EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28079894	MiR-26 enhances chemosensitivity and promotes apoptosis of hepatocellular carcinoma cells through inhibiting autophagy.	Cell Death Dis	2017 Jan 12	Jin F	doi: 10.1038/cddis.2016.461.
27687210	Lack of mitochondrial DNA impairs chemical hypoxia-induced autophagy in liver tumor cells through ROS-AMPK-ULK1 signaling dysregulation independently of HIF-1α.	Free Radic Biol Med	2016 Dec	Marin JJG	doi: 10.1016/j.freeradbiomed.2016.09.025
28639909	Silencing of NRAGE induces autophagy via AMPK/Ulk1/Atg13 signaling pathway in NSCLC cells.	Tumour Biol	2017 Jun	Zhou Y	doi: 10.1177/1010428317709676.
28410240	Ulk1 over-expression in human gastric cancer is correlated with patients' T classification and cancer relapse.	Oncotarget	2017 May 16	Chen MB	doi: 10.18632/oncotarget.16734.
24955726	Silencing of EEF2K (eukaryotic elongation factor-2 kinase) reveals AMPK-ULK1-dependent autophagy in colon cancer cells.	Autophagy	2014 Sep	Xie CM	doi: 10.4161/auto.29164
22585231	Low expression of ULK1 is associated with operable breast cancer progression and is an adverse prognostic marker of survival for patients.	Breast Cancer Res Treat	2012 Jul	Tang J	doi: 10.1007/s10549-012-2080-y
27679555	Elevated levels of autophagy-related marker ULK1 and mitochondrion-associated autophagy inhibitor LRPPRC are associated with biochemical progression and overall survival after androgen deprivation therapy in patients with metastatic prostate cancer.	J Clin Pathol	2017 May	Zhang HY	doi: 10.1136/jclinpath-2016-203926
28073914	Serine/Threonine Kinase Unc-51-like Kinase-1 (Ulk1) Phosphorylates the Co-chaperone Cell Division Cycle Protein 37 (Cdc37) and Thereby Disrupts the Stability of Cdc37 Client Proteins.	J Biol Chem	2017 Feb 17	Li R	doi: 10.1074/jbc.M116.762443
28498429	SBI0206965, a novel inhibitor of Ulk1, suppresses non-small cell lung cancer cell growth by modulating both autophagy and apoptosis pathways.	Oncol Rep	2017 Jun	Tang F	doi: 10.3892/or.2017.5635
27864418	AMPK-ULK1-Mediated Autophagy Confers Resistance to BET Inhibitor JQ1 in Acute Myeloid Leukemia Stem Cells.	Clin Cancer Res	2017 Jun 1	Jang JE	doi: 10.1158/1078-0432.CCR-16-1903
28614291	CLDN1 Increases Drug Resistance of Non-Small Cell Lung Cancer by Activating Autophagy via Up-Regulation of ULK1 Phosphorylation.	Med Sci Monit	2017 Jun 14	Zhao Z	-
29470986	Silencing of LncRNA-HOTAIR decreases drug resistance of Non-Small Cell Lung Cancer cells by inactivating autophagy via suppressing the phosphorylation of ULK1.	Biochem Biophys Res Commun	2018 Mar 18	Yang Y	doi: 10.1016/j.bbrc.2018.02.141
29091866	Combination of ULK1 and LC3B improve prognosis assessment of hepatocellular carcinoma.	Biomed Pharmacother	2018 Jan	Wu DH	doi: 10.1016/j.biopha.2017.10.025

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr12	131916592	Splice_Site	novel	X691_splice	0.59
BLCA	chr12	131895648	Silent	novel	L53L	0.28
BLCA	chr12	131915228	Missense_Mutation	novel	Q507E	0.33
BLCA	chr12	131919274	Silent	novel	L858L	0.63
BLCA	chr12	131920076	Silent	novel	L967L	0.2
BLCA	chr12	131919305	Missense_Mutation	NA	E869K	0.31
BLCA	chr12	131895788	Silent	rs371613349	L70L	0.13
BLCA	chr12	131919992	Silent	NA	L939L	0.15
BLCA	chr12	131895043	Missense_Mutation	novel	F14L	0.23
BLCA	chr12	131917536	Missense_Mutation	novel	R770C	0.36
BLCA	chr12	131921137	Missense_Mutation	rs749327954	R1000H	0.17
BLCA	chr12	131895002	Translation_Start_Site	NA	M1?	0.36
BLCA	chr12	131895819	Missense_Mutation	NA	F81L	0.11	RIO1
BLCA	chr12	131908730	Missense_Mutation	novel	I135V	0.39	RIO1
BRCA	chr12	131909215	Missense_Mutation	NA	L215P	0.14
BRCA	chr12	131920055	Silent	novel	F960F	0.46
BRCA	chr12	131911982	Missense_Mutation	NA	S330F	0.28
CESC	chr12	131915912	Missense_Mutation	rs150697369	S544C	0.56
CESC	chr12	131915088	Missense_Mutation	NA	S460C	0.39
CESC	chr12	131916153	Frame_Shift_Ins	novel	*T625Rfs23**	0.21
CESC	chr12	131916526	Frame_Shift_Ins	novel	*F670Dfs157**	0.08
CESC	chr12	131916469	Silent	rs138492147	G650G	0.4
CESC	chr12	131916567	Missense_Mutation	novel	E683G	0.38
CESC	chr12	131922663	3'UTR	novel		0.37
CESC	chr12	131916429	Frame_Shift_Ins	novel	*S638Ifs65**	0.04
COAD	chr12	131916470	Missense_Mutation	rs565402146	V651M	0.2
COAD	chr12	131922797	3'UTR	novel		0.83
COAD	chr12	131909834	Splice_Site	novel	X242_splice	0.1
COAD	chr12	131920084	Missense_Mutation	rs369823883	R970H	0.35
COAD	chr12	131921120	Silent	rs371996516	D994D	0.38
COAD	chr12	131917521	Frame_Shift_Del	NA	*Q767Rfs57**	0.45
COAD	chr12	131916428	Missense_Mutation	NA	P637T	0.39
COAD	chr12	131917521	Frame_Shift_Del	NA	*Q767Rfs57**	0.31
COAD	chr12	131895656	Missense_Mutation	NA	S56Y	0.38	RIO1
COAD	chr12	131915998	Frame_Shift_Del	NA	*T575Rfs72**	0.43
COAD	chr12	131908700	Missense_Mutation	NA	A125T	0.43	RIO1
COAD	chr12	131908914	Silent	novel	A169A	0.13
COAD	chr12	131911990	Missense_Mutation	novel	D333H	0.1
COAD	chr12	131910259	Frame_Shift_Del	NA	*H274Ifs109**	0.26
COAD	chr12	131918612	Silent	NA	P814P	0.65
COAD	chr12	131909941	Missense_Mutation	NA	P250S	0.38
COAD	chr12	131919269	Missense_Mutation	rs773571100	V857I	0.43
COAD	chr12	131908736	Missense_Mutation	novel	R137C	0.22	RIO1
COAD	chr12	131917016	Silent	rs140491730	P712P	0.36
COAD	chr12	131913217	Silent	rs757968994	A372A	0.5
COAD	chr12	131909931	Missense_Mutation	novel	E246D	0.21
COAD	chr12	131921219	Silent	rs138011167	I1027I	0.27
COAD	chr12	131919477	Missense_Mutation	rs770028247	A897V	0.32
COAD	chr12	131921337	Silent	rs117577371	A1043A	0.42
COAD	chr12	131910259	Frame_Shift_Del	NA	*H274Ifs109**	0.33
COAD	chr12	131916426	Frame_Shift_Del	NA	*S638Afs9**	0.32
COAD	chr12	131908700	Missense_Mutation	NA	A125T	0.19	RIO1
COAD	chr12	131919313	Frame_Shift_Del	NA	*G873Afs18**	0.22
COAD	chr12	131919556	Silent	rs143340589	A923A	0.18
COAD	chr12	131910290	Missense_Mutation	novel	P282H	0.29
ESCA	chr12	131911944	Splice_Region	novel	S317S	0.25
ESCA	chr12	131921167	Missense_Mutation	novel	A1010V	0.23
ESCA	chr12	131922890	3'UTR	novel		0.35
GBM	chr12	131895084	Missense_Mutation	NA	A28V	0.5
GBM	chr12	131916488	Nonsense_Mutation	rs373878374	R657*	0.32
GBM	chr12	131913235	Silent	rs561387032	P378P	0.58
GBM	chr12	131895036	Missense_Mutation	novel	G12D	0.27
HNSC	chr12	131919996	Missense_Mutation	novel	E941K	0.2
HNSC	chr12	131908666	Missense_Mutation	novel	D113E	0.32	RIO1
HNSC	chr12	131908958	Missense_Mutation	novel	S184F	0.21
HNSC	chr12	131919992	Silent	novel	L939L	0.09
HNSC	chr12	131915418	Missense_Mutation	novel	P536A	0.39
HNSC	chr12	131920104	Nonsense_Mutation	novel	E977*	0.28
HNSC	chr12	131921316	Silent	novel	C1036C	0.06
HNSC	chr12	131916955	Missense_Mutation	novel	S692F	0.09
HNSC	chr12	131916557	Missense_Mutation	rs147399196	R680W	0.11
HNSC	chr12	131921436	3'UTR	novel		0.38
KIRC	chr12	131912090	Splice_Site	novel	X366_splice	0.29
KIRC	chr12	131915926	Missense_Mutation	rs752880506	G549R	0.2
KIRP	chr12	131910752	Silent	rs571147302	S300S	0.36
KIRP	chr12	131908912	Missense_Mutation	NA	A169T	0.46
KIRP	chr12	131921168	Silent	NA	A1010A	0.54
LGG	chr12	131907519	Missense_Mutation	novel	D102N	0.12	RIO1
LIHC	chr12	131921148	Missense_Mutation	rs202232188	V1004I	0.26
LIHC	chr12	131908787	Missense_Mutation	NA	A154S	0.45
LIHC	chr12	131912088	Splice_Region	NA	P365P	0.52
LUAD	chr12	131921491	3'UTR	novel		0.29
LUAD	chr12	131913217	Silent	novel	A372A	0.19
LUAD	chr12	131917017	Missense_Mutation	NA	D713Y	0.3
LUAD	chr12	131916150	Silent	NA	S623S	0.3
LUAD	chr12	131912079	Silent	novel	A362A	0.23
LUAD	chr12	131909934	Silent	NA	T247T	0.24
LUAD	chr12	131919257	Missense_Mutation	NA	F853V	0.38
LUAD	chr12	131917017	Missense_Mutation	NA	D713Y	0.32
LUAD	chr12	131915174	Missense_Mutation	NA	V489F	0.44
LUAD	chr12	131908782	Missense_Mutation	NA	R152L	0.15
LUAD	chr12	131916091	Missense_Mutation	novel	G604C	0.24
LUSC	chr12	131908739	Missense_Mutation	novel	D138N	0.35	RIO1
LUSC	chr12	131909948	Missense_Mutation	novel	R252L	0.48
LUSC	chr12	131909195	Silent	novel	G208G	0.18
LUSC	chr12	131919543	Missense_Mutation	novel	D919V	0.33
LUSC	chr12	131911986	Frame_Shift_Del	novel	*A332Hfs20**	0.41
LUSC	chr12	131908955	Missense_Mutation	novel	G183V	0.33
LUSC	chr12	131915105	Missense_Mutation	novel	G466C	0.17
LUSC	chr12	131916970	Missense_Mutation	novel	R697L	0.37
LUSC	chr12	131908907	Missense_Mutation	novel	G167A	0.1
LUSC	chr12	131915398	Missense_Mutation	novel	R529L	0.44
LUSC	chr12	131916450	Missense_Mutation	novel	A644V	0.11
LUSC	chr12	131916064	Missense_Mutation	NA	G595R	0.45
LUSC	chr12	131918591	Silent	rs371788092	H807H	0.22
OV	chr12	131909995	Missense_Mutation	novel	D268H	0.27
PAAD	chr12	131911985	Missense_Mutation	rs745463834	P331L	0.58
PAAD	chr12	131908739	Missense_Mutation	novel	D138N	0.26	RIO1
PAAD	chr12	131909975	Missense_Mutation	rs377295019	R261H	0.19
PAAD	chr12	131921352	Silent	novel	I1048I	0.22
PRAD	chr12	131917521	Frame_Shift_Del	NA	*Q767Rfs57**	0.3
PRAD	chr12	131918611	Missense_Mutation	novel	P814L	0.45
READ	chr12	131921359	Nonstop_Mutation	NA	1051Gext36	0.31
READ	chr12	131916088	Missense_Mutation	rs142452051	R603W	0.26
READ	chr12	131917038	Silent	NA	L720L	0.29
SARC	chr12	131915393	Silent	novel	E527E	0.16
SARC	chr12	131917492	Missense_Mutation	novel	T755I	0.13
SARC	chr12	131918529	Missense_Mutation	rs374570609	R787C	0.35
SKCM	chr12	131913829	Missense_Mutation	NA	P414S	0.32
SKCM	chr12	131916149	Missense_Mutation	novel	S623F	0.44
SKCM	chr12	131915976	Silent	rs144046347	V565V	0.52
SKCM	chr12	131913797	Missense_Mutation	rs774045851	S403F	0.34
SKCM	chr12	131916409	Silent	NA	S630S	0.28
SKCM	chr12	131908759	Silent	NA	I144I	0.27
SKCM	chr12	131910279	Silent	rs747581505	L278L	0.48
SKCM	chr12	131914466	Silent	novel	F454F	0.47
SKCM	chr12	131921389	3'UTR	novel		0.52
SKCM	chr12	131908789	Silent	novel	A154A	0.26
SKCM	chr12	131916405	Missense_Mutation	NA	P629L	0.14
SKCM	chr12	131915412	Missense_Mutation	novel	P534S	0.16
SKCM	chr12	131915413	Missense_Mutation	rs369296208	P534L	0.16
SKCM	chr12	131919259	Silent	rs139624236	F853F	0.16
SKCM	chr12	131916526	Silent	rs200684485	P669P	0.8
SKCM	chr12	131913822	Silent	NA	S411S	0.28
SKCM	chr12	131908918	Missense_Mutation	novel	Y171H	0.11
SKCM	chr12	131911943	Missense_Mutation	NA	S317F	0.16
SKCM	chr12	131921184	Missense_Mutation	NA	G1016R	0.35
SKCM	chr12	131916408	Missense_Mutation	NA	S630F	0.17
SKCM	chr12	131921385	3'UTR	novel		0.38
SKCM	chr12	131917452	Missense_Mutation	rs569526446	R742C	0.45
SKCM	chr12	131921141	Silent	NA	E1001E	0.33
SKCM	chr12	131915936	Missense_Mutation	NA	C552Y	0.5
SKCM	chr12	131919217	Silent	novel	E839E	0.17
SKCM	chr12	131916582	Missense_Mutation	rs750594593	P688L	0.24
SKCM	chr12	131910294	Silent	rs548811285	S283S	0.13
SKCM	chr12	131914407	Missense_Mutation	NA	P435S	0.5
SKCM	chr12	131917478	Silent	rs374869166	S750S	0.4
SKCM	chr12	131914367	Silent	novel	F421F	0.36
SKCM	chr12	131910782	Silent	novel	S310S	0.49
SKCM	chr12	131910781	Missense_Mutation	NA	S310F	0.5
SKCM	chr12	131910713	Splice_Region	novel	S287S	0.6
SKCM	chr12	131914353	Missense_Mutation	rs758686407	R417W	0.4
SKCM	chr12	131914396	Missense_Mutation	novel	P431L	0.73
STAD	chr12	131917536	Missense_Mutation	novel	R770C	0.25
STAD	chr12	131917521	Frame_Shift_Del	NA	*Q767Rfs57**	0.3
STAD	chr12	131908737	Missense_Mutation	rs751254383	R137H	0.27	RIO1
STAD	chr12	131895811	Missense_Mutation	NA	L78Q	0.11	RIO1
STAD	chr12	131917521	Frame_Shift_Del	NA	*Q767Rfs57**	0.65
STAD	chr12	131915948	Missense_Mutation	NA	S556I	0.31
STAD	chr12	131909947	Missense_Mutation	NA	R252W	0.29
STAD	chr12	131908737	Missense_Mutation	rs751254383	R137H	0.33	RIO1
STAD	chr12	131918589	Missense_Mutation	novel	H807Y	0.25
STAD	chr12	131921477	3'UTR	novel		0.57
STAD	chr12	131908936	Missense_Mutation	NA	M177V	0.1
STAD	chr12	131909944	Silent	NA	L251L	0.22
STAD	chr12	131914382	Silent	rs772840184	C426C	0.18
STAD	chr12	131916482	Frame_Shift_Del	novel	*P656Lfs168**	0.24
STAD	chr12	131909974	Missense_Mutation	NA	R261C	0.18
STAD	chr12	131919313	Frame_Shift_Del	NA	*G873Afs18**	0.15
STAD	chr12	131921453	3'UTR	novel		0.35
STAD	chr12	131915917	Missense_Mutation	rs200272214	R546C	0.3
STAD	chr12	131918576	Silent	rs753118432	L802L	0.17
STAD	chr12	131909807	Silent	novel	Y233Y	0.23
STAD	chr12	131919566	Missense_Mutation	novel	C927R	0.15
STAD	chr12	131919478	Silent	rs780528784	A897A	0.07
STAD	chr12	131915981	Missense_Mutation	rs192583536	R567H	0.3
STAD	chr12	131915372	Silent	rs766016454	T520T	0.18
STAD	chr12	131919247	Silent	novel	F849F	0.38
STAD	chr12	131911951	Missense_Mutation	rs138390533	E320K	0.23
STAD	chr12	131919217	Missense_Mutation	NA	E839D	0.27
STAD	chr12	131919249	Missense_Mutation	rs147409347	T850M	0.17
STAD	chr12	131910787	Missense_Mutation	rs775402283	L312P	0.32
STAD	chr12	131916481	Frame_Shift_Ins	novel	*R657Sfs44**	0.12
STAD	chr12	131916462	Missense_Mutation	NA	R648L	0.14
TGCT	chr12	131908786	Frame_Shift_Ins	novel	*I159Qfs11**	0.15
TGCT	chr12	131919587	Missense_Mutation	rs766989906	Q934K	0.18
UCEC	chr12	131910262	Missense_Mutation	NA	F273V	0.32
UCEC	chr12	131917551	Missense_Mutation	rs540811369	S775P	0.39
UCEC	chr12	131916489	Missense_Mutation	NA	R657Q	0.16
UCEC	chr12	131921481	3'UTR	novel		0.18
UCEC	chr12	131921405	3'UTR	novel		0.45
UCEC	chr12	131922600	3'UTR	novel		0.6
UCEC	chr12	131919477	Missense_Mutation	rs770028247	A897V	0.54
UCEC	chr12	131895656	Missense_Mutation	NA	S56Y	0.25	RIO1
UCEC	chr12	131917453	Missense_Mutation	rs538260523	R742H	0.45
UCEC	chr12	131914446	Missense_Mutation	novel	L448M	0.16
UCEC	chr12	131910280	Missense_Mutation	novel	D279N	0.13
UCEC	chr12	131921887	3'UTR	novel		0.4
UCEC	chr12	131921804	3'UTR	rs751003246		0.45
UCEC	chr12	131919249	Missense_Mutation	rs147409347	T850M	0.81
UCEC	chr12	131916105	Silent	novel	L608L	0.2
UCEC	chr12	131917538	Silent	novel	R770R	0.28
UCEC	chr12	131917521	Frame_Shift_Del	NA	*Q767Rfs57**	0.16
UCEC	chr12	131915416	Missense_Mutation	novel	R535H	0.33
UCEC	chr12	131917016	Silent	rs140491730	P712P	0.42
UCEC	chr12	131915998	Frame_Shift_Del	NA	*T575Rfs72**	0.42
UCEC	chr12	131920124	Silent	rs753406496	H983H	0.09
UCEC	chr12	131921154	Missense_Mutation	NA	R1006C	0.16
UCEC	chr12	131921395	3'UTR	rs750871373		0.28
UCEC	chr12	131921940	3'UTR	novel		0.58
UCEC	chr12	131915998	Frame_Shift_Del	NA	*T575Rfs72**	0.46
UCEC	chr12	131915998	Frame_Shift_Del	NA	*T575Rfs72**	0.41
UCEC	chr12	131918565	Missense_Mutation	novel	A799T	0.08
UCEC	chr12	131907503	Silent	rs371409689	N96N	0.26
UCEC	chr12	131909228	Silent	rs774163203	A219A	0.31
UCEC	chr12	131915917	Missense_Mutation	rs200272214	R546C	0.39
UCEC	chr12	131916126	Frame_Shift_Del	novel	*L617Cfs30**	0.11
UCEC	chr12	131907501	Missense_Mutation	novel	N96D	0.31	RIO1
UCEC	chr12	131910773	Silent	novel	S307S	0.35
UCEC	chr12	131916463	Silent	novel	R648R	0.06
UCEC	chr12	131916428	Missense_Mutation	NA	P637S	0.11
UCEC	chr12	131910766	Missense_Mutation	novel	S305N	0.33
UCEC	chr12	131912064	Silent	NA	F357F	0.21
UCEC	chr12	131915084	Missense_Mutation	novel	S459P	0.38
UCEC	chr12	131917508	Silent	rs373095783	P760P	0.42
UCEC	chr12	131921961	3'UTR	novel		0.11
UCEC	chr12	131911996	Missense_Mutation	rs768685353	A335T	0.31
UCEC	chr12	131916488	Nonsense_Mutation	rs373878374	R657*	0.33
UCEC	chr12	131922756	3'UTR	novel		0.33
UCEC	chr12	131908953	Silent	novel	C182C	0.36
UCEC	chr12	131909202	Missense_Mutation	rs748566843	V211I	0.31
UCEC	chr12	131914432	Missense_Mutation	novel	R443H	0.24
UCEC	chr12	131918591	Silent	rs371788092	H807H	0.22
UCEC	chr12	131910724	Missense_Mutation	novel	P291R	0.38
UCEC	chr12	131907516	Missense_Mutation	novel	A101T	0.1	RIO1
UCEC	chr12	131916541	Silent	rs375776903	P674P	0.16
UCEC	chr12	131922708	3'UTR	novel		0.47
UCEC	chr12	131917520	Frame_Shift_Ins	novel	*Q767Pfs35**	0.31
UCEC	chr12	131917458	Frame_Shift_Del	novel	*G745Afs79**	0.29
UCEC	chr12	131906902	Missense_Mutation	NA	N86T	0.32	RIO1
UCEC	chr12	131921516	3'UTR	novel		0.37
UCEC	chr12	131916462	Missense_Mutation	rs555905698	R648Q	0.41
UCEC	chr12	131895826	Splice_Site	novel	X82_splice	0.46
UCEC	chr12	131909154	Missense_Mutation	novel	S195P	0.35
UCEC	chr12	131915918	Missense_Mutation	rs146175892	R546H	0.33
UCEC	chr12	131919491	Missense_Mutation	novel	L902M	0.38
UCEC	chr12	131922729	3'UTR	novel		0.32
UCS	chr12	131921154	Missense_Mutation	NA	R1006C	0.34
UVM	chr12	131911950	Silent	rs756270836	G319G	0.53

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.1544	0.22328
BRCA	DEL	0.1593	6.3933e-07
CHOL	DEL	0.1944	0.067545
HNSC	DEL	0.0785	0.22646
LIHC	DEL	0.1243	2.3723e-05
LUAD	DEL	0.1609	0.0059643
LUSC	DEL	0.1218	0.038823
OV	DEL	0.3368	9.8572e-12
PAAD	DEL	0.1739	0.0030251
PRAD	DEL	0.0711	0.024258
SKCM	DEL	0.1853	0.00079981
UCEC	DEL	0.0909	0.00053229
UCS	DEL	0.3393	0.033261

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
SKCM	0.00022	Kaplan-Meier Survival Analysis
COAD	0.0001	Kaplan-Meier Survival Analysis
PAAD	0.0066	Kaplan-Meier Survival Analysis
KICH	0.046	Kaplan-Meier Survival Analysis
UCEC	0.0063	Kaplan-Meier Survival Analysis
GBM	0.036	Kaplan-Meier Survival Analysis
THCA	0.012	Kaplan-Meier Survival Analysis
UVM	0.048	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000177169 (Gene tree)
Gene ID: 8408
Gene Symbol: ULK1
Alias: ATG1|ATG1A
Full Name: unc-51 like autophagy activating kinase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 28,517 bases
Position: chr12:131,894,651-131,923,167
Accession: 12558
RBP type: canonical RBP
Summary: ULK1 (Unc-51 Like Autophagy Activating Kinase 1) is a Protein Coding gene. Diseases associated with ULK1 include Loeys-Dietz Syndrome 2 and Juvenile Spinal Muscular Atrophy. Among its related pathways are mTOR signaling pathway (KEGG) and Mitophagy - animal. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ULK2.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000324560	RIO1	PF01163.22	0.00028	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
30973873	Dhh1 promotes autophagy-related protein translation during nitrogen starvation.	PLoS Biol	2019 Apr 11	Liu X	doi: 10.1371/journal.pbio.3000219
31234698	Autophagic death of neural stem cells mediates chronic stress-induced decline of adult hippocampal neurogenesis and cognitive deficits.	Autophagy	2019 Jun 24:1-19	Jung S	doi: 10.1080/15548627.2019.1630222
31238788	PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma.	Autophagy	2019 Jun 25:1-20	Sarkar C	doi: 10.1080/15548627.2019.1628538
30917721	Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis.	Autophagy	2019 Sep	Fernandez-Mosquera L	doi: 10.1080/15548627.2019.1586256
30209975	Thyroid hormone (T3) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy.	Autophagy	2019 Jan	Yau WW	doi: 10.1080/15548627.2018.1511263
29130360	Autophagy and innate immunity: Insights from invertebrate model organisms.	Autophagy	2018	Kuo CJ	doi: 10.1080/15548627.2017.1389824
30982460	HIF1A and NFAT5 coordinate Na+-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting.	Autophagy	2019 Apr 14:1-18	Neubert P	doi: 10.1080/15548627.2019.1596483

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000544718	ULK1-207	1678	-	-	- (aa)	-	-
ENST00000542313	ULK1-206	307	-	-	- (aa)	-	-
ENST00000321867	ULK1-201	5310	XM_011538798	ENSP00000324560	1050 (aa)	XP_011537100	O75385
ENST00000537421	ULK1-202	959	-	-	- (aa)	-	-
ENST00000540568	ULK1-203	2145	-	-	- (aa)	-	-
ENST00000540647	ULK1-204	1211	-	-	- (aa)	-	-
ENST00000541761	ULK1-205	1262	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000177169's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04137	Mitophagy - animal	KEGG
hsa04140	Autophagy - animal	KEGG
hsa04150	mTOR signaling pathway	KEGG
hsa04152	AMPK signaling pathway	KEGG
hsa04211	Longevity regulating pathway	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000177169	rs78661442	12	131920499	?	General cognitive ability	29844566	z-score increase	4.433	EFO_0004337

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000177169's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000177169	ULK1	97	83.137	ENSAMEG00000013726	ULK1	100	83.627	Ailuropoda_melanoleuca
ENSG00000177169	ULK1	97	74.206	ENSAPLG00000014729	ULK1	99	74.591	Anas_platyrhynchos
ENSG00000177169	ULK1	100	97.048	ENSCJAG00000003693	ULK1	100	97.048	Callithrix_jacchus
ENSG00000177169	ULK1	100	89.962	ENSCHIG00000018901	ULK1	100	90.436	Capra_hircus
ENSG00000177169	ULK1	96	90.659	ENSTSYG00000032371	ULK1	96	90.560	Carlito_syrichta
ENSG00000177169	ULK1	100	88.297	ENSCPOG00000001024	ULK1	100	88.297	Cavia_porcellus
ENSG00000177169	ULK1	100	93.175	ENSCATG00000024995	ULK1	100	93.340	Cercocebus_atys
ENSG00000177169	ULK1	100	97.714	ENSCSAG00000001882	ULK1	98	97.714	Chlorocebus_sabaeus
ENSG00000177169	ULK1	100	89.564	ENSCGRG00001020729	Ulk1	100	89.753	Cricetulus_griseus_chok1gshd
ENSG00000177169	ULK1	99	89.539	ENSCGRG00000004904	Ulk1	100	89.731	Cricetulus_griseus_crigri
ENSG00000177169	ULK1	100	90.814	ENSEASG00005016522	ULK1	100	91.004	Equus_asinus_asinus
ENSG00000177169	ULK1	100	90.814	ENSECAG00000016158	ULK1	100	91.440	Equus_caballus
ENSG00000177169	ULK1	100	89.489	ENSFCAG00000010779	ULK1	100	90.057	Felis_catus
ENSG00000177169	ULK1	99	71.895	ENSFALG00000008276	ULK1	98	72.217	Ficedula_albicollis
ENSG00000177169	ULK1	99	74.858	ENSGALG00000002403	ULK1	99	75.047	Gallus_gallus
ENSG00000177169	ULK1	98	73.007	ENSGAGG00000002662	ULK1	98	73.487	Gopherus_agassizii
ENSG00000177169	ULK1	100	87.216	ENSHGLG00000016386	ULK1	100	87.879	Heterocephalus_glaber_female
ENSG00000177169	ULK1	99	83.789	ENSLAFG00000003503	ULK1	99	84.166	Loxodonta_africana
ENSG00000177169	ULK1	100	97.714	ENSMNEG00000034338	ULK1	100	97.714	Macaca_nemestrina
ENSG00000177169	ULK1	100	92.381	ENSMICG00000011757	ULK1	100	92.476	Microcebus_murinus
ENSG00000177169	ULK1	100	88.994	ENSMOCG00000014550	Ulk1	100	89.374	Microtus_ochrogaster
ENSG00000177169	ULK1	99	75.283	ENSMODG00000015566	ULK1	99	75.189	Monodelphis_domestica
ENSG00000177169	ULK1	100	89.089	MGP_CAROLIEiJ_G0027552	Ulk1	100	89.279	Mus_caroli
ENSG00000177169	ULK1	100	89.279	ENSMUSG00000029512	Ulk1	100	89.469	Mus_musculus
ENSG00000177169	ULK1	100	89.005	MGP_PahariEiJ_G0024134	Ulk1	100	89.194	Mus_pahari
ENSG00000177169	ULK1	100	89.279	MGP_SPRETEiJ_G0028550	Ulk1	100	89.469	Mus_spretus
ENSG00000177169	ULK1	100	89.848	ENSNGAG00000007610	Ulk1	100	90.038	Nannospalax_galili
ENSG00000177169	ULK1	100	98.190	ENSNLEG00000008460	ULK1	100	98.190	Nomascus_leucogenys
ENSG00000177169	ULK1	84	86.885	ENSOPRG00000002632	-	84	86.885	Ochotona_princeps
ENSG00000177169	ULK1	100	87.347	ENSODEG00000008683	ULK1	100	87.347	Octodon_degus
ENSG00000177169	ULK1	99	74.388	ENSOANG00000013859	ULK1	99	74.388	Ornithorhynchus_anatinus
ENSG00000177169	ULK1	99	89.364	ENSOCUG00000015070	ULK1	99	89.364	Oryctolagus_cuniculus
ENSG00000177169	ULK1	100	92.762	ENSOGAG00000005056	ULK1	100	92.762	Otolemur_garnettii
ENSG00000177169	ULK1	98	99.420	ENSPPAG00000043077	-	100	99.420	Pan_paniscus
ENSG00000177169	ULK1	97	70.452	ENSPSIG00000008801	ULK1	100	70.837	Pelodiscus_sinensis
ENSG00000177169	ULK1	99	89.037	ENSPEMG00000010074	Ulk1	100	89.228	Peromyscus_maniculatus_bairdii
ENSG00000177169	ULK1	99	78.544	ENSPCIG00000006060	ULK1	99	78.450	Phascolarctos_cinereus
ENSG00000177169	ULK1	85	85.762	ENSPCAG00000004814	ULK1	100	86.652	Procavia_capensis
ENSG00000177169	ULK1	100	93.048	ENSPCOG00000001314	ULK1	100	93.143	Propithecus_coquereli
ENSG00000177169	ULK1	100	88.899	ENSRNOG00000037505	Ulk1	100	89.089	Rattus_norvegicus
ENSG00000177169	ULK1	100	97.333	ENSRBIG00000042231	ULK1	100	97.333	Rhinopithecus_bieti
ENSG00000177169	ULK1	99	77.996	ENSSHAG00000013399	ULK1	99	77.715	Sarcophilus_harrisii
ENSG00000177169	ULK1	100	90.246	ENSSSCG00000009742	ULK1	100	90.720	Sus_scrofa
ENSG00000177169	ULK1	93	68.844	ENSXETG00000002028	ulk1	99	69.447	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000045	autophagosome assembly	21873635.	IBA	Process
GO:0000407	phagophore assembly site	21873635.	IBA	Component
GO:0004674	protein serine/threonine kinase activity	21873635.	IBA	Function
GO:0004674	protein serine/threonine kinase activity	18936157.25126726.27103069.	IDA	Function
GO:0004674	protein serine/threonine kinase activity	9693035.	NAS	Function
GO:0004674	protein serine/threonine kinase activity	-	TAS	Function
GO:0005515	protein binding	11146101.17389358.18936157.19211835.19597335.20562859.21072212.22354037.22613832.23392225.23524951.24290141.24603492.25126726.25127057.25438055.25686248.25891078.26347139.26593251.27334615.28195531.28561066.29950492.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005737	cytoplasm	9693035.	NAS	Component
GO:0005741	mitochondrial outer membrane	-	TAS	Component
GO:0005776	autophagosome	17595159.22456507.	IDA	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	11146101.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006468	protein phosphorylation	9693035.	NAS	Process
GO:0006914	autophagy	18936157.	IDA	Process
GO:0006914	autophagy	17595159.	IMP	Process
GO:0006914	autophagy	-	ISS	Process
GO:0007165	signal transduction	-	IEA	Process
GO:0008104	protein localization	16940348.	IMP	Process
GO:0010506	regulation of autophagy	21873635.	IBA	Process
GO:0016020	membrane	21873635.	IBA	Component
GO:0016236	macroautophagy	22354037.	IMP	Process
GO:0016236	macroautophagy	-	TAS	Process
GO:0016241	regulation of macroautophagy	-	TAS	Process
GO:0016301	kinase activity	-	TAS	Function
GO:0017137	Rab GTPase binding	22613832.	IPI	Function
GO:0018105	peptidyl-serine phosphorylation	25126726.27103069.	IDA	Process
GO:0018107	peptidyl-threonine phosphorylation	27103069.	IDA	Process
GO:0030424	axon	-	IEA	Component
GO:0031102	neuron projection regeneration	-	IEA	Process
GO:0031175	neuron projection development	18007665.	IMP	Process
GO:0031333	negative regulation of protein complex assembly	25126726.	IDA	Process
GO:0031669	cellular response to nutrient levels	-	ISS	Process
GO:0032045	guanyl-nucleotide exchange factor complex	27103069.	IDA	Component
GO:0034045	phagophore assembly site membrane	18936157.	IDA	Component
GO:0042594	response to starvation	-	ISS	Process
GO:0042802	identical protein binding	20562859.23524951.	IPI	Function
GO:0044877	protein-containing complex binding	19211835.	IPI	Function
GO:0046777	protein autophosphorylation	21873635.	IBA	Process
GO:0046777	protein autophosphorylation	18936157.	IDA	Process
GO:0048675	axon extension	21873635.	IBA	Process
GO:0051020	GTPase binding	25891078.	IPI	Function
GO:0055037	recycling endosome	-	TAS	Component
GO:0075044	autophagy of host cells involved in interaction with symbiont	28389568.	IGI	Process
GO:0097629	extrinsic component of omegasome membrane	22885598.	IDA	Component
GO:0097632	extrinsic component of phagophore assembly site membrane	22885598.	IDA	Component
GO:0097635	extrinsic component of autophagosome membrane	22885598.	IDA	Component
GO:1990316	Atg1/ULK1 kinase complex	19211835.	IPI	Component
GO:2000786	positive regulation of autophagosome assembly	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.