EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
19597826	Identification of IMPDH2 as a tumor-associated antigen in colorectal cancer using immunoproteomics analysis.	Int J Colorectal Dis	2009 Nov	He Y	doi: 10.1007/s00384-009-0759-2
24659377	Enhanced expression of IMPDH2 promotes metastasis and advanced tumor progression in patients with prostate cancer.	Clin Transl Oncol	2014 Oct	Zhou L	doi: 10.1007/s12094-014-1167-9
25465060	Elevated expression of IMPDH2 is associated with progression of kidney and bladder cancer.	Med Oncol	2015 Jan	Zou J	doi: 10.1007/s12032-014-0373-1

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr3	49027790	Missense_Mutation	novel	G151R	0.29
BLCA	chr3	49026365	Missense_Mutation	rs754546292	R322Q	0.1
BLCA	chr3	49025154	Silent	rs183457824	A374A	0.55
BLCA	chr3	49026881	Silent	novel	L209L	0.13
BLCA	chr3	49026338	Missense_Mutation	novel	C331S	0.5
BLCA	chr3	49024973	Missense_Mutation	novel	I406M	0.46
BLCA	chr3	49024547	Missense_Mutation	novel	E491Q	0.33
BLCA	chr3	49026978	Missense_Mutation	novel	L201V	0.06
BLCA	chr3	49026834	Silent	novel	R224R	0.24
BLCA	chr3	49024801	Missense_Mutation	novel	E433K	0.43
BLCA	chr3	49025028	Missense_Mutation	NA	S388C	0.14
BRCA	chr3	49024908	Missense_Mutation	NA	N428S	0.44
BRCA	chr3	49029312	Silent	NA	V13V	0.19
BRCA	chr3	49024348	3'UTR	novel		0.14
BRCA	chr3	49027743	Silent	NA	L166L	0.4
CESC	chr3	49024971	Missense_Mutation	novel	R407Q	0.3
CESC	chr3	49026971	Missense_Mutation	rs761002300	R203H	0.4
CESC	chr3	49024534	Missense_Mutation	NA	S495F	0.23
COAD	chr3	49028493	Missense_Mutation	NA	T63A	0.17
COAD	chr3	49024955	Silent	NA	R412R	0.13
COAD	chr3	49028487	Silent	NA	L65L	0.35
COAD	chr3	49027821	Silent	rs530770243	C140C	0.28
COAD	chr3	49025215	Missense_Mutation	novel	A354V	0.42
COAD	chr3	49026521	Missense_Mutation	NA	N303I	0.4
COAD	chr3	49026972	Missense_Mutation	rs769004042	R203C	0.14
COAD	chr3	49028492	Missense_Mutation	NA	T63I	0.46
COAD	chr3	49026836	Missense_Mutation	rs377463111	R224W	0.09
ESCA	chr3	49027890	Missense_Mutation	novel	D117E	0.09
GBM	chr3	49024788	Missense_Mutation	novel	I437T	0.13
GBM	chr3	49029288	Silent	NA	Q21Q	0.46
GBM	chr3	49028758	Splice_Region	novel	V49V	0.1
GBM	chr3	49024379	3'UTR	novel		0.67
GBM	chr3	49028509	Missense_Mutation	novel	K57N	0.07
GBM	chr3	49027036	Missense_Mutation	novel	K181N	0.14
GBM	chr3	49024720	Silent	NA	L460L	0.08
GBM	chr3	49024354	3'UTR	novel		0.32
GBM	chr3	49028699	Intron	novel		0.22
GBM	chr3	49026843	Silent	NA	I221I	0.74
HNSC	chr3	49026561	In_Frame_Del	novel	K288_Y289del	0.82
HNSC	chr3	49026774	Silent	novel	L244L	0.74
HNSC	chr3	49024374	3'UTR	novel		0.1
HNSC	chr3	49024516	Missense_Mutation	novel	G501A	0.14
HNSC	chr3	49026843	Missense_Mutation	novel	I221M	0.08
KIRP	chr3	49027044	Missense_Mutation	novel	M179V	0.23
LGG	chr3	49027823	Missense_Mutation	NA	C140S	0.25
LUAD	chr3	49024957	Missense_Mutation	novel	R412S	0.08
LUAD	chr3	49025127	Splice_Region	novel	T383T	0.21
LUAD	chr3	49027765	Missense_Mutation	novel	S159F	0.16
LUSC	chr3	49026984	Missense_Mutation	novel	E199K	0.2
LUSC	chr3	49026866	Nonsense_Mutation	novel	E214*	0.17
LUSC	chr3	49027736	Missense_Mutation	rs779639948	E169K	0.48
OV	chr3	49024685	Silent	novel	I471I	0.05
OV	chr3	49024372	3'UTR	novel		0.31
OV	chr3	49024799	In_Frame_Ins	novel	A434_D435insHLIRA	0.06
OV	chr3	49026732	Silent	NA	Y258Y	0.27
PAAD	chr3	49025212	Missense_Mutation	novel	R355Q	0.26
PAAD	chr3	49027835	Missense_Mutation	novel	R136W	0.2
PRAD	chr3	49028315	Missense_Mutation	novel	G86D	0.15
PRAD	chr3	49024957	Missense_Mutation	rs779322486	R412C	0.27
READ	chr3	49028489	Frame_Shift_Del	NA	*P64Hfs17**	0.28
READ	chr3	49024944	Missense_Mutation	NA	S416Y	0.17
READ	chr3	49027036	Missense_Mutation	novel	K181N	0.44
READ	chr3	49028475	Missense_Mutation	novel	P69S	0.33
SARC	chr3	49026586	Missense_Mutation	novel	I281M	0.53
SKCM	chr3	49028503	Silent	NA	I59I	0.11
SKCM	chr3	49027725	Silent	NA	D172D	0.52
SKCM	chr3	49028790	Missense_Mutation	novel	P39S	0.33
SKCM	chr3	49029263	Missense_Mutation	NA	L30F	0.22
SKCM	chr3	49027719	Silent	NA	F174F	0.33
SKCM	chr3	49024406	Splice_Site	novel	X508_splice	0.41
SKCM	chr3	49028275	Silent	novel	F99F	0.16
STAD	chr3	49025155	Missense_Mutation	novel	A374V	0.14
STAD	chr3	49028712	Intron	novel		0.45
STAD	chr3	49024802	Splice_Region	NA	S432S	0.04
STAD	chr3	49028294	Missense_Mutation	NA	H93R	0.19
STAD	chr3	49028463	Frame_Shift_Ins	novel	*V73Qfs9**	0.23
STAD	chr3	49026332	Missense_Mutation	NA	T333M	0.13
STAD	chr3	49026332	Missense_Mutation	NA	T333M	0.3
STAD	chr3	49026994	Missense_Mutation	NA	K195N	0.05
STAD	chr3	49026815	Missense_Mutation	NA	R231W	0.29
THCA	chr3	49026590	Missense_Mutation	NA	S280C	0.07
THCA	chr3	49025213	Missense_Mutation	NA	R355W	0.1
UCEC	chr3	49028485	Silent	NA	L65L	0.22
UCEC	chr3	49024537	Missense_Mutation	rs757423578	T494M	0.35
UCEC	chr3	49024495	Missense_Mutation	rs750101189	S508L	0.19
UCEC	chr3	49027733	Nonsense_Mutation	NA	E170*	0.37
UCEC	chr3	49025211	Silent	NA	R355R	0.43
UCEC	chr3	49026853	Missense_Mutation	novel	L218P	0.29
UCEC	chr3	49026341	Missense_Mutation	NA	I330T	0.41
UCEC	chr3	49027862	Missense_Mutation	NA	V127M	0.11
UCEC	chr3	49028314	Silent	NA	G86G	0.22
UCEC	chr3	49029288	Silent	NA	Q21Q	0.17
UCEC	chr3	49024512	Silent	rs374837017	G502G	0.44
UCEC	chr3	49026696	Silent	rs771750284	V270V	0.34
UCEC	chr3	49024935	Missense_Mutation	novel	A419V	0.13
UCEC	chr3	49026835	Missense_Mutation	rs373752085	R224Q	0.45
UCEC	chr3	49024908	Missense_Mutation	NA	N428S	0.38
UCEC	chr3	49025181	Silent	novel	G365G	0.37
UCEC	chr3	49029260	Missense_Mutation	novel	T31A	0.11
UCEC	chr3	49024709	Silent	novel	G463G	0.44
UCEC	chr3	49026878	Missense_Mutation	novel	P210S	0.4
UCEC	chr3	49027915	Missense_Mutation	novel	K109R	0.23
UCEC	chr3	49029347	Missense_Mutation	novel	A2T	0.23
UCEC	chr3	49024680	Missense_Mutation	novel	A473V	0.4
UCEC	chr3	49026796	Missense_Mutation	novel	S237F	0.18
UCEC	chr3	49028270	Missense_Mutation	novel	A101D	0.26
UCEC	chr3	49024494	Splice_Site	rs748863433	X508_splice	0.17
UCEC	chr3	49025253	Silent	novel	R341R	0.07
UCEC	chr3	49025154	Silent	rs183457824	A374A	0.46
UCEC	chr3	49027764	Silent	novel	S159S	0.19
UCEC	chr3	49028522	Missense_Mutation	novel	S53Y	0.24
UCEC	chr3	49028719	Intron	novel		0.13
UCEC	chr3	49026984	Nonsense_Mutation	novel	E199*	0.33
UCEC	chr3	49026847	Missense_Mutation	novel	A220V	0.42
UCEC	chr3	49029301	Missense_Mutation	NA	G17E	0.35

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BRCA	DEL	0.2769	4.5968e-31
CHOL	DEL	0.8056	0.02241
DLBC	DEL	0.1667	0.016959
GBM	DEL	0.0745	0.056565
LGG	DEL	0.078	0.00089193
LUAD	DEL	0.343	0.0021265
PAAD	DEL	0.1848	0.030662
SARC	DEL	0.214	0.0034746
SKCM	DEL	0.1635	0.13887
TGCT	AMP	0.12	0.23596
TGCT	DEL	0.1933	0.08422
THYM	DEL	0.0813	0.037527

Survival Analysis

Cancer	P-value	Q-value
SARC	0.0035	Kaplan-Meier Survival Analysis
ACC	0.038	Kaplan-Meier Survival Analysis
SKCM	0.0023	Kaplan-Meier Survival Analysis
BRCA	0.022	Kaplan-Meier Survival Analysis
KICH	0.012	Kaplan-Meier Survival Analysis
GBM	0.011	Kaplan-Meier Survival Analysis
LIHC	0.00076	Kaplan-Meier Survival Analysis
DLBC	0.016	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
UVM	0.00063	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000178035 (Gene tree)
Gene ID: 3615
Gene Symbol: IMPDH2
Alias: N
Full Name: inosine monophosphate dehydrogenase 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 5,377 bases
Position: chr3:49,024,325-49,029,701
Accession: 6053
RBP type: non-canonical RBP
Summary: This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000466147	IMPDH2-206	691	-	-	- (aa)	-	-
ENST00000496837	IMPDH2-212	760	-	-	- (aa)	-	-
ENST00000484872	IMPDH2-209	643	-	-	- (aa)	-	-
ENST00000462980	IMPDH2-204	908	-	-	- (aa)	-	-
ENST00000472328	IMPDH2-207	469	-	-	- (aa)	-	-
ENST00000326739	IMPDH2-201	1643	XM_006713128	ENSP00000321584	514 (aa)	XP_006713191	P12268
ENST00000481274	IMPDH2-208	840	-	-	- (aa)	-	-
ENST00000442157	IMPDH2-203	865	-	ENSP00000403502	279 (aa)	-	E7ETK5
ENST00000463903	IMPDH2-205	420	-	-	- (aa)	-	-
ENST00000491610	IMPDH2-211	844	-	-	- (aa)	-	-
ENST00000429182	IMPDH2-202	1469	-	ENSP00000393525	470 (aa)	-	H0Y4R1
ENST00000485500	IMPDH2-210	852	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000178035's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00230	Purine metabolism	KEGG
hsa00983	Drug metabolism - other enzymes	KEGG
hsa01100	Metabolic pathways	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000178035	rs72624911	3	49027143	T	Educational attainment (years of education)	30038396	[0.022-0.035] unit increase	0.0282	EFO_0004784

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000178035's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000166	nucleotide binding	14766016.	IDA	Function
GO:0003677	DNA binding	-	IEA	Function
GO:0003723	RNA binding	-	IEA	Function
GO:0003938	IMP dehydrogenase activity	21873635.	IBA	Function
GO:0005515	protein binding	25416956.28985504.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005634	nucleus	14766016.	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	14766016.	IDA	Component
GO:0005778	peroxisomal membrane	21525035.	HDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006177	GMP biosynthetic process	-	IEA	Process
GO:0006183	GTP biosynthetic process	21873635.	IBA	Process
GO:0007623	circadian rhythm	28985504.	IDA	Process
GO:0009168	purine ribonucleoside monophosphate biosynthetic process	-	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0034774	secretory granule lumen	-	TAS	Component
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0046651	lymphocyte proliferation	-	IEA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0051289	protein homotetramerization	-	IEA	Process
GO:0055114	oxidation-reduction process	-	IEA	Process
GO:0060041	retina development in camera-type eye	-	IEA	Process
GO:0070062	extracellular exosome	20458337.	HDA	Component
GO:0071353	cellular response to interleukin-4	-	IEA	Process
GO:1904813	ficolin-1-rich granule lumen	-	TAS	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.