EuRBPDB

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Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr14	20510770	Nonsense_Mutation	NA	S100*	0.23
BLCA	chr14	20510657	Frame_Shift_Ins	novel	*Q63Rfs62**	0.04
BRCA	chr14	20510889	Missense_Mutation	novel	F140V	0.25	RnaseA
CESC	chr14	20510667	Missense_Mutation	NA	E66K	0.35
COAD	chr14	20510833	Missense_Mutation	NA	D121V	0.24
COAD	chr14	20511090	Missense_Mutation	novel	D207N	0.33	RnaseA
COAD	chr14	20510913	Missense_Mutation	novel	V148F	0.17	RnaseA
COAD	chr14	20510852	Missense_Mutation	NA	M127I	0.29
COAD	chr14	20510672	Silent	rs574467521	T67T	0.68
COAD	chr14	20510772	Missense_Mutation	NA	A101S	0.16
COAD	chr14	20510963	Frame_Shift_Del	novel	*K165Nfs11**	0.36	RnaseA
GBM	chr14	20510694	Missense_Mutation	novel	V75M	0.19
GBM	chr14	20510957	Silent	rs777764075	K162K	0.33
GBM	chr14	20510877	Missense_Mutation	novel	A136T	0.2
HNSC	chr14	20510637	Missense_Mutation	novel	T56S	0.44
HNSC	chr14	20510782	Frame_Shift_Del	novel	*Q104Pfs2**	0.2
LAML	chr14	20511026	Silent	novel	Q185Q	0.06
LIHC	chr14	20510956	Missense_Mutation	NA	K162M	0.14	RnaseA
LIHC	chr14	20511149	3'UTR	novel		0.4
LUAD	chr14	20510730	Missense_Mutation	novel	G87C	0.24
LUAD	chr14	20510731	Missense_Mutation	novel	G87V	0.24
LUAD	chr14	20510980	Frame_Shift_Del	novel	*R171Dfs5**	0.08	RnaseA
LUAD	chr14	20510482	Missense_Mutation	novel	N4T	0.1
LUAD	chr14	20510672	Silent	novel	T67T	0.07
LUAD	chr14	20510541	Missense_Mutation	novel	G24W	0.61
LUAD	chr14	20511034	Missense_Mutation	NA	P188H	0.21	RnaseA
LUAD	chr14	20510594	Silent	novel	L41L	0.11
LUAD	chr14	20510954	Silent	NA	L161L	0.22
LUAD	chr14	20510930	Silent	novel	N153N	0.24
LUAD	chr14	20510606	Missense_Mutation	NA	W45C	0.43
LUAD	chr14	20510925	Missense_Mutation	novel	C152G	0.1	RnaseA
LUSC	chr14	20510958	Missense_Mutation	novel	G163R	0.25	RnaseA
LUSC	chr14	20510712	Missense_Mutation	NA	P81T	0.13
LUSC	chr14	20510714	Silent	NA	P81P	0.13
LUSC	chr14	20510504	Missense_Mutation	rs772819067	M11I	0.15
LUSC	chr14	20510756	Silent	novel	K95K	0.3
LUSC	chr14	20510631	Missense_Mutation	novel	E54Q	0.28
LUSC	chr14	20510529	Missense_Mutation	NA	G20W	0.14
LUSC	chr14	20511115	Missense_Mutation	NA	G215V	0.53	RnaseA
OV	chr14	20511147	3'UTR	novel		0.14
OV	chr14	20510950	Missense_Mutation	novel	E160G	0.12	RnaseA
OV	chr14	20510951	Missense_Mutation	novel	E160D	0.11	RnaseA
SARC	chr14	20510891	Missense_Mutation	novel	F140L	0.3	RnaseA
SARC	chr14	20510817	Missense_Mutation	novel	D116N	0.24
SKCM	chr14	20510962	Missense_Mutation	NA	G164E	0.26	RnaseA
SKCM	chr14	20510856	Missense_Mutation	NA	E129K	0.38
SKCM	chr14	20510474	Translation_Start_Site	NA	M1?	0.26
SKCM	chr14	20510959	Missense_Mutation	rs370802392	G163E	0.29	RnaseA
SKCM	chr14	20510983	Missense_Mutation	rs375918997	R171Q	0.24	RnaseA
SKCM	chr14	20510646	Missense_Mutation	novel	G59R	0.45
SKCM	chr14	20510647	Missense_Mutation	novel	G59E	0.45
SKCM	chr14	20510474	Translation_Start_Site	NA	M1?	0.39
SKCM	chr14	20510726	Silent	NA	I85I	0.2
SKCM	chr14	20510962	Missense_Mutation	NA	G164E	0.25	RnaseA
SKCM	chr14	20510676	Missense_Mutation	rs201207144	V69M	0.26
SKCM	chr14	20510677	Missense_Mutation	novel	V69G	0.25
STAD	chr14	20510708	Silent	NA	G79G	0.13
STAD	chr14	20510717	Silent	NA	E82E	0.34
STAD	chr14	20511063	Missense_Mutation	NA	K198Q	0.12	RnaseA
STAD	chr14	20510616	Missense_Mutation	rs147896742	S49A	0.16
STAD	chr14	20510919	Missense_Mutation	NA	A150T	0.26	RnaseA
STAD	chr14	20510479	Missense_Mutation	rs776425443	L3P	0.07
UCEC	chr14	20510525	Silent	NA	G18G	0.46
UCEC	chr14	20510570	Silent	novel	V33V	0.29
UCEC	chr14	20510883	Missense_Mutation	NA	Y138H	0.32
UCEC	chr14	20511066	Missense_Mutation	NA	K199Q	0.41	RnaseA
UCEC	chr14	20510956	Frame_Shift_Ins	novel	*C166Mfs9**	0.25	RnaseA
UCEC	chr14	20510764	Missense_Mutation	novel	R98K	0.45
UCEC	chr14	20510760	Missense_Mutation	novel	L97I	0.44
UCEC	chr14	20510724	Missense_Mutation	NA	I85V	0.38
UCEC	chr14	20510930	Silent	novel	N153N	0.41
UCEC	chr14	20511083	Silent	NA	T204T	0.32
UCEC	chr14	20510498	Missense_Mutation	NA	F9L	0.27
UCEC	chr14	20510948	Silent	NA	C159C	0.29
UCEC	chr14	20511046	Missense_Mutation	NA	Y192C	0.41	RnaseA
UCEC	chr14	20510890	Missense_Mutation	novel	F140S	0.31	RnaseA
UCEC	chr14	20510616	Missense_Mutation	rs147896742	S49P	0.2
UCEC	chr14	20510736	Missense_Mutation	rs746879131	D89N	0.44
UCS	chr14	20511065	Missense_Mutation	novel	K198N	0.46	RnaseA

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1444	0.19769
CHOL	DEL	0.3611	0.00040262
HNSC	DEL	0.1054	0.0025503
KIRP	DEL	0.1632	0.085174
LUSC	DEL	0.2555	0.0082553
PAAD	DEL	0.087	0.11332
READ	DEL	0.3697	0.0043084

Survival Analysis

Cancer	P-value	Q-value
ACC	0.038	Kaplan-Meier Survival Analysis
BRCA	0.0098	Kaplan-Meier Survival Analysis
COAD	0.044	Kaplan-Meier Survival Analysis
PAAD	0.005	Kaplan-Meier Survival Analysis
PCPG	0.02	Kaplan-Meier Survival Analysis
KICH	0.0014	Kaplan-Meier Survival Analysis
LIHC	0.0093	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.025	Kaplan-Meier Survival Analysis
OV	0.012	Kaplan-Meier Survival Analysis

Description

RBDs

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000182545 (Gene tree)
Gene ID: 338879
Gene Symbol: RNASE10
Alias: RNASE9|RAH1
Full Name: ribonuclease A family member 10 (inactive)
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 5,633 bases
Position: chr14:20,505,537-20,511,169
Accession: 19275
RBP type: canonical RBP
Summary: (Ribonuclease A Family Member 10 (Inactive)) is a Protein Coding gene. Diseases associated with RNASE10 include Orchitis. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ribonuclease activity. An important paralog of this gene is RNASE6.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000333358	RnaseA	PF00074.20	1.3e-20	1	1
ENSP00000392996	RnaseA	PF00074.20	1.7e-20	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000328444	RNASE10-201	717	-	ENSP00000333358	216 (aa)	-	Q5GAN6
ENST00000430083	RNASE10-202	1172	-	ENSP00000392996	244 (aa)	-	Q5GAN6

Gene Model

Click here to download ENSG00000182545's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000182545's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000182545	RNASE10	100	68.981	ENSAMEG00000019710	RNASE10	100	68.981	Ailuropoda_melanoleuca
ENSG00000182545	RNASE10	99	65.888	ENSBTAG00000032869	RNASE10	100	65.888	Bos_taurus
ENSG00000182545	RNASE10	100	86.111	ENSCJAG00000009666	RNASE10	100	86.175	Callithrix_jacchus
ENSG00000182545	RNASE10	100	67.593	ENSCAFG00000005421	RNASE10	100	67.593	Canis_familiaris
ENSG00000182545	RNASE10	100	67.593	ENSCAFG00020014393	RNASE10	87	67.873	Canis_lupus_dingo
ENSG00000182545	RNASE10	98	65.566	ENSCHIG00000002322	RNASE10	99	64.953	Capra_hircus
ENSG00000182545	RNASE10	100	65.278	ENSCAPG00000017239	RNASE10	100	65.278	Cavia_aperea
ENSG00000182545	RNASE10	100	72.685	ENSCPOG00000034453	RNASE10	85	72.477	Cavia_porcellus
ENSG00000182545	RNASE10	100	71.296	ENSCLAG00000000661	RNASE10	100	71.296	Chinchilla_lanigera
ENSG00000182545	RNASE10	99	90.233	ENSCSAG00000000353	RNASE10	100	90.233	Chlorocebus_sabaeus
ENSG00000182545	RNASE10	100	68.519	ENSCHOG00000000564	RNASE10	100	68.519	Choloepus_hoffmanni
ENSG00000182545	RNASE10	95	59.709	ENSCGRG00001014976	Rnase10	96	59.709	Cricetulus_griseus_chok1gshd
ENSG00000182545	RNASE10	95	59.709	ENSCGRG00000009151	Rnase10	96	59.709	Cricetulus_griseus_crigri
ENSG00000182545	RNASE10	97	69.378	ENSDNOG00000042672	RNASE10	93	69.668	Dasypus_novemcinctus
ENSG00000182545	RNASE10	100	67.593	ENSDORG00000026247	Rnase10	100	67.593	Dipodomys_ordii
ENSG00000182545	RNASE10	99	65.899	ENSETEG00000015702	RNASE10	99	65.899	Echinops_telfairi
ENSG00000182545	RNASE10	98	73.585	ENSEASG00005017517	RNASE10	99	73.585	Equus_asinus_asinus
ENSG00000182545	RNASE10	98	74.057	ENSECAG00000001454	RNASE10	99	74.057	Equus_caballus
ENSG00000182545	RNASE10	100	66.667	ENSEEUG00000002380	RNASE10	100	66.667	Erinaceus_europaeus
ENSG00000182545	RNASE10	100	73.148	ENSFCAG00000006935	RNASE10	100	73.272	Felis_catus
ENSG00000182545	RNASE10	98	73.585	ENSFDAG00000003880	-	98	73.585	Fukomys_damarensis
ENSG00000182545	RNASE10	98	74.057	ENSFDAG00000018226	-	98	74.057	Fukomys_damarensis
ENSG00000182545	RNASE10	100	70.833	ENSHGLG00000020019	RNASE10	100	70.833	Heterocephalus_glaber_female
ENSG00000182545	RNASE10	100	71.296	ENSHGLG00100020231	RNASE10	100	71.296	Heterocephalus_glaber_male
ENSG00000182545	RNASE10	100	64.815	ENSSTOG00000012478	RNASE10	100	64.815	Ictidomys_tridecemlineatus
ENSG00000182545	RNASE10	85	66.667	ENSJJAG00000019054	Rnase10	92	65.775	Jaculus_jaculus
ENSG00000182545	RNASE10	96	71.635	ENSLAFG00000003746	RNASE10	87	72.487	Loxodonta_africana
ENSG00000182545	RNASE10	99	93.488	ENSMMUG00000019128	RNASE10	100	93.488	Macaca_mulatta
ENSG00000182545	RNASE10	95	60.870	ENSMAUG00000011002	Rnase10	84	61.244	Mesocricetus_auratus
ENSG00000182545	RNASE10	97	61.722	ENSMOCG00000010914	Rnase10	84	61.611	Microtus_ochrogaster
ENSG00000182545	RNASE10	89	65.741	MGP_CAROLIEiJ_G0019212	Rnase10	99	65.421	Mus_caroli
ENSG00000182545	RNASE10	89	66.204	ENSMUSG00000021872	Rnase10	99	65.888	Mus_musculus
ENSG00000182545	RNASE10	88	67.290	MGP_PahariEiJ_G0030235	Rnase10	99	66.981	Mus_pahari
ENSG00000182545	RNASE10	89	65.741	MGP_SPRETEiJ_G0020104	Rnase10	99	65.421	Mus_spretus
ENSG00000182545	RNASE10	100	69.907	ENSMPUG00000018388	RNASE10	100	69.907	Mustela_putorius_furo
ENSG00000182545	RNASE10	98	75.587	ENSMLUG00000014964	RNASE10	98	75.587	Myotis_lucifugus
ENSG00000182545	RNASE10	98	72.512	ENSNGAG00000005828	Rnase10	87	72.770	Nannospalax_galili
ENSG00000182545	RNASE10	98	61.792	ENSOPRG00000017084	RNASE10	98	61.792	Ochotona_princeps
ENSG00000182545	RNASE10	100	67.130	ENSODEG00000001824	RNASE10	98	66.972	Octodon_degus
ENSG00000182545	RNASE10	100	65.741	ENSOCUG00000005029	RNASE10	99	65.596	Oryctolagus_cuniculus
ENSG00000182545	RNASE10	100	74.074	ENSOGAG00000013058	RNASE10	100	74.074	Otolemur_garnettii
ENSG00000182545	RNASE10	98	64.623	ENSOARG00000019732	RNASE10	85	64.352	Ovis_aries
ENSG00000182545	RNASE10	100	71.759	ENSPPRG00000020158	RNASE10	100	71.889	Panthera_pardus
ENSG00000182545	RNASE10	100	72.685	ENSPTIG00000004211	RNASE10	100	72.811	Panthera_tigris_altaica
ENSG00000182545	RNASE10	86	66.351	ENSPEMG00000006846	Rnase10	84	66.351	Peromyscus_maniculatus_bairdii
ENSG00000182545	RNASE10	100	96.759	ENSPPYG00000005569	RNASE10	100	96.759	Pongo_abelii
ENSG00000182545	RNASE10	99	63.256	ENSPCAG00000000873	RNASE10	100	63.256	Procavia_capensis
ENSG00000182545	RNASE10	84	65.934	ENSRNOG00000010261	Rnase10	98	66.667	Rattus_norvegicus
ENSG00000182545	RNASE10	79	33.523	ENSSHAG00000003319	-	84	32.258	Sarcophilus_harrisii
ENSG00000182545	RNASE10	95	53.883	ENSSARG00000004246	RNASE10	94	54.187	Sorex_araneus
ENSG00000182545	RNASE10	99	66.512	ENSSSCG00000002134	RNASE10	99	66.512	Sus_scrofa
ENSG00000182545	RNASE10	99	69.444	ENSTTRG00000007870	RNASE10	99	69.444	Tursiops_truncatus
ENSG00000182545	RNASE10	99	66.822	ENSUAMG00000021833	RNASE10	99	66.822	Ursus_americanus
ENSG00000182545	RNASE10	97	68.095	ENSUMAG00000009190	RNASE10	99	68.095	Ursus_maritimus
ENSG00000182545	RNASE10	100	66.667	ENSVVUG00000009021	RNASE10	89	66.972	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003676	nucleic acid binding	-	IEA	Function
GO:0004540	ribonuclease activity	21873635.	IBA	Function
GO:0004540	ribonuclease activity	15676279.	IKR	Function
GO:0005576	extracellular region	-	IEA	Component
GO:0007338	single fertilization	-	IEA	Process
GO:0022409	positive regulation of cell-cell adhesion	-	ISS	Process
GO:0034113	heterotypic cell-cell adhesion	-	ISS	Process
GO:0080154	regulation of fertilization	-	ISS	Process
GO:0090501	RNA phosphodiester bond hydrolysis	-	IEA	Process
GO:1902093	positive regulation of flagellated sperm motility	-	ISS	Process

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.