EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26784546	TGF-β/β2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome.	J Clin Invest	2016 Feb	Chen J	doi: 10.1172/JCI80937

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr11	66699450	Missense_Mutation	novel	I1244M	0.4
ACC	chr11	66715883	Missense_Mutation	rs776593274	R86W	0.49
BLCA	chr11	66696481	Silent	novel	L1358L	0.17
BLCA	chr11	66691512	Silent	NA	L1779L	0.24
BLCA	chr11	66693027	Missense_Mutation	NA	T1643S	0.28
BLCA	chr11	66705771	Missense_Mutation	rs372241839	E574K	0.24
BLCA	chr11	66704671	Missense_Mutation	novel	E869Q	0.33
BLCA	chr11	66701655	Silent	novel	A915A	0.54
BLCA	chr11	66701263	Missense_Mutation	NA	L946M	0.28
BLCA	chr11	66705356	Silent	novel	S640S	0.46
BLCA	chr11	66693240	Silent	rs146007976	A1600A	0.25
BLCA	chr11	66698731	Missense_Mutation	NA	E1308K	0.14
BLCA	chr11	66686373	Intron	novel		0.23
BLCA	chr11	66687518	Missense_Mutation	novel	R2211G	0.39
BLCA	chr11	66708986	Silent	novel	L369L	0.09
BLCA	chr11	66708277	Missense_Mutation	novel	A405V	0.53
BLCA	chr11	66708221	Missense_Mutation	novel	E424Q	0.78
BLCA	chr11	66689162	Nonsense_Mutation	NA	Q1990*	0.18
BLCA	chr11	66705004	Missense_Mutation	novel	D758N	0.47
BLCA	chr11	66687035	Silent	novel	V2285V	0.27
BLCA	chr11	66721155	Missense_Mutation	novel	P29L	0.31
BLCA	chr11	66696385	Missense_Mutation	novel	Q1390H	0.3
BRCA	chr11	66688774	Missense_Mutation	rs144215906	R2037H	0.14
BRCA	chr11	66692997	Missense_Mutation	NA	D1653G	0.34
BRCA	chr11	66693256	Missense_Mutation	rs763501939	R1595H	0.21
BRCA	chr11	66701598	Missense_Mutation	novel	E934D	0.37
BRCA	chr11	66689176	Missense_Mutation	novel	S1985L	0.25
BRCA	chr11	66687561	Missense_Mutation	NA	Q2196H	0.65
BRCA	chr11	66694340	Silent	novel	V1434V	0.26
BRCA	chr11	66689147	Missense_Mutation	rs374895441	R1995C	0.19
BRCA	chr11	66694254	Missense_Mutation	rs768355416	S1463L	0.19
BRCA	chr11	66699062	Missense_Mutation	NA	A1266E	0.39
BRCA	chr11	66693040	Missense_Mutation	rs138405793	D1639N	0.28
BRCA	chr11	66691410	Silent	NA	A1813A	0.3
BRCA	chr11	66707582	Silent	NA	L529L	0.29
BRCA	chr11	66699568	Missense_Mutation	novel	Q1205L	0.07
BRCA	chr11	66687509	Missense_Mutation	novel	E2214K	0.4
BRCA	chr11	66689930	Missense_Mutation	NA	A1942T	0.84
BRCA	chr11	66713634	Missense_Mutation	NA	E257K	0.2
BRCA	chr11	66701232	Nonsense_Mutation	NA	S956*	0.32
BRCA	chr11	66696414	Missense_Mutation	NA	D1381H	0.24
CESC	chr11	66714371	Missense_Mutation	novel	E174K	0.32
CESC	chr11	66705061	Missense_Mutation	rs376230007	R739C	0.32
CESC	chr11	66699570	Silent	NA	L1204L	0.18
CESC	chr11	66694243	Nonsense_Mutation	NA	E1467*	0.15
CESC	chr11	66694253	Silent	NA	S1463S	0.13
CESC	chr11	66688755	Silent	novel	C2043C	0.29
CESC	chr11	66691331	Missense_Mutation	novel	R1840C	0.37
CESC	chr11	66700654	Missense_Mutation	novel	A1149T	0.45
CESC	chr11	66700540	Missense_Mutation	rs369739429	V1187M	0.19
CESC	chr11	66687604	Frame_Shift_Ins	novel	*R2182Ifs108**	0.13
CESC	chr11	66715282	Frame_Shift_Del	novel	*I141Mfs8**	0.09
CESC	chr11	66700669	Nonsense_Mutation	novel	R1144*	0.34
CESC	chr11	66700945	Missense_Mutation	novel	A1052S	0.13
CESC	chr11	66710916	Splice_Site	novel	X295_splice	0.26
CESC	chr11	66714091	Missense_Mutation	novel	R219Q	0.26
CESC	chr11	66708938	Silent	rs773673472	T385T	0.46
CESC	chr11	66690086	Silent	NA	L1921L	0.25
CESC	chr11	66692613	Missense_Mutation	NA	D1705N	0.17
CESC	chr11	66707656	Missense_Mutation	NA	R505W	0.24
CHOL	chr11	66696474	Silent	novel	L1361L	0.53
COAD	chr11	66687160	Missense_Mutation	NA	Q2244K	0.23
COAD	chr11	66691436	Missense_Mutation	rs373877632	R1805C	0.39
COAD	chr11	66710731	Missense_Mutation	NA	E308D	0.39
COAD	chr11	66715842	Silent	rs762103483	S99S	0.16
COAD	chr11	66704774	Silent	rs780176754	Y834Y	0.56
COAD	chr11	66705199	Missense_Mutation	NA	R693W	0.5
COAD	chr11	66714327	Missense_Mutation	novel	M188I	0.26
COAD	chr11	66687021	Missense_Mutation	rs200100829	R2290Q	0.44
COAD	chr11	66687548	Missense_Mutation	NA	E2201K	0.88
COAD	chr11	66687095	Silent	novel	S2265S	0.08
COAD	chr11	66694240	Missense_Mutation	novel	E1468K	0.32
COAD	chr11	66705786	Silent	NA	L569L	0.31
COAD	chr11	66691455	Silent	rs764744589	A1798A	0.31
COAD	chr11	66721124	Silent	rs142080780	S39S	0.28
COAD	chr11	66690266	Silent	rs557448224	D1861D	0.29
COAD	chr11	66715922	Missense_Mutation	rs536375005	R73W	0.4
COAD	chr11	66701265	Missense_Mutation	rs377663856	R945H	0.27
COAD	chr11	66690045	Missense_Mutation	rs145750214	R1935H	0.11
COAD	chr11	66699414	Silent	novel	I1256I	0.3
COAD	chr11	66689946	Splice_Region	NA		0.56
COAD	chr11	66694258	Missense_Mutation	NA	T1462A	0.37
COAD	chr11	66701629	Frame_Shift_Del	NA	*P924Qfs35**	0.39
COAD	chr11	66689181	Splice_Site	novel	X1984_splice	0.1
COAD	chr11	66689822	Missense_Mutation	novel	H1978N	0.18
COAD	chr11	66688748	Missense_Mutation	NA	D2046N	0.57
COAD	chr11	66710720	Missense_Mutation	novel	S312F	0.5
COAD	chr11	66704714	Silent	novel	L854L	0.2
COAD	chr11	66687868	Splice_Region	NA	P2167P	0.44
COAD	chr11	66685923	Missense_Mutation	novel	G2374D	0.1
COAD	chr11	66688201	Silent	rs762025497	G2114G	0.22
COAD	chr11	66693205	Missense_Mutation	novel	M1612T	0.31
COAD	chr11	66686433	Missense_Mutation	novel	D2302N	0.09
COAD	chr11	66691358	Missense_Mutation	rs771882386	D1831N	0.37
COAD	chr11	66699503	Missense_Mutation	rs766811381	R1227W	0.3
COAD	chr11	66700719	Missense_Mutation	novel	L1127P	0.45
COAD	chr11	66707636	Silent	NA	R511R	0.3
COAD	chr11	66698674	Missense_Mutation	novel	A1327P	0.48
COAD	chr11	66710710	Silent	rs758056414	S315S	0.25
COAD	chr11	66701196	Missense_Mutation	rs767999498	T968M	0.15
ESCA	chr11	66699041	Missense_Mutation	rs557577438	R1273H	0.27
ESCA	chr11	66687895	Frame_Shift_Del	novel	*L2158Rfs130**	0.36
ESCA	chr11	66693032	Silent	rs200296553	A1641A	0.36
ESCA	chr11	66691403	Missense_Mutation	NA	R1816W	0.21
ESCA	chr11	66691471	Missense_Mutation	novel	R1793Q	0.44
ESCA	chr11	66698995	Silent	rs764690665	H1288H	0.45
ESCA	chr11	66691361	Missense_Mutation	novel	R1830C	0.24
GBM	chr11	66701229	Missense_Mutation	novel	A957V	0.09
GBM	chr11	66692623	Silent	rs199954244	R1701R	0.43
GBM	chr11	66721158	Missense_Mutation	novel	L28P	0.08
GBM	chr11	66691405	Missense_Mutation	novel	A1815V	0.28
GBM	chr11	66693293	Nonsense_Mutation	novel	R1583*	0.42
GBM	chr11	66693408	Silent	rs139176086	I1544I	0.25
GBM	chr11	66696465	Missense_Mutation	rs372626707	R1364C	0.45
GBM	chr11	66691610	Missense_Mutation	novel	G1747C	0.08
GBM	chr11	66692566	Silent	rs763157375	H1720H	0.91
GBM	chr11	66688793	Missense_Mutation	novel	S2031C	0.15
GBM	chr11	66693222	Silent	novel	E1606E	0.15
GBM	chr11	66691349	Missense_Mutation	rs745978030	A1834T	0.14
GBM	chr11	66693261	Missense_Mutation	novel	F1593L	0.51
GBM	chr11	66693030	Missense_Mutation	novel	Q1642L	0.15
GBM	chr11	66721087	Missense_Mutation	novel	A52T	0.17
GBM	chr11	66715893	Silent	novel	Y82Y	0.36
GBM	chr11	66714123	Silent	novel	G208G	0.45
HNSC	chr11	66693067	Frame_Shift_Del	novel	*Q1624Pfs26**	0.11
HNSC	chr11	66691508	Missense_Mutation	rs777756110	E1781K	0.31
HNSC	chr11	66688289	Missense_Mutation	rs143781509	R2085Q	0.32
HNSC	chr11	66699462	Silent	novel	S1240S	0.31
HNSC	chr11	66694316	Silent	novel	I1442I	0.29
HNSC	chr11	66687469	Missense_Mutation	rs370257588	R2227H	0.36
HNSC	chr11	66721230	Missense_Mutation	rs749463565	T4M	0.13
HNSC	chr11	66704974	Missense_Mutation	NA	R768C	0.14
HNSC	chr11	66699456	Silent	novel	G1242G	0.29
HNSC	chr11	66708931	Missense_Mutation	rs773857389	E388K	0.27
HNSC	chr11	66701005	Nonsense_Mutation	NA	Q1032*	0.09
HNSC	chr11	66700949	Silent	novel	L1050L	0.3
HNSC	chr11	66715835	Frame_Shift_Del	novel	*I102Yfs47**	0.18
HNSC	chr11	66696479	Missense_Mutation	novel	R1359T	0.24
HNSC	chr11	66693241	Missense_Mutation	novel	A1600V	0.24
HNSC	chr11	66705724	Silent	rs748966229	A589A	0.13
HNSC	chr11	66692569	Silent	novel	S1719S	0.22
HNSC	chr11	66696467	Missense_Mutation	novel	R1363K	0.15
KIRC	chr11	66686384	Intron	rs370403561		0.33
KIRC	chr11	66690236	Silent	novel	A1871A	0.15
KIRC	chr11	66692572	Frame_Shift_Del	novel	*S1719Pfs11**	0.21
KIRC	chr11	66704780	Silent	novel	R832R	0.2
KIRC	chr11	66715917	Silent	NA	V74V	0.28
KIRP	chr11	66721094	Missense_Mutation	NA	K49N	0.49
KIRP	chr11	66700812	Missense_Mutation	NA	T1096N	0.54
KIRP	chr11	66705373	Missense_Mutation	novel	A635T	0.38
LAML	chr11	66701683	Missense_Mutation	novel	A906V	0.15
LGG	chr11	66693406	Missense_Mutation	rs150801133	A1545V	0.21
LGG	chr11	66698692	Missense_Mutation	novel	A1321T	0.34
LGG	chr11	66704627	Silent	novel	R883R	0.2
LIHC	chr11	66699084	Splice_Site	novel	X1259_splice	0.3
LIHC	chr11	66688835	Missense_Mutation	novel	V2017L	0.28
LIHC	chr11	66708182	Missense_Mutation	novel	R437W	0.23
LIHC	chr11	66705410	Missense_Mutation	NA	S622R	0.63
LIHC	chr11	66696425	Missense_Mutation	rs767535278	R1377H	0.37
LIHC	chr11	66704827	Silent	novel	L817L	0.41
LIHC	chr11	66705772	Silent	rs148207416	H573H	0.4
LIHC	chr11	66700872	Missense_Mutation	novel	D1076V	0.21
LIHC	chr11	66715925	Missense_Mutation	novel	A72S	0.06
LIHC	chr11	66693284	Missense_Mutation	NA	D1586Y	0.37
LUAD	chr11	66693082	Missense_Mutation	rs751736175	A1625T	0.22
LUAD	chr11	66704931	Missense_Mutation	rs755618733	T782M	0.29
LUAD	chr11	66687868	Splice_Region	NA	P2167P	0.46
LUAD	chr11	66685895	Missense_Mutation	novel	F2383L	0.08
LUAD	chr11	66688171	Splice_Region	rs770289355	D2124D	0.21
LUAD	chr11	66694188	Missense_Mutation	novel	Q1485R	0.09
LUAD	chr11	66692617	Silent	NA	L1703L	0.11
LUAD	chr11	66689929	Missense_Mutation	NA	A1942V	0.37
LUAD	chr11	66700902	Missense_Mutation	rs527626787	R1066Q	0.09
LUAD	chr11	66721111	Missense_Mutation	novel	E44Q	0.06
LUAD	chr11	66691452	Silent	rs769209192	A1799A	0.13
LUAD	chr11	66685895	Silent	novel	F2383F	0.24
LUAD	chr11	66704908	Missense_Mutation	novel	R790W	0.28
LUAD	chr11	66700710	Missense_Mutation	novel	E1130A	0.67
LUAD	chr11	66710754	Missense_Mutation	NA	M301L	0.11
LUAD	chr11	66699577	Missense_Mutation	novel	G1202V	0.15
LUAD	chr11	66715856	Missense_Mutation	NA	L95F	0.37
LUAD	chr11	66708243	Silent	rs775075151	E416E	0.26
LUAD	chr11	66707669	Missense_Mutation	novel	K500N	0.29
LUAD	chr11	66694187	Missense_Mutation	NA	Q1485H	0.18
LUAD	chr11	66692981	Missense_Mutation	NA	E1658D	0.72
LUAD	chr11	66693259	Missense_Mutation	novel	Y1594F	0.24
LUAD	chr11	66707711	Silent	rs576311723	A486A	0.06
LUAD	chr11	66710704	Silent	novel	L317L	0.16
LUSC	chr11	66705465	Missense_Mutation	NA	Y604C	0.4
LUSC	chr11	66701061	Missense_Mutation	novel	A1013V	0.64
LUSC	chr11	66692595	Frame_Shift_Del	novel	*Q1708Rfs19**	0.33
LUSC	chr11	66705373	Missense_Mutation	NA	A635S	0.23
LUSC	chr11	66715894	Missense_Mutation	NA	Y82C	0.75
LUSC	chr11	66688259	Missense_Mutation	rs774653711	R2095Q	0.13
LUSC	chr11	66700825	Missense_Mutation	NA	E1092K	0.3
LUSC	chr11	66707665	Missense_Mutation	novel	I502F	0.55
LUSC	chr11	66705325	Missense_Mutation	novel	G651R	0.22
LUSC	chr11	66699003	Missense_Mutation	novel	D1286N	0.57
LUSC	chr11	66705700	Missense_Mutation	novel	F597L	0.3
LUSC	chr11	66704904	Missense_Mutation	NA	A791V	0.22
LUSC	chr11	66721224	Missense_Mutation	NA	S6L	0.15
LUSC	chr11	66701608	Missense_Mutation	NA	N931S	0.11
LUSC	chr11	66693292	Missense_Mutation	NA	R1583Q	0.21
LUSC	chr11	66689811	Silent	rs761380862	A1981A	0.2
LUSC	chr11	66701583	Splice_Site	novel	X939_splice	0.38
LUSC	chr11	66687596	Missense_Mutation	rs765660173	R2185W	0.17
LUSC	chr11	66715377	Missense_Mutation	NA	R110C	0.11
LUSC	chr11	66707606	Silent	rs370685694	A521A	0.2
LUSC	chr11	66700903	Missense_Mutation	novel	R1066W	0.14
MESO	chr11	66686120	Intron	novel		0.16
OV	chr11	66693076	Missense_Mutation	NA	V1627L	0.37
OV	chr11	66693073	Missense_Mutation	novel	K1628E	0.11
OV	chr11	66710925	Missense_Mutation	novel	I293V	0.07
OV	chr11	66687581	Frame_Shift_Del	novel	*A2190Pfs127**	0.23
OV	chr11	66696368	Missense_Mutation	novel	E1396G	0.6
OV	chr11	66691412	Frame_Shift_Del	NA	*A1813Pfs107**	0.29
OV	chr11	66691414	Frame_Shift_Del	novel	*R1805Qfs108**	0.25
OV	chr11	66688188	Missense_Mutation	NA	S2119T	0.33
OV	chr11	66704950	Missense_Mutation	novel	G776R	0.08
OV	chr11	66699503	Missense_Mutation	rs766811381	R1227W	0.34
OV	chr11	66691339	Missense_Mutation	novel	A1837V	0.06
OV	chr11	66708938	Silent	novel	T385T	0.06
OV	chr11	66686087	Missense_Mutation	NA	W2319C	0.08
OV	chr11	66688844	Nonsense_Mutation	NA	E2014*	0.12
OV	chr11	66693226	Frame_Shift_Del	novel	*G1605Afs7**	0.04
OV	chr11	66704657	In_Frame_Ins	novel	Q873_W874insLSV	0.36
OV	chr11	66694350	Missense_Mutation	novel	E1431V	0.04
PAAD	chr11	66687505	Missense_Mutation	novel	P2215L	0.1
PAAD	chr11	66700973	Missense_Mutation	novel	E1042D	0.15
PAAD	chr11	66685856	3'UTR	novel		0.14
PAAD	chr11	66687590	Missense_Mutation	NA	R2187W	0.19
PAAD	chr11	66688724	Missense_Mutation	rs761586529	R2054W	0.2
PAAD	chr11	66692703	Silent	novel	L1675L	0.18
PAAD	chr11	66694288	Missense_Mutation	novel	E1452K	0.04
PAAD	chr11	66700655	Missense_Mutation	novel	E1148D	0.18
PAAD	chr11	66704699	Silent	rs777964981	S859S	0.15
PCPG	chr11	66689814	Silent	novel	A1980A	0.98
PCPG	chr11	66685817	3'UTR	novel		0.42
PRAD	chr11	66701058	Missense_Mutation	NA	R1014Q	0.16
PRAD	chr11	66699027	Missense_Mutation	rs373743022	R1278W	0.44
PRAD	chr11	66686233	Intron	novel		0.31
PRAD	chr11	66691323	Silent	novel	H1842H	0.4
PRAD	chr11	66694361	Missense_Mutation	novel	M1427I	0.31
PRAD	chr11	66707768	Silent	rs747312193	H467H	0.1
READ	chr11	66710639	Missense_Mutation	NA	G339E	0.28
READ	chr11	66699060	Missense_Mutation	novel	A1267T	0.15
READ	chr11	66687522	Silent	rs753498663	P2209P	0.61
READ	chr11	66710741	Missense_Mutation	rs770418403	R305H	0.35
READ	chr11	66694182	Missense_Mutation	novel	S1487Y	0.15
READ	chr11	66692579	Missense_Mutation	novel	V1716A	0.34
READ	chr11	66687095	Silent	novel	S2265S	0.49
READ	chr11	66688745	Missense_Mutation	rs201985455	E2047K	0.41
READ	chr11	66715341	Missense_Mutation	rs376084729	A122T	0.55
SARC	chr11	66690106	Missense_Mutation	novel	A1915P	0.11
SARC	chr11	66690107	Silent	novel	K1914K	0.11
SARC	chr11	66708911	Missense_Mutation	novel	D394E	0.07
SARC	chr11	66705834	Missense_Mutation	rs116099040	R553W	0.5
SARC	chr11	66692576	Missense_Mutation	rs376579703	A1717V	0.63
SKCM	chr11	66689889	Silent	rs771691919	E1955E	0.53
SKCM	chr11	66693810	Missense_Mutation	NA	D1519N	0.36
SKCM	chr11	66700951	Missense_Mutation	novel	L1050F	0.32
SKCM	chr11	66707579	Silent	NA	N530N	0.77
SKCM	chr11	66708201	Silent	rs538691061	F430F	0.19
SKCM	chr11	66688693	Missense_Mutation	NA	A2064V	0.2
SKCM	chr11	66705693	Missense_Mutation	NA	P600S	0.28
SKCM	chr11	66699476	Missense_Mutation	rs201646010	R1236C	0.5
SKCM	chr11	66701064	Missense_Mutation	novel	A1012V	0.06
SKCM	chr11	66700624	Nonsense_Mutation	NA	R1159*	0.6
SKCM	chr11	66705014	Silent	rs368022952	A754A	0.72
SKCM	chr11	66687527	Silent	NA	L2208L	0.47
SKCM	chr11	66714396	Silent	NA	I165I	0.45
SKCM	chr11	66700902	Missense_Mutation	rs527626787	R1066Q	0.26
SKCM	chr11	66707612	Missense_Mutation	NA	M519I	0.28
SKCM	chr11	66686337	Intron	novel		0.41
SKCM	chr11	66693254	Missense_Mutation	NA	D1596N	0.23
SKCM	chr11	66700893	Missense_Mutation	NA	D1069G	0.21
SKCM	chr11	66707585	Silent	NA	L528L	0.2
SKCM	chr11	66691403	Missense_Mutation	NA	R1816W	0.68
SKCM	chr11	66687042	Missense_Mutation	novel	G2283D	0.1
SKCM	chr11	66687043	Missense_Mutation	novel	G2283S	0.1
SKCM	chr11	66700912	Missense_Mutation	NA	E1063K	0.51
SKCM	chr11	66705688	Silent	NA	G601G	0.32
SKCM	chr11	66691521	Silent	novel	K1776K	0.06
SKCM	chr11	66694254	Missense_Mutation	rs768355416	S1463L	0.71
SKCM	chr11	66701040	Missense_Mutation	rs758312194	R1020Q	0.48
SKCM	chr11	66708977	Silent	NA	I372I	0.33
SKCM	chr11	66707714	Silent	rs761617060	D485D	0.09
SKCM	chr11	66687594	Silent	NA	R2185R	0.32
SKCM	chr11	66707519	Missense_Mutation	novel	M550I	0.19
SKCM	chr11	66688016	Silent	NA	G2146G	0.58
SKCM	chr11	66690192	Missense_Mutation	NA	A1886V	0.5
SKCM	chr11	66700756	Missense_Mutation	novel	E1115K	0.42
SKCM	chr11	66700757	Silent	novel	V1114V	0.42
SKCM	chr11	66691291	Missense_Mutation	NA	S1853N	0.27
SKCM	chr11	66705122	Silent	novel	A718A	0.62
SKCM	chr11	66701165	Silent	novel	T978T	0.13
SKCM	chr11	66701269	Missense_Mutation	rs750219209	R944W	0.19
SKCM	chr11	66690079	Missense_Mutation	NA	D1924N	0.42
SKCM	chr11	66708209	Missense_Mutation	NA	A428T	0.33
SKCM	chr11	66689844	Silent	NA	G1970G	0.08
SKCM	chr11	66689879	Missense_Mutation	rs774111091	R1959W	0.24
SKCM	chr11	66701140	Silent	novel	L987L	0.29
SKCM	chr11	66700771	Silent	novel	L1110L	0.57
SKCM	chr11	66700772	Silent	novel	A1109A	0.62
SKCM	chr11	66708144	Silent	novel	S449S	0.31
SKCM	chr11	66686375	Intron	novel		0.42
SKCM	chr11	66704994	Missense_Mutation	novel	A761V	0.49
STAD	chr11	66693413	Missense_Mutation	rs779489841	R1543W	0.19
STAD	chr11	66691455	Silent	rs764744589	A1798A	0.63
STAD	chr11	66705373	Missense_Mutation	novel	A635P	0.14
STAD	chr11	66698724	Missense_Mutation	rs201852582	R1310H	0.11
STAD	chr11	66698693	Missense_Mutation	NA	Q1320H	0.14
STAD	chr11	66704907	Missense_Mutation	NA	R790Q	0.35
STAD	chr11	66692694	Missense_Mutation	rs768814631	G1678S	0.24
STAD	chr11	66705723	Missense_Mutation	rs780059779	V590I	0.18
STAD	chr11	66715371	Missense_Mutation	NA	R112W	0.44
STAD	chr11	66687129	Missense_Mutation	novel	S2254I	0.3
STAD	chr11	66699514	Missense_Mutation	novel	A1223V	0.32
STAD	chr11	66704820	Missense_Mutation	rs753107176	R819H	0.47
STAD	chr11	66711027	Missense_Mutation	rs767017885	V259M	0.22
STAD	chr11	66686093	Silent	NA	S2317S	0.25
STAD	chr11	66708938	Silent	rs773673472	T385T	0.1
STAD	chr11	66693038	Missense_Mutation	NA	D1639E	0.1
STAD	chr11	66692587	Silent	rs146602750	R1713R	0.3
STAD	chr11	66694204	Missense_Mutation	rs113974204	R1480C	0.34
STAD	chr11	66694204	Missense_Mutation	rs113974204	R1480C	0.12
STAD	chr11	66700555	Frame_Shift_Del	novel	*R1182Vfs37**	0.34
STAD	chr11	66715842	Silent	rs762103483	S99S	0.37
STAD	chr11	66700852	Missense_Mutation	novel	R1083C	0.11
STAD	chr11	66708991	Silent	novel	L368L	0.09
STAD	chr11	66708992	Silent	rs765495317	V367V	0.08
STAD	chr11	66692582	Missense_Mutation	NA	V1715A	0.34
STAD	chr11	66700796	Missense_Mutation	NA	E1101D	0.31
STAD	chr11	66685935	Missense_Mutation	rs145522851	R2370H	0.16
STAD	chr11	66700903	Missense_Mutation	novel	R1066W	0.22
STAD	chr11	66692678	Missense_Mutation	novel	A1683V	0.38
STAD	chr11	66701156	Silent	rs139352096	I981I	0.24
STAD	chr11	66691349	Missense_Mutation	rs745978030	A1834T	0.28
STAD	chr11	66694192	Missense_Mutation	NA	L1484M	0.11
STAD	chr11	66701671	Missense_Mutation	rs532746761	A910V	0.2
STAD	chr11	66705437	Silent	rs774265056	S613S	0.23
STAD	chr11	66688752	Silent	rs754538137	T2044T	0.15
STAD	chr11	66694293	Missense_Mutation	NA	A1450V	0.29
TGCT	chr11	66693799	Missense_Mutation	novel	S1522R	0.05
THCA	chr11	66715932	In_Frame_Ins	novel	T64_S69dup	0.05
THCA	chr11	66705362	Silent	rs367863277	E638E	0.12
THCA	chr11	66688268	Frame_Shift_Del	novel	*E2092Gfs225**	0.18
UCEC	chr11	66700930	Nonsense_Mutation	rs781377530	R1057*	0.5
UCEC	chr11	66715229	Missense_Mutation	NA	R159Q	0.31
UCEC	chr11	66700540	Missense_Mutation	rs369739429	V1187M	0.25
UCEC	chr11	66692625	Missense_Mutation	rs770136906	R1701C	0.4
UCEC	chr11	66693313	Missense_Mutation	NA	E1576G	0.24
UCEC	chr11	66704886	Missense_Mutation	rs763402581	R797Q	0.52
UCEC	chr11	66686253	Intron	rs576615351		0.18
UCEC	chr11	66691435	Missense_Mutation	novel	R1805H	0.11
UCEC	chr11	66699043	Silent	NA	G1272G	0.18
UCEC	chr11	66699517	Missense_Mutation	novel	D1222G	0.32
UCEC	chr11	66714132	Nonsense_Mutation	novel	W205*	0.42
UCEC	chr11	66708933	Missense_Mutation	rs772590586	R387H	0.36
UCEC	chr11	66704709	Missense_Mutation	NA	T856I	0.19
UCEC	chr11	66704839	Missense_Mutation	novel	L813M	0.5
UCEC	chr11	66715898	Missense_Mutation	rs772427786	L81M	0.3
UCEC	chr11	66701629	Frame_Shift_Del	NA	*P924Qfs35**	0.14
UCEC	chr11	66704739	Missense_Mutation	novel	R846Q	0.48
UCEC	chr11	66686038	Missense_Mutation	rs765015336	E2336K	0.78
UCEC	chr11	66687869	Missense_Mutation	novel	P2167L	0.39
UCEC	chr11	66685779	3'UTR	novel		0.15
UCEC	chr11	66687868	Splice_Region	NA	P2167P	0.49
UCEC	chr11	66686270	Intron	rs535980731		0.15
UCEC	chr11	66715842	Silent	rs762103483	S99S	0.22
UCEC	chr11	66696425	Missense_Mutation	rs767535278	R1377H	0.14
UCEC	chr11	66699060	Missense_Mutation	novel	A1267S	0.09
UCEC	chr11	66699445	Missense_Mutation	NA	A1246V	0.21
UCEC	chr11	66707767	Missense_Mutation	novel	E468K	0.33
UCEC	chr11	66711021	Missense_Mutation	NA	V261M	0.42
UCEC	chr11	66715352	Missense_Mutation	NA	N118S	0.42
UCEC	chr11	66686424	Nonsense_Mutation	NA	E2305*	0.06
UCEC	chr11	66699058	Silent	rs776179938	A1267A	0.09
UCEC	chr11	66687589	Missense_Mutation	rs775830950	R2187Q	0.24
UCEC	chr11	66691290	Silent	NA	S1853S	0.18
UCEC	chr11	66691544	Missense_Mutation	rs146455382	R1769W	0.48
UCEC	chr11	66701092	Missense_Mutation	rs770666144	G1003S	0.32
UCEC	chr11	66692622	Missense_Mutation	rs781647988	E1702K	0.17
UCEC	chr11	66710962	Missense_Mutation	NA	F280L	0.43
UCEC	chr11	66693408	Missense_Mutation	novel	I1544M	0.36
UCEC	chr11	66710927	Missense_Mutation	NA	R292I	0.39
UCEC	chr11	66688730	Missense_Mutation	novel	I2052V	0.31
UCEC	chr11	66689928	Silent	rs373276784	A1942A	0.24
UCEC	chr11	66701051	Silent	rs540897209	G1016G	0.32
UCEC	chr11	66704816	Silent	rs776096922	T820T	0.32
UCEC	chr11	66691453	Missense_Mutation	rs775098613	A1799V	0.42
UCEC	chr11	66692589	Missense_Mutation	rs754809056	R1713C	0.48
UCEC	chr11	66700763	Silent	novel	G1112G	0.48
UCEC	chr11	66687155	Silent	rs750664912	N2245N	0.38
UCEC	chr11	66705798	Nonsense_Mutation	novel	G565*	0.33
UCEC	chr11	66693010	Missense_Mutation	NA	A1649T	0.44
UCEC	chr11	66699033	Missense_Mutation	novel	D1276H	0.65
UCEC	chr11	66704709	Missense_Mutation	NA	T856I	0.37
UCEC	chr11	66715312	Silent	novel	V131V	0.06
UCEC	chr11	66704737	Missense_Mutation	novel	A847T	0.5
UCEC	chr11	66701629	Frame_Shift_Del	NA	*P924Qfs35**	0.2
UCEC	chr11	66689146	Missense_Mutation	rs139107445	R1995H	0.41
UCEC	chr11	66721101	Missense_Mutation	rs768391963	R47H	0.22
UCEC	chr11	66694248	Missense_Mutation	novel	A1465V	0.46
UCEC	chr11	66696277	Missense_Mutation	novel	Q1426H	0.42
UCEC	chr11	66696428	Missense_Mutation	novel	A1376V	0.54
UCEC	chr11	66721096	Missense_Mutation	novel	K49E	0.52
UCEC	chr11	66685963	Missense_Mutation	rs374211174	V2361I	0.41
UCEC	chr11	66698767	Missense_Mutation	NA	E1296K	0.33
UCEC	chr11	66704891	Missense_Mutation	NA	E795D	0.41
UCEC	chr11	66686261	Intron	novel		0.18
UCEC	chr11	66699073	Missense_Mutation	novel	K1262N	0.5
UCEC	chr11	66715226	Missense_Mutation	novel	F160S	0.13
UCEC	chr11	66693033	Missense_Mutation	rs376009552	A1641V	0.27
UCEC	chr11	66685964	Silent	rs368166748	P2360P	0.38
UCEC	chr11	66701249	Silent	novel	K950K	0.54
UCEC	chr11	66704887	Nonsense_Mutation	NA	R797*	0.1
UCEC	chr11	66710927	Missense_Mutation	NA	R292I	0.42
UCEC	chr11	66701195	Silent	rs143948660	T968T	0.32
UCEC	chr11	66704701	Missense_Mutation	novel	S859R	0.46
UCEC	chr11	66700586	Silent	novel	A1171A	0.09
UCEC	chr11	66700907	Silent	rs371684236	A1064A	0.24
UCEC	chr11	66686325	Intron	novel		0.08
UCEC	chr11	66687015	Missense_Mutation	novel	R2292H	0.33
UCEC	chr11	66689146	Missense_Mutation	rs139107445	R1995H	0.29
UCEC	chr11	66687034	Missense_Mutation	NA	A2286T	0.46
UCEC	chr11	66687583	Missense_Mutation	rs376249009	P2189L	0.44
UCEC	chr11	66698758	Missense_Mutation	novel	L1299M	0.38
UCEC	chr11	66693376	Missense_Mutation	novel	G1555V	0.15
UCEC	chr11	66685700	3'UTR	novel		0.41
UCEC	chr11	66685799	3'UTR	novel		0.19
UCEC	chr11	66694254	Missense_Mutation	rs768355416	S1463L	0.43
UCEC	chr11	66721252	5'UTR	novel		0.18
UCEC	chr11	66688068	Missense_Mutation	rs777143650	R2129Q	0.09
UCEC	chr11	66686202	Intron	novel		0.45
UCEC	chr11	66686991	Splice_Region	rs777655867		0.3
UCEC	chr11	66687612	Silent	novel	R2179R	0.42
UCEC	chr11	66691478	Missense_Mutation	novel	D1791N	0.41
UCEC	chr11	66700608	Missense_Mutation	NA	R1164Q	0.31
UCEC	chr11	66694276	Missense_Mutation	NA	A1456T	0.26
UCEC	chr11	66699542	Frame_Shift_Ins	novel	*L1214Tfs28**	0.32
UCEC	chr11	66690100	Missense_Mutation	NA	R1917W	0.36
UCEC	chr11	66701189	Silent	NA	T970T	0.4
UCEC	chr11	66707759	Silent	novel	I470I	0.13
UCEC	chr11	66707605	Missense_Mutation	rs376773049	A522T	0.38
UCEC	chr11	66691582	Missense_Mutation	rs754055406	A1756V	0.43
UCEC	chr11	66688069	Missense_Mutation	rs556784868	R2129W	0.29
UCEC	chr11	66699543	Frame_Shift_Del	novel	*K1213Nfs6**	0.42
UCEC	chr11	66687629	Missense_Mutation	NA	E2174K	0.3
UCEC	chr11	66688045	Missense_Mutation	NA	P2137T	0.3
UCEC	chr11	66688694	Missense_Mutation	NA	A2064T	0.23
UCEC	chr11	66710927	Missense_Mutation	NA	R292I	0.29
UCEC	chr11	66721362	5'UTR	novel		0.38
UCEC	chr11	66685875	Missense_Mutation	novel	K2390T	0.22
UCEC	chr11	66698738	Silent	novel	S1305S	0.53
UCEC	chr11	66685971	Missense_Mutation	novel	V2358A	0.15
UCEC	chr11	66686118	Intron	rs189152678		0.28
UCEC	chr11	66688015	Missense_Mutation	novel	E2147K	0.15
UCEC	chr11	66693392	Missense_Mutation	rs757086442	R1550W	0.49
UCEC	chr11	66696448	Missense_Mutation	novel	E1369D	0.39
UCEC	chr11	66715229	Missense_Mutation	NA	R159Q	0.44
UCEC	chr11	66688762	Missense_Mutation	novel	L2041P	0.52
UCEC	chr11	66698661	Missense_Mutation	novel	D1331G	0.4
UCEC	chr11	66686161	Intron	novel		0.5
UCEC	chr11	66692718	Missense_Mutation	NA	A1670T	0.11
UCEC	chr11	66700865	Missense_Mutation	novel	Q1078H	0.25
UCEC	chr11	66701672	Missense_Mutation	NA	A910T	0.38
UCEC	chr11	66710598	Missense_Mutation	novel	V353M	0.36
UCEC	chr11	66705834	Missense_Mutation	rs116099040	R553W	0.32
UCEC	chr11	66701586	Splice_Region	NA	H938H	0.31
UCEC	chr11	66691652	Nonsense_Mutation	novel	R1733*	0.39
UCEC	chr11	66692587	Silent	rs146602750	R1713R	0.32
UCEC	chr11	66693077	Silent	novel	E1626E	0.25
UCEC	chr11	66693241	Missense_Mutation	novel	A1600V	0.44
UCEC	chr11	66701266	Missense_Mutation	rs201807685	R945C	0.39
UCEC	chr11	66704813	Silent	novel	P821P	0.4
UCEC	chr11	66707731	Missense_Mutation	rs397514749	R480W	0.38
UCEC	chr11	66687055	Missense_Mutation	novel	A2279T	0.24
UCEC	chr11	66689130	Missense_Mutation	novel	E2000D	0.47
UCEC	chr11	66696435	Missense_Mutation	rs199675740	A1374T	0.42
UCEC	chr11	66701021	Silent	novel	A1026A	0.4
UCEC	chr11	66701189	Silent	rs769498634	T970T	0.26

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ESCA	AMP	0.2554	0.018342
TGCT	DEL	0.7	0.21504

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
SARC	0.011	Kaplan-Meier Survival Analysis
UCS	0.034	Kaplan-Meier Survival Analysis
HNSC	0.032	Kaplan-Meier Survival Analysis
SKCM	0.039	Kaplan-Meier Survival Analysis
ESCA	0.026	Kaplan-Meier Survival Analysis
COAD	0.025	Kaplan-Meier Survival Analysis
PAAD	0.00075	Kaplan-Meier Survival Analysis
BLCA	0.0015	Kaplan-Meier Survival Analysis
LAML	0.0031	Kaplan-Meier Survival Analysis
UCEC	0.027	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.008	Kaplan-Meier Survival Analysis
UVM	0.039	Kaplan-Meier Survival Analysis
OV	0.044	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000173898 (Gene tree)
Gene ID: 6712
Gene Symbol: SPTBN2
Alias: SCA5
Full Name: spectrin beta, non-erythrocytic 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 46,742 bases
Position: chr11:66,682,496-66,729,237
Accession: 11276
RBP type: non-canonical RBP
Summary: Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements. [provided by RefSeq, Dec 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000309996	SPTBN2-201	7866	XM_006718669	ENSP00000311489	2390 (aa)	XP_006718732	O15020
ENST00000527010	SPTBN2-202	859	-	ENSP00000433631	117 (aa)	-	E9PJZ2
ENST00000530665	SPTBN2-205	462	-	-	- (aa)	-	-
ENST00000647510	SPTBN2-212	8323	-	-	- (aa)	-	-
ENST00000530775	SPTBN2-206	473	-	-	- (aa)	-	-
ENST00000528051	SPTBN2-203	573	-	-	- (aa)	-	-
ENST00000611817	SPTBN2-210	2890	-	ENSP00000480692	934 (aa)	-	A4QPE4
ENST00000532650	SPTBN2-207	571	-	-	- (aa)	-	-
ENST00000617502	SPTBN2-211	3498	-	ENSP00000482000	934 (aa)	-	A4QPE4
ENST00000532902	SPTBN2-208	573	-	-	- (aa)	-	-
ENST00000529997	SPTBN2-204	8085	-	ENSP00000433593	2365 (aa)	-	O15020
ENST00000533211	SPTBN2-209	8128	XM_005274192	ENSP00000432568	2390 (aa)	XP_005274249	O15020

Gene Model

Click here to download ENSG00000173898's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000173898	rs55908905	11	66710394	A	Breast cancer	29059683	[0.018-0.046] unit increase	0.032	EFO_0000305

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000173898's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000165	MAPK cascade	-	TAS	Process
GO:0003779	actin binding	-	IEA	Function
GO:0005200	structural constituent of cytoskeleton	9826670.	TAS	Function
GO:0005543	phospholipid binding	-	IEA	Function
GO:0005615	extracellular space	22664934.	HDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006888	ER to Golgi vesicle-mediated transport	-	TAS	Process
GO:0007010	cytoskeleton organization	-	IEA	Process
GO:0007411	axon guidance	-	TAS	Process
GO:0007416	synapse assembly	-	IEA	Process
GO:0008091	spectrin	9826670.	IDA	Component
GO:0016192	vesicle-mediated transport	9826670.	IDA	Process
GO:0016324	apical plasma membrane	-	IEA	Component
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	-	TAS	Process
GO:0021692	cerebellar Purkinje cell layer morphogenesis	-	IEA	Process
GO:0030054	cell junction	-	IDA	Component
GO:0030534	adult behavior	-	IEA	Process
GO:0035264	multicellular organism growth	-	IEA	Process
GO:0043025	neuronal cell body	-	IEA	Component
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0051693	actin filament capping	-	IEA	Process
GO:0098688	parallel fiber to Purkinje cell synapse	-	IEA	Component
GO:0098793	presynapse	-	IEA	Component
GO:0098918	structural constituent of synapse	-	IEA	Function
GO:0098978	glutamatergic synapse	-	IEA	Component
GO:0099173	postsynapse organization	-	IEA	Process
GO:0099189	postsynaptic spectrin-associated cytoskeleton	-	IEA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.