EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr3	123956638	Intron	novel		0.83
ACC	chr3	123931423	Silent	novel	V517V	0.18
ACC	chr3	123914842	Silent	rs745716061	A892A	0.29
BLCA	chr3	123931220	Missense_Mutation	novel	L561V	0.28
BLCA	chr3	123915336	Missense_Mutation	novel	E728Q	0.09
BLCA	chr3	123915243	Nonsense_Mutation	NA	Q759*	0.18
BLCA	chr3	123947273	Missense_Mutation	novel	T251R	0.37
BLCA	chr3	123915317	Missense_Mutation	rs762784036	D734G	0.18
BLCA	chr3	123949067	Missense_Mutation	novel	D147N	0.56
BLCA	chr3	123931190	In_Frame_Ins	novel	K570_L571insKTS	0.12
BRCA	chr3	123931219	Missense_Mutation	NA	L561P	0.34
BRCA	chr3	123933749	Silent	rs375071266	L457L	0.05
BRCA	chr3	123933726	Missense_Mutation	novel	R465T	0.04
BRCA	chr3	123948717	Missense_Mutation	NA	P227S	0.35
BRCA	chr3	123915473	Missense_Mutation	rs372947520	T682S	0.36
BRCA	chr3	123944944	Missense_Mutation	NA	I423M	0.19
BRCA	chr3	123956700	Intron	novel		0.5
BRCA	chr3	123956819	Intron	novel		0.16
BRCA	chr3	123947219	Missense_Mutation	NA	G269A	0.26
BRCA	chr3	123915389	Missense_Mutation	NA	S710F	0.4
BRCA	chr3	123961285	Silent	NA	R11R	0.17
BRCA	chr3	123956457	Intron	novel		0.2
BRCA	chr3	123956074	Silent	NA	L115L	0.19
BRCA	chr3	123961202	Missense_Mutation	novel	S39W	0.17
BRCA	chr3	123956138	Intron	novel		0.24
BRCA	chr3	123956886	Intron	novel		0.17
BRCA	chr3	123956742	Frame_Shift_Del	NA	*A77Rfs4**	0.26
CESC	chr3	123915672	Missense_Mutation	novel	D616Y	0.38
CESC	chr3	123949061	Missense_Mutation	NA	E149K	0.16
CESC	chr3	123956371	Missense_Mutation	NA	S96C	0.36
CESC	chr3	123915618	Missense_Mutation	NA	H634Y	0.2
CESC	chr3	123944923	Silent	novel	S430S	0.39
CESC	chr3	123946853	Missense_Mutation	novel	R391K	0.39
CESC	chr3	123931392	Frame_Shift_Ins	novel	*F528Ifs2**	0.31
CESC	chr3	123956557	Intron	rs181374761		0.25
CESC	chr3	123944934	Missense_Mutation	novel	P427S	0.17
CESC	chr3	123946891	Silent	rs201587585	Q378Q	0.16
CESC	chr3	123955945	Intron	NA		0.15
COAD	chr3	123948751	Silent	NA	L215L	0.32
COAD	chr3	123931139	Missense_Mutation	rs754428441	R588C	0.22
COAD	chr3	123956327	Intron	novel		0.11
COAD	chr3	123915067	Missense_Mutation	novel	K817N	0.23
COAD	chr3	123915553	Silent	novel	K655K	0.33
COAD	chr3	123947238	Missense_Mutation	rs759221863	S263A	0.28
COAD	chr3	123957006	Intron	novel		0.31
COAD	chr3	123931126	Missense_Mutation	novel	V592G	0.24
COAD	chr3	123956778	Silent	novel	R64R	0.08
COAD	chr3	123946937	Missense_Mutation	NA	D363V	0.13
COAD	chr3	123956723	Intron	rs371420050		0.16
COAD	chr3	123956033	Intron	NA		0.22
COAD	chr3	123956879	Intron	novel		0.38
COAD	chr3	123914785	Missense_Mutation	NA	E911D	0.14
COAD	chr3	123946827	Missense_Mutation	novel	L400F	0.14
COAD	chr3	123955887	Intron	novel		0.15
COAD	chr3	123955889	Intron	novel		0.16
COAD	chr3	123946880	Frame_Shift_Del	NA	*N382Mfs2**	0.33
COAD	chr3	123931112	Nonsense_Mutation	rs750323203	E597*	0.35
COAD	chr3	123915354	Nonsense_Mutation	NA	E722*	0.38
COAD	chr3	123956464	Intron	novel		0.35
COAD	chr3	123931106	Missense_Mutation	NA	T599A	0.24
COAD	chr3	123915674	Frame_Shift_Ins	novel	*V615Afs13**	0.05
COAD	chr3	123915675	Nonsense_Mutation	novel	*S614_V615insFLII*	0.03
COAD	chr3	123931228	Frame_Shift_Ins	novel	*E558Vfs7**	0.04
COAD	chr3	123931229	Frame_Shift_Ins	novel	*E558Rfs13**	0.03
ESCA	chr3	123914137	3'UTR	novel		0.28
ESCA	chr3	123949053	Missense_Mutation	novel	N151K	0.09
ESCA	chr3	123956205	Intron	novel		0.27
ESCA	chr3	123915665	Missense_Mutation	novel	A618V	0.38
ESCA	chr3	123915586	Silent	novel	P644P	0.06
ESCA	chr3	123914218	3'UTR	novel		0.34
ESCA	chr3	123931178	Missense_Mutation	novel	E575K	0.36
ESCA	chr3	123913979	3'UTR	novel		0.44
ESCA	chr3	123914244	3'UTR	novel		0.42
ESCA	chr3	123914060	3'UTR	novel		0.18
GBM	chr3	123914785	Missense_Mutation	NA	E911D	0.5
HNSC	chr3	123946914	Missense_Mutation	NA	T371A	0.22
HNSC	chr3	123946898	Missense_Mutation	novel	D376V	0.15
HNSC	chr3	123914962	Silent	novel	V852V	0.17
HNSC	chr3	123933716	Missense_Mutation	novel	Q468H	0.16
HNSC	chr3	123915000	Missense_Mutation	novel	H840N	0.16
HNSC	chr3	123915143	Missense_Mutation	rs147561384	S792C	0.5
HNSC	chr3	123915686	Missense_Mutation	NA	S611F	0.28
KIRC	chr3	123956512	Intron	novel		0.56
KIRC	chr3	123915696	Missense_Mutation	NA	K608E	0.06
KIRC	chr3	123956266	Intron	novel		0.1
KIRP	chr3	123944900	Missense_Mutation	novel	E438A	0.27
KIRP	chr3	123956337	Intron	novel		0.43
LAML	chr3	123947188	Silent	novel	I279I	0.24
LAML	chr3	123946958	Missense_Mutation	rs765575817	E356G	0.04
LIHC	chr3	123946897	Missense_Mutation	NA	D376E	0.16
LIHC	chr3	123949062	Silent	novel	L148L	0.03
LIHC	chr3	123956053	Silent	novel	E122E	0.1
LIHC	chr3	123931161	Missense_Mutation	NA	I580M	0.37
LIHC	chr3	123915435	Frame_Shift_Ins	novel	S695*	0.27
LUAD	chr3	123914926	Silent	NA	T864T	0.13
LUAD	chr3	123915575	Missense_Mutation	novel	S648Y	0.32
LUAD	chr3	123944870	Missense_Mutation	novel	S448T	0.16
LUAD	chr3	123946917	Missense_Mutation	NA	D370Y	0.29
LUAD	chr3	123947192	Missense_Mutation	novel	D278V	0.23
LUAD	chr3	123914941	Silent	novel	D859D	0.11
LUAD	chr3	123915672	Missense_Mutation	novel	D616Y	0.13
LUAD	chr3	123915378	Nonsense_Mutation	novel	K714*	0.2
LUAD	chr3	123914966	Missense_Mutation	NA	Q851L	0.22
LUSC	chr3	123915672	Missense_Mutation	novel	D616N	0.35
LUSC	chr3	123931155	Silent	NA	G582G	0.22
LUSC	chr3	123915324	Missense_Mutation	NA	N732D	0.15
LUSC	chr3	123915154	Silent	NA	V788V	0.22
LUSC	chr3	123949060	Missense_Mutation	NA	E149G	0.14
LUSC	chr3	123944897	Missense_Mutation	NA	I439K	0.41
LUSC	chr3	123915211	Silent	novel	L769L	0.21
LUSC	chr3	123915254	Missense_Mutation	novel	R755I	0.2
OV	chr3	123961319	5'UTR	novel		0.22
PAAD	chr3	123947089	Silent	novel	T312T	0.16
READ	chr3	123956490	Intron	novel		0.24
READ	chr3	123931112	Nonsense_Mutation	rs750323203	E597*	0.33
READ	chr3	123931319	Missense_Mutation	NA	R552I	0.42
READ	chr3	123955892	Intron	novel		0.2
SARC	chr3	123961356	5'UTR	novel		0.12
SKCM	chr3	123946986	Missense_Mutation	novel	E347K	0.27
SKCM	chr3	123914888	Nonsense_Mutation	NA	S877*	0.39
SKCM	chr3	123915454	Silent	NA	S688S	0.5
SKCM	chr3	123947073	Nonsense_Mutation	rs776294290	R318*	0.35
SKCM	chr3	123915070	Silent	NA	L816L	0.24
SKCM	chr3	123915686	Missense_Mutation	NA	S611F	0.35
SKCM	chr3	123915246	Missense_Mutation	rs779343412	P758S	0.47
SKCM	chr3	123947237	Missense_Mutation	NA	S263L	0.29
SKCM	chr3	123915029	Missense_Mutation	novel	T830I	0.15
SKCM	chr3	123944979	Missense_Mutation	NA	I412V	0.38
SKCM	chr3	123947073	Nonsense_Mutation	rs776294290	R318*	0.25
STAD	chr3	123948949	Missense_Mutation	NA	K186R	0.35
STAD	chr3	123947264	Missense_Mutation	NA	A254G	0.2
STAD	chr3	123914885	Missense_Mutation	rs763135281	T878M	0.39
STAD	chr3	123915196	Silent	NA	G774G	0.09
STAD	chr3	123946858	Frame_Shift_Del	novel	*V390Lfs4**	0.09
STAD	chr3	123946880	Frame_Shift_Del	NA	*N382Mfs2**	0.32
STAD	chr3	123915001	Silent	NA	C839C	0.08
STAD	chr3	123915446	Missense_Mutation	novel	G691D	0.15
STAD	chr3	123914956	Silent	NA	G854G	0.07
TGCT	chr3	123946839	Missense_Mutation	novel	L396M	0.17
THCA	chr3	123915312	Frame_Shift_Ins	novel	*T736Yfs31**	0.04
UCEC	chr3	123956800	Splice_Region	novel		0.2
UCEC	chr3	123949030	Missense_Mutation	NA	R159I	0.29
UCEC	chr3	123956498	Intron	novel		0.38
UCEC	chr3	123914138	3'UTR	novel		0.22
UCEC	chr3	123946997	Missense_Mutation	novel	A343V	0.16
UCEC	chr3	123956266	Intron	novel		0.16
UCEC	chr3	123947030	Missense_Mutation	rs370975951	R332Q	0.54
UCEC	chr3	123947087	Missense_Mutation	novel	Y313F	0.3
UCEC	chr3	123956033	Intron	NA		0.57
UCEC	chr3	123955980	Intron	novel		0.48
UCEC	chr3	123946996	Silent	novel	A343A	0.4
UCEC	chr3	123956294	Intron	novel		0.44
UCEC	chr3	123956723	Intron	rs371420050		0.34
UCEC	chr3	123946819	Silent	novel	A402A	0.18
UCEC	chr3	123956180	Intron	novel		0.1
UCEC	chr3	123915040	Silent	NA	I826I	0.21
UCEC	chr3	123915259	Silent	novel	S753S	0.1
UCEC	chr3	123956562	Intron	novel		0.47
UCEC	chr3	123914063	3'UTR	novel		0.21
UCEC	chr3	123915270	Missense_Mutation	novel	S750A	0.39
UCEC	chr3	123947030	Missense_Mutation	rs370975951	R332Q	0.46
UCEC	chr3	123956518	Intron	novel		0.15
UCEC	chr3	123946921	Silent	novel	V368V	0.44
UCEC	chr3	123946920	Nonsense_Mutation	rs200601158	R369*	0.34
UCEC	chr3	123914063	3'UTR	rs149565371		0.24
UCEC	chr3	123931439	Missense_Mutation	novel	E512G	0.24
UCEC	chr3	123956530	Intron	novel		0.38
UCEC	chr3	123915083	Missense_Mutation	novel	D812G	0.31
UCEC	chr3	123915269	Missense_Mutation	novel	S750L	0.33
UCEC	chr3	123956410	Frame_Shift_Ins	novel	*I83Nfs5**	0.28
UCEC	chr3	123946880	Frame_Shift_Del	NA	*N382Mfs2**	0.31
UCEC	chr3	123946979	Missense_Mutation	novel	C349Y	0.35
UCEC	chr3	123946879	Frame_Shift_Ins	novel	*N382Kfs7**	0.34
UCEC	chr3	123931235	Splice_Site	novel	X556_splice	0.16
UCEC	chr3	123955945	Intron	novel		0.14
UCEC	chr3	123931146	Silent	NA	L585L	0.33
UCEC	chr3	123956285	Intron	novel		0.25
UCEC	chr3	123956836	Intron	novel		0.56
UCEC	chr3	123949121	Missense_Mutation	novel	N129D	0.29
UCEC	chr3	123946858	Silent	NA	K389K	0.24
UCEC	chr3	123956007	Intron	novel		0.48
UCEC	chr3	123955986	Intron	novel		0.24
UCEC	chr3	123956216	Intron	novel		0.42
UCEC	chr3	123947207	Missense_Mutation	novel	S273N	0.48
UCEC	chr3	123956740	Missense_Mutation	rs532208816	A77V	0.42
UCEC	chr3	123956139	Intron	novel		0.31
UCEC	chr3	123944852	Missense_Mutation	rs72964825	R454Q	0.29
UCEC	chr3	123933716	Missense_Mutation	NA	Q468H	0.21
UCEC	chr3	123947072	Missense_Mutation	rs766062605	R318Q	0.31
UCEC	chr3	123948925	Missense_Mutation	novel	A194D	0.3
UCEC	chr3	123956355	Splice_Region	novel	Q101Q	0.44
UCEC	chr3	123914063	3'UTR	novel		0.38
UCEC	chr3	123915259	Silent	novel	S753S	0.13
UCEC	chr3	123956037	Intron	rs768207248		0.43
UCEC	chr3	123946839	Missense_Mutation	novel	L396V	0.04
UCEC	chr3	123915684	Missense_Mutation	novel	D612N	0.19
UCEC	chr3	123947142	Missense_Mutation	novel	L295M	0.28
UCEC	chr3	123946997	Missense_Mutation	novel	A343V	0.46
UCEC	chr3	123956033	Intron	NA		0.42
UCEC	chr3	123915704	Missense_Mutation	NA	S605N	0.32
UCEC	chr3	123947072	Missense_Mutation	rs766062605	R318Q	0.43
UCEC	chr3	123948948	Missense_Mutation	novel	K186N	0.42
UCEC	chr3	123955903	Intron	rs777785610		0.3
UCEC	chr3	123956739	Splice_Site	rs780060142	X77_splice	0.29

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
GBM	DEL	0.0849	0.00094652
KIRC	DEL	0.197	0.11092
LGG	DEL	0.0604	0.04374

Survival Analysis

Cancer	P-value	Q-value
THYM	0.049	Kaplan-Meier Survival Analysis
KIRC	0.0001	Kaplan-Meier Survival Analysis
SARC	0.026	Kaplan-Meier Survival Analysis
MESO	0.00058	Kaplan-Meier Survival Analysis
ACC	0.0005	Kaplan-Meier Survival Analysis
HNSC	0.0094	Kaplan-Meier Survival Analysis
SKCM	0.022	Kaplan-Meier Survival Analysis
PRAD	0.0046	Kaplan-Meier Survival Analysis
COAD	0.043	Kaplan-Meier Survival Analysis
PCPG	0.016	Kaplan-Meier Survival Analysis
BLCA	0.00011	Kaplan-Meier Survival Analysis
READ	0.014	Kaplan-Meier Survival Analysis
KICH	0.025	Kaplan-Meier Survival Analysis
GBM	0.027	Kaplan-Meier Survival Analysis
LIHC	0.0086	Kaplan-Meier Survival Analysis
LGG	0.00013	Kaplan-Meier Survival Analysis

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000175455 (Gene tree)
Gene ID: 64770
Gene Symbol: CCDC14
Alias: FLJ12892|DKFZp434L1050
Full Name: coiled-coil domain containing 14
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 74,057 bases
Position: chr3:123,887,353-123,961,409
Accession: 25766
RBP type: non-canonical RBP
Summary: (Coiled-Coil Domain Containing 14) is a Protein Coding gene.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000485727	CCDC14-217	7917	XM_005247714	ENSP00000418002	753 (aa)	XP_005247771	Q49A88
ENST00000495381	CCDC14-222	3993	-	-	- (aa)	-	-
ENST00000310351	CCDC14-201	3111	-	ENSP00000312031	864 (aa)	-	A0A0A0MR27
ENST00000433542	CCDC14-207	3260	-	ENSP00000395706	912 (aa)	-	Q49A88
ENST00000478956	CCDC14-214	555	-	-	- (aa)	-	-
ENST00000417438	CCDC14-204	548	-	ENSP00000398148	64 (aa)	-	C9J6B5
ENST00000489746	CCDC14-221	6476	XM_005247713	ENSP00000418403	753 (aa)	XP_005247770	Q49A88
ENST00000471054	CCDC14-212	544	-	-	- (aa)	-	-
ENST00000488653	CCDC14-220	4156	-	ENSP00000420180	912 (aa)	-	Q49A88
ENST00000485949	CCDC14-218	439	-	-	- (aa)	-	-
ENST00000479903	CCDC14-215	770	-	ENSP00000420768	257 (aa)	-	H7C5T3
ENST00000409697	CCDC14-203	2962	XM_005247710	ENSP00000386866	905 (aa)	XP_005247767	J3QT39
ENST00000438440	CCDC14-210	783	-	-	- (aa)	-	-
ENST00000435910	CCDC14-209	864	-	ENSP00000407820	37 (aa)	-	H7C2U5
ENST00000483247	CCDC14-216	697	-	-	- (aa)	-	-
ENST00000487498	CCDC14-219	615	-	-	- (aa)	-	-
ENST00000426152	CCDC14-206	735	-	ENSP00000414655	174 (aa)	-	C9JSI8
ENST00000463996	CCDC14-211	374	-	-	- (aa)	-	-
ENST00000409657	CCDC14-202	3815	-	ENSP00000386481	52 (aa)	-	H3BM06
ENST00000419247	CCDC14-205	1221	XM_017007059	ENSP00000400957	312 (aa)	XP_016862548	C9JU82
ENST00000434954	CCDC14-208	567	-	ENSP00000387962	117 (aa)	-	C9JWZ1
ENST00000477268	CCDC14-213	589	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000175455's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000175455	Alcohol Drinking	3.18361598087081E-12	-
ENSG00000175455	Fluoroquinolones	2E-7	28043905
ENSG00000175455	Chemical and Drug Induced Liver Injury	2E-7	28043905

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000175455	rs13089785	3	123935062	A	Intelligence (MTAG)	29326435	[0.011-0.023] unit decrease	0.017276917	EFO_0004337
ENSG00000175455	rs191153876	3	123918335	?	Drug-induced liver injury (fluoroquinolones)	28043905	3.46-15.5	7.33	EFO_0007920\|EFO_0004228
ENSG00000175455	rs13062100	3	123955490	?	General cognitive ability	29844566	z-score decrease	5.434	EFO_0004337

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000175455's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	17043677.25416956.26297806.26496610.26638075.	IPI	Function
GO:0005813	centrosome	21399614.	IDA	Component
GO:0021762	substantia nigra development	22926577.	HEP	Process
GO:0034451	centriolar satellite	26297806.	IDA	Component
GO:0071539	protein localization to centrosome	26297806.	IMP	Process

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.