EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
23770857Cavin-1 is essential for the tumor-promoting effect of caveolin-1 and enhances its prognostic potency in pancreatic cancer.Oncogene2014 May 22Liu Ldoi: 10.1038/onc.2013.223
21913217Down-regulation of the cavin family proteins in breast cancer.J Cell Biochem2012 JanBai Ldoi: 10.1002/jcb.23358.
27894957DNA methylation profiling identifies PTRF/Cavin-1 as a novel tumor suppressor in Ewing sarcoma when co-expressed with caveolin-1.Cancer Lett2017 Feb 1Huertas-Mart??nez Jdoi: 10.1016/j.canlet.2016.11.020
27203393PTRF suppresses the progression of colorectal cancers.Oncotarget2017 Jul 25Wang Fdoi: 10.18632/oncotarget.9424.
27634346MicroRNA187 is an independent prognostic factor in lung cancer and promotes lung cancer cell invasion via targeting of PTRF.Oncol Rep2016 NovPeng Jdoi: 10.3892/or.2016.5083
25942420Galectin-3 Overrides PTRF/Cavin-1 Reduction of PC3 Prostate Cancer Cell Migration.PLoS One2015 May 5Meng Fdoi: 10.1371/journal.pone.0126056
23404184Caveolin-1 and polymerase I and transcript release factor: new players in insulin-like growth factor-I receptor signaling.J Endocrinol Invest2013 MarHamoudane Mdoi: 10.3275/8848
23214712PTRF/cavin-1 is essential for multidrug resistance in cancer cells.J Proteome Res2013 Feb 1Yi JSdoi: 10.1021/pr300651m
22461895PTRF/cavin-1 and MIF proteins are identified as non-small cell lung cancer biomarkers by label-free proteomics.PLoS One2012G??mez-Pozo Adoi: 10.1371/journal.pone.0033752
23938946Caveola-forming proteins caveolin-1 and PTRF in prostate cancer.Nat Rev Urol2013 SepNassar ZDdoi: 10.1038/nrurol.2013.168
23934189PTRF/cavin-1 neutralizes non-caveolar caveolin-1 microdomains in prostate cancer.Oncogene2014 Jul 3Moon Hdoi: 10.1038/onc.2013.315
28393200MicroRNA-187 modulates epithelial-mesenchymal transition by targeting PTRF in non-small cell lung cancer.Oncol Rep2017 MayCai Ydoi: 10.3892/or.2017.5548

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1742422920Missense_MutationnovelK60E0.93
BLCAchr1742423070Missense_Mutationrs560641597E10Q0.27
BLCAchr1742405060Missense_MutationNAR267Q0.64
BLCAchr1742422792SilentnovelT102T0.53
BLCAchr1742404815Missense_MutationnovelD349N0.13
BLCAchr1742404776Missense_MutationnovelR362W0.57
BLCAchr1742404872Missense_MutationNAE330K0.22
BLCAchr1742404874Missense_MutationNAR329H0.25
BLCAchr1742404921Silentrs780026361T313T0.28
BRCAchr1742405063Missense_MutationNAT266M0.13
BRCAchr1742404800Missense_MutationNAE354Q0.4
BRCAchr1742404885SilentNAV325V0.29
BRCAchr1742405196Nonsense_MutationNAK222*0.37
BRCAchr1742422994Missense_MutationNAP35L0.48
CESCchr1742405022Missense_MutationnovelR280C0.37
CESCchr17424034803'UTRnovel0.21
CESCchr1742404918SilentNAA314A0.49
CESCchr1742404919Missense_MutationnovelA314V0.17
COADchr1742404985Missense_MutationNAT292M0.13
COADchr1742405330Missense_MutationNAA177V0.22
COADchr1742405096Missense_MutationNAT255M0.23
COADchr1742405298Missense_MutationNAE188K0.37
COADchr1742405208Missense_MutationNAA218T0.37
COADchr1742405335SilentnovelS175S0.31
COADchr1742404786SilentNAA358A0.15
COADchr1742405274Missense_MutationnovelA196T0.38
COADchr17424046783'UTRnovel0.47
COADchr1742422986Frame_Shift_DelNAA38Pfs*60.21
COADchr1742422917Missense_MutationNAI61F0.34
COADchr1742405094Missense_MutationNAR256C0.25
COADchr1742405354Missense_MutationNAS169N0.33
ESCAchr1742405020SilentnovelR280R0.22
ESCAchr1742422655Missense_MutationnovelR148H0.42
ESCAchr1742405251SilentnovelS203S0.38
GBMchr1742404838Missense_MutationnovelM341K0.42
HNSCchr1742405176SilentnovelR228R0.18
HNSCchr1742405346SilentnovelL172L0.11
HNSCchr1742404762SilentnovelS366S0.25
KIRPchr1742405341Missense_MutationNAK173N0.2
LAMLchr1742422640Missense_MutationnovelV153G1
LGGchr1742405022Missense_MutationnovelR280C0.33
LIHCchr1742422743Missense_Mutationrs758025496V119I0.28
LIHCchr1742422838Missense_MutationNAQ87L0.27
LIHCchr1742404887Missense_MutationNAV325I0.35
LIHCchr1742422991Nonsense_MutationnovelS36*0.43
LIHCchr1742404967Missense_Mutationrs144331065R298H0.11
LUADchr1742404888SilentnovelH324H0.16
LUADchr1742404872Missense_MutationNAE330K0.04
LUADchr1742405180Missense_MutationNAR227L0.22
LUSCchr1742422748Missense_MutationNAV117D0.33
LUSCchr1742404954SilentNAT302T0.18
LUSCchr1742404775Missense_MutationnovelR362P0.32
LUSCchr1742404900Silentrs746135739P320P0.1
OVchr1742422868Missense_MutationNAE77V0.67
PAADchr1742405335SilentnovelS175S0.33
PAADchr1742405061Missense_MutationNAR267W0.18
PAADchr1742405248SilentNAD204D0.2
PRADchr1742405254SilentnovelS202S0.07
PRADchr1742405021Missense_MutationnovelR280H0.41
READchr1742404873Silentrs754999996R329R0.27
READchr1742405001Missense_MutationNAR287C0.35
SARCchr1742404879Missense_MutationnovelK327N0.46
SKCMchr1742422728Missense_MutationNAV124M0.5
SKCMchr1742404786SilentNAA358A0.33
SKCMchr1742405317SilentnovelK181K0.28
SKCMchr1742405255Missense_MutationNAS202L0.44
SKCMchr1742422853Missense_MutationnovelM82K0.45
SKCMchr1742405286Missense_MutationnovelP192S0.46
SKCMchr17424046793'UTRnovel0.5
SKCMchr1742405255Missense_MutationNAS202L0.48
SKCMchr1742405286Missense_MutationNAP192T0.39
SKCMchr1742405255Missense_MutationNAS202L0.76
STADchr1742405251SilentnovelS203S0.19
STADchr1742423013Missense_MutationNAA29T0.29
STADchr1742404875Missense_Mutationrs752558303R329C0.35
STADchr1742404819SilentNAD347D0.24
STADchr1742405187Missense_MutationNAG225S0.18
STADchr1742405154Missense_MutationnovelF236L0.09
STADchr1742423009Missense_MutationNAQ30R0.16
STADchr1742405212SilentnovelS216S0.38
STADchr1742405063Missense_MutationNAT266M0.3
STADchr1742405202Missense_MutationNAR220C0.26
STADchr1742405210Missense_MutationnovelR217H0.12
STADchr1742404934Missense_MutationnovelA309V0.18
UCECchr1742405192Missense_MutationNAR223H0.31
UCECchr17424046463'UTRnovel0.39
UCECchr1742422669SilentnovelA143A0.11
UCECchr1742405283Missense_MutationnovelE193K0.08
UCECchr1742405293SilentnovelG189G0.38
UCECchr1742422791Missense_MutationnovelT103A0.18
UCECchr1742405094Missense_MutationNAR256C0.38
UCECchr17424035403'UTRnovel0.37
UCECchr1742405114Missense_MutationnovelR249H0.48
UCECchr17424036283'UTRnovel0.36
UCECchr1742422845Missense_Mutationrs61729284A85S0.21
UCECchr1742404979Missense_MutationNAR294Q0.31
UCECchr1742405084Missense_MutationnovelT259I0.28
UCECchr17424036283'UTRnovel0.15
UCECchr1742422796Missense_MutationnovelA101V0.41
UCECchr1742404985Missense_MutationNAT292M0.38
UCECchr1742404932Missense_MutationNAR310C0.47
UCECchr1742422919Missense_MutationNAK60T0.43
UCECchr1742405093Missense_Mutationrs775121102R256H0.23
UCECchr1742405209SilentnovelR217R0.45
UCECchr1742405347SilentNAS171S0.24
UCECchr1742422923Missense_MutationnovelD59N0.36
UCECchr1742405299SilentnovelG187G0.42
UCSchr1742404776Missense_MutationnovelR362W0.07
UCSchr1742405044SilentnovelK272K0.49

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.26670.0017784
BRCADEL0.29544.8302e-10
DLBCDEL00.18166
THCADEL0.0020.221
UCECDEL0.20045.8317e-06
UCSDEL0.42860.19877
UVMDEL0.03750.22482

Survival Analysis
CancerP-value Q-value
STAD0.012

Kaplan-Meier Survival Analysis

SARC0.0028

Kaplan-Meier Survival Analysis

MESO0.0034

Kaplan-Meier Survival Analysis

HNSC0.013

Kaplan-Meier Survival Analysis

LUSC0.019

Kaplan-Meier Survival Analysis

ESCA0.03

Kaplan-Meier Survival Analysis

COAD0.023

Kaplan-Meier Survival Analysis

BLCA0.0014

Kaplan-Meier Survival Analysis

READ0.026

Kaplan-Meier Survival Analysis

GBM0.00013

Kaplan-Meier Survival Analysis

THCA0.0045

Kaplan-Meier Survival Analysis

OV0.0065

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000177469 (Gene tree)
Gene ID
284119
Gene Symbol
CAVIN1
Alias
cavin-1|CGL4|PTRF
Full Name
caveolae associated protein 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Minus strand
Length
21,069 bases
Position
chr17:42,402,449-42,423,517
Accession
9688
RBP type
non-canonical RBP
Summary
This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy. [provided by RefSeq, Nov 2009]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000357037CAVIN1-2013828-ENSP00000349541390 (aa)-Q6NZI2
Gene Model
Click here to download ENSG00000177469's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000177469Platelet Function Tests7.8616571E-006-
ENSG00000177469Psoriasis6E-725903422
ENSG00000177469Crohn Disease3E-821102463
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000177469rs118718011742418754ACrohn's disease21102463[1.10-1.21]1.15EFO_0000384
ENSG00000177469rs9639861742409561CPsoriasis231435941.15EFO_0000676
ENSG00000177469rs80688441742419266?Eczema30595370HP_0000964
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000177469's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000177469CAVIN18141.945ENSMUSG00000045954Cavin27338.375Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding22658674.HDAFunction
GO:0005515protein binding17026959.19525939.24013648.24567387.IPIFunction
GO:0005634nucleus15242332.IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005737cytoplasm17026959.IDAComponent
GO:0005739mitochondrion15242332.IDAComponent
GO:0005783endoplasmic reticulum-IEAComponent
GO:0005829cytosol-IEAComponent
GO:0005886plasma membrane-IDAComponent
GO:0005901caveola21873635.IBAComponent
GO:0005901caveola17026959.19525939.24013648.IDAComponent
GO:0006361transcription initiation from RNA polymerase I promoter9582279.IDAProcess
GO:0006363termination of RNA polymerase I transcription9582279.IDAProcess
GO:0006363termination of RNA polymerase I transcription-TASProcess
GO:0009303rRNA transcription-ISSProcess
GO:0009306protein secretion-IEAProcess
GO:0032991protein-containing complex24013648.IDAComponent
GO:0042134rRNA primary transcript binding9582279.IDAFunction
GO:0042802identical protein binding24013648.IPIFunction
GO:0043231intracellular membrane-bounded organelle-IDAComponent
GO:0045121membrane raft25204797.IDAComponent
GO:2000147positive regulation of cell motility-ISSProcess
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us