EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
22438565	Gender influences the class III and V β-tubulin ability to predict poor outcome in colorectal cancer.	Clin Cancer Res	2012 May 15	Mariani M	doi: 10.1158/1078-0432.CCR-11-2318

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr18	12308793	Missense_Mutation	novel	S55L	0.5
BLCA	chr18	12326038	Missense_Mutation	NA	D417N	0.04
BLCA	chr18	12325477	Frame_Shift_Ins	novel	*A231Dfs20**	0.41
BLCA	chr18	12308770	Silent	novel	I47I	0.1
BLCA	chr18	12325109	Missense_Mutation	novel	T107R	0.79
BLCA	chr18	12308762	Missense_Mutation	NA	E45K	0.18
BLCA	chr18	12325599	Silent	rs776288663	F270F	0.38
BLCA	chr18	12325867	Missense_Mutation	NA	G360S	0.14
BLCA	chr18	12308767	Frame_Shift_Del	novel	*I47Tfs21**	0.09
BLCA	chr18	12325381	Missense_Mutation	novel	E198K	0.42
BLCA	chr18	12329793	3'Flank	novel		0.23
BRCA	chr18	12325961	Missense_Mutation	rs763504507	R391H	0.15
BRCA	chr18	12326153	3'UTR	novel		0.34
CESC	chr18	12325260	Silent	rs758140585	E157E	0.16
CESC	chr18	12325245	Silent	novel	I152I	0.25
CESC	chr18	12308749	Silent	novel	S40S	0.36
CESC	chr18	12325218	Silent	rs753362806	T143T	0.34
CESC	chr18	12329155	3'Flank	novel		0.25
COAD	chr18	12325519	Missense_Mutation	NA	G244C	0.35
COAD	chr18	12325540	Missense_Mutation	rs756545880	R251C	0.26
COAD	chr18	12325563	Silent	novel	V258V	0.25
COAD	chr18	12325724	Missense_Mutation	NA	T312I	0.33
COAD	chr18	12325602	Silent	rs575654137	A271A	0.3
COAD	chr18	12325770	Silent	rs758456776	D327D	0.22
COAD	chr18	12325207	Missense_Mutation	novel	G140R	0.25
COAD	chr18	12325879	Missense_Mutation	novel	A364T	0.06
COAD	chr18	12325116	Silent	novel	G109G	0.15
ESCA	chr18	12325139	Missense_Mutation	novel	L117R	0.25
ESCA	chr18	12325140	Silent	novel	L117L	0.25
ESCA	chr18	12310964	Missense_Mutation	novel	A63V	0.67
ESCA	chr18	12310965	Silent	rs34553814	A63A	0.65
GBM	chr18	12325906	Missense_Mutation	novel	A373P	0.23
GBM	chr18	12308685	Splice_Site	novel	X20_splice	0.12
GBM	chr18	12308646	Intron	novel		0.42
GBM	chr18	12310965	Silent	rs34553814	A63A	0.51
GBM	chr18	12325236	Silent	rs754393310	T149T	0.54
GBM	chr18	12325759	Nonsense_Mutation	novel	K324*	0.43
GBM	chr18	12308773	Silent	rs760234318	N48N	0.18
GBM	chr18	12325796	Missense_Mutation	novel	K336R	0.1
HNSC	chr18	12311046	Silent	novel	F90F	0.31
HNSC	chr18	12325644	Silent	novel	T285T	0.26
HNSC	chr18	12310987	Missense_Mutation	novel	G71S	0.07
HNSC	chr18	12325304	Missense_Mutation	novel	S172L	0.5
HNSC	chr18	12325402	Missense_Mutation	rs746302836	E205K	0.15
KIRC	chr18	12324970	Intron	novel		0.2
LGG	chr18	12311034	Silent	novel	R86R	0.22
LGG	chr18	12325232	Missense_Mutation	novel	G148D	0.08
LGG	chr18	12325590	Missense_Mutation	novel	M267I	0.39
LIHC	chr18	12325367	Missense_Mutation	NA	V193E	0.82
LIHC	chr18	12310994	Missense_Mutation	novel	M73K	0.45
LIHC	chr18	12308600	Intron	novel		0.26
LUAD	chr18	12329795	3'Flank	novel		0.11
LUAD	chr18	12326018	Missense_Mutation	novel	E410A	0.04
LUAD	chr18	12325225	Missense_Mutation	novel	G146C	0.08
LUAD	chr18	12325518	Silent	rs756946980	P243P	0.15
LUAD	chr18	12325390	Missense_Mutation	novel	C201S	0.05
LUAD	chr18	12326120	In_Frame_Ins	novel	I444delinsMR	0.07
LUAD	chr18	12325203	Silent	NA	S138S	0.36
LUSC	chr18	12325410	Silent	rs780101902	L207L	0.2
LUSC	chr18	12308714	Missense_Mutation	novel	G29R	0.61
LUSC	chr18	12325510	Missense_Mutation	novel	R241C	0.58
LUSC	chr18	12325246	Missense_Mutation	novel	S153C	0.36
LUSC	chr18	12325638	Silent	NA	A283A	0.22
LUSC	chr18	12311001	Silent	NA	S75S	0.26
LUSC	chr18	12325623	Missense_Mutation	novel	S278R	0.08
MESO	chr18	12325866	Silent	rs200462932	R359R	0.69
OV	chr18	12308668	Intron	novel		0.24
PAAD	chr18	12325895	Missense_Mutation	novel	G369D	0.19
PRAD	chr18	12325162	Missense_Mutation	NA	E125K	0.24
READ	chr18	12325983	Missense_Mutation	novel	F398L	0.17
READ	chr18	12326121	Silent	rs376872570	I444I	0.15
SKCM	chr18	12326117	Missense_Mutation	novel	E443A	0.07
SKCM	chr18	12325672	Missense_Mutation	NA	D295N	0.2
SKCM	chr18	12325867	Missense_Mutation	NA	G360S	0.39
SKCM	chr18	12325643	Missense_Mutation	novel	T285I	0.81
SKCM	chr18	12325644	Silent	rs200435931	T285T	0.84
SKCM	chr18	12325741	Missense_Mutation	NA	R318C	0.21
SKCM	chr18	12325657	Missense_Mutation	NA	T290A	0.28
SKCM	chr18	12325113	Silent	NA	E108E	0.53
SKCM	chr18	12325369	Nonsense_Mutation	NA	E194*	0.31
SKCM	chr18	12325202	Missense_Mutation	NA	S138L	0.31
SKCM	chr18	12325478	Missense_Mutation	novel	S230F	0.55
SKCM	chr18	12325479	Silent	novel	S230S	0.56
SKCM	chr18	12325307	Missense_Mutation	NA	P173L	0.35
SKCM	chr18	12324999	Intron	novel		0.31
STAD	chr18	12325617	Silent	rs376782121	R276R	0.48
STAD	chr18	12308307	Silent	novel	V5V	0.25
STAD	chr18	12325605	Silent	rs140883153	P272P	0.24
STAD	chr18	12325852	Missense_Mutation	rs751476032	D355N	0.2
STAD	chr18	12325591	Missense_Mutation	NA	P268S	0.13
STAD	chr18	12325460	Missense_Mutation	NA	D224V	0.3
STAD	chr18	12325490	Missense_Mutation	novel	S234T	0.46
STAD	chr18	12325151	Missense_Mutation	rs368245437	R121Q	0.34
STAD	chr18	12325750	Missense_Mutation	novel	M321V	0.28
STAD	chr18	12311001	Silent	NA	S75S	0.42
STAD	chr18	12326167	3'UTR	rs745437289		0.4
STAD	chr18	12326001	Silent	NA	D404D	0.24
STAD	chr18	12325561	Missense_Mutation	NA	V258M	0.16
STAD	chr18	12325878	Missense_Mutation	novel	M363I	0.05
STAD	chr18	12311006	Missense_Mutation	rs571214765	R77Q	0.5
STAD	chr18	12325336	Missense_Mutation	novel	Y183H	0.4
STAD	chr18	12325184	Missense_Mutation	NA	G132D	0.15
THYM	chr18	12308716	Silent	rs376972319	G29G	0.12
UCEC	chr18	12325599	Silent	rs776288663	F270F	0.27
UCEC	chr18	12326349	3'UTR	novel		0.45
UCEC	chr18	12326487	3'UTR	novel		0.41
UCEC	chr18	12325381	Missense_Mutation	novel	E198K	0.41
UCEC	chr18	12308759	Missense_Mutation	novel	L44M	0.26
UCEC	chr18	12325880	Missense_Mutation	novel	A364V	0.38
UCEC	chr18	12325293	Silent	rs777054234	S168S	0.22
UCEC	chr18	12325591	Missense_Mutation	NA	P268S	0.42
UCEC	chr18	12325506	Silent	rs763720238	S239S	0.23
UCEC	chr18	12325671	Silent	rs778849487	F294F	0.11
UCEC	chr18	12325693	Missense_Mutation	NA	A302T	0.39
UCEC	chr18	12310984	Missense_Mutation	novel	P70S	0.2
UCEC	chr18	12325524	Silent	novel	Q245Q	0.3
UCEC	chr18	12325558	Missense_Mutation	novel	M257V	0.42
UCEC	chr18	12325200	Missense_Mutation	novel	H137Q	0.33
UCEC	chr18	12325735	Missense_Mutation	novel	V316M	0.33
UCEC	chr18	12325986	Silent	novel	T399T	0.39
UCEC	chr18	12324895	Intron	novel		0.25
UCEC	chr18	12308708	Nonsense_Mutation	novel	E27*	0.38
UCEC	chr18	12325904	Missense_Mutation	novel	T372M	0.58
UCEC	chr18	12325603	Missense_Mutation	novel	P272S	0.44
UCEC	chr18	12325352	Missense_Mutation	NA	S188L	0.41
UCEC	chr18	12325676	Missense_Mutation	NA	A296V	0.29
UCEC	chr18	12308704	Silent	novel	S25S	0.32
UCEC	chr18	12325446	Silent	novel	T219T	0.29
UCEC	chr18	12326460	3'UTR	novel		0.36
UCEC	chr18	12324877	Intron	novel		0.67
UCEC	chr18	12325410	Silent	novel	L207L	0.33
UCEC	chr18	12326085	Silent	NA	D432D	0.28
UCEC	chr18	12326038	Missense_Mutation	NA	D417N	0.25
UCEC	chr18	12325400	Missense_Mutation	novel	N204S	0.11
UCEC	chr18	12325704	Silent	rs145635323	P305P	0.42
UCEC	chr18	12325317	Silent	rs775559623	S176S	0.4
UCEC	chr18	12310947	Missense_Mutation	novel	Q57H	0.09
UCEC	chr18	12311007	Silent	novel	R77R	0.55
UCEC	chr18	12325605	Silent	rs140883153	P272P	0.11
UCEC	chr18	12325698	Silent	novel	C303C	0.27
UCEC	chr18	12325779	Missense_Mutation	rs777748559	M330I	0.17
UCEC	chr18	12325511	Missense_Mutation	novel	R241H	0.48
UCEC	chr18	12326116	Missense_Mutation	novel	E443K	0.26
UCEC	chr18	12326489	3'UTR	novel		0.34

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LAML	DEL	0.0419	0.020884

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
STAD	0.015	Kaplan-Meier Survival Analysis
MESO	0.00049	Kaplan-Meier Survival Analysis
ACC	0.00011	Kaplan-Meier Survival Analysis
HNSC	0.023	Kaplan-Meier Survival Analysis
SKCM	0.0036	Kaplan-Meier Survival Analysis
COAD	0.0096	Kaplan-Meier Survival Analysis
BLCA	0.00012	Kaplan-Meier Survival Analysis
CESC	0.0079	Kaplan-Meier Survival Analysis
LAML	0.026	Kaplan-Meier Survival Analysis
UCEC	0.014	Kaplan-Meier Survival Analysis
LUAD	0.024	Kaplan-Meier Survival Analysis
UVM	0.0028	Kaplan-Meier Survival Analysis
OV	0.033	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000176014 (Gene tree)
Gene ID: 84617
Gene Symbol: TUBB6
Alias: MGC4083|HsT1601
Full Name: tubulin beta 6 class V
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 36,652 bases
Position: chr18:12,307,669-12,344,320
Accession: 20776
RBP type: non-canonical RBP
Summary: (Tubulin Beta 6 Class V) is a Protein Coding gene. Diseases associated with TUBB6 include Facial Palsy, Congenital, With Ptosis And Velopharyngeal Dysfunction and Tubulin, Beta. Among its related pathways are Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding and Regulation of CFTR activity (norm and CF). Gene Ontology (GO) annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBB3.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000591208	TUBB6-211	1492	-	ENSP00000466849	136 (aa)	-	K7EN98
ENST00000591909	TUBB6-213	1017	-	ENSP00000465040	104 (aa)	-	K7EJ64
ENST00000587204	TUBB6-206	408	-	-	- (aa)	-	-
ENST00000590967	TUBB6-210	430	-	ENSP00000465386	115 (aa)	-	K7EJZ4
ENST00000592683	TUBB6-214	481	-	ENSP00000467969	104 (aa)	-	K7EQT3
ENST00000586653	TUBB6-203	788	-	ENSP00000468820	96 (aa)	-	K7ESQ3
ENST00000590693	TUBB6-209	524	-	ENSP00000465891	130 (aa)	-	K7EL29
ENST00000586691	TUBB6-204	359	-	ENSP00000465448	31 (aa)	-	K7EK43
ENST00000590103	TUBB6-207	1075	-	ENSP00000468777	338 (aa)	-	K7ESM5
ENST00000591463	TUBB6-212	485	-	ENSP00000468571	116 (aa)	-	K7ES63
ENST00000317702	TUBB6-201	2064	-	ENSP00000318697	446 (aa)	-	Q9BUF5
ENST00000586810	TUBB6-205	1493	-	ENSP00000467348	141 (aa)	-	K7EPE5
ENST00000590388	TUBB6-208	576	-	ENSP00000468179	110 (aa)	-	K7ERA8
ENST00000417736	TUBB6-202	2163	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000176014's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04145	Phagosome	KEGG
hsa04540	Gap junction	KEGG
hsa05130	Pathogenic Escherichia coli infection	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000176014's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000226	microtubule cytoskeleton organization	21873635.	IBA	Process
GO:0000278	mitotic cell cycle	21873635.	IBA	Process
GO:0003674	molecular_function	-	ND	Function
GO:0003924	GTPase activity	-	IEA	Function
GO:0005200	structural constituent of cytoskeleton	21873635.	IBA	Function
GO:0005525	GTP binding	21873635.	IBA	Function
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005874	microtubule	21873635.	IBA	Component
GO:0005874	microtubule	21525035.	IDA	Component
GO:0007017	microtubule-based process	21873635.	IBA	Process
GO:0070062	extracellular exosome	19056867.23533145.	HDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.