EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr3	160678282	3'UTR	novel		0.36
BLCA	chr3	160677823	Silent	novel	L159L	0.17
BLCA	chr3	160677765	Missense_Mutation	novel	F140S	0.11
BLCA	chr3	160677793	Silent	novel	R149R	0.17
BLCA	chr3	160677614	Missense_Mutation	NA	D90N	0.15	MMR_HSR1
BRCA	chr3	160677933	3'UTR	rs765778567		0.06
CESC	chr3	160678279	3'UTR	novel		0.33
COAD	chr3	160677926	3'UTR	novel		0.21
COAD	chr3	160677324	5'UTR	novel		0.33
COAD	chr3	160677556	Missense_Mutation	novel	K70N	0.04	MMR_HSR1
COAD	chr3	160677575	Missense_Mutation	rs762555229	C77R	0.21	MMR_HSR1
COAD	chr3	160678162	3'UTR	novel		0.23
COAD	chr3	160677306	5'UTR	novel		0.48
COAD	chr3	160677479	Missense_Mutation	novel	I45L	0.37	MMR_HSR1
COAD	chr3	160678030	3'UTR	novel		0.1
COAD	chr3	160678328	3'UTR	novel		0.19
COAD	chr3	160677701	Missense_Mutation	NA	V119I	0.11	MMR_HSR1
DLBC	chr3	160678176	3'UTR	novel		0.28
ESCA	chr3	160678183	3'UTR	novel		0.13
GBM	chr3	160677937	3'UTR	novel		0.07
GBM	chr3	160677907	Silent	rs773857380	A187A	0.29
GBM	chr3	160677962	3'UTR	novel		0.11
GBM	chr3	160677573	Missense_Mutation	novel	G76D	0.49	MMR_HSR1
GBM	chr3	160677864	Missense_Mutation	novel	G173E	0.15
HNSC	chr3	160677737	Missense_Mutation	novel	L131V	0.19
HNSC	chr3	160677781	Frame_Shift_Ins	novel	*E162Sfs27**	0.14
HNSC	chr3	160677791	Silent	novel	R149R	0.46
HNSC	chr3	160677754	Silent	novel	I136I	0.24
LGG	chr3	160677355	Silent	rs144011121	S3S	0.52
LIHC	chr3	160677383	Nonsense_Mutation	NA	Q13*	0.06
LUAD	chr3	160677321	5'UTR	novel		0.11
LUAD	chr3	160677414	Nonsense_Mutation	novel	S23*	0.47	MMR_HSR1
LUAD	chr3	160677789	Missense_Mutation	novel	D148G	0.29
LUSC	chr3	160677929	3'UTR	novel		0.45
LUSC	chr3	160677502	Silent	rs776701439	I52I	0.15
OV	chr3	160677821	Missense_Mutation	novel	L159I	0.04
OV	chr3	160677503	Missense_Mutation	rs573150490	E53K	0.09	MMR_HSR1
READ	chr3	160677652	Silent	novel	R102R	0.29
READ	chr3	160678085	3'UTR	novel		0.59
READ	chr3	160678086	3'UTR	novel		0.32
READ	chr3	160677367	Silent	NA	K7K	0.42
SARC	chr3	160677334	5'UTR	novel		0.18
SKCM	chr3	160677511	Silent	NA	E55E	0.26
SKCM	chr3	160677828	Missense_Mutation	rs759219063	G161E	0.36
SKCM	chr3	160677853	Silent	novel	R169R	0.27
SKCM	chr3	160677502	Silent	rs776701439	I52I	0.32
SKCM	chr3	160677593	Missense_Mutation	rs35634980	D83N	0.36	MMR_HSR1
SKCM	chr3	160677332	5'UTR	novel		0.18
SKCM	chr3	160677293	5'UTR	novel		0.3
SKCM	chr3	160677514	Silent	novel	R56R	0.4
SKCM	chr3	160677729	Missense_Mutation	NA	P128L	0.44
SKCM	chr3	160677939	3'UTR	novel		0.47
STAD	chr3	160677686	Frame_Shift_Del	novel	*N115Mfs7**	0.23	MMR_HSR1
STAD	chr3	160677298	5'UTR	novel		0.42
STAD	chr3	160677686	Frame_Shift_Del	novel	*N115Mfs7**	0.13	MMR_HSR1
STAD	chr3	160677343	5'UTR	novel		0.29
THCA	chr3	160677724	Frame_Shift_Ins	novel	*M127Cfs3**	0.04
UCEC	chr3	160677274	5'UTR	novel		0.43
UCEC	chr3	160678036	3'UTR	novel		0.33
UCEC	chr3	160677225	5'UTR	novel		0.71
UCEC	chr3	160677398	Missense_Mutation	NA	L18I	0.19	MMR_HSR1
UCEC	chr3	160678021	3'UTR	novel		0.16
UCEC	chr3	160677518	Missense_Mutation	rs17853289	L58F	0.3	MMR_HSR1
UCEC	chr3	160677347	Translation_Start_Site	novel	M1?	0.24
UCEC	chr3	160677963	3'UTR	novel		0.27
UCEC	chr3	160677354	Missense_Mutation	rs139090920	S3L	0.22
UCEC	chr3	160678085	3'UTR	novel		0.47
UCEC	chr3	160678219	3'UTR	novel		0.22
UCEC	chr3	160677328	5'UTR	rs747630242		0.18
UCEC	chr3	160677907	Silent	rs773857380	A187A	0.44
UCEC	chr3	160677372	Missense_Mutation	rs754095868	P9L	0.6
UCEC	chr3	160677853	Missense_Mutation	novel	R169S	0.53
UCEC	chr3	160677463	Missense_Mutation	novel	I39M	0.12	MMR_HSR1
UCEC	chr3	160677397	Frame_Shift_Ins	novel	*L18Pfs5**	0.45	MMR_HSR1
UCEC	chr3	160677823	Silent	novel	L159L	0.39
UCEC	chr3	160678418	3'UTR	novel		0.36
UCEC	chr3	160677376	Missense_Mutation	novel	Q10H	0.42
UCEC	chr3	160677561	Missense_Mutation	rs760666218	R72I	0.24	MMR_HSR1
UCEC	chr3	160677359	Missense_Mutation	novel	G5C	0.26
UCEC	chr3	160678147	3'UTR	novel		0.41
UCEC	chr3	160678346	3'UTR	novel		0.33
UCEC	chr3	160678152	3'UTR	novel		0.22
UCEC	chr3	160678309	3'UTR	rs757665619		0.34
UCEC	chr3	160677686	Frame_Shift_Del	novel	*N115Mfs7**	0.09	MMR_HSR1
UCEC	chr3	160677616	Silent	NA	D90D	0.31
UCEC	chr3	160677944	3'UTR	novel		0.64
UCEC	chr3	160677285	5'UTR	novel		0.33
UCEC	chr3	160677552	Frame_Shift_Ins	novel	*E69Dfs12**	0.06	MMR_HSR1
UCEC	chr3	160677623	Missense_Mutation	NA	D93Y	0.24	MMR_HSR1
UCS	chr3	160677479	Missense_Mutation	novel	I45L	0.32	MMR_HSR1

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRC	DEL	0.1061	0.11092
KIRP	AMP	0.3125	0.15981
PAAD	AMP	0.1141	0.16151

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00093	Kaplan-Meier Survival Analysis
ACC	0.022	Kaplan-Meier Survival Analysis
UCS	0.047	Kaplan-Meier Survival Analysis
PRAD	0.043	Kaplan-Meier Survival Analysis
LUSC	0.019	Kaplan-Meier Survival Analysis
KIRP	0.0075	Kaplan-Meier Survival Analysis
PAAD	0.00016	Kaplan-Meier Survival Analysis
BLCA	0.017	Kaplan-Meier Survival Analysis
CESC	0.015	Kaplan-Meier Survival Analysis
READ	0.014	Kaplan-Meier Survival Analysis
UCEC	0.0089	Kaplan-Meier Survival Analysis
LIHC	0.0043	Kaplan-Meier Survival Analysis
LUAD	0.00029	Kaplan-Meier Survival Analysis
OV	0.031	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000179674 (Gene tree)
Gene ID: 80117
Gene Symbol: ARL14
Alias: FLJ22595|ARF7
Full Name: ADP ribosylation factor like GTPase 14
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 1,294 bases
Position: chr3:160,677,159-160,678,452
Accession: 22974
RBP type: canonical RBP
Summary: ARL14 (ADP Ribosylation Factor Like GTPase 14) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTP binding and obsolete signal transducer activity. An important paralog of this gene is ARL11.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000323847	MMR_HSR1	PF01926.23	3.8e-06	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000320767	ARL14-201	1294	-	ENSP00000323847	192 (aa)	-	Q8N4G2

Gene Model

Click here to download ENSG00000179674's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000179674	Subcutaneous Fat	7.97999786095183E-5	17903300
ENSG00000179674	Brain	9.0030247551276E-5	17903297
ENSG00000179674	Bronchodilator Agents	7E-7	26634245
ENSG00000179674	Forced Expiratory Volume	7E-7	26634245
ENSG00000179674	Bronchodilator Agents	3E-6	26634245
ENSG00000179674	Lung Volume Measurements	3E-6	26634245
ENSG00000179674	Arthritis, Rheumatoid	4E-7	24583629
ENSG00000179674	Methotrexate	4E-7	24583629

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000179674's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000179674	ARL14	100	87.500	ENSAMEG00000019231	ARL14	100	87.500	Ailuropoda_melanoleuca
ENSG00000179674	ARL14	98	64.894	ENSAPLG00000001749	ARL14	98	64.894	Anas_platyrhynchos
ENSG00000179674	ARL14	100	64.062	ENSACAG00000007333	ARL14	100	64.062	Anolis_carolinensis
ENSG00000179674	ARL14	100	83.333	ENSBTAG00000017322	ARL14	100	83.333	Bos_taurus
ENSG00000179674	ARL14	96	86.413	ENSCAFG00020021117	ARL14	96	86.413	Canis_lupus_dingo
ENSG00000179674	ARL14	100	80.729	ENSCHIG00000006468	ARL14	100	80.729	Capra_hircus
ENSG00000179674	ARL14	99	84.817	ENSCAPG00000007964	ARL14	99	84.817	Cavia_aperea
ENSG00000179674	ARL14	99	84.817	ENSCPOG00000010678	ARL14	99	84.817	Cavia_porcellus
ENSG00000179674	ARL14	100	96.875	ENSCATG00000017494	ARL14	100	96.875	Cercocebus_atys
ENSG00000179674	ARL14	100	96.875	ENSCSAG00000018891	ARL14	100	96.875	Chlorocebus_sabaeus
ENSG00000179674	ARL14	100	82.292	ENSCHOG00000002404	ARL14	100	82.292	Choloepus_hoffmanni
ENSG00000179674	ARL14	86	69.880	ENSCPBG00000018327	ARL14	89	69.880	Chrysemys_picta_bellii
ENSG00000179674	ARL14	100	97.396	ENSCANG00000014873	ARL14	100	97.396	Colobus_angolensis_palliatus
ENSG00000179674	ARL14	99	79.688	ENSCGRG00001008210	Arl14	99	79.688	Cricetulus_griseus_chok1gshd
ENSG00000179674	ARL14	99	79.688	ENSCGRG00000020042	Arl14	99	79.688	Cricetulus_griseus_crigri
ENSG00000179674	ARL14	100	80.729	ENSETEG00000000437	ARL14	100	80.729	Echinops_telfairi
ENSG00000179674	ARL14	89	84.795	ENSEASG00005019793	ARL14	92	84.795	Equus_asinus_asinus
ENSG00000179674	ARL14	100	87.500	ENSECAG00000007772	ARL14	100	87.500	Equus_caballus
ENSG00000179674	ARL14	100	81.771	ENSEEUG00000015705	ARL14	100	81.771	Erinaceus_europaeus
ENSG00000179674	ARL14	100	88.021	ENSFCAG00000004686	ARL14	100	88.021	Felis_catus
ENSG00000179674	ARL14	95	60.989	ENSFALG00000014391	ARL14	95	60.989	Ficedula_albicollis
ENSG00000179674	ARL14	99	80.105	ENSFDAG00000000707	ARL14	99	80.105	Fukomys_damarensis
ENSG00000179674	ARL14	98	62.234	ENSGALG00000043623	ARL14	97	62.234	Gallus_gallus
ENSG00000179674	ARL14	86	71.084	ENSGAGG00000014586	ARL14	82	71.084	Gopherus_agassizii
ENSG00000179674	ARL14	100	98.438	ENSGGOG00000036228	ARL14	100	98.438	Gorilla_gorilla
ENSG00000179674	ARL14	99	83.246	ENSHGLG00000020760	ARL14	99	83.246	Heterocephalus_glaber_female
ENSG00000179674	ARL14	99	83.246	ENSHGLG00100019770	ARL14	99	83.246	Heterocephalus_glaber_male
ENSG00000179674	ARL14	99	86.387	ENSSTOG00000003371	ARL14	99	86.387	Ictidomys_tridecemlineatus
ENSG00000179674	ARL14	100	81.771	ENSLAFG00000010461	ARL14	100	81.771	Loxodonta_africana
ENSG00000179674	ARL14	100	96.875	ENSMFAG00000028826	ARL14	100	96.875	Macaca_fascicularis
ENSG00000179674	ARL14	100	96.354	ENSMMUG00000031560	ARL14	100	96.354	Macaca_mulatta
ENSG00000179674	ARL14	100	96.875	ENSMNEG00000026952	ARL14	100	96.875	Macaca_nemestrina
ENSG00000179674	ARL14	100	96.875	ENSMLEG00000028348	ARL14	100	96.875	Mandrillus_leucophaeus
ENSG00000179674	ARL14	100	63.542	ENSMGAG00000016061	ARL14	100	63.542	Meleagris_gallopavo
ENSG00000179674	ARL14	99	78.646	ENSMAUG00000015654	Arl14	99	78.646	Mesocricetus_auratus
ENSG00000179674	ARL14	100	86.979	ENSMICG00000049117	ARL14	100	86.979	Microcebus_murinus
ENSG00000179674	ARL14	99	75.521	ENSMOCG00000004173	Arl14	99	75.521	Microtus_ochrogaster
ENSG00000179674	ARL14	100	70.466	ENSMODG00000024630	ARL14	100	70.466	Monodelphis_domestica
ENSG00000179674	ARL14	99	75.000	MGP_CAROLIEiJ_G0025066	Arl14	99	75.000	Mus_caroli
ENSG00000179674	ARL14	99	75.000	ENSMUSG00000098207	Arl14	99	75.000	Mus_musculus
ENSG00000179674	ARL14	99	76.562	MGP_PahariEiJ_G0026509	Arl14	99	76.562	Mus_pahari
ENSG00000179674	ARL14	99	75.521	MGP_SPRETEiJ_G0026008	Arl14	99	75.521	Mus_spretus
ENSG00000179674	ARL14	96	84.783	ENSMPUG00000018993	ARL14	100	84.783	Mustela_putorius_furo
ENSG00000179674	ARL14	100	82.292	ENSMLUG00000013429	ARL14	100	82.292	Myotis_lucifugus
ENSG00000179674	ARL14	99	78.238	ENSNGAG00000017340	Arl14	99	78.238	Nannospalax_galili
ENSG00000179674	ARL14	100	97.396	ENSNLEG00000030124	ARL14	100	97.396	Nomascus_leucogenys
ENSG00000179674	ARL14	97	69.355	ENSMEUG00000001341	ARL14	97	69.355	Notamacropus_eugenii
ENSG00000179674	ARL14	62	79.832	ENSOPRG00000001028	-	100	79.832	Ochotona_princeps
ENSG00000179674	ARL14	100	68.394	ENSOANG00000009134	ARL14	100	68.394	Ornithorhynchus_anatinus
ENSG00000179674	ARL14	99	85.864	ENSOCUG00000021985	ARL14	99	85.864	Oryctolagus_cuniculus
ENSG00000179674	ARL14	100	77.083	ENSOGAG00000033920	ARL14	100	77.083	Otolemur_garnettii
ENSG00000179674	ARL14	100	81.250	ENSOARG00000014982	ARL14	100	81.250	Ovis_aries
ENSG00000179674	ARL14	100	98.958	ENSPPAG00000017014	ARL14	100	98.958	Pan_paniscus
ENSG00000179674	ARL14	100	86.979	ENSPPRG00000021892	ARL14	100	86.979	Panthera_pardus
ENSG00000179674	ARL14	100	86.979	ENSPTIG00000007233	ARL14	100	86.979	Panthera_tigris_altaica
ENSG00000179674	ARL14	100	98.958	ENSPTRG00000048684	ARL14	100	98.958	Pan_troglodytes
ENSG00000179674	ARL14	100	96.875	ENSPANG00000014317	ARL14	100	96.875	Papio_anubis
ENSG00000179674	ARL14	100	67.188	ENSPSIG00000000950	ARL14	98	67.188	Pelodiscus_sinensis
ENSG00000179674	ARL14	99	78.125	ENSPEMG00000020737	Arl14	99	78.125	Peromyscus_maniculatus_bairdii
ENSG00000179674	ARL14	100	96.875	ENSPPYG00000014260	ARL14	100	96.875	Pongo_abelii
ENSG00000179674	ARL14	99	80.105	ENSPCAG00000004406	ARL14	99	80.105	Procavia_capensis
ENSG00000179674	ARL14	99	85.340	ENSPVAG00000004076	ARL14	99	85.340	Pteropus_vampyrus
ENSG00000179674	ARL14	99	77.083	ENSRNOG00000049827	Arl14	99	77.083	Rattus_norvegicus
ENSG00000179674	ARL14	100	97.917	ENSRROG00000028332	ARL14	100	97.917	Rhinopithecus_roxellana
ENSG00000179674	ARL14	100	69.792	ENSSHAG00000016852	ARL14	100	69.792	Sarcophilus_harrisii
ENSG00000179674	ARL14	98	70.745	ENSSPUG00000018772	ARL14	96	70.745	Sphenodon_punctatus
ENSG00000179674	ARL14	100	84.896	ENSSSCG00000011734	ARL14	100	84.896	Sus_scrofa
ENSG00000179674	ARL14	93	62.011	ENSTGUG00000011157	ARL14	94	62.011	Taeniopygia_guttata
ENSG00000179674	ARL14	99	87.368	ENSTBEG00000005473	ARL14	99	87.368	Tupaia_belangeri
ENSG00000179674	ARL14	92	86.441	ENSUAMG00000020459	ARL14	98	86.441	Ursus_americanus
ENSG00000179674	ARL14	92	85.876	ENSUMAG00000011131	ARL14	98	85.876	Ursus_maritimus
ENSG00000179674	ARL14	100	85.938	ENSVPAG00000008776	ARL14	100	85.938	Vicugna_pacos
ENSG00000179674	ARL14	100	64.062	ENSXETG00000008725	arl14	96	64.062	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	21458045.	IPI	Function
GO:0005525	GTP binding	21873635.	IBA	Function
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005886	plasma membrane	21873635.	IBA	Component
GO:0006886	intracellular protein transport	21873635.	IBA	Process
GO:0016192	vesicle-mediated transport	21873635.	IBA	Process
GO:0031410	cytoplasmic vesicle	-	IEA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.