Cancer | Chr | Position | Mutation Type | dbSNP | Protein-change | Allele Freq | RBD |
---|---|---|---|---|---|---|---|
BLCA | |||||||
BLCA | |||||||
BLCA | |||||||
BRCA | |||||||
BRCA | |||||||
BRCA | |||||||
BRCA | |||||||
BRCA | |||||||
CESC | |||||||
CESC | |||||||
CESC | |||||||
COAD | |||||||
COAD | |||||||
COAD | |||||||
COAD | |||||||
ESCA | |||||||
GBM | |||||||
GBM | |||||||
GBM | |||||||
GBM | |||||||
HNSC | |||||||
HNSC | |||||||
LAML | |||||||
LGG | |||||||
LGG | |||||||
LUAD | |||||||
LUAD | |||||||
LUSC | |||||||
LUSC | |||||||
LUSC | |||||||
OV | |||||||
OV | |||||||
PAAD | |||||||
PRAD | |||||||
SARC | |||||||
SARC | |||||||
SKCM | |||||||
SKCM | |||||||
STAD | |||||||
STAD | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC |
Cancer | Type | Freq | Q-value |
---|---|---|---|
DLBC | |||
KIRC | |||
LGG | |||
SARC | |||
SKCM | |||
TGCT | |||
UVM |
Cancer | P-value | Q-value |
---|---|---|
KIRC | ||
UCS | ||
COAD | ||
READ | ||
LAML | ||
GBM | ||
LIHC | ||
CHOL | ||
UVM | ||
OV |
Protein ID | Domain | Pfam ID | E-value | Domain number | Total number |
---|---|---|---|---|---|
ENSP00000432355 | zf-RanBP | PF00641.18 | 2.1e-06 | 1 | 1 |
Transcript ID | Name | Length | RefSeq ID | Protein ID | Length | RefSeq ID | UniportKB ID |
---|---|---|---|---|---|---|---|
ENST00000533184 | SHARPIN-207 | 352 | - | - | - (aa) | - | - |
ENST00000532536 | SHARPIN-206 | 533 | - | ENSP00000432355 | 95 (aa) | - | H0YCU2 |
ENST00000534435 | SHARPIN-210 | 656 | - | - | - (aa) | - | - |
ENST00000530216 | SHARPIN-204 | 673 | - | - | - (aa) | - | - |
ENST00000531375 | SHARPIN-205 | 613 | - | - | - (aa) | - | - |
ENST00000359551 | SHARPIN-201 | 1687 | - | ENSP00000352551 | 326 (aa) | - | Q9H0F6 |
ENST00000398712 | SHARPIN-202 | 1765 | XM_017013887 | ENSP00000381698 | 387 (aa) | XP_016869376 | Q9H0F6 |
ENST00000534242 | SHARPIN-209 | 933 | - | - | - (aa) | - | - |
ENST00000533948 | SHARPIN-208 | 981 | - | - | - (aa) | - | - |
ENST00000525275 | SHARPIN-203 | 521 | - | - | - (aa) | - | - |
ensgID | Trait | pValue | Pubmed ID |
---|---|---|---|
ENSG00000179526 | Metabolism | 6E-110 | 24816252 |
ensgID | SNP | Chromosome | Position | SNP-risk | Trait | PubmedID | 95% CI | Or or BEAT | EFO ID |
---|---|---|---|---|---|---|---|---|---|
ENSG00000179526 | rs12550729 | 8 | 144100505 | T | Blood metabolite levels | 24816252 | [0.058-0.07] unit increase | 0.064 | EFO_0005664 |
ENSG00000179526 | rs34173062 | 8 | 144103704 | A | Neutrophil percentage of granulocytes | 27863252 | [0.044-0.073] unit decrease | 0.05862283 | EFO_0007994 |
ENSG00000179526 | rs34173062 | 8 | 144103704 | A | Eosinophil percentage of granulocytes | 27863252 | [0.046-0.074] unit increase | 0.0599948 | EFO_0007996 |
ENSG00000179526 | rs34173062 | 8 | 144103704 | A | Sum eosinophil basophil counts | 27863252 | [0.043-0.072] unit increase | 0.05751766 | EFO_0005090|EFO_0004842 |
ENSG00000179526 | rs34173062 | 8 | 144103704 | A | Eosinophil percentage of white cells | 27863252 | [0.045-0.074] unit increase | 0.05961465 | EFO_0007991 |
ENSG00000179526 | rs34173062 | 8 | 144103704 | A | Eosinophil counts | 27863252 | [0.045-0.074] unit increase | 0.05925318 | EFO_0004842 |
ENSG00000179526 | rs34173062 | 8 | 144103704 | ? | Respiratory diseases | 30595370 | EFO_0000684 | ||
ENSG00000179526 | rs34173062 | 8 | 144103704 | ? | Eosinophil counts | 30595370 | EFO_0004842 |
Ensembl ID | Gene Symbol | Coverage | Identiy | Ortholog | Gene Symbol | Coverage | Identiy | Species |
---|---|---|---|---|---|---|---|---|
ENSG00000179526 | SHARPIN | 100 | 85.263 | ENSAMEG00000006042 | SHARPIN | 95 | 82.173 | Ailuropoda_melanoleuca |
ENSG00000179526 | SHARPIN | 88 | 38.931 | ENSACAG00000007245 | - | 54 | 40.000 | Anolis_carolinensis |
ENSG00000179526 | SHARPIN | 100 | 80.000 | ENSCAFG00000001536 | SHARPIN | 95 | 76.880 | Canis_familiaris |
ENSG00000179526 | SHARPIN | 100 | 89.474 | ENSCCAG00000036190 | SHARPIN | 93 | 91.643 | Cebus_capucinus |
ENSG00000179526 | SHARPIN | 97 | 66.304 | ENSDORG00000008469 | Sharpin | 99 | 71.386 | Dipodomys_ordii |
ENSG00000179526 | SHARPIN | 100 | 85.263 | ENSECAG00000001400 | SHARPIN | 88 | 83.242 | Equus_caballus |
ENSG00000179526 | SHARPIN | 100 | 85.263 | ENSECAG00000002550 | - | 86 | 82.967 | Equus_caballus |
ENSG00000179526 | SHARPIN | 100 | 85.263 | ENSFCAG00000011548 | SHARPIN | 93 | 82.173 | Felis_catus |
ENSG00000179526 | SHARPIN | 92 | 39.348 | ENSGALG00000048524 | SHARPIN | 75 | 38.667 | Gallus_gallus |
ENSG00000179526 | SHARPIN | 100 | 97.895 | ENSGGOG00000027471 | SHARPIN | 97 | 97.508 | Gorilla_gorilla |
ENSG00000179526 | SHARPIN | 91 | 72.093 | MGP_CAROLIEiJ_G0019922 | Sharpin | 100 | 72.093 | Mus_caroli |
ENSG00000179526 | SHARPIN | 91 | 73.256 | ENSMUSG00000022552 | Sharpin | 99 | 73.256 | Mus_musculus |
ENSG00000179526 | SHARPIN | 91 | 70.930 | MGP_PahariEiJ_G0019932 | Sharpin | 100 | 70.930 | Mus_pahari |
ENSG00000179526 | SHARPIN | 91 | 73.256 | MGP_SPRETEiJ_G0020825 | Sharpin | 100 | 73.256 | Mus_spretus |
ENSG00000179526 | SHARPIN | 100 | 85.263 | ENSPPRG00000015953 | SHARPIN | 93 | 81.337 | Panthera_pardus |
ENSG00000179526 | SHARPIN | 100 | 85.263 | ENSPTIG00000016864 | SHARPIN | 83 | 79.439 | Panthera_tigris_altaica |
ENSG00000179526 | SHARPIN | 58 | 43.333 | ENSSPUG00000017933 | SHARPIN | 73 | 42.222 | Sphenodon_punctatus |
ENSG00000179526 | SHARPIN | 100 | 77.895 | ENSSSCG00000005914 | SHARPIN | 87 | 77.716 | Sus_scrofa |
ENSG00000179526 | SHARPIN | 99 | 85.106 | ENSUMAG00000020808 | SHARPIN | 71 | 79.608 | Ursus_maritimus |
Go ID | Go_term | PubmedID | Evidence | Category |
---|---|---|---|---|
GO:0004842 | ubiquitin-protein transferase activity | 21873635. | IBA | Function |
GO:0005515 | protein binding | 21455173.21455180.21455181.21709223.21947080.22158122.23032186.23104095.24141947.27070702. | IPI | Function |
GO:0005829 | cytosol | 20179993. | IDA | Component |
GO:0005829 | cytosol | - | TAS | Component |
GO:0007005 | mitochondrion organization | - | IEA | Process |
GO:0007249 | I-kappaB kinase/NF-kappaB signaling | - | TAS | Process |
GO:0007420 | brain development | - | IEA | Process |
GO:0010803 | regulation of tumor necrosis factor-mediated signaling pathway | 21455173. | IDA | Process |
GO:0010803 | regulation of tumor necrosis factor-mediated signaling pathway | - | TAS | Process |
GO:0014069 | postsynaptic density | - | IEA | Component |
GO:0030054 | cell junction | - | IEA | Component |
GO:0030262 | apoptotic nuclear changes | - | IEA | Process |
GO:0030425 | dendrite | - | IEA | Component |
GO:0031424 | keratinization | - | IEA | Process |
GO:0031593 | polyubiquitin modification-dependent protein binding | 21455173.21455181. | IDA | Function |
GO:0042802 | identical protein binding | - | IEA | Function |
GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 21873635. | IBA | Process |
GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 21455173. | IDA | Process |
GO:0043130 | ubiquitin binding | 21873635. | IBA | Function |
GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 21873635. | IBA | Process |
GO:0044877 | protein-containing complex binding | - | IEA | Function |
GO:0046872 | metal ion binding | - | IEA | Function |
GO:0050728 | negative regulation of inflammatory response | - | ISS | Process |
GO:0051260 | protein homooligomerization | - | IEA | Process |
GO:0071797 | LUBAC complex | 21873635. | IBA | Component |
GO:0071797 | LUBAC complex | 21455173.21455180.21455181.24726323.27523608. | IDA | Component |
GO:0097039 | protein linear polyubiquitination | 21873635. | IBA | Process |
GO:0097039 | protein linear polyubiquitination | 21455173.21455180.21455181. | IDA | Process |
GO:2000348 | regulation of CD40 signaling pathway | 21455173. | IDA | Process |