EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr19	2434858	Missense_Mutation	rs567796688	R304H	0.25
BLCA	chr19	2438449	Missense_Mutation	novel	E162K	0.47
BLCA	chr19	2433864	Missense_Mutation	novel	E482Q	0.29
BLCA	chr19	2438518	Missense_Mutation	NA	E139K	0.64
BLCA	chr19	2434299	Missense_Mutation	novel	E400Q	0.14
BLCA	chr19	2438184	Missense_Mutation	novel	F221L	0.4
BLCA	chr19	2430874	3'UTR	novel		0.17
BLCA	chr19	2432501	Missense_Mutation	novel	R502K	0.24
BLCA	chr19	2434503	Nonsense_Mutation	novel	E332*	0.24
BLCA	chr19	2430919	Missense_Mutation	rs748688330	V619M	0.38
BRCA	chr19	2434064	Nonsense_Mutation	novel	S415*	0.11
BRCA	chr19	2431813	Silent	NA	F560F	0.67
BRCA	chr19	2434444	Missense_Mutation	NA	K351N	0.21
BRCA	chr19	2430866	3'UTR	rs764444575		0.24
BRCA	chr19	2434315	Silent	NA	L394L	0.11
CESC	chr19	2430828	3'UTR	novel		0.25
CESC	chr19	2430814	3'UTR	novel		0.55
CESC	chr19	2430828	3'UTR	novel		0.17
CESC	chr19	2434315	Silent	NA	L394L	0.3
COAD	chr19	2430803	3'UTR	novel		0.12
COAD	chr19	2435056	Missense_Mutation	NA	H267R	0.47
COAD	chr19	2434020	Missense_Mutation	rs367908162	R430C	0.31
COAD	chr19	2430849	3'UTR	novel		0.29
COAD	chr19	2433931	Silent	rs749342900	S459S	0.54
COAD	chr19	2430722	3'UTR	novel		0.33
COAD	chr19	2456700	Silent	novel	I78I	0.19
COAD	chr19	2431863	Frame_Shift_Ins	rs776267567	*S544Lfs23**	0.45
COAD	chr19	2438216	Missense_Mutation	novel	R211C	0.08
COAD	chr19	2430929	In_Frame_Del	NA	R615del	0.04
ESCA	chr19	2432417	Missense_Mutation	rs771054060	T530M	0.73
ESCA	chr19	2431822	Silent	novel	G557G	0.15
ESCA	chr19	2434297	Missense_Mutation	rs764433406	E400D	0.45
ESCA	chr19	2434832	Missense_Mutation	novel	R313C	0.46
ESCA	chr19	2434895	Missense_Mutation	novel	S292R	0.29
GBM	chr19	2434330	Silent	NA	N389N	0.09
HNSC	chr19	2435011	Missense_Mutation	novel	Y282C	0.25
HNSC	chr19	2438425	Missense_Mutation	novel	K170E	0.37
HNSC	chr19	2435056	Missense_Mutation	NA	H267R	0.21
HNSC	chr19	2431829	Missense_Mutation	novel	G555V	0.27
HNSC	chr19	2434811	Nonsense_Mutation	novel	Q320*	0.35
HNSC	chr19	2432470	Missense_Mutation	novel	E512D	0.28
HNSC	chr19	2444433	Silent	novel	L124L	0.13
HNSC	chr19	2434448	Missense_Mutation	rs754644849	R350Q	0.07
HNSC	chr19	2438472	Missense_Mutation	novel	S154F	0.32
KIRC	chr19	2444469	Silent	NA	R112R	0.17
LGG	chr19	2433896	Missense_Mutation	rs761548544	S471L	0.24
LIHC	chr19	2435011	Missense_Mutation	NA	Y282F	0.33
LUAD	chr19	2444468	Missense_Mutation	NA	E113Q	0.11
LUAD	chr19	2432469	Missense_Mutation	novel	I513F	0.15
LUAD	chr19	2438279	Missense_Mutation	NA	G190C	0.55
LUAD	chr19	2438279	Missense_Mutation	NA	G190C	0.38
LUAD	chr19	2444433	Silent	novel	L124L	0.38
LUAD	chr19	2438391	Missense_Mutation	novel	R181L	0.69
LUAD	chr19	2438520	Missense_Mutation	novel	R138M	0.32
LUAD	chr19	2438181	Silent	rs376727524	R222R	0.14
LUAD	chr19	2434015	Silent	NA	L431L	0.64
LUSC	chr19	2431580	Missense_Mutation	rs777988017	E597K	0.13
LUSC	chr19	2432444	Missense_Mutation	novel	Y521C	0.33
LUSC	chr19	2433847	Missense_Mutation	novel	Q487H	0.26
LUSC	chr19	2431799	Missense_Mutation	novel	V565D	0.09
LUSC	chr19	2456783	Missense_Mutation	novel	R51C	0.41
LUSC	chr19	2431555	Missense_Mutation	novel	H605P	0.14
OV	chr19	2431655	Missense_Mutation	novel	V572L	0.26
OV	chr19	2431834	Frame_Shift_Del	novel	*S553Mfs13**	0.4
OV	chr19	2432482	Silent	NA	L508L	0.29
PAAD	chr19	2435156	Missense_Mutation	rs148936043	R234W	0.14
PRAD	chr19	2434014	Missense_Mutation	rs759061408	G432S	0.46
PRAD	chr19	2434508	Missense_Mutation	novel	A330V	0.42
READ	chr19	2430854	3'UTR	novel		0.13
READ	chr19	2438531	Splice_Region	rs148213507	S134S	0.44
READ	chr19	2432466	Missense_Mutation	rs777408921	A514T	0.2
SARC	chr19	2434402	Silent	NA	D365D	0.52
SKCM	chr19	2456694	Silent	NA	E80E	0.17
SKCM	chr19	2433867	Silent	NA	L481L	0.06
SKCM	chr19	2438261	Missense_Mutation	NA	K196E	0.08
SKCM	chr19	2433977	Missense_Mutation	NA	P444L	0.18
SKCM	chr19	2431608	Silent	rs750127556	E587E	0.16
SKCM	chr19	2433921	Missense_Mutation	NA	H463Y	0.1
SKCM	chr19	2434475	Missense_Mutation	NA	A341V	0.44
SKCM	chr19	2434054	Silent	novel	T418T	0.3
SKCM	chr19	2438169	Silent	rs182026397	F226F	0.15
STAD	chr19	2431864	Frame_Shift_Del	NA	*S544Rfs31**	0.27
STAD	chr19	2431602	Silent	NA	G589G	0.21
STAD	chr19	2433913	Silent	rs754958278	A465A	0.15
STAD	chr19	2435065	Missense_Mutation	NA	R264Q	0.13
STAD	chr19	2435144	Missense_Mutation	rs773444127	E238K	0.44
STAD	chr19	2433834	Missense_Mutation	NA	S492P	0.25
STAD	chr19	2433836	Missense_Mutation	NA	N491S	0.05
STAD	chr19	2433845	Missense_Mutation	NA	L488P	0.19
STAD	chr19	2434863	Silent	rs144417417	A302A	0.45
UCEC	chr19	2444470	Missense_Mutation	rs367966814	R112Q	0.44
UCEC	chr19	2431859	Missense_Mutation	rs746479856	T545M	0.22
UCEC	chr19	2438260	Missense_Mutation	novel	K196T	0.18
UCEC	chr19	2444503	Missense_Mutation	NA	A101V	0.15
UCEC	chr19	2433895	Silent	rs776051907	S471S	0.15
UCEC	chr19	2433888	Missense_Mutation	rs771415464	V474I	0.44
UCEC	chr19	2431785	Missense_Mutation	rs149924406	E570K	0.5
UCEC	chr19	2438216	Missense_Mutation	novel	R211C	0.57
UCEC	chr19	2438513	Silent	rs751439345	G140G	0.27
UCEC	chr19	2431619	Missense_Mutation	rs201873197	R584C	0.35
UCEC	chr19	2431861	Silent	rs147703402	S544S	0.41
UCEC	chr19	2438169	Silent	rs182026397	F226F	0.48
UCEC	chr19	2430947	Silent	novel	D609D	0.33
UCEC	chr19	2434068	Missense_Mutation	rs771541316	V414I	0.39
UCEC	chr19	2431804	Silent	NA	V563V	0.31
UCEC	chr19	2438455	Missense_Mutation	rs199671950	E160K	0.21
UCEC	chr19	2434874	Missense_Mutation	novel	A299T	0.77
UCEC	chr19	2432437	Silent	rs375419899	L523L	0.34
UCEC	chr19	2431619	Missense_Mutation	rs201873197	R584C	0.27
UCEC	chr19	2434329	Missense_Mutation	novel	A390T	0.32
UCEC	chr19	2434033	Silent	novel	L425L	0.33

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	DEL	0.0556	0.058467
LIHC	DEL	0.1865	4.7028e-08
PAAD	DEL	0.1467	0.0060878
READ	DEL	0.1333	0.23023
THCA	DEL	0.014	0.10598
UCS	DEL	0.7679	8.0449e-14

Survival Analysis

Cancer	P-value	Q-value
THYM	0.013	Kaplan-Meier Survival Analysis
KIRC	0.00026	Kaplan-Meier Survival Analysis
STAD	0.00027	Kaplan-Meier Survival Analysis
SARC	0.00011	Kaplan-Meier Survival Analysis
SKCM	0.00014	Kaplan-Meier Survival Analysis
PRAD	0.0025	Kaplan-Meier Survival Analysis
LUSC	0.016	Kaplan-Meier Survival Analysis
ESCA	0.019	Kaplan-Meier Survival Analysis
KIRP	0.00072	Kaplan-Meier Survival Analysis
PAAD	0.0095	Kaplan-Meier Survival Analysis
BLCA	0.047	Kaplan-Meier Survival Analysis
READ	0.031	Kaplan-Meier Survival Analysis
LAML	0.0047	Kaplan-Meier Survival Analysis
LIHC	0.00012	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis
LUAD	0.0001	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000176619 (Gene tree)
Gene ID: 84823
Gene Symbol: LMNB2
Alias: LMN2
Full Name: lamin B2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 29,359 bases
Position: chr19:2,427,638-2,456,996
Accession: 6638
RBP type: non-canonical RBP
Summary: This gene encodes a B type nuclear lamin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Mutations in this gene are associated with acquired partial lipodystrophy. [provided by RefSeq, May 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
11168378	Identification of tyrosine-phosphorylated proteins associated with the nuclear envelope.	Eur J Biochem	2001 Jan	Otto H	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000534495	LMNB2-206	491	-	-	- (aa)	-	-
ENST00000475819	LMNB2-202	885	-	-	- (aa)	-	-
ENST00000490554	LMNB2-203	689	-	-	- (aa)	-	-
ENST00000325327	LMNB2-201	4671	-	ENSP00000327054	620 (aa)	-	Q03252
ENST00000532465	LMNB2-205	769	-	-	- (aa)	-	-
ENST00000527409	LMNB2-204	838	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000176619's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04210	Apoptosis	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000176619's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000176619	LMNB2	100	81.511	ENSMUSG00000062075	Lmnb2	99	83.445	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003674	molecular_function	-	ND	Function
GO:0005198	structural molecule activity	-	IEA	Function
GO:0005515	protein binding	26524528.29568061.30021884.	IPI	Function
GO:0005637	nuclear inner membrane	-	IEA	Component
GO:0005638	lamin filament	-	IEA	Component
GO:0008150	biological_process	-	ND	Process
GO:0031965	nuclear membrane	-	IDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.