EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
29321004RCC2 over-expression in tumor cells alters apoptosis and drug sensitivity by regulating Rac1 activation.BMC Cancer2018 Jan 10Wu Ndoi: 10.1186/s12885-017-3908-y.
25910952Regulator of Chromosome Condensation 2 Identifies High-Risk Patients within Both Major Phenotypes of Colorectal Cancer.Clin Cancer Res2015 Aug 15Bruun Jdoi: 10.1158/1078-0432.CCR-14-3294
29913439LncRNA LCPAT1 Mediates Smoking/ Particulate Matter 2.5-Induced Cell Autophagy and Epithelial-Mesenchymal Transition in Lung Cancer Cells via RCC2.Cell Physiol Biochem2018Lin Hdoi: 10.1159/000490220

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr117409129Missense_MutationnovelK510N0.07
BLCAchr117412166Missense_MutationNAE448K0.49
BRCAchr1174088853'UTRnovel0.35
BRCAchr117413114SilentNAV424V0.42
BRCAchr117409983Missense_MutationNAF485L0.31
BRCAchr117416539Nonsense_MutationNAQ323*0.19
BRCAchr1174089563'UTRnovel0.27
BRCAchr1174088193'UTRnovel0.38
CESCchr1174077113'Flanknovel0.61
CESCchr117409129SilentnovelK510K0.36
CESCchr1174080323'Flanknovel0.5
CESCchr117409100Missense_MutationnovelR520Q0.39
CESCchr117413696Nonsense_Mutationrs772968944R350*0.37
CESCchr117422729Missense_MutationnovelR211W0.33
CESCchr1174090243'UTRnovel0.22
COADchr1174088853'UTRnovel0.67
COADchr117422817SilentNAQ181Q0.21
COADchr117416480Splice_RegionNAT342T0.18
COADchr117410028SilentNAK470K0.32
COADchr117413594Missense_MutationNAR384C0.19
COADchr1174088853'UTRnovel0.5
COADchr117413652Silentrs367926411H364H0.4
COADchr117413624Missense_MutationNAR374C0.33
COADchr117422282Missense_MutationNAS222F0.1
COADchr117416608Missense_MutationNAR300W0.24
COADchr117413120Frame_Shift_DelnovelA423Qfs*560.13
COADchr117409116Missense_MutationNAP515S0.36
COADchr117413624Missense_MutationNAR374C0.15
COADchr1174088853'UTRnovel0.89
COADchr117413089Missense_Mutationrs780378675R433W0.29
COADchr117416509Nonsense_Mutationrs757048358R333*0.28
COADchr117420770In_Frame_DelNAM267del0.32
COADchr117416550Missense_MutationNAT319M0.24
DLBCchr117420743Missense_MutationNAS277F0.26
ESCAchr1174088853'UTRnovel0.17
ESCAchr117422819Missense_MutationnovelQ181K0.22
ESCAchr1174088853'UTRrs5417877610.14
ESCAchr117420774Missense_MutationnovelM267V0.13
GBMchr117422244Missense_MutationnovelG235S0.18
GBMchr117422809Missense_MutationnovelH184L0.05
GBMchr117422811SilentnovelG183G0.05
GBMchr117425622Missense_MutationnovelV148L0.15
GBMchr117429129Missense_MutationnovelR119Q0.38
HNSCchr117413634Missense_MutationnovelE370D0.06
HNSCchr117422796Missense_MutationnovelK188N0.29
KIRCchr117425646Missense_MutationnovelH140N0.38
KIRCchr1174090663'UTRnovel0.2
KIRCchr117422233Silentrs762579861N238N0.42
KIRCchr117420714Missense_MutationNAG287R0.16
LAMLchr117413537Missense_MutationnovelG403S0.35
LAMLchr117425644SilentnovelH140H0.09
LGGchr117409192Splice_RegionnovelV489V0.3
LIHCchr117413642Missense_MutationnovelK368E0.26
LIHCchr117416519SilentNAN329N0.28
LUADchr117429128SilentnovelR119R0.11
LUADchr117438508Missense_MutationNAR3W0.39
LUADchr117416567SilentnovelA313A0.2
LUADchr117409101Nonsense_MutationnovelR520*0.2
LUADchr117409090Nonstop_Mutationnovel*523Cext*420.15
LUSCchr117413097Missense_MutationNAW430L0.26
LUSCchr117413599Missense_MutationnovelP382H0.16
MESOchr117416588Silentrs554058168E306E0.18
OVchr117413102Nonsense_MutationnovelC428*0.62
OVchr117413715Splice_RegionnovelL343L0.62
OVchr117413550Nonsense_MutationnovelV399Gfs*20.06
OVchr117425594Frame_Shift_InsnovelS157Yfs*430.08
OVchr117422809Missense_MutationnovelH184L0.1
OVchr117422811SilentnovelG183G0.09
PAADchr117422213Missense_MutationnovelS245I0.11
PAADchr117422722Missense_MutationnovelH213P0.15
READchr117422729Missense_MutationnovelR211W0.42
READchr117429129Missense_MutationnovelR119Q0.4
READchr1174089263'UTRnovel0.29
READchr117422833Missense_Mutationrs765416456R176Q0.3
SKCMchr117413704Missense_MutationnovelS347F0.1
SKCMchr117413625SilentnovelP373P0.29
SKCMchr117413626Missense_MutationnovelP373R0.29
SKCMchr1174090663'UTRnovel0.27
SKCMchr117413145Missense_MutationNAS414F0.26
SKCMchr117422783Missense_MutationnovelP193S0.29
SKCMchr117422784Silentrs775471110A192A0.3
SKCMchr117429130Nonsense_MutationNAR119*0.36
SKCMchr117422210Missense_MutationnovelP246L0.13
SKCMchr117420815Frame_Shift_DelnovelG253Afs*150.1
SKCMchr117416579SilentNAP309P0.06
STADchr1174089133'UTRnovel0.44
STADchr117409101Frame_Shift_DelnovelR520Efs*550.2
STADchr117409151Missense_MutationNAE503A0.34
STADchr117420828Missense_MutationNAI249L0.15
STADchr117422756Missense_MutationNAE202K0.24
STADchr1174089483'UTRrs7615014630.16
STADchr117420730SilentNAP281P0.22
STADchr117413116In_Frame_DelnovelA423del0.38
STADchr117438513Translation_Start_SitenovelM1?0.25
STADchr117422827Missense_MutationNAE178G0.2
STADchr117416621Silentrs188700442I295I0.1
STADchr117412147Missense_MutationnovelG454D0.27
THCAchr1174089993'UTRnovel0.2
UCECchr117409989SilentnovelG483G0.1
UCECchr117422266SilentnovelG227G0.21
UCECchr117409134Nonsense_MutationNAE509*0.34
UCECchr117425675Missense_MutationNAR130H0.36
UCECchr1174088853'UTRnovel0.52
UCECchr117416635Missense_MutationNAD291H0.31
UCECchr1174077123'Flanknovel0.44
UCECchr1174088853'UTRnovel0.38
UCECchr117429173SilentnovelG104G0.26
UCECchr117416503Missense_Mutationrs777410556V335M0.49
UCECchr1174089803'UTRnovel0.22
UCECchr117422203Missense_MutationNAQ248H0.18
UCECchr117410039Frame_Shift_InsnovelH467Ifs*470.53
UCECchr117422225Missense_MutationNAD241V0.28
UCECchr117422231Missense_MutationnovelQ239P0.11
UCECchr1174089303'UTRnovel0.07
UCECchr1174077123'Flanknovel0.53
UCECchr117413151Missense_MutationnovelN412T0.41
UCECchr117420780Missense_MutationnovelF265V0.26
UCECchr1174079243'Flanknovel0.38
UCECchr117412174Missense_MutationnovelA445V0.31
UCECchr117422801Missense_Mutationrs761740023T187A0.36
UCECchr1174077123'Flanknovel0.38
UCECchr1174088853'UTRnovel0.18
UCECchr1174088853'UTRnovel0.5
UCECchr117413652Silentrs367926411H364H0.24
UCECchr117425666Missense_MutationnovelG133D0.35
UCECchr1174088853'UTRrs5417877610.38
UCECchr117413594Missense_MutationNAR384C0.59
UCECchr117420815Missense_MutationnovelG253D0.39
UCECchr117422279Missense_MutationnovelV223E0.43
UCECchr1174088853'UTRnovel0.32
UCECchr1174077203'Flanknovel0.46
UCECchr1174088843'UTRnovel0.38
UCECchr117413089Missense_Mutationrs780378675R433W0.17
UCECchr1174078803'Flanknovel0.33
UCECchr1174076233'Flanknovel0.57
UCECchr117416616Missense_MutationnovelR297Q0.38
UCECchr1174088853'UTRnovel0.31
UCECchr1174078203'Flanknovel0.56
UCECchr117409123SilentnovelK512K0.46
UCECchr117429114Missense_MutationnovelK124T0.37
UCECchr1174088853'UTRnovel0.71
UCECchr117429130Nonsense_MutationNAR119*0.24
UCECchr1174077123'Flanknovel0.45
UCECchr1174080003'Flanknovel0.5
UCECchr1174089133'UTRnovel0.39
UCECchr1174076623'Flanknovel0.48
UCECchr117425559Missense_MutationnovelG169W0.34
UCECchr1174089813'UTRnovel0.14
UCECchr1174088853'UTRnovel0.36
UCECchr117416519SilentNAN329N0.12
UCECchr1174088853'UTRnovel0.71
UCECchr117416607Missense_MutationnovelR300Q0.41
UCECchr117412153Missense_Mutationrs756158591S452N0.35
UCECchr117422833Missense_Mutationrs765416456R176Q0.3
UCECchr117429164Missense_MutationnovelL107F0.05
UCECchr117416569Missense_MutationnovelA313T0.33
UCECchr1174077123'Flanknovel0.29
UCECchr117416529Missense_MutationNAP326H0.36
UCECchr1174079633'Flanknovel0.38
UCECchr117413094Missense_MutationnovelR431I0.46
UCECchr117422772Silentrs778413915I196I0.39

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BRCADEL0.36761.4923e-44
CESCDEL0.08810.00029523
CHOLDEL0.80563.3987e-23
DLBCDEL0.10420.011841
HNSCDEL0.13987.0766e-07
KIRCDEL0.14392.3538e-09
KIRPDEL0.17361.462e-09
LIHCDEL0.35411.6679e-20
LUADDEL0.15310.0024765
LUSCDEL0.37522.5882e-07
MESODEL0.33332.434e-07
READDEL0.42.1758e-10
TGCTDEL0.17330.00046313
UCSDEL0.26790.0051125

Survival Analysis
CancerP-value Q-value
KIRC0.0001

Kaplan-Meier Survival Analysis

STAD0.045

Kaplan-Meier Survival Analysis

SARC0.00035

Kaplan-Meier Survival Analysis

MESO0.012

Kaplan-Meier Survival Analysis

ACC0.0001

Kaplan-Meier Survival Analysis

BRCA0.013

Kaplan-Meier Survival Analysis

KIRP0.019

Kaplan-Meier Survival Analysis

PAAD0.001

Kaplan-Meier Survival Analysis

CESC0.0013

Kaplan-Meier Survival Analysis

LIHC0.00012

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

LUAD0.02

Kaplan-Meier Survival Analysis

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000179051 (Gene tree)
Gene ID
55920
Gene Symbol
RCC2
Alias
TD-60
Full Name
regulator of chromosome condensation 2
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
33,000 bases
Position
chr1:17,406,755-17,439,754
Accession
30297
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is a guanine exchange factor that is active on RalA, a small GTPase. The encoded protein and RalA are both essential for proper kinetochore-microtubule function in early mitosis. This protein has been shown to be a biomarker for colorectal cancer. [provided by RefSeq, Oct 2016]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
27145786Dependence of the structure and mechanics of metaphase chromosomes on oxidized cysteines.Chromosome Res2016 SepEastland Adoi: 10.1007/s10577-016-9528-6
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000375433RCC2-2012030-ENSP00000364582522 (aa)-Q9P258
ENST00000375436RCC2-2024087-ENSP00000364585522 (aa)-Q9P258
ENST00000474892RCC2-203783--- (aa)--
Gene Model
Click here to download ENSG00000179051's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000179051Carcinoma, Basal Cell1E-2327539887
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000179051rs7528427117419777CNon-melanoma skin cancer29739929[1.18-1.27]1.2195122EFO_0009260
ENSG00000179051rs57142672117418040GBasal cell carcinoma27539887[NR]1.13EFO_0004193
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000179051's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000179051RCC28247.796FBgn0031769CG91359843.825Drosophila_melanogaster
ENSG00000179051RCC210095.977ENSMUSG00000040945Rcc210095.977Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0005085guanyl-nucleotide exchange factor activity-IEAFunction
GO:0005515protein binding22282019.25074804.IPIFunction
GO:0005730nucleolus-IEAComponent
GO:0005829cytosol-TASComponent
GO:0005874microtubule-IEAComponent
GO:0005886plasma membrane-IEAComponent
GO:0007049cell cycle-IEAProcess
GO:0007229integrin-mediated signaling pathway19738201.IDAProcess
GO:0008017microtubule binding12919680.IMPFunction
GO:0010762regulation of fibroblast migration-IEAProcess
GO:0010971positive regulation of G2/M transition of mitotic cell cycle12919680.IMPProcess
GO:0016020membrane25074804.IDAComponent
GO:0019901protein kinase binding25074804.IPIFunction
GO:0019904protein domain specific binding25074804.IPIFunction
GO:0030334regulation of cell migration-ISSProcess
GO:0030496midbody12919680.IDAComponent
GO:0031267small GTPase binding25074804.IPIFunction
GO:0031901early endosome membrane-IEAComponent
GO:0034260negative regulation of GTPase activity25074804.IMPProcess
GO:0034260negative regulation of GTPase activity-ISSProcess
GO:0034506chromosome, centromeric core domain12919680.IDAComponent
GO:0045184establishment of protein localization-IEAProcess
GO:0048041focal adhesion assembly19738201.IDAProcess
GO:0048365Rac GTPase binding12919680.IPIFunction
GO:0051301cell division-IEAProcess
GO:0051895negative regulation of focal adhesion assembly-ISSProcess
GO:0051987positive regulation of attachment of spindle microtubules to kinetochore12919680.IMPProcess
GO:0072356chromosome passenger complex localization to kinetochore12919680.IMPProcess
GO:0090630activation of GTPase activity-IEAProcess
GO:1900025negative regulation of substrate adhesion-dependent cell spreading-ISSProcess
GO:1900027regulation of ruffle assembly-IEAProcess
GO:1990023mitotic spindle midzone12919680.IDAComponent
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