EuRBPDB

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Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BRCA	chr5	176371847	Silent	NA	E229E	0.3
BRCA	chr5	176366490	Silent	rs779312966	S98S	0.16
BRCA	chr5	176372536	3'UTR	novel		0.17
BRCA	chr5	176368854	Missense_Mutation	NA	E145K	0.35	MMR_HSR1
CESC	chr5	176368893	Nonsense_Mutation	rs771015954	R158*	0.52	MMR_HSR1
CESC	chr5	176368899	Missense_Mutation	rs140105577	R160W	0.2	MMR_HSR1
CESC	chr5	176368804	Splice_Region	novel		0.59
CESC	chr5	176372684	3'UTR	novel		0.46
CESC	chr5	176371930	3'UTR	novel		0.3
COAD	chr5	176371775	Missense_Mutation	NA	Q205H	0.38
COAD	chr5	176371976	3'UTR	novel		0.45
COAD	chr5	176366479	Missense_Mutation	NA	R95C	0.31	MMR_HSR1
ESCA	chr5	176368899	Missense_Mutation	rs140105577	R160W	0.18	MMR_HSR1
ESCA	chr5	176368979	Missense_Mutation	novel	K186N	0.19	MMR_HSR1
GBM	chr5	176368816	Missense_Mutation	novel	S132T	0.09	MMR_HSR1
LIHC	chr5	176371908	3'UTR	novel		0.13
LIHC	chr5	176371736	Silent	novel	A192A	0.05
LUAD	chr5	176366482	Missense_Mutation	NA	V96L	0.43	MMR_HSR1
LUAD	chr5	176367965	Intron	novel		0.17
LUSC	chr5	176371779	Missense_Mutation	novel	I207V	0.14
OV	chr5	176371808	Missense_Mutation	NA	L216F	0.81
OV	chr5	176371879	Missense_Mutation	novel	L240W	0.74
SARC	chr5	176369089	Intron	novel		0.32
SARC	chr5	176371719	Splice_Region	novel		0.38
SKCM	chr5	176366519	Missense_Mutation	NA	P108L	0.19	MMR_HSR1
SKCM	chr5	176366394	Silent	NA	E66E	0.7
SKCM	chr5	176368964	Silent	NA	V181V	0.51
STAD	chr5	176371836	Missense_Mutation	novel	T226A	0.15
STAD	chr5	176366480	Missense_Mutation	novel	R95H	0.28	MMR_HSR1
STAD	chr5	176366502	Silent	NA	P102P	0.19
STAD	chr5	176371758	Missense_Mutation	rs769324573	R200W	0.29
STAD	chr5	176368827	Missense_Mutation	novel	R136C	0.26	MMR_HSR1
UCEC	chr5	176366397	Silent	NA	D67D	0.4
UCEC	chr5	176371781	Silent	novel	I207I	0.05
UCEC	chr5	176371730	Silent	rs752531389	S190S	0.2
UCEC	chr5	176366457	Silent	rs765036288	G87G	0.18
UCEC	chr5	176368899	Missense_Mutation	rs140105577	R160W	0.24	MMR_HSR1
UCEC	chr5	176368918	Missense_Mutation	novel	Q166R	0.45	MMR_HSR1
UCEC	chr5	176366501	Missense_Mutation	novel	P102L	0.25	MMR_HSR1
UCEC	chr5	176372687	3'UTR	novel		0.5
UCEC	chr5	176372724	3'UTR	novel		0.36
UCEC	chr5	176369004	Intron	novel		0.39
UCEC	chr5	176366471	Missense_Mutation	NA	T92M	0.52	MMR_HSR1
UCEC	chr5	176372823	3'UTR	novel		0.38
UCEC	chr5	176368962	Missense_Mutation	rs766529336	V181I	0.38	MMR_HSR1
UCEC	chr5	176369124	Intron	novel		0.14
UCEC	chr5	176367981	Intron	novel		0.33
UCEC	chr5	176369055	Intron	novel		0.48
UCEC	chr5	176366409	Silent	NA	A71A	0.35
UCEC	chr5	176371780	Missense_Mutation	novel	I207S	0.71
UCEC	chr5	176371757	Silent	NA	Q199Q	0.36
UCEC	chr5	176368951	Missense_Mutation	novel	D177G	0.37	MMR_HSR1
UCEC	chr5	176369077	Intron	novel		0.51

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRC	AMP	0.5909	2.1944e-60
KIRP	AMP	0.1111	0.069756
KIRP	DEL	0.0382	0.11554
LGG	DEL	0.0858	1.86e-07
LUAD	AMP	0.1725	0.24967
LUSC	DEL	0.5988	0.002071
MESO	DEL	0.1149	0.20184
PRAD	AMP	0.0305	0.16448
SKCM	AMP	0.1144	0.23703
THCA	DEL	0	0.23456

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00011	Kaplan-Meier Survival Analysis
STAD	0.047	Kaplan-Meier Survival Analysis
SARC	0.005	Kaplan-Meier Survival Analysis
MESO	0.00012	Kaplan-Meier Survival Analysis
ACC	0.049	Kaplan-Meier Survival Analysis
KIRP	0.03	Kaplan-Meier Survival Analysis
COAD	0.031	Kaplan-Meier Survival Analysis
BLCA	0.033	Kaplan-Meier Survival Analysis
UCEC	0.0051	Kaplan-Meier Survival Analysis
LIHC	0.0078	Kaplan-Meier Survival Analysis
CHOL	0.04	Kaplan-Meier Survival Analysis
OV	0.0023	Kaplan-Meier Survival Analysis

Description

RBDs

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000175414 (Gene tree)
Gene ID: 285598
Gene Symbol: ARL10
Alias: ARL10A
Full Name: ADP ribosylation factor like GTPase 10
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 49,996 bases
Position: chr5:176,365,468-176,415,463
Accession: 22042
RBP type: canonical RBP
Summary: ARL10 (ADP Ribosylation Factor Like GTPase 10) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTP binding. An important paralog of this gene is TRIM23.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000308496	MMR_HSR1	PF01926.23	7.8e-05	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000310389	ARL10-201	10845	XM_011534531	ENSP00000308496	244 (aa)	XP_011532833	Q8N8L6
ENST00000507151	ARL10-203	365	-	-	- (aa)	-	-
ENST00000503175	ARL10-202	380	-	ENSP00000424831	79 (aa)	-	H0Y9R6
ENST00000514533	ARL10-204	258	-	ENSP00000421449	48 (aa)	-	H0Y8L6

Gene Model

Click here to download ENSG00000175414's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000175414's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000175414	ARL10	99	92.562	ENSAMEG00000006984	ARL10	99	92.562	Ailuropoda_melanoleuca
ENSG00000175414	ARL10	92	65.909	ENSACAG00000006350	ARL10	91	45.259	Anolis_carolinensis
ENSG00000175414	ARL10	100	96.311	ENSANAG00000029366	ARL10	100	96.311	Aotus_nancymaae
ENSG00000175414	ARL10	94	93.333	ENSBTAG00000025345	ARL10	92	87.317	Bos_taurus
ENSG00000175414	ARL10	100	96.311	ENSCJAG00000012332	ARL10	100	96.311	Callithrix_jacchus
ENSG00000175414	ARL10	92	95.455	ENSCAFG00000016697	ARL10	87	94.048	Canis_familiaris
ENSG00000175414	ARL10	100	94.262	ENSCAFG00020011500	ARL10	100	94.262	Canis_lupus_dingo
ENSG00000175414	ARL10	69	90.909	ENSTSYG00000036186	ARL10	84	80.952	Carlito_syrichta
ENSG00000175414	ARL10	100	93.033	ENSCPOG00000001642	ARL10	100	93.033	Cavia_porcellus
ENSG00000175414	ARL10	100	95.902	ENSCCAG00000032554	ARL10	100	95.902	Cebus_capucinus
ENSG00000175414	ARL10	100	97.951	ENSCATG00000012151	ARL10	100	97.951	Cercocebus_atys
ENSG00000175414	ARL10	100	90.984	ENSCLAG00000015048	ARL10	100	90.984	Chinchilla_lanigera
ENSG00000175414	ARL10	100	98.770	ENSCSAG00000009428	ARL10	100	98.770	Chlorocebus_sabaeus
ENSG00000175414	ARL10	92	97.727	ENSCANG00000036364	ARL10	100	98.160	Colobus_angolensis_palliatus
ENSG00000175414	ARL10	100	88.525	ENSCGRG00001022470	-	100	86.475	Cricetulus_griseus_chok1gshd
ENSG00000175414	ARL10	92	79.545	ENSCGRG00000011571	Arl10	89	88.095	Cricetulus_griseus_crigri
ENSG00000175414	ARL10	100	92.213	ENSDNOG00000043008	-	100	92.213	Dasypus_novemcinctus
ENSG00000175414	ARL10	100	93.852	ENSEASG00005011981	ARL10	100	93.852	Equus_asinus_asinus
ENSG00000175414	ARL10	90	60.465	ENSELUG00000011113	-	90	42.081	Esox_lucius
ENSG00000175414	ARL10	100	93.852	ENSFCAG00000042295	ARL10	100	93.852	Felis_catus
ENSG00000175414	ARL10	92	88.636	ENSFDAG00000016410	ARL10	84	91.071	Fukomys_damarensis
ENSG00000175414	ARL10	83	65.000	ENSFHEG00000016443	ARL10	88	39.367	Fundulus_heteroclitus
ENSG00000175414	ARL10	90	62.791	ENSGMOG00000004201	ARL10	98	50.370	Gadus_morhua
ENSG00000175414	ARL10	92	68.182	ENSGALG00000003360	ARL10	99	47.368	Gallus_gallus
ENSG00000175414	ARL10	94	71.111	ENSGAGG00000013245	ARL10	92	54.971	Gopherus_agassizii
ENSG00000175414	ARL10	100	99.590	ENSGGOG00000005219	-	100	99.590	Gorilla_gorilla
ENSG00000175414	ARL10	97	88.186	ENSHGLG00000005509	ARL10	100	88.115	Heterocephalus_glaber_female
ENSG00000175414	ARL10	97	88.186	ENSHGLG00100008434	ARL10	100	88.115	Heterocephalus_glaber_male
ENSG00000175414	ARL10	100	91.020	ENSSTOG00000004854	ARL10	100	91.429	Ictidomys_tridecemlineatus
ENSG00000175414	ARL10	98	87.234	ENSJJAG00000015006	Arl10	100	79.508	Jaculus_jaculus
ENSG00000175414	ARL10	92	61.364	ENSLACG00000014817	ARL10	96	43.277	Latimeria_chalumnae
ENSG00000175414	ARL10	100	88.115	ENSLAFG00000017880	ARL10	100	88.115	Loxodonta_africana
ENSG00000175414	ARL10	100	98.361	ENSMFAG00000033979	ARL10	100	98.361	Macaca_fascicularis
ENSG00000175414	ARL10	100	98.361	ENSMMUG00000019715	ARL10	100	98.361	Macaca_mulatta
ENSG00000175414	ARL10	100	97.541	ENSMNEG00000037218	ARL10	100	97.541	Macaca_nemestrina
ENSG00000175414	ARL10	92	97.727	ENSMLEG00000029969	ARL10	91	96.739	Mandrillus_leucophaeus
ENSG00000175414	ARL10	100	86.475	ENSMAUG00000016615	Arl10	100	86.475	Mesocricetus_auratus
ENSG00000175414	ARL10	100	87.295	ENSMOCG00000017185	Arl10	100	86.475	Microtus_ochrogaster
ENSG00000175414	ARL10	94	84.444	MGP_CAROLIEiJ_G0018537	Arl10	92	86.096	Mus_caroli
ENSG00000175414	ARL10	94	84.444	ENSMUSG00000025870	Arl10	92	87.166	Mus_musculus
ENSG00000175414	ARL10	94	84.444	MGP_PahariEiJ_G0019602	Arl10	92	85.561	Mus_pahari
ENSG00000175414	ARL10	94	84.444	MGP_SPRETEiJ_G0019417	Arl10	92	87.166	Mus_spretus
ENSG00000175414	ARL10	100	93.852	ENSMPUG00000012576	ARL10	100	93.852	Mustela_putorius_furo
ENSG00000175414	ARL10	94	91.111	ENSNGAG00000005101	Arl10	81	91.979	Nannospalax_galili
ENSG00000175414	ARL10	98	93.617	ENSNLEG00000012489	-	93	98.315	Nomascus_leucogenys
ENSG00000175414	ARL10	100	87.295	ENSODEG00000009842	ARL10	100	87.295	Octodon_degus
ENSG00000175414	ARL10	92	90.909	ENSOCUG00000023334	-	87	91.071	Oryctolagus_cuniculus
ENSG00000175414	ARL10	96	63.043	ENSORLG00000018307	-	89	44.118	Oryzias_latipes
ENSG00000175414	ARL10	90	65.116	ENSOMEG00000023727	ARL10	86	39.574	Oryzias_melastigma
ENSG00000175414	ARL10	100	90.574	ENSOGAG00000000826	ARL10	100	90.574	Otolemur_garnettii
ENSG00000175414	ARL10	92	95.455	ENSOARG00000002098	ARL10	100	79.508	Ovis_aries
ENSG00000175414	ARL10	92	100.000	ENSPPAG00000039208	-	98	96.842	Pan_paniscus
ENSG00000175414	ARL10	100	93.852	ENSPPRG00000017068	ARL10	100	93.852	Panthera_pardus
ENSG00000175414	ARL10	92	95.455	ENSPTIG00000011683	ARL10	69	94.048	Panthera_tigris_altaica
ENSG00000175414	ARL10	100	99.590	ENSPTRG00000046949	ARL10	100	99.590	Pan_troglodytes
ENSG00000175414	ARL10	100	97.541	ENSPANG00000011859	ARL10	100	97.541	Papio_anubis
ENSG00000175414	ARL10	92	70.455	ENSPSIG00000013641	ARL10	97	55.090	Pelodiscus_sinensis
ENSG00000175414	ARL10	92	93.182	ENSPCAG00000004681	ARL10	100	81.557	Procavia_capensis
ENSG00000175414	ARL10	100	92.623	ENSPCOG00000017730	ARL10	100	92.623	Propithecus_coquereli
ENSG00000175414	ARL10	100	91.803	ENSPVAG00000007499	ARL10	100	91.803	Pteropus_vampyrus
ENSG00000175414	ARL10	92	88.636	ENSRNOG00000045948	Arl10	87	88.690	Rattus_norvegicus
ENSG00000175414	ARL10	100	98.770	ENSRBIG00000030159	ARL10	100	98.770	Rhinopithecus_bieti
ENSG00000175414	ARL10	100	98.770	ENSRROG00000033178	ARL10	100	98.770	Rhinopithecus_roxellana
ENSG00000175414	ARL10	71	84.483	ENSSBOG00000031819	ARL10	88	84.524	Saimiri_boliviensis_boliviensis
ENSG00000175414	ARL10	92	86.364	ENSSHAG00000000707	ARL10	99	62.753	Sarcophilus_harrisii
ENSG00000175414	ARL10	100	93.033	ENSSSCG00000029985	ARL10	100	93.033	Sus_scrofa
ENSG00000175414	ARL10	100	89.754	ENSTTRG00000005396	ARL10	100	89.754	Tursiops_truncatus
ENSG00000175414	ARL10	100	93.443	ENSUAMG00000005136	ARL10	100	93.443	Ursus_americanus
ENSG00000175414	ARL10	94	93.333	ENSUMAG00000024507	ARL10	90	74.684	Ursus_maritimus
ENSG00000175414	ARL10	100	94.262	ENSVVUG00000001760	ARL10	100	94.262	Vulpes_vulpes
ENSG00000175414	ARL10	85	65.854	ENSXETG00000022337	arl10	80	42.466	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005525	GTP binding	-	IEA	Function

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.