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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
24726882Induction of ATM/ATR pathway combined with Vγ2V??2 T cells enhances cytotoxicity of ovarian cancer cells.Biochim Biophys Acta2014 JulLu Jdoi: 10.1016/j.bbadis.2014.04.003
11865061Hypoxia links ATR and p53 through replication arrest.Mol Cell Biol2002 MarHammond EM-
22341969Germline mutation in ATR in autosomal- dominant oropharyngeal cancer syndrome.Am J Hum Genet2012 Mar 9Tanaka Adoi: 10.1016/j.ajhg.2012.01.007
15282542ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background.EMBO J2004 Aug 4Fang Y-
27693461Inhibition of ATR-dependent feedback activation of Chk1 sensitises cancer cells to Chk1 inhibitor monotherapy.Cancer Lett2016 Dec 1Massey AJdoi: 10.1016/j.canlet.2016.09.024
28273450ATR Mutations Promote the Growth of Melanoma Tumors by Modulating the Immune Microenvironment.Cell Rep2017 Mar 7Chen CFdoi: 10.1016/j.celrep.2017.02.040.
26748709Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities.Cell Rep2016 Jan 12Sanjiv Kdoi: 10.1016/j.celrep.2015.12.032
18625709ATR-dependent activation of p38 MAP kinase is responsible for apoptotic cell death in cells depleted of Cdc7.J Biol Chem2008 Sep 12Im JSdoi: 10.1074/jbc.M802851200
21308861Inhibition of ataxia telangiectasia- and Rad3-related function abrogates the in vitro and in vivo tumorigenicity of human colon cancer cells through depletion of the CD133(+) tumor-initiating cell fraction.Stem Cells2011 MarGallmeier Edoi: 10.1002/stem.595.
24752797Development of serous ovarian cancer is associated with the expression of homologous recombination pathway proteins.Pathol Oncol Res2014 OctYe Qdoi: 10.1007/s12253-014-9776-8
26755646A synthetic lethal screen identifies ATR-inhibition as a novel therapeutic approach for POLD1-deficient cancers.Oncotarget2016 Feb 9Hocke Sdoi: 10.18632/oncotarget.6857.
21034966The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer.Adv Cancer Res2010Smith Jdoi: 10.1016/B978-0-12-380888-2.00003-0.
20513533High incidence of mutations in BRCA1 and BRCA2 genes in ovarian cancer.Bull Exp Biol Med2007 JulSmirnova TY-
23548269Germline mutations of BRCA1 gene exon 11 are not associated with platinum response neither with survival advantage in patients with primary ovarian cancer: understanding the clinical importance of one of the biggest human exons. A study of the Tumor Bank Ovarian Cancer (TOC) Consortium.Tumour Biol2016 SepDimitrova D-
25468710Untangling the ATR-CHEK1 network for prognostication, prediction and therapeutic target validation in breast cancer.Mol Oncol2015 MarAbdel-Fatah TMdoi: 10.1016/j.molonc.2014.10.013
23844225Associations of ATR and CHEK1 single nucleotide polymorphisms with breast cancer.PLoS One2013 Jul 3Lin WYdoi: 10.1371/journal.pone.0068578
26486089Common cancer-associated imbalances in the DNA damage response confer sensitivity to single agent ATR inhibition.Oncotarget2015 Oct 20Middleton FKdoi: 10.18632/oncotarget.6136.
18642075Promoter methylation patterns of ATM, ATR, BRCA1, BRCA2 and p53 as putative cancer risk modifiers in Jewish BRCA1/BRCA2 mutation carriers.Breast Cancer Res Treat2009 JulKontorovich Tdoi: 10.1007/s10549-008-0121-3
23451157Ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase inhibition is synthetically lethal in XRCC1 deficient ovarian cancer cells.PLoS One2013Sultana Rdoi: 10.1371/journal.pone.0057098
26517239The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo.Oncotarget2015 Dec 29Vendetti FPdoi: 10.18632/oncotarget.6247.
23600770HY-1 induces G(2)/M cell cycle arrest in human colon cancer cells through the ATR-Chk1-Cdc25C and Weel pathways.Cancer Sci2013 AugZhao Ydoi: 10.1111/cas.12182
21383502Genomic DNA damage and ATR-Chk1 signaling determine oncolytic adenoviral efficacy in human ovarian cancer cells.J Clin Invest2011 AprConnell CMdoi: 10.1172/JCI43976
22435685Novel regulation of checkpoint kinase 1: Is checkpoint kinase 1 a good candidate for anti-cancer therapy?Cancer Sci2012 JulGoto Hdoi: 10.1111/j.1349-7006.2012.02280.x
26657501ATR-Chk1 signaling inhibition as a therapeutic strategy to enhance cisplatin chemosensitivity in urothelial bladder cancer.Oncotarget2016 Jan 12Li CCdoi: 10.18632/oncotarget.6482.
21566061Hsp90 inhibitor-mediated disruption of chaperone association of ATR with hsp90 sensitizes cancer cells to DNA damage.Mol Cancer Ther2011 JulHa Kdoi: 10.1158/1535-7163.MCT-11-0094
23284306A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient human cancer cells.PLoS Genet2012Xie Ldoi: 10.1371/journal.pgen.1003151
25336189Identification of ATR-Chk1 pathway inhibitors that selectively target p53-deficient cells without directly suppressing ATR catalytic activity.Cancer Res2014 Dec 15Kawasumi Mdoi: 10.1158/0008-5472.CAN-14-2650
19477925Estrogen inhibits ATR signaling to cell cycle checkpoints and DNA repair.Mol Biol Cell2009 JulPedram Adoi: 10.1091/mbc.E09-01-0085
15374968Inhibition of ATR leads to increased sensitivity to hypoxia/reoxygenation.Cancer Res2004 Sep 15Hammond EM-
25846551Profiling cancer gene mutations in longitudinal epithelial ovarian cancer biopsies by targeted next-generation sequencing: a retrospective study.Ann Oncol2015 JulBeltrame Ldoi: 10.1093/annonc/mdv164
28440428Inhibition of ATR potentiates the cytotoxic effect of gemcitabine on pancreatic cancer cells through enhancement of DNA damage and abrogation of ribonucleotide reductase induction by gemcitabine.Oncol Rep2017 JunLiu Sdoi: 10.3892/or.2017.5580
27472395IGF-1R inhibition sensitizes breast cancer cells to ATM-related kinase (ATR) inhibitor and cisplatin.Oncotarget2016 Aug 30O'Flanagan CHdoi: 10.18632/oncotarget.10862.
29378956ATR-Chk1 activation mitigates replication stress caused by mismatch repair-dependent processing of DNA damage.Proc Natl Acad Sci U S A2018 Feb 13Gupta Ddoi: 10.1073/pnas.1720355115
28017652ATR gene mutations in HPV negative oropharyngeal cancer.Oral Oncol2017 FebJeannon JPdoi: 10.1016/j.oraloncology.2016.12.009
29396668Targeting ataxia telangiectasia-mutated- and Rad3-related kinase (ATR) in PTEN-deficient breast cancers for personalized therapy.Breast Cancer Res Treat2018 JunAl-Subhi Ndoi: 10.1007/s10549-018-4683-4
28808232Analysis of the ATR-Chk1 and ATM-Chk2 pathways in male breast cancer revealed the prognostic significance of ATR expression.Sci Rep2017 Aug 14Di Benedetto Adoi: 10.1038/s41598-017-07366-7.
30532030Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition.Oncogene2019 AprWang Cdoi: 10.1038/s41388-018-0606-4

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr3142568087Missense_MutationnovelR43W0.52
ACCchr3142513591Missense_MutationnovelM1517I0.18
BLCAchr3142467996Missense_MutationnovelE2209Q0.47
BLCAchr3142459091Missense_MutationnovelY2457S0.28
BLCAchr3142450589Intronnovel0.1
BLCAchr3142519705Missense_MutationnovelH1449L0.49
BLCAchr3142549611SilentnovelL1013L0.41
BLCAchr3142513560Missense_MutationnovelL1528F0.13
BLCAchr3142515433Missense_MutationnovelE1489Q0.53
BLCAchr3142450799Intronnovel0.8
BLCAchr3142507967SilentNAK1665K0.16
BLCAchr3142496481Missense_MutationNAQ1926H0.47
BLCAchr3142512364Missense_MutationnovelS1583C0.04
BLCAchr3142469486Missense_MutationnovelP2135S0.12
BLCAchr3142449459Missense_MutationNAQ2635H0.16
BLCAchr3142451141Intronnovel0.21
BLCAchr3142462044Missense_Mutationrs142918229R2363Q0.44
BLCAchr3142561350Missense_MutationnovelQ414H0.49
BLCAchr3142470128Missense_MutationNAL2093V0.14
BLCAchr3142503393Missense_Mutationrs143806447I1753V0.53
BLCAchr3142540943Missense_MutationNAG1181V0.22
BLCAchr3142512420SilentNAI1564I0.23
BLCAchr3142547871Missense_MutationnovelD1071N0.22
BLCAchr3142452983Intronnovel0.4
BLCAchr3142465208Missense_MutationNAK2310N0.13
BLCAchr3142498610Missense_MutationnovelE1849Q0.25
BLCAchr3142462071Missense_MutationnovelE2354V0.09
BLCAchr3142538619Nonsense_MutationnovelW1196*0.33
BLCAchr3142469447Nonsense_MutationnovelR2148*0.14
BLCAchr3142503387Missense_MutationnovelQ1755E0.4
BLCAchr3142547837Missense_Mutationrs146504354R1082H0.12
BLCAchr3142496429Missense_MutationNAL1944F0.22
BLCAchr3142578667Missense_MutationnovelP13L0.52
BLCAchr3142451157Intronnovel0.19
BLCAchr3142553327Missense_MutationNAS902F0.25
BLCAchr3142540963Missense_MutationNAM1174I0.21
BLCAchr3142503387Missense_MutationnovelQ1755K0.3
BLCAchr3142469354Missense_MutationnovelM2179V0.19
BLCAchr3142542676Missense_MutationnovelD1147N0.13
BLCAchr3142449555Missense_MutationnovelI2603M0.43
BRCAchr3142566187Missense_MutationNAM76L0.17
BRCAchr3142451456Intronnovel0.32
BRCAchr3142450671Intronnovel0.18
BRCAchr3142556122Missense_MutationNAD699V0.18
BRCAchr3142451516Intronnovel0.32
BRCAchr3142515517Splice_SiteNAX1461_splice0.22
BRCAchr3142496495Nonsense_MutationnovelE1922*0.12
BRCAchr3142498686SilentnovelL1823L0.25
BRCAchr3142451327Intronnovel0.35
BRCAchr3142547901Missense_MutationNAE1061K0.17
BRCAchr3142453165Missense_Mutationrs762196224A2575V0.15
BRCAchr3142465140Missense_MutationnovelR2333T0.29
BRCAchr3142540910Missense_MutationnovelC1192Y0.2
BRCAchr3142496418SilentnovelA1947A0.18
BRCAchr3142512315SilentNAL1599L0.16
BRCAchr3142452170Intronnovel0.12
BRCAchr3142470098Missense_MutationnovelE2103K0.2
BRCAchr3142498637Missense_MutationnovelE1840Q0.07
BRCAchr3142451211Intronnovel0.4
BRCAchr3142512303Silentrs777880900K1603K0.16
BRCAchr3142453038Intronnovel0.44
BRCAchr3142555972Missense_MutationNAS749C0.17
BRCAchr3142459357Missense_Mutationrs746049210R2407C0.32
BRCAchr3142524043Nonsense_MutationNAR1368*0.14
BRCAchr3142540937Missense_Mutationrs780802796R1183Q0.27
BRCAchr3142457641Missense_MutationNAM2540V0.41
BRCAchr3142450216Intronnovel0.38
BRCAchr3142469489Missense_MutationNAA2134S0.43
BRCAchr3142566124Frame_Shift_DelnovelK93Nfs*20.1
BRCAchr3142450232Intronnovel0.36
BRCAchr3142503439In_Frame_DelnovelH1737del0.1
CESCchr3142470119Missense_MutationnovelD2096H0.07
CESCchr3142547820Missense_MutationNAQ1088E0.37
CESCchr3142499682SilentnovelV1775V0.2
CESCchr3142452949Intronnovel0.44
CESCchr3142555898Frame_Shift_Delrs757500301I774Yfs*50.48
CESCchr3142450387Intronnovel0.13
CESCchr3142553377Silentrs756012253V885V0.11
CESCchr3142562610Missense_MutationnovelQ264H0.12
CESCchr3142562612Nonsense_MutationnovelQ264*0.13
CESCchr3142462017Missense_MutationNAD2372A0.27
CESCchr3142459321Missense_MutationNAE2419K0.27
CESCchr3142465208Missense_MutationNAK2310N0.17
CESCchr3142550142Missense_Mutationrs558627427R989H0.43
CESCchr3142465318IntronNA0.17
CESCchr3142513587Nonsense_MutationnovelK1519*0.47
CESCchr3142496453Missense_MutationNAH1936Y0.24
CESCchr3142470179Missense_Mutationrs372864251L2076V0.23
CESCchr3142450518Intronnovel0.19
CHOLchr3142449484Missense_MutationnovelA2627V0.53
COADchr3142542698SilentNAL1139L0.33
COADchr3142512306Missense_MutationNAE1602D0.35
COADchr3142562872Missense_Mutationrs532495501R177Q0.42
COADchr3142566142Nonsense_MutationNAE91*0.37
COADchr31424494063'UTRnovel0.31
COADchr3142451336Intronnovel0.19
COADchr3142547901Nonsense_MutationnovelE1061*0.23
COADchr3142556102Nonsense_MutationNAE706*0.29
COADchr3142451047Intronnovel0.13
COADchr3142496429Missense_MutationNAL1944F0.23
COADchr3142450486Intronnovel0.41
COADchr3142542712Frame_Shift_InsnovelN1135*0.36
COADchr3142542759Splice_SitenovelX1120_splice0.45
COADchr3142568103SilentNAL37L0.36
COADchr3142553254Frame_Shift_InsNAS927Qfs*40.34
COADchr3142560440Missense_Mutationrs776069964D455G0.34
COADchr3142562396Missense_MutationNAR336W0.31
COADchr3142451402Intronnovel0.28
COADchr3142453164Silentrs587783340A2575A0.34
COADchr3142558666Missense_Mutationrs759350161A615T0.44
COADchr3142542684Missense_MutationNAG1144D0.39
COADchr3142503404Missense_MutationnovelL1749P0.15
COADchr3142451749Intronnovel0.5
COADchr3142562580Frame_Shift_InsnovelL274Ffs*130.34
COADchr3142512328Missense_MutationnovelK1595T0.2
COADchr3142536125Missense_MutationnovelL1268F0.15
COADchr3142538492Missense_MutationNAI1239L0.15
COADchr3142547850Nonsense_MutationNAE1078*0.13
COADchr31424494113'UTRnovel0.29
COADchr3142540978SilentnovelS1169S0.08
COADchr3142556093Frame_Shift_DelnovelS709Yfs*250.07
COADchr3142578685Missense_MutationNAE7V0.27
COADchr3142536191Nonsense_MutationNAQ1246*0.15
COADchr3142555920Missense_MutationnovelF766L0.42
COADchr3142496408Nonsense_Mutationrs758234545R1951*0.46
COADchr3142450295Intronnovel0.36
COADchr3142508062Missense_MutationnovelD1634N0.29
DLBCchr3142562442Missense_MutationnovelM320I0.34
ESCAchr31424493263'UTRnovel0.38
ESCAchr3142561298Missense_Mutationrs757006178R432C0.22
ESCAchr3142507975Missense_MutationnovelT1663A0.21
ESCAchr3142505276Missense_MutationNAD1687H0.1
ESCAchr3142553888SilentnovelA823A0.12
ESCAchr3142499645Nonsense_MutationnovelE1788*0.06
ESCAchr3142449465SilentnovelL2633L0.15
ESCAchr3142453214Missense_MutationnovelH2559N0.11
ESCAchr3142555898Frame_Shift_DelnovelK773Nfs*30.25
ESCAchr3142547740Frame_Shift_InsnovelS1115Ifs*30.33
GBMchr3142450652Intronnovel0.05
GBMchr3142493135SilentnovelY2025Y0.86
GBMchr3142515487Missense_MutationNAW1471R0.46
GBMchr3142459267Missense_MutationnovelH2437N0.35
GBMchr3142459268Missense_MutationnovelF2436L0.35
GBMchr3142561316Missense_MutationNAG426R0.36
GBMchr3142469430Silentrs374110291H2153H0.21
GBMchr3142458990Missense_Mutationrs556313656V2491I0.19
GBMchr3142522759Missense_Mutationrs371292374R1412Q0.19
GBMchr3142524043Nonsense_MutationNAR1368*0.47
GBMchr3142562872Missense_Mutationrs532495501R177Q0.19
GBMchr3142449431Nonstop_Mutationnovel*2645Rext*50.08
GBMchr3142451043Intronnovel0.14
GBMchr3142559268Missense_MutationnovelA572D0.14
GBMchr3142556110Missense_MutationnovelV703A0.08
GBMchr3142562758Missense_Mutationrs368507270R215H0.1
GBMchr3142562769Missense_MutationNAM211I0.05
GBMchr3142465147Missense_MutationNAD2331Y0.15
GBMchr3142540966SilentnovelK1173K0.11
HNSCchr3142465182Missense_MutationnovelG2319E0.24
HNSCchr3142513560Missense_MutationnovelL1528F0.05
HNSCchr3142513562Missense_MutationnovelY1527F0.06
HNSCchr3142563105Missense_MutationnovelF99L0.27
HNSCchr3142505285Missense_MutationnovelH1684D0.06
HNSCchr3142536200Missense_MutationnovelD1243H0.09
HNSCchr3142522761SilentnovelS1411S0.26
HNSCchr3142566231Missense_MutationnovelS61C0.09
HNSCchr3142457614Missense_MutationnovelP2549T0.52
HNSCchr3142559305Missense_MutationnovelE560K0.13
HNSCchr3142556498Frame_Shift_DelnovelT653Ffs*120.05
HNSCchr3142524102Missense_MutationnovelS1348F0.1
HNSCchr3142562665Missense_MutationnovelS246F0.09
HNSCchr3142559338Missense_MutationnovelS549C0.39
HNSCchr3142449454Missense_MutationNAY2637C0.15
HNSCchr3142457687SilentnovelG2524G0.25
HNSCchr3142556522Missense_MutationnovelI647L0.36
HNSCchr3142558731Missense_MutationnovelM593K0.38
HNSCchr3142566217Missense_Mutationrs758564083V66M0.16
HNSCchr3142457682Frame_Shift_DelnovelM2526Rfs*150.08
HNSCchr3142450553Intronnovel0.31
HNSCchr3142462014Missense_MutationnovelE2373V0.19
HNSCchr3142498757Missense_MutationnovelW1800R0.35
HNSCchr3142466423Missense_MutationnovelM2266I0.15
HNSCchr3142450351Intronnovel0.44
HNSCchr3142468025Missense_MutationnovelN2199S0.28
HNSCchr3142550149Missense_MutationnovelL987I0.18
KICHchr3142553823Splice_SitenovelX844_splice0.19
KIRCchr3142562367SilentNAA345A0.31
KIRCchr3142459050Missense_MutationNAL2471M0.22
KIRCchr3142449486Frame_Shift_DelnovelA2627Lfs*280.36
KIRCchr3142547763Frame_Shift_DelnovelY1107Ifs*120.29
KIRCchr3142459041Missense_MutationNAG2474R0.33
KIRCchr3142465177Missense_MutationNAF2321I0.59
KIRCchr3142450534Intronnovel0.63
KIRPchr3142555950SilentNAS756S0.36
KIRPchr3142549649Missense_MutationNAD1001Y0.48
KIRPchr3142566153Missense_MutationNAS87N0.19
LAMLchr3142553695Missense_MutationnovelS860T0.07
LGGchr3142519667Splice_SitenovelX1461_splice0.15
LGGchr3142505264Missense_MutationNAG1691R0.12
LGGchr3142562434Missense_MutationnovelE323G0.09
LGGchr3142449572Nonsense_MutationNAR2598*0.38
LGGchr3142450667Intronnovel0.29
LGGchr3142508048Missense_MutationnovelQ1638H0.1
LGGchr3142562255Missense_MutationnovelL383F0.38
LGGchr3142562609In_Frame_InsnovelQ264_P265insVF0.12
LIHCchr3142553289Missense_MutationnovelV915I0.21
LIHCchr3142513601Missense_MutationNAC1514F0.31
LIHCchr3142469493Silentrs774455552Y2132Y0.4
LIHCchr3142450446Intronnovel0.16
LIHCchr3142535120Missense_MutationNAH1302L0.51
LIHCchr3142562349Missense_MutationNAQ351H0.5
LIHCchr3142556409SilentNAS684S0.22
LIHCchr3142498775Splice_SiteNAX1794_splice0.3
LIHCchr3142497144SilentNAQ1869Q0.43
LIHCchr3142496474Missense_MutationnovelR1929W0.41
LIHCchr3142469397SilentnovelI2164I0.26
LIHCchr3142559409Missense_MutationnovelK525M0.27
LIHCchr3142469523Missense_MutationnovelI2122M0.46
LIHCchr3142549591Missense_MutationnovelQ1020L0.45
LIHCchr3142556391Missense_MutationNAK690N0.33
LIHCchr3142559250Splice_SitenovelX578_splice0.34
LIHCchr3142470154Frame_Shift_InsnovelY2084Lfs*130.3
LIHCchr3142560389Missense_Mutationrs752635785S472C0.4
LUADchr3142451840Intronnovel0.9
LUADchr3142553860Nonsense_MutationnovelE833*0.38
LUADchr3142536158Missense_MutationNAD1257H0.09
LUADchr3142452126Intronnovel0.33
LUADchr3142453154Missense_MutationNAE2579K0.29
LUADchr3142450724Intronnovel0.5
LUADchr3142562447Missense_MutationnovelN319Y0.38
LUADchr3142513591Missense_MutationNAM1517I0.25
LUADchr3142562240Missense_MutationNAD388N0.17
LUADchr3142553966Missense_MutationNAE797D0.25
LUADchr3142562828Missense_MutationnovelA192S0.09
LUADchr3142505239Missense_MutationNAE1699A0.49
LUADchr3142562628SilentnovelL258L0.14
LUADchr3142553280Missense_MutationNAK918E0.16
LUADchr3142524096Missense_MutationnovelA1350D0.09
LUADchr3142450354Intronnovel0.69
LUADchr3142562561Missense_MutationnovelV281L0.33
LUADchr3142466530Missense_MutationnovelD2231H0.08
LUADchr3142553360Missense_MutationnovelH891P0.36
LUADchr3142470152Nonsense_MutationnovelQ2085*0.22
LUADchr3142562375Nonsense_MutationnovelK343*0.32
LUADchr3142469446Missense_MutationNAR2148Q0.06
LUADchr3142538609Missense_MutationnovelV1200L0.1
LUADchr3142519743Silentrs539337477N1436N0.14
LUADchr3142451078Intronnovel0.26
LUADchr3142512421Frame_Shift_DelnovelV1555Efs*360.04
LUADchr3142451046Intronnovel0.31
LUADchr3142560432Missense_MutationnovelQ458K0.21
LUADchr3142556135Missense_MutationNAK695E0.37
LUADchr3142538582Missense_MutationnovelG1209C0.5
LUADchr3142538583SilentnovelL1208L0.5
LUADchr3142560282Frame_Shift_DelnovelS508Lfs*50.35
LUADchr3142449452Missense_MutationnovelL2638F0.18
LUADchr3142485248Missense_MutationnovelG2038E0.25
LUADchr3142553305SilentNAT909T0.89
LUSCchr31425787235'UTRnovel0.13
LUSCchr3142556008Missense_MutationnovelH737P0.08
LUSCchr3142524052Missense_MutationnovelD1365Y0.19
LUSCchr3142457633SilentnovelL2542L0.33
LUSCchr3142458964SilentnovelF2499F0.13
LUSCchr3142451120Intronnovel0.23
LUSCchr3142470083Splice_Regionnovel0.22
LUSCchr3142559412Missense_MutationnovelS524F0.24
LUSCchr3142550244Missense_MutationNAQ955R0.12
LUSCchr3142553286Missense_MutationNAA916P0.08
LUSCchr3142459026Missense_MutationNAE2479K0.25
LUSCchr3142469502Missense_MutationNAH2129Q0.46
LUSCchr3142561306Missense_MutationnovelP429L0.16
LUSCchr3142512265Nonsense_MutationnovelS1616*0.14
LUSCchr3142522829Missense_MutationnovelD1389N0.06
LUSCchr3142485271SilentnovelA2030A0.27
LUSCchr3142558646Missense_MutationnovelS621R0.15
LUSCchr3142459350Missense_MutationNAC2409S0.18
LUSCchr3142538564Missense_MutationNAV1215L0.38
LUSCchr3142555954Missense_MutationnovelS755F0.15
LUSCchr3142553867SilentNAH830H0.36
LUSCchr3142553869Missense_MutationNAH830N0.36
LUSCchr3142503418Missense_MutationnovelL1744F0.35
LUSCchr3142505212Missense_MutationnovelE1708G0.09
LUSCchr3142566123Frame_Shift_DelnovelI97*0.34
LUSCchr3142540943Missense_MutationNAG1181V0.12
LUSCchr3142540944Missense_MutationNAG1181C0.12
LUSCchr3142451720Intronnovel0.31
LUSCchr3142459370SilentNAT2402T0.31
LUSCchr31424493483'UTRnovel0.24
LUSCchr3142459375Missense_MutationnovelM2401V0.09
LUSCchr3142493212Missense_MutationnovelG2000C0.15
LUSCchr3142466362Missense_MutationNAP2287T0.26
LUSCchr3142450470Intronnovel0.12
LUSCchr3142496481Missense_MutationNAQ1926H0.18
LUSCchr3142505276Missense_MutationNAD1687H0.28
LUSCchr3142453126Splice_SitenovelX2587_splice0.31
MESOchr3142555991Missense_Mutationrs144835955R743G0.08
MESOchr3142560381Missense_MutationnovelI475L0.05
MESOchr3142568097Silentrs56297030Q39Q0.27
OVchr3142451122Intronnovel0.28
OVchr3142451483Intronnovel0.17
OVchr3142512271Missense_MutationnovelV1614A0.04
OVchr3142556106Missense_MutationNAK704N0.18
OVchr3142549547Missense_MutationnovelY1035N0.04
OVchr3142449430Silentnovel*2645*0.08
OVchr3142566217Missense_MutationnovelV66L0.2
OVchr3142560264Missense_MutationnovelC514S0.1
OVchr3142452141Intronnovel0.14
OVchr3142485194Missense_MutationNAN2056I0.14
OVchr3142550284Missense_MutationnovelH942Y0.37
OVchr3142519765Frame_Shift_DelnovelD1429Afs*260.04
OVchr3142461999Missense_MutationNAE2378V0.24
PAADchr3142562550SilentnovelD284D0.07
PAADchr3142449430Silentnovel*2645*0.18
PAADchr3142467994SilentnovelE2209E0.07
PAADchr3142493179Missense_MutationnovelE2011K0.19
PAADchr3142513553Missense_MutationnovelP1530Q0.17
PAADchr3142522776Silentrs770181975A1406A0.08
PAADchr3142524021Missense_MutationnovelE1375G0.03
PAADchr3142550205Missense_MutationnovelR968I0.15
PAADchr3142562937Missense_MutationnovelD155E0.15
PAADchr3142466385Missense_MutationnovelN2279T0.11
PAADchr3142524125Frame_Shift_DelnovelV1328Efs*350.12
PAADchr3142499714Nonsense_MutationnovelE1765*0.12
PCPGchr3142562596Missense_MutationnovelF269S0.35
PRADchr3142485175SilentNAG2062G0.07
PRADchr3142451064Intronnovel0.36
PRADchr3142553860Nonsense_MutationnovelE833*0.17
PRADchr3142512435Missense_MutationnovelD1559E0.31
PRADchr3142462043SilentnovelR2363R0.32
READchr3142452093Intronnovel0.44
READchr3142549606Missense_Mutationrs564283952R1015Q0.24
READchr3142512452Frame_Shift_DelnovelA1554Qfs*30.09
READchr3142493155Missense_MutationnovelN2019D0.66
READchr3142466432Missense_MutationnovelQ2263H0.05
READchr3142550143Missense_MutationNAR989C0.09
READchr3142451510Intronnovel0.56
READchr3142497094Missense_MutationNAR1886Q0.41
READchr3142499691Silentrs146463402T1772T0.36
READchr3142524007Missense_MutationNAD1380Y0.43
READchr3142547911Splice_SitenovelX1058_splice0.4
READchr3142549577Missense_MutationNAR1025C0.4
READchr3142556380Splice_Regionnovel0.43
READchr3142461954Missense_MutationnovelL2393R0.12
READchr3142550203Nonsense_MutationNAE969*0.46
READchr3142562758Missense_Mutationrs368507270R215H0.32
READchr3142449460Missense_MutationNAQ2635P0.41
SARCchr3142559433Missense_MutationnovelF517S0.33
SARCchr3142558777Splice_SitenovelX578_splice0.35
SARCchr3142465109SilentnovelS2343S0.19
SARCchr3142466353Missense_MutationnovelW2290R0.36
SKCMchr3142498745SilentNAL1804L0.48
SKCMchr3142555920SilentNAF766F0.56
SKCMchr3142465222Missense_MutationNAL2306F0.3
SKCMchr3142497116Missense_MutationNAD1879N0.37
SKCMchr3142469560Missense_Mutationrs751140070S2110F0.22
SKCMchr3142468059Missense_MutationnovelP2188S0.41
SKCMchr3142563105SilentNAF99F0.58
SKCMchr3142453217SilentnovelL2558L0.91
SKCMchr3142457719Missense_MutationNAR2514C0.3
SKCMchr3142461964SilentNAL2390L0.25
SKCMchr3142498655Missense_MutationNAL1834F0.28
SKCMchr3142451853Intronnovel0.85
SKCMchr3142560290Missense_MutationnovelV505A0.21
SKCMchr3142561280SilentNAL438L0.13
SKCMchr3142468001Missense_MutationNAS2207F0.22
SKCMchr3142549582Missense_MutationNAV1023A0.18
SKCMchr3142466523Missense_MutationNAS2233T0.4
SKCMchr3142453224SilentnovelK2555K0.37
SKCMchr3142562435Missense_MutationNAE323K0.1
SKCMchr3142459242Missense_MutationNAP2445L0.23
SKCMchr3142562392Missense_MutationNAL337H0.28
SKCMchr3142496403Silentrs778730760L1952L0.63
SKCMchr3142562491Missense_Mutationrs764261046P304L0.4
SKCMchr3142453199Missense_MutationNAE2564K0.08
SKCMchr3142561371Silentrs771710840I407I0.44
SKCMchr3142535133Missense_MutationNAD1298N0.24
SKCMchr3142536129Silentrs760913107A1266A0.32
SKCMchr3142515491Silentrs201300027T1469T0.52
SKCMchr3142515492Missense_Mutationrs747880325T1469I0.48
SKCMchr3142453208Missense_MutationnovelP2561S0.28
SKCMchr3142499637Nonsense_MutationNAY1790*0.34
SKCMchr3142512364Missense_MutationNAS1583F0.14
SKCMchr3142493257Missense_MutationNAP1985S0.23
SKCMchr3142561270Missense_MutationNAS441F0.18
SKCMchr3142562924Missense_Mutationrs770051146H160Y0.37
SKCMchr3142562925SilentnovelL159L0.36
SKCMchr3142453185SilentNAP2568P0.34
SKCMchr3142497073Missense_Mutationrs746443122S1893F0.45
SKCMchr3142485237Missense_MutationnovelL2042F0.39
SKCMchr3142485238SilentnovelY2041Y0.39
SKCMchr3142469518Missense_MutationnovelK2124R0.15
SKCMchr3142535127Missense_Mutationrs779170933R1300C0.67
SKCMchr3142496426Missense_MutationnovelL1945F0.08
SKCMchr3142550198Missense_MutationNAM970I0.43
SKCMchr3142550288SilentNAS940S0.46
SKCMchr3142553388Missense_MutationNAG882R0.36
SKCMchr3142559400Missense_MutationNAP528L0.25
SKCMchr3142450683Intronnovel0.32
SKCMchr3142462066Missense_Mutationrs755264430R2356C0.35
SKCMchr3142513509Nonsense_MutationnovelQ1545*0.42
SKCMchr3142508050Nonsense_MutationnovelQ1638*0.37
STADchr3142457619Missense_MutationNAR2547Q0.2
STADchr3142497163Missense_MutationnovelS1863N0.14
STADchr3142542713Frame_Shift_DelNAF1134Lfs*60.26
STADchr3142450781Intronnovel0.71
STADchr3142542713Frame_Shift_DelNAF1134Lfs*60.18
STADchr3142469500Missense_MutationNAT2130R0.39
STADchr3142498677SilentnovelV1826V0.11
STADchr3142498715Frame_Shift_DelNAR1814Efs*100.34
STADchr3142450503Intronnovel0.29
STADchr3142556550SilentNAV637V0.28
STADchr3142559439Missense_Mutationrs746970647R515H0.13
STADchr3142498715Frame_Shift_DelNAR1814Efs*100.22
STADchr3142468014Missense_MutationNAH2203N0.27
STADchr3142512434Missense_Mutationrs756354361D1560N0.32
STADchr3142563110Splice_SiteNAX98_splice0.33
STADchr3142451106Intronnovel0.19
STADchr3142468003Frame_Shift_DelnovelK2206Nfs*30.48
STADchr3142459231Missense_MutationnovelS2449P0.23
STADchr3142467960Missense_MutationNAK2221E0.08
STADchr3142524149SilentNAI1332I0.14
STADchr3142499715Silentrs745745176S1764S0.2
STADchr3142524078Frame_Shift_InsNAE1356Gfs*200.16
STADchr3142559357Frame_Shift_DelnovelV543Cfs*90.13
STADchr3142553395Silentrs150512706A879A0.24
STADchr3142450237Intronnovel0.33
STADchr3142512274Missense_MutationNAK1613T0.08
STADchr3142578648Splice_RegionNAG19G0.18
STADchr3142524171Missense_MutationNAS1325N0.1
STADchr3142566217Missense_MutationnovelV66L0.42
STADchr3142556117Missense_MutationnovelD701N0.14
STADchr3142459031Missense_MutationnovelH2477R0.19
STADchr3142549538Frame_Shift_DelnovelS1038Lfs*120.19
STADchr3142549560SilentNAI1030I0.1
STADchr3142549499Missense_Mutationrs367641692R1051C0.42
STADchr3142449580Missense_MutationnovelI2595S0.38
STADchr3142541010Missense_MutationNAM1159L0.33
STADchr3142469473Frame_Shift_DelnovelL2139*0.19
STADchr3142515428Missense_MutationNAW1490C0.28
STADchr3142556558Nonsense_MutationNAR635*0.28
STADchr3142547837Missense_Mutationrs146504354R1082H0.17
STADchr3142498715Frame_Shift_DelNAR1814Efs*100.23
STADchr3142547857SilentNAL1075L0.08
STADchr3142524078Frame_Shift_InsNAE1356Gfs*200.46
TGCTchr3142468010Missense_MutationnovelM2204T0.45
TGCTchr31425787625'UTRnovel0.27
THCAchr3142549613Missense_Mutationrs755521280L1013V0.32
THCAchr3142556103Frame_Shift_InsnovelK705Nfs*240.13
THCAchr3142547865Nonsense_MutationNAQ1073*0.3
THCAchr3142559374SilentNAL537L0.37
THYMchr3142550186Silentrs763559215T974T0.19
UCECchr3142451429Intronnovel0.24
UCECchr3142522759Missense_Mutationrs371292374R1412Q0.34
UCECchr3142556410Missense_MutationNAS684Y0.32
UCECchr3142452075Intronnovel0.12
UCECchr3142466403Missense_MutationnovelI2273S0.08
UCECchr3142550161Missense_Mutationrs537845660D983N0.35
UCECchr3142470098Missense_MutationnovelE2103K0.26
UCECchr3142493130Splice_SitenovelX2026_splice0.19
UCECchr3142449587Missense_MutationNAL2593I0.29
UCECchr3142451014Intronnovel0.36
UCECchr3142451141Intronnovel0.57
UCECchr3142459357Missense_Mutationrs746049210R2407C0.63
UCECchr3142497095Nonsense_Mutationrs141429029R1886*0.31
UCECchr3142449443Missense_MutationnovelT2641A0.36
UCECchr3142467986Missense_MutationnovelV2212A0.49
UCECchr3142485271Silentrs201988169A2030A0.26
UCECchr3142498714Frame_Shift_InsNAR1814Kfs*80.31
UCECchr3142522807Missense_MutationnovelL1396S0.36
UCECchr3142547729Missense_MutationnovelL1118P0.41
UCECchr3142561252Missense_MutationnovelQ447R0.33
UCECchr3142498715Frame_Shift_DelNAR1814Efs*100.37
UCECchr3142524007Missense_MutationNAD1380Y0.41
UCECchr3142562369Missense_MutationnovelA345S0.5
UCECchr3142512385Missense_MutationNAL1576R0.46
UCECchr3142550230Nonsense_MutationnovelR960*0.07
UCECchr3142562791Missense_MutationnovelF204C0.44
UCECchr3142449737Intronnovel0.42
UCECchr3142450770Intronnovel0.33
UCECchr3142503447Missense_MutationnovelH1735N0.21
UCECchr3142524035SilentnovelD1370D0.3
UCECchr3142578645Splice_SitenovelX20_splice0.4
UCECchr3142467935Missense_Mutationrs112373905P2229L0.33
UCECchr3142549577Missense_MutationNAR1025C0.49
UCECchr3142556490SilentnovelN657N0.37
UCECchr3142562565SilentnovelH279H0.52
UCECchr3142457668Missense_MutationnovelL2531I0.36
UCECchr3142562449Missense_MutationnovelL318S0.2
UCECchr3142515491Silentrs201300027T1469T0.05
UCECchr3142450893Intronnovel0.21
UCECchr3142451822Intronnovel0.2
UCECchr3142453150Missense_MutationNAT2580N0.2
UCECchr3142496458Missense_MutationNAA1934D0.2
UCECchr3142503414Missense_MutationNAL1746I0.24
UCECchr3142549606Missense_Mutationrs564283952R1015Q0.2
UCECchr3142559361Missense_MutationNAT541I0.16
UCECchr3142498715Frame_Shift_DelNAR1814Efs*100.26
UCECchr3142566194SilentNAQ73Q0.35
UCECchr3142459085Missense_Mutationrs754253403R2459H0.47
UCECchr3142465162Missense_Mutationrs766127973C2326R0.33
UCECchr3142450615Intronnovel0.04
UCECchr3142459294Missense_MutationNAL2428I0.08
UCECchr3142468000SilentNAS2207S0.24
UCECchr3142469421SilentnovelV2156V0.1
UCECchr3142498663Missense_MutationNAI1831S0.16
UCECchr3142522776Silentrs770181975A1406A0.1
UCECchr3142550140Missense_MutationnovelF990V0.12
UCECchr3142550142Missense_Mutationrs558627427R989H0.27
UCECchr3142562509Missense_MutationNAL298R0.13
UCECchr3142451389Intronnovel0.21
UCECchr3142453051Intronnovel0.21
UCECchr3142457615SilentnovelE2548E0.25
UCECchr3142535117Missense_MutationnovelA1303D0.15
UCECchr3142549576Missense_Mutationrs771309709R1025H0.19
UCECchr3142466427Missense_MutationnovelV2265G0.37
UCECchr3142450178Intronnovel0.72
UCECchr3142512419Missense_MutationnovelN1565D0.07
UCECchr3142522793Missense_MutationNAT1401A0.18
UCECchr3142550162Silentrs138061993F982F0.48
UCECchr3142549502Missense_MutationNAE1050Q0.53
UCECchr3142559338Missense_MutationNAS549G0.26
UCECchr3142462044Missense_Mutationrs142918229R2363Q0.44
UCECchr3142540938Nonsense_MutationnovelR1183*0.51
UCECchr3142549577Missense_MutationNAR1025C0.58
UCECchr3142562650Missense_MutationnovelF251C0.43
UCECchr3142452075Intronnovel0.4
UCECchr3142462040SilentnovelT2364T0.22
UCECchr3142507998Missense_MutationnovelV1655A0.35
UCECchr3142556106Missense_MutationnovelK704N0.52
UCECchr3142561285Missense_Mutationrs760248783S436L0.51
UCECchr3142562470Missense_MutationnovelR311K0.29
UCECchr3142562795Nonsense_MutationnovelE203*0.41
UCECchr3142562960Nonsense_MutationNAE148*0.47
UCECchr3142542712Frame_Shift_InsnovelN1135*0.26
UCECchr3142553377Silentrs756012253V885V0.33
UCECchr3142568115SilentnovelP33P0.29
UCECchr3142485272Missense_Mutationrs755650081A2030V0.23
UCECchr3142540949Missense_MutationnovelR1179I0.36
UCECchr3142459357Missense_Mutationrs746049210R2407C0.52
UCECchr3142553941Missense_MutationnovelL806I0.15
UCECchr3142508022Missense_Mutationrs758322712R1647H0.36
UCECchr3142457712Missense_MutationNAT2516I0.37
UCECchr31424493063'UTRnovel0.3
UCECchr3142449587Missense_MutationNAL2593I0.59
UCECchr3142451159Intronnovel0.38
UCECchr3142453230SilentnovelV2553V0.46
UCECchr3142536138Missense_MutationnovelK1263N0.43
UCECchr3142562920Missense_MutationnovelR161I0.59
UCECchr3142459284Missense_MutationNAR2431K0.5
UCECchr3142553336Missense_MutationNAK899T0.5
UCECchr3142459350Missense_MutationnovelC2409Y0.14
UCECchr3142451665Intronnovel0.36
UCECchr3142508028Missense_MutationNAS1645F0.39
UCECchr3142559439Missense_Mutationrs746970647R515H0.37
UCECchr31424493303'UTRnovel0.54
UCECchr3142451091Intronnovel0.75
UCECchr3142465200Missense_MutationnovelS2313Y0.11
UCECchr3142466502Missense_Mutationrs765461897S2240N0.22
UCECchr3142553948Missense_MutationnovelK803N0.45
UCECchr3142562800Missense_MutationnovelN201T0.33
UCECchr3142449504SilentnovelV2620V0.29
UCECchr3142549607Nonsense_MutationnovelR1015*0.22
UCECchr3142538599Missense_MutationnovelL1203R0.07
UCECchr3142451533Intronnovel0.34
UCECchr3142466531Splice_RegionnovelV2230V0.26
UCECchr3142469392Missense_MutationnovelK2166R0.23
UCECchr3142540937Missense_Mutationrs780802796R1183Q0.39
UCECchr3142560355Missense_Mutationrs200968047K483N0.18
UCECchr3142451015Intronnovel0.5
UCECchr3142550187Missense_Mutationrs771161299T974M0.34
UCECchr3142561294Missense_Mutationrs369434236R433H0.34
UCECchr3142562593Frame_Shift_DelnovelF270Sfs*80.35
UCECchr31424493913'UTRnovel0.32
UCECchr3142524007Missense_MutationNAD1380Y0.19
UCECchr3142549670Missense_MutationnovelT994A0.36
UCECchr3142459381Missense_MutationnovelV2399L0.29
UCECchr3142469412SilentnovelV2159V0.43
UCECchr3142485153Missense_MutationnovelL2070I0.44
UCECchr3142549569Missense_MutationnovelE1027D0.26
UCECchr3142513512Missense_MutationnovelD1544Y0.45
UCECchr3142542684Missense_MutationNAG1144D0.42
UCECchr3142519707SilentnovelE1448E0.48
UCECchr3142470097Missense_MutationNAE2103A0.32
UCECchr3142540944Missense_Mutationrs756014190G1181S0.26
UCECchr3142560427Missense_MutationnovelK459N0.08
UCECchr3142498715Frame_Shift_DelNAR1814Efs*100.43
UCECchr31424493063'UTRnovel0.33
UCECchr3142466516SilentNAS2235S0.26
UCECchr3142450729Intronnovel0.29
UCECchr3142535091Missense_MutationnovelY1312H0.32
UCECchr3142536192SilentnovelV1245V0.29
UCECchr3142536163Frame_Shift_DelnovelL1255Yfs*70.11
UCECchr3142449572Nonsense_MutationNAR2598*0.3
UCECchr3142562736Frame_Shift_DelNAF222Lfs*110.35
UCECchr3142485272Missense_Mutationrs755650081A2030V0.36
UCECchr3142550143Missense_MutationNAR989C0.07
UCECchr3142563060SilentnovelP114P0.5
UCECchr3142468003Frame_Shift_DelnovelK2206Nfs*30.33
UCECchr3142453066Intronnovel0.45
UCECchr3142470184Splice_SitenovelX2074_splice0.3
UCECchr3142515465Missense_MutationnovelI1478T0.39
UCECchr3142513635Nonsense_Mutationrs754602382R1503*0.36
UCECchr3142538607SilentNAV1200V0.32
UCECchr3142553327Missense_MutationNAS902Y0.09
UCECchr3142493138Frame_Shift_DelnovelK2024Nfs*50.48
UCECchr31424493233'UTRnovel0.38
UCECchr3142451960Intronnovel0.19
UCECchr3142542696Missense_MutationnovelS1140N0.28
UCECchr3142553724Missense_MutationnovelM850T0.5
UCECchr3142450295Intronnovel0.21
UCECchr3142450574Intronnovel0.44
UCECchr3142466416Missense_MutationnovelT2269A0.22
UCECchr3142493156SilentnovelS2018S0.2
UCECchr3142519697Missense_MutationnovelE1452K0.48
UCECchr3142553639Splice_SitenovelX878_splice0.16
UCECchr3142450488Intronnovel0.27
UCECchr3142453213Missense_MutationnovelH2559R0.36
UCECchr3142485165Missense_Mutationrs369309229R2066W0.43
UCECchr3142505304Splice_SiteNAX1678_splice0.41
UCECchr3142469395Missense_MutationNAA2165V0.26
UCECchr3142505164Missense_MutationNAR1724M0.15
UCECchr3142562361Nonsense_MutationNAC347*0.34
UCECchr3142562809Missense_MutationnovelS198I0.36
UCECchr3142538606Missense_MutationnovelR1201C0.38
UCECchr3142553856Missense_MutationnovelS834Y0.28
UCSchr3142449525Silentrs371176601P2613P0.5
UCSchr3142459357Missense_Mutationrs746049210R2407C0.37
UCSchr3142559349Missense_MutationnovelK545T0.3

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
KIRCDEL0.12690.11092

Survival Analysis
CancerP-value Q-value
SARC0.049

Kaplan-Meier Survival Analysis

ACC0.033

Kaplan-Meier Survival Analysis

SKCM0.0019

Kaplan-Meier Survival Analysis

PAAD0.0075

Kaplan-Meier Survival Analysis

CESC0.039

Kaplan-Meier Survival Analysis

READ0.049

Kaplan-Meier Survival Analysis

LAML0.0045

Kaplan-Meier Survival Analysis

KICH0.05

Kaplan-Meier Survival Analysis

LIHC0.00085

Kaplan-Meier Survival Analysis

LGG0.00013

Kaplan-Meier Survival Analysis

THCA0.019

Kaplan-Meier Survival Analysis

Drugs

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Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000175054 (Gene tree)
Gene ID
545
Gene Symbol
ATR
Alias
FRP1|SCKL|SCKL1|MEC1
Full Name
ATR serine/threonine kinase
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
129,592 bases
Position
chr3:142,449,235-142,578,826
Accession
882
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1. [provided by RefSeq, Aug 2017]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
24895251Molecular mechanisms and anti-cancer aspects of the medicinal phytochemicals rocaglamides (=flavaglines).Int J Cancer2015 Oct 15Li-Weber Mdoi: 10.1002/ijc.29013
19364474Cell cycle arrest triggered by conjugated eicosapentaenoic acid occurs through several mechanisms including G1 checkpoint activation by induced RPA and ATR expression.Biochim Biophys Acta2009 MayKumamoto-Yonezawa Ydoi: 10.1016/j.bbagen.2009.02.004
11137007Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint.Curr Biol2000 Dec 14-28Hekmat-Nejad M-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000515149ATR-208929-ENSP00000425897309 (aa)-D6RIG7
ENST00000511016ATR-205681--- (aa)--
ENST00000350721ATR-2018249XM_011512924ENSP000003437412644 (aa)XP_011511226Q13535
ENST00000507620ATR-204837--- (aa)--
ENST00000514393ATR-207552--- (aa)--
ENST00000504521ATR-202718-ENSP0000042255380 (aa)-H0Y8Y6
ENST00000515863ATR-210641--- (aa)--
ENST00000513291ATR-2065190-ENSP00000424355457 (aa)-H0Y9K2
ENST00000507148ATR-203724-ENSP00000426595100 (aa)-D6RFJ6
ENST00000515810ATR-209553-ENSP0000042187039 (aa)-H0Y8R8
Gene Model
Click here to download ENSG00000175054's gene model file
Pathways
Pathway IDPathway NameSource
hsa03460Fanconi anemia pathwayKEGG
hsa04110Cell cycleKEGG
hsa04115p53 signaling pathwayKEGG
hsa04218Cellular senescenceKEGG
hsa05165Human papillomavirus infectionKEGG
hsa05166Human T-cell leukemia virus 1 infectionKEGG
hsa05170Human immunodeficiency virus 1 infectionKEGG
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000175054rs22279303142558733TReticulocyte count27863252[0.022-0.037] unit increase0.02942073EFO_0007986
ENSG00000175054rs67802503142460655?Red blood cell count29403010[0.017-0.034] unit increase novel0.02525EFO_0004305
ENSG00000175054rs96830853142529656?Mean corpuscular volume29403010[0.051-0.068] unit decrease novel0.05979EFO_0004526
ENSG00000175054rs22279303142558733?Mean corpuscular hemoglobin29403010[0.045-0.062] unit decrease novel0.05332EFO_0004527
ENSG00000175054rs22279303142558733TReticulocyte fraction of red cells27863252[0.014-0.029] unit increase0.02152074EFO_0007986
ENSG00000175054rs76369093142541720GRed cell distribution width28957414[0.014-0.03] unit increase0.0218884EFO_0005192
ENSG00000175054rs76301153142491959?Red cell distribution width30595370EFO_0005192
ENSG00000175054rs67824003142576526?Red blood cell count30595370EFO_0004305
ENSG00000175054rs289102733142469495?Mean corpuscular hemoglobin30595370EFO_0004527
ENSG00000175054rs67824003142576526?Mean corpuscular hemoglobin30595370EFO_0004527
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000175054's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000077DNA damage checkpoint21873635.IBAProcess
GO:0000077DNA damage checkpoint14657349.IDAProcess
GO:0000723telomere maintenance21873635.IBAProcess
GO:0000784nuclear chromosome, telomeric region26586433.ICComponent
GO:0003677DNA binding-IEAFunction
GO:0004672protein kinase activity14657349.IDAFunction
GO:0004674protein serine/threonine kinase activity21873635.IBAFunction
GO:0004674protein serine/threonine kinase activity9733515.9925639.27723717.27723720.IDAFunction
GO:0004674protein serine/threonine kinase activity-TASFunction
GO:0005515protein binding14657349.17686975.18583959.19633697.19889979.20616048.20810650.20864032.20930849.27723717.27723720.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005694chromosome-ISSComponent
GO:0005794Golgi apparatus-IDAComponent
GO:0006260DNA replication-TASProcess
GO:0006281DNA repair8610130.TASProcess
GO:0006974cellular response to DNA damage stimulus27723717.27723720.IDAProcess
GO:0006974cellular response to DNA damage stimulus15538388.TASProcess
GO:0007275multicellular organism development9590286.TASProcess
GO:0008156negative regulation of DNA replication14657349.IMPProcess
GO:0016605PML body12814551.IDAComponent
GO:0018105peptidyl-serine phosphorylation9733515.IDAProcess
GO:0032212positive regulation of telomere maintenance via telomerase-ISSProcess
GO:0032405MutLalpha complex binding16713580.IDAFunction
GO:0032407MutSalpha complex binding16713580.IDAFunction
GO:0034644cellular response to UV9925639.IMPProcess
GO:0036297interstrand cross-link repair-TASProcess
GO:0042493response to drug-IEAProcess
GO:0043517positive regulation of DNA damage response, signal transduction by p53 class mediator9925639.IMPProcess
GO:0046777protein autophosphorylation9733515.IDAProcess
GO:0070198protein localization to chromosome, telomeric region21829167.IMPProcess
GO:0071480cellular response to gamma radiation9925639.IDAProcess
GO:0090399replicative senescence15149599.IMPProcess
GO:0097694establishment of RNA localization to telomere26586433.IMPProcess
GO:0097695establishment of protein-containing complex localization to telomere26586433.ICProcess
GO:1900034regulation of cellular response to heat-TASProcess
GO:1901796regulation of signal transduction by p53 class mediator-TASProcess
GO:1904884positive regulation of telomerase catalytic core complex assembly26586433.IMPProcess
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