EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
20737155	γ-Catenin is an independent prognostic marker in early stage colorectal cancer.	Int J Colorectal Dis	2010 Nov	Nagel JM	doi: 10.1007/s00384-010-1046-y
27144941	Plakoglobin Reduces the in vitro Growth, Migration and Invasion of Ovarian Cancer Cells Expressing N-Cadherin and Mutant p53.	PLoS One	2016 May 4	Alaee M	doi: 10.1371/journal.pone.0154323
28681073	γ-Catenin acts as a tumor suppressor through context-dependent mechanisms in colorectal cancer.	Int J Colorectal Dis	2017 Sep	Nagel JM	doi: 10.1007/s00384-017-2846-0
24914344	Down-regulated γ-catenin expression is associated with tumor aggressiveness in esophageal cancer.	World J Gastroenterol	2014 May 21	Fang WK	doi: 10.3748/wjg.v20.i19.5839.
23687381	Plakoglobin interacts with the transcription factor p53 and regulates the expression of 14-3-3??.	J Cell Sci	2013 Jul 15	Aktary Z	doi: 10.1242/jcs.120642
14517306	Tyrosine phosphorylation of plakoglobin causes contrary effects on its association with desmosomes and adherens junction components and modulates beta-catenin-mediated transcription.	Mol Cell Biol	2003 Oct	Miravet S	-
12386812	gamma-Catenin expression is reduced or absent in a subset of human lung cancers and re-expression inhibits transformed cell growth.	Oncogene	2002 Oct 24	Winn RA	-
22098624	SOX4 interacts with plakoglobin in a Wnt3a-dependent manner in prostate cancer cells.	BMC Cell Biol	2011 Nov 19	Lai YH	doi: 10.1186/1471-2121-12-50.
22496452	High motility of triple-negative breast cancer cells is due to repression of plakoglobin gene by metastasis modulator protein SLUG.	J Biol Chem	2012 Jun 1	Bailey CK	doi: 10.1074/jbc.M112.345728
15942628	Restoration of plakoglobin expression in bladder carcinoma cell lines suppresses cell migration and tumorigenic potential.	Br J Cancer	2005 Jun 20	Rieger-Christ KM	-
15781623	Functional Loss of the gamma-catenin gene through epigenetic and genetic pathways in human prostate cancer.	Cancer Res	2005 Mar 15	Shiina H	-
20529814	The expression of E-cadherin-catenin complex in patients with advanced gastric cancer: role in formation of metastasis.	Folia Histochem Cytobiol	2010 Jan 1	Czyzewska J	doi: 10.2478/v10042-010-0017-z.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr17	41757510	Missense_Mutation	novel	R651C	0.08
BLCA	chr17	41763022	Silent	NA	V486V	0.05
BLCA	chr17	41763256	Silent	rs2230408	L408L	0.37
BLCA	chr17	41771812	Missense_Mutation	novel	E15K	0.23
BLCA	chr17	41758423	Silent	rs782751412	L583L	0.23
BLCA	chr17	41757644	Silent	rs368772249	N638N	0.35
BLCA	chr17	41762984	Missense_Mutation	novel	K499R	0.19
BLCA	chr17	41763046	Silent	novel	L478L	0.25
BLCA	chr17	41769139	Silent	NA	L179L	0.26
BLCA	chr17	41763132	Missense_Mutation	rs782165604	D450N	0.09
BLCA	chr17	41755741	3'UTR	rs201552065		0.2
BLCA	chr17	41764716	Silent	novel	K385K	0.08
BLCA	chr17	41767451	Missense_Mutation	novel	K279N	0.09
BLCA	chr17	41763298	Missense_Mutation	NA	K394N	0.5
BLCA	chr17	41767550	Silent	NA	A246A	0.19
BRCA	chr17	41769517	Silent	rs781901019	L123L	0.31
BRCA	chr17	41757758	Missense_Mutation	novel	I600M	0.24
BRCA	chr17	41755088	3'UTR	novel		0.57
BRCA	chr17	41769138	Missense_Mutation	NA	M180L	0.32
BRCA	chr17	41758725	Missense_Mutation	novel	Q548L	0.24
BRCA	chr17	41767460	Silent	novel	L276L	0.25
BRCA	chr17	41763193	Silent	NA	V429V	0.22
BRCA	chr17	41763301	Silent	NA	L393L	0.15
CESC	chr17	41754684	3'UTR	novel		0.43
CESC	chr17	41755654	Intron	novel		0.17
CESC	chr17	41757678	Missense_Mutation	rs781883243;rs794729051	S627L	0.16
CESC	chr17	41755028	3'UTR	novel		0.24
CESC	chr17	41769427	Silent	rs376289528	D153D	0.12
CESC	chr17	41757678	Missense_Mutation	rs781883243;rs794729051	S627L	0.46
CESC	chr17	41771860	Splice_Region	novel		0.19
CESC	chr17	41763313	Silent	novel	L389L	0.33
CESC	chr17	41769139	Silent	novel	L179L	0.29
CESC	chr17	41758817	Frame_Shift_Ins	novel	*L518Afs93**	0.21
COAD	chr17	41767422	Missense_Mutation	novel	T289I	0.29
COAD	chr17	41763124	Silent	rs555082435	T452T	0.14
COAD	chr17	41755877	Missense_Mutation	rs200690479	R702H	0.38
COAD	chr17	41757528	Missense_Mutation	rs727504778	A645T	0.28
COAD	chr17	41769152	Missense_Mutation	rs782435477	S175L	0.28
COAD	chr17	41769537	Missense_Mutation	novel	A117T	0.67
COAD	chr17	41769549	Missense_Mutation	NA	L113M	0.22
COAD	chr17	41767511	Silent	rs34890640	G259G	0.41
COAD	chr17	41769549	Missense_Mutation	NA	L113M	0.12
COAD	chr17	41769086	Missense_Mutation	NA	S197N	0.38
COAD	chr17	41758716	Missense_Mutation	NA	T551M	0.22
COAD	chr17	41757473	Missense_Mutation	NA	R663H	0.41
COAD	chr17	41757736	Silent	rs782661058	L608L	0.38
COAD	chr17	41757703	Missense_Mutation	novel	D619N	0.19
COAD	chr17	41765039	Missense_Mutation	novel	Q313R	0.41
COAD	chr17	41758760	Missense_Mutation	NA	Q536H	0.41
COAD	chr17	41769516	Missense_Mutation	novel	K124E	0.25
COAD	chr17	41758503	Nonsense_Mutation	NA	E557*	0.51
DLBC	chr17	41769562	Silent	novel	G108G	0.11
ESCA	chr17	41769419	Missense_Mutation	rs782052422	P156L	0.22
ESCA	chr17	41755504	Intron	novel		0.16
GBM	chr17	41763171	Missense_Mutation	novel	A437P	0.1
GBM	chr17	41763115	Silent	rs77375949	A455A	0.44
HNSC	chr17	41758497	Missense_Mutation	novel	I559V	0.25
HNSC	chr17	41755788	Missense_Mutation	rs781885294	G732S	0.19
HNSC	chr17	41758457	Missense_Mutation	rs397517298	R572Q	0.16
HNSC	chr17	41757753	Missense_Mutation	novel	R602L	0.24
HNSC	chr17	41765032	Silent	rs146804895	L315L	0.12
HNSC	chr17	41764721	Missense_Mutation	novel	T384A	0.41
HNSC	chr17	41771662	Missense_Mutation	novel	V65L	0.3
HNSC	chr17	41763225	Missense_Mutation	novel	T419P	0.43
KIRC	chr17	41763021	Missense_Mutation	NA	K487Q	0.24
KIRC	chr17	41771678	Silent	NA	T59T	0.1
KIRP	chr17	41755694	Intron	novel		0.68
KIRP	chr17	41769565	Missense_Mutation	NA	E107D	0.24
LGG	chr17	41758442	Missense_Mutation	rs373434456	R577H	0.34
LGG	chr17	41771826	Missense_Mutation	novel	P10H	0.27
LGG	chr17	41755645	Intron	novel		0.45
LUAD	chr17	41757438	Missense_Mutation	NA	H675N	0.56
LUAD	chr17	41763180	Missense_Mutation	NA	G434C	0.34
LUAD	chr17	41771664	Missense_Mutation	NA	G64A	0.27
LUAD	chr17	41769051	Missense_Mutation	novel	L209M	0.19
LUSC	chr17	41767395	Missense_Mutation	NA	G298D	0.22
LUSC	chr17	41758831	Missense_Mutation	novel	A513S	0.63
LUSC	chr17	41758427	Missense_Mutation	rs781828085	R582Q	0.15
LUSC	chr17	41771716	Missense_Mutation	novel	E47K	0.19
LUSC	chr17	41758457	Missense_Mutation	rs397517298	R572Q	0.26
LUSC	chr17	41757511	Silent	NA	F650F	0.15
LUSC	chr17	41755757	Missense_Mutation	NA	H742R	0.2
LUSC	chr17	41763039	Missense_Mutation	novel	G481C	0.24
LUSC	chr17	41757426	Missense_Mutation	novel	A679S	0.07
OV	chr17	41755735	3'UTR	novel		0.53
OV	chr17	41758824	Missense_Mutation	NA	H515P	0.28
OV	chr17	41757644	Missense_Mutation	novel	N638K	0.41
OV	chr17	41763011	Missense_Mutation	NA	N490S	0.65
OV	chr17	41756188	In_Frame_Del	NA	E691del	0.26
PAAD	chr17	41763150	Missense_Mutation	rs781793865	R444C	0.18
PRAD	chr17	41755831	Silent	NA	H717H	0.45
PRAD	chr17	41758835	Silent	novel	C511C	0.18
PRAD	chr17	41755646	Intron	rs112151379		0.75
PRAD	chr17	41771726	Missense_Mutation	novel	M43I	0.27
READ	chr17	41769474	Missense_Mutation	rs150245906	E138K	0.29
READ	chr17	41757529	Silent	rs201704572	Y644Y	0.4
READ	chr17	41763271	Silent	novel	D403D	0.2
READ	chr17	41771788	Missense_Mutation	NA	D23N	0.39
SARC	chr17	41769525	Nonsense_Mutation	novel	Q121*	0.36
SKCM	chr17	41764960	Silent	rs782357007	S339S	0.32
SKCM	chr17	41764734	Silent	NA	L379L	0.35
SKCM	chr17	41758448	Missense_Mutation	novel	M575K	0.45
SKCM	chr17	41771770	Missense_Mutation	rs782501542	G29S	0.38
SKCM	chr17	41764951	Silent	NA	P342P	0.23
SKCM	chr17	41767424	Silent	novel	T288T	0.05
SKCM	chr17	41755625	Intron	novel		0.38
SKCM	chr17	41757631	Splice_Region	novel		0.4
SKCM	chr17	41771687	Silent	NA	K56K	0.54
SKCM	chr17	41765004	Missense_Mutation	rs781974007	E325K	0.5
SKCM	chr17	41763289	Silent	novel	V397V	0.35
SKCM	chr17	41763025	Silent	rs368692517	I485I	0.34
SKCM	chr17	41756185	Silent	NA	P692P	0.44
SKCM	chr17	41757448	Silent	NA	S671S	0.05
SKCM	chr17	41758444	Silent	NA	N576N	0.13
SKCM	chr17	41764772	Missense_Mutation	NA	R367C	0.25
SKCM	chr17	41757466	Silent	rs782094877	S665S	0.37
SKCM	chr17	41764961	Missense_Mutation	NA	S339F	0.36
SKCM	chr17	41769166	Silent	rs140539043	S170S	0.9
SKCM	chr17	41755852	Silent	NA	P710P	0.19
SKCM	chr17	41763000	Missense_Mutation	NA	Q494K	0.22
SKCM	chr17	41758432	Silent	novel	I580I	0.29
SKCM	chr17	41767577	Silent	NA	S237S	0.29
SKCM	chr17	41771742	Missense_Mutation	NA	S38N	0.26
SKCM	chr17	41771748	Missense_Mutation	NA	S36F	0.31
SKCM	chr17	41757466	Silent	rs782094877	S665S	0.29
SKCM	chr17	41758437	Missense_Mutation	NA	E579K	0.18
SKCM	chr17	41757722	Silent	NA	A612A	0.17
SKCM	chr17	41757420	Missense_Mutation	NA	E681K	0.27
SKCM	chr17	41758844	Silent	novel	L508L	0.89
SKCM	chr17	41755703	Intron	novel		0.19
SKCM	chr17	41763170	Missense_Mutation	NA	A437V	0.65
SKCM	chr17	41769600	Nonsense_Mutation	novel	E96*	0.44
SKCM	chr17	41757757	Nonsense_Mutation	novel	Q601*	0.45
SKCM	chr17	41763124	Silent	rs555082435	T452T	0.27
STAD	chr17	41767506	Missense_Mutation	novel	K261T	0.24
STAD	chr17	41767542	Missense_Mutation	rs377612199;rs786205277	T249M	0.25
STAD	chr17	41764771	Missense_Mutation	rs782067441	R367H	0.08
STAD	chr17	41765031	Missense_Mutation	rs782285849	V316M	0.1
STAD	chr17	41765034	Missense_Mutation	novel	L315F	0.06
STAD	chr17	41763102	Missense_Mutation	rs782575391	R460C	0.39
STAD	chr17	41763274	Silent	NA	V402V	0.08
STAD	chr17	41763263	Missense_Mutation	rs782188536	N406S	0.42
STAD	chr17	41769117	Missense_Mutation	NA	A187T	0.52
STAD	chr17	41769450	Missense_Mutation	rs146581757	E146K	0.5
STAD	chr17	41767494	Missense_Mutation	rs782440692	R265H	0.26
STAD	chr17	41769191	Missense_Mutation	rs369121094	A162V	0.19
STAD	chr17	41757482	Missense_Mutation	NA	Y660C	0.19
STAD	chr17	41769635	Missense_Mutation	rs782061304	R84Q	0.1
TGCT	chr17	41756185	Silent	NA	P692P	0.34
UCEC	chr17	41757466	Silent	rs782094877	S665S	0.39
UCEC	chr17	41754797	3'UTR	novel		0.38
UCEC	chr17	41757708	Missense_Mutation	rs782465804	A617V	0.3
UCEC	chr17	41767483	Missense_Mutation	novel	G269R	0.42
UCEC	chr17	41769593	Missense_Mutation	novel	S98N	0.44
UCEC	chr17	41769630	Missense_Mutation	rs782240305	R86W	0.31
UCEC	chr17	41755785	Missense_Mutation	novel	L733I	0.34
UCEC	chr17	41757700	Missense_Mutation	rs373919544	A620T	0.4
UCEC	chr17	41763185	Missense_Mutation	novel	N432T	0.41
UCEC	chr17	41767396	Missense_Mutation	rs199597864;rs794729041	G298S	0.43
UCEC	chr17	41758828	Missense_Mutation	NA	N514D	0.19
UCEC	chr17	41757754	Missense_Mutation	rs199511559	R602C	0.62
UCEC	chr17	41758491	Nonsense_Mutation	NA	E561*	0.23
UCEC	chr17	41767510	Missense_Mutation	rs149623442	A260T	0.32
UCEC	chr17	41755719	Intron	novel		0.24
UCEC	chr17	41769154	Silent	rs782745301	A174A	0.31
UCEC	chr17	41769480	Missense_Mutation	rs782392706	D136N	0.24
UCEC	chr17	41771734	Missense_Mutation	novel	G41S	0.26
UCEC	chr17	41758735	Missense_Mutation	NA	G545C	0.73
UCEC	chr17	41764731	Silent	NA	S380S	0.21
UCEC	chr17	41764741	Missense_Mutation	rs200433530;rs794729044	R377H	0.36
UCEC	chr17	41755032	3'UTR	novel		0.44
UCEC	chr17	41763244	Silent	novel	T412T	0.25
UCEC	chr17	41754737	3'UTR	rs543772543		0.42
UCEC	chr17	41757658	Missense_Mutation	novel	L634M	0.51
UCEC	chr17	41764741	Missense_Mutation	rs200433530;rs794729044	R377H	0.32
UCEC	chr17	41767483	Missense_Mutation	novel	G269R	0.58
UCEC	chr17	41758744	Missense_Mutation	rs571375136	V542I	0.4
UCEC	chr17	41757466	Silent	rs782094877	S665S	0.47
UCEC	chr17	41758498	Missense_Mutation	novel	E558D	0.61
UCEC	chr17	41763282	Missense_Mutation	NA	L400V	0.27
UCEC	chr17	41754706	3'UTR	novel		0.43
UCEC	chr17	41765018	Missense_Mutation	rs781965392	R320H	0.39
UCEC	chr17	41769022	Silent	rs112105828	G218G	0.12
UCEC	chr17	41757778	Missense_Mutation	novel	Y594H	0.33
UCEC	chr17	41754736	3'UTR	novel		0.41
UCEC	chr17	41763101	Missense_Mutation	rs397517296	R460H	0.36
UCEC	chr17	41769167	Missense_Mutation	rs782284038;rs794729034	S170L	0.24
UCEC	chr17	41771789	Silent	rs782575179	Y22Y	0.48
UCEC	chr17	41754989	3'UTR	novel		0.49
UCEC	chr17	41767495	Missense_Mutation	rs782761197	R265C	0.42
UCEC	chr17	41758736	Silent	novel	A544A	0.33
UCEC	chr17	41767511	Silent	rs34890640	G259G	0.33
UCEC	chr17	41767397	Silent	rs397517302	Y297Y	0.37
UCEC	chr17	41769537	Missense_Mutation	novel	A117S	0.44
UCEC	chr17	41767510	Missense_Mutation	rs149623442	A260T	0.29
UCEC	chr17	41765008	Missense_Mutation	novel	S323R	0.15
UCEC	chr17	41763194	Missense_Mutation	NA	V429A	0.34
UCEC	chr17	41754736	3'UTR	novel		0.31
UCEC	chr17	41758817	Silent	NA	P517P	0.58
UCEC	chr17	41763202	Silent	novel	K426K	0.2
UCEC	chr17	41764741	Missense_Mutation	rs200433530;rs794729044	R377H	0.47
UCEC	chr17	41756199	Missense_Mutation	NA	P688S	0.53
UCEC	chr17	41763181	Silent	rs376345105	S433S	0.31
UCEC	chr17	41767510	Missense_Mutation	rs149623442	A260T	0.33
UCEC	chr17	41757677	Silent	novel	S627S	0.5
UCEC	chr17	41764960	Silent	rs782357007	S339S	0.37
UCEC	chr17	41767395	Missense_Mutation	novel	G298V	0.4
UCEC	chr17	41771723	Silent	novel	E44E	0.53
UCEC	chr17	41755134	3'UTR	novel		0.4
UCEC	chr17	41764793	Missense_Mutation	novel	H360Y	0.39
UCS	chr17	41757757	Missense_Mutation	novel	Q601E	1

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.2778	0.0017784
DLBC	DEL	0	0.18166
THCA	DEL	0.002	0.221
UCEC	DEL	0.1929	5.8317e-06
UCS	DEL	0.3214	0.19877
UVM	DEL	0.0375	0.22482

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
SKCM	0.03	Kaplan-Meier Survival Analysis
PAAD	0.00018	Kaplan-Meier Survival Analysis
READ	0.016	Kaplan-Meier Survival Analysis
LAML	0.047	Kaplan-Meier Survival Analysis
KICH	0.016	Kaplan-Meier Survival Analysis
UCEC	0.0039	Kaplan-Meier Survival Analysis
GBM	0.017	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.012	Kaplan-Meier Survival Analysis
UVM	0.00026	Kaplan-Meier Survival Analysis
OV	0.0015	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000173801 (Gene tree)
Gene ID: 3728
Gene Symbol: JUP
Alias: DP3|PDGB|PKGB|DPIII|CTNNG
Full Name: junction plakoglobin
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 32,328 bases
Position: chr17:41,754,604-41,786,931
Accession: 6207
RBP type: non-canonical RBP
Summary: This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000449889	JUP-208	1069	-	ENSP00000389886	297 (aa)	-	C9JKY1
ENST00000437187	JUP-206	1029	-	ENSP00000394146	295 (aa)	-	C9JK18
ENST00000585793	JUP-210	598	-	-	- (aa)	-	-
ENST00000437369	JUP-207	586	-	ENSP00000409948	86 (aa)	-	C9JPI2
ENST00000465293	JUP-209	432	-	ENSP00000467065	2 (aa)	-	UPI000011EBE6
ENST00000393930	JUP-202	3298	-	ENSP00000377507	745 (aa)	-	P14923
ENST00000393931	JUP-203	3497	-	ENSP00000377508	745 (aa)	-	P14923
ENST00000424457	JUP-205	949	-	ENSP00000401034	235 (aa)	-	C9JTX4
ENST00000310706	JUP-201	3200	XM_006721874	ENSP00000311113	745 (aa)	XP_006721937	P14923
ENST00000420370	JUP-204	915	-	ENSP00000411449	276 (aa)	-	C9J826
ENST00000591690	JUP-212	583	-	ENSP00000468347	104 (aa)	-	K7ERP3
ENST00000589036	JUP-211	566	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000173801's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa05200	Pathways in cancer	KEGG
hsa05202	Transcriptional misregulation in cancer	KEGG
hsa05221	Acute myeloid leukemia	KEGG
hsa05226	Gastric cancer	KEGG
hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000173801	Electrocardiography	3E-8	24324551
ENSG00000173801	Trypanosoma cruzi	3E-8	24324551

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000173801	rs143043662	17	41757519	C	Heel bone mineral density	28869591	[0.059-0.116] unit decrease	0.0876303	EFO_0009270
ENSG00000173801	rs143043662	17	41757519	C	Heel bone mineral density	28869591	[0.048-0.126] unit decrease	0.0872999	EFO_0009270
ENSG00000173801	rs143043662	17	41757519	?	Heel bone mineral density	30048462	[0.059-0.097] unit decrease	0.0780376	EFO_0009270
ENSG00000173801	rs7213095	17	41784516	?	Heel bone mineral density	30048462	[0.0082-0.017] unit decrease	0.0125896	EFO_0009270
ENSG00000173801	rs143043662	17	41757519	C	Heel bone mineral density	30598549	[0.052-0.086] unit decrease	0.0687204	EFO_0009270
ENSG00000173801	rs41283425	17	41769461	?	Balding type 1	30595370			EFO_0007825
ENSG00000173801	rs41283425	17	41769461	T	Male-pattern baldness	30573740	[0.042-0.07] unit increase	0.0559405	EFO_0007825
ENSG00000173801	rs143043662	17	41757519	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000173801's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000173801	JUP	100	98.389	ENSMUSG00000001552	Jup	100	98.389	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001533	cornified envelope	-	TAS	Component
GO:0001954	positive regulation of cell-matrix adhesion	28115160.	IGI	Process
GO:0002159	desmosome assembly	22889254.	IDA	Process
GO:0002159	desmosome assembly	20859650.	IMP	Process
GO:0003713	transcription coactivator activity	21873635.	IBA	Function
GO:0003713	transcription coactivator activity	14661054.	IDA	Function
GO:0005198	structural molecule activity	22889254.	NAS	Function
GO:0005199	structural constituent of cell wall	7650039.	IC	Function
GO:0005515	protein binding	7650039.7890674.7983064.10801826.12370829.14661054.16189514.16917092.17098867.17510365.19060904.20859650.20936779.24965446.25241761.25416956.26496610.26871637.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005634	nucleus	14661054.	IMP	Component
GO:0005737	cytoplasm	14661054.	IMP	Component
GO:0005829	cytosol	-	ISS	Component
GO:0005856	cytoskeleton	-	ISS	Component
GO:0005882	intermediate filament	-	IEA	Component
GO:0005886	plasma membrane	14661054.20859650.	IDA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0005911	cell-cell junction	1639850.7650039.7983064.10460003.14661054.	IDA	Component
GO:0005913	cell-cell adherens junction	21873635.	IBA	Component
GO:0005913	cell-cell adherens junction	10403777.	IDA	Component
GO:0005915	zonula adherens	-	ISS	Component
GO:0005916	fascia adherens	-	IEA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0007016	cytoskeletal anchoring at plasma membrane	22889254.	NAS	Process
GO:0009898	cytoplasmic side of plasma membrane	-	ISS	Component
GO:0014704	intercalated disc	22781308.22889254.23381804.	IDA	Component
GO:0015629	actin cytoskeleton	-	IEA	Component
GO:0016327	apicolateral plasma membrane	-	IEA	Component
GO:0016328	lateral plasma membrane	-	IEA	Component
GO:0016342	catenin complex	21873635.	IBA	Component
GO:0016342	catenin complex	7650039.	IDA	Component
GO:0016477	cell migration	18937352.	IMP	Process
GO:0019901	protein kinase binding	-	IEA	Function
GO:0019903	protein phosphatase binding	21873635.	IBA	Function
GO:0019903	protein phosphatase binding	8663237.	IPI	Function
GO:0030018	Z disc	-	IEA	Component
GO:0030056	hemidesmosome	-	ISS	Component
GO:0030057	desmosome	1639850.	IDA	Component
GO:0031424	keratinization	-	TAS	Process
GO:0032993	protein-DNA complex	14661054.	IDA	Component
GO:0034332	adherens junction organization	-	TAS	Process
GO:0035257	nuclear hormone receptor binding	21873635.	IBA	Function
GO:0035580	specific granule lumen	-	TAS	Component
GO:0042127	regulation of cell proliferation	17924338.	IDA	Process
GO:0042307	positive regulation of protein import into nucleus	10825188.14661054.	IDA	Process
GO:0042803	protein homodimerization activity	-	ISS	Function
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0043537	negative regulation of blood vessel endothelial cell migration	28115160.	IGI	Process
GO:0045294	alpha-catenin binding	21873635.	IBA	Function
GO:0045294	alpha-catenin binding	7650039.7890674.23136403.	IPI	Function
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0045296	cadherin binding	21873635.	IBA	Function
GO:0045296	cadherin binding	1639850.7650039.	IPI	Function
GO:0045766	positive regulation of angiogenesis	28115160.	IGI	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0050839	cell adhesion molecule binding	17559062.	IPI	Function
GO:0050982	detection of mechanical stimulus	18937352.	IDA	Process
GO:0051091	positive regulation of DNA-binding transcription factor activity	14661054.	IDA	Process
GO:0051291	protein heterooligomerization	-	IEA	Process
GO:0070062	extracellular exosome	19056867.	HDA	Component
GO:0070268	cornification	-	TAS	Process
GO:0071603	endothelial cell-cell adhesion	-	ISS	Process
GO:0071665	gamma-catenin-TCF7L2 complex	14661054.	IDA	Component
GO:0071681	cellular response to indole-3-methanol	10868478.	IDA	Process
GO:0072659	protein localization to plasma membrane	20859650.	IMP	Process
GO:0086073	bundle of His cell-Purkinje myocyte adhesion involved in cell communication	17924338.	IMP	Process
GO:0086083	cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication	17924338.	IC	Function
GO:0086091	regulation of heart rate by cardiac conduction	17924338.	IMP	Process
GO:0090263	positive regulation of canonical Wnt signaling pathway	14661054.	IC	Process
GO:0098609	cell-cell adhesion	18937352.	IDA	Process
GO:0098609	cell-cell adhesion	20859650.	IMP	Process
GO:0098911	regulation of ventricular cardiac muscle cell action potential	17924338.	IMP	Process
GO:1904813	ficolin-1-rich granule lumen	-	TAS	Component

EuRBPDB

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Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

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