EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
19764771Anxa2 plays a critical role in enhanced invasiveness of the multidrug resistant human breast cancer cells.J Proteome Res2009 NovZhang Fdoi: 10.1021/pr900461c.
25287627Serum annexin A2 levels in patients with colon cancer in comparison to healthy controls and in relation to tumor pathology.Med Sci Monit2014 Oct 3Gurluler Edoi: 10.12659/MSM.892319.
28476852Relationship Between Circulating Tumor Cells and Annexin A2 in Early Breast Cancer Patients.Anticancer Res2017 MayBystricky B-
29097873Expression of annexin II in gastric carcinoma and its role in gastric cancer metastasis.World J Gastroenterol2017 Oct 14Han Fdoi: 10.3748/wjg.v23.i38.7009.
26797420Long-term efficacy and downstream mechanism of anti-annexinA2 monoclonal antibody (anti-ANX A2 mAb) in a pre-clinical model of aggressive human breast cancer.Cancer Lett2016 Apr 1Sharma MCdoi: 10.1016/j.canlet.2016.01.013
20047591Annexin II promotes invasion and migration of human hepatocellular carcinoma cells in vitro via its interaction with HAb18G/CD147.Cancer Sci2010 FebZhao Pdoi: 10.1111/j.1349-7006.2009.01420.x
25344575ERG oncoprotein inhibits ANXA2 expression and function in prostate cancer.Mol Cancer Res2015 FebGriner NBdoi: 10.1158/1541-7786.MCR-14-0275-T
25795236Association of a characteristic membrane pattern of annexin A2 with high invasiveness and nodal status in colon adenocarcinoma.Transl Res2015 AugTristante Edoi: 10.1016/j.trsl.2015.02.006
20018898Annexin A2 is a molecular target for TM601, a peptide with tumor-targeting and anti-angiogenic effects.J Biol Chem2010 Feb 12Kesavan Kdoi: 10.1074/jbc.M109.066092
24968947Combined expression of S100A4 and Annexin A2 predicts disease progression and overall survival in patients with urothelial carcinoma.Urol Oncol2014 AugZhang Qdoi: 10.1016/j.urolonc.2014.02.009
24019232Identification of annexin II as a novel secretory biomarker for breast cancer.Proteomics2013 NovJeon YRdoi: 10.1002/pmic.201300127
26272794MIEN1, a novel interactor of Annexin A2, promotes tumor cell migration by enhancing AnxA2 cell surface expression.Mol Cancer2015 Aug 15Kpetemey Mdoi: 10.1186/s12943-015-0428-8.
29332450Identification and Comparison of Differentiation-Related Proteins in Hepatocellular Carcinoma Tissues by Proteomics.Technol Cancer Res Treat2017 DecZhao Sdoi: 10.1177/1533034617732426
25917452A novel Anxa2-interacting protein Ebp1 inhibits cancer proliferation and invasion by suppressing Anxa2 protein level.Mol Cell Endocrinol2015 Aug 15Zhang Fdoi: 10.1016/j.mce.2015.04.013
24591759Annexin A2: its molecular regulation and cellular expression in cancer development.Dis Markers2014Wang CYdoi: 10.1155/2014/308976
25034653Deregulated expression of annexin-A2 and galectin-3 is associated with metastasis in gastric cancer patients.Clin Exp Med2015 AugLeal MFdoi: 10.1007/s10238-014-0299-0
12629510Annexin II expression is reduced or lost in prostate cancer cells and its re-expression inhibits prostate cancer cell migration.Oncogene2003 Mar 13Liu JW-
18636554Annexin II/annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer.J Cell Biochem2008 Oct 1Shiozawa Ydoi: 10.1002/jcb.21835.
19724273S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility.Br J Cancer2009 Oct 6Nedjadi Tdoi: 10.1038/sj.bjc.6605289
28440436AnnexinA2 inhibition suppresses ovarian cancer progression via regulating β-catenin/EMT.Oncol Rep2017 JunLiu Ydoi: 10.3892/or.2017.5578
14613585Expression of biomarkers modulating prostate cancer angiogenesis: differential expression of annexin II in prostate carcinomas from India and USA.Mol Cancer2003 Oct 8Banerjee AG-
23792445Annexin A2 depletion delays EGFR endocytic trafficking via cofilin activation and enhances EGFR signaling and metastasis formation.Oncogene2014 May 15de Graauw Mdoi: 10.1038/onc.2013.219
23494179Clinical significance of annexin II expression in human non-small cell lung cancer.Tumour Biol2013 JunJia JWdoi: 10.1007/s13277-013-0715-1
22681645Upregulated expression of annexin II is a prognostic marker for patients with gastric cancer.World J Surg Oncol2012 Jun 8Zhang Qdoi: 10.1186/1477-7819-10-103.
25362534Human epididymis protein 4 in association with Annexin II promotes invasion and metastasis of ovarian cancer cells.Mol Cancer2014 Nov 1Zhuang Hdoi: 10.1186/1476-4598-13-243.
18924133Annexin A2 positively contributes to the malignant phenotype and secretion of IL-6 in DU145 prostate cancer cells.Int J Cancer2009 Jan 1Inokuchi Jdoi: 10.1002/ijc.23928.
27468721Identification of aldolase A as a potential diagnostic biomarker for colorectal cancer based on proteomic analysis using formalin-fixed paraffin-embedded tissue.Tumour Biol2016 OctYamamoto T-
24239898P-glycoprotein associates with Anxa2 and promotes invasion in multidrug resistant breast cancer cells.Biochem Pharmacol2014 Jan 15Zhang Fdoi: 10.1016/j.bcp.2013.11.003
15574370S100A10, annexin A2, and annexin a2 heterotetramer as candidate plasminogen receptors.Front Biosci2005 Jan 1Kwon M-
25150310Annexin A2 is implicated in multi-drug-resistance in gastric cancer through p38MAPK and AKT pathway.Neoplasma2014Zhang ZDdoi: 10.4149/neo_2014_078.
25661364Circulating annexin A2 as a biomarker in gastric cancer patients: correlation with clinical variables.Biomed Pharmacother2015 FebTas Fdoi: 10.1016/j.biopha.2014.12.005
25816213Knockdown of ubiquitin protein ligase E3A affects proliferation and invasion, and induces apoptosis of breast cancer cells through regulation of annexin A2.Mol Med Rep2015 JulZhou Xdoi: 10.3892/mmr.2015.3549
16643892Angiogenesis-associated protein annexin II in breast cancer: selective expression in invasive breast cancer and contribution to tumor invasion and progression.Exp Mol Pathol2006 OctSharma MR-
17441315Rna interference of annexin II gene in PC3 cells by using small interference RNA synthesized with in vitro transcription.Chin Med Sci J2007 MarYuan YW-
26307676Anxa2 binds to STAT3 and promotes epithelial to mesenchymal transition in breast cancer cells.Oncotarget2015 Oct 13Wang Tdoi: 10.18632/oncotarget.5199.
18712570Annexin II overexpression predicts rapid recurrence after surgery in pancreatic cancer patients undergoing gemcitabine-adjuvant chemotherapy.Ann Surg Oncol2008 NovTakano Sdoi: 10.1245/s10434-008-0061-5
26253946RNAi-mediated silencing of Anxa2 inhibits breast cancer cell proliferation by downregulating cyclin D1 in STAT3-dependent pathway.Breast Cancer Res Treat2015 SepZhang Fdoi: 10.1007/s10549-015-3529-6
15944914Localization of annexins I, II, IV and VII in whole prostate sections from radical prostatectomy patients.Histol Histopathol2005 JulLehnigk Udoi: 10.14670/HH-20.673.
20079732Breast cancer cell surface annexin II induces cell migration and neoangiogenesis via tPA dependent plasmin generation.Exp Mol Pathol2010 AprSharma Mdoi: 10.1016/j.yexmp.2010.01.001
25547062Annexin A2 plays a critical role in epithelial ovarian cancer.Arch Gynecol Obstet2015 JulDeng Ydoi: 10.1007/s00404-014-3598-5
25519022Evaluation of Annexin A2 as a novel diagnostic serum biomarker for lung cancer.Cancer Biomark2015Yang Jdoi: 10.3233/CBM-140455.
27667176Integrative Modeling Reveals Annexin A2-mediated Epigenetic Control of Mesenchymal Glioblastoma.EBioMedicine2016 OctKling Tdoi: 10.1016/j.ebiom.2016.08.050
24806074S100A11 is required for efficient plasma membrane repair and survival of invasive cancer cells.Nat Commun2014 May 8Jaiswal JKdoi: 10.1038/ncomms4795.
22044461Antibody-directed neutralization of annexin II (ANX II) inhibits neoangiogenesis and human breast tumor growth in a xenograft model.Exp Mol Pathol2012 FebSharma Mdoi: 10.1016/j.yexmp.2011.10.003
22917188Overexpression of annexin A2 is associated with abnormal ubiquitination in breast cancer.Genomics Proteomics Bioinformatics2012 JunDeng Sdoi: 10.1016/j.gpb.2011.12.001
26925708Annexin A2 and S100A10 are independent predictors of serous ovarian cancer outcome.Transl Res2016 MayLokman NAdoi: 10.1016/j.trsl.2016.02.002
27496793Annexin A2 and its downstream IL-6 and HB-EGF as secretory biomarkers in the differential diagnosis of Her-2 negative breast cancer.Ann Clin Biochem2017 JulShetty Pdoi: 10.1177/0004563216665867
27760843Exosomal Annexin II Promotes Angiogenesis and Breast Cancer Metastasis.Mol Cancer Res2017 JanMaji Sdoi: 10.1158/1541-7786.MCR-16-0163
29187477Proteins Annexin A2 and PSA in Prostate Cancer Biopsies Do Not Predict Biochemical Failure.Anticancer Res2017 DecLamb DS-
27008711Characterization of cervical cancer stem cell-like cells: phenotyping, stemness, and human papilloma virus co-receptor expression.Oncotarget2016 May 31Ortiz-S??nchez Edoi: 10.18632/oncotarget.8218.
28609840miR-101 alleviates chemoresistance of gastric cancer cells by targeting ANXA2.Biomed Pharmacother2017 AugBao Jdoi: 10.1016/j.biopha.2017.06.011
28867585Protein phosphorylation and its role in the regulation of Annexin A2 function.Biochim Biophys Acta Gen Subj2017 NovGrindheim AKdoi: 10.1016/j.bbagen.2017.08.024
28470457Tyr23 phosphorylation of Anxa2 enhances STAT3 activation and promotes proliferation and invasion of breast cancer cells.Breast Cancer Res Treat2017 JulYuan Jdoi: 10.1007/s10549-017-4271-z
28886730Annexin A2 contributes to cisplatin resistance by activation of JNK-p53 pathway in non-small cell lung cancer cells.J Exp Clin Cancer Res2017 Sep 8Feng Xdoi: 10.1186/s13046-017-0594-1.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1560349123Missense_MutationNAR304S0.19
BLCAchr1560355937SilentnovelL170L0.18
CESCchr1560355992Missense_MutationnovelK152R0.3
CESCchr1560382435Missense_MutationNAT19A0.2
CESCchr15603473973'UTRnovel0.56
CESCchr1560355987Missense_MutationnovelD154N0.29
COADchr1560364481Missense_MutationNAS64I0.3
COADchr1560352401Missense_Mutationrs374077954V222M0.33
COADchr1560364452Missense_Mutationrs774410888A74T0.39
COADchr1560386060Missense_MutationNAE6K0.15
ESCAchr1560352426Missense_MutationnovelW213C0.17
GBMchr1560355987Missense_MutationnovelD154N0.43
GBMchr1560349176Missense_MutationnovelV287F0.07
KIRCchr1560349125SilentNAR304R0.43
KIRPchr1560355754Intronnovel0.5
LAMLchr1560351795Missense_MutationnovelS236N0.09
LGGchr1560351818Splice_RegionnovelV228V0.07
LIHCchr1560386047Missense_MutationnovelK10M0.46
LUADchr1560349189SilentNAG282G0.26
LUADchr1560355830Intronnovel0.25
LUADchr1560360964Frame_Shift_Delrs752359543S112Lfs*30.48
LUADchr1560357190Missense_MutationNAR135I0.08
LUSCchr1560351213Missense_Mutationrs564741326R273W0.54
LUSCchr1560355954Missense_MutationnovelG165C0.4
OVchr1560357227Missense_MutationNAT123P0.49
OVchr1560360947SilentNAS117S0.33
OVchr15603476273'UTRnovel0.21
OVchr1560355578Intronnovel0.15
PAADchr1560355768Intronnovel0.1
PRADchr1560364521Missense_MutationNAV51M0.1
PRADchr1560349131Nonsense_MutationnovelK302*0.09
READchr1560347686Missense_MutationnovelD322H0.26
READchr1560355939Missense_MutationnovelL170M0.07
READchr15603476243'UTRnovel0.22
SKCMchr1560360947SilentNAS117S0.12
SKCMchr1560354154Splice_RegionnovelR196R0.67
SKCMchr1560354155Missense_Mutationrs771090624R196Q0.67
SKCMchr1560364453Silentrs140871735F73F0.36
SKCMchr1560360948Missense_MutationNAS117F0.16
SKCMchr1560357225SilentnovelT123T0.15
STADchr1560349186Silentrs769044999T283T0.44
STADchr1560349082Missense_MutationNAY318F0.13
STADchr1560364436Missense_MutationnovelT79I0.36
STADchr1560349184Missense_MutationnovelR284Q0.44
STADchr1560382350Missense_MutationNAK47T0.33
STADchr1560349158Missense_MutationNAV293I0.15
STADchr1560364428Frame_Shift_InsnovelE82Kfs*300.35
UCECchr1560355965Missense_Mutationrs138727673S161L0.36
UCECchr1560357221Missense_MutationnovelE125K0.18
UCECchr1560351783Missense_MutationnovelM240T0.04
UCECchr1560349162SilentNAI291I0.44
UCECchr1560360958Missense_MutationNAL114I0.35
UCECchr1560355898Intronnovel0.19
UCECchr1560352464Missense_Mutationrs767606956A201T0.64
UCECchr1560364452Missense_Mutationrs774410888A74T0.23
UCECchr1560364437Missense_MutationNAT79A0.13
UCECchr1560349196Missense_MutationnovelG280D0.32
UCECchr1560382437Missense_MutationnovelS18F0.26
UCECchr15603474713'UTRnovel0.31
UCECchr1560355863Intronnovel0.45
UCECchr1560349125SilentNAR304R0.42
UCECchr15603475933'UTRrs3696333820.44
UCECchr1560355750Intronnovel0.31
UCECchr1560351225Missense_Mutationrs1803909Y269H0.49
UCECchr1560397886Intronnovel0.75
UCECchr1560355965Missense_Mutationrs138727673S161L0.36
UCECchr1560349104Missense_MutationnovelY311H0.18
UCECchr1560357222Silentrs748528078D124D0.4
UCECchr1560360968Silentrs559081202D110D0.23
UCECchr15603475493'UTRnovel0.43
UCECchr1560354158Missense_MutationNAA195D0.11
UCECchr1560364484Missense_Mutationrs763951173R63H0.36
UVMchr1560355986Missense_MutationnovelD154V0.51

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.20.079424
KICHAMP0.27270.21756
KIRPDEL0.09720.2062
LGGAMP0.01560.19963
PAADAMP0.04890.20695
PAADDEL0.10870.13216
READDEL0.43640.025797

Survival Analysis
CancerP-value Q-value
KIRC0.00011

Kaplan-Meier Survival Analysis

MESO0.0001

Kaplan-Meier Survival Analysis

HNSC0.0027

Kaplan-Meier Survival Analysis

KIRP0.023

Kaplan-Meier Survival Analysis

PAAD0.00012

Kaplan-Meier Survival Analysis

BLCA0.00012

Kaplan-Meier Survival Analysis

CESC0.0059

Kaplan-Meier Survival Analysis

LAML0.049

Kaplan-Meier Survival Analysis

UCEC0.0013

Kaplan-Meier Survival Analysis

GBM0.011

Kaplan-Meier Survival Analysis

LIHC0.00012

Kaplan-Meier Survival Analysis

DLBC0.036

Kaplan-Meier Survival Analysis

LUAD0.0019

Kaplan-Meier Survival Analysis

UVM0.00011

Kaplan-Meier Survival Analysis

OV0.0052

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000182718 (Gene tree)
Gene ID
302
Gene Symbol
ANXA2
Alias
LIP2|ANX2|ANX2L4|CAL1H|LPC2D
Full Name
annexin A2
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
55,750 bases
Position
chr15:60,347,134-60,402,883
Accession
537
RBP type
non-canonical RBP
Summary
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
17068759Identification and analysis of altered alpha1,6-fucosylated glycoproteins associated with hepatocellular carcinoma metastasis.Proteomics2006 NovDai Z-
17330940Altered chaperone and protein turnover regulators expression in cultured skin fibroblasts from type 1 diabetes mellitus with nephropathy.J Proteome Res2007 MarTessari P-
23575152Proteomic profiles of the embryonic chorioamnion and uterine caruncles in buffaloes (Bubalus bubalis) with normal and retarded embryonic development.Biol Reprod2013 May 16Balestrieri MLdoi: 10.1095/biolreprod.113.108696
23084922Short-range exosomal transfer of viral RNA from infected cells to plasmacytoid dendritic cells triggers innate immunity.Cell Host Microbe2012 Oct 18Dreux Mdoi: 10.1016/j.chom.2012.08.010.
21918681Annexin A2 binds RNA and reduces the frameshifting efficiency of infectious bronchitis virus.PLoS One2011Kwak Hdoi: 10.1371/journal.pone.0024067
25806802Low expression of lncRNA-GAS5 is implicated in human primary varicose great saphenous veins.PLoS One2015 Mar 25Li Ldoi: 10.1371/journal.pone.0120550
289792073-Mercaptopyruvate Sulfurtransferase, Not Cystathionine β-Synthase Nor Cystathionine γ-Lyase, Mediates Hypoxia-Induced Migration of Vascular Endothelial Cells.Front Pharmacol2017 Sep 20Tao Bdoi: 10.3389/fphar.2017.00657
29228983Characterization of interactions between hepatitis C virus NS5B polymerase, annexin A2 and RNA - effects on NS5B catalysis and allosteric inhibition.Virol J2017 Dec 11Solbak SMOdoi: 10.1186/s12985-017-0904-4.
15654879Annexin A2 binds to the localization signal in the 3' untranslated region of c-myc mRNA.FEBS J2005 JanMickleburgh I-
14672933Annexin A2 is a novel RNA-binding protein.J Biol Chem2004 Mar 5Filipenko NR-
17395201The mRNA-binding site of annexin A2 resides in helices C-D of its domain IV.J Mol Biol2007 May 18Aukrust I-
17350708Characterization of the RNA-binding regions in protein p36 of Heliothis armigera cypovirus 14.Virus Res2007 MayChen W-
21995826A cis-acting region in the N-methyl-d-aspartate R1 3'-untranslated region interacts with the novel RNA-binding proteins beta subunit of alpha glucosidase II and annexin A2--effect of chronic ethanol exposure in vivo.Eur J Neurosci2011 OctAnji Adoi: 10.1111/j.1460-9568.2011.07857.x
30568638Annexin A2 in Virus Infection.Front Microbiol2018 Dec 5Taylor JRdoi: 10.3389/fmicb.2018.02954
204927An RNA transcribed from DNA at the origin of phage fd single strand to replicative form conversion.Proc Natl Acad Sci U S A1978 FebGeider K-
10679243Identification of casein kinase I substrates by in vitro expression cloning screening.Biochem Biophys Res Commun2000 Feb 16Gao ZH-
6141940Functional aspects of Escherichia coli rep helicase in unwinding and replication of DNA.Eur J Biochem1984 Jan 16Baumel I-
7836383Murine transcription factor alpha A-crystallin binding protein I. Complete sequence, gene structure, expression, and functional inhibition via antisense RNA.J Biol Chem1995 Jan 20Brady JP-
10839987Annexin II is associated with mRNAs which may constitute a distinct subpopulation.Biochem J2000 Jun 15Vedeler A-
16984921Legionella pneumophila induces IFNbeta in lung epithelial cells via IPS-1 and IRF3, which also control bacterial replication.J Biol Chem2006 Nov 24Opitz B-
22708494Multiple roles of annexin A2 in post-transcriptional regulation of gene expression.Curr Protein Pept Sci2012 JunVedeler A-
25139904Annexin A2 mediates Mycoplasma pneumoniae community-acquired respiratory distress syndrome toxin binding to eukaryotic cells.MBio2014 Aug 19Somarajan SRdoi: 10.1128/mBio.01497-14.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000451270ANXA2-2041435XM_017022093ENSP00000387545339 (aa)XP_016877582P07355
ENST00000559818ANXA2-226878-ENSP00000453859256 (aa)-H0YN42
ENST00000558985ANXA2-214780-ENSP00000453039142 (aa)-H0YL33
ENST00000558986ANXA2-215560-ENSP00000453739133 (aa)-H0YMT9
ENST00000560389ANXA2-231594-ENSP00000453579176 (aa)-H0YKS4
ENST00000332680ANXA2-2011444-ENSP00000346032357 (aa)-P07355
ENST00000559467ANXA2-221755-ENSP00000453000119 (aa)-H0YKZ7
ENST00000558558ANXA2-213513-ENSP00000452981134 (aa)-H0YKX9
ENST00000560165ANXA2-229718-ENSP00000452921176 (aa)-H0YKS4
ENST00000396024ANXA2-2021676-ENSP00000379342339 (aa)-P07355
ENST00000560495ANXA2-234567--- (aa)--
ENST00000561445ANXA2-238514--- (aa)--
ENST00000561022ANXA2-237834-ENSP0000045287669 (aa)-H0YKN4
ENST00000557937ANXA2-208694--- (aa)--
ENST00000560468ANXA2-233663-ENSP00000452858110 (aa)-H0YKL9
ENST00000559780ANXA2-225802-ENSP00000453770146 (aa)-H0YMW4
ENST00000558998ANXA2-216543-ENSP0000045392579 (aa)-H0YNA0
ENST00000560014ANXA2-2282339-ENSP00000453754230 (aa)-H0YMU9
ENST00000558169ANXA2-211557-ENSP0000045394547 (aa)-H0YNB8
ENST00000560546ANXA2-235574--- (aa)--
ENST00000560466ANXA2-232665-ENSP00000453841139 (aa)-H0YN28
ENST00000504475ANXA2-2053528--- (aa)--
ENST00000560936ANXA2-236908--- (aa)--
ENST00000559725ANXA2-224561-ENSP0000045317445 (aa)-H0YLE2
ENST00000559647ANXA2-223484--- (aa)--
ENST00000559176ANXA2-218744-ENSP00000453464248 (aa)-H0YM50
ENST00000559559ANXA2-2221076--- (aa)--
ENST00000558503ANXA2-212828-ENSP00000453356132 (aa)-H0YLV6
ENST00000421017ANXA2-2031444XM_017022090ENSP00000411352339 (aa)XP_016877579P07355
ENST00000559350ANXA2-219669-ENSP00000453663149 (aa)-H0YMM1
ENST00000557986ANXA2-209733-ENSP000004537424 (aa)-UPI00022F87BE
ENST00000559370ANXA2-220521-ENSP0000045356665 (aa)-H0YMD9
ENST00000559113ANXA2-217564-ENSP0000045386959 (aa)-H0YN52
ENST00000558132ANXA2-210580-ENSP00000454096175 (aa)-H0YNP5
ENST00000560367ANXA2-230777-ENSP00000453556227 (aa)-H0YMD0
ENST00000557904ANXA2-206369-ENSP0000045295881 (aa)-H0YKV8
ENST00000559956ANXA2-227558-ENSP00000453694119 (aa)-H0YKZ7
ENST00000557906ANXA2-207812-ENSP00000452895176 (aa)-H0YKS4
Gene Model
Click here to download ENSG00000182718's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG000001827183-hydroxy-1-methylpropylmercapturic acid3E-626053186
ENSG00000182718Smoking3E-626053186
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000182718rs169425561560395052?3-hydroxy-1-methylpropylmercapturic acid levels in smokers26053186[NR] unit increase1.1184EFO_0004318|EFO_0007015
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000182718's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000182718ANXA2100100.000ENSMUSG00000032231Anxa210099.130Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001525angiogenesis21873635.IBAProcess
GO:0001525angiogenesis11866539.IEPProcess
GO:0001726ruffle-IEAComponent
GO:0001765membrane raft assembly21873635.IBAProcess
GO:0001765membrane raft assembly23861394.IMPProcess
GO:0001786phosphatidylserine binding21873635.IBAFunction
GO:0001921positive regulation of receptor recycling21873635.IBAProcess
GO:0001921positive regulation of receptor recycling22848640.IDAProcess
GO:0001934positive regulation of protein phosphorylation21873635.IBAProcess
GO:0002020protease binding21873635.IBAFunction
GO:0002020protease binding22848640.IPIFunction
GO:0003417growth plate cartilage development21873635.IBAProcess
GO:0003723RNA binding22658674.HDAFunction
GO:0005262calcium channel activity21873635.IBAFunction
GO:0005509calcium ion binding-IEAFunction
GO:0005515protein binding21873635.IBAFunction
GO:0005515protein binding14522961.18799458.19724273.20706999.21044950.21645192.21886777.22301157.24457100.25136068.25139904.26812398.26941067.30021884.IPIFunction
GO:0005544calcium-dependent phospholipid binding21873635.IBAFunction
GO:0005544calcium-dependent phospholipid binding2138016.IDAFunction
GO:0005546phosphatidylinositol-4,5-bisphosphate binding21873635.IBAFunction
GO:0005546phosphatidylinositol-4,5-bisphosphate binding23861394.IMPFunction
GO:0005576extracellular region27068509.HDAComponent
GO:0005576extracellular region-TASComponent
GO:0005604basement membrane-IEAComponent
GO:0005615extracellular space22664934.HDAComponent
GO:0005615extracellular space21873635.IBAComponent
GO:0005634nucleus21630459.HDAComponent
GO:0005634nucleus21873635.IBAComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005737cytoplasm21645192.25139904.26812398.IDAComponent
GO:0005765lysosomal membrane23360953.IDAComponent
GO:0005768endosome18767904.21645192.IDAComponent
GO:0005769early endosome-IEAComponent
GO:0005811lipid droplet14741744.IDAComponent
GO:0005829cytosol-IEAComponent
GO:0005886plasma membrane21873635.IBAComponent
GO:0005886plasma membrane18799458.IDAComponent
GO:0005913cell-cell adherens junction25468996.HDAComponent
GO:0005938cell cortex-IEAComponent
GO:0006900vesicle budding from membrane21873635.IBAProcess
GO:0006900vesicle budding from membrane23861394.IMPProcess
GO:0007589body fluid secretion-IEAProcess
GO:0008092cytoskeletal protein binding-IEAFunction
GO:0009986cell surface10809787.25139904.IDAComponent
GO:0010755regulation of plasminogen activation21873635.IBAProcess
GO:0016020membrane19946888.HDAComponent
GO:0016323basolateral plasma membrane-ISSComponent
GO:0017137Rab GTPase binding21873635.IBAFunction
GO:0019834phospholipase A2 inhibitor activity21873635.IBAFunction
GO:0019834phospholipase A2 inhibitor activity3013422.IDAFunction
GO:0019897extrinsic component of plasma membrane-IEAComponent
GO:0030199collagen fibril organization21873635.IBAProcess
GO:0030496midbody15166316.IDAComponent
GO:0031214biomineral tissue development21873635.IBAProcess
GO:0031340positive regulation of vesicle fusion21873635.IBAProcess
GO:0031340positive regulation of vesicle fusion2138016.IDAProcess
GO:0031902late endosome membrane23360953.IDAComponent
GO:0031982vesicle19190083.HDAComponent
GO:0031982vesicle21873635.IBAComponent
GO:0032332positive regulation of chondrocyte differentiation21873635.IBAProcess
GO:0032804negative regulation of low-density lipoprotein particle receptor catabolic process21873635.IBAProcess
GO:0032804negative regulation of low-density lipoprotein particle receptor catabolic process22848640.IDAProcess
GO:0035578azurophil granule lumen-TASComponent
GO:0035722interleukin-12-mediated signaling pathway-TASProcess
GO:0035749myelin sheath adaxonal region-IEAComponent
GO:0036035osteoclast development21873635.IBAProcess
GO:0036035osteoclast development7961821.IDAProcess
GO:0042383sarcolemma-IEAComponent
GO:0042470melanosome-IEAComponent
GO:0042730fibrinolysis21873635.IBAProcess
GO:0042802identical protein binding21873635.IBAFunction
GO:0042802identical protein binding18799458.26812398.IPIFunction
GO:0043086negative regulation of catalytic activity-IEAProcess
GO:0043220Schmidt-Lanterman incisure-IEAComponent
GO:0043312neutrophil degranulation-TASProcess
GO:0044090positive regulation of vacuole organization21873635.IBAProcess
GO:0044090positive regulation of vacuole organization25139904.IMPProcess
GO:0044147negative regulation of development of symbiont involved in interaction with host21873635.IBAProcess
GO:0044147negative regulation of development of symbiont involved in interaction with host26812398.IMPProcess
GO:0044354macropinosome-IEAComponent
GO:0044548S100 protein binding21873635.IBAFunction
GO:0044548S100 protein binding14699089.23091277.IPIFunction
GO:0044730bone sialoprotein binding21873635.IBAFunction
GO:0044794positive regulation by host of viral process21873635.IBAProcess
GO:0045121membrane raft14699089.IDAComponent
GO:0046790virion binding21873635.IBAFunction
GO:0048146positive regulation of fibroblast proliferation21873635.IBAProcess
GO:0048306calcium-dependent protein binding15226301.IPIFunction
GO:0048471perinuclear region of cytoplasm-IEAComponent
GO:0051290protein heterotetramerization21873635.IBAProcess
GO:0051290protein heterotetramerization23091277.23861394.IDAProcess
GO:0051480regulation of cytosolic calcium ion concentration-IEAProcess
GO:0051928positive regulation of calcium ion transport21873635.IBAProcess
GO:0052362catabolism by host of symbiont protein21873635.IBAProcess
GO:0052362catabolism by host of symbiont protein26812398.IMPProcess
GO:0052405negative regulation by host of symbiont molecular function21873635.IBAProcess
GO:0052405negative regulation by host of symbiont molecular function26812398.IMPProcess
GO:0060956endocardial cell differentiation21873635.IBAProcess
GO:0062023collagen-containing extracellular matrix25037231.27559042.28675934.HDAComponent
GO:0062023collagen-containing extracellular matrix28327460.HDAComponent
GO:0062023collagen-containing extracellular matrix22261194.ISSComponent
GO:0070062extracellular exosome19056867.19199708.20458337.21362503.23533145.HDAComponent
GO:0070062extracellular exosome22057634.IDAComponent
GO:0070588calcium ion transmembrane transport-IEAProcess
GO:0072659protein localization to plasma membrane21873635.IBAProcess
GO:0097066response to thyroid hormone-IEAProcess
GO:0098609cell-cell adhesion-IEAProcess
GO:0098641cadherin binding involved in cell-cell adhesion25468996.HDAFunction
GO:0098772molecular function regulator22848640.IDAFunction
GO:0099511voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels21873635.IBAFunction
GO:1903902positive regulation of viral life cycle21873635.IBAProcess
GO:1905581positive regulation of low-density lipoprotein particle clearance21873635.IBAProcess
GO:1905581positive regulation of low-density lipoprotein particle clearance22848640.IDAProcess
GO:1905597positive regulation of low-density lipoprotein particle receptor binding21873635.IBAProcess
GO:1905597positive regulation of low-density lipoprotein particle receptor binding22848640.IDAProcess
GO:1905599positive regulation of low-density lipoprotein receptor activity21873635.IBAProcess
GO:1905599positive regulation of low-density lipoprotein receptor activity22848640.IMPProcess
GO:1905602positive regulation of receptor-mediated endocytosis involved in cholesterol transport21873635.IBAProcess
GO:1905602positive regulation of receptor-mediated endocytosis involved in cholesterol transport22848640.IDAProcess
GO:1990667PCSK9-AnxA2 complex22848640.IDAComponent
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