EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26527749	Flightless I Homolog Represses Prostate Cancer Progression through Targeting Androgen Receptor Signaling.	Clin Cancer Res	2016 Mar 15	Wang T	doi: 10.1158/1078-0432.CCR-15-1632
26497552	Cytoskeletal protein Flightless I inhibits apoptosis, enhances tumor cell invasion and promotes cutaneous squamous cell carcinoma progression.	Oncotarget	2015 Nov 3	Kopecki Z	doi: 10.18632/oncotarget.5536.
24055811	Flightless I homolog negatively regulates ChREBP activity in cancer cells.	Int J Biochem Cell Biol	2013 Nov	Wu L	doi: 10.1016/j.biocel.2013.09.004

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr17	18245366	Silent	novel	L1221L	0.44
BLCA	chr17	18247745	Missense_Mutation	novel	A800V	0.28
BLCA	chr17	18252060	Silent	rs145214604	S395S	0.49
BLCA	chr17	18250891	Missense_Mutation	novel	E575Q	0.38
BLCA	chr17	18253646	Silent	novel	L251L	0.69
BLCA	chr17	18255222	Silent	novel	V96V	0.34
BLCA	chr17	18247243	Missense_Mutation	novel	E868Q	0.42
BLCA	chr17	18247226	Missense_Mutation	novel	M873I	0.35
BRCA	chr17	18251726	Missense_Mutation	NA	L446R	0.31
BRCA	chr17	18245993	Missense_Mutation	rs201173622	E1113K	0.14
BRCA	chr17	18251785	Silent	novel	R426R	0.32
BRCA	chr17	18254092	Silent	NA	L222L	0.5
BRCA	chr17	18245602	Missense_Mutation	NA	D1188H	0.27
BRCA	chr17	18246397	Silent	NA	I1039I	0.2
BRCA	chr17	18245779	Silent	rs144013061	D1156D	0.31
BRCA	chr17	18246010	Missense_Mutation	rs372274459	R1107Q	0.43
BRCA	chr17	18246456	Missense_Mutation	rs768015316	R1020C	0.64
BRCA	chr17	18254582	Missense_Mutation	rs760459503	R172C	0.42
CESC	chr17	18256923	Missense_Mutation	rs771487713	A54T	0.22
CESC	chr17	18247327	Missense_Mutation	NA	D840N	0.29
CESC	chr17	18254165	Missense_Mutation	rs765362239	T198M	0.07
CESC	chr17	18255250	Missense_Mutation	rs756056693	R87Q	0.42
COAD	chr17	18245772	Missense_Mutation	rs200966684	E1159K	0.31
COAD	chr17	18253654	Missense_Mutation	rs773795422	R249C	0.39
COAD	chr17	18245191	Missense_Mutation	rs185087719	A1253T	0.36
COAD	chr17	18245555	Missense_Mutation	novel	E1203D	0.23
COAD	chr17	18247746	Missense_Mutation	NA	A800T	0.29
COAD	chr17	18249178	Frame_Shift_Del	novel	*K628Rfs27**	0.37
COAD	chr17	18256942	Silent	NA	Y47Y	0.33
COAD	chr17	18245226	Missense_Mutation	rs374452292	R1241Q	0.41
COAD	chr17	18246428	Missense_Mutation	novel	K1029R	0.34
COAD	chr17	18246445	Missense_Mutation	novel	Q1023H	0.22
COAD	chr17	18254585	Missense_Mutation	novel	R171C	0.13
COAD	chr17	18251768	Missense_Mutation	novel	R432K	0.28
COAD	chr17	18251454	Frame_Shift_Del	novel	*S470Afs32**	0.36
COAD	chr17	18244904	3'UTR	novel		0.36
COAD	chr17	18251772	Missense_Mutation	novel	R431W	0.25
COAD	chr17	18246627	Missense_Mutation	NA	K1006N	0.4
COAD	chr17	18247292	Silent	NA	E851E	0.28
COAD	chr17	18254563	Missense_Mutation	rs140059134	T178M	0.44
COAD	chr17	18251291	Missense_Mutation	NA	E524K	0.2
ESCA	chr17	18246788	Missense_Mutation	novel	E953Q	0.15
ESCA	chr17	18246753	Silent	NA	G964G	0.4
GBM	chr17	18246219	Silent	novel	C1070C	0.09
GBM	chr17	18246784	Missense_Mutation	novel	D954G	0.41
GBM	chr17	18252472	Missense_Mutation	NA	E366D	0.29
GBM	chr17	18252482	Missense_Mutation	novel	T363R	0.15
GBM	chr17	18252476	Missense_Mutation	novel	I365T	0.1
HNSC	chr17	18252034	Missense_Mutation	NA	G404V	0.17
HNSC	chr17	18253429	Silent	novel	K295K	0.31
HNSC	chr17	18252036	Silent	novel	A403A	0.33
HNSC	chr17	18253658	Silent	novel	S247S	0.11
HNSC	chr17	18247947	Silent	rs770659287	L759L	0.3
HNSC	chr17	18253313	Missense_Mutation	novel	E334G	0.26
HNSC	chr17	18252501	Missense_Mutation	novel	E357K	0.09
HNSC	chr17	18256958	Missense_Mutation	novel	R42L	0.26
KICH	chr17	18245035	3'UTR	novel		1
KIRC	chr17	18247308	Missense_Mutation	novel	Y846S	0.37
KIRP	chr17	18256916	Missense_Mutation	novel	Q56R	0.32
KIRP	chr17	18246621	Silent	NA	F1008F	0.24
KIRP	chr17	18246700	Missense_Mutation	NA	C982Y	0.27
KIRP	chr17	18247341	Missense_Mutation	NA	F835C	0.16
KIRP	chr17	18247936	Missense_Mutation	novel	M763T	0.51
LGG	chr17	18249151	Frame_Shift_Ins	novel	*L637Hfs44**	0.07
LGG	chr17	18253303	Splice_Region	novel	C337C	0.33
LIHC	chr17	18250974	Missense_Mutation	NA	Y547C	0.1
LUAD	chr17	18252097	Missense_Mutation	NA	A383G	0.27
LUAD	chr17	18252482	Missense_Mutation	rs774800032	T363M	0.16
LUAD	chr17	18248568	Silent	rs563059948	P724P	0.33
LUAD	chr17	18254812	Missense_Mutation	novel	E124K	0.1
LUAD	chr17	18252481	Silent	rs148245851	T363T	0.19
LUAD	chr17	18247041	Silent	rs762877217	L896L	0.08
LUAD	chr17	18247290	Missense_Mutation	novel	A852G	0.17
LUAD	chr17	18247052	Missense_Mutation	NA	A893P	0.16
LUSC	chr17	18245396	Missense_Mutation	NA	Q1211H	0.09
LUSC	chr17	18245165	Missense_Mutation	NA	W1261C	0.19
LUSC	chr17	18245590	Missense_Mutation	NA	D1192N	0.18
LUSC	chr17	18254126	Missense_Mutation	novel	T211I	0.36
LUSC	chr17	18247705	Silent	novel	R813R	0.18
LUSC	chr17	18251271	Silent	novel	V530V	0.14
LUSC	chr17	18248831	Frame_Shift_Del	novel	*Q663Rfs4**	0.24
LUSC	chr17	18247955	Missense_Mutation	novel	V757L	0.23
LUSC	chr17	18247956	Missense_Mutation	novel	K756N	0.24
LUSC	chr17	18246397	Silent	NA	I1039I	0.13
LUSC	chr17	18248633	Frame_Shift_Del	novel	*P700Gfs9**	0.35
LUSC	chr17	18255225	Silent	novel	G95G	0.45
OV	chr17	18247214	Silent	rs754732453	L877L	0.32
OV	chr17	18247246	Missense_Mutation	novel	A867P	0.29
OV	chr17	18248638	Missense_Mutation	novel	E701A	0.07
OV	chr17	18251458	Missense_Mutation	NA	A468V	0.81
PAAD	chr17	18246386	Missense_Mutation	novel	G1043D	0.18
PAAD	chr17	18246934	Missense_Mutation	novel	D932G	0.1
PCPG	chr17	18247262	Silent	novel	G861G	0.29
PRAD	chr17	18248558	Missense_Mutation	NA	L728V	0.1
READ	chr17	18246428	Missense_Mutation	novel	K1029R	0.09
READ	chr17	18245772	Missense_Mutation	rs200966684	E1159K	0.85
READ	chr17	18251743	Missense_Mutation	NA	D440E	0.21
SARC	chr17	18254611	Missense_Mutation	rs755561718	R162H	0.77
SKCM	chr17	18247676	Missense_Mutation	NA	L823P	0.37
SKCM	chr17	18253384	Silent	NA	P310P	0.14
SKCM	chr17	18252492	Missense_Mutation	NA	H360Y	0.08
SKCM	chr17	18256960	Silent	NA	N41N	0.26
SKCM	chr17	18251015	Splice_Region	NA	T533T	0.42
SKCM	chr17	18245249	Silent	NA	S1233S	0.43
SKCM	chr17	18246379	Silent	novel	R1045R	0.42
SKCM	chr17	18247759	Silent	NA	L795L	0.49
SKCM	chr17	18246642	Silent	NA	T1001T	0.5
SKCM	chr17	18247268	Silent	NA	L859L	0.27
SKCM	chr17	18245754	Frame_Shift_Del	novel	*T1164Vfs14**	0.57
SKCM	chr17	18253348	Silent	NA	F322F	0.23
STAD	chr17	18252037	Missense_Mutation	rs775990658	A403V	0.21
STAD	chr17	18245150	Missense_Mutation	NA	K1266N	0.09
STAD	chr17	18247740	Missense_Mutation	NA	K802E	0.27
STAD	chr17	18251462	Missense_Mutation	NA	R467G	0.35
STAD	chr17	18247203	Frame_Shift_Del	novel	*F881Sfs16**	0.23
STAD	chr17	18251288	Missense_Mutation	NA	A525T	0.51
STAD	chr17	18254833	Missense_Mutation	novel	T117A	0.24
STAD	chr17	18245230	Missense_Mutation	rs563225941	R1240C	0.34
STAD	chr17	18253377	Missense_Mutation	novel	I313V	0.17
STAD	chr17	18245661	Splice_Site	NA	X1168_splice	0.25
STAD	chr17	18251330	Missense_Mutation	NA	P511S	0.26
STAD	chr17	18253454	Missense_Mutation	NA	A287V	0.21
STAD	chr17	18245192	Silent	rs547009769	H1252H	0.22
STAD	chr17	18244990	3'UTR	novel		0.23
TGCT	chr17	18246927	Silent	novel	Y934Y	0.08
THCA	chr17	18246002	Missense_Mutation	NA	D1110N	0.35
THCA	chr17	18247238	Missense_Mutation	NA	K869N	0.12
THCA	chr17	18253673	Frame_Shift_Ins	novel	*Y243Qfs66**	0.06
THCA	chr17	18246999	Silent	novel	F910F	0.1
THCA	chr17	18245003	3'UTR	novel		0.26
UCEC	chr17	18253622	Silent	rs555496794	T259T	0.36
UCEC	chr17	18246930	Silent	novel	C933C	0.34
UCEC	chr17	18251744	Missense_Mutation	novel	D440G	0.23
UCEC	chr17	18250920	Missense_Mutation	novel	A565V	0.07
UCEC	chr17	18254619	Silent	rs549259584	S159S	0.44
UCEC	chr17	18252516	Missense_Mutation	novel	L352M	0.39
UCEC	chr17	18254141	Missense_Mutation	novel	R206L	0.4
UCEC	chr17	18247794	Missense_Mutation	rs202126232	V784M	0.4
UCEC	chr17	18247753	Silent	novel	R797R	0.46
UCEC	chr17	18245794	Silent	novel	Q1151Q	0.04
UCEC	chr17	18247968	Missense_Mutation	novel	K752N	0.06
UCEC	chr17	18253618	Missense_Mutation	novel	L261M	0.06
UCEC	chr17	18256563	Missense_Mutation	rs143532166	T70M	0.16
UCEC	chr17	18248656	Missense_Mutation	rs148086852	Q695R	0.5
UCEC	chr17	18245357	Silent	rs368156305	C1224C	0.3
UCEC	chr17	18247780	Silent	rs760594872	L788L	0.4
UCEC	chr17	18245192	Silent	rs547009769	H1252H	0.19
UCEC	chr17	18250921	Missense_Mutation	rs763345256	A565T	0.48
UCEC	chr17	18248689	Missense_Mutation	rs374054347	R684Q	0.41
UCEC	chr17	18245808	Missense_Mutation	novel	G1147C	0.3
UCEC	chr17	18247015	Missense_Mutation	novel	D905G	0.29
UCEC	chr17	18251000	Silent	rs368249002	S538S	0.33
UCEC	chr17	18252061	Missense_Mutation	novel	S395L	0.47
UCEC	chr17	18252482	Missense_Mutation	rs774800032	T363M	0.3
UCEC	chr17	18256566	Missense_Mutation	novel	T69I	0.36
UCEC	chr17	18257044	Intron	novel		0.32
UCEC	chr17	18246805	Missense_Mutation	NA	E947A	0.31
UCEC	chr17	18253358	Missense_Mutation	novel	L319P	0.37
UCEC	chr17	18246798	Missense_Mutation	novel	E949D	0.5
UCEC	chr17	18246606	Silent	novel	P1013P	0.09
UCEC	chr17	18245779	Silent	rs144013061	D1156D	0.38
UCEC	chr17	18251378	Frame_Shift_Del	NA	*V495Wfs7**	0.17
UCEC	chr17	18245093	3'UTR	novel		0.36
UCEC	chr17	18255258	Silent	rs778729733	I84I	0.15
UCEC	chr17	18244987	3'UTR	novel		0.25
UCEC	chr17	18244927	3'UTR	novel		0.37
UCEC	chr17	18248652	Silent	novel	G696G	0.61
UCEC	chr17	18254582	Missense_Mutation	rs760459503	R172C	0.33
UCEC	chr17	18244857	3'UTR	novel		0.23
UCEC	chr17	18251000	Silent	rs368249002	S538S	0.51
UCEC	chr17	18245608	Frame_Shift_Del	novel	*F1185Lfs4**	0.06
UCEC	chr17	18250922	Silent	rs61738420	H564H	0.35
UCEC	chr17	18252036	Silent	novel	A403A	0.51
UCEC	chr17	18245779	Silent	rs144013061	D1156D	0.48
UCEC	chr17	18253940	Intron	novel		0.39
UCEC	chr17	18245221	Missense_Mutation	rs759682057	R1243C	0.42
UCEC	chr17	18247356	Missense_Mutation	novel	V830A	0.17
UCEC	chr17	18254115	Missense_Mutation	novel	L215M	0.28
UCEC	chr17	18245774	Missense_Mutation	rs754279330	A1158V	0.25
UCEC	chr17	18244974	3'UTR	novel		0.19
UCEC	chr17	18246973	Missense_Mutation	NA	R919Q	0.22
UCEC	chr17	18247267	Missense_Mutation	novel	S860T	0.21
UCEC	chr17	18256553	Silent	novel	G73G	0.24
UCEC	chr17	18245235	Missense_Mutation	rs201912251	R1238Q	0.62
UCEC	chr17	18246792	Missense_Mutation	NA	K951N	0.17
UCEC	chr17	18253393	Silent	novel	D307D	0.47
UCEC	chr17	18247794	Missense_Mutation	rs202126232	V784M	0.42
UCEC	chr17	18247958	Missense_Mutation	NA	K756E	0.22
UCEC	chr17	18257109	Intron	novel		0.41
UCEC	chr17	18247252	Missense_Mutation	rs750418958	R865C	0.33
UCEC	chr17	18244868	3'UTR	novel		0.16
UCEC	chr17	18257127	Intron	novel		0.33
UCEC	chr17	18253546	Missense_Mutation	novel	P285S	0.5
UCEC	chr17	18246926	Missense_Mutation	rs199804606	V935I	0.45
UCEC	chr17	18254563	Missense_Mutation	rs140059134	T178M	0.21
UCEC	chr17	18252044	Missense_Mutation	rs769100289	R401W	0.43
UCEC	chr17	18254647	Missense_Mutation	novel	L150R	0.38
UCEC	chr17	18256549	Silent	novel	L75L	0.27

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.125	0.18166
ESCA	DEL	0.3913	0.074408
READ	DEL	0.6545	0.077076
SARC	AMP	0.3735	8.4923e-19
THCA	DEL	0.014	0.221
UCEC	DEL	0.2245	0.00043918
UCS	DEL	0.5179	0.19877

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.024	Kaplan-Meier Survival Analysis
PRAD	0.018	Kaplan-Meier Survival Analysis
LUSC	0.0092	Kaplan-Meier Survival Analysis
ESCA	0.0058	Kaplan-Meier Survival Analysis
COAD	0.024	Kaplan-Meier Survival Analysis
CESC	0.05	Kaplan-Meier Survival Analysis
LAML	0.011	Kaplan-Meier Survival Analysis
UCEC	0.049	Kaplan-Meier Survival Analysis
GBM	0.004	Kaplan-Meier Survival Analysis
LIHC	0.0081	Kaplan-Meier Survival Analysis
OV	0.011	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000177731 (Gene tree)
Gene ID: 2314
Gene Symbol: FLII
Alias: FLI|FLIL|Fli1|MGC39265
Full Name: FLII actin remodeling protein
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 14,102 bases
Position: chr17:18,244,815-18,258,916
Accession: 3750
RBP type: non-canonical RBP
Summary: This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
10523836	Transforming activity of EWS/FLI is not strictly dependent upon DNA-binding activity.	Oncogene	1999 Sep 30	Jaishankar S	-
15273724	Role of protein-protein interactions in the antiapoptotic function of EWS-Fli-1.	Oncogene	2004 Sep 16	Ramakrishnan R	-
21872822	Promiscuous partnerships in Ewing's sarcoma.	Cancer Genet	2011 Jul	Sankar S	doi: 10.1016/j.cancergen.2011.07.008.
24632205	Flightless I (Drosophila) homolog facilitates chromatin accessibility of the estrogen receptor α target genes in MCF-7 breast cancer cells.	Biochem Biophys Res Commun	2014 Apr 4	Jeong KW	doi: 10.1016/j.bbrc.2014.03.011

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000327031	FLII-201	4338	XM_005256555	ENSP00000324573	1269 (aa)	XP_005256612	Q13045
ENST00000579294	FLII-222	3936	-	ENSP00000463534	1258 (aa)	-	Q13045
ENST00000584444	FLII-229	782	-	-	- (aa)	-	-
ENST00000577398	FLII-216	926	-	ENSP00000468045	207 (aa)	-	K7EQZ7
ENST00000577626	FLII-219	557	-	ENSP00000463902	117 (aa)	-	J3QQU5
ENST00000628188	FLII-230	156	-	ENSP00000486754	51 (aa)	-	J3KS39
ENST00000487369	FLII-208	522	-	-	- (aa)	-	-
ENST00000488932	FLII-211	838	-	ENSP00000463838	279 (aa)	-	J3QQQ2
ENST00000473425	FLII-205	585	-	ENSP00000467212	99 (aa)	-	K7EP37
ENST00000578101	FLII-220	4148	-	ENSP00000462293	51 (aa)	-	J3KS39
ENST00000580453	FLII-223	673	-	-	- (aa)	-	-
ENST00000578558	FLII-221	2377	-	ENSP00000462314	700 (aa)	-	J3KS54
ENST00000496727	FLII-214	792	-	-	- (aa)	-	-
ENST00000582626	FLII-228	573	-	-	- (aa)	-	-
ENST00000581858	FLII-227	644	-	ENSP00000465202	23 (aa)	-	K7EJJ7
ENST00000493600	FLII-213	656	-	-	- (aa)	-	-
ENST00000488221	FLII-210	859	-	-	- (aa)	-	-
ENST00000474265	FLII-206	596	-	-	- (aa)	-	-
ENST00000581349	FLII-225	582	-	ENSP00000467199	133 (aa)	-	K7EP27
ENST00000577402	FLII-217	689	-	-	- (aa)	-	-
ENST00000580966	FLII-224	514	-	-	- (aa)	-	-
ENST00000493401	FLII-212	458	-	-	- (aa)	-	-
ENST00000465046	FLII-204	699	-	-	- (aa)	-	-
ENST00000581401	FLII-226	385	-	ENSP00000462797	29 (aa)	-	J3KT47
ENST00000461110	FLII-203	1032	-	-	- (aa)	-	-
ENST00000478416	FLII-207	878	-	-	- (aa)	-	-
ENST00000459958	FLII-202	692	-	-	- (aa)	-	-
ENST00000577485	FLII-218	555	-	ENSP00000463675	185 (aa)	-	J3QLR6
ENST00000545457	FLII-215	3975	-	ENSP00000438536	1214 (aa)	-	Q13045
ENST00000487693	FLII-209	669	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000177731's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000177731	rs68165736	17	18253846	?	Hair color	30595370			EFO_0007822

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000177731's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003779	actin binding	9525888.	IDA	Function
GO:0005515	protein binding	9671805.10366446.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005815	microtubule organizing center	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005903	brush border	-	IEA	Component
GO:0005925	focal adhesion	-	IEA	Component
GO:0007275	multicellular organism development	-	IEA	Process
GO:0030036	actin cytoskeleton organization	-	IEA	Process
GO:0051014	actin filament severing	-	IEA	Process
GO:0051015	actin filament binding	-	IEA	Function

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.