera_tigris_altaica
ENSG00000173627	APOBEC4	100	98.365	ENSPTRG00000047181	APOBEC4	100	98.365	Pan_troglodytes
ENSG00000173627	APOBEC4	96	68.732	ENSPEMG00000019164	Apobec4	98	68.889	Peromyscus_maniculatus_bairdii
ENSG00000173627	APOBEC4	59	34.599	ENSPMAG00000006156	APOBEC4	97	30.919	Petromyzon_marinus
ENSG00000173627	APOBEC4	98	67.598	ENSPCIG00000003817	APOBEC4	95	67.409	Phascolarctos_cinereus
ENSG00000173627	APOBEC4	98	95.543	ENSPPYG00000000424	APOBEC4	98	95.543	Pongo_abelii
ENSG00000173627	APOBEC4	98	61.838	ENSPCAG00000015174	APOBEC4	98	61.667	Procavia_capensis
ENSG00000173627	APOBEC4	98	82.730	ENSPVAG00000001100	APOBEC4	98	82.730	Pteropus_vampyrus
ENSG00000173627	APOBEC4	100	62.060	ENSRNOG00000028089	Apobec4	91	62.327	Rattus_norvegicus
ENSG00000173627	APOBEC4	96	65.819	ENSSHAG00000013804	APOBEC4	98	65.278	Sarcophilus_harrisii
ENSG00000173627	APOBEC4	99	53.279	ENSSPUG00000010884	APOBEC4	95	53.782	Sphenodon_punctatus
ENSG00000173627	APOBEC4	100	80.926	ENSSSCG00000015561	APOBEC4	98	81.058	Sus_scrofa
ENSG00000173627	APOBEC4	98	80.780	ENSTBEG00000006476	APOBEC4	98	80.780	Tupaia_belangeri
ENSG00000173627	APOBEC4	98	81.564	ENSTTRG00000014784	APOBEC4	98	81.337	Tursiops_truncatus
ENSG00000173627	APOBEC4	96	83.523	ENSUAMG00000005088	APOBEC4	98	83.565	Ursus_americanus
ENSG00000173627	APOBEC4	96	83.239	ENSUMAG00000016285	APOBEC4	98	83.287	Ursus_maritimus
ENSG00000173627	APOBEC4	98	81.616	ENSVVUG00000009054	APOBEC4	98	81.616	Vulpes_vulpes
ENSG00000173627	APOBEC4	99	46.757	ENSXETG00000017441	apobec4	94	46.518	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0006397	mRNA processing	-	IEA	Process
GO:0016787	hydrolase activity	-	IEA	Function
GO:0046872	metal ion binding	-	IEA	Function

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.