EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
29842882	Histone methyltransferase SETD2 regulates osteosarcoma cell growth and chemosensitivity by suppressing Wnt/β-catenin signaling.	Biochem Biophys Res Commun	2018 Jul 20	Jiang C	doi: 10.1016/j.bbrc.2018.05.176
20501857	Histone methyltransferase gene SETD2 is a novel tumor suppressor gene in clear cell renal cell carcinoma.	Cancer Res	2010 Jun 1	Duns G	doi: 10.1158/0008-5472.CAN-10-0120
24706662	SETD2 mutations cooperate with chromosomal aberrations in leukemia.	Cancer Discov	2014 Apr	-	doi: 10.1158/2159-8290.CD-RW2014-042
23644518	Aberrant promoter hypermethylation of PBRM1, BAP1, SETD2, KDM6A and other chromatin-modifying genes is absent or rare in clear cell RCC.	Epigenetics	2013 May	Ibragimova I	doi: 10.4161/epi.24552
28202515	Systematic In Vivo Inactivation of Chromatin-Regulating Enzymes Identifies Setd2 as a Potent Tumor Suppressor in Lung Adenocarcinoma.	Cancer Res	2017 Apr 1	Walter DM	doi: 10.1158/0008-5472.CAN-16-2159
28122867	The Genetic Basis of Hepatosplenic T-cell Lymphoma.	Cancer Discov	2017 Apr	McKinney M	doi: 10.1158/2159-8290.CD-16-0330
30660076	Expression and Mutation Patterns of PBRM1, BAP1 and SETD2 Mirror Specific Evolutionary Subtypes in Clear Cell Renal Cell Carcinoma.	Neoplasia	2019 Feb	Bihr S	doi: 10.1016/j.neo.2018.12.006
29522714	SETD2 indicates favourable prognosis in gastric cancer and suppresses cancer cell proliferation, migration, and invasion.	Biochem Biophys Res Commun	2018 Apr 6	Chen Z	doi: 10.1016/j.bbrc.2018.03.022
23620406	Adverse outcomes in clear cell renal cell carcinoma with mutations of 3p21 epigenetic regulators BAP1 and SETD2: a report by MSKCC and the KIRC TCGA research network.	Clin Cancer Res	2013 Jun 15	Hakimi AA	doi: 10.1158/1078-0432.CCR-12-3886
25728682	SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair.	Oncogene	2015 Nov 12	Kanu N	doi: 10.1038/onc.2015.24
19698110	The mRNA expression of SETD2 in human breast cancer: correlation with clinico-pathological parameters.	BMC Cancer	2009 Aug 21	Al Sarakbi W	doi: 10.1186/1471-2407-9-290.
26172293	LncRNA HOTAIR promotes human liver cancer stem cell malignant growth through downregulation of SETD2.	Oncotarget	2015 Sep 29	Li H	doi: 10.18632/oncotarget.4443.
24158655	Variation in chromatin accessibility in human kidney cancer links H3K36 methyltransferase loss with widespread RNA processing defects.	Genome Res	2014 Feb	Simon JM	doi: 10.1101/gr.158253.113
30093630	Acquired SETD2 mutation and impaired CREB1 activation confer cisplatin resistance in metastatic non-small cell lung cancer.	Oncogene	2019 Jan	Kim IK	doi: 10.1038/s41388-018-0429-3

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr3	47122804	Frame_Shift_Ins	novel	*K611Ifs27**	0.24
BLCA	chr3	47083870	Silent	novel	L1970L	0.36
BLCA	chr3	47120833	Missense_Mutation	rs773098323	S1268F	0.43
BLCA	chr3	47056910	Missense_Mutation	novel	Q2292E	0.53
BLCA	chr3	47106018	Silent	NA	F1606F	0.27
BLCA	chr3	47116723	Nonsense_Mutation	NA	R1496*	0.08
BLCA	chr3	47017098	Missense_Mutation	rs780004717	E2564K	0.28
BLCA	chr3	47062226	Missense_Mutation	NA	R2077Q	0.33
BLCA	chr3	47121539	Missense_Mutation	rs145759179	T1033A	0.48
BLCA	chr3	47057029	Missense_Mutation	novel	S2252F	0.24
BLCA	chr3	47101474	Nonsense_Mutation	NA	Q1667*	0.34
BLCA	chr3	47057000	Missense_Mutation	novel	P2262S	0.31
BLCA	chr3	47122472	Nonsense_Mutation	NA	Q722*	0.18
BLCA	chr3	47122957	Missense_Mutation	novel	S560L	0.16
BLCA	chr3	47120801	Missense_Mutation	NA	G1279R	0.33
BLCA	chr3	47113876	Missense_Mutation	rs750924110	S1572L	0.04
BLCA	chr3	47103378	Missense_Mutation	NA	H1629Y	0.2
BLCA	chr3	47120986	Missense_Mutation	novel	W1217L	0.08
BLCA	chr3	47120881	Missense_Mutation	NA	S1252L	0.11
BLCA	chr3	47113963	Missense_Mutation	rs752011468	R1543Q	0.36
BLCA	chr3	47121325	Missense_Mutation	novel	E1104G	0.15
BLCA	chr3	47056958	In_Frame_Ins	novel	S2275_N2276insDFLPYTRF	0.05
BLCA	chr3	47122697	Missense_Mutation	NA	D647N	0.13
BLCA	chr3	47101474	Nonsense_Mutation	NA	Q1667*	0.28
BLCA	chr3	47056892	Missense_Mutation	novel	Q2298E	0.16
BLCA	chr3	47084061	Missense_Mutation	novel	E1907Q	0.13
BLCA	chr3	47101457	Splice_Site	NA	X1672_splice	0.34
BLCA	chr3	47017104	Missense_Mutation	novel	E2562K	0.3
BLCA	chr3	47122502	Missense_Mutation	novel	K712E	0.27
BLCA	chr3	47083809	Nonsense_Mutation	NA	E1991*	0.49
BLCA	chr3	47120553	Missense_Mutation	novel	Q1361H	0.35
BLCA	chr3	47057180	Missense_Mutation	rs143083979	P2202A	0.26
BLCA	chr3	47116636	Missense_Mutation	novel	L1525V	0.2
BLCA	chr3	47046622	Splice_Site	novel	X2322_splice	0.26
BRCA	chr3	47088181	Missense_Mutation	NA	S1737G	0.37
BRCA	chr3	47042674	Silent	NA	L2375L	0.76
BRCA	chr3	47017702	Missense_Mutation	NA	R2490Q	0.18
BRCA	chr3	47124097	Nonsense_Mutation	NA	S180*	0.16
BRCA	chr3	47123197	Missense_Mutation	novel	Y480F	0.08
BRCA	chr3	47121533	Missense_Mutation	novel	H1035D	0.1
BRCA	chr3	47116708	Missense_Mutation	NA	C1501R	0.19
BRCA	chr3	47017175	Frame_Shift_Del	NA	*H2538Pfs26**	0.25
BRCA	chr3	47017246	Frame_Shift_Ins	NA	*H2514Qfs6**	0.12
BRCA	chr3	47123066	Missense_Mutation	NA	N524H	0.23
BRCA	chr3	47057429	Missense_Mutation	NA	E2119K	0.22
BRCA	chr3	47122783	Nonsense_Mutation	rs750437096	S618*	0.5
BRCA	chr3	47122876	Missense_Mutation	NA	S587C	0.45
BRCA	chr3	47116683	Missense_Mutation	NA	R1509T	0.38
BRCA	chr3	47123254	Nonsense_Mutation	novel	S461*	0.18
BRCA	chr3	47123422	Missense_Mutation	novel	S405C	0.09
BRCA	chr3	47103389	Missense_Mutation	NA	R1625L	0.43
BRCA	chr3	47122264	Nonsense_Mutation	novel	S791*	0.08
BRCA	chr3	47123624	Missense_Mutation	novel	D338H	0.1
BRCA	chr3	47067108	Missense_Mutation	NA	R2024Q	0.11
BRCA	chr3	47120923	Missense_Mutation	NA	S1238Y	0.13
BRCA	chr3	47122192	Nonsense_Mutation	NA	S815*	0.19
BRCA	chr3	47122503	Silent	NA	V711V	0.37
BRCA	chr3	47124326	Missense_Mutation	NA	P104S	0.24
BRCA	chr3	47121305	Missense_Mutation	novel	H1111N	0.1
BRCA	chr3	47121804	Silent	NA	A944A	0.18
BRCA	chr3	47120518	Missense_Mutation	novel	S1373I	0.09
BRCA	chr3	47122900	Missense_Mutation	NA	N579S	0.44
BRCA	chr3	47101469	Missense_Mutation	NA	F1668L	0.3
BRCA	chr3	47123100	Silent	novel	S512S	0.07
BRCA	chr3	47062270	Silent	novel	E2062E	0.11
CESC	chr3	47121914	Silent	novel	L908L	0.3
CESC	chr3	47123383	Missense_Mutation	novel	S418F	0.44
CESC	chr3	47056855	Nonsense_Mutation	novel	S2310*	0.5
CESC	chr3	47056945	Missense_Mutation	novel	V2280A	0.51
CESC	chr3	47120611	Missense_Mutation	novel	D1342V	0.33
CESC	chr3	47042621	Missense_Mutation	novel	P2393R	0.11
CESC	chr3	47120528	Missense_Mutation	novel	P1370T	0.77
CESC	chr3	47113958	Nonsense_Mutation	NA	Q1545*	0.73
CESC	chr3	47056963	Frame_Shift_Del	novel	*D2274Vfs35**	0.09
CESC	chr3	47056877	Missense_Mutation	novel	P2303S	0.27
CESC	chr3	47103408	Missense_Mutation	novel	Q1619E	0.11
CESC	chr3	47120884	Missense_Mutation	NA	S1251L	0.38
CESC	chr3	47017702	Missense_Mutation	NA	R2490Q	0.34
CESC	chr3	47121016	Missense_Mutation	NA	S1207C	0.58
CESC	chr3	47123190	Silent	novel	D482D	0.36
CESC	chr3	47121222	Silent	novel	E1138E	0.23
CESC	chr3	47122016	Missense_Mutation	NA	I874V	0.33
CESC	chr3	47122957	Missense_Mutation	novel	S560L	0.49
CESC	chr3	47017206	Missense_Mutation	novel	E2528Q	0.32
CHOL	chr3	47083744	Frame_Shift_Ins	novel	*L2013Pfs20**	0.56
COAD	chr3	47120449	Frame_Shift_Del	NA	*N1396Mfs16**	0.42
COAD	chr3	47019812	Missense_Mutation	novel	A2460V	0.13
COAD	chr3	47121936	Silent	rs370480746	C900C	0.29
COAD	chr3	47121634	Missense_Mutation	rs200816574	S1001C	0.08
COAD	chr3	47056921	Missense_Mutation	NA	P2288L	0.44
COAD	chr3	47123723	Frame_Shift_Del	NA	*T305Qfs35**	0.1
COAD	chr3	47113947	Silent	novel	Q1548Q	0.35
COAD	chr3	47122607	Missense_Mutation	rs764219907	P677S	0.14
COAD	chr3	47123959	Missense_Mutation	novel	P226L	0.39
COAD	chr3	47101519	Frame_Shift_Ins	NA	*T1652Yfs14**	0.26
COAD	chr3	47123723	Missense_Mutation	novel	T305A	0.25
COAD	chr3	47057138	Missense_Mutation	novel	P2216S	0.09
COAD	chr3	47019836	Missense_Mutation	rs775780402	S2452L	0.21
COAD	chr3	47123221	Missense_Mutation	rs201984344	R472H	0.43
COAD	chr3	47113875	Splice_Site	NA	X1572_splice	0.31
COAD	chr3	47067109	Nonsense_Mutation	NA	R2024*	0.37
COAD	chr3	47122312	Missense_Mutation	NA	V775G	0.35
COAD	chr3	47037742	Missense_Mutation	novel	P2425L	0.26
COAD	chr3	47019805	Silent	NA	T2462T	0.43
COAD	chr3	47019835	Silent	rs368025625	S2452S	0.47
COAD	chr3	47042661	Missense_Mutation	novel	P2380S	0.23
COAD	chr3	47120633	Missense_Mutation	NA	R1335C	0.26
COAD	chr3	47120417	Frame_Shift_Del	NA	*R1407Gfs5**	0.18
COAD	chr3	47084342	Frame_Shift_Del	NA	*N1813Ifs25**	0.32
COAD	chr3	47123431	Missense_Mutation	rs182736967	R402Q	0.42
COAD	chr3	47019803	Missense_Mutation	NA	S2463Y	0.1
COAD	chr3	47120422	Missense_Mutation	NA	K1405T	0.12
COAD	chr3	47121065	Missense_Mutation	NA	K1191Q	0.13
COAD	chr3	47121702	Missense_Mutation	NA	E978D	0.13
COAD	chr3	47103351	Missense_Mutation	novel	Q1638K	0.16
COAD	chr3	47106083	Missense_Mutation	NA	D1585N	0.33
COAD	chr3	47123723	Frame_Shift_Del	NA	*T305Qfs35**	0.39
COAD	chr3	47121132	Silent	novel	V1168V	0.4
COAD	chr3	47017164	Missense_Mutation	NA	E2542Q	0.17
COAD	chr3	47083745	Missense_Mutation	novel	L2012R	0.29
COAD	chr3	47057419	Missense_Mutation	NA	R2122Q	0.08
COAD	chr3	47116642	Missense_Mutation	NA	R1523C	0.26
COAD	chr3	47121106	Missense_Mutation	novel	K1177T	0.06
COAD	chr3	47124224	Nonsense_Mutation	novel	E138*	0.2
COAD	chr3	47046554	Missense_Mutation	NA	V2344A	0.29
COAD	chr3	47057342	In_Frame_Del	novel	G2145_S2148delinsA	0.06
COAD	chr3	47056912	Missense_Mutation	novel	S2291F	0.14
COAD	chr3	47083742	Missense_Mutation	novel	L2013P	0.62
ESCA	chr3	47123997	Silent	novel	A213A	0.24
ESCA	chr3	47057332	Missense_Mutation	novel	P2151L	0.62
ESCA	chr3	47113875	Splice_Site	novel	X1572_splice	0.36
GBM	chr3	47116662	Missense_Mutation	NA	C1516Y	0.37
GBM	chr3	47057012	Missense_Mutation	novel	P2258A	0.08
GBM	chr3	47084320	Silent	novel	V1820V	0.09
GBM	chr3	47017116	Missense_Mutation	novel	K2558E	0.08
GBM	chr3	47057188	Missense_Mutation	novel	S2199F	0.56
GBM	chr3	47121475	Missense_Mutation	novel	T1054R	0.04
GBM	chr3	47086271	Missense_Mutation	NA	H1774R	0.27
GBM	chr3	47017643	Missense_Mutation	NA	R2510C	0.32
GBM	chr3	47042601	Missense_Mutation	novel	D2400N	0.29
GBM	chr3	47062294	Silent	rs760543486	P2054P	0.23
GBM	chr3	47067108	Missense_Mutation	NA	R2024Q	0.09
GBM	chr3	47120636	Missense_Mutation	novel	D1334N	0.54
GBM	chr3	47122521	Silent	rs771398677	S705S	0.28
GBM	chr3	47056922	Missense_Mutation	novel	P2288S	0.1
GBM	chr3	47019782	Missense_Mutation	novel	S2470I	0.05
GBM	chr3	47057327	Missense_Mutation	novel	D2153N	0.04
GBM	chr3	47120210	Missense_Mutation	novel	I1476L	0.09
GBM	chr3	47017245	Missense_Mutation	novel	G2515S	0.35
GBM	chr3	47101543	Missense_Mutation	novel	G1644R	0.44
GBM	chr3	47121914	Missense_Mutation	novel	L908M	0.17
GBM	chr3	47122876	Missense_Mutation	novel	S587Y	0.26
GBM	chr3	47105995	Splice_Site	NA	X1613_splice	0.39
GBM	chr3	47121686	Missense_Mutation	novel	R984G	0.06
GBM	chr3	47017164	Missense_Mutation	NA	E2542K	0.48
GBM	chr3	47057419	Missense_Mutation	NA	R2122Q	0.41
GBM	chr3	47120472	Missense_Mutation	novel	D1388E	0.31
HNSC	chr3	47122187	Missense_Mutation	novel	M817L	0.43
HNSC	chr3	47037779	Splice_Site	NA	X2413_splice	0.28
HNSC	chr3	47122852	Missense_Mutation	novel	S595L	0.18
HNSC	chr3	47122068	Silent	rs775705122	I856I	0.25
HNSC	chr3	47106113	Missense_Mutation	novel	F1575I	0.34
HNSC	chr3	47122264	Nonsense_Mutation	novel	S791*	0.35
HNSC	chr3	47056977	Missense_Mutation	novel	N2269K	0.27
HNSC	chr3	47120717	Missense_Mutation	novel	D1307H	0.29
HNSC	chr3	47106028	Missense_Mutation	NA	H1603R	0.23
HNSC	chr3	47103422	Splice_Site	novel	X1614_splice	0.35
KICH	chr3	47042604	Nonsense_Mutation	NA	R2399*	0.24
KIRC	chr3	47120672	Nonsense_Mutation	NA	R1322*	0.48
KIRC	chr3	47084194	Frame_Shift_Del	novel	*K1863Sfs2**	0.27
KIRC	chr3	47122632	Frame_Shift_Del	novel	I669*	0.14
KIRC	chr3	47113970	Missense_Mutation	rs755382206	N1541H	0.5
KIRC	chr3	47122126	Missense_Mutation	novel	D837G	0.07
KIRC	chr3	47103390	Missense_Mutation	NA	R1625C	0.47
KIRC	chr3	47083890	Nonsense_Mutation	NA	E1964*	0.17
KIRC	chr3	47037779	Splice_Site	NA	X2413_splice	0.25
KIRC	chr3	47121719	Nonsense_Mutation	NA	R973*	0.3
KIRC	chr3	47122455	Nonsense_Mutation	NA	C727*	0.08
KIRC	chr3	47086246	Nonsense_Mutation	NA	W1782*	0.39
KIRC	chr3	47084315	Frame_Shift_Del	novel	*P1822Qfs16**	0.27
KIRC	chr3	47121056	Frame_Shift_Del	novel	*I1194Yfs42**	0.13
KIRC	chr3	47103378	Missense_Mutation	NA	H1629Y	0.24
KIRC	chr3	47101524	Missense_Mutation	NA	F1650S	0.4
KIRC	chr3	47123240	Nonsense_Mutation	NA	K466*	0.39
KIRC	chr3	47057413	Nonsense_Mutation	NA	L2124*	0.63
KIRC	chr3	47083770	Frame_Shift_Del	novel	*D2004Ifs2**	0.14
KIRC	chr3	47122852	Frame_Shift_Del	NA	*S595Kfs3**	0.35
KIRC	chr3	47098031	Nonsense_Mutation	novel	Y1688_L1689delins*	0.53
KIRC	chr3	47088232	Nonsense_Mutation	NA	E1720*	0.14
KIRC	chr3	47084301	Missense_Mutation	NA	W1827R	0.38
KIRC	chr3	47101553	Missense_Mutation	NA	W1640C	0.32
KIRC	chr3	47120181	Splice_Site	NA	X1485_splice	0.23
KIRC	chr3	47122783	Nonsense_Mutation	rs750437096	S618*	0.38
KIRC	chr3	47120534	Nonsense_Mutation	NA	Q1368*	0.16
KIRC	chr3	47120448	Frame_Shift_Del	novel	*I1377Mfs16**	0.51
KIRC	chr3	47120318	Frame_Shift_Del	novel	*S1437Rfs13**	0.08
KIRC	chr3	47124227	Nonsense_Mutation	novel	V137*	0.04
KIRC	chr3	47017155	Frame_Shift_Ins	novel	K2545*	0.19
KIRC	chr3	47019749	Splice_Site	novel	X2477_splice	0.2
KIRC	chr3	47101477	Missense_Mutation	NA	Y1666H	0.39
KIRC	chr3	47042678	Frame_Shift_Del	NA	*T2372Sfs54**	0.42
KIRC	chr3	47019752	Splice_Site	novel	X2475_splice	0.24
KIRC	chr3	47121297	Nonsense_Mutation	NA	Y1113*	0.38
KIRC	chr3	47122500	Frame_Shift_Del	NA	*S708Hfs54**	0.29
KIRC	chr3	47123008	Nonsense_Mutation	NA	S543*	0.53
KIRC	chr3	47056922	Frame_Shift_Ins	novel	*P2288Ifs22**	0.23
KIRC	chr3	47123771	Frame_Shift_Del	novel	*D289Mfs12**	0.47
KIRC	chr3	47122307	Nonsense_Mutation	NA	E777*	0.1
KIRC	chr3	47122957	Nonsense_Mutation	NA	S560*	0.26
KIRC	chr3	47116625	Missense_Mutation	NA	E1528D	0.41
KIRC	chr3	47017657	Frame_Shift_Del	novel	D2504*	0.21
KIRC	chr3	47086247	Nonsense_Mutation	NA	W1782*	0.07
KIRC	chr3	47123123	Nonsense_Mutation	NA	E505*	0.16
KIRC	chr3	47017642	Missense_Mutation	NA	R2510H	0.32
KIRP	chr3	47103380	Missense_Mutation	novel	N1628T	0.57
KIRP	chr3	47122624	Frame_Shift_Del	novel	L671*	0.84
KIRP	chr3	47123793	Frame_Shift_Del	novel	*E282Ifs18**	0.71
KIRP	chr3	47123900	Frame_Shift_Ins	novel	*V246Cfs10**	0.61
KIRP	chr3	47086288	Missense_Mutation	NA	K1768N	0.4
KIRP	chr3	47163931	5'UTR	novel		0.08
KIRP	chr3	47019786	Nonsense_Mutation	NA	K2469*	0.86
KIRP	chr3	47121359	Frame_Shift_Del	novel	*S1093Lfs2**	0.88
KIRP	chr3	47122886	Frame_Shift_Ins	novel	*Q584Tfs6**	0.78
KIRP	chr3	47101557	Splice_Site	NA	X1640_splice	0.76
KIRP	chr3	47084152	Frame_Shift_Ins	novel	*M1877Nfs10**	0.79
KIRP	chr3	47120261	Frame_Shift_Del	novel	*P1457Dfs24**	0.56
KIRP	chr3	47116707	Missense_Mutation	NA	C1501S	0.56
KIRP	chr3	47122476	Frame_Shift_Ins	novel	*F721Ifs5**	0.83
KIRP	chr3	47122063	Missense_Mutation	novel	S858T	0.35
KIRP	chr3	47037770	Nonsense_Mutation	novel	Q2416*	0.58
KIRP	chr3	47057369	Frame_Shift_Del	novel	*Q2139Nfs8**	0.75
KIRP	chr3	47057370	Silent	rs776824718	Q2138Q	0.75
KIRP	chr3	47121402	Frame_Shift_Del	novel	*L1078Ffs43**	0.87
LAML	chr3	47083803	Missense_Mutation	novel	E1993K	0.05
LAML	chr3	47084159	Missense_Mutation	novel	K1874M	0.07
LAML	chr3	47083748	In_Frame_Ins	novel	K2011delinsTQ	0.5
LAML	chr3	47083749	Frame_Shift_Ins	novel	K2011*	0.5
LGG	chr3	47120415	Frame_Shift_Del	novel	*R1408Gfs4**	0.17
LGG	chr3	47120398	Frame_Shift_Del	rs771527963	*E1412Vfs19**	0.21
LGG	chr3	47056910	Nonsense_Mutation	NA	Q2292*	0.12
LGG	chr3	47046544	Frame_Shift_Ins	novel	*Q2347Hfs23**	0.5
LGG	chr3	47106028	Missense_Mutation	NA	H1603R	0.17
LGG	chr3	47103390	Missense_Mutation	NA	R1625C	0.1
LGG	chr3	47084232	Missense_Mutation	rs376063996	R1850C	0.09
LGG	chr3	47113904	Missense_Mutation	NA	G1563R	0.33
LGG	chr3	47120295	Silent	novel	P1447P	0.06
LGG	chr3	47121886	Frame_Shift_Ins	novel	*S917Kfs18**	0.34
LGG	chr3	47122285	Missense_Mutation	novel	S784Y	0.11
LGG	chr3	47062178	Frame_Shift_Del	novel	*L2081Kfs4**	0.2
LGG	chr3	47101519	Missense_Mutation	novel	T1652P	0.25
LGG	chr3	47062277	Nonsense_Mutation	NA	S2060*	0.05
LIHC	chr3	47120180	Splice_Site	novel	X1485_splice	0.58
LIHC	chr3	47088127	Missense_Mutation	novel	L1755V	0.28
LIHC	chr3	47057431	Missense_Mutation	NA	T2118I	0.27
LIHC	chr3	47042701	Splice_Site	novel	X2367_splice	0.36
LIHC	chr3	47056881	Silent	rs774810866	T2301T	0.28
LIHC	chr3	47124316	Missense_Mutation	novel	P107L	0.2
LIHC	chr3	47120376	Silent	novel	E1420E	0.2
LIHC	chr3	47120905	Missense_Mutation	rs768083138	P1244L	0.1
LIHC	chr3	47046618	Missense_Mutation	novel	Y2323D	0.29
LIHC	chr3	47121858	Frame_Shift_Del	novel	*E927Kfs3**	0.46
LIHC	chr3	47121569	Missense_Mutation	NA	S1023G	0.34
LIHC	chr3	47114003	Missense_Mutation	NA	S1530T	0.07
LIHC	chr3	47123735	Missense_Mutation	novel	S301C	0.4
LIHC	chr3	47123239	Missense_Mutation	NA	K466R	0.48
LIHC	chr3	47120260	Frame_Shift_Ins	novel	*R1459Qfs26**	0.29
LIHC	chr3	47120571	Silent	novel	K1355K	0.33
LIHC	chr3	47113875	Splice_Site	NA	X1572_splice	0.28
LIHC	chr3	47016859	3'UTR	novel		0.38
LUAD	chr3	47056833	Silent	NA	P2317P	0.65
LUAD	chr3	47120983	Missense_Mutation	NA	Q1218P	0.14
LUAD	chr3	47101474	Nonsense_Mutation	NA	Q1667*	0.07
LUAD	chr3	47113969	Missense_Mutation	NA	N1541S	0.28
LUAD	chr3	47120368	Frame_Shift_Ins	novel	*D1423Gfs6**	0.12
LUAD	chr3	47122855	Frame_Shift_Del	novel	*T592Ifs7**	0.07
LUAD	chr3	47123016	Frame_Shift_Del	novel	*R540Pfs7**	0.63
LUAD	chr3	47062248	Nonsense_Mutation	NA	Q2070*	0.15
LUAD	chr3	47116707	Missense_Mutation	NA	C1501S	0.19
LUAD	chr3	47062257	Nonsense_Mutation	NA	K2067*	0.29
LUAD	chr3	47103392	Missense_Mutation	novel	S1624C	0.22
LUAD	chr3	47122073	Missense_Mutation	NA	S855C	0.38
LUAD	chr3	47101519	Frame_Shift_Ins	NA	*T1652Yfs14**	0.31
LUAD	chr3	47057029	Missense_Mutation	novel	S2252C	0.15
LUAD	chr3	47103390	Missense_Mutation	NA	R1625C	0.16
LUAD	chr3	47037779	Splice_Site	NA	X2413_splice	0.33
LUAD	chr3	47088140	Missense_Mutation	novel	Q1750H	0.09
LUAD	chr3	47120704	Missense_Mutation	novel	G1311D	0.07
LUAD	chr3	47121449	Nonsense_Mutation	NA	R1063*	0.12
LUAD	chr3	47116659	Missense_Mutation	NA	G1517V	0.42
LUAD	chr3	47122923	Frame_Shift_Ins	novel	*N571Kfs10**	0.13
LUAD	chr3	47046501	Missense_Mutation	NA	Q2362E	0.59
LUAD	chr3	47121257	Missense_Mutation	NA	Q1127E	0.67
LUAD	chr3	47123005	Missense_Mutation	NA	S544L	0.59
LUAD	chr3	47120639	Missense_Mutation	novel	D1333Y	0.21
LUAD	chr3	47122797	Frame_Shift_Del	novel	*S614Lfs8**	0.2
LUAD	chr3	47103389	Missense_Mutation	NA	R1625H	0.3
LUAD	chr3	47084331	Nonsense_Mutation	novel	E1817*	0.19
LUAD	chr3	47116662	Missense_Mutation	NA	C1516F	0.11
LUAD	chr3	47121971	Nonsense_Mutation	novel	S881_G889delins*	0.07
LUAD	chr3	47046539	Missense_Mutation	NA	A2349G	0.21
LUAD	chr3	47120881	Nonsense_Mutation	NA	S1252*	0.22
LUAD	chr3	47116657	Nonsense_Mutation	NA	E1518*	0.44
LUAD	chr3	47042682	Missense_Mutation	novel	N2373D	0.39
LUAD	chr3	47056831	Missense_Mutation	novel	P2318L	0.41
LUAD	chr3	47057013	Silent	novel	L2257L	0.23
LUAD	chr3	47057390	Frame_Shift_Ins	novel	*R2132Tfs22**	0.28
LUAD	chr3	47121871	Frame_Shift_Del	novel	*K922Sfs8**	0.35
LUAD	chr3	47120180	Splice_Site	novel	X1485_splice	0.29
LUAD	chr3	47017216	Nonsense_Mutation	novel	C2524*	0.31
LUAD	chr3	47120672	Nonsense_Mutation	NA	R1322*	0.26
LUAD	chr3	47120300	Missense_Mutation	NA	G1446W	0.48
LUAD	chr3	47057422	Missense_Mutation	novel	R2121L	0.09
LUAD	chr3	47057483	Frame_Shift_Del	novel	*D2100Tfs4**	0.18
LUAD	chr3	47120985	Nonsense_Mutation	NA	W1217*	0.25
LUAD	chr3	47116735	Nonsense_Mutation	NA	R1492*	0.43
LUAD	chr3	47120186	Nonsense_Mutation	NA	E1484*	0.17
LUAD	chr3	47084161	Frame_Shift_Del	novel	*K1874Rfs3**	0.15
LUAD	chr3	47113987	Frame_Shift_Del	novel	*N1535Wfs7**	0.16
LUSC	chr3	47084240	Missense_Mutation	novel	N1847S	0.49
LUSC	chr3	47083734	Missense_Mutation	NA	W2016R	0.39
LUSC	chr3	47121267	Silent	novel	K1123K	0.3
LUSC	chr3	47056980	Missense_Mutation	novel	Q2268H	0.14
LUSC	chr3	47088124	Nonsense_Mutation	NA	E1756*	0.33
LUSC	chr3	47120731	Missense_Mutation	novel	G1302D	0.19
LUSC	chr3	47103389	Missense_Mutation	NA	R1625H	0.8
LUSC	chr3	47123254	Nonsense_Mutation	novel	S461*	0.44
LUSC	chr3	47098041	Silent	novel	R1686R	0.07
LUSC	chr3	47116713	Missense_Mutation	novel	C1499F	0.78
LUSC	chr3	47037749	Frame_Shift_Del	novel	*E2423Kfs27**	0.3
LUSC	chr3	47083845	Missense_Mutation	novel	P1979A	0.65
LUSC	chr3	47042691	Missense_Mutation	NA	V2370F	0.78
LUSC	chr3	47088113	Missense_Mutation	novel	Q1759H	0.47
LUSC	chr3	47106055	Missense_Mutation	novel	K1594R	0.91
LUSC	chr3	47088124	Nonsense_Mutation	NA	E1756*	0.4
MESO	chr3	47088132	Frame_Shift_Ins	novel	*T1753Nfs36**	0.73
MESO	chr3	47120884	Nonsense_Mutation	novel	S1251*	0.26
MESO	chr3	47121667	Missense_Mutation	novel	V990G	0.27
MESO	chr3	47057360	Nonsense_Mutation	novel	Q2142*	0.34
MESO	chr3	47120777	Nonsense_Mutation	novel	Q1287*	0.21
MESO	chr3	47057069	Nonsense_Mutation	novel	Q2239*	0.82
MESO	chr3	47101507	Missense_Mutation	novel	V1656F	0.15
OV	chr3	47084381	Missense_Mutation	NA	I1800N	0.27
OV	chr3	47121646	Frame_Shift_Del	novel	*E997Sfs7**	0.06
OV	chr3	47056826	Missense_Mutation	novel	V2320L	0.17
OV	chr3	47121689	Nonsense_Mutation	NA	E983*	0.21
OV	chr3	47084050	Missense_Mutation	novel	D1910E	0.06
OV	chr3	47017186	Missense_Mutation	novel	E2534D	0.28
OV	chr3	47098001	Missense_Mutation	NA	A1699V	0.45
OV	chr3	47121689	Frame_Shift_Del	novel	*E983Kfs23**	0.1
OV	chr3	47101497	Missense_Mutation	NA	G1659V	0.36
OV	chr3	47057256	Nonsense_Mutation	NA	Y2176*	0.48
OV	chr3	47057195	Missense_Mutation	NA	V2197L	0.13
OV	chr3	47124027	Silent	novel	S203S	0.11
PAAD	chr3	47084144	Missense_Mutation	novel	R1879H	0.04
PCPG	chr3	47062346	Missense_Mutation	novel	T2037R	0.38
PCPG	chr3	47116671	Missense_Mutation	novel	E1513V	0.05
PRAD	chr3	47042655	Frame_Shift_Ins	novel	*S2382Lfs47**	0.23
PRAD	chr3	47120390	Nonsense_Mutation	novel	E1416*	0.3
PRAD	chr3	47083784	Missense_Mutation	novel	P1999R	0.38
PRAD	chr3	47086227	Frame_Shift_Del	novel	*D1788Pfs4**	0.4
PRAD	chr3	47062338	Nonsense_Mutation	NA	R2040*	0.05
PRAD	chr3	47103418	Missense_Mutation	novel	I1615M	0.05
PRAD	chr3	47121964	Missense_Mutation	NA	K891M	0.14
PRAD	chr3	47084144	Missense_Mutation	novel	R1879H	0.41
READ	chr3	47121414	Missense_Mutation	rs757432733	K1074N	0.29
READ	chr3	47123981	Missense_Mutation	NA	I219L	0.2
READ	chr3	47122960	Missense_Mutation	novel	L559P	0.06
READ	chr3	47084280	Missense_Mutation	rs760392790	V1834I	0.36
READ	chr3	47124247	Missense_Mutation	rs550723354	S130Y	0.29
READ	chr3	47017130	Frame_Shift_Ins	novel	*A2553Gfs10**	0.25
READ	chr3	47121359	Missense_Mutation	NA	S1093R	0.24
READ	chr3	47088157	Missense_Mutation	novel	I1745V	0.43
READ	chr3	47057458	Missense_Mutation	NA	R2109Q	0.43
READ	chr3	47116641	Missense_Mutation	novel	R1523H	0.4
READ	chr3	47120474	Missense_Mutation	rs779295786	D1388Y	0.38
READ	chr3	47123087	Nonsense_Mutation	NA	E517*	0.4
READ	chr3	47088232	Missense_Mutation	novel	E1720K	0.08
READ	chr3	47120954	Missense_Mutation	NA	S1228G	0.18
READ	chr3	47124478	Missense_Mutation	rs745499104	R53Q	0.08
SARC	chr3	47123269	Missense_Mutation	rs777476264	R456Q	0.33
SARC	chr3	47120559	Silent	novel	S1359S	0.38
SKCM	chr3	47122367	Nonsense_Mutation	NA	Q757*	0.31
SKCM	chr3	47120633	Missense_Mutation	NA	R1335C	0.3
SKCM	chr3	47042661	Missense_Mutation	NA	P2380A	0.25
SKCM	chr3	47120830	Missense_Mutation	NA	T1269I	0.31
SKCM	chr3	47083872	Silent	NA	L1970L	0.23
SKCM	chr3	47121019	Missense_Mutation	NA	S1206F	0.44
SKCM	chr3	47120821	Missense_Mutation	NA	Q1272P	0.12
SKCM	chr3	47101531	Missense_Mutation	novel	V1648F	0.23
SKCM	chr3	47121400	Missense_Mutation	rs778145277	P1079L	0.34
SKCM	chr3	47057036	Nonsense_Mutation	NA	Q2250*	0.47
SKCM	chr3	47084133	Missense_Mutation	novel	I1883F	0.27
SKCM	chr3	47123108	Missense_Mutation	novel	Y510H	0.3
SKCM	chr3	47106080	Missense_Mutation	NA	H1586Y	0.13
SKCM	chr3	47121986	Nonsense_Mutation	NA	Q884*	0.19
SKCM	chr3	47017209	Missense_Mutation	NA	P2527S	0.42
SKCM	chr3	47116735	Nonsense_Mutation	NA	R1492*	0.38
SKCM	chr3	47120592	Missense_Mutation	novel	H1348Q	0.32
SKCM	chr3	47083844	Missense_Mutation	NA	P1979L	0.23
SKCM	chr3	47042604	Nonsense_Mutation	NA	R2399*	0.36
SKCM	chr3	47088201	Missense_Mutation	NA	S1730F	0.09
SKCM	chr3	47122361	Missense_Mutation	rs200479097	K759E	0.37
SKCM	chr3	47103378	Missense_Mutation	NA	H1629Y	0.15
SKCM	chr3	47122816	Missense_Mutation	novel	P607L	0.38
SKCM	chr3	47122890	Silent	NA	I582I	0.7
SKCM	chr3	47113973	Missense_Mutation	NA	S1540P	0.23
STAD	chr3	47097960	Missense_Mutation	NA	D1713Y	0.35
STAD	chr3	47121937	Missense_Mutation	NA	C900Y	0.43
STAD	chr3	47042656	Frame_Shift_Del	NA	*S2382Lfs29**	0.18
STAD	chr3	47120755	Missense_Mutation	NA	G1294D	0.2
STAD	chr3	47120416	Frame_Shift_Ins	novel	*R1407Kfs8**	0.33
STAD	chr3	47057340	Silent	NA	S2148S	0.11
STAD	chr3	47062264	Frame_Shift_Ins	rs749901643	*D2064Efs84**	0.42
STAD	chr3	47057390	Missense_Mutation	rs769623377	R2132W	0.13
STAD	chr3	47084379	Missense_Mutation	NA	I1801V	0.24
STAD	chr3	47123017	Missense_Mutation	rs371758386	R540Q	0.34
STAD	chr3	47062226	Missense_Mutation	NA	R2077Q	0.16
STAD	chr3	47084234	Missense_Mutation	NA	S1849L	0.43
STAD	chr3	47121187	Missense_Mutation	novel	R1150I	0.1
STAD	chr3	47062176	Frame_Shift_Del	NA	*R2094Gfs53**	0.16
STAD	chr3	47084294	Missense_Mutation	novel	Q1829P	0.41
STAD	chr3	47046508	Silent	novel	G2359G	0.41
STAD	chr3	47122975	Missense_Mutation	rs375514539	R554H	0.08
STAD	chr3	47101456	Splice_Site	NA	X1672_splice	0.24
STAD	chr3	47106061	Missense_Mutation	NA	R1592Q	0.26
STAD	chr3	47113969	Missense_Mutation	NA	N1541S	0.29
STAD	chr3	47086203	Nonsense_Mutation	novel	Q1797*	0.29
STAD	chr3	47121469	Missense_Mutation	rs776300341	S1056L	0.27
STAD	chr3	47057304	Silent	rs368137896	P2160P	0.15
STAD	chr3	47057033	Missense_Mutation	NA	D2251H	0.26
STAD	chr3	47101519	Frame_Shift_Ins	NA	*T1652Yfs14**	0.36
STAD	chr3	47120417	Frame_Shift_Del	NA	*R1407Gfs5**	0.23
STAD	chr3	47122782	Silent	NA	S618S	0.13
STAD	chr3	47120417	Frame_Shift_Del	NA	*R1407Gfs5**	0.25
THCA	chr3	47121222	Missense_Mutation	NA	E1138D	0.05
THCA	chr3	47057142	Frame_Shift_Del	novel	*E2215Nfs33**	0.1
THYM	chr3	47101470	Missense_Mutation	novel	F1668S	0.39
UCEC	chr3	47057209	Missense_Mutation	NA	P2192H	0.49
UCEC	chr3	47120786	Missense_Mutation	novel	H1284N	0.25
UCEC	chr3	47122633	Missense_Mutation	NA	P668L	0.38
UCEC	chr3	47019835	Silent	rs368025625	S2452S	0.33
UCEC	chr3	47084234	Missense_Mutation	NA	S1849L	0.33
UCEC	chr3	47122085	Nonsense_Mutation	NA	E851*	0.31
UCEC	chr3	47057458	Missense_Mutation	NA	R2109Q	0.28
UCEC	chr3	47067080	Frame_Shift_Ins	novel	*E2034Gfs6**	0.32
UCEC	chr3	47086315	Splice_Site	NA	X1760_splice	0.37
UCEC	chr3	47016518	3'Flank	novel		0.15
UCEC	chr3	47120232	Missense_Mutation	novel	K1468N	0.33
UCEC	chr3	47122898	Nonsense_Mutation	NA	E580*	0.23
UCEC	chr3	47121144	Missense_Mutation	novel	Q1164H	0.47
UCEC	chr3	47056938	Silent	NA	V2282V	0.19
UCEC	chr3	47062237	Missense_Mutation	novel	E2073D	0.05
UCEC	chr3	47120671	Missense_Mutation	rs147170912	R1322Q	0.06
UCEC	chr3	47120910	Missense_Mutation	NA	E1242D	0.51
UCEC	chr3	47123341	Missense_Mutation	rs762208680	R432H	0.49
UCEC	chr3	47084117	Missense_Mutation	novel	S1888N	0.11
UCEC	chr3	47123018	Nonsense_Mutation	rs201756643	R540*	0.32
UCEC	chr3	47123119	Missense_Mutation	novel	R506I	0.26
UCEC	chr3	47123600	Nonsense_Mutation	novel	E346*	0.2
UCEC	chr3	47121704	Nonsense_Mutation	novel	E978*	0.08
UCEC	chr3	47084087	Missense_Mutation	novel	S1898N	0.07
UCEC	chr3	47121228	Silent	NA	G1136G	0.44
UCEC	chr3	47122721	Missense_Mutation	rs761234986	E639K	0.45
UCEC	chr3	47124300	Silent	novel	S112S	0.07
UCEC	chr3	47056970	Missense_Mutation	novel	V2272I	0.2
UCEC	chr3	47122382	Silent	novel	L752L	0.42
UCEC	chr3	47016951	3'UTR	novel		0.25
UCEC	chr3	47121857	Nonsense_Mutation	novel	E927*	0.24
UCEC	chr3	47046533	Missense_Mutation	novel	A2351E	0.11
UCEC	chr3	47067108	Missense_Mutation	NA	R2024Q	0.39
UCEC	chr3	47086275	Missense_Mutation	rs758473163	R1773C	0.5
UCEC	chr3	47120204	Nonsense_Mutation	NA	E1478*	0.28
UCEC	chr3	47097969	Missense_Mutation	NA	R1710C	0.35
UCEC	chr3	47121414	Missense_Mutation	rs757432733	K1074N	0.26
UCEC	chr3	47017221	Missense_Mutation	NA	Y2523H	0.14
UCEC	chr3	47120781	Missense_Mutation	novel	K1285N	0.07
UCEC	chr3	47123462	Nonsense_Mutation	novel	*S391_S392insKEVSVLQ**	0.11
UCEC	chr3	47123462	Frame_Shift_Ins	novel	*S392Lfs101**	0.09
UCEC	chr3	47017687	Missense_Mutation	NA	K2495T	0.23
UCEC	chr3	47106006	Missense_Mutation	NA	K1610N	0.19
UCEC	chr3	47120204	Nonsense_Mutation	NA	E1478*	0.24
UCEC	chr3	47123067	Missense_Mutation	NA	E523D	0.31
UCEC	chr3	47123810	Missense_Mutation	novel	D276N	0.07
UCEC	chr3	47120456	Missense_Mutation	novel	E1394Q	0.48
UCEC	chr3	47062226	Missense_Mutation	NA	R2077Q	0.32
UCEC	chr3	47113912	Missense_Mutation	NA	K1560R	0.29
UCEC	chr3	47042676	Missense_Mutation	novel	L2375I	0.21
UCEC	chr3	47123455	Missense_Mutation	novel	C394Y	0.28
UCEC	chr3	47121123	Silent	novel	T1171T	0.43
UCEC	chr3	47086300	Missense_Mutation	novel	Q1764H	0.28
UCEC	chr3	47122601	Missense_Mutation	novel	A679T	0.3
UCEC	chr3	47019836	Missense_Mutation	rs775780402	S2452L	0.5
UCEC	chr3	47103360	Missense_Mutation	novel	C1635R	0.44
UCEC	chr3	47123723	Frame_Shift_Del	NA	*T305Qfs35**	0.53
UCEC	chr3	47123485	Missense_Mutation	novel	E384V	0.13
UCEC	chr3	47123486	Frame_Shift_Ins	novel	*E384Pfs15**	0.13
UCEC	chr3	47016450	3'Flank	novel		0.24
UCEC	chr3	47017111	Silent	novel	E2559E	0.42
UCEC	chr3	47121414	Missense_Mutation	rs757432733	K1074N	0.44
UCEC	chr3	47123170	Missense_Mutation	novel	S489Y	0.31
UCEC	chr3	47016458	3'Flank	novel		0.12
UCEC	chr3	47067098	Missense_Mutation	novel	K2027N	0.34
UCEC	chr3	47123017	Missense_Mutation	rs371758386	R540Q	0.24
UCEC	chr3	47124478	Missense_Mutation	rs745499104	R53Q	0.16
UCEC	chr3	47016860	3'UTR	novel		0.45
UCEC	chr3	47056879	Missense_Mutation	novel	C2302Y	0.21
UCEC	chr3	47098074	Missense_Mutation	novel	A1675T	0.43
UCEC	chr3	47121360	Silent	rs114327122	Q1092Q	0.22
UCEC	chr3	47123303	Missense_Mutation	novel	R445C	0.3
UCEC	chr3	47123305	Missense_Mutation	novel	T444M	0.32
UCEC	chr3	47016799	3'UTR	novel		0.32
UCEC	chr3	47084233	Silent	rs750812600	S1849S	0.39
UCEC	chr3	47106083	Missense_Mutation	NA	D1585N	0.26
UCEC	chr3	47121307	Missense_Mutation	novel	R1110K	0.29
UCEC	chr3	47121468	Silent	rs768944836	S1056S	0.31
UCEC	chr3	47116722	Missense_Mutation	NA	R1496Q	0.16
UCEC	chr3	47057446	Missense_Mutation	novel	R2113H	0.41
UCEC	chr3	47122628	Nonsense_Mutation	novel	E670*	0.38
UCEC	chr3	47122822	Missense_Mutation	novel	K605T	0.07
UCEC	chr3	47067108	Missense_Mutation	NA	R2024P	0.36
UCEC	chr3	47084322	Missense_Mutation	novel	V1820L	0.1
UCEC	chr3	47080863	Intron	novel		0.27
UCEC	chr3	47016497	3'Flank	novel		0.39
UCEC	chr3	47123243	Missense_Mutation	novel	Y465H	0.15
UCEC	chr3	47017113	Nonsense_Mutation	novel	E2559*	0.51
UCEC	chr3	47042654	Missense_Mutation	novel	S2382Y	0.56
UCEC	chr3	47062179	Missense_Mutation	novel	K2093Q	0.56
UCEC	chr3	47123533	Missense_Mutation	novel	R368Q	0.26
UCEC	chr3	47123723	Frame_Shift_Del	NA	*T305Qfs35**	0.34
UCEC	chr3	47019805	Silent	NA	T2462T	0.11
UCEC	chr3	47016438	3'Flank	novel		0.34
UCEC	chr3	47121857	Nonsense_Mutation	novel	E927*	0.43
UCEC	chr3	47123050	Missense_Mutation	NA	R529I	0.33
UCEC	chr3	47016796	3'UTR	novel		0.26
UCEC	chr3	47017178	Missense_Mutation	novel	K2537R	0.29
UCEC	chr3	47042576	Missense_Mutation	novel	Y2408C	0.09
UCEC	chr3	47106050	Missense_Mutation	novel	Y1596H	0.33
UCEC	chr3	47121354	Silent	rs774952312	Y1094Y	0.41
UCEC	chr3	47120633	Missense_Mutation	NA	R1335C	0.41
UCEC	chr3	47120449	Frame_Shift_Del	NA	*N1396Mfs16**	0.34
UCEC	chr3	47124279	In_Frame_Ins	novel	E119delinsDSGTII	0.07
UCEC	chr3	47057458	Missense_Mutation	NA	R2109Q	0.2
UCEC	chr3	47121083	Missense_Mutation	novel	N1185H	0.23
UCEC	chr3	47124066	Silent	rs752167577	P190P	0.1
UCEC	chr3	47101504	Missense_Mutation	NA	P1657S	0.03
UCEC	chr3	47122059	Silent	novel	T859T	0.62
UCEC	chr3	47042656	Frame_Shift_Del	NA	*S2382Lfs29**	0.4
UCEC	chr3	47016772	3'UTR	novel		0.36
UCEC	chr3	47062226	Missense_Mutation	NA	R2077Q	0.3
UCEC	chr3	47086227	Missense_Mutation	rs759310174	G1789S	0.29
UCEC	chr3	47121469	Missense_Mutation	rs776300341	S1056L	0.42
UCEC	chr3	47124300	Silent	novel	S112S	0.39
UCEC	chr3	47017672	Missense_Mutation	novel	T2500I	0.27
UCEC	chr3	47057188	Missense_Mutation	novel	S2199Y	0.34
UCEC	chr3	47121113	Missense_Mutation	novel	D1175Y	0.34
UCEC	chr3	47123533	Missense_Mutation	novel	R368Q	0.36
UCEC	chr3	47067109	Nonsense_Mutation	NA	R2024*	0.33
UCEC	chr3	47084158	Silent	novel	K1874K	0.44
UCEC	chr3	47121442	Missense_Mutation	rs745925708	R1065H	0.33
UCEC	chr3	47084303	Missense_Mutation	NA	R1826H	0.29
UCEC	chr3	47106043	Missense_Mutation	novel	R1598Q	0.05
UCEC	chr3	47120456	Nonsense_Mutation	NA	E1394*	0.23
UCEC	chr3	47121359	Missense_Mutation	NA	S1093R	0.05
UCEC	chr3	47123087	Nonsense_Mutation	NA	E517*	0.36
UCEC	chr3	47016438	3'Flank	novel		0.18
UCEC	chr3	47017211	Missense_Mutation	novel	N2526T	0.17
UCEC	chr3	47017654	Missense_Mutation	novel	K2506T	0.11
UCEC	chr3	47084158	Missense_Mutation	novel	K1874N	0.32
UCEC	chr3	47123142	Missense_Mutation	novel	E498D	0.15
UCEC	chr3	47017675	Missense_Mutation	novel	I2499T	0.25
UCEC	chr3	47084303	Missense_Mutation	NA	R1826H	0.24
UCEC	chr3	47086288	Missense_Mutation	NA	K1768N	0.12
UCEC	chr3	47120417	Frame_Shift_Del	NA	*R1407Gfs5**	0.38
UCEC	chr3	47084303	Missense_Mutation	NA	R1826H	0.38
UCEC	chr3	47121529	Missense_Mutation	NA	E1036A	0.13
UCEC	chr3	47086274	Missense_Mutation	rs750518294	R1773H	0.48
UCEC	chr3	47083862	Missense_Mutation	novel	P1973H	0.36
UCEC	chr3	47124210	Frame_Shift_Ins	novel	*H143Ffs10**	0.04
UCEC	chr3	47116701	Missense_Mutation	NA	P1503L	0.29
UCEC	chr3	47101520	Frame_Shift_Del	rs759274882	*F1651Lfs12**	0.26
UCEC	chr3	47083761	Missense_Mutation	NA	D2007Y	0.45
UCEC	chr3	47122721	Missense_Mutation	rs761234986	E639K	0.4
UCEC	chr3	47120459	Missense_Mutation	NA	L1393V	0.4
UCEC	chr3	47122042	Missense_Mutation	NA	N865S	0.25
UCEC	chr3	47122521	Silent	rs771398677	S705S	0.33
UCEC	chr3	47106083	Missense_Mutation	NA	D1585N	0.28
UCEC	chr3	47122268	Missense_Mutation	novel	D790Y	0.38
UCEC	chr3	47126662	Nonsense_Mutation	novel	E25*	0.25
UCEC	chr3	47046580	Silent	novel	Q2335Q	0.15
UCEC	chr3	47116641	Missense_Mutation	novel	R1523H	0.19
UCEC	chr3	47121168	Silent	novel	R1156R	0.2
UCEC	chr3	47123159	Missense_Mutation	rs778693117	R493W	0.16
UCEC	chr3	47037771	Silent	NA	T2415T	0.33
UCEC	chr3	47042679	Missense_Mutation	novel	N2374H	0.47
UCEC	chr3	47116748	Silent	NA	K1487K	0.42
UCEC	chr3	47122307	Nonsense_Mutation	NA	E777*	0.28
UCEC	chr3	47122253	Missense_Mutation	novel	C795R	0.36
UCEC	chr3	47121169	Missense_Mutation	rs752223546	R1156H	0.34
UCEC	chr3	47121582	Silent	rs192593730	A1018A	0.07
UCEC	chr3	47080876	Intron	rs772233306		0.33
UCEC	chr3	47122800	Silent	NA	A612A	0.4
UCEC	chr3	47057458	Missense_Mutation	NA	R2109Q	0.38
UCEC	chr3	47084303	Missense_Mutation	NA	R1826H	0.52
UCEC	chr3	47106043	Missense_Mutation	novel	R1598Q	0.49
UCEC	chr3	47120717	Missense_Mutation	novel	D1307N	0.35
UCEC	chr3	47123269	Missense_Mutation	rs777476264	R456Q	0.38
UCEC	chr3	47123570	Missense_Mutation	novel	A356T	0.37
UCEC	chr3	47080976	Intron	novel		0.27
UCEC	chr3	47103373	Silent	novel	S1630S	0.35
UCEC	chr3	47123005	Missense_Mutation	NA	S544L	0.26
UCEC	chr3	47123338	Missense_Mutation	rs764693453	R433H	0.32
UCS	chr3	47062337	Missense_Mutation	novel	R2040Q	0.32
UVM	chr3	47062338	Nonsense_Mutation	NA	R2040*	0.43

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.8056	0.02241
DLBC	DEL	0.1458	0.016959
GBM	DEL	0.0849	0.056565
LGG	DEL	0.0877	0.00089193
LUAD	DEL	0.3391	0.0021265
PAAD	DEL	0.1902	0.030662
SARC	DEL	0.2062	0.0034746
SKCM	DEL	0.1608	0.13887
TGCT	DEL	0.2	0.08422
THYM	DEL	0.0976	0.037527

Survival Analysis

Cancer	P-value	Q-value
THYM	0.026	Kaplan-Meier Survival Analysis
KIRC	0.00038	Kaplan-Meier Survival Analysis
SARC	0.012	Kaplan-Meier Survival Analysis
MESO	0.02	Kaplan-Meier Survival Analysis
ACC	0.016	Kaplan-Meier Survival Analysis
SKCM	0.0085	Kaplan-Meier Survival Analysis
KIRP	0.044	Kaplan-Meier Survival Analysis
READ	0.0064	Kaplan-Meier Survival Analysis
KICH	0.017	Kaplan-Meier Survival Analysis
GBM	0.039	Kaplan-Meier Survival Analysis
LIHC	0.015	Kaplan-Meier Survival Analysis
LGG	0.0007	Kaplan-Meier Survival Analysis
CHOL	0.033	Kaplan-Meier Survival Analysis
LUAD	0.015	Kaplan-Meier Survival Analysis
UVM	0.0033	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000181555 (Gene tree)
Gene ID: 29072
Gene Symbol: SETD2
Alias: HYPB|HIF-1|KIAA1732|FLJ23184|KMT3A
Full Name: SET domain containing 2, histone lysine methyltransferase
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 147,570 bases
Position: chr3:47,016,408-47,163,977
Accession: 18420
RBP type: non-canonical RBP
Summary: Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
28483910	RNA Binding by Histone Methyltransferases Set1 and Set2.	Mol Cell Biol	2017 Jun 29	Sayou C	doi: 10.1128/MCB.00165-17
30487242	Integrated Genomic and Proteomic Analyses Reveal Novel Mechanisms of the Methyltransferase SETD2 in Renal Cell Carcinoma Development.	Mol Cell Proteomics	2019 Mar	Li L	doi: 10.1074/mcp.RA118.000957
19711185	High-resolution protein structure determination starting with a global fold calculated from exact solutions to the RDC equations.	J Biomol NMR	2009 Nov	Zeng J	doi: 10.1007/s10858-009-9366-3
18923077	Histone H3 K36 methylation is mediated by a trans-histone methylation pathway involving an interaction between Set2 and histone H4.	Genes Dev	2008 Oct 15	Du HN	doi: 10.1101/gad.1700008.
28304334	KDM2 Family Members are Regulated by HIF-1 in Hypoxia.	Cells	2017 Mar 17	Batie M	doi: 10.3390/cells6010008.
28498454	Identification of SETD2-NF1 fusion gene in a pediatric spindle cell tumor with the chromosomal translocation t(3;17)(p21;q12).	Oncol Rep	2017 Jun	Panagopoulos I	doi: 10.3892/or.2017.5628

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000638947	SETD2-209	1984	-	ENSP00000491413	591 (aa)	-	A0A1W2PPX9
ENST00000409792	SETD2-202	8142	XM_011533632	ENSP00000386759	2564 (aa)	XP_011531934	Q9BYW2
ENST00000492397	SETD2-208	746	-	-	- (aa)	-	-
ENST00000484689	SETD2-207	561	-	-	- (aa)	-	-
ENST00000330022	SETD2-201	8172	-	ENSP00000332415	1365 (aa)	-	H7BXT4
ENST00000412450	SETD2-203	4231	-	ENSP00000416401	1340 (aa)	-	C9JG86
ENST00000479832	SETD2-206	794	-	-	- (aa)	-	-
ENST00000431180	SETD2-204	7555	-	ENSP00000388349	1290 (aa)	-	H7BZ93
ENST00000445387	SETD2-205	7075	-	ENSP00000411901	1675 (aa)	-	H7C3H4

Gene Model

Click here to download ENSG00000181555's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00310	Lysine degradation	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000181555	Child Development Disorders, Pervasive	3.5861800E-005	-
ENSG00000181555	Cholesterol, HDL	4E-9	24097068
ENSG00000181555	Bronchodilator Agents	3E-6	26634245
ENSG00000181555	Lung Volume Measurements	3E-6	26634245

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000181555	rs13063578	3	47046347	A	Monocyte count	27863252	[0.019-0.033] unit increase	0.02587866	EFO_0005091
ENSG00000181555	rs151074357	3	47034978	C	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.24	GO_0097366\|EFO_0004713
ENSG00000181555	rs2290547	3	47019693	A	HDL cholesterol	24097068	[NR] unit decrease	0.03	EFO_0004612
ENSG00000181555	rs17784127	3	47020210	T	Highest math class taken (MTAG)	30038396	[0.007-0.0136] unit increase	0.0103	EFO_0004875
ENSG00000181555	rs543811905	3	47029484	CA	Granulocyte percentage of myeloid white cells	27863252	[0.031-0.05] unit increase	0.04058472	EFO_0007997
ENSG00000181555	rs13063578	3	47046347	A	Lymphocyte counts	27863252	[0.048-0.062] unit increase	0.0547414	EFO_0004587
ENSG00000181555	rs13063578	3	47046347	A	Lymphocyte percentage of white cells	27863252	[0.024-0.039] unit increase	0.03160705	EFO_0007993
ENSG00000181555	rs13063578	3	47046347	A	White blood cell count (basophil)	27863252	[0.014-0.028] unit increase	0.02122998	EFO_0005090
ENSG00000181555	rs543811905	3	47029484	CA	Platelet distribution width	27863252	[0.036-0.055] unit increase	0.04532362	EFO_0007984
ENSG00000181555	rs13063578	3	47046347	A	White blood cell count	27863252	[0.026-0.04] unit increase	0.032872	EFO_0004308
ENSG00000181555	rs543811905	3	47029484	CA	Monocyte percentage of white cells	27863252	[0.021-0.04] unit decrease	0.0304442	EFO_0007989
ENSG00000181555	rs111675602	3	47118447	C	Macrophage inflammatory protein 1b levels	27989323	[0.2-0.31] SD units decrease	0.2548	EFO_0008219
ENSG00000181555	rs2290547	3	47019693	A	HDL cholesterol levels	28334899	[0.021-0.039] unit decrease (EA Beta values)	0.0297	EFO_0004612
ENSG00000181555	rs12631730	3	47088413	?	Reaction time	29844566	[0.0049-0.0118] unit increase	0.0083757	EFO_0008393
ENSG00000181555	rs114151323	3	47142565	?	White blood cell count	30595370			EFO_0004308
ENSG00000181555	rs4082155	3	47083895	A	Waist-to-hip ratio adjusted for BMI (additive genetic model)	30778226	[0.0079-0.0177] unit increase	0.0128	EFO_0007788
ENSG00000181555	rs4082155	3	47083895	A	Waist-to-hip ratio adjusted for BMI (additive genetic model)	30778226	[0.0089-0.0227] unit increase	0.0158	EFO_0007788

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000181555's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001525	angiogenesis	-	IEA	Process
GO:0001763	morphogenesis of a branching structure	-	IEA	Process
GO:0001843	neural tube closure	-	IEA	Process
GO:0005515	protein binding	17500595.19141475.21988832.28753426.	IPI	Function
GO:0005634	nucleus	-	ISS	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005694	chromosome	-	ISS	Component
GO:0006298	mismatch repair	23622243.	IMP	Process
GO:0006355	regulation of transcription, DNA-templated	-	IEA	Process
GO:0006368	transcription elongation from RNA polymerase II promoter	23325844.	IMP	Process
GO:0010569	regulation of double-strand break repair via homologous recombination	24843002.	IDA	Process
GO:0010793	regulation of mRNA export from nucleus	19141475.	IMP	Process
GO:0016279	protein-lysine N-methyltransferase activity	28753426.	IDA	Function
GO:0018023	peptidyl-lysine trimethylation	27518565.	IDA	Process
GO:0018024	histone-lysine N-methyltransferase activity	23043551.	IDA	Function
GO:0018024	histone-lysine N-methyltransferase activity	23622243.	IMP	Function
GO:0018024	histone-lysine N-methyltransferase activity	-	TAS	Function
GO:0018026	peptidyl-lysine monomethylation	28753426.	IDA	Process
GO:0030900	forebrain development	-	IEA	Process
GO:0032465	regulation of cytokinesis	27518565.	IDA	Process
GO:0032727	positive regulation of interferon-alpha production	28753426.	IDA	Process
GO:0034340	response to type I interferon	28753426.	IDA	Process
GO:0034728	nucleosome organization	23325844.	IMP	Process
GO:0035441	cell migration involved in vasculogenesis	-	IEA	Process
GO:0035987	endodermal cell differentiation	-	ISS	Process
GO:0043014	alpha-tubulin binding	27518565.	IDA	Function
GO:0046872	metal ion binding	-	IEA	Function
GO:0046975	histone methyltransferase activity (H3-K36 specific)	24843002.26002201.27474439.28753426.	IDA	Function
GO:0048332	mesoderm morphogenesis	-	IEA	Process
GO:0048701	embryonic cranial skeleton morphogenesis	-	IEA	Process
GO:0048863	stem cell differentiation	-	ISS	Process
GO:0048864	stem cell development	-	IEA	Process
GO:0051607	defense response to virus	28753426.	IDA	Process
GO:0060039	pericardium development	-	IEA	Process
GO:0060669	embryonic placenta morphogenesis	-	IEA	Process
GO:0060977	coronary vasculature morphogenesis	-	IEA	Process
GO:0097198	histone H3-K36 trimethylation	23043551.24843002.26002201.27474439.28753426.	IDA	Process
GO:0097198	histone H3-K36 trimethylation	19141475.23325844.23622243.	IMP	Process
GO:0097676	histone H3-K36 dimethylation	26002201.	IDA	Process
GO:1902850	microtubule cytoskeleton organization involved in mitosis	27518565.	IDA	Process
GO:1905634	regulation of protein localization to chromatin	24843002.	IDA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.