EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr5176643252Missense_MutationnovelH62Q0.43IF4E
BLCAchr5176645436Silentrs199960344V178V0.35
BLCAchr5176643158Missense_MutationNAT31I0.44IF4E
BRCAchr5176643218In_Frame_InsNAT51_G52insR0.28IF4E
CESCchr5176645936Missense_MutationnovelA229S0.09
COADchr5176643219Frame_Shift_DelNAG53Afs*1100.36IF4E
COADchr5176645503Missense_MutationNAV201M0.31
COADchr5176643218Missense_Mutationrs779126438T51M0.27IF4E
ESCAchr5176643673Missense_Mutationrs765322594R79W0.5IF4E
GBMchr5176643179Missense_MutationNAS38C0.33IF4E
HNSCchr5176643094Missense_MutationnovelE10K0.32IF4E
HNSCchr5176645480Missense_MutationnovelR193K0.32
LIHCchr5176645877Missense_MutationNAK209R0.18
LIHCchr5176643691Missense_MutationNAL85V0.51IF4E
LIHCchr5176643172Missense_MutationNAP36T0.37IF4E
LIHCchr5176643685Missense_MutationnovelD83Y0.29IF4E
LUADchr5176643181Missense_MutationNAP39T0.28IF4E
LUADchr5176645501Missense_MutationNAG200V0.43
LUADchr5176643734Missense_MutationnovelA99E0.42IF4E
LUADchr5176643228SilentNAP54P0.19
LUADchr5176643646SilentnovelL70L0.8
LUADchr5176645391SilentnovelI163I0.31
PAADchr5176645486Missense_MutationNAA195V0.04
READchr51766460113'UTRnovel0.24
READchr51766427735'UTRnovel0.31
SARCchr5176643155Missense_MutationnovelP30L0.38IF4E
SARCchr5176643218Missense_Mutationrs779126438T51M0.47IF4E
SKCMchr5176645428Missense_MutationNAG176R0.54
SKCMchr5176645430SilentNAG176G0.27
SKCMchr5176643206Missense_MutationNAG47E0.12IF4E
SKCMchr5176645466Silentrs115095188I188I0.08
STADchr5176643673Missense_Mutationrs765322594R79W0.45IF4E
STADchr5176643673Missense_Mutationrs765322594R79W0.2IF4E
STADchr5176643735Splice_Siters557333631X99_splice0.09
STADchr5176645486Missense_MutationNAA195V0.29
STADchr5176643675SilentnovelR79R0.5
STADchr5176643212Missense_MutationNAA49V0.14IF4E
STADchr5176643218Missense_Mutationrs779126438T51M0.1IF4E
STADchr5176643249Silentrs766202600L61L0.3
STADchr5176643194Missense_MutationnovelL43R0.08IF4E
STADchr5176643195SilentnovelL43L0.08
THYMchr51766460513'UTRnovel0.37
UCECchr5176644384Missense_MutationnovelS102I0.54IF4E
UCECchr5176645868Missense_Mutationrs369631741R206H0.19
UCECchr5176643664Missense_MutationnovelD76N0.24IF4E
UCECchr51766421005'UTRnovel0.17
UCECchr5176643727Missense_MutationnovelF97V0.47IF4E
UCECchr5176645208Missense_MutationnovelR147C0.17
UCECchr5176645447Missense_MutationNAR182H0.71
UCECchr5176643163Nonsense_MutationnovelE33*0.3IF4E
UCECchr5176645447Missense_MutationNAR182H0.24
UCECchr51766421585'UTRnovel0.1
UCECchr5176645143Missense_MutationnovelP125H0.43
UCECchr5176645502Silentrs760116008G200G0.44
UCECchr5176643668Missense_Mutationrs373687912R77H0.51IF4E
UCECchr5176643735Splice_SitenovelX99_splice0.4
UCECchr5176645902Missense_MutationnovelK217N0.46
UCECchr5176643141SilentnovelA25A0.46
UCECchr5176645498Missense_Mutationrs759283330A199V0.31

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
KIRCAMP0.59092.1944e-60
KIRPAMP0.11460.069756
KIRPDEL0.03820.11554
LGGDEL0.08381.86e-07
LUADAMP0.17250.24967
LUSCDEL0.59480.002071
MESODEL0.11490.20184
PRADAMP0.03250.16448
SKCMAMP0.11440.23703
THCADEL00.23456

Survival Analysis
CancerP-value Q-value
ACC0.012

Kaplan-Meier Survival Analysis

BRCA0.036

Kaplan-Meier Survival Analysis

GBM0.032

Kaplan-Meier Survival Analysis

LGG0.00076

Kaplan-Meier Survival Analysis

CHOL0.026

Kaplan-Meier Survival Analysis

  • Description
  • RBDs
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Paralogs
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000175766 (Gene tree)
Gene ID
253314
Gene Symbol
EIF4E1B
Alias
FLJ36951
Full Name
eukaryotic translation initiation factor 4E family member 1B
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
16,024 bases
Position
chr5:176,630,618-176,646,641
Accession
33179
RBP type
canonical RBP
Summary
(Eukaryotic Translation Initiation Factor 4E Family Member 1B) is a Protein Coding gene. Among its related pathways are Regulation of lipid metabolism Insulin signaling-generic cascades and mTOR signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include RNA binding and translation initiation factor activity. An important paralog of this gene is EIF4E.
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000323714IF4EPF01652.187.7e-5311
ENSP00000427633IF4EPF01652.187.7e-5311
ENSP00000497422IF4EPF01652.187.7e-5311
ENSP00000422420IF4EPF01652.189.9e-3311

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
18631138Translational control in early development: CPEB, P-bodies and germinal granules.Biochem Soc Trans2008 AugStandart Ndoi: 10.1042/BST0360671.
25463438Distinct features of cap binding by eIF4E1b proteins.J Mol Biol2015 Jan 30Kubacka Ddoi: 10.1016/j.jmb.2014.11.009
17942399CPEB interacts with an ovary-specific eIF4E and 4E-T in early Xenopus oocytes.J Biol Chem2007 Dec 28Minshall N-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000505497EIF4E1B-204514-ENSP00000422420171 (aa)-H0Y8X3
ENST00000515458EIF4E1B-2082836--- (aa)--
ENST00000318682EIF4E1B-2011974XM_011534499ENSP00000323714242 (aa)XP_011532801A6NMX2
ENST00000510660EIF4E1B-206581-ENSP0000042100990 (aa)-D6RHE2
ENST00000510473EIF4E1B-205533--- (aa)--
ENST00000504597EIF4E1B-2031676-ENSP00000427633242 (aa)-A6NMX2
ENST00000647833EIF4E1B-2092137-ENSP00000497422242 (aa)-UPI0001572CC7
ENST00000503895EIF4E1B-202564--- (aa)--
ENST00000512734EIF4E1B-207561--- (aa)--
Gene Model
Click here to download ENSG00000175766's gene model file
Pathways
Pathway IDPathway NameSource
hsa01521EGFR tyrosine kinase inhibitor resistanceKEGG
hsa03013RNA transportKEGG
hsa04066HIF-1 signaling pathwayKEGG
hsa04150mTOR signaling pathwayKEGG
hsa04151PI3K-Akt signaling pathwayKEGG
hsa04211Longevity regulating pathwayKEGG
hsa04910Insulin signaling pathwayKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000175766's network

* RBP PPI network refers to all genes directly bind to RBP
Paralogs
Ensembl IDGene SymbolCoverageIdentiy ParalogGene SymbolCoverageIdentiy
ENSG00000175766EIF4E1B7574.033ENSG00000151247EIF4E8374.033
ENSG00000175766EIF4E1B9331.602ENSG00000135930EIF4E28434.574
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000175766EIF4E1B9871.888ENSAMEG00000007196EIF4E1B8577.103Ailuropoda_melanoleuca
ENSG00000175766EIF4E1B7581.215ENSACAG00000007055EIF4E1B9781.215Anolis_carolinensis
ENSG00000175766EIF4E1B10089.256ENSANAG00000024720EIF4E1B10088.843Aotus_nancymaae
ENSG00000175766EIF4E1B8155.838ENSAMXG00000043293eif4e1b9155.838Astyanax_mexicanus
ENSG00000175766EIF4E1B7885.714ENSBTAG00000003103EIF4E1B8285.714Bos_taurus
ENSG00000175766EIF4E1B10088.843ENSCJAG00000007291EIF4E1B10088.430Callithrix_jacchus
ENSG00000175766EIF4E1B9782.979ENSCAFG00000016643EIF4E1B9983.404Canis_familiaris
ENSG00000175766EIF4E1B7591.713ENSCAFG00020011562EIF4E1B8391.713Canis_lupus_dingo
ENSG00000175766EIF4E1B7290.286ENSCHIG00000006321EIF4E1B9090.286Capra_hircus
ENSG00000175766EIF4E1B10070.248ENSTSYG00000025856EIF4E1B10069.835Carlito_syrichta
ENSG00000175766EIF4E1B8377.451ENSCAPG00000011182EIF4E1B9177.451Cavia_aperea
ENSG00000175766EIF4E1B8885.514ENSCPOG00000004429EIF4E1B9780.753Cavia_porcellus
ENSG00000175766EIF4E1B10090.083ENSCCAG00000008488EIF4E1B10089.256Cebus_capucinus
ENSG00000175766EIF4E1B10093.033ENSCATG00000036544EIF4E1B10093.033Cercocebus_atys
ENSG00000175766EIF4E1B9884.100ENSCLAG00000013384EIF4E1B9290.625Chinchilla_lanigera
ENSG00000175766EIF4E1B10090.283ENSCSAG00000009203EIF4E1B10090.688Chlorocebus_sabaeus
ENSG00000175766EIF4E1B5581.061ENSCPBG00000022627EIF4E1B10081.061Chrysemys_picta_bellii
ENSG00000175766EIF4E1B7562.431ENSCING00000004199-8062.431Ciona_intestinalis
ENSG00000175766EIF4E1B10093.033ENSCANG00000031424EIF4E1B10094.672Colobus_angolensis_palliatus
ENSG00000175766EIF4E1B8480.392ENSCGRG00001003887Eif4e1b9688.811Cricetulus_griseus_chok1gshd
ENSG00000175766EIF4E1B7572.376ENSDARG00000014565eif4e1b9972.376Danio_rerio
ENSG00000175766EIF4E1B9780.913ENSDNOG00000032189EIF4E1B7788.235Dasypus_novemcinctus
ENSG00000175766EIF4E1B8780.095ENSDORG00000016043Eif4e1b8787.629Dipodomys_ordii
ENSG00000175766EIF4E1B7261.714ENSEBUG00000014777eif4e1b8561.714Eptatretus_burgeri
ENSG00000175766EIF4E1B9983.951ENSEASG00005012081EIF4E1B9983.951Equus_asinus_asinus
ENSG00000175766EIF4E1B9883.750ENSECAG00000022357EIF4E1B8784.583Equus_caballus
ENSG00000175766EIF4E1B7577.348ENSEEUG00000005920EIF4E1B9477.348Erinaceus_europaeus
ENSG00000175766EIF4E1B7474.157ENSELUG00000021695eif4e1b7674.157Esox_lucius
ENSG00000175766EIF4E1B9981.048ENSFCAG00000003074EIF4E1B9981.707Felis_catus
ENSG00000175766EIF4E1B7581.215ENSFALG00000008607EIF4E1B8281.215Ficedula_albicollis
ENSG00000175766EIF4E1B8887.383ENSFDAG00000008704EIF4E1B9881.743Fukomys_damarensis
ENSG00000175766EIF4E1B9963.306ENSGALG00000026037EIF4E1B7179.330Gallus_gallus
ENSG00000175766EIF4E1B5982.517ENSGAGG00000012675EIF4E1B9682.517Gopherus_agassizii
ENSG00000175766EIF4E1B10098.889ENSGGOG00000015854EIF4E1B10098.760Gorilla_gorilla
ENSG00000175766EIF4E1B8889.252ENSHGLG00000016879-9285.841Heterocephalus_glaber_female
ENSG00000175766EIF4E1B8889.412ENSHGLG00100012839-9789.412Heterocephalus_glaber_male
ENSG00000175766EIF4E1B7574.586ENSIPUG00000020654eif4e1b9270.707Ictalurus_punctatus
ENSG00000175766EIF4E1B9879.253ENSSTOG00000002002EIF4E1B10079.253Ictidomys_tridecemlineatus
ENSG00000175766EIF4E1B8882.160ENSJJAG00000017541Eif4e1b8782.160Jaculus_jaculus
ENSG00000175766EIF4E1B7570.166ENSLOCG00000011832eif4e1b8270.166Lepisosteus_oculatus
ENSG00000175766EIF4E1B7378.212ENSLAFG00000027919EIF4E1B9978.212Loxodonta_africana
ENSG00000175766EIF4E1B10092.276ENSMFAG00000031726EIF4E1B9996.682Macaca_fascicularis
ENSG00000175766EIF4E1B10092.276ENSMMUG00000000142EIF4E1B10092.683Macaca_mulatta
ENSG00000175766EIF4E1B10092.276ENSMNEG00000031510EIF4E1B10092.683Macaca_nemestrina
ENSG00000175766EIF4E1B10092.276ENSMLEG00000037281EIF4E1B10092.683Mandrillus_leucophaeus
ENSG00000175766EIF4E1B7581.215ENSMGAG00000004602EIF4E1B8381.215Meleagris_gallopavo
ENSG00000175766EIF4E1B10069.478ENSMICG00000047427EIF4E1B10069.880Microcebus_murinus
ENSG00000175766EIF4E1B5083.471ENSMODG00000016941-9583.471Monodelphis_domestica
ENSG00000175766EIF4E1B9075.115ENSMODG00000005097-9876.056Monodelphis_domestica
ENSG00000175766EIF4E1B9770.638MGP_CAROLIEiJ_G0018546Eif4e1b10070.085Mus_caroli
ENSG00000175766EIF4E1B9172.727ENSMUSG00000074895Eif4e1b9871.171Mus_musculus
ENSG00000175766EIF4E1B9671.552MGP_PahariEiJ_G0019611Eif4e1b10072.816Mus_pahari
ENSG00000175766EIF4E1B9172.273MGP_SPRETEiJ_G0019426Eif4e1b9871.171Mus_spretus
ENSG00000175766EIF4E1B9881.405ENSMPUG00000012507EIF4E1B9280.992Mustela_putorius_furo
ENSG00000175766EIF4E1B9980.328ENSMLUG00000001437EIF4E1B8587.143Myotis_lucifugus
ENSG00000175766EIF4E1B10097.778ENSNLEG00000012532EIF4E1B10097.107Nomascus_leucogenys
ENSG00000175766EIF4E1B7371.186ENSMEUG00000002671EIF4E1B9671.186Notamacropus_eugenii
ENSG00000175766EIF4E1B5792.806ENSOPRG00000008875EIF4E1B9392.806Ochotona_princeps
ENSG00000175766EIF4E1B9779.079ENSODEG00000009390EIF4E1B9979.079Octodon_degus
ENSG00000175766EIF4E1B7691.848ENSOCUG00000007864EIF4E1B8789.175Oryctolagus_cuniculus
ENSG00000175766EIF4E1B8786.256ENSOGAG00000005844EIF4E1B10086.256Otolemur_garnettii
ENSG00000175766EIF4E1B7987.500ENSOARG00000002979EIF4E1B8387.500Ovis_aries
ENSG00000175766EIF4E1B9898.312ENSPPAG00000036530EIF4E1B9598.312Pan_paniscus
ENSG00000175766EIF4E1B10082.591ENSPPRG00000011119EIF4E1B10081.781Panthera_pardus
ENSG00000175766EIF4E1B9882.645ENSPTIG00000012304EIF4E1B9982.231Panthera_tigris_altaica
ENSG00000175766EIF4E1B10097.934ENSPTRG00000028481EIF4E1B10097.934Pan_troglodytes
ENSG00000175766EIF4E1B10091.870ENSPANG00000014775EIF4E1B10092.276Papio_anubis
ENSG00000175766EIF4E1B7572.928ENSPKIG00000025064eif4e1b8572.928Paramormyrops_kingsleyae
ENSG00000175766EIF4E1B7682.609ENSPCIG00000018442EIF4E1B7282.609Phascolarctos_cinereus
ENSG00000175766EIF4E1B7596.133ENSPPYG00000016077-8396.133Pongo_abelii
ENSG00000175766EIF4E1B5185.366ENSPCAG00000003618-10085.366Procavia_capensis
ENSG00000175766EIF4E1B9878.243ENSPCOG00000019904EIF4E1B9978.903Propithecus_coquereli
ENSG00000175766EIF4E1B7392.614ENSPVAG00000017039EIF4E1B9681.731Pteropus_vampyrus
ENSG00000175766EIF4E1B7573.481ENSPNAG00000000195eif4e1b8473.481Pygocentrus_nattereri
ENSG00000175766EIF4E1B10092.245ENSRBIG00000039242EIF4E1B9996.682Rhinopithecus_bieti
ENSG00000175766EIF4E1B10092.245ENSRROG00000042084EIF4E1B10093.469Rhinopithecus_roxellana
ENSG00000175766EIF4E1B10088.430ENSSBOG00000030710EIF4E1B10088.017Saimiri_boliviensis_boliviensis
ENSG00000175766EIF4E1B7682.703ENSSHAG00000007864EIF4E1B9382.703Sarcophilus_harrisii
ENSG00000175766EIF4E1B8169.744ENSSFOG00015005488eif4e1b8969.744Scleropages_formosus
ENSG00000175766EIF4E1B5479.348ENSSARG00000010425-8379.592Sorex_araneus
ENSG00000175766EIF4E1B8871.362ENSSPUG00000006304EIF4E1B9979.545Sphenodon_punctatus
ENSG00000175766EIF4E1B9878.601ENSSSCG00000014052EIF4E1B9978.189Sus_scrofa
ENSG00000175766EIF4E1B6980.723ENSTGUG00000000504EIF4E1B9980.723Taeniopygia_guttata
ENSG00000175766EIF4E1B7078.824ENSTBEG00000001631EIF4E1B9478.824Tupaia_belangeri
ENSG00000175766EIF4E1B7487.778ENSTTRG00000014026EIF4E1B8587.778Tursiops_truncatus
ENSG00000175766EIF4E1B9384.444ENSUAMG00000022136EIF4E1B9888.462Ursus_americanus
ENSG00000175766EIF4E1B7393.182ENSVVUG00000001475EIF4E1B7393.182Vulpes_vulpes
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000340RNA 7-methylguanosine cap binding21873635.IBAFunction
GO:0003743translation initiation factor activity21873635.IBAFunction
GO:0005845mRNA cap binding complex-ISSComponent
GO:0006413translational initiation-IEAProcess
GO:0006417regulation of translation-IEAProcess
GO:0016281eukaryotic translation initiation factor 4F complex21873635.IBAComponent
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