EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24146193	Specific expression of k63-linked ubiquitination of calmodulin-like protein 5 in breast cancer of premenopausal patients.	J Cancer Res Clin Oncol	2013 Dec	Debald M	doi: 10.1007/s00432-013-1541-y

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr10	5499533	5'UTR	novel		0.4
BLCA	chr10	5499126	Silent	rs368824145	R105R	0.18
BRCA	chr10	5499320	Missense_Mutation	NA	T40M	0.1
BRCA	chr10	5499336	Missense_Mutation	rs760863630	A35T	0.47
CESC	chr10	5499459	5'UTR	novel		0.24
COAD	chr10	5499546	5'UTR	novel		0.33
COAD	chr10	5499181	Silent	NA	A86A	0.48
COAD	chr10	5499168	Missense_Mutation	NA	D91N	0.29
COAD	chr10	5499252	Missense_Mutation	NA	E63K	0.14
ESCA	chr10	5499162	Missense_Mutation	novel	D93Y	0.29
GBM	chr10	5499021	Missense_Mutation	NA	A140T	0.83
GBM	chr10	5499216	Missense_Mutation	novel	K75Q	0.43
GBM	chr10	5499224	Missense_Mutation	rs199855788	A72V	0.64
GBM	chr10	5499223	Silent	NA	A72A	0.66
LAML	chr10	5499286	Silent	novel	K51K	0.05
LGG	chr10	5499232	Silent	NA	F69F	0.09
LGG	chr10	5499158	Missense_Mutation	novel	G94D	0.26
LUAD	chr10	5499283	Silent	novel	L52L	0.16
LUAD	chr10	5499364	Missense_Mutation	NA	N25K	0.12
LUAD	chr10	5499205	Silent	novel	A78A	0.16
LUSC	chr10	5499074	Missense_Mutation	NA	M122T	0.24
LUSC	chr10	5499111	Missense_Mutation	rs767115673	L110M	0.22
LUSC	chr10	5499265	Silent	novel	S58S	0.29
LUSC	chr10	5499141	Missense_Mutation	NA	V100L	0.15
OV	chr10	5499365	Missense_Mutation	NA	N25S	0.37
READ	chr10	5499252	Missense_Mutation	NA	E63K	0.33
READ	chr10	5499470	5'UTR	novel		0.46
SARC	chr10	5499432	Missense_Mutation	NA	G3S	1
SKCM	chr10	5499184	Silent	NA	V85V	0.29
SKCM	chr10	5499075	Missense_Mutation	NA	M122L	0.5
SKCM	chr10	5499232	Silent	NA	F69F	0.33
SKCM	chr10	5499046	Missense_Mutation	NA	D131E	0.27
SKCM	chr10	5499163	Silent	novel	Q92Q	0.29
SKCM	chr10	5499278	Missense_Mutation	NA	S54F	0.21
SKCM	chr10	5499252	Missense_Mutation	NA	E63K	0.56
SKCM	chr10	5499102	Missense_Mutation	NA	P113S	0.23
SKCM	chr10	5499362	Missense_Mutation	NA	G26D	0.39
SKCM	chr10	5499231	Silent	NA	L70L	0.43
SKCM	chr10	5499303	Missense_Mutation	NA	E46K	0.27
STAD	chr10	5499022	Missense_Mutation	NA	F139L	0.38
STAD	chr10	5499224	Missense_Mutation	rs199855788	A72V	0.55
STAD	chr10	5499066	Missense_Mutation	NA	E125K	0.43
STAD	chr10	5499262	Silent	NA	D59D	0.3
STAD	chr10	5499256	Silent	NA	D61D	0.21
UCEC	chr10	5499169	Silent	novel	F90F	0.26
UCEC	chr10	5499336	Missense_Mutation	rs760863630	A35T	0.11
UCEC	chr10	5499177	Missense_Mutation	novel	R88C	0.29
UCEC	chr10	5499106	Silent	novel	G111G	0.21
UCEC	chr10	5499517	5'UTR	novel		0.33
UCEC	chr10	5499224	Missense_Mutation	rs199855788	A72V	0.54
UCEC	chr10	5499325	Missense_Mutation	novel	K38N	0.3
UCEC	chr10	5499459	5'UTR	NA		0.36
UCEC	chr10	5498970	3'UTR	novel		0.47
UCEC	chr10	5498879	3'UTR	novel		0.42
UCEC	chr10	5499259	Silent	rs747649025	G60G	0.53
UCEC	chr10	5499226	Silent	NA	T71T	0.45
UCEC	chr10	5499313	Missense_Mutation	novel	K42N	0.43
UCEC	chr10	5499168	Missense_Mutation	NA	D91N	0.26
UCEC	chr10	5499174	Missense_Mutation	rs768112457	A89T	0.54

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1333	0.19593
BRCA	AMP	0.238	1.5549e-05
ESCA	DEL	0.1957	0.041463
KIRC	AMP	0.0208	0.17403
LGG	AMP	0.1189	1.9574e-05
MESO	DEL	0.3218	0.0040398
PAAD	DEL	0.1522	0.169
STAD	DEL	0.1043	0.13903
TGCT	DEL	0.44	0.055393

Survival Analysis

Cancer	P-value	Q-value
MESO	0.05	Kaplan-Meier Survival Analysis
UCS	0.017	Kaplan-Meier Survival Analysis
HNSC	0.0001	Kaplan-Meier Survival Analysis
SKCM	0.00011	Kaplan-Meier Survival Analysis
PAAD	0.029	Kaplan-Meier Survival Analysis
BLCA	0.022	Kaplan-Meier Survival Analysis
CESC	0.015	Kaplan-Meier Survival Analysis
LUAD	0.0098	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000178372 (Gene tree)
Gene ID: 51806
Gene Symbol: CALML5
Alias: CLSP
Full Name: calmodulin like 5
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 876 bases
Position: chr10:5,498,695-5,499,570
Accession: 18180
RBP type: non-canonical RBP
Summary: This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key enzyme in the terminal differentiation of keratinocytes. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000380332	CALML5-201	859	-	ENSP00000369689	146 (aa)	-	Q9NZT1

Gene Model

Click here to download ENSG00000178372's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04014	Ras signaling pathway	KEGG
hsa04015	Rap1 signaling pathway	KEGG
hsa04020	Calcium signaling pathway	KEGG
hsa04022	cGMP-PKG signaling pathway	KEGG
hsa04024	cAMP signaling pathway	KEGG
hsa04070	Phosphatidylinositol signaling system	KEGG
hsa04114	Oocyte meiosis	KEGG
hsa04218	Cellular senescence	KEGG
hsa04261	Adrenergic signaling in cardiomyocytes	KEGG
hsa04270	Vascular smooth muscle contraction	KEGG
hsa04371	Apelin signaling pathway	KEGG
hsa04625	C-type lectin receptor signaling pathway	KEGG
hsa04713	Circadian entrainment	KEGG
hsa04720	Long-term potentiation	KEGG
hsa04722	Neurotrophin signaling pathway	KEGG
hsa04728	Dopaminergic synapse	KEGG
hsa04740	Olfactory transduction	KEGG
hsa04744	Phototransduction	KEGG
hsa04750	Inflammatory mediator regulation of TRP channels	KEGG
hsa04910	Insulin signaling pathway	KEGG
hsa04912	GnRH signaling pathway	KEGG
hsa04915	Estrogen signaling pathway	KEGG
hsa04916	Melanogenesis	KEGG
hsa04921	Oxytocin signaling pathway	KEGG
hsa04922	Glucagon signaling pathway	KEGG
hsa04924	Renin secretion	KEGG
hsa04925	Aldosterone synthesis and secretion	KEGG
hsa04970	Salivary secretion	KEGG
hsa04971	Gastric acid secretion	KEGG
hsa05010	Alzheimer disease	KEGG
hsa05031	Amphetamine addiction	KEGG
hsa05034	Alcoholism	KEGG
hsa05133	Pertussis	KEGG
hsa05152	Tuberculosis	KEGG
hsa05163	Human cytomegalovirus infection	KEGG
hsa05167	Kaposi sarcoma-associated herpesvirus infection	KEGG
hsa05170	Human immunodeficiency virus 1 infection	KEGG
hsa05200	Pathways in cancer	KEGG
hsa05214	Glioma	KEGG
hsa05418	Fluid shear stress and atherosclerosis	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000178372's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005509	calcium ion binding	21873635.	IBA	Function
GO:0005509	calcium ion binding	-	IEA	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0007165	signal transduction	10777582.	TAS	Process
GO:0008544	epidermis development	10777582.	TAS	Process
GO:0019722	calcium-mediated signaling	21873635.	IBA	Process
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:1904813	ficolin-1-rich granule lumen	-	TAS	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.