EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23444224	Functional genetic screens identify genes essential for tumor cell survival in head and neck and lung cancer.	Clin Cancer Res	2013 Apr 15	Martens-de Kemp SR	doi: 10.1158/1078-0432.CCR-12-2539
26497677	Eribulin targets a ch-TOG-dependent directed migration of cancer cells.	Oncotarget	2015 Dec 8	Chanez B	doi: 10.18632/oncotarget.6147.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr11	46808117	Missense_Mutation	novel	E298Q	0.13
BLCA	chr11	46818465	Silent	novel	L32L	0.34
BLCA	chr11	46765215	Silent	NA	K1151K	0.25
BLCA	chr11	46744047	Silent	novel	E2025E	0.13
BLCA	chr11	46760723	Missense_Mutation	novel	S1428C	0.18
BLCA	chr11	46795711	Missense_Mutation	novel	K511N	0.41
BLCA	chr11	46780248	Missense_Mutation	novel	F793L	0.11
BLCA	chr11	46784609	Missense_Mutation	novel	S678L	0.11
BLCA	chr11	46744255	Missense_Mutation	NA	R1956Q	0.43
BLCA	chr11	46790539	Silent	rs756495835	G565G	0.66
BLCA	chr11	46750325	Missense_Mutation	NA	R1885G	0.2
BLCA	chr11	46760780	Missense_Mutation	novel	S1409F	0.69
BLCA	chr11	46762015	Silent	NA	F1402F	0.19
BLCA	chr11	46780238	Missense_Mutation	NA	E797K	0.2
BLCA	chr11	46780486	Splice_Site	NA	X750_splice	0.57
BLCA	chr11	46784632	Silent	novel	Q670Q	0.19
BLCA	chr11	46780211	Missense_Mutation	novel	D806H	0.15
BLCA	chr11	46762442	Intron	novel		0.28
BLCA	chr11	46788738	Silent	novel	C637C	0.75
BLCA	chr11	46770852	Missense_Mutation	novel	A1041V	0.3
BLCA	chr11	46762065	Missense_Mutation	novel	A1386T	0.22
BRCA	chr11	46777498	Missense_Mutation	NA	I935L	0.29
BRCA	chr11	46784637	In_Frame_Ins	novel	I668_A669insTQKNQILLWHLI	0.07
BRCA	chr11	46818441	Silent	NA	D40D	0.36
BRCA	chr11	46765198	Missense_Mutation	NA	S1157C	0.12
BRCA	chr11	46808129	Nonsense_Mutation	novel	Q294*	0.1
BRCA	chr11	46750581	Missense_Mutation	NA	D1831N	0.33
BRCA	chr11	46821190	Missense_Mutation	NA	Q14H	0.32
BRCA	chr11	46759378	Missense_Mutation	novel	D1487Y	0.19
BRCA	chr11	46777538	Silent	NA	L921L	0.15
BRCA	chr11	46753489	Missense_Mutation	NA	Q1626H	0.17
BRCA	chr11	46798140	Missense_Mutation	NA	E372D	0.28
BRCA	chr11	46788711	Missense_Mutation	NA	K646N	0.27
BRCA	chr11	46744545	Missense_Mutation	NA	P1913A	0.43
BRCA	chr11	46783357	Missense_Mutation	NA	M722I	0.31
BRCA	chr11	46751138	Missense_Mutation	NA	E1814K	0.25
BRCA	chr11	46753429	Silent	novel	L1646L	0.09
CESC	chr11	46811054	Missense_Mutation	rs770331121	I195V	0.54
CESC	chr11	46790560	Silent	novel	G558G	0.51
CESC	chr11	46759363	Missense_Mutation	NA	E1492Q	0.27
CESC	chr11	46762416	Intron	novel		0.33
CESC	chr11	46763004	Missense_Mutation	NA	S1288C	0.42
CESC	chr11	46763026	Missense_Mutation	NA	H1281Y	0.41
CESC	chr11	46753370	Missense_Mutation	novel	R1666H	0.35
CESC	chr11	46780472	Missense_Mutation	novel	A755S	0.33
CESC	chr11	46763540	Missense_Mutation	novel	D1210H	0.34
CESC	chr11	46755023	Silent	rs772497527	S1578S	0.28
CESC	chr11	46784604	Nonsense_Mutation	NA	Q680*	0.24
CESC	chr11	46811010	In_Frame_Del	novel	V209del	0.09
CESC	chr11	46755068	Splice_Site	novel	X1564_splice	0.43
CESC	chr11	46750407	Missense_Mutation	NA	K1857N	0.41
CHOL	chr11	46752708	Missense_Mutation	novel	A1687V	0.3
COAD	chr11	46753428	Missense_Mutation	NA	I1647V	0.29
COAD	chr11	46778199	Silent	rs745935099	P896P	0.44
COAD	chr11	46762088	Missense_Mutation	NA	R1378H	0.35
COAD	chr11	46778164	Missense_Mutation	rs199835668	R908Q	0.43
COAD	chr11	46816385	Missense_Mutation	novel	S91P	0.19
COAD	chr11	46743903	3'UTR	novel		0.32
COAD	chr11	46763119	Missense_Mutation	novel	T1250A	0.37
COAD	chr11	46770871	Nonsense_Mutation	novel	R1035*	0.29
COAD	chr11	46770858	Missense_Mutation	novel	Q1039R	0.12
COAD	chr11	46755022	Missense_Mutation	rs746453148	G1579S	0.14
COAD	chr11	46808083	Missense_Mutation	novel	N309T	0.38
COAD	chr11	46753373	Missense_Mutation	novel	I1665T	0.24
COAD	chr11	46762738	Missense_Mutation	novel	R1306C	0.41
COAD	chr11	46767609	Frame_Shift_Del	NA	*K1126Rfs25**	0.46
COAD	chr11	46811101	Missense_Mutation	novel	A179V	0.13
COAD	chr11	46816229	Missense_Mutation	novel	A143T	0.04
COAD	chr11	46801258	Missense_Mutation	novel	K342T	0.24
COAD	chr11	46762722	Missense_Mutation	rs766170007	A1311V	0.4
COAD	chr11	46780283	Missense_Mutation	novel	M782V	0.32
COAD	chr11	46809816	Missense_Mutation	rs762234437	R230Q	0.09
COAD	chr11	46795680	Missense_Mutation	NA	A522T	0.24
COAD	chr11	46796905	Silent	rs147577269	A458A	0.38
COAD	chr11	46763026	Missense_Mutation	NA	H1281N	0.36
COAD	chr11	46808136	Missense_Mutation	novel	K291N	0.07
COAD	chr11	46811051	Missense_Mutation	rs755030125	R196W	0.27
COAD	chr11	46744211	Frame_Shift_Ins	novel	*V1971Lfs42**	0.03
COAD	chr11	46795700	Nonsense_Mutation	novel	*K515Ifs4**	0.05
ESCA	chr11	46744167	Frame_Shift_Ins	novel	*R1986Afs16**	0.27
ESCA	chr11	46788741	Silent	novel	P636P	0.38
ESCA	chr11	46754887	Splice_Site	novel	X1623_splice	0.15
GBM	chr11	46770977	Silent	NA	L999L	0.27
GBM	chr11	46753487	Missense_Mutation	novel	I1627R	0.09
GBM	chr11	46809409	Nonsense_Mutation	novel	Y285*	0.2
GBM	chr11	46811046	Missense_Mutation	novel	D197E	0.15
GBM	chr11	46753440	Missense_Mutation	novel	M1643V	0.08
GBM	chr11	46762726	Missense_Mutation	NA	R1310C	0.05
GBM	chr11	46763541	Missense_Mutation	novel	Q1209H	0.18
GBM	chr11	46762131	Missense_Mutation	novel	P1364S	0.08
GBM	chr11	46796876	Missense_Mutation	novel	K468R	0.13
GBM	chr11	46751491	Frame_Shift_Ins	novel	*S1726Mfs3**	0.13
HNSC	chr11	46821267	Splice_Region	novel		0.33
HNSC	chr11	46816246	Missense_Mutation	novel	N137S	0.05
HNSC	chr11	46770168	Intron	novel		0.09
HNSC	chr11	46770170	Intron	novel		0.09
HNSC	chr11	46759362	Missense_Mutation	novel	E1492V	0.2
HNSC	chr11	46744062	Missense_Mutation	novel	L2020F	0.27
HNSC	chr11	46788758	Missense_Mutation	novel	D631N	0.37
HNSC	chr11	46801295	Missense_Mutation	novel	K330E	0.35
HNSC	chr11	46778545	Missense_Mutation	rs761653051	S830G	0.28
HNSC	chr11	46780314	Silent	novel	V771V	0.22
HNSC	chr11	46778465	Missense_Mutation	novel	E856D	0.3
HNSC	chr11	46762699	Missense_Mutation	novel	V1319F	0.15
HNSC	chr11	46750419	Silent	novel	L1853L	0.24
KIRC	chr11	46763591	Missense_Mutation	novel	I1193V	0.38
KIRC	chr11	46760649	Missense_Mutation	rs540835227	R1453C	0.19
KIRC	chr11	46765200	Missense_Mutation	novel	K1156N	0.21
KIRC	chr11	46763495	Missense_Mutation	novel	A1225T	0.12
KIRC	chr11	46744543	Silent	NA	P1913P	0.05
KIRP	chr11	46821232	5'UTR	novel		0.38
KIRP	chr11	46770119	Intron	novel		0.25
KIRP	chr11	46811114	Missense_Mutation	novel	S175P	0.33
KIRP	chr11	46777454	Silent	NA	V949V	0.4
KIRP	chr11	46778175	Silent	novel	A904A	0.22
LAML	chr11	46770887	Silent	novel	D1029D	0.12
LGG	chr11	46760784	Missense_Mutation	novel	L1408F	0.16
LGG	chr11	46808133	Frame_Shift_Del	NA	*K292Nfs12**	0.25
LGG	chr11	46751468	Missense_Mutation	novel	L1734M	0.37
LGG	chr11	46762728	Missense_Mutation	novel	V1309A	0.07
LGG	chr11	46770044	Missense_Mutation	novel	P1081S	0.06
LGG	chr11	46790509	Missense_Mutation	novel	K575N	0.35
LIHC	chr11	46750405	Missense_Mutation	novel	K1858R	0.07
LIHC	chr11	46795641	Missense_Mutation	novel	I535V	0.28
LIHC	chr11	46797842	Missense_Mutation	novel	K434M	0.19
LIHC	chr11	46783299	Missense_Mutation	NA	A742T	0.12
LIHC	chr11	46743936	3'UTR	novel		0.09
LIHC	chr11	46795623	Missense_Mutation	NA	G541R	0.1
LIHC	chr11	46744082	In_Frame_Ins	rs765113582	S2013dup	0.46
LUAD	chr11	46762737	Missense_Mutation	novel	R1306L	0.31
LUAD	chr11	46790503	Silent	NA	L577L	0.18
LUAD	chr11	46759414	Missense_Mutation	novel	E1475K	0.13
LUAD	chr11	46763514	Silent	novel	Q1218Q	0.15
LUAD	chr11	46744013	3'UTR	novel		0.16
LUAD	chr11	46753407	Missense_Mutation	novel	R1654W	0.18
LUAD	chr11	46753408	Silent	novel	S1653S	0.18
LUAD	chr11	46770890	Missense_Mutation	NA	E1028D	0.3
LUAD	chr11	46762002	Missense_Mutation	NA	N1407D	0.11
LUAD	chr11	46751189	Missense_Mutation	NA	M1797V	0.22
LUAD	chr11	46797969	Missense_Mutation	NA	T392A	0.16
LUAD	chr11	46818313	Missense_Mutation	NA	G83V	0.11
LUAD	chr11	46821219	Missense_Mutation	NA	S5C	0.11
LUAD	chr11	46765211	Missense_Mutation	NA	D1153H	0.04
LUAD	chr11	46762498	Intron	novel		0.21
LUAD	chr11	46809760	Missense_Mutation	NA	G249C	0.18
LUAD	chr11	46754899	Missense_Mutation	novel	N1620Y	0.22
LUAD	chr11	46753457	In_Frame_Del	novel	G1637del	0.1
LUAD	chr11	46760645	Missense_Mutation	novel	K1454M	0.08
LUAD	chr11	46777478	Frame_Shift_Ins	novel	*N941Kfs45**	0.29
LUSC	chr11	46809852	Missense_Mutation	rs751076163	W218L	0.49
LUSC	chr11	46818485	Missense_Mutation	rs777290124	S26G	0.27
LUSC	chr11	46762710	Missense_Mutation	rs370734058	R1315Q	0.38
LUSC	chr11	46751123	Missense_Mutation	rs773861293	R1819G	0.26
LUSC	chr11	46751166	Missense_Mutation	NA	Q1804H	0.21
LUSC	chr11	46780195	Missense_Mutation	novel	K811M	0.09
LUSC	chr11	46763563	Missense_Mutation	novel	S1202T	0.42
LUSC	chr11	46790153	Missense_Mutation	NA	L600F	0.19
LUSC	chr11	46776293	Missense_Mutation	NA	E985K	0.15
LUSC	chr11	46795637	Missense_Mutation	novel	S536Y	0.3
LUSC	chr11	46744201	Missense_Mutation	rs376393422	S1974F	0.26
LUSC	chr11	46750576	Silent	novel	F1832F	0.19
LUSC	chr11	46809757	Nonsense_Mutation	novel	G250*	0.25
LUSC	chr11	46811032	Missense_Mutation	NA	P202Q	0.18
LUSC	chr11	46770885	Missense_Mutation	novel	R1030L	0.24
LUSC	chr11	46784655	Missense_Mutation	novel	H663Y	0.23
LUSC	chr11	46743976	3'UTR	novel		0.31
LUSC	chr11	46744456	Silent	novel	L1942L	0.26
LUSC	chr11	46754968	Missense_Mutation	novel	N1597Y	0.3
LUSC	chr11	46776384	Splice_Site	novel	X955_splice	0.38
LUSC	chr11	46751355	Silent	NA	K1771K	0.39
LUSC	chr11	46763612	Frame_Shift_Del	novel	*T1186Lfs11**	0.18
LUSC	chr11	46770091	Missense_Mutation	novel	S1065C	0.22
LUSC	chr11	46751196	Silent	novel	L1794L	0.39
LUSC	chr11	46755028	Missense_Mutation	rs776008790	M1577V	0.3
LUSC	chr11	46760758	Silent	NA	L1416L	0.07
LUSC	chr11	46818454	Missense_Mutation	novel	Q36R	0.38
MESO	chr11	46778258	Silent	novel	R877R	0.29
OV	chr11	46760697	Missense_Mutation	NA	E1437K	0.1
OV	chr11	46751204	Missense_Mutation	novel	A1792T	0.04
OV	chr11	46796941	Splice_Site	NA	X447_splice	0.37
OV	chr11	46750555	Silent	novel	K1839K	0.1
OV	chr11	46760712	Missense_Mutation	novel	I1432L	0.1
OV	chr11	46811045	Missense_Mutation	NA	A198P	0.47
OV	chr11	46751425	Nonsense_Mutation	novel	*L1748delinsRVAGGPSLPDV**	0.06
OV	chr11	46770973	Frame_Shift_Del	novel	*W1001Afs3**	0.12
PAAD	chr11	46750325	Missense_Mutation	rs753596389	R1885W	0.18
PAAD	chr11	46778504	Silent	rs771488318	D843D	0.17
PAAD	chr11	46760649	Missense_Mutation	rs540835227	R1453C	0.1
PCPG	chr11	46770024	Silent	novel	P1087P	0.41
PCPG	chr11	46744054	Missense_Mutation	novel	R2023I	0.11
PRAD	chr11	46780260	Silent	NA	S789S	0.19
PRAD	chr11	46777446	Missense_Mutation	NA	D952G	0.13
PRAD	chr11	46751376	Silent	NA	L1764L	0.33
PRAD	chr11	46765197	Silent	rs144805720	S1157S	0.34
PRAD	chr11	46796866	Silent	rs138784594	G471G	0.44
READ	chr11	46809808	Missense_Mutation	NA	R233C	0.32
READ	chr11	46760648	Missense_Mutation	novel	R1453H	0.62
READ	chr11	46808126	Missense_Mutation	novel	E295K	0.18
READ	chr11	46809837	Missense_Mutation	novel	T223K	0.22
READ	chr11	46763062	Missense_Mutation	NA	K1269E	0.28
SARC	chr11	46752694	Missense_Mutation	novel	L1692F	0.29
SARC	chr11	46811044	Missense_Mutation	novel	A198D	0.05
SKCM	chr11	46759279	Missense_Mutation	novel	P1520S	0.26
SKCM	chr11	46776278	Missense_Mutation	NA	E990K	0.53
SKCM	chr11	46818421	Missense_Mutation	NA	S47F	0.35
SKCM	chr11	46778520	Missense_Mutation	NA	G838E	0.38
SKCM	chr11	46763499	Silent	novel	A1223A	0.31
SKCM	chr11	46778575	Missense_Mutation	rs267602899	P820S	0.24
SKCM	chr11	46811096	Nonsense_Mutation	novel	R181*	0.53
SKCM	chr11	46780224	Silent	NA	L801L	0.42
SKCM	chr11	46797908	Nonsense_Mutation	novel	*I412Kfs4**	0.07
SKCM	chr11	46743967	3'UTR	novel		0.32
SKCM	chr11	46751402	Missense_Mutation	NA	P1756S	0.17
SKCM	chr11	46818325	Missense_Mutation	NA	A79V	0.44
SKCM	chr11	46765175	Missense_Mutation	novel	P1165S	0.44
SKCM	chr11	46778205	Silent	NA	I894I	0.16
SKCM	chr11	46790518	Silent	NA	K572K	0.19
SKCM	chr11	46750549	Silent	NA	G1841G	0.35
SKCM	chr11	46744217	Missense_Mutation	NA	P1969S	0.25
SKCM	chr11	46762993	Missense_Mutation	NA	P1292S	0.35
SKCM	chr11	46750349	Nonsense_Mutation	NA	Q1877*	0.2
SKCM	chr11	46769965	Missense_Mutation	novel	S1107L	0.4
SKCM	chr11	46743993	3'UTR	novel		0.32
SKCM	chr11	46763122	Missense_Mutation	NA	L1249F	0.42
SKCM	chr11	46744230	Silent	NA	S1964S	0.12
SKCM	chr11	46750431	Splice_Region	NA	G1849G	0.16
SKCM	chr11	46776257	Missense_Mutation	NA	E997K	0.48
SKCM	chr11	46744484	Missense_Mutation	NA	S1933F	0.27
SKCM	chr11	46796844	Silent	novel	L479L	0.25
STAD	chr11	46809835	Missense_Mutation	NA	S224G	0.1
STAD	chr11	46790539	Silent	rs756495835	G565G	0.16
STAD	chr11	46783360	Silent	rs769721525	S721S	0.36
STAD	chr11	46798113	Silent	NA	L381L	0.36
STAD	chr11	46796905	Silent	rs147577269	A458A	0.56
STAD	chr11	46753324	Missense_Mutation	NA	Q1681H	0.23
STAD	chr11	46777479	Frame_Shift_Del	novel	*N941Ifs2**	0.4
STAD	chr11	46755065	Splice_Region	rs768394589	I1564I	0.3
STAD	chr11	46783342	Missense_Mutation	NA	K727N	0.38
STAD	chr11	46767594	Missense_Mutation	novel	G1131V	0.07
STAD	chr11	46788775	Splice_Site	novel	X626_splice	0.49
STAD	chr11	46821180	Missense_Mutation	NA	H18Y	0.33
STAD	chr11	46750546	Frame_Shift_Del	novel	F1837*	0.19
STAD	chr11	46796904	Missense_Mutation	rs377474304	A459T	0.29
STAD	chr11	46808076	Silent	NA	K311K	0.17
STAD	chr11	46778256	Missense_Mutation	NA	R877S	0.23
STAD	chr11	46770945	Missense_Mutation	NA	R1010H	0.16
STAD	chr11	46762695	Missense_Mutation	rs776238591	Y1320C	0.14
STAD	chr11	46759395	Missense_Mutation	NA	R1481H	0.09
STAD	chr11	46777495	Missense_Mutation	NA	K936Q	0.07
STAD	chr11	46797927	Missense_Mutation	novel	D406N	0.19
STAD	chr11	46808064	Silent	NA	G315G	0.31
STAD	chr11	46753415	Missense_Mutation	NA	L1651R	0.19
STAD	chr11	46744055	Frame_Shift_Del	NA	*R2023Dfs5**	0.2
STAD	chr11	46744179	Silent	NA	K1981K	0.23
STAD	chr11	46790564	Frame_Shift_Del	novel	*K557Rfs26**	0.19
STAD	chr11	46776253	Splice_Site	NA	X997_splice	0.08
TGCT	chr11	46797818	Missense_Mutation	novel	A442D	0.06
THCA	chr11	46808137	Nonsense_Mutation	novel	*A290_K291insMYVL**	0.05
UCEC	chr11	46750338	Silent	NA	V1880V	0.31
UCEC	chr11	46753410	Missense_Mutation	NA	S1653A	0.31
UCEC	chr11	46754948	Missense_Mutation	NA	E1603D	0.31
UCEC	chr11	46790116	Missense_Mutation	NA	N612T	0.33
UCEC	chr11	46798149	Missense_Mutation	novel	K369N	0.1
UCEC	chr11	46743641	3'UTR	novel		0.44
UCEC	chr11	46759395	Missense_Mutation	NA	R1481H	0.08
UCEC	chr11	46797869	Missense_Mutation	rs753718266	R425H	0.17
UCEC	chr11	46776358	Missense_Mutation	rs773132498	A963V	0.16
UCEC	chr11	46751232	Silent	rs369323220	I1782I	0.4
UCEC	chr11	46808087	Missense_Mutation	NA	K308Q	0.43
UCEC	chr11	46816251	Silent	NA	N135N	0.36
UCEC	chr11	46744073	Missense_Mutation	novel	I2017V	0.35
UCEC	chr11	46762726	Missense_Mutation	NA	R1310C	0.38
UCEC	chr11	46780461	Silent	NA	S758S	0.1
UCEC	chr11	46753357	Silent	novel	L1670L	0.37
UCEC	chr11	46760632	Missense_Mutation	novel	E1458D	0.4
UCEC	chr11	46765130	Splice_Site	novel	X1179_splice	0.4
UCEC	chr11	46811135	Missense_Mutation	novel	V168M	0.5
UCEC	chr11	46743577	3'UTR	novel		0.26
UCEC	chr11	46744209	Silent	novel	V1971V	0.29
UCEC	chr11	46788695	Nonsense_Mutation	novel	E652*	0.26
UCEC	chr11	46763506	Missense_Mutation	NA	N1221S	0.45
UCEC	chr11	46795718	Missense_Mutation	NA	A509V	0.29
UCEC	chr11	46760742	Missense_Mutation	NA	R1422W	0.15
UCEC	chr11	46798148	Frame_Shift_Ins	novel	*F370Ifs21**	0.08
UCEC	chr11	46818407	Missense_Mutation	NA	L52M	0.44
UCEC	chr11	46818444	Missense_Mutation	novel	K39N	0.16
UCEC	chr11	46776314	Silent	novel	L978L	0.15
UCEC	chr11	46780287	Silent	NA	G780G	0.41
UCEC	chr11	46783293	Missense_Mutation	novel	K744Q	0.12
UCEC	chr11	46811125	Missense_Mutation	novel	K171T	0.32
UCEC	chr11	46752653	Missense_Mutation	novel	F1705L	0.25
UCEC	chr11	46770946	Missense_Mutation	rs780302361	R1010C	0.39
UCEC	chr11	46778209	Missense_Mutation	novel	F893C	0.44
UCEC	chr11	46780467	Missense_Mutation	novel	F756L	0.14
UCEC	chr11	46763083	Missense_Mutation	novel	M1262V	0.43
UCEC	chr11	46798113	Silent	NA	L381L	0.33
UCEC	chr11	46762680	Missense_Mutation	novel	M1325T	0.39
UCEC	chr11	46780256	Nonsense_Mutation	novel	R791*	0.44
UCEC	chr11	46759353	Missense_Mutation	rs76048236	N1495S	0.1
UCEC	chr11	46751231	Missense_Mutation	rs781759452	D1783N	0.44
UCEC	chr11	46751471	Missense_Mutation	novel	L1733I	0.38
UCEC	chr11	46763587	Missense_Mutation	novel	E1194G	0.34
UCEC	chr11	46752653	Missense_Mutation	novel	F1705L	0.38
UCEC	chr11	46754979	Missense_Mutation	novel	R1593I	0.45
UCEC	chr11	46777453	Missense_Mutation	novel	L950I	0.41
UCEC	chr11	46798148	Missense_Mutation	novel	F370V	0.45
UCEC	chr11	46755007	Missense_Mutation	novel	F1584L	0.29
UCEC	chr11	46763125	Frame_Shift_Ins	novel	*W1248Pfs7**	0.09
UCEC	chr11	46763126	Silent	novel	K1247K	0.07
UCEC	chr11	46762074	Missense_Mutation	rs763418521	R1383C	0.2
UCEC	chr11	46776357	Silent	rs111240425	A963A	0.1
UCEC	chr11	46788695	Nonsense_Mutation	novel	E652*	0.15
UCEC	chr11	46750277	Missense_Mutation	novel	T1901A	0.34
UCEC	chr11	46784529	Missense_Mutation	novel	A705T	0.24
UCEC	chr11	46816320	Silent	novel	I112I	0.51
UCEC	chr11	46795665	Missense_Mutation	rs778951546	A527T	0.32
UCEC	chr11	46744540	Silent	NA	T1914T	0.06
UCEC	chr11	46750338	Silent	NA	V1880V	0.51
UCEC	chr11	46778545	Missense_Mutation	novel	S830R	0.28
UCEC	chr11	46762089	Missense_Mutation	novel	R1378C	0.49
UCEC	chr11	46762726	Missense_Mutation	NA	R1310C	0.27
UCEC	chr11	46809818	Silent	novel	T229T	0.38
UCEC	chr11	46811096	Nonsense_Mutation	novel	R181*	0.44
UCEC	chr11	46743555	3'UTR	novel		0.41
UCEC	chr11	46754933	Silent	novel	D1608D	0.39
UCEC	chr11	46809441	Nonsense_Mutation	novel	E275*	0.4
UCEC	chr11	46743811	3'UTR	novel		0.33
UCEC	chr11	46778142	Silent	rs147523907	I915I	0.06
UCEC	chr11	46811038	Missense_Mutation	NA	R200I	0.28
UCEC	chr11	46754889	Missense_Mutation	NA	S1623L	0.09
UCEC	chr11	46758967	Missense_Mutation	novel	V1549L	0.13
UCEC	chr11	46778503	Missense_Mutation	novel	G844W	0.3
UCEC	chr11	46743550	3'UTR	novel		0.24
UCEC	chr11	46784579	Missense_Mutation	novel	D688G	0.27
UCEC	chr11	46760730	Frame_Shift_Ins	novel	*R1426Lfs13**	0.08
UCEC	chr11	46760731	In_Frame_Ins	novel	K1425delinsNIW	0.06
UCEC	chr11	46762463	Intron	novel		0.34
UCEC	chr11	46795610	Frame_Shift_Del	NA	*K545Rfs38**	0.16
UCEC	chr11	46759395	Missense_Mutation	NA	R1481H	0.42
UCEC	chr11	46759039	Missense_Mutation	rs747586912	R1525W	0.05
UCEC	chr11	46744522	Silent	novel	S1920S	0.23
UCEC	chr11	46783275	Missense_Mutation	novel	G750R	0.23
UCEC	chr11	46744029	Silent	novel	R2031R	0.36
UCEC	chr11	46790563	Frame_Shift_Ins	novel	*K559Efs22**	0.31
UCEC	chr11	46751512	Frame_Shift_Ins	novel	*L1719Qfs15**	0.12
UCEC	chr11	46759417	Missense_Mutation	NA	P1474S	0.5
UCEC	chr11	46777457	Silent	NA	T948T	0.41
UCEC	chr11	46778142	Silent	rs147523907	I915I	0.36
UCEC	chr11	46750367	Missense_Mutation	NA	N1871H	0.24
UCEC	chr11	46754889	Missense_Mutation	NA	S1623L	0.27
UCEC	chr11	46798148	Frame_Shift_Ins	novel	*F370Ifs21**	0.04
UCEC	chr11	46762726	Missense_Mutation	NA	R1310C	0.19
UCEC	chr11	46744047	Missense_Mutation	novel	E2025D	0.43
UCEC	chr11	46751442	Silent	novel	V1742V	0.18
UCEC	chr11	46759039	Missense_Mutation	rs747586912	R1525W	0.19
UCEC	chr11	46762162	Silent	novel	E1353E	0.37
UCEC	chr11	46770175	Intron	novel		0.24
UCEC	chr11	46783363	Silent	novel	V720V	0.25
UCEC	chr11	46811051	Missense_Mutation	rs755030125	R196W	0.43
UCEC	chr11	46818337	Missense_Mutation	novel	Y75C	0.19
UCEC	chr11	46798119	Missense_Mutation	NA	Q379H	0.17
UCEC	chr11	46816286	Missense_Mutation	rs78408136	A124T	0.26
UCEC	chr11	46743811	3'UTR	novel		0.12
UCEC	chr11	46744109	Missense_Mutation	novel	S2005P	0.49
UCEC	chr11	46744031	Missense_Mutation	NA	R2031C	0.35
UCEC	chr11	46780202	Missense_Mutation	novel	F809L	0.08
UCEC	chr11	46790139	Silent	novel	C604C	0.37
UCEC	chr11	46795626	Missense_Mutation	novel	P540S	0.41
UCEC	chr11	46798113	Silent	NA	L381L	0.5
UCS	chr11	46777481	Missense_Mutation	novel	K940N	0.36

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ESCA	AMP	0.163	0.018342
GBM	DEL	0.1386	0.014054
PRAD	DEL	0.0589	0.0050014
TGCT	DEL	0.6133	0.21504
UCEC	AMP	0.0705	0.13129

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0029	Kaplan-Meier Survival Analysis
SARC	0.0012	Kaplan-Meier Survival Analysis
MESO	0.0001	Kaplan-Meier Survival Analysis
ACC	0.021	Kaplan-Meier Survival Analysis
HNSC	0.0075	Kaplan-Meier Survival Analysis
KIRP	0.0023	Kaplan-Meier Survival Analysis
PAAD	0.0069	Kaplan-Meier Survival Analysis
KICH	0.00029	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.037	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000175216 (Gene tree)
Gene ID: 9793
Gene Symbol: CKAP5
Alias: ch-TOG|KIAA0097|TOG|TOGp
Full Name: cytoskeleton associated protein 5
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 103,261 bases
Position: chr11:46,743,048-46,846,308
Accession: 28959
RBP type: non-canonical RBP
Summary: This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
28242011	Multivalent Molecules as Modulators of RNA Granule Size and Composition.	Biophys J	2017 Jul 25	Falkenberg CV	doi: 10.1016/j.bpj.2017.01.031
25547032	Identification of putative interactions between swine and human influenza A virus nucleoprotein and human host proteins.	Virol J	2014 Dec 30	Generous A	doi: 10.1186/s12985-014-0228-6.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000526496	CKAP5-205	582	-	ENSP00000436769	151 (aa)	-	E9PQH5
ENST00000525248	CKAP5-203	698	-	-	- (aa)	-	-
ENST00000525896	CKAP5-204	832	-	ENSP00000434523	203 (aa)	-	H0YDX5
ENST00000533413	CKAP5-212	3084	-	-	- (aa)	-	-
ENST00000526876	CKAP5-206	570	-	ENSP00000436052	190 (aa)	-	H0YEK7
ENST00000528593	CKAP5-209	366	-	-	- (aa)	-	-
ENST00000527333	CKAP5-208	498	-	ENSP00000431509	166 (aa)	-	H0YCF6
ENST00000532321	CKAP5-211	586	-	-	- (aa)	-	-
ENST00000529230	CKAP5-210	7121	-	ENSP00000432768	2032 (aa)	-	Q14008
ENST00000312055	CKAP5-201	6532	-	ENSP00000310227	1972 (aa)	-	Q14008
ENST00000354558	CKAP5-202	6428	-	ENSP00000346566	1972 (aa)	-	Q14008
ENST00000526943	CKAP5-207	563	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000175216's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000175216	Platelet Function Tests	9.5600000E-006	-
ENSG00000175216	Erythrocyte Count	3.0930000E-006	-
ENSG00000175216	Blood Pressure	2.3368560E-005	-
ENSG00000175216	Bone Density	7E-7	19079262

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000175216	rs1007738	11	46827809	A	Bone mineral density (hip)	19079262	[0.05-0.11] s.d. decrease	0.08	EFO_0003923
ENSG00000175216	rs61884327	11	46745340	T	Total body bone mineral density	29304378	unit decrease	0.0801	EFO_0003923
ENSG00000175216	rs10838622	11	46834985	T	Total body bone mineral density	29304378	unit increase	0.0491	EFO_0003923
ENSG00000175216	rs61884328	11	46761885	T	Total body bone mineral density (age over 60)	29304378	unit decrease	0.1063	EFO_0003923
ENSG00000175216	rs4534535	11	46767141	T	Pulse pressure	30578418	[0.12-0.23] mmHg decrease	0.1739	EFO_0005763
ENSG00000175216	rs11038990	11	46783211	?	Alzheimer's disease (late onset)	30820047	[1.05-1.13]	1.09	EFO_1001870

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000175216's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000175216	CKAP5	96	62.069	FBgn0027948	msps	89	46.196	Drosophila_melanogaster
ENSG00000175216	CKAP5	100	98.013	ENSMUSG00000040549	Ckap5	100	94.980	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000086	G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0000776	kinetochore	21873635.	IBA	Component
GO:0000776	kinetochore	25596274.	IDA	Component
GO:0000777	condensed chromosome kinetochore	-	IEA	Component
GO:0000922	spindle pole	21873635.	IBA	Component
GO:0000922	spindle pole	21646404.	IDA	Component
GO:0000930	gamma-tubulin complex	14718566.	IDA	Component
GO:0005515	protein binding	11903063.14603251.17474147.20360068.21297582.26496610.	IPI	Function
GO:0005730	nucleolus	-	IDA	Component
GO:0005813	centrosome	21873635.	IBA	Component
GO:0005813	centrosome	14718566.21399614.21646404.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0007019	microtubule depolymerization	26323690.	TAS	Process
GO:0007051	spindle organization	21873635.	IBA	Process
GO:0007051	spindle organization	14718566.	IMP	Process
GO:0007098	centrosome cycle	14718566.	IMP	Process
GO:0010389	regulation of G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0015630	microtubule cytoskeleton	15703215.	ISS	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity	21873635.	IBA	Process
GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity	14718566.	IMP	Process
GO:0032991	protein-containing complex	18468998.	IDA	Component
GO:0035371	microtubule plus-end	21873635.	IBA	Component
GO:0035371	microtubule plus-end	21646404.	IDA	Component
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0046785	microtubule polymerization	21873635.	IBA	Process
GO:0046785	microtubule polymerization	26323690.	TAS	Process
GO:0050658	RNA transport	15703215.	ISS	Process
GO:0051010	microtubule plus-end binding	21873635.	IBA	Function
GO:0051298	centrosome duplication	21873635.	IBA	Process
GO:0051301	cell division	-	IEA	Process
GO:0097711	ciliary basal body-plasma membrane docking	-	TAS	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.