EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
28079894MiR-26 enhances chemosensitivity and promotes apoptosis of hepatocellular carcinoma cells through inhibiting autophagy.Cell Death Dis2017 Jan 12Jin Fdoi: 10.1038/cddis.2016.461.
27687210Lack of mitochondrial DNA impairs chemical hypoxia-induced autophagy in liver tumor cells through ROS-AMPK-ULK1 signaling dysregulation independently of HIF-1α.Free Radic Biol Med2016 DecMarin JJGdoi: 10.1016/j.freeradbiomed.2016.09.025
28639909Silencing of NRAGE induces autophagy via AMPK/Ulk1/Atg13 signaling pathway in NSCLC cells.Tumour Biol2017 JunZhou Ydoi: 10.1177/1010428317709676.
28410240Ulk1 over-expression in human gastric cancer is correlated with patients' T classification and cancer relapse.Oncotarget2017 May 16Chen MBdoi: 10.18632/oncotarget.16734.
24955726Silencing of EEF2K (eukaryotic elongation factor-2 kinase) reveals AMPK-ULK1-dependent autophagy in colon cancer cells.Autophagy2014 SepXie CMdoi: 10.4161/auto.29164
22585231Low expression of ULK1 is associated with operable breast cancer progression and is an adverse prognostic marker of survival for patients.Breast Cancer Res Treat2012 JulTang Jdoi: 10.1007/s10549-012-2080-y
27679555Elevated levels of autophagy-related marker ULK1 and mitochondrion-associated autophagy inhibitor LRPPRC are associated with biochemical progression and overall survival after androgen deprivation therapy in patients with metastatic prostate cancer.J Clin Pathol2017 MayZhang HYdoi: 10.1136/jclinpath-2016-203926
28073914Serine/Threonine Kinase Unc-51-like Kinase-1 (Ulk1) Phosphorylates the Co-chaperone Cell Division Cycle Protein 37 (Cdc37) and Thereby Disrupts the Stability of Cdc37 Client Proteins.J Biol Chem2017 Feb 17Li Rdoi: 10.1074/jbc.M116.762443
28498429SBI0206965, a novel inhibitor of Ulk1, suppresses non-small cell lung cancer cell growth by modulating both autophagy and apoptosis pathways.Oncol Rep2017 JunTang Fdoi: 10.3892/or.2017.5635
27864418AMPK-ULK1-Mediated Autophagy Confers Resistance to BET Inhibitor JQ1 in Acute Myeloid Leukemia Stem Cells.Clin Cancer Res2017 Jun 1Jang JEdoi: 10.1158/1078-0432.CCR-16-1903
28614291CLDN1 Increases Drug Resistance of Non-Small Cell Lung Cancer by Activating Autophagy via Up-Regulation of ULK1 Phosphorylation.Med Sci Monit2017 Jun 14Zhao Z-
29470986Silencing of LncRNA-HOTAIR decreases drug resistance of Non-Small Cell Lung Cancer cells by inactivating autophagy via suppressing the phosphorylation of ULK1.Biochem Biophys Res Commun2018 Mar 18Yang Ydoi: 10.1016/j.bbrc.2018.02.141
29091866Combination of ULK1 and LC3B improve prognosis assessment of hepatocellular carcinoma.Biomed Pharmacother2018 JanWu DHdoi: 10.1016/j.biopha.2017.10.025

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr12131916592Splice_SitenovelX691_splice0.59
BLCAchr12131895648SilentnovelL53L0.28
BLCAchr12131915228Missense_MutationnovelQ507E0.33
BLCAchr12131919274SilentnovelL858L0.63
BLCAchr12131920076SilentnovelL967L0.2
BLCAchr12131919305Missense_MutationNAE869K0.31
BLCAchr12131895788Silentrs371613349L70L0.13
BLCAchr12131919992SilentNAL939L0.15
BLCAchr12131895043Missense_MutationnovelF14L0.23
BLCAchr12131917536Missense_MutationnovelR770C0.36
BLCAchr12131921137Missense_Mutationrs749327954R1000H0.17
BLCAchr12131895002Translation_Start_SiteNAM1?0.36
BLCAchr12131895819Missense_MutationNAF81L0.11RIO1
BLCAchr12131908730Missense_MutationnovelI135V0.39RIO1
BRCAchr12131909215Missense_MutationNAL215P0.14
BRCAchr12131920055SilentnovelF960F0.46
BRCAchr12131911982Missense_MutationNAS330F0.28
CESCchr12131915912Missense_Mutationrs150697369S544C0.56
CESCchr12131915088Missense_MutationNAS460C0.39
CESCchr12131916153Frame_Shift_InsnovelT625Rfs*230.21
CESCchr12131916526Frame_Shift_InsnovelF670Dfs*1570.08
CESCchr12131916469Silentrs138492147G650G0.4
CESCchr12131916567Missense_MutationnovelE683G0.38
CESCchr121319226633'UTRnovel0.37
CESCchr12131916429Frame_Shift_InsnovelS638Ifs*650.04
COADchr12131916470Missense_Mutationrs565402146V651M0.2
COADchr121319227973'UTRnovel0.83
COADchr12131909834Splice_SitenovelX242_splice0.1
COADchr12131920084Missense_Mutationrs369823883R970H0.35
COADchr12131921120Silentrs371996516D994D0.38
COADchr12131917521Frame_Shift_DelNAQ767Rfs*570.45
COADchr12131916428Missense_MutationNAP637T0.39
COADchr12131917521Frame_Shift_DelNAQ767Rfs*570.31
COADchr12131895656Missense_MutationNAS56Y0.38RIO1
COADchr12131915998Frame_Shift_DelNAT575Rfs*720.43
COADchr12131908700Missense_MutationNAA125T0.43RIO1
COADchr12131908914SilentnovelA169A0.13
COADchr12131911990Missense_MutationnovelD333H0.1
COADchr12131910259Frame_Shift_DelNAH274Ifs*1090.26
COADchr12131918612SilentNAP814P0.65
COADchr12131909941Missense_MutationNAP250S0.38
COADchr12131919269Missense_Mutationrs773571100V857I0.43
COADchr12131908736Missense_MutationnovelR137C0.22RIO1
COADchr12131917016Silentrs140491730P712P0.36
COADchr12131913217Silentrs757968994A372A0.5
COADchr12131909931Missense_MutationnovelE246D0.21
COADchr12131921219Silentrs138011167I1027I0.27
COADchr12131919477Missense_Mutationrs770028247A897V0.32
COADchr12131921337Silentrs117577371A1043A0.42
COADchr12131910259Frame_Shift_DelNAH274Ifs*1090.33
COADchr12131916426Frame_Shift_DelNAS638Afs*90.32
COADchr12131908700Missense_MutationNAA125T0.19RIO1
COADchr12131919313Frame_Shift_DelNAG873Afs*180.22
COADchr12131919556Silentrs143340589A923A0.18
COADchr12131910290Missense_MutationnovelP282H0.29
ESCAchr12131911944Splice_RegionnovelS317S0.25
ESCAchr12131921167Missense_MutationnovelA1010V0.23
ESCAchr121319228903'UTRnovel0.35
GBMchr12131895084Missense_MutationNAA28V0.5
GBMchr12131916488Nonsense_Mutationrs373878374R657*0.32
GBMchr12131913235Silentrs561387032P378P0.58
GBMchr12131895036Missense_MutationnovelG12D0.27
HNSCchr12131919996Missense_MutationnovelE941K0.2
HNSCchr12131908666Missense_MutationnovelD113E0.32RIO1
HNSCchr12131908958Missense_MutationnovelS184F0.21
HNSCchr12131919992SilentnovelL939L0.09
HNSCchr12131915418Missense_MutationnovelP536A0.39
HNSCchr12131920104Nonsense_MutationnovelE977*0.28
HNSCchr12131921316SilentnovelC1036C0.06
HNSCchr12131916955Missense_MutationnovelS692F0.09
HNSCchr12131916557Missense_Mutationrs147399196R680W0.11
HNSCchr121319214363'UTRnovel0.38
KIRCchr12131912090Splice_SitenovelX366_splice0.29
KIRCchr12131915926Missense_Mutationrs752880506G549R0.2
KIRPchr12131910752Silentrs571147302S300S0.36
KIRPchr12131908912Missense_MutationNAA169T0.46
KIRPchr12131921168SilentNAA1010A0.54
LGGchr12131907519Missense_MutationnovelD102N0.12RIO1
LIHCchr12131921148Missense_Mutationrs202232188V1004I0.26
LIHCchr12131908787Missense_MutationNAA154S0.45
LIHCchr12131912088Splice_RegionNAP365P0.52
LUADchr121319214913'UTRnovel0.29
LUADchr12131913217SilentnovelA372A0.19
LUADchr12131917017Missense_MutationNAD713Y0.3
LUADchr12131916150SilentNAS623S0.3
LUADchr12131912079SilentnovelA362A0.23
LUADchr12131909934SilentNAT247T0.24
LUADchr12131919257Missense_MutationNAF853V0.38
LUADchr12131917017Missense_MutationNAD713Y0.32
LUADchr12131915174Missense_MutationNAV489F0.44
LUADchr12131908782Missense_MutationNAR152L0.15
LUADchr12131916091Missense_MutationnovelG604C0.24
LUSCchr12131908739Missense_MutationnovelD138N0.35RIO1
LUSCchr12131909948Missense_MutationnovelR252L0.48
LUSCchr12131909195SilentnovelG208G0.18
LUSCchr12131919543Missense_MutationnovelD919V0.33
LUSCchr12131911986Frame_Shift_DelnovelA332Hfs*200.41
LUSCchr12131908955Missense_MutationnovelG183V0.33
LUSCchr12131915105Missense_MutationnovelG466C0.17
LUSCchr12131916970Missense_MutationnovelR697L0.37
LUSCchr12131908907Missense_MutationnovelG167A0.1
LUSCchr12131915398Missense_MutationnovelR529L0.44
LUSCchr12131916450Missense_MutationnovelA644V0.11
LUSCchr12131916064Missense_MutationNAG595R0.45
LUSCchr12131918591Silentrs371788092H807H0.22
OVchr12131909995Missense_MutationnovelD268H0.27
PAADchr12131911985Missense_Mutationrs745463834P331L0.58
PAADchr12131908739Missense_MutationnovelD138N0.26RIO1
PAADchr12131909975Missense_Mutationrs377295019R261H0.19
PAADchr12131921352SilentnovelI1048I0.22
PRADchr12131917521Frame_Shift_DelNAQ767Rfs*570.3
PRADchr12131918611Missense_MutationnovelP814L0.45
READchr12131921359Nonstop_MutationNA*1051Gext*360.31
READchr12131916088Missense_Mutationrs142452051R603W0.26
READchr12131917038SilentNAL720L0.29
SARCchr12131915393SilentnovelE527E0.16
SARCchr12131917492Missense_MutationnovelT755I0.13
SARCchr12131918529Missense_Mutationrs374570609R787C0.35
SKCMchr12131913829Missense_MutationNAP414S0.32
SKCMchr12131916149Missense_MutationnovelS623F0.44
SKCMchr12131915976Silentrs144046347V565V0.52
SKCMchr12131913797Missense_Mutationrs774045851S403F0.34
SKCMchr12131916409SilentNAS630S0.28
SKCMchr12131908759SilentNAI144I0.27
SKCMchr12131910279Silentrs747581505L278L0.48
SKCMchr12131914466SilentnovelF454F0.47
SKCMchr121319213893'UTRnovel0.52
SKCMchr12131908789SilentnovelA154A0.26
SKCMchr12131916405Missense_MutationNAP629L0.14
SKCMchr12131915412Missense_MutationnovelP534S0.16
SKCMchr12131915413Missense_Mutationrs369296208P534L0.16
SKCMchr12131919259Silentrs139624236F853F0.16
SKCMchr12131916526Silentrs200684485P669P0.8
SKCMchr12131913822SilentNAS411S0.28
SKCMchr12131908918Missense_MutationnovelY171H0.11
SKCMchr12131911943Missense_MutationNAS317F0.16
SKCMchr12131921184Missense_MutationNAG1016R0.35
SKCMchr12131916408Missense_MutationNAS630F0.17
SKCMchr121319213853'UTRnovel0.38
SKCMchr12131917452Missense_Mutationrs569526446R742C0.45
SKCMchr12131921141SilentNAE1001E0.33
SKCMchr12131915936Missense_MutationNAC552Y0.5
SKCMchr12131919217SilentnovelE839E0.17
SKCMchr12131916582Missense_Mutationrs750594593P688L0.24
SKCMchr12131910294Silentrs548811285S283S0.13
SKCMchr12131914407Missense_MutationNAP435S0.5
SKCMchr12131917478Silentrs374869166S750S0.4
SKCMchr12131914367SilentnovelF421F0.36
SKCMchr12131910782SilentnovelS310S0.49
SKCMchr12131910781Missense_MutationNAS310F0.5
SKCMchr12131910713Splice_RegionnovelS287S0.6
SKCMchr12131914353Missense_Mutationrs758686407R417W0.4
SKCMchr12131914396Missense_MutationnovelP431L0.73
STADchr12131917536Missense_MutationnovelR770C0.25
STADchr12131917521Frame_Shift_DelNAQ767Rfs*570.3
STADchr12131908737Missense_Mutationrs751254383R137H0.27RIO1
STADchr12131895811Missense_MutationNAL78Q0.11RIO1
STADchr12131917521Frame_Shift_DelNAQ767Rfs*570.65
STADchr12131915948Missense_MutationNAS556I0.31
STADchr12131909947Missense_MutationNAR252W0.29
STADchr12131908737Missense_Mutationrs751254383R137H0.33RIO1
STADchr12131918589Missense_MutationnovelH807Y0.25
STADchr121319214773'UTRnovel0.57
STADchr12131908936Missense_MutationNAM177V0.1
STADchr12131909944SilentNAL251L0.22
STADchr12131914382Silentrs772840184C426C0.18
STADchr12131916482Frame_Shift_DelnovelP656Lfs*1680.24
STADchr12131909974Missense_MutationNAR261C0.18
STADchr12131919313Frame_Shift_DelNAG873Afs*180.15
STADchr121319214533'UTRnovel0.35
STADchr12131915917Missense_Mutationrs200272214R546C0.3
STADchr12131918576Silentrs753118432L802L0.17
STADchr12131909807SilentnovelY233Y0.23
STADchr12131919566Missense_MutationnovelC927R0.15
STADchr12131919478Silentrs780528784A897A0.07
STADchr12131915981Missense_Mutationrs192583536R567H0.3
STADchr12131915372Silentrs766016454T520T0.18
STADchr12131919247SilentnovelF849F0.38
STADchr12131911951Missense_Mutationrs138390533E320K0.23
STADchr12131919217Missense_MutationNAE839D0.27
STADchr12131919249Missense_Mutationrs147409347T850M0.17
STADchr12131910787Missense_Mutationrs775402283L312P0.32
STADchr12131916481Frame_Shift_InsnovelR657Sfs*440.12
STADchr12131916462Missense_MutationNAR648L0.14
TGCTchr12131908786Frame_Shift_InsnovelI159Qfs*110.15
TGCTchr12131919587Missense_Mutationrs766989906Q934K0.18
UCECchr12131910262Missense_MutationNAF273V0.32
UCECchr12131917551Missense_Mutationrs540811369S775P0.39
UCECchr12131916489Missense_MutationNAR657Q0.16
UCECchr121319214813'UTRnovel0.18
UCECchr121319214053'UTRnovel0.45
UCECchr121319226003'UTRnovel0.6
UCECchr12131919477Missense_Mutationrs770028247A897V0.54
UCECchr12131895656Missense_MutationNAS56Y0.25RIO1
UCECchr12131917453Missense_Mutationrs538260523R742H0.45
UCECchr12131914446Missense_MutationnovelL448M0.16
UCECchr12131910280Missense_MutationnovelD279N0.13
UCECchr121319218873'UTRnovel0.4
UCECchr121319218043'UTRrs7510032460.45
UCECchr12131919249Missense_Mutationrs147409347T850M0.81
UCECchr12131916105SilentnovelL608L0.2
UCECchr12131917538SilentnovelR770R0.28
UCECchr12131917521Frame_Shift_DelNAQ767Rfs*570.16
UCECchr12131915416Missense_MutationnovelR535H0.33
UCECchr12131917016Silentrs140491730P712P0.42
UCECchr12131915998Frame_Shift_DelNAT575Rfs*720.42
UCECchr12131920124Silentrs753406496H983H0.09
UCECchr12131921154Missense_MutationNAR1006C0.16
UCECchr121319213953'UTRrs7508713730.28
UCECchr121319219403'UTRnovel0.58
UCECchr12131915998Frame_Shift_DelNAT575Rfs*720.46
UCECchr12131915998Frame_Shift_DelNAT575Rfs*720.41
UCECchr12131918565Missense_MutationnovelA799T0.08
UCECchr12131907503Silentrs371409689N96N0.26
UCECchr12131909228Silentrs774163203A219A0.31
UCECchr12131915917Missense_Mutationrs200272214R546C0.39
UCECchr12131916126Frame_Shift_DelnovelL617Cfs*300.11
UCECchr12131907501Missense_MutationnovelN96D0.31RIO1
UCECchr12131910773SilentnovelS307S0.35
UCECchr12131916463SilentnovelR648R0.06
UCECchr12131916428Missense_MutationNAP637S0.11
UCECchr12131910766Missense_MutationnovelS305N0.33
UCECchr12131912064SilentNAF357F0.21
UCECchr12131915084Missense_MutationnovelS459P0.38
UCECchr12131917508Silentrs373095783P760P0.42
UCECchr121319219613'UTRnovel0.11
UCECchr12131911996Missense_Mutationrs768685353A335T0.31
UCECchr12131916488Nonsense_Mutationrs373878374R657*0.33
UCECchr121319227563'UTRnovel0.33
UCECchr12131908953SilentnovelC182C0.36
UCECchr12131909202Missense_Mutationrs748566843V211I0.31
UCECchr12131914432Missense_MutationnovelR443H0.24
UCECchr12131918591Silentrs371788092H807H0.22
UCECchr12131910724Missense_MutationnovelP291R0.38
UCECchr12131907516Missense_MutationnovelA101T0.1RIO1
UCECchr12131916541Silentrs375776903P674P0.16
UCECchr121319227083'UTRnovel0.47
UCECchr12131917520Frame_Shift_InsnovelQ767Pfs*350.31
UCECchr12131917458Frame_Shift_DelnovelG745Afs*790.29
UCECchr12131906902Missense_MutationNAN86T0.32RIO1
UCECchr121319215163'UTRnovel0.37
UCECchr12131916462Missense_Mutationrs555905698R648Q0.41
UCECchr12131895826Splice_SitenovelX82_splice0.46
UCECchr12131909154Missense_MutationnovelS195P0.35
UCECchr12131915918Missense_Mutationrs146175892R546H0.33
UCECchr12131919491Missense_MutationnovelL902M0.38
UCECchr121319227293'UTRnovel0.32
UCSchr12131921154Missense_MutationNAR1006C0.34
UVMchr12131911950Silentrs756270836G319G0.53

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCADEL0.15440.22328
BRCADEL0.15936.3933e-07
CHOLDEL0.19440.067545
HNSCDEL0.07850.22646
LIHCDEL0.12432.3723e-05
LUADDEL0.16090.0059643
LUSCDEL0.12180.038823
OVDEL0.33689.8572e-12
PAADDEL0.17390.0030251
PRADDEL0.07110.024258
SKCMDEL0.18530.00079981
UCECDEL0.09090.00053229
UCSDEL0.33930.033261

Survival Analysis
CancerP-value Q-value
KIRC0.0001

Kaplan-Meier Survival Analysis

SKCM0.00022

Kaplan-Meier Survival Analysis

COAD0.0001

Kaplan-Meier Survival Analysis

PAAD0.0066

Kaplan-Meier Survival Analysis

KICH0.046

Kaplan-Meier Survival Analysis

UCEC0.0063

Kaplan-Meier Survival Analysis

GBM0.036

Kaplan-Meier Survival Analysis

THCA0.012

Kaplan-Meier Survival Analysis

UVM0.048

Kaplan-Meier Survival Analysis

Drugs

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Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000177169 (Gene tree)
Gene ID
8408
Gene Symbol
ULK1
Alias
ATG1|ATG1A
Full Name
unc-51 like autophagy activating kinase 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
28,517 bases
Position
chr12:131,894,651-131,923,167
Accession
12558
RBP type
canonical RBP
Summary
ULK1 (Unc-51 Like Autophagy Activating Kinase 1) is a Protein Coding gene. Diseases associated with ULK1 include Loeys-Dietz Syndrome 2 and Juvenile Spinal Muscular Atrophy. Among its related pathways are mTOR signaling pathway (KEGG) and Mitophagy - animal. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ULK2.
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000324560RIO1PF01163.220.0002811

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
30973873Dhh1 promotes autophagy-related protein translation during nitrogen starvation.PLoS Biol2019 Apr 11Liu Xdoi: 10.1371/journal.pbio.3000219
31234698Autophagic death of neural stem cells mediates chronic stress-induced decline of adult hippocampal neurogenesis and cognitive deficits.Autophagy2019 Jun 24:1-19Jung Sdoi: 10.1080/15548627.2019.1630222
31238788PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma.Autophagy2019 Jun 25:1-20Sarkar Cdoi: 10.1080/15548627.2019.1628538
30917721Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis.Autophagy2019 SepFernandez-Mosquera Ldoi: 10.1080/15548627.2019.1586256
30209975Thyroid hormone (T3) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy.Autophagy2019 JanYau WWdoi: 10.1080/15548627.2018.1511263
29130360Autophagy and innate immunity: Insights from invertebrate model organisms.Autophagy2018Kuo CJdoi: 10.1080/15548627.2017.1389824
30982460HIF1A and NFAT5 coordinate Na+-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting.Autophagy2019 Apr 14:1-18Neubert Pdoi: 10.1080/15548627.2019.1596483
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000544718ULK1-2071678--- (aa)--
ENST00000542313ULK1-206307--- (aa)--
ENST00000321867ULK1-2015310XM_011538798ENSP000003245601050 (aa)XP_011537100O75385
ENST00000537421ULK1-202959--- (aa)--
ENST00000540568ULK1-2032145--- (aa)--
ENST00000540647ULK1-2041211--- (aa)--
ENST00000541761ULK1-2051262--- (aa)--
Gene Model
Click here to download ENSG00000177169's gene model file
Pathways
Pathway IDPathway NameSource
hsa04137Mitophagy - animalKEGG
hsa04140Autophagy - animalKEGG
hsa04150mTOR signaling pathwayKEGG
hsa04152AMPK signaling pathwayKEGG
hsa04211Longevity regulating pathwayKEGG
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000177169rs7866144212131920499?General cognitive ability29844566z-score increase4.433EFO_0004337
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000177169's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000177169ULK19783.137ENSAMEG00000013726ULK110083.627Ailuropoda_melanoleuca
ENSG00000177169ULK19774.206ENSAPLG00000014729ULK19974.591Anas_platyrhynchos
ENSG00000177169ULK110097.048ENSCJAG00000003693ULK110097.048Callithrix_jacchus
ENSG00000177169ULK110089.962ENSCHIG00000018901ULK110090.436Capra_hircus
ENSG00000177169ULK19690.659ENSTSYG00000032371ULK19690.560Carlito_syrichta
ENSG00000177169ULK110088.297ENSCPOG00000001024ULK110088.297Cavia_porcellus
ENSG00000177169ULK110093.175ENSCATG00000024995ULK110093.340Cercocebus_atys
ENSG00000177169ULK110097.714ENSCSAG00000001882ULK19897.714Chlorocebus_sabaeus
ENSG00000177169ULK110089.564ENSCGRG00001020729Ulk110089.753Cricetulus_griseus_chok1gshd
ENSG00000177169ULK19989.539ENSCGRG00000004904Ulk110089.731Cricetulus_griseus_crigri
ENSG00000177169ULK110090.814ENSEASG00005016522ULK110091.004Equus_asinus_asinus
ENSG00000177169ULK110090.814ENSECAG00000016158ULK110091.440Equus_caballus
ENSG00000177169ULK110089.489ENSFCAG00000010779ULK110090.057Felis_catus
ENSG00000177169ULK19971.895ENSFALG00000008276ULK19872.217Ficedula_albicollis
ENSG00000177169ULK19974.858ENSGALG00000002403ULK19975.047Gallus_gallus
ENSG00000177169ULK19873.007ENSGAGG00000002662ULK19873.487Gopherus_agassizii
ENSG00000177169ULK110087.216ENSHGLG00000016386ULK110087.879Heterocephalus_glaber_female
ENSG00000177169ULK19983.789ENSLAFG00000003503ULK19984.166Loxodonta_africana
ENSG00000177169ULK110097.714ENSMNEG00000034338ULK110097.714Macaca_nemestrina
ENSG00000177169ULK110092.381ENSMICG00000011757ULK110092.476Microcebus_murinus
ENSG00000177169ULK110088.994ENSMOCG00000014550Ulk110089.374Microtus_ochrogaster
ENSG00000177169ULK19975.283ENSMODG00000015566ULK19975.189Monodelphis_domestica
ENSG00000177169ULK110089.089MGP_CAROLIEiJ_G0027552Ulk110089.279Mus_caroli
ENSG00000177169ULK110089.279ENSMUSG00000029512Ulk110089.469Mus_musculus
ENSG00000177169ULK110089.005MGP_PahariEiJ_G0024134Ulk110089.194Mus_pahari
ENSG00000177169ULK110089.279MGP_SPRETEiJ_G0028550Ulk110089.469Mus_spretus
ENSG00000177169ULK110089.848ENSNGAG00000007610Ulk110090.038Nannospalax_galili
ENSG00000177169ULK110098.190ENSNLEG00000008460ULK110098.190Nomascus_leucogenys
ENSG00000177169ULK18486.885ENSOPRG00000002632-8486.885Ochotona_princeps
ENSG00000177169ULK110087.347ENSODEG00000008683ULK110087.347Octodon_degus
ENSG00000177169ULK19974.388ENSOANG00000013859ULK19974.388Ornithorhynchus_anatinus
ENSG00000177169ULK19989.364ENSOCUG00000015070ULK19989.364Oryctolagus_cuniculus
ENSG00000177169ULK110092.762ENSOGAG00000005056ULK110092.762Otolemur_garnettii
ENSG00000177169ULK19899.420ENSPPAG00000043077-10099.420Pan_paniscus
ENSG00000177169ULK19770.452ENSPSIG00000008801ULK110070.837Pelodiscus_sinensis
ENSG00000177169ULK19989.037ENSPEMG00000010074Ulk110089.228Peromyscus_maniculatus_bairdii
ENSG00000177169ULK19978.544ENSPCIG00000006060ULK19978.450Phascolarctos_cinereus
ENSG00000177169ULK18585.762ENSPCAG00000004814ULK110086.652Procavia_capensis
ENSG00000177169ULK110093.048ENSPCOG00000001314ULK110093.143Propithecus_coquereli
ENSG00000177169ULK110088.899ENSRNOG00000037505Ulk110089.089Rattus_norvegicus
ENSG00000177169ULK110097.333ENSRBIG00000042231ULK110097.333Rhinopithecus_bieti
ENSG00000177169ULK19977.996ENSSHAG00000013399ULK19977.715Sarcophilus_harrisii
ENSG00000177169ULK110090.246ENSSSCG00000009742ULK110090.720Sus_scrofa
ENSG00000177169ULK19368.844ENSXETG00000002028ulk19969.447Xenopus_tropicalis
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000045autophagosome assembly21873635.IBAProcess
GO:0000407phagophore assembly site21873635.IBAComponent
GO:0004674protein serine/threonine kinase activity21873635.IBAFunction
GO:0004674protein serine/threonine kinase activity18936157.25126726.27103069.IDAFunction
GO:0004674protein serine/threonine kinase activity9693035.NASFunction
GO:0004674protein serine/threonine kinase activity-TASFunction
GO:0005515protein binding11146101.17389358.18936157.19211835.19597335.20562859.21072212.22354037.22613832.23392225.23524951.24290141.24603492.25126726.25127057.25438055.25686248.25891078.26347139.26593251.27334615.28195531.28561066.29950492.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005737cytoplasm9693035.NASComponent
GO:0005741mitochondrial outer membrane-TASComponent
GO:0005776autophagosome17595159.22456507.IDAComponent
GO:0005789endoplasmic reticulum membrane-TASComponent
GO:0005829cytosol21873635.IBAComponent
GO:0005829cytosol11146101.IDAComponent
GO:0005829cytosol-TASComponent
GO:0006468protein phosphorylation9693035.NASProcess
GO:0006914autophagy18936157.IDAProcess
GO:0006914autophagy17595159.IMPProcess
GO:0006914autophagy-ISSProcess
GO:0007165signal transduction-IEAProcess
GO:0008104protein localization16940348.IMPProcess
GO:0010506regulation of autophagy21873635.IBAProcess
GO:0016020membrane21873635.IBAComponent
GO:0016236macroautophagy22354037.IMPProcess
GO:0016236macroautophagy-TASProcess
GO:0016241regulation of macroautophagy-TASProcess
GO:0016301kinase activity-TASFunction
GO:0017137Rab GTPase binding22613832.IPIFunction
GO:0018105peptidyl-serine phosphorylation25126726.27103069.IDAProcess
GO:0018107peptidyl-threonine phosphorylation27103069.IDAProcess
GO:0030424axon-IEAComponent
GO:0031102neuron projection regeneration-IEAProcess
GO:0031175neuron projection development18007665.IMPProcess
GO:0031333negative regulation of protein complex assembly25126726.IDAProcess
GO:0031669cellular response to nutrient levels-ISSProcess
GO:0032045guanyl-nucleotide exchange factor complex27103069.IDAComponent
GO:0034045phagophore assembly site membrane18936157.IDAComponent
GO:0042594response to starvation-ISSProcess
GO:0042802identical protein binding20562859.23524951.IPIFunction
GO:0044877protein-containing complex binding19211835.IPIFunction
GO:0046777protein autophosphorylation21873635.IBAProcess
GO:0046777protein autophosphorylation18936157.IDAProcess
GO:0048675axon extension21873635.IBAProcess
GO:0051020GTPase binding25891078.IPIFunction
GO:0055037recycling endosome-TASComponent
GO:0075044autophagy of host cells involved in interaction with symbiont28389568.IGIProcess
GO:0097629extrinsic component of omegasome membrane22885598.IDAComponent
GO:0097632extrinsic component of phagophore assembly site membrane22885598.IDAComponent
GO:0097635extrinsic component of autophagosome membrane22885598.IDAComponent
GO:1990316Atg1/ULK1 kinase complex19211835.IPIComponent
GO:2000786positive regulation of autophagosome assembly-IEAProcess
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