EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
27829216ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human breast cancer.Oncotarget2016 Dec 13Strietz Jdoi: 10.18632/oncotarget.13086.
29311133Dual IRE1 RNase functions dictate glioblastoma development.EMBO Mol Med2018 MarLhomond Sdoi: 10.15252/emmm.201707929.
17638880IRE1 signaling is essential for ischemia-induced vascular endothelial growth factor-A expression and contributes to angiogenesis and tumor growth in vivo.Cancer Res2007 Jul 15Drogat B-
26742428Activation of IRE1α-XBP1 pathway induces cell proliferation and invasion in colorectal carcinoma.Biochem Biophys Res Commun2016 Jan 29Jin Cdoi: 10.1016/j.bbrc.2015.12.119
23363253Insulin receptor, IRS1, IRS2, INSIG1, INSIG2, RRAD, and BAIAP2 gene expressions in glioma U87 cells with ERN1 loss of function: effect of hypoxia and glutamine or glucose deprivation.Endocr Regul2013 JanMinchenko DO-
25816608Expression of phosphoribosyl pyrophosphate synthetase genes in U87 glioma cells with ERN1 knockdown: effect of hypoxia and endoplasmic reticulum stress.Ukr Biochem J2014 Nov-DecMinchenko OH-
28618969Penfluridol induces endoplasmic reticulum stress leading to autophagy in pancreatic cancer.Tumour Biol2017 JunRanjan Adoi: 10.1177/1010428317705517.
28167662Impairment of both IRE1 expression and XBP1 activation is a hallmark of GCB DLBCL and contributes to tumor growth.Blood2017 Apr 27Bujisic Bdoi: 10.1182/blood-2016-09-741348
29235329Expression of IGFBP6, IGFBP7, NOV, CYR61, WISP1 and WISP2 genes in U87 glioma cells in glutamine deprivation condition.Ukr Biochem J2016 May-JunMinchenko OHdoi: 10.15407/ubj88.03.066.
29537195Expression of proliferation related transcription factor genes in U87 glioma cells with IRE1 knockdown: upon glucose and glutamine deprivation.Fiziol Zh2016Tsymbal DO-
29263275Deficiency of the IRE1α-Autophagy Axis Enhances the Antitumor Effects of the Oncolytic Virus M1.J Virol2018 Feb 26Li Kdoi: 10.1128/JVI.01331-17
25870107Cleavage of BLOC1S1 mRNA by IRE1 Is Sequence Specific, Temporally Separate from XBP1 Splicing, and Dispensable for Cell Viability under Acute Endoplasmic Reticulum Stress.Mol Cell Biol2015 JunBright MDdoi: 10.1128/MCB.00013-15
26134873RITA enhances irradiation-induced apoptosis in p53-defective cervical cancer cells via upregulation of IRE1α/XBP1 signaling.Oncol Rep2015 SepZhu Hdoi: 10.3892/or.2015.4083
26517687A novel chemical, STF-083010, reverses tamoxifen-related drug resistance in breast cancer by inhibiting IRE1/XBP1.Oncotarget2015 Dec 1Ming Jdoi: 10.18632/oncotarget.5827.
24565834Modulation of endoplasmic reticulum (ER) stress-induced autophagy by C/EBP homologous protein (CHOP) and inositol-requiring enzyme 1α (IRE1α) in human colon cancer cells.Biochem Biophys Res Commun2014 Mar 7Shimodaira Ydoi: 10.1016/j.bbrc.2014.02.054
24970676Connecting endoplasmic reticulum stress to autophagy through IRE1/JNK/beclin-1 in breast cancer cells.Int J Mol Med2014 SepCheng Xdoi: 10.3892/ijmm.2014.1822
28358375Novel prosurvival function of Yip1A in human cervical cancer cells: constitutive activation of the IRE1 and PERK pathways of the unfolded protein response.Cell Death Dis2017 Mar 30Taguchi Ydoi: 10.1038/cddis.2017.147.
28128204A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1α stability.Nat Commun2017 Jan 27Liu Jdoi: 10.1038/ncomms14186.
30111846Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy.Nat Commun2018 Aug 15Logue SEdoi: 10.1038/s41467-018-05763-8.
30305738IRE1α-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity.Nature2018 OctSong Mdoi: 10.1038/s41586-018-0597-x

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1764063998Frame_Shift_DelnovelN357Gfs*30.16
BLCAchr1764054393Missense_MutationnovelE604K0.56
BLCAchr17640438563'UTRnovel0.44
BRCAchr1764045372SilentnovelV880V0.07
BRCAchr1764052925Missense_MutationNAG703D0.26
BRCAchr1764066782Missense_MutationNAN244S0.09
BRCAchr1764060562Silentrs752482120A371A0.32
BRCAchr1764053304Missense_Mutationrs372670758S674L0.18
BRCAchr1764052891SilentNAL714L0.47
BRCAchr1764052782Missense_MutationnovelP751T0.08
BRCAchr1764047919Missense_Mutationrs780870849A823V0.23
CESCchr1764047970Missense_Mutationrs775768349R806H0.15
CESCchr17640439093'UTRnovel0.45
CESCchr1764072066SilentNAL131L0.31
CESCchr1764075226Missense_MutationNAE102K0.31
CESCchr1764044886Missense_MutationnovelD899Y0.43Ribonuc_2-5A
CESCchr1764045406Missense_MutationnovelV869A0.5Ribonuc_2-5A
CESCchr1764052936SilentnovelP699P0.39
CESCchr1764044106Missense_Mutationrs200145771H939R0.43Ribonuc_2-5A
CESCchr1764044867Missense_MutationNAR905T0.43Ribonuc_2-5A
CHOLchr1764065272SilentnovelV286V0.38
COADchr1764047978SilentNAV803V0.32
COADchr1764065216Missense_MutationNAA305V0.31
COADchr1764047929Missense_MutationNAR820C0.33
COADchr1764052960SilentNAP691P0.21
COADchr1764066868Silentrs367596145D215D0.36
COADchr1764079698SilentNAL82L0.33
COADchr1764047940Missense_MutationnovelD816V0.05
COADchr1764064047SilentNAF342F0.43
COADchr1764079676Missense_MutationnovelN90D0.05
COADchr1764052818Missense_MutationnovelA739T0.05
COADchr1764072063Silentrs374999844T132T0.28
COADchr1764043997Silentrs368375095D975D0.26
COADchr1764055926In_Frame_InsNAQ473dup0.33
COADchr1764054314Missense_MutationNAC630Y0.19
COADchr1764044083Missense_MutationnovelA947P0.31Ribonuc_2-5A
DLBCchr1764057803Missense_MutationnovelL466P0.08
DLBCchr1764060490SilentnovelS395S0.16
ESCAchr1764054286Nonsense_MutationnovelY639*0.13
GBMchr1764047911Missense_Mutationrs758266847V826M0.12
GBMchr1764060537Missense_MutationNAP380S0.37
GBMchr1764054323Missense_MutationnovelR627L0.04
GBMchr1764066706Silentrs183713088P269P0.32
HNSCchr1764045474Silentrs751720267S846S0.19
HNSCchr1764066924Missense_MutationnovelH197D0.08
HNSCchr1764044079Missense_MutationnovelM948T0.28Ribonuc_2-5A
HNSCchr1764049149SilentnovelS769S0.48
HNSCchr1764043989Silentnovel*978*0.19
KIRCchr1764045467Frame_Shift_DelnovelI849*0.28Ribonuc_2-5A
KIRCchr1764064074SilentnovelV333V0.12
KIRPchr1764044188Missense_Mutationrs185854736R912W0.35Ribonuc_2-5A
LGGchr1764054306Missense_MutationnovelK633Q0.24
LGGchr1764066706Silentrs183713088P269P0.88
LGGchr1764045444SilentnovelG856G0.24
LGGchr1764047929Missense_MutationNAR820C0.36
LGGchr1764066927Missense_MutationnovelS196T0.32
LGGchr1764057837Missense_MutationnovelI455F0.09
LIHCchr1764057964Missense_MutationnovelE412D0.4
LIHCchr1764055863Missense_MutationnovelQ495L0.07
LIHCchr1764047946Missense_MutationnovelA814E0.07
LIHCchr17641301125'UTRnovel0.86
LUADchr1764049109Missense_MutationNAA783T0.25
LUADchr1764057819Missense_MutationnovelI461F0.1
LUADchr1764047858Missense_MutationnovelQ843H0.25Ribonuc_2-5A
LUADchr1764045416Missense_MutationnovelG866W0.6Ribonuc_2-5A
LUADchr1764068216Missense_MutationNAS185L0.12
LUADchr1764054358SilentnovelL615L0.48
LUADchr1764054280SilentNAA641A0.56
LUADchr1764066784SilentNAI243I0.1
LUADchr1764052853Missense_MutationnovelR727L0.09
LUADchr1764057985SilentnovelN405N0.15
LUADchr1764098185Silentrs374385951T37T0.19
LUADchr1764057805Silentrs375031481P465P0.1
LUADchr1764054313Nonsense_MutationnovelC630*0.17
LUSCchr1764053269Splice_Regionnovel0.15
LUSCchr1764068281SilentnovelI163I0.13
LUSCchr1764098225Missense_MutationNAS24N0.27
LUSCchr1764044062Missense_MutationNAE954K0.19Ribonuc_2-5A
LUSCchr1764060513Missense_MutationNAE388K0.27
LUSCchr1764057905Missense_MutationnovelR432L0.33
LUSCchr1764055729Missense_Mutationrs772826129G540S0.08
LUSCchr1764066918Missense_MutationnovelV199M0.34
LUSCchr1764066811SilentnovelR234R0.57
OVchr1764052891SilentnovelL714L0.09
OVchr1764064119In_Frame_InsnovelG318_P319insAVFLASV0.4
OVchr17640439623'UTRnovel0.48
OVchr1764098147Missense_MutationNAG50A0.13
OVchr1764066813Missense_MutationnovelR234G0.09
OVchr1764045409Missense_MutationNAA868D0.45Ribonuc_2-5A
OVchr1764057895SilentnovelA435A0.17
PAADchr1764047980Missense_MutationnovelV803I0.18
PAADchr1764052782Missense_MutationnovelP751S0.18
PAADchr1764057986Missense_Mutationrs780208953N405S0.29
PRADchr1764053316Frame_Shift_DelnovelQ670Rfs*200.27
PRADchr1764047929Missense_MutationNAR820C0.31
PRADchr1764053348Silentrs774733130A659A0.26
PRADchr1764063991Missense_MutationnovelL361P0.39
READchr1764052800Missense_Mutationrs750705699E745K0.38
SKCMchr1764044053Missense_MutationNAF957I0.25Ribonuc_2-5A
SKCMchr1764049182Missense_MutationnovelF758L0.34
SKCMchr1764064030Missense_MutationnovelS348N0.34
SKCMchr1764047896Missense_MutationnovelF831I0.1
SKCMchr1764060537Missense_MutationNAP380S0.34
SKCMchr1764047899Missense_MutationNAP830S0.24
SKCMchr1764066707Missense_Mutationrs777538073P269L0.32
SKCMchr1764053326Missense_MutationNAT667A0.27
SKCMchr1764053283Missense_MutationNAS681F0.2
SKCMchr1764055760Silentrs754109329S529S0.35
SKCMchr1764079722SilentnovelL74L0.43
SKCMchr1764057950Missense_MutationNAT417I0.31
SKCMchr1764052918SilentNAI705I0.7
SKCMchr1764044144Silentrs8077780P926P0.14
SKCMchr1764054792Missense_MutationNAS570F0.12
SKCMchr1764044081SilentNAA947A0.29
SKCMchr1764044140Missense_MutationNAD928N0.91Ribonuc_2-5A
SKCMchr1764054794SilentNAI569I0.44
SKCMchr1764054792Missense_MutationNAS570F0.44
SKCMchr1764052786Silentrs765646119E749E0.14
SKCMchr1764072020Missense_MutationNAL147F0.58
SKCMchr17640439733'UTRnovel0.22
SKCMchr1764044026Missense_MutationNAP966S0.11
SKCMchr1764054792Missense_MutationNAS570F0.45
SKCMchr1764047894Silentrs61745997F831F0.2
SKCMchr1764054792Missense_MutationNAS570F1
SKCMchr1764072094Missense_MutationNAQ122R0.2
SKCMchr1764057883SilentnovelS439S0.47
SKCMchr1764044109Missense_MutationNAP938L0.22Ribonuc_2-5A
SKCMchr1764060501Missense_MutationNAP392S0.34
SKCMchr1764054299Missense_MutationNAR635Q0.34
SKCMchr1764066766Silentrs746472253T249T0.31
STADchr1764045473Missense_Mutationrs766760061D847N0.21Ribonuc_2-5A
STADchr1764066745Missense_MutationNAM256I0.18
STADchr1764060563Missense_Mutationrs376936066A371V0.36
STADchr1764072036Silentrs763718430S141S0.67
STADchr1764066839Missense_MutationNAP225H0.31
STADchr1764047963Missense_MutationNAL808F0.27
STADchr1764057986Missense_Mutationrs780208953N405S0.36
STADchr1764072097Frame_Shift_DelnovelK121Sfs*110.21
STADchr1764045464Nonsense_MutationnovelE850*0.07Ribonuc_2-5A
STADchr1764064086SilentNAK329K0.23
STADchr17640439603'UTRrs7636977320.31
STADchr1764066847Silentrs757259673Y222Y0.21
STADchr1764054371Missense_MutationnovelR611H0.25
STADchr1764066847Silentrs757259673Y222Y0.38
STADchr1764054378Missense_MutationNAA609T0.25
UCECchr1764052902Missense_Mutationrs761547515D711N0.53
UCECchr1764066743Missense_MutationNAS257F0.53
UCECchr1764055688Missense_MutationnovelE553D0.43
UCECchr1764054354Nonsense_MutationnovelR617*0.48
UCECchr1764044165SilentnovelR919R0.07
UCECchr1764044086Missense_Mutationrs200358341R946W0.44Ribonuc_2-5A
UCECchr1764052973Missense_MutationnovelR687K0.36
UCECchr1764044135Missense_MutationnovelF929L0.44Ribonuc_2-5A
UCECchr1764098185Silentrs374385951T37T0.49
UCECchr1764068193Missense_MutationNAY193H0.55
UCECchr1764055678Nonsense_MutationNAG557*0.5
UCECchr1764055806Missense_MutationNAS514Y0.43
UCECchr1764052853Missense_Mutationrs769854043R727H0.71
UCECchr1764064125SilentnovelL316L0.33
UCECchr1764064007Missense_MutationnovelR356G0.37
UCECchr1764068222Missense_MutationnovelA183V0.28
UCECchr1764044117SilentnovelS935S0.5
UCECchr1764047948SilentnovelI813I0.24
UCECchr1764072086Missense_MutationnovelW125G0.48
UCECchr1764075175Missense_MutationnovelG119S0.18
UCECchr1764066699Frame_Shift_InsnovelK272Qfs*510.36
UCECchr1764066706Silentrs183713088P269P0.49
UCECchr1764055824Missense_MutationNAG508D0.38
UCECchr1764055740Missense_Mutationrs567044945S536L0.41
UCECchr1764054362Missense_MutationnovelQ614R0.3
UCECchr1764066789Missense_Mutationrs773561085H242Y0.49
UCECchr1764044057SilentnovelR955R0.16
UCECchr1764044921Missense_Mutationrs758628467R887H0.23Ribonuc_2-5A
UCECchr1764047946Missense_Mutationrs563941838A814V0.37
UCECchr1764054420Missense_Mutationrs201570900D595N0.35
UCECchr1764068259Nonsense_MutationnovelR171*0.4
UCECchr1764068251SilentNAL173L0.42
UCECchr1764044115Missense_Mutationrs756172050R936H0.3Ribonuc_2-5A
UCECchr17640438853'UTRnovel0.35
UCECchr1764044135SilentnovelF929F0.32
UCECchr1764060553Missense_MutationnovelK374N0.34
UCECchr1764044135SilentnovelF929F0.49
UCECchr1764044121Missense_MutationnovelT934I0.36Ribonuc_2-5A
UCECchr1764044135SilentnovelF929F0.08
UCECchr1764045389Missense_Mutationrs776930056R875W0.34Ribonuc_2-5A
UCECchr1764043994SilentnovelA976A0.42
UCECchr1764055796SilentnovelY517Y0.35
UCECchr1764044913Missense_MutationnovelR890G0.41Ribonuc_2-5A
UCECchr1764055874SilentnovelQ491Q0.38
UCECchr1764064086Missense_MutationnovelK329N0.27
UCECchr1764054739Missense_Mutationrs773459403R588W0.32
UCECchr1764045438SilentNAI858I0.34
UCECchr1764045452Missense_MutationnovelL854M0.17Ribonuc_2-5A
UCECchr1764047980Missense_MutationnovelV803I0.25
UCECchr1764066670Splice_SitenovelX281_splice0.38
UCECchr1764098124Nonsense_MutationnovelE58*0.26
UCECchr1764052926Missense_Mutationrs750842031G703S0.26
UCECchr1764055846Missense_MutationnovelP501S0.34
UCECchr1764043996Missense_Mutationrs142212892A976T0.33
UCECchr1764057942Missense_MutationNAR420W0.35
UCECchr1764066814SilentnovelQ233Q0.51
UCECchr1764044115Missense_Mutationrs756172050R936H0.42Ribonuc_2-5A

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCAAMP0.39710.00012456
DLBCDEL0.06250.18166
KIRPAMP0.66670.14801
LGGAMP0.05851.52e-05
READAMP0.18180.15915
SARCAMP0.2140.032181
THCADEL0.0020.221
UVMAMP0.16250.054583

Survival Analysis
CancerP-value Q-value
MESO0.0051

Kaplan-Meier Survival Analysis

ACC0.0003

Kaplan-Meier Survival Analysis

HNSC0.05

Kaplan-Meier Survival Analysis

SKCM0.015

Kaplan-Meier Survival Analysis

LUSC0.007

Kaplan-Meier Survival Analysis

KIRP0.0013

Kaplan-Meier Survival Analysis

BLCA0.039

Kaplan-Meier Survival Analysis

CESC0.015

Kaplan-Meier Survival Analysis

KICH0.0057

Kaplan-Meier Survival Analysis

UCEC0.0096

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

LUAD0.0069

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Paralogs
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000178607 (Gene tree)
Gene ID
2081
Gene Symbol
ERN1
Alias
IRE1|IRE1P
Full Name
endoplasmic reticulum to nucleus signaling 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
91,678 bases
Position
chr17:64,039,142-64,130,819
Accession
3449
RBP type
canonical RBP
Summary
This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1. [provided by RefSeq, Aug 2017]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000401445Ribonuc_2-5APF06479.123.3e-4011

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
26802109The Nrf2 Activator Vinylsulfone Reduces High Glucose-Induced Neural Tube Defects by Suppressing Cellular Stress and Apoptosis.Reprod Sci2016 AugDong Ddoi: 10.1177/1933719115625846
30973085Rutin hydrate inhibits apoptosis in the brains of cadmium chloride-treated rats via preserving the mitochondrial integrity and inhibiting endoplasmic reticulum stress.Neurol Res2019 JulMostafa DGdoi: 10.1080/01616412.2019.1596206
16205645Enhanced selenium effect on growth arrest by BiP/GRP78 knockdown in p53-null human prostate cancer cells.Oncogene2006 Jan 26Zu K-
16825573Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.Science2006 Jul 7Hollien J-
19651891Regulated Ire1-dependent decay of messenger RNAs in mammalian cells.J Cell Biol2009 Aug 10Hollien Jdoi: 10.1083/jcb.200903014
22321539Activation of the unfolded protein response by Listeria monocytogenes.Cell Microbiol2012 JunPillich Hdoi: 10.1111/j.1462-5822.2012.01769.x
22064246Endoplasmic reticulum stress signaling is involved in silver nanoparticles-induced apoptosis.Int J Biochem Cell Biol2012 JanZhang Rdoi: 10.1016/j.biocel.2011.10.019
25451798Di-O-demethylcurcumin protects SK-N-SH cells against mitochondrial and endoplasmic reticulum-mediated apoptotic cell death induced by Aβ25-35.Neurochem Int2015 JanPinkaew Ddoi: 10.1016/j.neuint.2014.10.008
25337580Dictyopteris undulata Extract Induces Apoptosis via Induction of Endoplasmic Reticulum Stress in Human Colon Cancer Cells.J Cancer Prev2014 JunKang KAdoi: 10.15430/JCP.2014.19.2.118.
24177270Tick-borne encephalitis virus triggers inositol-requiring enzyme 1 (IRE1) and transcription factor 6 (ATF6) pathways of unfolded protein response.Virus Res2013 Dec 26Yu Cdoi: 10.1016/j.virusres.2013.10.012
30556250Long noncoding RNA MEG3 inhibits breast cancer growth via upregulating endoplasmic reticulum stress and activating NF-kB and p53.J Cell Biochem2019 AprZhang Ydoi: 10.1002/jcb.27982
30606992Protective Effects of Alpha-Lipoic Acid on Glutamate-Induced Cytotoxicity in C6 Glioma Cells.Biol Pharm Bull2019Park Edoi: 10.1248/bpb.b18-00603.
16461360pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response.J Cell Biol2006 Feb 13Yoshida H-
23314846ER stress signalling through eIF2α and CHOP, but not IRE1α, attenuates adipogenesis in mice.Diabetologia2013 AprHan Jdoi: 10.1007/s00125-012-2809-5
28360534Involvement of endoplasmic reticulum stress in formalin-induced pain is attenuated by 4-phenylbutyric acid.J Pain Res2017 Mar 20Zhou Fdoi: 10.2147/JPR.S125805
27844183Evaluation and Treatment of Endoplasmic Reticulum (ER) Stress in Right Ventricular Dysfunction during Monocrotaline-Induced Rat Pulmonary Arterial Hypertension.Cardiovasc Drugs Ther2016 DecWang JJ-
24055755Exposure to tributyltin induces endoplasmic reticulum stress and the unfolded protein response in zebrafish.Aquat Toxicol2013 Oct 15Komoike Ydoi: 10.1016/j.aquatox.2013.08.017
27809414Salidroside protects against homocysteine-induced injury in human umbilical vein endothelial cells via the regulation of endoplasmic reticulum stress.Cardiovasc Ther2017 FebZhu Ldoi: 10.1111/1755-5922.12234.
26083833COPII-Dependent ER Export: A Critical Component of Insulin Biogenesis and β-Cell ER Homeostasis.Mol Endocrinol2015 AugFang Jdoi: 10.1210/me.2015-1012
29559889Endoplasmic Reticulum Stress in Spinal Cord Contributes to the Development of Morphine Tolerance.Front Mol Neurosci2018 Mar 6Liu Ddoi: 10.3389/fnmol.2018.00072
30612943Carbon monoxide releasing molecule-3 alleviates neuron death after spinal cord injury via inflammasome regulation.EBioMedicine2019 FebZheng Gdoi: 10.1016/j.ebiom.2018.12.059
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000433197ERN1-2017876XM_017024347ENSP00000401445977 (aa)XP_016879836O75460
ENST00000584041ERN1-207566--- (aa)--
ENST00000577567ERN1-202398--- (aa)--
ENST00000583077ERN1-205503--- (aa)--
ENST00000583028ERN1-204523--- (aa)--
ENST00000583896ERN1-206571--- (aa)--
ENST00000606895ERN1-2082068-ENSP0000047551970 (aa)-O75460
ENST00000579249ERN1-203548--- (aa)--
Gene Model
Click here to download ENSG00000178607's gene model file
Pathways
Pathway IDPathway NameSource
hsa04140Autophagy - animalKEGG
hsa04141Protein processing in endoplasmic reticulumKEGG
hsa04210ApoptosisKEGG
hsa04932Non-alcoholic fatty liver disease (NAFLD)KEGG
hsa05010Alzheimer diseaseKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000178607Stroke6.6206780E-00419369658
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000178607rs1996500821764044166TLiver injury in anti-retroviral drug treated HIV28388302[7.1-46.9]18.2EFO_0006904|EFO_0000764|EFO_0004228
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000178607's network

* RBP PPI network refers to all genes directly bind to RBP
Paralogs
Ensembl IDGene SymbolCoverageIdentiy ParalogGene SymbolCoverageIdentiy
ENSG00000178607ERN18763.387ENSG00000134398ERN29465.517
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000178607ERN19893.659ENSAMEG00000002855ERN19794.503Ailuropoda_melanoleuca
ENSG00000178607ERN19783.139ENSAPLG00000007775ERN19983.033Anas_platyrhynchos
ENSG00000178607ERN19879.522ENSACAG00000016707ERN19679.725Anolis_carolinensis
ENSG00000178607ERN110097.551ENSANAG00000019640ERN110097.551Aotus_nancymaae
ENSG00000178607ERN19994.289ENSBTAG00000016799ERN19894.363Bos_taurus
ENSG00000178607ERN110097.658ENSCJAG00000019415ERN110097.658Callithrix_jacchus
ENSG00000178607ERN19994.851ENSCAFG00000011784ERN19896.089Canis_familiaris
ENSG00000178607ERN19895.525ENSCAFG00020026580ERN19696.089Canis_lupus_dingo
ENSG00000178607ERN19894.050ENSCHIG00000025852ERN110093.946Capra_hircus
ENSG00000178607ERN19888.100ENSTSYG00000029092ERN19988.360Carlito_syrichta
ENSG00000178607ERN110088.127ENSCAPG00000011651ERN19889.677Cavia_aperea
ENSG00000178607ERN110093.552ENSCPOG00000000570ERN110093.756Cavia_porcellus
ENSG00000178607ERN19496.518ENSCCAG00000034845ERN110098.647Cebus_capucinus
ENSG00000178607ERN110098.874ENSCATG00000040819ERN110098.874Cercocebus_atys
ENSG00000178607ERN18796.540ENSCLAG00000006912ERN19896.540Chinchilla_lanigera
ENSG00000178607ERN110098.671ENSCSAG00000003990ERN110098.671Chlorocebus_sabaeus
ENSG00000178607ERN19780.882ENSCPBG00000009183ERN19581.529Chrysemys_picta_bellii
ENSG00000178607ERN19545.825ENSCSAVG00000010472-7460.247Ciona_savignyi
ENSG00000178607ERN110098.876ENSCANG00000032329ERN110098.876Colobus_angolensis_palliatus
ENSG00000178607ERN19893.750ENSCGRG00001003211Ern19893.737Cricetulus_griseus_chok1gshd
ENSG00000178607ERN19993.182ENSCGRG00000010036Ern19893.946Cricetulus_griseus_crigri
ENSG00000178607ERN110092.638ENSDNOG00000009467ERN19893.952Dasypus_novemcinctus
ENSG00000178607ERN19785.593ENSETEG00000004162ERN19485.503Echinops_telfairi
ENSG00000178607ERN15965.574ENSEBUG00000003040ERN17865.574Eptatretus_burgeri
ENSG00000178607ERN110093.252ENSEASG00005014413ERN19994.572Equus_asinus_asinus
ENSG00000178607ERN110095.599ENSECAG00000011262ERN19896.142Equus_caballus
ENSG00000178607ERN18694.836ENSEEUG00000006091ERN18194.836Erinaceus_europaeus
ENSG00000178607ERN19895.516ENSFCAG00000003507ERN19895.620Felis_catus
ENSG00000178607ERN19782.893ENSFALG00000002305ERN19683.121Ficedula_albicollis
ENSG00000178607ERN19893.848ENSFDAG00000013825ERN110093.848Fukomys_damarensis
ENSG00000178607ERN19981.470ENSGALG00000003476ERN19682.784Gallus_gallus
ENSG00000178607ERN18379.554ENSGAGG00000006329-9780.301Gopherus_agassizii
ENSG00000178607ERN110099.591ENSGGOG00000006532ERN110099.591Gorilla_gorilla
ENSG00000178607ERN110094.063ENSHGLG00000010207ERN19794.397Heterocephalus_glaber_female
ENSG00000178607ERN19894.161ENSHGLG00100019030ERN19994.397Heterocephalus_glaber_male
ENSG00000178607ERN19995.223ENSSTOG00000009067ERN110094.990Ictidomys_tridecemlineatus
ENSG00000178607ERN19875.364ENSLACG00000016078ERN19876.110Latimeria_chalumnae
ENSG00000178607ERN19776.280ENSLOCG00000013703ERN19676.514Lepisosteus_oculatus
ENSG00000178607ERN19895.193ENSLAFG00000008504ERN110095.298Loxodonta_africana
ENSG00000178607ERN110098.875ENSMFAG00000040147ERN110098.875Macaca_fascicularis
ENSG00000178607ERN110098.875ENSMMUG00000015185ERN110098.875Macaca_mulatta
ENSG00000178607ERN110098.671ENSMNEG00000044337ERN110098.671Macaca_nemestrina
ENSG00000178607ERN19898.957ENSMLEG00000033739ERN110098.957Mandrillus_leucophaeus
ENSG00000178607ERN19981.677ENSMGAG00000007831ERN19782.715Meleagris_gallopavo
ENSG00000178607ERN19995.643ENSMICG00000010050ERN19795.772Microcebus_murinus
ENSG00000178607ERN19893.021ENSMOCG00000003999Ern19892.902Microtus_ochrogaster
ENSG00000178607ERN19880.873ENSMODG00000009349ERN19880.977Monodelphis_domestica
ENSG00000178607ERN19993.146MGP_CAROLIEiJ_G0017324Ern19793.333Mus_caroli
ENSG00000178607ERN19893.215ENSMUSG00000020715Ern19793.333Mus_musculus
ENSG00000178607ERN19892.902MGP_PahariEiJ_G0018454Ern19892.797Mus_pahari
ENSG00000178607ERN19893.215MGP_SPRETEiJ_G0018168Ern19893.111Mus_spretus
ENSG00000178607ERN19994.872ENSMPUG00000014770ERN19994.917Mustela_putorius_furo
ENSG00000178607ERN19993.724ENSMLUG00000016729ERN19794.921Myotis_lucifugus
ENSG00000178607ERN19894.283ENSNGAG00000019135Ern19894.265Nannospalax_galili
ENSG00000178607ERN110099.284ENSNLEG00000015074ERN110099.284Nomascus_leucogenys
ENSG00000178607ERN19183.696ENSMEUG00000008103ERN18983.696Notamacropus_eugenii
ENSG00000178607ERN19891.684ENSOPRG00000008129ERN19992.179Ochotona_princeps
ENSG00000178607ERN19992.593ENSODEG00000007755ERN19993.229Octodon_degus
ENSG00000178607ERN19286.792ENSOANG00000008033ERN19986.942Ornithorhynchus_anatinus
ENSG00000178607ERN19894.075ENSOCUG00000012090ERN110093.667Oryctolagus_cuniculus
ENSG00000178607ERN19294.966ENSOGAG00000003863ERN19994.855Otolemur_garnettii
ENSG00000178607ERN19992.850ENSOARG00000014398ERN19893.118Ovis_aries
ENSG00000178607ERN110099.693ENSPPAG00000031054ERN110099.693Pan_paniscus
ENSG00000178607ERN19895.308ENSPPRG00000009424ERN19895.203Panthera_pardus
ENSG00000178607ERN19895.412ENSPTIG00000000179ERN19895.516Panthera_tigris_altaica
ENSG00000178607ERN110099.795ENSPTRG00000009535ERN110099.795Pan_troglodytes
ENSG00000178607ERN110099.079ENSPANG00000020738ERN110099.079Papio_anubis
ENSG00000178607ERN19879.791ENSPSIG00000017320ERN19880.403Pelodiscus_sinensis
ENSG00000178607ERN19893.841ENSPEMG00000002339Ern19893.528Peromyscus_maniculatus_bairdii
ENSG00000178607ERN19885.297ENSPCIG00000005771ERN19885.297Phascolarctos_cinereus
ENSG00000178607ERN19997.234ENSPPYG00000008539ERN110099.419Pongo_abelii
ENSG00000178607ERN19375.000ENSPCAG00000016275ERN110074.728Procavia_capensis
ENSG00000178607ERN19991.607ENSPCOG00000023564ERN19991.607Propithecus_coquereli
ENSG00000178607ERN19991.478ENSPVAG00000000484ERN19792.169Pteropus_vampyrus
ENSG00000178607ERN19993.250ENSRNOG00000012864Ern19993.319Rattus_norvegicus
ENSG00000178607ERN110098.773ENSRBIG00000033096ERN110098.773Rhinopithecus_bieti
ENSG00000178607ERN19997.846ENSRROG00000017577ERN110098.837Rhinopithecus_roxellana
ENSG00000178607ERN19995.282ENSSBOG00000035494ERN110098.721Saimiri_boliviensis_boliviensis
ENSG00000178607ERN19584.324ENSSHAG00000014118ERN110084.324Sarcophilus_harrisii
ENSG00000178607ERN19872.456ENSSFOG00015005661ern19573.545Scleropages_formosus
ENSG00000178607ERN19978.283ENSSPUG00000004797ERN19978.728Sphenodon_punctatus
ENSG00000178607ERN19893.946ENSSSCG00000017279ERN19893.841Sus_scrofa
ENSG00000178607ERN19782.770ENSTGUG00000004752-9983.085Taeniopygia_guttata
ENSG00000178607ERN19888.889ENSTTRG00000007006ERN19989.167Tursiops_truncatus
ENSG00000178607ERN19793.559ENSUAMG00000007437ERN19793.579Ursus_americanus
ENSG00000178607ERN19794.837ENSUMAG00000017551ERN19793.895Ursus_maritimus
ENSG00000178607ERN19795.886ENSVVUG00000006214ERN19596.089Vulpes_vulpes
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000287magnesium ion binding9637683.IDAFunction
GO:0001935endothelial cell proliferation23529610.IDAProcess
GO:0004521endoribonuclease activity21873635.IBAFunction
GO:0004521endoribonuclease activity9637683.11779465.19328063.21317875.IDAFunction
GO:0004672protein kinase activity21873635.IBAFunction
GO:0004674protein serine/threonine kinase activity21873635.IBAFunction
GO:0004674protein serine/threonine kinase activity9637683.21317875.IDAFunction
GO:0005161platelet-derived growth factor receptor binding26315405.IPIFunction
GO:0005515protein binding11278723.15234121.16645094.18369366.19135427.19328063.20103773.23529610.25241761.25742138.27238082.IPIFunction
GO:0005524ATP binding9637683.IDAFunction
GO:0005637nuclear inner membrane-IEAComponent
GO:0005737cytoplasm19622636.IDAComponent
GO:0005739mitochondrion-IEAComponent
GO:0005783endoplasmic reticulum23529610.IDAComponent
GO:0005789endoplasmic reticulum membrane21873635.IBAComponent
GO:0005789endoplasmic reticulum membrane-TASComponent
GO:0006379mRNA cleavage-ISSProcess
GO:0006402mRNA catabolic process22013210.TASProcess
GO:0006468protein phosphorylation9637683.IDAProcess
GO:0007050cell cycle arrest-ISSProcess
GO:0007257activation of JUN kinase activity10650002.IDAProcess
GO:0016241regulation of macroautophagy22013210.TASProcess
GO:0019899enzyme binding23103912.IPIFunction
GO:0030176integral component of endoplasmic reticulum membrane9637683.IDAComponent
GO:0030544Hsp70 protein binding20625543.IPIFunction
GO:0030968endoplasmic reticulum unfolded protein response21873635.IBAProcess
GO:0033120positive regulation of RNA splicing11779464.19622636.IDAProcess
GO:0034620cellular response to unfolded protein19328063.IDAProcess
GO:0034620cellular response to unfolded protein20625543.IMPProcess
GO:0034976response to endoplasmic reticulum stress10650002.IDAProcess
GO:0035924cellular response to vascular endothelial growth factor stimulus23529610.IDAProcess
GO:0036289peptidyl-serine autophosphorylation20103773.IDAProcess
GO:0036498IRE1-mediated unfolded protein response21873635.IBAProcess
GO:0036498IRE1-mediated unfolded protein response9637683.11779465.19328063.29198525.IDAProcess
GO:0036498IRE1-mediated unfolded protein response-TASProcess
GO:0042802identical protein binding12637535.21317875.IPIFunction
GO:0042803protein homodimerization activity21317875.29198525.IDAFunction
GO:0042803protein homodimerization activity-ISSFunction
GO:0043531ADP binding21317875.IDAFunction
GO:0046777protein autophosphorylation9637683.19328063.IDAProcess
GO:0051082unfolded protein binding21873635.IBAFunction
GO:0051879Hsp90 protein binding12446770.IDAFunction
GO:0070054mRNA splicing, via endonucleolytic cleavage and ligation11779464.19328063.19622636.21317875.IDAProcess
GO:0070054mRNA splicing, via endonucleolytic cleavage and ligation20625543.21317875.IMPProcess
GO:0070054mRNA splicing, via endonucleolytic cleavage and ligation22013210.TASProcess
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress21873635.IBAProcess
GO:0071333cellular response to glucose stimulus20103773.IDAProcess
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic-IEAProcess
GO:0098787mRNA cleavage involved in mRNA processing21317875.IDAProcess
GO:1900103positive regulation of endoplasmic reticulum unfolded protein response16645094.IMPProcess
GO:1901142insulin metabolic process20103773.IDAProcess
GO:1904707positive regulation of vascular smooth muscle cell proliferation26315405.IMPProcess
GO:1990332Ire1 complex19328063.NASComponent
GO:1990579peptidyl-serine trans-autophosphorylation21317875.IMPProcess
GO:1990597AIP1-IRE1 complex-IEAComponent
GO:1990604IRE1-TRAF2-ASK1 complex21873635.IBAComponent
GO:1990604IRE1-TRAF2-ASK1 complex23000344.IDAComponent
GO:1990630IRE1-RACK1-PP2A complex20103773.IDAComponent
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