EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr11	763429	Missense_Mutation	novel	V183M	0.27
BLCA	chr11	760339	Intron	novel		0.5
BLCA	chr11	763392	Silent	NA	F170F	0.34
BLCA	chr11	763910	Silent	rs142263629	N267N	0.18
BLCA	chr11	764872	3'UTR	novel		0.16
BLCA	chr11	760284	Intron	novel		0.18
BLCA	chr11	763933	Missense_Mutation	novel	S275L	0.31
BLCA	chr11	760226	Missense_Mutation	rs752130789	S145L	0.5
BLCA	chr11	763868	Silent	NA	L253L	0.83
BLCA	chr11	764330	Missense_Mutation	novel	S293C	0.34
BLCA	chr11	764430	Silent	novel	L326L	0.65
BRCA	chr11	763392	In_Frame_Del	rs760405582	S171del	0.33
COAD	chr11	764308	Missense_Mutation	NA	K286Q	0.32
COAD	chr11	763910	Silent	rs142263629	N267N	0.26
COAD	chr11	760142	Missense_Mutation	rs764703431	A117V	0.07
COAD	chr11	763367	Missense_Mutation	NA	I162T	0.41
COAD	chr11	763825	Missense_Mutation	rs773023043	R239H	0.19
COAD	chr11	763381	Missense_Mutation	NA	T167A	0.2
GBM	chr11	764298	Missense_Mutation	novel	S282R	0.31
HNSC	chr11	747535	Silent	novel	L18L	0.35
HNSC	chr11	763351	Missense_Mutation	rs140952110	E157K	0.18
HNSC	chr11	764345	In_Frame_Del	rs756350214	N299del	0.27
KIRC	chr11	763505	Missense_Mutation	NA	P208H	0.26
KIRP	chr11	747455	5'UTR	novel		0.48
LGG	chr11	755990	Missense_Mutation	rs772888456	R70Q	0.13
LGG	chr11	755902	Missense_Mutation	novel	D41N	0.14
LUAD	chr11	764846	3'UTR	rs145192861		0.11
LUSC	chr11	763486	Missense_Mutation	rs140985565	D202N	0.26
LUSC	chr11	760170	Silent	rs553335941	I126I	0.21
LUSC	chr11	760201	Missense_Mutation	novel	D137H	0.08
OV	chr11	760215	Missense_Mutation	novel	I141M	0.24
OV	chr11	764843	Frame_Shift_Ins	novel	*338W	0.13
OV	chr11	760216	Missense_Mutation	novel	K142E	0.18
OV	chr11	758949	Splice_Site	novel	X74_splice	0.46
OV	chr11	760252	Missense_Mutation	novel	K154Q	0.12
PRAD	chr11	747468	5'UTR	novel		0.44
PRAD	chr11	764952	3'UTR	novel		0.33
READ	chr11	759027	Missense_Mutation	rs778205812	P100L	0.09
READ	chr11	760261	Splice_Region	novel		0.15
SARC	chr11	763851	Missense_Mutation	novel	A248S	0.1
SKCM	chr11	764378	Missense_Mutation	NA	S309F	0.21
SKCM	chr11	763394	Missense_Mutation	novel	S171F	0.44
SKCM	chr11	764334	Silent	NA	F294F	0.44
SKCM	chr11	758967	Missense_Mutation	NA	I80N	0.43
SKCM	chr11	747521	Frame_Shift_Del	novel	*A14Rfs35**	0.38
STAD	chr11	763457	Missense_Mutation	rs151052416	R192H	0.23
STAD	chr11	755877	Splice_Site	novel	X33_splice	0.24
STAD	chr11	755935	Missense_Mutation	NA	A52T	0.14
STAD	chr11	760320	Intron	novel		0.12
STAD	chr11	764817	Missense_Mutation	rs772647470	R329Q	0.2
STAD	chr11	760142	Missense_Mutation	rs764703431	A117V	0.1
STAD	chr11	764872	3'UTR	novel		0.12
STAD	chr11	764878	3'UTR	rs375388046		0.4
STAD	chr11	759008	Nonsense_Mutation	NA	E94*	0.23
STAD	chr11	764847	3'UTR	rs148726202		0.11
THCA	chr11	764366	Missense_Mutation	novel	V305E	0.06
THCA	chr11	764367	Silent	novel	V305V	0.06
UCEC	chr11	755887	Missense_Mutation	rs561919659	E36K	0.24
UCEC	chr11	764325	Missense_Mutation	NA	E291D	0.16
UCEC	chr11	764833	Missense_Mutation	NA	E334D	0.27
UCEC	chr11	763825	Missense_Mutation	rs773023043	R239H	0.5
UCEC	chr11	764294	Missense_Mutation	novel	A281V	0.61
UCEC	chr11	763799	Missense_Mutation	novel	K230N	0.56
UCEC	chr11	760171	Missense_Mutation	novel	E127K	0.44
UCEC	chr11	756000	Splice_Region	novel	G73G	0.42
UCEC	chr11	764833	Missense_Mutation	NA	E334D	0.21
UCEC	chr11	763420	Missense_Mutation	rs773580366	E180K	0.24
UCEC	chr11	763825	Missense_Mutation	rs773023043	R239H	0.51
UCEC	chr11	760486	Intron	novel		0.44
UCEC	chr11	763440	Silent	novel	I186I	0.47
UCEC	chr11	760288	Intron	novel		0.22
UCEC	chr11	764301	Silent	rs550990914	D283D	0.33
UCEC	chr11	759032	Nonsense_Mutation	rs202135397	R102*	0.3
UCEC	chr11	759053	Missense_Mutation	NA	A109T	0.4
UCEC	chr11	764349	Silent	rs142741895	N299N	0.42
UCEC	chr11	763836	Missense_Mutation	novel	E243K	0.2
UCEC	chr11	758985	Missense_Mutation	novel	K86T	0.43
UCEC	chr11	759053	Missense_Mutation	NA	A109T	0.19

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.2949	0.02701
ESCA	AMP	0.1413	0.018342
ESCA	DEL	0.337	0.0016785
GBM	DEL	0.182	0.0048476
HNSC	DEL	0.2433	0.00051729
LUAD	DEL	0.1899	0.00044751
LUSC	DEL	0.3892	4.3974e-14
OV	DEL	0.5648	4.8003e-42
PAAD	DEL	0.1087	0.022808
PCPG	AMP	0.0309	0.23196
PCPG	DEL	0.3272	0.00064285
TGCT	DEL	0.56	0.21504
UCEC	DEL	0.1763	2.4803e-07

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0029	Kaplan-Meier Survival Analysis
MESO	0.05	Kaplan-Meier Survival Analysis
KIRP	0.037	Kaplan-Meier Survival Analysis
PAAD	0.01	Kaplan-Meier Survival Analysis
PCPG	0.021	Kaplan-Meier Survival Analysis
BLCA	0.012	Kaplan-Meier Survival Analysis
CESC	0.038	Kaplan-Meier Survival Analysis
LAML	0.0024	Kaplan-Meier Survival Analysis
UCEC	0.044	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000177156 (Gene tree)
Gene ID: 6888
Gene Symbol: TALDO1
Alias: N
Full Name: transaldolase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 17,696 bases
Position: chr11:747,329-765,024
Accession: 11559
RBP type: non-canonical RBP
Summary: Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000533796	TALDO1-209	503	-	-	- (aa)	-	-
ENST00000532685	TALDO1-208	568	-	-	- (aa)	-	-
ENST00000530666	TALDO1-206	587	-	-	- (aa)	-	-
ENST00000528097	TALDO1-203	1231	-	ENSP00000437098	318 (aa)	-	F2Z393
ENST00000530440	TALDO1-205	710	-	ENSP00000433501	93 (aa)	-	E9PKI8
ENST00000319006	TALDO1-201	1346	-	ENSP00000321259	337 (aa)	-	P37837
ENST00000530119	TALDO1-204	1191	-	-	- (aa)	-	-
ENST00000528070	TALDO1-202	856	-	ENSP00000435042	50 (aa)	-	E9PM01
ENST00000532202	TALDO1-207	270	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000177156's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00030	Pentose phosphate pathway	KEGG
hsa01100	Metabolic pathways	KEGG
hsa01200	Carbon metabolism	KEGG
hsa01230	Biosynthesis of amino acids	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000177156	Proteinuria	9E-6	26420894
ENSG00000177156	Renal Insufficiency, Chronic	9E-6	26420894

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000177156's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000177156	TALDO1	98	58.982	YLR354C		99	58.982	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004801	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity	21873635.	IBA	Function
GO:0005515	protein binding	21044950.25854864.	IPI	Function
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005634	nucleus	-	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	16130169.	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005975	carbohydrate metabolic process	9524206.	TAS	Process
GO:0005999	xylulose biosynthetic process	-	TAS	Process
GO:0006002	fructose 6-phosphate metabolic process	-	IEA	Process
GO:0006098	pentose-phosphate shunt	-	TAS	Process
GO:0009052	pentose-phosphate shunt, non-oxidative branch	21873635.	IBA	Process
GO:0035722	interleukin-12-mediated signaling pathway	-	TAS	Process
GO:0048029	monosaccharide binding	-	IEA	Function
GO:0070062	extracellular exosome	20458337.23533145.	HDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.