EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28339043	High ATP2A2 expression correlates with better prognosis of diffuse astrocytic tumor patients.	Oncol Rep	2017 May	Li WQ	doi: 10.3892/or.2017.5528
26608678	Small molecule RL71 targets SERCA2 at a novel site in the treatment of human colorectal cancer.	Oncotarget	2015 Nov 10	Yang B	doi: 10.18632/oncotarget.6068.
26607901	Curcumin induces apoptosis by inhibiting sarco/endoplasmic reticulum Ca2+ ATPase activity in ovarian cancer cells.	Cancer Lett	2016 Feb 1	Seo JA	doi: 10.1016/j.canlet.2015.11.021
17116488	Alterations in the ATP2A2 gene in correlation with colon and lung cancer.	Cancer Genet Cytogenet	2006 Dec	Korosec B	-
28174265	SGK3 sustains ERα signaling and drives acquired aromatase inhibitor resistance through maintaining endoplasmic reticulum homeostasis.	Proc Natl Acad Sci U S A	2017 Feb 21	Wang Y	doi: 10.1073/pnas.1612991114

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr12	110346257	In_Frame_Del	novel	S973del	0.41
ACC	chr12	110350225	3'Flank	novel		0.1
ACC	chr12	110327761	Missense_Mutation	rs746309999	N280S	0.48
BLCA	chr12	110345257	Silent	novel	F872F	0.33
BLCA	chr12	110346043	Silent	novel	E928E	0.34
BLCA	chr12	110345470	Intron	novel		0.33
BLCA	chr12	110282789	Missense_Mutation	NA	I71M	0.26
BLCA	chr12	110346269	Silent	novel	V976V	0.13
BLCA	chr12	110281893	Missense_Mutation	novel	R35T	0.15
BLCA	chr12	110339551	Missense_Mutation	novel	S531R	0.54
BLCA	chr12	110346275	Silent	rs767331508	L978L	0.08
BLCA	chr12	110345281	Silent	NA	P880P	0.29
BLCA	chr12	110327741	Silent	novel	I273I	0.19
BLCA	chr12	110345343	Missense_Mutation	novel	S901C	0.13
BLCA	chr12	110345464	Intron	novel		0.44
BLCA	chr12	110346106	Silent	novel	V949V	0.49
BLCA	chr12	110339561	Frame_Shift_Del	novel	*P535Lfs2**	0.58
BLCA	chr12	110344939	Missense_Mutation	novel	D859N	0.57
BLCA	chr12	110296713	Missense_Mutation	novel	P147A	0.39
BLCA	chr12	110339580	Silent	novel	V540V	0.15
BLCA	chr12	110340927	Missense_Mutation	NA	R677P	0.29
BRCA	chr12	110346366	Missense_Mutation	novel	A1009T	0.07
BRCA	chr12	110343358	Silent	novel	I815I	0.05
BRCA	chr12	110340668	Missense_Mutation	NA	T591A	0.39
BRCA	chr12	110346522	3'UTR	novel		0.13
BRCA	chr12	110343374	Missense_Mutation	NA	R821W	0.15
BRCA	chr12	110343353	Missense_Mutation	NA	D814N	0.26
BRCA	chr12	110350006	3'Flank	novel		0.33
BRCA	chr12	110342431	Silent	NA	N767N	0.41
CESC	chr12	110327670	Nonsense_Mutation	novel	Q250*	0.31
CESC	chr12	110343401	Missense_Mutation	rs763393717	G830R	0.22
CESC	chr12	110334059	Silent	rs747229006	L445L	0.16
CESC	chr12	110281766	5'UTR	novel		0.39
CESC	chr12	110334037	Missense_Mutation	novel	G438A	0.24
CESC	chr12	110296728	Missense_Mutation	NA	E152Q	0.19
CESC	chr12	110346709	3'UTR	novel		0.57
CESC	chr12	110340783	Missense_Mutation	NA	G629D	0.28
CESC	chr12	110344962	Missense_Mutation	rs538399392	F866L	0.45
COAD	chr12	110350068	3'Flank	novel		0.43
COAD	chr12	110327922	Nonsense_Mutation	novel	R334*	0.49
COAD	chr12	110340965	Missense_Mutation	novel	L690I	0.14
COAD	chr12	110340761	Missense_Mutation	novel	M622V	0.09
COAD	chr12	110282778	Missense_Mutation	novel	A68T	0.15
COAD	chr12	110327664	Missense_Mutation	NA	P248S	0.48
COAD	chr12	110327593	Missense_Mutation	NA	V224A	0.19
COAD	chr12	110334072	Missense_Mutation	novel	E450Q	0.27
COAD	chr12	110340926	Nonsense_Mutation	novel	R677*	0.5
COAD	chr12	110327907	Frame_Shift_Del	NA	*N330Mfs55**	0.41
COAD	chr12	110339356	Missense_Mutation	NA	T499A	0.1
COAD	chr12	110345328	Missense_Mutation	novel	M896T	0.08
COAD	chr12	110345381	Missense_Mutation	NA	S914C	0.49
COAD	chr12	110296623	Missense_Mutation	NA	E117K	0.11
COAD	chr12	110346107	Missense_Mutation	rs773978831	E950K	0.39
COAD	chr12	110296623	Missense_Mutation	NA	E117K	0.3
COAD	chr12	110340752	Missense_Mutation	NA	R619W	0.26
COAD	chr12	110346394	Frame_Shift_Ins	novel	*I1027Cfs4**	0.37
COAD	chr12	110343378	Missense_Mutation	NA	N822S	0.33
COAD	chr12	110346337	Missense_Mutation	novel	Q999R	0.27
ESCA	chr12	110339368	Missense_Mutation	novel	P503S	0.66
ESCA	chr12	110339689	Missense_Mutation	novel	L577F	0.12
ESCA	chr12	110339521	Missense_Mutation	novel	I521F	0.35
ESCA	chr12	110346709	3'UTR	novel		0.56
GBM	chr12	110296623	Missense_Mutation	NA	E117K	0.18
GBM	chr12	110326475	Splice_Region	novel	S210S	0.5
GBM	chr12	110342280	Frame_Shift_Ins	novel	*I717Mfs11**	0.09
GBM	chr12	110342231	Missense_Mutation	novel	G701S	0.14
GBM	chr12	110350308	3'Flank	rs76586905		0.47
GBM	chr12	110344896	Silent	rs755978643	G844G	0.07
HNSC	chr12	110345247	Splice_Site	novel	X870_splice	0.2
HNSC	chr12	110342319	Missense_Mutation	novel	S730C	0.17
HNSC	chr12	110342424	Missense_Mutation	NA	S765L	0.63
HNSC	chr12	110346006	Missense_Mutation	NA	S916F	0.27
HNSC	chr12	110346007	Silent	rs144955024	S916S	0.27
HNSC	chr12	110326429	Missense_Mutation	novel	P195L	0.16
HNSC	chr12	110345997	Splice_Region	novel		0.32
HNSC	chr12	110346425	Missense_Mutation	novel	W1028C	0.16
HNSC	chr12	110350308	3'Flank	rs76586905		0.08
HNSC	chr12	110350308	3'Flank	novel		0.18
KIRC	chr12	110296729	Missense_Mutation	NA	E152V	0.21
KIRC	chr12	110346059	Missense_Mutation	NA	G934R	0.25
KIRC	chr12	110282622	Splice_Site	NA	X46_splice	0.42
KIRC	chr12	110339707	In_Frame_Ins	novel	F583delinsSNV	0.15
KIRP	chr12	110327673	Frame_Shift_Del	novel	*Q251Kfs3**	0.26
KIRP	chr12	110323008	Silent	novel	P160P	0.32
LAML	chr12	110345866	Intron	novel		0.33
LAML	chr12	110327647	Missense_Mutation	NA	T242I	0.32
LGG	chr12	110350351	3'Flank	novel		0.4
LGG	chr12	110323000	Missense_Mutation	novel	K158E	0.22
LGG	chr12	110326389	Splice_Site	novel	X182_splice	0.21
LGG	chr12	110342334	Missense_Mutation	NA	A735V	0.38
LGG	chr12	110345368	Silent	novel	C909C	0.09
LGG	chr12	110346267	Missense_Mutation	novel	V976M	0.34
LGG	chr12	110350308	3'Flank	rs76586905		0.29
LIHC	chr12	110281808	Missense_Mutation	novel	K7Q	0.39
LIHC	chr12	110340911	Missense_Mutation	novel	A672S	0.38
LIHC	chr12	110340968	Nonsense_Mutation	novel	Q691*	0.27
LIHC	chr12	110327856	Missense_Mutation	novel	P312S	0.16
LIHC	chr12	110344897	In_Frame_Del	novel	T847_A851del	0.25
LIHC	chr12	110350210	3'Flank	novel		0.16
LIHC	chr12	110350212	3'Flank	novel		0.16
LIHC	chr12	110345518	Intron	novel		0.23
LUAD	chr12	110327692	Missense_Mutation	novel	G257E	0.71
LUAD	chr12	110345907	Intron	novel		0.37
LUAD	chr12	110339283	Splice_Region	novel	V474V	0.2
LUAD	chr12	110345863	Intron	novel		0.17
LUAD	chr12	110327971	Missense_Mutation	novel	S350L	0.23
LUAD	chr12	110339333	Missense_Mutation	NA	R491K	0.17
LUAD	chr12	110323061	Missense_Mutation	NA	S178L	0.16
LUAD	chr12	110339585	Frame_Shift_Del	novel	*K543Dfs10**	0.15
LUAD	chr12	110346282	Missense_Mutation	NA	E981K	0.28
LUAD	chr12	110340881	Missense_Mutation	NA	P662S	0.18
LUAD	chr12	110327673	Missense_Mutation	novel	Q251K	0.06
LUAD	chr12	110327834	Silent	novel	V304V	0.16
LUAD	chr12	110345338	Silent	rs117494432	A899A	0.08
LUAD	chr12	110342326	Missense_Mutation	rs756804449	M732I	0.67
LUAD	chr12	110346006	Missense_Mutation	NA	S916F	0.14
LUSC	chr12	110343300	Missense_Mutation	novel	L796P	0.07
LUSC	chr12	110345504	Intron	novel		0.24
LUSC	chr12	110346033	Missense_Mutation	NA	P925R	0.4
LUSC	chr12	110342412	Missense_Mutation	novel	R761L	0.22
LUSC	chr12	110350362	3'Flank	novel		0.41
LUSC	chr12	110292068	Nonsense_Mutation	novel	E90*	0.49
LUSC	chr12	110292107	Missense_Mutation	rs376143339	I103V	0.18
LUSC	chr12	110345942	Intron	novel		0.15
LUSC	chr12	110340929	Missense_Mutation	novel	V678F	0.14
LUSC	chr12	110346453	Missense_Mutation	rs746403445	D1038N	0.19
LUSC	chr12	110343357	Missense_Mutation	novel	I815N	0.28
LUSC	chr12	110346085	Silent	novel	L942L	0.27
LUSC	chr12	110342366	Missense_Mutation	novel	V746F	0.38
OV	chr12	110346111	Missense_Mutation	novel	P951R	0.06
OV	chr12	110282792	Silent	NA	S72S	1
OV	chr12	110343327	Missense_Mutation	novel	A805V	0.05
OV	chr12	110345299	Silent	NA	D886D	0.23
OV	chr12	110350308	3'Flank	novel		0.32
OV	chr12	110340723	Missense_Mutation	NA	S609Y	0.24
OV	chr12	110339647	Silent	novel	L563L	0.09
OV	chr12	110346586	3'UTR	novel		0.37
OV	chr12	110346260	Silent	novel	S973S	0.38
PAAD	chr12	110327580	Missense_Mutation	rs771912488	M220V	0.04
PAAD	chr12	110327710	Missense_Mutation	novel	V263A	0.03
PAAD	chr12	110340692	Silent	rs771429870	L599L	0.2
PAAD	chr12	110346364	Missense_Mutation	rs151157805	S1008L	0.28
PAAD	chr12	110346422	Silent	novel	I1027I	0.28
PRAD	chr12	110327579	Silent	NA	A219A	0.28
PRAD	chr12	110339393	Frame_Shift_Ins	novel	*F512Vfs7**	0.23
READ	chr12	110327613	Missense_Mutation	rs748353664	E231K	0.21
READ	chr12	110346418	Missense_Mutation	novel	V1026A	0.21
READ	chr12	110340959	Nonsense_Mutation	NA	E688*	0.18
READ	chr12	110346019	Silent	novel	S920S	0.44
SARC	chr12	110346499	3'UTR	rs764675759		0.35
SARC	chr12	110332602	Missense_Mutation	novel	F367L	0.38
SARC	chr12	110346956	3'UTR	novel		0.3
SKCM	chr12	110323007	Missense_Mutation	NA	P160L	0.38
SKCM	chr12	110346391	Missense_Mutation	novel	P1017L	0.1
SKCM	chr12	110333219	Missense_Mutation	NA	D408G	0.29
SKCM	chr12	110346358	Missense_Mutation	rs370067725	S1006L	0.4
SKCM	chr12	110346049	Silent	NA	I930I	0.33
SKCM	chr12	110327930	Silent	novel	L336L	0.34
SKCM	chr12	110344966	Nonsense_Mutation	NA	Q868*	0.1
SKCM	chr12	110340954	Missense_Mutation	NA	I686S	0.14
SKCM	chr12	110344958	Missense_Mutation	novel	S865F	0.67
SKCM	chr12	110344959	Silent	novel	S865S	0.67
SKCM	chr12	110340709	Silent	rs774721089	I604I	0.28
SKCM	chr12	110340699	Missense_Mutation	NA	P601L	0.07
SKCM	chr12	110340820	Silent	rs779387152	F641F	0.11
SKCM	chr12	110281847	Missense_Mutation	NA	E20K	0.44
SKCM	chr12	110327553	Missense_Mutation	NA	G211S	0.31
SKCM	chr12	110340906	Missense_Mutation	NA	L670R	0.22
SKCM	chr12	110339651	Missense_Mutation	novel	A564V	0.59
SKCM	chr12	110339652	Silent	novel	A564A	0.6
SKCM	chr12	110281903	Silent	NA	S38S	0.35
SKCM	chr12	110343416	Missense_Mutation	NA	R835C	0.41
SKCM	chr12	110343260	Missense_Mutation	novel	P783S	0.36
SKCM	chr12	110350283	3'Flank	novel		0.21
SKCM	chr12	110344962	Silent	NA	F866F	0.24
SKCM	chr12	110346266	Silent	rs147558863	P975P	0.52
SKCM	chr12	110345486	Intron	novel		0.5
SKCM	chr12	110350298	3'Flank	novel		0.16
SKCM	chr12	110343415	Silent	NA	F834F	0.42
SKCM	chr12	110346259	Missense_Mutation	NA	S973F	0.46
SKCM	chr12	110346459	Missense_Mutation	NA	F1040L	0.26
SKCM	chr12	110327782	Missense_Mutation	novel	S287F	0.08
SKCM	chr12	110340698	Missense_Mutation	novel	P601S	0.08
SKCM	chr12	110340965	Missense_Mutation	novel	L690I	0.24
STAD	chr12	110296607	Silent	NA	N111N	0.07
STAD	chr12	110327554	Missense_Mutation	novel	G211D	0.13
STAD	chr12	110332661	Missense_Mutation	NA	S387L	0.19
STAD	chr12	110350332	3'Flank	novel		0.25
STAD	chr12	110342315	Missense_Mutation	NA	A729T	0.29
STAD	chr12	110350344	3'Flank	rs149534855		0.29
STAD	chr12	110339573	Missense_Mutation	novel	S538Y	0.23
STAD	chr12	110350362	3'Flank	novel		0.15
STAD	chr12	110340739	Silent	NA	R614R	0.48
STAD	chr12	110345334	Missense_Mutation	NA	M898T	0.24
STAD	chr12	110350251	3'Flank	novel		0.24
STAD	chr12	110343375	Missense_Mutation	rs778998667	R821Q	0.14
THCA	chr12	110333216	Missense_Mutation	NA	Y407C	0.38
UCEC	chr12	110340673	Silent	rs778396057	F592F	0.34
UCEC	chr12	110340811	Silent	novel	I638I	0.09
UCEC	chr12	110347361	3'Flank	novel		0.27
UCEC	chr12	110347133	3'UTR	novel		0.11
UCEC	chr12	110343432	Missense_Mutation	novel	G840D	0.41
UCEC	chr12	110282603	Splice_Site	novel	X40_splice	0.4
UCEC	chr12	110344941	Silent	rs139307921	D859D	0.47
UCEC	chr12	110332615	Missense_Mutation	novel	V372L	0.56
UCEC	chr12	110339507	Missense_Mutation	novel	A516D	0.49
UCEC	chr12	110340813	Missense_Mutation	novel	G639D	0.36
UCEC	chr12	110327689	Missense_Mutation	NA	F256C	0.32
UCEC	chr12	110346392	Silent	rs746737827	P1017P	0.46
UCEC	chr12	110350056	3'Flank	novel		0.15
UCEC	chr12	110327620	Missense_Mutation	NA	G233D	0.36
UCEC	chr12	110326434	Missense_Mutation	novel	P197S	0.19
UCEC	chr12	110346107	Nonsense_Mutation	NA	E950*	0.26
UCEC	chr12	110339321	Missense_Mutation	NA	F487C	0.37
UCEC	chr12	110346765	3'UTR	novel		0.38
UCEC	chr12	110327595	Missense_Mutation	novel	A225S	0.33
UCEC	chr12	110350241	3'Flank	rs772775565		0.39
UCEC	chr12	110345382	Missense_Mutation	novel	S914I	0.19
UCEC	chr12	110346023	Silent	novel	L922L	0.32
UCEC	chr12	110346765	3'UTR	novel		0.41
UCEC	chr12	110347347	3'Flank	novel		0.38
UCEC	chr12	110350434	3'Flank	novel		0.29
UCEC	chr12	110350529	3'Flank	novel		0.07
UCEC	chr12	110346513	3'UTR	novel		0.42
UCEC	chr12	110333178	Splice_Region	novel		0.52
UCEC	chr12	110340752	Missense_Mutation	NA	R619W	0.33
UCEC	chr12	110340875	Missense_Mutation	NA	L660F	0.33
UCEC	chr12	110342315	Missense_Mutation	NA	A729T	0.06
UCEC	chr12	110346709	3'UTR	novel		0.37
UCEC	chr12	110340709	Silent	rs774721089	I604I	0.48
UCEC	chr12	110346098	Missense_Mutation	novel	L947I	0.47
UCEC	chr12	110350236	3'Flank	novel		0.43
UCEC	chr12	110340995	Splice_Site	NA	X699_splice	0.3
UCEC	chr12	110345982	Intron	novel		0.38
UCEC	chr12	110340807	Missense_Mutation	rs753907244	R637H	0.44
UCEC	chr12	110327966	Frame_Shift_Del	novel	*C349Kfs17**	0.39
UCEC	chr12	110343376	Silent	novel	R821R	0.49
UCEC	chr12	110346287	Silent	rs755788872	T982T	0.46
UCEC	chr12	110340687	Missense_Mutation	novel	G597D	0.38
UCEC	chr12	110345921	Intron	novel		0.34
UCEC	chr12	110350420	3'Flank	novel		0.32
UCEC	chr12	110296623	Missense_Mutation	NA	E117K	0.37
UCEC	chr12	110339290	Missense_Mutation	novel	Q477K	0.07
UCEC	chr12	110340860	Missense_Mutation	novel	R655W	0.3
UCEC	chr12	110343314	Silent	NA	L801L	0.51
UCEC	chr12	110346667	3'UTR	novel		0.36
UCEC	chr12	110339586	Missense_Mutation	novel	Q542H	0.43
UCEC	chr12	110350008	3'Flank	novel		0.45
UCEC	chr12	110346514	3'UTR	rs779495632		0.5
UCEC	chr12	110340955	Silent	rs140766323	I686I	0.37
UCEC	chr12	110347279	3'UTR	novel		0.19
UCEC	chr12	110334012	Missense_Mutation	rs767974635	A430T	0.2
UCEC	chr12	110347205	3'UTR	novel		0.27
UCEC	chr12	110350396	3'Flank	novel		0.19
UCEC	chr12	110342315	Missense_Mutation	NA	A729T	0.28
UCEC	chr12	110345994	Splice_Region	novel		0.33
UCEC	chr12	110327969	Frame_Shift_Del	novel	*S350Qfs35**	0.68
UCEC	chr12	110327970	Missense_Mutation	novel	S350A	0.68
UCEC	chr12	110334061	Missense_Mutation	novel	T446I	0.43
UCEC	chr12	110346514	3'UTR	rs779495632		0.49
UCEC	chr12	110340916	Silent	novel	R673R	0.27
UCEC	chr12	110346502	3'UTR	novel		0.29
UCEC	chr12	110327829	Missense_Mutation	novel	A303T	0.3
UCEC	chr12	110340699	Missense_Mutation	novel	P601H	0.3
UCEC	chr12	110343262	Silent	rs372888486	P783P	0.37
UCEC	chr12	110334109	Missense_Mutation	novel	L462H	0.29
UCEC	chr12	110350526	3'Flank	novel		0.08
UCEC	chr12	110350527	3'Flank	novel		0.09
UCEC	chr12	110334025	Missense_Mutation	novel	Y434C	0.33
UCEC	chr12	110339634	Silent	novel	L558L	0.27
UCEC	chr12	110350308	3'Flank	rs76586905		0.32
UCEC	chr12	110340860	Missense_Mutation	novel	R655W	0.44
UCEC	chr12	110327679	Missense_Mutation	novel	L253I	0.39

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.0222	0.20414
CHOL	DEL	0.2222	0.067545
HNSC	DEL	0.0594	0.22646
LUAD	DEL	0.1395	0.0059643
LUSC	DEL	0.0898	0.038823
PAAD	DEL	0.1793	0.0030251
PRAD	AMP	0.0569	0.016187
SKCM	DEL	0.1935	0.00079981

Survival Analysis

Cancer	P-value	Q-value
MESO	0.0051	Kaplan-Meier Survival Analysis
ACC	0.044	Kaplan-Meier Survival Analysis
HNSC	0.013	Kaplan-Meier Survival Analysis
SKCM	0.012	Kaplan-Meier Survival Analysis
BRCA	0.026	Kaplan-Meier Survival Analysis
CESC	0.04	Kaplan-Meier Survival Analysis
UCEC	0.04	Kaplan-Meier Survival Analysis
LUAD	0.028	Kaplan-Meier Survival Analysis
UVM	0.00044	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000174437 (Gene tree)
Gene ID: 488
Gene Symbol: ATP2A2
Alias: SERCA2|ATP2B|DAR
Full Name: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 70,338 bases
Position: chr12:110,280,756-110,351,093
Accession: 812
RBP type: non-canonical RBP
Summary: This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
11677214	Altered cellular calcium regulatory systems in a rat model of cirrhotic cardiomyopathy.	Gastroenterology	2001 Nov	Ward CA	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000313432	ATP2A2-202	5575	-	-	- (aa)	-	-
ENST00000547792	ATP2A2-206	541	-	-	- (aa)	-	-
ENST00000547050	ATP2A2-205	1176	-	-	- (aa)	-	-
ENST00000553144	ATP2A2-212	264	-	ENSP00000450407	46 (aa)	-	A0A0C4DH86
ENST00000539276	ATP2A2-204	4094	XM_005253888	ENSP00000440045	1042 (aa)	XP_005253945	P16615
ENST00000550262	ATP2A2-210	3670	-	-	- (aa)	-	-
ENST00000308664	ATP2A2-201	4453	-	ENSP00000311186	997 (aa)	-	P16615
ENST00000549840	ATP2A2-208	503	-	-	- (aa)	-	-
ENST00000552636	ATP2A2-211	529	-	ENSP00000447406	44 (aa)	-	F8W1Z7
ENST00000377685	ATP2A2-203	5702	-	ENSP00000366913	50 (aa)	-	J3QSY6
ENST00000548169	ATP2A2-207	2951	-	ENSP00000449454	933 (aa)	-	H7C5W9
ENST00000550248	ATP2A2-209	544	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000174437's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04020	Calcium signaling pathway	KEGG
hsa04022	cGMP-PKG signaling pathway	KEGG
hsa04024	cAMP signaling pathway	KEGG
hsa04260	Cardiac muscle contraction	KEGG
hsa04261	Adrenergic signaling in cardiomyocytes	KEGG
hsa04919	Thyroid hormone signaling pathway	KEGG
hsa04972	Pancreatic secretion	KEGG
hsa05010	Alzheimer disease	KEGG
hsa05410	Hypertrophic cardiomyopathy (HCM)	KEGG
hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	KEGG
hsa05414	Dilated cardiomyopathy (DCM)	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000174437	Glucose	7E-6	25524916
ENSG00000174437	Insulin	7E-6	25524916
ENSG00000174437	Schizophrenia	1E-9	25056061
ENSG00000174437	Electrocardiography	3E-12	24952745
ENSG00000174437	Schizophrenia	2E-10	26198764

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000174437	rs4766428	12	110285440	T	Schizophrenia	25056061	[1.045-1.091]	1.068	EFO_0000692
ENSG00000174437	rs3026445	12	110285398	C	QT interval	24952745	[0.44-0.8] unit increase	0.62	EFO_0004682
ENSG00000174437	rs3026485	12	110344222	?	Glucose homeostasis traits	25524916	[5.32-25.16] unit increase	15.24	EFO_0006896\|EFO_0006831
ENSG00000174437	rs4766428	12	110285440	T	Schizophrenia	26198764	[NR]	1.07	EFO_0000692
ENSG00000174437	rs4766428	12	110285440	T	Schizophrenia	28991256	[1.04-1.09]	1.065	EFO_0000692
ENSG00000174437	rs4766428	12	110285440	?	Schizophrenia	29483656	[1.06-1.10]	1.0787487	EFO_0000692
ENSG00000174437	rs4766428	12	110285440	T	Schizophrenia	30285260	[1.05-1.09]	1.0719	EFO_0000692
ENSG00000174437	rs4766428	12	110285440	T	Schizophrenia	30285260	[1.05-1.09]	1.07	EFO_0000692

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000174437's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000174437	ATP2A2	100	98.898	ENSMUSG00000029467	Atp2a2	100	98.898	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002026	regulation of the force of heart contraction	-	IEA	Process
GO:0003009	skeletal muscle contraction	-	IEA	Process
GO:0005388	calcium-transporting ATPase activity	21873635.	IBA	Function
GO:0005388	calcium-transporting ATPase activity	16402920.	IDA	Function
GO:0005509	calcium ion binding	16402920.	IDA	Function
GO:0005515	protein binding	17526652.20528919.22084111.24764305.25996873.28298427.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005783	endoplasmic reticulum	16081076.	IDA	Component
GO:0005789	endoplasmic reticulum membrane	11402072.	IDA	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0005887	integral component of plasma membrane	2844796.	TAS	Component
GO:0006874	cellular calcium ion homeostasis	21873635.	IBA	Process
GO:0006984	ER-nucleus signaling pathway	-	IEA	Process
GO:0006996	organelle organization	-	IEA	Process
GO:0007155	cell adhesion	10080178.	TAS	Process
GO:0008544	epidermis development	10080178.	TAS	Process
GO:0008553	proton-exporting ATPase activity, phosphorylative mechanism	21873635.	IBA	Function
GO:0010460	positive regulation of heart rate	22679139.	TAS	Process
GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling	21873635.	IBA	Process
GO:0012506	vesicle membrane	-	IEA	Component
GO:0014883	transition between fast and slow fiber	-	IEA	Process
GO:0014898	cardiac muscle hypertrophy in response to stress	-	IEA	Process
GO:0016020	membrane	22375059.	IDA	Component
GO:0016529	sarcoplasmic reticulum	12804600.	IDA	Component
GO:0019899	enzyme binding	21903937.	IPI	Function
GO:0031095	platelet dense tubular network membrane	-	TAS	Component
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	-	IEA	Component
GO:0031775	lutropin-choriogonadotropic hormone receptor binding	-	IEA	Function
GO:0032469	endoplasmic reticulum calcium ion homeostasis	16402920.	IDA	Process
GO:0032470	positive regulation of endoplasmic reticulum calcium ion concentration	16402920.	IDA	Process
GO:0032496	response to lipopolysaccharide	-	IEA	Process
GO:0032991	protein-containing complex	-	IEA	Component
GO:0033017	sarcoplasmic reticulum membrane	21873635.	IBA	Component
GO:0033017	sarcoplasmic reticulum membrane	19095005.	TAS	Component
GO:0033292	T-tubule organization	-	IEA	Process
GO:0034220	ion transmembrane transport	-	TAS	Process
GO:0034599	cellular response to oxidative stress	-	IEA	Process
GO:0034605	cellular response to heat	-	IEA	Process
GO:0034976	response to endoplasmic reticulum stress	-	ISS	Process
GO:0044548	S100 protein binding	12804600.	IPI	Function
GO:0045822	negative regulation of heart contraction	-	IEA	Process
GO:0048471	perinuclear region of cytoplasm	-	IEA	Component
GO:0055119	relaxation of cardiac muscle	-	IEA	Process
GO:0061831	apical ectoplasmic specialization	-	IEA	Component
GO:0070296	sarcoplasmic reticulum calcium ion transport	19095005.22679139.	TAS	Process
GO:0070588	calcium ion transmembrane transport	21873635.	IBA	Process
GO:0070588	calcium ion transmembrane transport	16402920.	IDA	Process
GO:0086036	regulation of cardiac muscle cell membrane potential	16402920.	IC	Process
GO:0086036	regulation of cardiac muscle cell membrane potential	-	ISS	Process
GO:0086036	regulation of cardiac muscle cell membrane potential	22679139.	TAS	Process
GO:0086039	calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential	21873635.	IBA	Function
GO:0086039	calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential	16402920.	IC	Function
GO:0086039	calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential	-	ISS	Function
GO:0086039	calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential	22679139.	TAS	Function
GO:0097470	ribbon synapse	-	IEA	Component
GO:0098909	regulation of cardiac muscle cell action potential involved in regulation of contraction	-	ISS	Process
GO:0099132	ATP hydrolysis coupled cation transmembrane transport	-	IEA	Process
GO:0120025	plasma membrane bounded cell projection	-	IEA	Component
GO:1902600	proton transmembrane transport	-	IEA	Process
GO:1903233	regulation of calcium ion-dependent exocytosis of neurotransmitter	-	IEA	Process
GO:1903515	calcium ion transport from cytosol to endoplasmic reticulum	16402920.	IDA	Process
GO:1903779	regulation of cardiac conduction	-	TAS	Process
GO:1990036	calcium ion import into sarcoplasmic reticulum	16402920.	IC	Process
GO:1990036	calcium ion import into sarcoplasmic reticulum	-	ISS	Process

EuRBPDB

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.