EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
29321004	RCC2 over-expression in tumor cells alters apoptosis and drug sensitivity by regulating Rac1 activation.	BMC Cancer	2018 Jan 10	Wu N	doi: 10.1186/s12885-017-3908-y.
25910952	Regulator of Chromosome Condensation 2 Identifies High-Risk Patients within Both Major Phenotypes of Colorectal Cancer.	Clin Cancer Res	2015 Aug 15	Bruun J	doi: 10.1158/1078-0432.CCR-14-3294
29913439	LncRNA LCPAT1 Mediates Smoking/ Particulate Matter 2.5-Induced Cell Autophagy and Epithelial-Mesenchymal Transition in Lung Cancer Cells via RCC2.	Cell Physiol Biochem	2018	Lin H	doi: 10.1159/000490220

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr1	17409129	Missense_Mutation	novel	K510N	0.07
BLCA	chr1	17412166	Missense_Mutation	NA	E448K	0.49
BRCA	chr1	17408885	3'UTR	novel		0.35
BRCA	chr1	17413114	Silent	NA	V424V	0.42
BRCA	chr1	17409983	Missense_Mutation	NA	F485L	0.31
BRCA	chr1	17416539	Nonsense_Mutation	NA	Q323*	0.19
BRCA	chr1	17408956	3'UTR	novel		0.27
BRCA	chr1	17408819	3'UTR	novel		0.38
CESC	chr1	17407711	3'Flank	novel		0.61
CESC	chr1	17409129	Silent	novel	K510K	0.36
CESC	chr1	17408032	3'Flank	novel		0.5
CESC	chr1	17409100	Missense_Mutation	novel	R520Q	0.39
CESC	chr1	17413696	Nonsense_Mutation	rs772968944	R350*	0.37
CESC	chr1	17422729	Missense_Mutation	novel	R211W	0.33
CESC	chr1	17409024	3'UTR	novel		0.22
COAD	chr1	17408885	3'UTR	novel		0.67
COAD	chr1	17422817	Silent	NA	Q181Q	0.21
COAD	chr1	17416480	Splice_Region	NA	T342T	0.18
COAD	chr1	17410028	Silent	NA	K470K	0.32
COAD	chr1	17413594	Missense_Mutation	NA	R384C	0.19
COAD	chr1	17408885	3'UTR	novel		0.5
COAD	chr1	17413652	Silent	rs367926411	H364H	0.4
COAD	chr1	17413624	Missense_Mutation	NA	R374C	0.33
COAD	chr1	17422282	Missense_Mutation	NA	S222F	0.1
COAD	chr1	17416608	Missense_Mutation	NA	R300W	0.24
COAD	chr1	17413120	Frame_Shift_Del	novel	*A423Qfs56**	0.13
COAD	chr1	17409116	Missense_Mutation	NA	P515S	0.36
COAD	chr1	17413624	Missense_Mutation	NA	R374C	0.15
COAD	chr1	17408885	3'UTR	novel		0.89
COAD	chr1	17413089	Missense_Mutation	rs780378675	R433W	0.29
COAD	chr1	17416509	Nonsense_Mutation	rs757048358	R333*	0.28
COAD	chr1	17420770	In_Frame_Del	NA	M267del	0.32
COAD	chr1	17416550	Missense_Mutation	NA	T319M	0.24
DLBC	chr1	17420743	Missense_Mutation	NA	S277F	0.26
ESCA	chr1	17408885	3'UTR	novel		0.17
ESCA	chr1	17422819	Missense_Mutation	novel	Q181K	0.22
ESCA	chr1	17408885	3'UTR	rs541787761		0.14
ESCA	chr1	17420774	Missense_Mutation	novel	M267V	0.13
GBM	chr1	17422244	Missense_Mutation	novel	G235S	0.18
GBM	chr1	17422809	Missense_Mutation	novel	H184L	0.05
GBM	chr1	17422811	Silent	novel	G183G	0.05
GBM	chr1	17425622	Missense_Mutation	novel	V148L	0.15
GBM	chr1	17429129	Missense_Mutation	novel	R119Q	0.38
HNSC	chr1	17413634	Missense_Mutation	novel	E370D	0.06
HNSC	chr1	17422796	Missense_Mutation	novel	K188N	0.29
KIRC	chr1	17425646	Missense_Mutation	novel	H140N	0.38
KIRC	chr1	17409066	3'UTR	novel		0.2
KIRC	chr1	17422233	Silent	rs762579861	N238N	0.42
KIRC	chr1	17420714	Missense_Mutation	NA	G287R	0.16
LAML	chr1	17413537	Missense_Mutation	novel	G403S	0.35
LAML	chr1	17425644	Silent	novel	H140H	0.09
LGG	chr1	17409192	Splice_Region	novel	V489V	0.3
LIHC	chr1	17413642	Missense_Mutation	novel	K368E	0.26
LIHC	chr1	17416519	Silent	NA	N329N	0.28
LUAD	chr1	17429128	Silent	novel	R119R	0.11
LUAD	chr1	17438508	Missense_Mutation	NA	R3W	0.39
LUAD	chr1	17416567	Silent	novel	A313A	0.2
LUAD	chr1	17409101	Nonsense_Mutation	novel	R520*	0.2
LUAD	chr1	17409090	Nonstop_Mutation	novel	523Cext42	0.15
LUSC	chr1	17413097	Missense_Mutation	NA	W430L	0.26
LUSC	chr1	17413599	Missense_Mutation	novel	P382H	0.16
MESO	chr1	17416588	Silent	rs554058168	E306E	0.18
OV	chr1	17413102	Nonsense_Mutation	novel	C428*	0.62
OV	chr1	17413715	Splice_Region	novel	L343L	0.62
OV	chr1	17413550	Nonsense_Mutation	novel	*V399Gfs2**	0.06
OV	chr1	17425594	Frame_Shift_Ins	novel	*S157Yfs43**	0.08
OV	chr1	17422809	Missense_Mutation	novel	H184L	0.1
OV	chr1	17422811	Silent	novel	G183G	0.09
PAAD	chr1	17422213	Missense_Mutation	novel	S245I	0.11
PAAD	chr1	17422722	Missense_Mutation	novel	H213P	0.15
READ	chr1	17422729	Missense_Mutation	novel	R211W	0.42
READ	chr1	17429129	Missense_Mutation	novel	R119Q	0.4
READ	chr1	17408926	3'UTR	novel		0.29
READ	chr1	17422833	Missense_Mutation	rs765416456	R176Q	0.3
SKCM	chr1	17413704	Missense_Mutation	novel	S347F	0.1
SKCM	chr1	17413625	Silent	novel	P373P	0.29
SKCM	chr1	17413626	Missense_Mutation	novel	P373R	0.29
SKCM	chr1	17409066	3'UTR	novel		0.27
SKCM	chr1	17413145	Missense_Mutation	NA	S414F	0.26
SKCM	chr1	17422783	Missense_Mutation	novel	P193S	0.29
SKCM	chr1	17422784	Silent	rs775471110	A192A	0.3
SKCM	chr1	17429130	Nonsense_Mutation	NA	R119*	0.36
SKCM	chr1	17422210	Missense_Mutation	novel	P246L	0.13
SKCM	chr1	17420815	Frame_Shift_Del	novel	*G253Afs15**	0.1
SKCM	chr1	17416579	Silent	NA	P309P	0.06
STAD	chr1	17408913	3'UTR	novel		0.44
STAD	chr1	17409101	Frame_Shift_Del	novel	*R520Efs55**	0.2
STAD	chr1	17409151	Missense_Mutation	NA	E503A	0.34
STAD	chr1	17420828	Missense_Mutation	NA	I249L	0.15
STAD	chr1	17422756	Missense_Mutation	NA	E202K	0.24
STAD	chr1	17408948	3'UTR	rs761501463		0.16
STAD	chr1	17420730	Silent	NA	P281P	0.22
STAD	chr1	17413116	In_Frame_Del	novel	A423del	0.38
STAD	chr1	17438513	Translation_Start_Site	novel	M1?	0.25
STAD	chr1	17422827	Missense_Mutation	NA	E178G	0.2
STAD	chr1	17416621	Silent	rs188700442	I295I	0.1
STAD	chr1	17412147	Missense_Mutation	novel	G454D	0.27
THCA	chr1	17408999	3'UTR	novel		0.2
UCEC	chr1	17409989	Silent	novel	G483G	0.1
UCEC	chr1	17422266	Silent	novel	G227G	0.21
UCEC	chr1	17409134	Nonsense_Mutation	NA	E509*	0.34
UCEC	chr1	17425675	Missense_Mutation	NA	R130H	0.36
UCEC	chr1	17408885	3'UTR	novel		0.52
UCEC	chr1	17416635	Missense_Mutation	NA	D291H	0.31
UCEC	chr1	17407712	3'Flank	novel		0.44
UCEC	chr1	17408885	3'UTR	novel		0.38
UCEC	chr1	17429173	Silent	novel	G104G	0.26
UCEC	chr1	17416503	Missense_Mutation	rs777410556	V335M	0.49
UCEC	chr1	17408980	3'UTR	novel		0.22
UCEC	chr1	17422203	Missense_Mutation	NA	Q248H	0.18
UCEC	chr1	17410039	Frame_Shift_Ins	novel	*H467Ifs47**	0.53
UCEC	chr1	17422225	Missense_Mutation	NA	D241V	0.28
UCEC	chr1	17422231	Missense_Mutation	novel	Q239P	0.11
UCEC	chr1	17408930	3'UTR	novel		0.07
UCEC	chr1	17407712	3'Flank	novel		0.53
UCEC	chr1	17413151	Missense_Mutation	novel	N412T	0.41
UCEC	chr1	17420780	Missense_Mutation	novel	F265V	0.26
UCEC	chr1	17407924	3'Flank	novel		0.38
UCEC	chr1	17412174	Missense_Mutation	novel	A445V	0.31
UCEC	chr1	17422801	Missense_Mutation	rs761740023	T187A	0.36
UCEC	chr1	17407712	3'Flank	novel		0.38
UCEC	chr1	17408885	3'UTR	novel		0.18
UCEC	chr1	17408885	3'UTR	novel		0.5
UCEC	chr1	17413652	Silent	rs367926411	H364H	0.24
UCEC	chr1	17425666	Missense_Mutation	novel	G133D	0.35
UCEC	chr1	17408885	3'UTR	rs541787761		0.38
UCEC	chr1	17413594	Missense_Mutation	NA	R384C	0.59
UCEC	chr1	17420815	Missense_Mutation	novel	G253D	0.39
UCEC	chr1	17422279	Missense_Mutation	novel	V223E	0.43
UCEC	chr1	17408885	3'UTR	novel		0.32
UCEC	chr1	17407720	3'Flank	novel		0.46
UCEC	chr1	17408884	3'UTR	novel		0.38
UCEC	chr1	17413089	Missense_Mutation	rs780378675	R433W	0.17
UCEC	chr1	17407880	3'Flank	novel		0.33
UCEC	chr1	17407623	3'Flank	novel		0.57
UCEC	chr1	17416616	Missense_Mutation	novel	R297Q	0.38
UCEC	chr1	17408885	3'UTR	novel		0.31
UCEC	chr1	17407820	3'Flank	novel		0.56
UCEC	chr1	17409123	Silent	novel	K512K	0.46
UCEC	chr1	17429114	Missense_Mutation	novel	K124T	0.37
UCEC	chr1	17408885	3'UTR	novel		0.71
UCEC	chr1	17429130	Nonsense_Mutation	NA	R119*	0.24
UCEC	chr1	17407712	3'Flank	novel		0.45
UCEC	chr1	17408000	3'Flank	novel		0.5
UCEC	chr1	17408913	3'UTR	novel		0.39
UCEC	chr1	17407662	3'Flank	novel		0.48
UCEC	chr1	17425559	Missense_Mutation	novel	G169W	0.34
UCEC	chr1	17408981	3'UTR	novel		0.14
UCEC	chr1	17408885	3'UTR	novel		0.36
UCEC	chr1	17416519	Silent	NA	N329N	0.12
UCEC	chr1	17408885	3'UTR	novel		0.71
UCEC	chr1	17416607	Missense_Mutation	novel	R300Q	0.41
UCEC	chr1	17412153	Missense_Mutation	rs756158591	S452N	0.35
UCEC	chr1	17422833	Missense_Mutation	rs765416456	R176Q	0.3
UCEC	chr1	17429164	Missense_Mutation	novel	L107F	0.05
UCEC	chr1	17416569	Missense_Mutation	novel	A313T	0.33
UCEC	chr1	17407712	3'Flank	novel		0.29
UCEC	chr1	17416529	Missense_Mutation	NA	P326H	0.36
UCEC	chr1	17407963	3'Flank	novel		0.38
UCEC	chr1	17413094	Missense_Mutation	novel	R431I	0.46
UCEC	chr1	17422772	Silent	rs778413915	I196I	0.39

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BRCA	DEL	0.3676	1.4923e-44
CESC	DEL	0.0881	0.00029523
CHOL	DEL	0.8056	3.3987e-23
DLBC	DEL	0.1042	0.011841
HNSC	DEL	0.1398	7.0766e-07
KIRC	DEL	0.1439	2.3538e-09
KIRP	DEL	0.1736	1.462e-09
LIHC	DEL	0.3541	1.6679e-20
LUAD	DEL	0.1531	0.0024765
LUSC	DEL	0.3752	2.5882e-07
MESO	DEL	0.3333	2.434e-07
READ	DEL	0.4	2.1758e-10
TGCT	DEL	0.1733	0.00046313
UCS	DEL	0.2679	0.0051125

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
STAD	0.045	Kaplan-Meier Survival Analysis
SARC	0.00035	Kaplan-Meier Survival Analysis
MESO	0.012	Kaplan-Meier Survival Analysis
ACC	0.0001	Kaplan-Meier Survival Analysis
BRCA	0.013	Kaplan-Meier Survival Analysis
KIRP	0.019	Kaplan-Meier Survival Analysis
PAAD	0.001	Kaplan-Meier Survival Analysis
CESC	0.0013	Kaplan-Meier Survival Analysis
LIHC	0.00012	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.02	Kaplan-Meier Survival Analysis

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000179051 (Gene tree)
Gene ID: 55920
Gene Symbol: RCC2
Alias: TD-60
Full Name: regulator of chromosome condensation 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 33,000 bases
Position: chr1:17,406,755-17,439,754
Accession: 30297
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a guanine exchange factor that is active on RalA, a small GTPase. The encoded protein and RalA are both essential for proper kinetochore-microtubule function in early mitosis. This protein has been shown to be a biomarker for colorectal cancer. [provided by RefSeq, Oct 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
27145786	Dependence of the structure and mechanics of metaphase chromosomes on oxidized cysteines.	Chromosome Res	2016 Sep	Eastland A	doi: 10.1007/s10577-016-9528-6

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000375433	RCC2-201	2030	-	ENSP00000364582	522 (aa)	-	Q9P258
ENST00000375436	RCC2-202	4087	-	ENSP00000364585	522 (aa)	-	Q9P258
ENST00000474892	RCC2-203	783	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000179051's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000179051	Carcinoma, Basal Cell	1E-23	27539887

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000179051	rs7528427	1	17419777	C	Non-melanoma skin cancer	29739929	[1.18-1.27]	1.2195122	EFO_0009260
ENSG00000179051	rs57142672	1	17418040	G	Basal cell carcinoma	27539887	[NR]	1.13	EFO_0004193

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000179051's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000179051	RCC2	82	47.796	FBgn0031769	CG9135	98	43.825	Drosophila_melanogaster
ENSG00000179051	RCC2	100	95.977	ENSMUSG00000040945	Rcc2	100	95.977	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005085	guanyl-nucleotide exchange factor activity	-	IEA	Function
GO:0005515	protein binding	22282019.25074804.	IPI	Function
GO:0005730	nucleolus	-	IEA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005874	microtubule	-	IEA	Component
GO:0005886	plasma membrane	-	IEA	Component
GO:0007049	cell cycle	-	IEA	Process
GO:0007229	integrin-mediated signaling pathway	19738201.	IDA	Process
GO:0008017	microtubule binding	12919680.	IMP	Function
GO:0010762	regulation of fibroblast migration	-	IEA	Process
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	12919680.	IMP	Process
GO:0016020	membrane	25074804.	IDA	Component
GO:0019901	protein kinase binding	25074804.	IPI	Function
GO:0019904	protein domain specific binding	25074804.	IPI	Function
GO:0030334	regulation of cell migration	-	ISS	Process
GO:0030496	midbody	12919680.	IDA	Component
GO:0031267	small GTPase binding	25074804.	IPI	Function
GO:0031901	early endosome membrane	-	IEA	Component
GO:0034260	negative regulation of GTPase activity	25074804.	IMP	Process
GO:0034260	negative regulation of GTPase activity	-	ISS	Process
GO:0034506	chromosome, centromeric core domain	12919680.	IDA	Component
GO:0045184	establishment of protein localization	-	IEA	Process
GO:0048041	focal adhesion assembly	19738201.	IDA	Process
GO:0048365	Rac GTPase binding	12919680.	IPI	Function
GO:0051301	cell division	-	IEA	Process
GO:0051895	negative regulation of focal adhesion assembly	-	ISS	Process
GO:0051987	positive regulation of attachment of spindle microtubules to kinetochore	12919680.	IMP	Process
GO:0072356	chromosome passenger complex localization to kinetochore	12919680.	IMP	Process
GO:0090630	activation of GTPase activity	-	IEA	Process
GO:1900025	negative regulation of substrate adhesion-dependent cell spreading	-	ISS	Process
GO:1900027	regulation of ruffle assembly	-	IEA	Process
GO:1990023	mitotic spindle midzone	12919680.	IDA	Component

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.