EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
22797819	Pyrophosphatase overexpression is associated with cell migration, invasion, and poor prognosis in gastric cancer.	Tumour Biol	2012 Dec	Jeong SH	doi: 10.1007/s13277-012-0449-5
26722435	Inorganic pyrophosphatase (PPA1) is a negative prognostic marker for human gastric cancer.	Int J Clin Exp Pathol	2015 Oct 1	Yang Y	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr10	70209277	Missense_Mutation	novel	D218V	0.38
BLCA	chr10	70218780	Missense_Mutation	NA	S54C	0.44
BRCA	chr10	70218782	Missense_Mutation	NA	W53C	0.18
BRCA	chr10	70233320	Missense_Mutation	novel	G3D	0.17
BRCA	chr10	70209638	Missense_Mutation	rs766193453	V187M	0.06
BRCA	chr10	70209647	Missense_Mutation	NA	E184K	0.12
BRCA	chr10	70217874	Missense_Mutation	rs777717226	R79C	0.14
CESC	chr10	70217908	Silent	novel	N67N	0.11
CHOL	chr10	70218794	Silent	novel	E49E	0.16
COAD	chr10	70233373	5'UTR	novel		0.2
COAD	chr10	70217863	Silent	rs549996621	A82A	0.41
COAD	chr10	70213562	Missense_Mutation	rs146821187	V138M	0.33
COAD	chr10	70209229	Missense_Mutation	NA	K234R	0.23
GBM	chr10	70209590	Missense_Mutation	novel	E203K	0.22
HNSC	chr10	70214580	Nonsense_Mutation	novel	E102*	0.18
KIRC	chr10	70203033	3'UTR	novel		0.43
KIRP	chr10	70214531	Missense_Mutation	novel	D118G	0.23
LIHC	chr10	70203064	3'UTR	novel		0.25
LUAD	chr10	70206325	Missense_Mutation	novel	T245I	0.41
LUSC	chr10	70214512	Silent	NA	E124E	0.31
LUSC	chr10	70209573	Silent	NA	A208A	0.45
LUSC	chr10	70209663	Silent	novel	L178L	0.25
MESO	chr10	70209233	Missense_Mutation	novel	K233E	0.36
OV	chr10	70203116	3'UTR	rs200724078		0.07
OV	chr10	70213539	Silent	novel	A145A	0.23
SARC	chr10	70233374	5'UTR	novel		0.11
SKCM	chr10	70213525	Missense_Mutation	novel	G150E	0.46
SKCM	chr10	70213526	Missense_Mutation	novel	G150R	0.45
SKCM	chr10	70230358	Missense_Mutation	NA	P36S	0.94
STAD	chr10	70217811	Splice_Site	novel	X99_splice	0.11
STAD	chr10	70217823	Missense_Mutation	NA	A96T	0.15
STAD	chr10	70209266	Frame_Shift_Del	novel	*S222Afs9**	0.1
UCEC	chr10	70203146	3'UTR	novel		0.28
UCEC	chr10	70217863	Silent	rs549996621	A82A	0.49
UCEC	chr10	70209610	Missense_Mutation	novel	P196L	0.42
UCEC	chr10	70202981	3'UTR	novel		0.44
UCEC	chr10	70209623	Missense_Mutation	NA	R192W	0.5
UCEC	chr10	70213563	Silent	rs748397137	G137G	0.4
UCEC	chr10	70203087	3'UTR	novel		0.33
UCEC	chr10	70213474	Missense_Mutation	novel	A167V	0.29
UCEC	chr10	70213563	Silent	rs748397137	G137G	0.27
UCEC	chr10	70203148	3'UTR	novel		0.39
UCEC	chr10	70209583	Missense_Mutation	NA	A205V	0.22
UCEC	chr10	70213493	Missense_Mutation	rs141014375	V161M	0.41
UCEC	chr10	70214574	Missense_Mutation	novel	P104S	0.16
UCEC	chr10	70217874	Missense_Mutation	rs777717226	R79C	0.44
UCEC	chr10	70213591	Splice_Site	novel	X129_splice	0.34
UCEC	chr10	70209658	Missense_Mutation	NA	P180H	0.15
UCEC	chr10	70213541	Missense_Mutation	NA	A145T	0.27
UCEC	chr10	70209555	Splice_Region	novel		0.43

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1	0.19593
THCA	DEL	0.022	0.011063

Survival Analysis

Cancer	P-value	Q-value
MESO	0.028	Kaplan-Meier Survival Analysis
ACC	0.0033	Kaplan-Meier Survival Analysis
SKCM	0.00011	Kaplan-Meier Survival Analysis
ESCA	0.02	Kaplan-Meier Survival Analysis
COAD	0.015	Kaplan-Meier Survival Analysis
PAAD	0.011	Kaplan-Meier Survival Analysis
PCPG	0.023	Kaplan-Meier Survival Analysis
LAML	0.00094	Kaplan-Meier Survival Analysis
LIHC	0.017	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000180817 (Gene tree)
Gene ID: 5464
Gene Symbol: PPA1
Alias: SID6-8061|Ppase|IOPPP|PP1|PP
Full Name: pyrophosphatase (inorganic) 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 31,082 bases
Position: chr10:70,202,830-70,233,911
Accession: 9226
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a member of the inorganic pyrophosphatase (PPase) family. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Studies of a similar protein in bovine suggested a cytoplasmic localization of this enzyme. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
22750791	Wide range of interacting partners of pea Gβ subunit of G-proteins suggests its multiple functions in cell signalling.	Plant Physiol Biochem	2012 Sep	Bhardwaj D	doi: 10.1016/j.plaphy.2012.06.005

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000373232	PPA1-202	1295	-	ENSP00000362329	289 (aa)	-	Q15181
ENST00000373230	PPA1-201	787	-	ENSP00000362327	178 (aa)	-	Q5SQT6
ENST00000610026	PPA1-205	3524	-	-	- (aa)	-	-
ENST00000625364	PPA1-206	644	-	ENSP00000486162	178 (aa)	-	Q5SQT6
ENST00000495346	PPA1-204	282	-	-	- (aa)	-	-
ENST00000460755	PPA1-203	412	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000180817's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00190	Oxidative phosphorylation	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000180817	Tumor Necrosis Factor-alpha	8.98173037631952E-9	17903293

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000180817's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000180817	PPA1	97	55.172	YBR011C	IPP1	97	52.982	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000287	magnesium ion binding	-	IEA	Function
GO:0004427	inorganic diphosphatase activity	21873635.	IBA	Function
GO:0005737	cytoplasm	16130169.	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006418	tRNA aminoacylation for protein translation	-	TAS	Process
GO:0006796	phosphate-containing compound metabolic process	21873635.	IBA	Process
GO:0070062	extracellular exosome	20458337.	HDA	Component
GO:0071344	diphosphate metabolic process	-	TAS	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.