EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr5	176643252	Missense_Mutation	novel	H62Q	0.43	IF4E
BLCA	chr5	176645436	Silent	rs199960344	V178V	0.35
BLCA	chr5	176643158	Missense_Mutation	NA	T31I	0.44	IF4E
BRCA	chr5	176643218	In_Frame_Ins	NA	T51_G52insR	0.28	IF4E
CESC	chr5	176645936	Missense_Mutation	novel	A229S	0.09
COAD	chr5	176643219	Frame_Shift_Del	NA	*G53Afs110**	0.36	IF4E
COAD	chr5	176645503	Missense_Mutation	NA	V201M	0.31
COAD	chr5	176643218	Missense_Mutation	rs779126438	T51M	0.27	IF4E
ESCA	chr5	176643673	Missense_Mutation	rs765322594	R79W	0.5	IF4E
GBM	chr5	176643179	Missense_Mutation	NA	S38C	0.33	IF4E
HNSC	chr5	176643094	Missense_Mutation	novel	E10K	0.32	IF4E
HNSC	chr5	176645480	Missense_Mutation	novel	R193K	0.32
LIHC	chr5	176645877	Missense_Mutation	NA	K209R	0.18
LIHC	chr5	176643691	Missense_Mutation	NA	L85V	0.51	IF4E
LIHC	chr5	176643172	Missense_Mutation	NA	P36T	0.37	IF4E
LIHC	chr5	176643685	Missense_Mutation	novel	D83Y	0.29	IF4E
LUAD	chr5	176643181	Missense_Mutation	NA	P39T	0.28	IF4E
LUAD	chr5	176645501	Missense_Mutation	NA	G200V	0.43
LUAD	chr5	176643734	Missense_Mutation	novel	A99E	0.42	IF4E
LUAD	chr5	176643228	Silent	NA	P54P	0.19
LUAD	chr5	176643646	Silent	novel	L70L	0.8
LUAD	chr5	176645391	Silent	novel	I163I	0.31
PAAD	chr5	176645486	Missense_Mutation	NA	A195V	0.04
READ	chr5	176646011	3'UTR	novel		0.24
READ	chr5	176642773	5'UTR	novel		0.31
SARC	chr5	176643155	Missense_Mutation	novel	P30L	0.38	IF4E
SARC	chr5	176643218	Missense_Mutation	rs779126438	T51M	0.47	IF4E
SKCM	chr5	176645428	Missense_Mutation	NA	G176R	0.54
SKCM	chr5	176645430	Silent	NA	G176G	0.27
SKCM	chr5	176643206	Missense_Mutation	NA	G47E	0.12	IF4E
SKCM	chr5	176645466	Silent	rs115095188	I188I	0.08
STAD	chr5	176643673	Missense_Mutation	rs765322594	R79W	0.45	IF4E
STAD	chr5	176643673	Missense_Mutation	rs765322594	R79W	0.2	IF4E
STAD	chr5	176643735	Splice_Site	rs557333631	X99_splice	0.09
STAD	chr5	176645486	Missense_Mutation	NA	A195V	0.29
STAD	chr5	176643675	Silent	novel	R79R	0.5
STAD	chr5	176643212	Missense_Mutation	NA	A49V	0.14	IF4E
STAD	chr5	176643218	Missense_Mutation	rs779126438	T51M	0.1	IF4E
STAD	chr5	176643249	Silent	rs766202600	L61L	0.3
STAD	chr5	176643194	Missense_Mutation	novel	L43R	0.08	IF4E
STAD	chr5	176643195	Silent	novel	L43L	0.08
THYM	chr5	176646051	3'UTR	novel		0.37
UCEC	chr5	176644384	Missense_Mutation	novel	S102I	0.54	IF4E
UCEC	chr5	176645868	Missense_Mutation	rs369631741	R206H	0.19
UCEC	chr5	176643664	Missense_Mutation	novel	D76N	0.24	IF4E
UCEC	chr5	176642100	5'UTR	novel		0.17
UCEC	chr5	176643727	Missense_Mutation	novel	F97V	0.47	IF4E
UCEC	chr5	176645208	Missense_Mutation	novel	R147C	0.17
UCEC	chr5	176645447	Missense_Mutation	NA	R182H	0.71
UCEC	chr5	176643163	Nonsense_Mutation	novel	E33*	0.3	IF4E
UCEC	chr5	176645447	Missense_Mutation	NA	R182H	0.24
UCEC	chr5	176642158	5'UTR	novel		0.1
UCEC	chr5	176645143	Missense_Mutation	novel	P125H	0.43
UCEC	chr5	176645502	Silent	rs760116008	G200G	0.44
UCEC	chr5	176643668	Missense_Mutation	rs373687912	R77H	0.51	IF4E
UCEC	chr5	176643735	Splice_Site	novel	X99_splice	0.4
UCEC	chr5	176645902	Missense_Mutation	novel	K217N	0.46
UCEC	chr5	176643141	Silent	novel	A25A	0.46
UCEC	chr5	176645498	Missense_Mutation	rs759283330	A199V	0.31

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRC	AMP	0.5909	2.1944e-60
KIRP	AMP	0.1146	0.069756
KIRP	DEL	0.0382	0.11554
LGG	DEL	0.0838	1.86e-07
LUAD	AMP	0.1725	0.24967
LUSC	DEL	0.5948	0.002071
MESO	DEL	0.1149	0.20184
PRAD	AMP	0.0325	0.16448
SKCM	AMP	0.1144	0.23703
THCA	DEL	0	0.23456

Survival Analysis

Cancer	P-value	Q-value
ACC	0.012	Kaplan-Meier Survival Analysis
BRCA	0.036	Kaplan-Meier Survival Analysis
GBM	0.032	Kaplan-Meier Survival Analysis
LGG	0.00076	Kaplan-Meier Survival Analysis
CHOL	0.026	Kaplan-Meier Survival Analysis

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000175766 (Gene tree)
Gene ID: 253314
Gene Symbol: EIF4E1B
Alias: FLJ36951
Full Name: eukaryotic translation initiation factor 4E family member 1B
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 16,024 bases
Position: chr5:176,630,618-176,646,641
Accession: 33179
RBP type: canonical RBP
Summary: (Eukaryotic Translation Initiation Factor 4E Family Member 1B) is a Protein Coding gene. Among its related pathways are Regulation of lipid metabolism Insulin signaling-generic cascades and mTOR signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include RNA binding and translation initiation factor activity. An important paralog of this gene is EIF4E.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000323714	IF4E	PF01652.18	7.7e-53	1	1
ENSP00000427633	IF4E	PF01652.18	7.7e-53	1	1
ENSP00000497422	IF4E	PF01652.18	7.7e-53	1	1
ENSP00000422420	IF4E	PF01652.18	9.9e-33	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
18631138	Translational control in early development: CPEB, P-bodies and germinal granules.	Biochem Soc Trans	2008 Aug	Standart N	doi: 10.1042/BST0360671.
25463438	Distinct features of cap binding by eIF4E1b proteins.	J Mol Biol	2015 Jan 30	Kubacka D	doi: 10.1016/j.jmb.2014.11.009
17942399	CPEB interacts with an ovary-specific eIF4E and 4E-T in early Xenopus oocytes.	J Biol Chem	2007 Dec 28	Minshall N	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000505497	EIF4E1B-204	514	-	ENSP00000422420	171 (aa)	-	H0Y8X3
ENST00000515458	EIF4E1B-208	2836	-	-	- (aa)	-	-
ENST00000318682	EIF4E1B-201	1974	XM_011534499	ENSP00000323714	242 (aa)	XP_011532801	A6NMX2
ENST00000510660	EIF4E1B-206	581	-	ENSP00000421009	90 (aa)	-	D6RHE2
ENST00000510473	EIF4E1B-205	533	-	-	- (aa)	-	-
ENST00000504597	EIF4E1B-203	1676	-	ENSP00000427633	242 (aa)	-	A6NMX2
ENST00000647833	EIF4E1B-209	2137	-	ENSP00000497422	242 (aa)	-	UPI0001572CC7
ENST00000503895	EIF4E1B-202	564	-	-	- (aa)	-	-
ENST00000512734	EIF4E1B-207	561	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000175766's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa01521	EGFR tyrosine kinase inhibitor resistance	KEGG
hsa03013	RNA transport	KEGG
hsa04066	HIF-1 signaling pathway	KEGG
hsa04150	mTOR signaling pathway	KEGG
hsa04151	PI3K-Akt signaling pathway	KEGG
hsa04211	Longevity regulating pathway	KEGG
hsa04910	Insulin signaling pathway	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000175766's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000175766	EIF4E1B	75	74.033	ENSG00000151247	EIF4E	83	74.033
ENSG00000175766	EIF4E1B	93	31.602	ENSG00000135930	EIF4E2	84	34.574

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000175766	EIF4E1B	98	71.888	ENSAMEG00000007196	EIF4E1B	85	77.103	Ailuropoda_melanoleuca
ENSG00000175766	EIF4E1B	75	81.215	ENSACAG00000007055	EIF4E1B	97	81.215	Anolis_carolinensis
ENSG00000175766	EIF4E1B	100	89.256	ENSANAG00000024720	EIF4E1B	100	88.843	Aotus_nancymaae
ENSG00000175766	EIF4E1B	81	55.838	ENSAMXG00000043293	eif4e1b	91	55.838	Astyanax_mexicanus
ENSG00000175766	EIF4E1B	78	85.714	ENSBTAG00000003103	EIF4E1B	82	85.714	Bos_taurus
ENSG00000175766	EIF4E1B	100	88.843	ENSCJAG00000007291	EIF4E1B	100	88.430	Callithrix_jacchus
ENSG00000175766	EIF4E1B	97	82.979	ENSCAFG00000016643	EIF4E1B	99	83.404	Canis_familiaris
ENSG00000175766	EIF4E1B	75	91.713	ENSCAFG00020011562	EIF4E1B	83	91.713	Canis_lupus_dingo
ENSG00000175766	EIF4E1B	72	90.286	ENSCHIG00000006321	EIF4E1B	90	90.286	Capra_hircus
ENSG00000175766	EIF4E1B	100	70.248	ENSTSYG00000025856	EIF4E1B	100	69.835	Carlito_syrichta
ENSG00000175766	EIF4E1B	83	77.451	ENSCAPG00000011182	EIF4E1B	91	77.451	Cavia_aperea
ENSG00000175766	EIF4E1B	88	85.514	ENSCPOG00000004429	EIF4E1B	97	80.753	Cavia_porcellus
ENSG00000175766	EIF4E1B	100	90.083	ENSCCAG00000008488	EIF4E1B	100	89.256	Cebus_capucinus
ENSG00000175766	EIF4E1B	100	93.033	ENSCATG00000036544	EIF4E1B	100	93.033	Cercocebus_atys
ENSG00000175766	EIF4E1B	98	84.100	ENSCLAG00000013384	EIF4E1B	92	90.625	Chinchilla_lanigera
ENSG00000175766	EIF4E1B	100	90.283	ENSCSAG00000009203	EIF4E1B	100	90.688	Chlorocebus_sabaeus
ENSG00000175766	EIF4E1B	55	81.061	ENSCPBG00000022627	EIF4E1B	100	81.061	Chrysemys_picta_bellii
ENSG00000175766	EIF4E1B	75	62.431	ENSCING00000004199	-	80	62.431	Ciona_intestinalis
ENSG00000175766	EIF4E1B	100	93.033	ENSCANG00000031424	EIF4E1B	100	94.672	Colobus_angolensis_palliatus
ENSG00000175766	EIF4E1B	84	80.392	ENSCGRG00001003887	Eif4e1b	96	88.811	Cricetulus_griseus_chok1gshd
ENSG00000175766	EIF4E1B	75	72.376	ENSDARG00000014565	eif4e1b	99	72.376	Danio_rerio
ENSG00000175766	EIF4E1B	97	80.913	ENSDNOG00000032189	EIF4E1B	77	88.235	Dasypus_novemcinctus
ENSG00000175766	EIF4E1B	87	80.095	ENSDORG00000016043	Eif4e1b	87	87.629	Dipodomys_ordii
ENSG00000175766	EIF4E1B	72	61.714	ENSEBUG00000014777	eif4e1b	85	61.714	Eptatretus_burgeri
ENSG00000175766	EIF4E1B	99	83.951	ENSEASG00005012081	EIF4E1B	99	83.951	Equus_asinus_asinus
ENSG00000175766	EIF4E1B	98	83.750	ENSECAG00000022357	EIF4E1B	87	84.583	Equus_caballus
ENSG00000175766	EIF4E1B	75	77.348	ENSEEUG00000005920	EIF4E1B	94	77.348	Erinaceus_europaeus
ENSG00000175766	EIF4E1B	74	74.157	ENSELUG00000021695	eif4e1b	76	74.157	Esox_lucius
ENSG00000175766	EIF4E1B	99	81.048	ENSFCAG00000003074	EIF4E1B	99	81.707	Felis_catus
ENSG00000175766	EIF4E1B	75	81.215	ENSFALG00000008607	EIF4E1B	82	81.215	Ficedula_albicollis
ENSG00000175766	EIF4E1B	88	87.383	ENSFDAG00000008704	EIF4E1B	98	81.743	Fukomys_damarensis
ENSG00000175766	EIF4E1B	99	63.306	ENSGALG00000026037	EIF4E1B	71	79.330	Gallus_gallus
ENSG00000175766	EIF4E1B	59	82.517	ENSGAGG00000012675	EIF4E1B	96	82.517	Gopherus_agassizii
ENSG00000175766	EIF4E1B	100	98.889	ENSGGOG00000015854	EIF4E1B	100	98.760	Gorilla_gorilla
ENSG00000175766	EIF4E1B	88	89.252	ENSHGLG00000016879	-	92	85.841	Heterocephalus_glaber_female
ENSG00000175766	EIF4E1B	88	89.412	ENSHGLG00100012839	-	97	89.412	Heterocephalus_glaber_male
ENSG00000175766	EIF4E1B	75	74.586	ENSIPUG00000020654	eif4e1b	92	70.707	Ictalurus_punctatus
ENSG00000175766	EIF4E1B	98	79.253	ENSSTOG00000002002	EIF4E1B	100	79.253	Ictidomys_tridecemlineatus
ENSG00000175766	EIF4E1B	88	82.160	ENSJJAG00000017541	Eif4e1b	87	82.160	Jaculus_jaculus
ENSG00000175766	EIF4E1B	75	70.166	ENSLOCG00000011832	eif4e1b	82	70.166	Lepisosteus_oculatus
ENSG00000175766	EIF4E1B	73	78.212	ENSLAFG00000027919	EIF4E1B	99	78.212	Loxodonta_africana
ENSG00000175766	EIF4E1B	100	92.276	ENSMFAG00000031726	EIF4E1B	99	96.682	Macaca_fascicularis
ENSG00000175766	EIF4E1B	100	92.276	ENSMMUG00000000142	EIF4E1B	100	92.683	Macaca_mulatta
ENSG00000175766	EIF4E1B	100	92.276	ENSMNEG00000031510	EIF4E1B	100	92.683	Macaca_nemestrina
ENSG00000175766	EIF4E1B	100	92.276	ENSMLEG00000037281	EIF4E1B	100	92.683	Mandrillus_leucophaeus
ENSG00000175766	EIF4E1B	75	81.215	ENSMGAG00000004602	EIF4E1B	83	81.215	Meleagris_gallopavo
ENSG00000175766	EIF4E1B	100	69.478	ENSMICG00000047427	EIF4E1B	100	69.880	Microcebus_murinus
ENSG00000175766	EIF4E1B	50	83.471	ENSMODG00000016941	-	95	83.471	Monodelphis_domestica
ENSG00000175766	EIF4E1B	90	75.115	ENSMODG00000005097	-	98	76.056	Monodelphis_domestica
ENSG00000175766	EIF4E1B	97	70.638	MGP_CAROLIEiJ_G0018546	Eif4e1b	100	70.085	Mus_caroli
ENSG00000175766	EIF4E1B	91	72.727	ENSMUSG00000074895	Eif4e1b	98	71.171	Mus_musculus
ENSG00000175766	EIF4E1B	96	71.552	MGP_PahariEiJ_G0019611	Eif4e1b	100	72.816	Mus_pahari
ENSG00000175766	EIF4E1B	91	72.273	MGP_SPRETEiJ_G0019426	Eif4e1b	98	71.171	Mus_spretus
ENSG00000175766	EIF4E1B	98	81.405	ENSMPUG00000012507	EIF4E1B	92	80.992	Mustela_putorius_furo
ENSG00000175766	EIF4E1B	99	80.328	ENSMLUG00000001437	EIF4E1B	85	87.143	Myotis_lucifugus
ENSG00000175766	EIF4E1B	100	97.778	ENSNLEG00000012532	EIF4E1B	100	97.107	Nomascus_leucogenys
ENSG00000175766	EIF4E1B	73	71.186	ENSMEUG00000002671	EIF4E1B	96	71.186	Notamacropus_eugenii
ENSG00000175766	EIF4E1B	57	92.806	ENSOPRG00000008875	EIF4E1B	93	92.806	Ochotona_princeps
ENSG00000175766	EIF4E1B	97	79.079	ENSODEG00000009390	EIF4E1B	99	79.079	Octodon_degus
ENSG00000175766	EIF4E1B	76	91.848	ENSOCUG00000007864	EIF4E1B	87	89.175	Oryctolagus_cuniculus
ENSG00000175766	EIF4E1B	87	86.256	ENSOGAG00000005844	EIF4E1B	100	86.256	Otolemur_garnettii
ENSG00000175766	EIF4E1B	79	87.500	ENSOARG00000002979	EIF4E1B	83	87.500	Ovis_aries
ENSG00000175766	EIF4E1B	98	98.312	ENSPPAG00000036530	EIF4E1B	95	98.312	Pan_paniscus
ENSG00000175766	EIF4E1B	100	82.591	ENSPPRG00000011119	EIF4E1B	100	81.781	Panthera_pardus
ENSG00000175766	EIF4E1B	98	82.645	ENSPTIG00000012304	EIF4E1B	99	82.231	Panthera_tigris_altaica
ENSG00000175766	EIF4E1B	100	97.934	ENSPTRG00000028481	EIF4E1B	100	97.934	Pan_troglodytes
ENSG00000175766	EIF4E1B	100	91.870	ENSPANG00000014775	EIF4E1B	100	92.276	Papio_anubis
ENSG00000175766	EIF4E1B	75	72.928	ENSPKIG00000025064	eif4e1b	85	72.928	Paramormyrops_kingsleyae
ENSG00000175766	EIF4E1B	76	82.609	ENSPCIG00000018442	EIF4E1B	72	82.609	Phascolarctos_cinereus
ENSG00000175766	EIF4E1B	75	96.133	ENSPPYG00000016077	-	83	96.133	Pongo_abelii
ENSG00000175766	EIF4E1B	51	85.366	ENSPCAG00000003618	-	100	85.366	Procavia_capensis
ENSG00000175766	EIF4E1B	98	78.243	ENSPCOG00000019904	EIF4E1B	99	78.903	Propithecus_coquereli
ENSG00000175766	EIF4E1B	73	92.614	ENSPVAG00000017039	EIF4E1B	96	81.731	Pteropus_vampyrus
ENSG00000175766	EIF4E1B	75	73.481	ENSPNAG00000000195	eif4e1b	84	73.481	Pygocentrus_nattereri
ENSG00000175766	EIF4E1B	100	92.245	ENSRBIG00000039242	EIF4E1B	99	96.682	Rhinopithecus_bieti
ENSG00000175766	EIF4E1B	100	92.245	ENSRROG00000042084	EIF4E1B	100	93.469	Rhinopithecus_roxellana
ENSG00000175766	EIF4E1B	100	88.430	ENSSBOG00000030710	EIF4E1B	100	88.017	Saimiri_boliviensis_boliviensis
ENSG00000175766	EIF4E1B	76	82.703	ENSSHAG00000007864	EIF4E1B	93	82.703	Sarcophilus_harrisii
ENSG00000175766	EIF4E1B	81	69.744	ENSSFOG00015005488	eif4e1b	89	69.744	Scleropages_formosus
ENSG00000175766	EIF4E1B	54	79.348	ENSSARG00000010425	-	83	79.592	Sorex_araneus
ENSG00000175766	EIF4E1B	88	71.362	ENSSPUG00000006304	EIF4E1B	99	79.545	Sphenodon_punctatus
ENSG00000175766	EIF4E1B	98	78.601	ENSSSCG00000014052	EIF4E1B	99	78.189	Sus_scrofa
ENSG00000175766	EIF4E1B	69	80.723	ENSTGUG00000000504	EIF4E1B	99	80.723	Taeniopygia_guttata
ENSG00000175766	EIF4E1B	70	78.824	ENSTBEG00000001631	EIF4E1B	94	78.824	Tupaia_belangeri
ENSG00000175766	EIF4E1B	74	87.778	ENSTTRG00000014026	EIF4E1B	85	87.778	Tursiops_truncatus
ENSG00000175766	EIF4E1B	93	84.444	ENSUAMG00000022136	EIF4E1B	98	88.462	Ursus_americanus
ENSG00000175766	EIF4E1B	73	93.182	ENSVVUG00000001475	EIF4E1B	73	93.182	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000340	RNA 7-methylguanosine cap binding	21873635.	IBA	Function
GO:0003743	translation initiation factor activity	21873635.	IBA	Function
GO:0005845	mRNA cap binding complex	-	ISS	Component
GO:0006413	translational initiation	-	IEA	Process
GO:0006417	regulation of translation	-	IEA	Process
GO:0016281	eukaryotic translation initiation factor 4F complex	21873635.	IBA	Component

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.