EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
28347232Expression of RNA-binding motif 10 is associated with advanced tumor stage and malignant behaviors of lung adenocarcinoma cancer cells.Tumour Biol2017 MarGuan Gdoi: 10.1177/1010428317691740.
26853560Tumor suppressor properties of the splicing regulatory factor RBM10.RNA Biol2016Hern??ndez Jdoi: 10.1080/15476286.2016.1144004.
28662214RBM10 promotes transformation-associated processes in small cell lung cancer and is directly regulated by RBM5.PLoS One2017 Jun 29Loiselle JJdoi: 10.1371/journal.pone.0180258
28634282Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of MED12 and RBM10 as Novel Thyroid Cancer Genes Associated with Tumor Virulence.Clin Cancer Res2017 Oct 1Ibrahimpasic Tdoi: 10.1158/1078-0432.CCR-17-1183
30403180Overexpression of RBM10 induces osteosarcoma cell apoptosis and inhibits cell proliferation and migration.Med Sci (Paris)2018 OctHan LPdoi: 10.1051/medsci/201834f114
18820371The small variant of the apoptosis-associated X-chromosome RBM10 gene is co-expressed with caspase-3 in breast cancer.Cancer Genomics Proteomics2008 May-AugMart??n-Garabato E-
16552754Positive correlation between the expression of X-chromosome RBM genes (RBMX, RBM3, RBM10) and the proapoptotic Bax gene in human breast cancer.J Cell Biochem2006 Apr 15Mart??nez-Arribas F-

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchrX47173131Missense_MutationnovelR146S0.17
ACCchrX47180484Missense_MutationnovelA409V0.2
BLCAchrX47182181Frame_Shift_InsnovelQ603Pfs*250.54
BLCAchrX47180005Missense_MutationNAR343C0.33
BLCAchrX47185601Missense_MutationNAR776W1
BLCAchrX47185103Nonsense_MutationNAE667*0.97
BLCAchrX47171118SilentnovelR98R0.4
BLCAchrX47179423Nonsense_MutationnovelQ277*0.38
BLCAchrX47181970SilentNAT571T0.6
BLCAchrX47186134Nonsense_MutationNAK834*0.51
BLCAchrX47169425Nonsense_MutationnovelS43*0.96
BLCAchrX47185617Missense_MutationNAS781L0.45
BLCAchrX47176562Frame_Shift_InsnovelN214Kfs*20.41
BLCAchrX47180416Splice_Regionnovel0.91
BLCAchrX47182177Nonsense_MutationNAQ601*0.59
BLCAchrX47182171Missense_MutationNAN599H0.11
BLCAchrX47185132SilentNAI676I0.36
BLCAchrX47185011Splice_SitenovelX651_splice0.44
BLCAchrX47186092Missense_MutationNAE820K0.44
BLCAchrX47179457Nonsense_MutationNAS288*0.33
BLCAchrX47186142SilentnovelR836R0.12
BLCAchrX47185625Missense_MutationNAH784D0.63
BLCAchrX47179127Nonsense_MutationNAR230*0.36
BLCAchrX47185607Nonsense_MutationnovelQ778*0.8
BLCAchrX471474425'UTRnovel0.52
BLCAchrX47181333Frame_Shift_DelnovelH457Mfs*280.86
BLCAchrX47171250Missense_MutationnovelE142K0.83
BLCAchrX47181835Frame_Shift_DelnovelP555Cfs*200.57
BRCAchrX47182246Missense_MutationNAD624N0.15
BRCAchrX47181263Missense_MutationnovelV433I0.13
BRCAchrX47169471Silentrs374011478D58D0.34
BRCAchrX47181324Missense_MutationnovelS453C0.08
BRCAchrX47186573Missense_MutationNAV923M0.17
BRCAchrX47169434Missense_Mutationrs782523524R46H0.41
BRCAchrX47169378SilentNAG27G0.13
BRCAchrX47175037Missense_MutationnovelA174V0.11
BRCAchrX47176550SilentNAP209P0.21
BRCAchrX471866963'UTRNA0.48
CESCchrX471454805'UTRnovel0.47
CESCchrX47175035SilentNAF173F0.19
CESCchrX47175035SilentNAF173F0.22
CESCchrX47185757Silentrs372362761N799N0.39
CESCchrX47145509Intronnovel0.22
CESCchrX47181751Splice_Regionrs782356345S526S0.22
CESCchrX471866263'UTRnovel0.1
CESCchrX471866273'UTRnovel0.1
CESCchrX47181765Missense_MutationNAS531L0.28
CESCchrX47179125Missense_MutationNAR229H0.42
CESCchrX47181292SilentnovelE442E0.31
CESCchrX47169494Missense_MutationnovelA66V0.28
CESCchrX47185057Splice_RegionnovelI651I0.44
CESCchrX47180022SilentnovelI348I0.49
CESCchrX47181553SilentNAQ494Q0.37
CESCchrX471451535'UTRnovel0.12
CESCchrX47186356Missense_Mutationrs782214369R879H0.15
CESCchrX47182293SilentnovelK639K0.22
COADchrX47181566Missense_Mutationrs781843473A499T0.26
COADchrX47179970Frame_Shift_InsNAR332Afs*490.42
COADchrX47186156Missense_Mutationrs142585482I841T0.07
COADchrX47169328Missense_MutationnovelD11N0.09
COADchrX47185589Missense_MutationnovelE772K0.2
COADchrX47185536Missense_MutationNAT754N0.16
COADchrX47175028Frame_Shift_DelNAG172Afs*940.86
COADchrX47180454Missense_MutationNAA399V0.29
COADchrX47173152Missense_MutationnovelG153S0.21
COADchrX47169340Missense_MutationNAR15C0.54
COADchrX47181992Missense_MutationnovelG579S0.06
COADchrX47173126Splice_SitenovelX145_splice0.61
COADchrX47181959Missense_MutationNAD568N0.12
COADchrX47179975Missense_MutationnovelV333I0.44
COADchrX47186101Nonsense_MutationNAE823*0.66
COADchrX47169416Missense_MutationnovelD40G0.07
COADchrX47185320Nonsense_MutationNAQ707*0.91
DLBCchrX47186346Missense_MutationnovelG876S0.08
ESCAchrX47179910Missense_MutationnovelS311N0.88
ESCAchrX47185566Missense_MutationnovelC764F0.53
ESCAchrX47182207Nonsense_MutationnovelE611*0.85
ESCAchrX471866453'UTRnovel0.2
GBMchrX47147486Missense_MutationnovelE2G0.33
GBMchrX47175041SilentNAF175F0.28
GBMchrX47180243Missense_MutationnovelA365V0.48
GBMchrX47179975Missense_MutationnovelV333I0.93
GBMchrX47181962Missense_Mutationrs782440714V569I0.2
HNSCchrX47175021Nonsense_MutationnovelQ169*0.15
HNSCchrX47175044SilentnovelV176V0.46
HNSCchrX47185734Missense_MutationnovelR792W0.22
HNSCchrX471473895'UTRnovel0.28
KICHchrX47181867Splice_SiteNAX565_splice0.76
KIRPchrX47185334Missense_MutationnovelM711I0.28
LGGchrX47185463Missense_MutationnovelA730T0.57
LGGchrX47179893SilentnovelR305R0.55
LIHCchrX47181772SilentnovelA533A0.89
LIHCchrX47181775In_Frame_DelnovelK536_L539del0.89
LIHCchrX47169483Missense_MutationnovelE62D0.63
LIHCchrX47179935In_Frame_DelnovelL320_Y323del0.23
LUADchrX47186152Frame_Shift_DelnovelG840Afs*70.09
LUADchrX47185788Nonsense_MutationNAE810*0.35
LUADchrX47185196Nonsense_MutationNAE698*0.58
LUADchrX47179162Splice_SitenovelX241_splice0.31
LUADchrX47181956Frame_Shift_DelnovelD568Tfs*1360.6
LUADchrX47169344Frame_Shift_InsnovelG17Wfs*40.53
LUADchrX47179369Frame_Shift_DelnovelP259Hfs*70.78
LUADchrX47181608Nonsense_MutationNAE513*0.44
LUADchrX47175090Nonsense_MutationNAQ192*0.67
LUADchrX47169451Nonsense_MutationnovelE52*0.48
LUADchrX47185758Nonsense_MutationNAE800*0.46
LUADchrX47169339Frame_Shift_DelnovelR15Afs*1190.35
LUADchrX47182263Frame_Shift_InsnovelA631Gfs*420.33
LUADchrX47169414Frame_Shift_DelnovelD40Tfs*940.29
LUADchrX47185124Nonsense_MutationNAQ674*0.59
LUADchrX47179932SilentnovelG318G0.5
LUADchrX47175045Nonsense_MutationNAE177*0.49
LUADchrX47180505Missense_MutationNAQ416L0.33
LUADchrX47179384Nonsense_MutationnovelE264*0.59
LUADchrX47181961Frame_Shift_DelnovelV569Yfs*60.49
LUADchrX47173158Nonsense_MutationNAQ155*0.24
LUADchrX47186328Missense_MutationNAG870C0.5
LUADchrX47185077Nonsense_MutationnovelW658*0.58
LUADchrX47185078Missense_MutationnovelW658C0.58
LUADchrX47182262Missense_MutationNAT629I0.23
LUADchrX47175093Splice_SiteNAX192_splice0.44
LUADchrX47181973Nonsense_MutationnovelY572*0.25
LUADchrX47169442Missense_MutationNAG49S0.37
LUADchrX47186493Missense_MutationNAG896V0.29
LUADchrX47185301Splice_SitenovelX701_splice0.57
LUADchrX47185792Splice_SitenovelX810_splice0.39
LUADchrX47175018Splice_SiteNAX168_splice0.44
LUADchrX47182255Frame_Shift_DelnovelK627Rfs*770.16
LUADchrX47181848Nonsense_MutationNAE559*0.52
LUADchrX471866793'UTRnovel0.58
LUADchrX47175070Frame_Shift_InsnovelR186Tfs*230.69
LUADchrX47185617Missense_MutationNAS781L0.67
LUADchrX47181524Nonsense_MutationNAE485*0.67
LUADchrX47180417Splice_SiteNAX387_splice0.17
LUADchrX47175018Splice_SiteNAX168_splice0.74
LUADchrX47169492Frame_Shift_DelnovelS65Rfs*690.17
LUADchrX47173152Missense_MutationNAG153C0.36
LUADchrX47173183Frame_Shift_DelnovelN164Tfs*1020.71
LUSCchrX47182172In_Frame_DelnovelN599_A600delinsT0.34
LUSCchrX47181985SilentnovelE576E0.73
LUSCchrX47171081SilentnovelR85R0.88
LUSCchrX47171156Missense_MutationnovelE110D0.29
LUSCchrX47185326Missense_MutationNAT709A0.54
LUSCchrX47180434Missense_MutationnovelN392K0.47
LUSCchrX47181578Missense_MutationnovelA503P0.35
LUSCchrX47181810Missense_MutationnovelS546I0.16
LUSCchrX47180008Missense_MutationnovelG344C0.09
OVchrX47186168Missense_MutationnovelS845Y0.23
OVchrX47186108Missense_MutationnovelY825C0.17
OVchrX47182274Missense_MutationnovelS633L0.47
OVchrX47185142Nonsense_MutationnovelR680*0.51
PAADchrX47179414Frame_Shift_DelnovelQ274Sfs*340.35
PAADchrX47179416Frame_Shift_DelnovelQ274Hfs*340.37
PAADchrX47185715Splice_SitenovelX786_splice0.2
PAADchrX47179890Frame_Shift_DelnovelL304Ffs*40.38
PAADchrX47179127Nonsense_MutationNAR230*0.09
PAADchrX47180445Missense_MutationNAR396H0.2
PRADchrX47181972Frame_Shift_InsnovelD575Pfs*40.43
PRADchrX47180295SilentNAA382A0.68
PRADchrX47171211Missense_MutationnovelN129D0.88
READchrX47185734Missense_MutationnovelR792W0.54
READchrX47186515SilentnovelG903G0.84
READchrX47147483Translation_Start_SitenovelM1?0.48
READchrX47181221Nonsense_MutationNAQ419*0.49
READchrX47169391Nonsense_MutationNAR32*0.71
READchrX47185609SilentNAQ778Q0.1
SARCchrX47176548Missense_MutationnovelP209S0.19
SARCchrX471474625'UTRnovel0.32
SKCMchrX47176568SilentnovelE215E0.42
SKCMchrX47185343Silentrs782730454P714P0.24
SKCMchrX47185738Missense_MutationnovelR793Q0.29
SKCMchrX47176521Nonsense_MutationNAQ200*0.34
SKCMchrX47186139SilentnovelR835R0.44
SKCMchrX47181797Missense_MutationNAP542S0.11
SKCMchrX47186079SilentnovelR815R1
SKCMchrX47186080Missense_MutationnovelD816N1
SKCMchrX47175027Missense_MutationNAR171W0.87
SKCMchrX47185070Missense_MutationNAE656K0.31
SKCMchrX47185758Missense_MutationnovelE800K0.38
SKCMchrX47176568Missense_MutationNAE215D0.16
SKCMchrX47179922Missense_MutationNAS315F0.26
SKCMchrX47182288Missense_MutationnovelE638K1
SKCMchrX47180277SilentNAT376T1
STADchrX47186356Missense_Mutationrs782214369R879H0.36
STADchrX47181565Silentrs782746949R498R0.64
STADchrX47186098Frame_Shift_DelnovelR822Kfs*360.14
STADchrX47179945Frame_Shift_DelnovelY323Tfs*120.63
STADchrX47181959Missense_MutationNAD568N0.38
STADchrX47185058Missense_MutationNAA652T0.44
STADchrX47171172In_Frame_DelnovelD120_E124del0.42
STADchrX47171180Missense_MutationNAE118D0.37
STADchrX47185128Missense_MutationNAP675H0.45
STADchrX47169459Missense_MutationNAK54N0.2
STADchrX47179381Missense_MutationNAR263W0.53
STADchrX47185204Splice_RegionnovelK700K0.71
STADchrX47171149Missense_MutationNAR108Q0.27
STADchrX47171165SilentNAE113E0.28
THCAchrX47171165SilentNAE113E0.13
THCAchrX47185749Frame_Shift_DelnovelS797*0.09
THCAchrX47179965SilentnovelS329S0.12
UCECchrX47181964Silentrs782720481V569V0.24
UCECchrX47185103Nonsense_MutationNAE667*0.31
UCECchrX471451585'UTRnovel0.13
UCECchrX47181245Missense_MutationnovelT427A0.18
UCECchrX47186264Silentrs782028481F848F0.29
UCECchrX47179968SilentNAN330N0.17
UCECchrX47186264Silentrs782028481F848F0.38
UCECchrX47181340Silentrs782676673G458G0.41
UCECchrX47175072Nonsense_MutationNAR186*0.41
UCECchrX47186489Missense_Mutationrs782671192R895W0.5
UCECchrX47171124Missense_MutationnovelG100S0.5
UCECchrX471452095'UTRnovel0.14
UCECchrX47182275Silentrs201100351S633S0.19
UCECchrX47185615SilentnovelL780L0.34
UCECchrX47186264Silentrs782028481F848F0.23
UCECchrX47171037Missense_MutationnovelE71K0.41
UCECchrX47181613Silentrs370783292A514A0.33
UCECchrX47186310Missense_MutationNAR864W0.24
UCECchrX471473715'UTRnovel0.16
UCECchrX47181571SilentnovelQ500Q0.18
UCECchrX47186166SilentNAA844A0.73
UCECchrX47182246Missense_MutationNAD624N0.09
UCECchrX47186265Missense_MutationnovelE849K0.14
UCECchrX471452445'UTRnovel0.35
UCECchrX47181347Missense_MutationnovelK461E0.33
UCECchrX47181513Missense_MutationnovelE481G0.31
UCECchrX47181590Missense_MutationnovelI507V0.1
UCECchrX471450715'UTRnovel0.31
UCECchrX47181597Missense_MutationnovelQ509R0.3
UCECchrX471867243'UTRnovel0.39
UCECchrX47171074Missense_MutationNAR83Q0.71
UCECchrX47179974SilentNAR332R0.47
UCECchrX47186365Missense_MutationNAQ882R0.16
UCECchrX47180287Missense_MutationNAE380K0.13
UCECchrX47181866Missense_MutationnovelP565T0.34
UCECchrX47175045Missense_MutationnovelE177K0.4
UCECchrX47180261Missense_MutationnovelT371N0.59
UCECchrX47185767Missense_MutationnovelA803T0.39
UCECchrX47169494Missense_MutationnovelA66V0.6
UCECchrX47171156Missense_MutationnovelE110D0.47
UCECchrX47180460Missense_MutationnovelS401Y0.49
UCECchrX471452565'UTRnovel0.39
UCECchrX47181981Missense_MutationNAD575V0.39
UCECchrX47171259Splice_Siters782679832X144_splice0.42
UCECchrX47147497Missense_MutationNAR6C0.31
UCECchrX47169460Missense_MutationnovelH55Y0.12
UCECchrX47171218Missense_MutationnovelV131A0.4
UCECchrX471450695'UTRnovel0.31
UCECchrX47179934Missense_MutationnovelA319V0.46
UCECchrX47182281Missense_MutationNAE635D0.04
UCECchrX47175045Missense_MutationnovelE177K0.18
UCECchrX47180010SilentnovelG344G0.19
UCECchrX47171033SilentnovelS69S0.4
UCECchrX47186264Silentrs782028481F848F0.29
UCECchrX471868073'UTRnovel0.5
UCECchrX47169386Missense_MutationnovelR30H0.33
UCECchrX47179985Missense_MutationnovelD336G0.57
UCECchrX47182250Missense_MutationnovelG625E0.33
UCECchrX47186510Missense_Mutationrs782208940R902W0.51
UCECchrX47180445Missense_MutationNAR396H0.1
UCECchrX47169474SilentnovelD59D0.39
UCECchrX47181258Missense_Mutationrs11551150P431L0.39
UCECchrX47181966Missense_MutationnovelS570Y0.29
UCECchrX47186339Missense_MutationnovelE873D0.46
UCECchrX471866403'UTRnovel0.26
UCECchrX47173164Missense_Mutationrs782660136R157W0.07
UCECchrX47181523SilentnovelL484L0.28
UCECchrX47171099Silentrs782211187T91T0.18
UCECchrX47185314Missense_MutationNAE705K0.24
UCECchrX47185343Silentrs782730454P714P0.26
UCECchrX47181763Missense_MutationnovelM530I0.4
UCECchrX47182221SilentnovelY615Y0.53
UCECchrX47147496Splice_RegionNAR5R0.33
UCECchrX47169385Missense_Mutationrs782008653R30C0.4
UCECchrX47181509Missense_MutationnovelP480S0.4
UCECchrX47186076SilentnovelY814Y0.16
UCECchrX47145492Splice_Regionnovel0.59
UCECchrX471452465'UTRnovel0.36
UCECchrX471453785'UTRnovel0.3
UCECchrX47169386Missense_MutationnovelR30H0.37
UCECchrX471451145'UTRnovel0.37
UCECchrX47186166SilentNAA844A0.37
UCECchrX471866713'UTRnovel0.39
UVMchrX47179964Frame_Shift_DelnovelV331*0.25
UVMchrX47179908In_Frame_DelnovelS311_T312del0.33

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
SARCAMP0.30350.19108
THCADEL0.0020.21991
UCECAMP0.09280.012518

Survival Analysis
CancerP-value Q-value
KIRC0.00012

Kaplan-Meier Survival Analysis

STAD0.041

Kaplan-Meier Survival Analysis

SARC0.0098

Kaplan-Meier Survival Analysis

ACC0.00096

Kaplan-Meier Survival Analysis

UCS0.014

Kaplan-Meier Survival Analysis

HNSC0.025

Kaplan-Meier Survival Analysis

SKCM0.03

Kaplan-Meier Survival Analysis

KIRP0.0023

Kaplan-Meier Survival Analysis

COAD0.026

Kaplan-Meier Survival Analysis

PAAD0.0001

Kaplan-Meier Survival Analysis

BLCA0.0037

Kaplan-Meier Survival Analysis

CESC0.0011

Kaplan-Meier Survival Analysis

LIHC0.0013

Kaplan-Meier Survival Analysis

UVM0.019

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • PPI
  • Paralogs
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000182872 (Gene tree)
Gene ID
8241
Gene Symbol
RBM10
Alias
DXS8237E|KIAA0122|GPATC9|ZRANB5|GPATCH9|S1-1
Full Name
RNA binding motif protein 10
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
41,947 bases
Position
chrX:47,144,869-47,186,815
Accession
9896
RBP type
canonical RBP
Summary
This gene encodes a nuclear protein that belongs to a family proteins that contain an RNA-binding motif. The encoded protein associates with hnRNP proteins and may be involved in regulating alternative splicing. Defects in this gene are the cause of the X-linked recessive disorder, TARP syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2011]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000486115zf-RanBPPF00641.184e-0611
ENSP00000329659zf-RanBPPF00641.184e-0611
ENSP00000366829zf-RanBPPF00641.184.5e-0611
ENSP00000328848zf-RanBPPF00641.184.9e-0611
ENSP00000366829RRM_1PF00076.222e-1211
ENSP00000328848RRM_1PF00076.222.3e-1211
ENSP00000486115RRM_1PF00076.221.4e-0911
ENSP00000329659RRM_1PF00076.221.8e-0911
ENSP00000486115G-patchPF01585.234.1e-1811
ENSP00000329659G-patchPF01585.234.1e-1811
ENSP00000366829G-patchPF01585.234.5e-1811
ENSP00000328848G-patchPF01585.234.9e-1811
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
18315527S1-1 nuclear domains: characterization and dynamics as a function of transcriptional activity.Biol Cell2008 SepInoue Adoi: 10.1042/BC20070142.
21256132Characterization of a family of RanBP2-type zinc fingers that can recognize single-stranded RNA.J Mol Biol2011 Mar 25Nguyen CDdoi: 10.1016/j.jmb.2010.12.041
26853560Tumor suppressor properties of the splicing regulatory factor RBM10.RNA Biol2016Hernandez Jdoi: 10.1080/15476286.2016.1144004.
29085465Increased cell apoptosis in human lung adenocarcinoma and in vivo tumor growth inhibition by RBM10, a tumor suppressor gene.Oncol Lett2017 OctJi Ydoi: 10.3892/ol.2017.6765
30955253RBM10 inhibits cell proliferation of lung adenocarcinoma via RAP1/AKT/CREB signalling pathway.J Cell Mol Med2019 JunJin Xdoi: 10.1111/jcmm.14263
24530524RBM10 regulates alternative splicing.FEBS Lett2014 Mar 18Inoue Adoi: 10.1016/j.febslet.2014.01.052
28379442An RRM-ZnF RNA recognition module targets RBM10 to exonic sequences to promote exon exclusion.Nucleic Acids Res2017 Jun 20Collins KMdoi: 10.1093/nar/gkx225.
8760884Molecular cloning of a RNA binding protein, S1-1.Nucleic Acids Res1996 Aug 1Inoue A-
23294349S1-1/RBM10: multiplicity and cooperativity of nuclear localisation domains.Biol Cell2013 AprXiao SJdoi: 10.1111/boc.201200068
21737612mRNA expression of the putative antimetastatic gene BRMS1 and of apoptosis-related genes in breast cancer.Cancer Genomics Proteomics2011 Jul-AugSchneider J-
20451169Massively parallel sequencing of exons on the X chromosome identifies RBM10 as the gene that causes a syndromic form of cleft palate.Am J Hum Genet2010 May 14Johnston JJdoi: 10.1016/j.ajhg.2010.04.007
25586139The nuclear splicing factor RNA binding motif 5 promotes caspase activation in human neuronal cells, and increases after traumatic brain injury in mice.J Cereb Blood Flow Metab2015 Mar 31Jackson TCdoi: 10.1038/jcbfm.2014.242.
24332178RBM5, 6, and 10 differentially regulate NUMB alternative splicing to control cancer cell proliferation.Mol Cell2013 Dec 12Bechara EGdoi: 10.1016/j.molcel.2013.11.010.
24000153Integrative analysis revealed the molecular mechanism underlying RBM10-mediated splicing regulation.EMBO Mol Med2013 SepWang Ydoi: 10.1002/emmm.201302663
27763814The RNA-binding landscape of RBM10 and its role in alternative splicing regulation in models of mouse early development.RNA Biol2017 Jan 2Rodor Jdoi: 10.1080/15476286.2016.1247148
26712279Nuclear Magnetic Resonance Structure of a Novel Globular Domain in RBM10 Containing OCRE, the Octamer Repeat Sequence Motif.Structure2016 Jan 5Martin BTdoi: 10.1016/j.str.2015.10.029
26784654Co- and post-transcriptional regulation of Rbm5 and Rbm10 in mouse cells as evidenced by tissue-specific, developmental and disease-associated variation of splice variant and protein expression levels.Gene2016 Apr 10Ozuemba Bdoi: 10.1016/j.gene.2015.12.070
26751795Src Family Tyrosine Kinase Signaling Regulates FilGAP through Association with RBM10.PLoS One2016 Jan 11Yamada Hdoi: 10.1371/journal.pone.0146593
26446321RBM10 Modulates Apoptosis and Influences TNF-α Gene Expression.J Cell Death2012 Jan 27Wang Kdoi: 10.4137/JCD.S9073
25889998Insight into the role of alternative splicing within the RBM10v1 exon 10 tandem donor site.BMC Res Notes2015 Feb 19Tessier SJdoi: 10.1186/s13104-015-0983-5.
28577551Clinical diagnostic exome evaluation for an infant with a lethal disorder: genetic diagnosis of TARP syndrome and expansion of the phenotype in a patient with a newly reported RBM10 alteration.BMC Med Genet2017 Jun 2Powis Zdoi: 10.1186/s12881-017-0426-3.
28586478Autoregulation of RBM10 and cross-regulation of RBM10/RBM5 via alternative splicing-coupled nonsense-mediated decay.Nucleic Acids Res2017 Aug 21Sun Ydoi: 10.1093/nar/gkx508.
28662214RBM10 promotes transformation-associated processes in small cell lung cancer and is directly regulated by RBM5.PLoS One2017 Jun 29Loiselle JJdoi: 10.1371/journal.pone.0180258
28728573Splicing arrays reveal novel RBM10 targets, including SMN2 pre-mRNA.BMC Mol Biol2017 Jul 20Sutherland LCdoi: 10.1186/s12867-017-0096-x.
29274279RBM10: Harmful or helpful-many factors to consider.J Cell Biochem2018 MayLoiselle JJdoi: 10.1002/jcb.26644
29309623Rbm10 regulates inflammation development via alternative splicing of Dnmt3b.Int Immunol2017 Dec 31Atsumi Tdoi: 10.1093/intimm/dxx067.
29450990Splicing Site Recognition by Synergy of Three Domains in Splicing Factor RBM10.Biochemistry2018 Mar 13Serrano Pdoi: 10.1021/acs.biochem.7b01242
30189253TARP syndrome: Long-term survival, anatomic patterns of congenital heart defects, differential diagnosis and pathogenetic considerations.Eur J Med Genet2019 JunNiceta Mdoi: 10.1016/j.ejmg.2018.09.001
30257214A Splicing-Independent Function of RBM10 Controls Specific 3' UTR Processing to Regulate Cardiac Hypertrophy.Cell Rep2018 Sep 25Mohan Ndoi: 10.1016/j.celrep.2018.08.077.
30483773Functional role of RBM10 in lung adenocarcinoma proliferation.Int J Oncol2019 FebSun Xdoi: 10.3892/ijo.2018.4643
30803556RBM10 truncation in astroblastoma in a patient with history of mandibular ameloblastoma: A case report.Cancer Genet2019 FebMajd NKdoi: 10.1016/j.cancergen.2019.01.001
30908700RBM10-TFE3 renal cell carcinoma characterised by paracentric inversion with consistent closely split signals in break-apart fluorescence in-situ hybridisation: study of 10 cases and a literature review.Histopathology2019 AugKato Idoi: 10.1111/his.13866
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000377604RBM10-2033747XM_024452459ENSP00000366829930 (aa)XP_024308227P98175
ENST00000329236RBM10-2013201XM_005272677ENSP00000328848995 (aa)XP_005272734P98175
ENST00000345781RBM10-2023108XM_017029884ENSP00000329659853 (aa)XP_016885373P98175
ENST00000496012RBM10-205509--- (aa)--
ENST00000478410RBM10-204847--- (aa)--
ENST00000628161RBM10-2063105XM_017029885ENSP00000486115852 (aa)XP_016885374P98175
Gene Model
Click here to download ENSG00000182872's gene model file
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000182872's network

* RBP PPI network refers to all genes directly bind to RBP
Paralogs
Ensembl IDGene SymbolCoverageIdentiy ParalogGene SymbolCoverageIdentiy
ENSG00000182872RBM109851.765ENSG00000003756RBM59850.378
ENSG00000182872RBM106933.509ENSG00000004534RBM68933.067
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000182872RBM109051.189ENSAPOG00000018220rbm107753.160Acanthochromis_polyacanthus
ENSG00000182872RBM10100100.000ENSAMEG00000012961RBM1010096.389Ailuropoda_melanoleuca
ENSG00000182872RBM107259.677ENSACIG00000013859rbm109662.678Amphilophus_citrinellus
ENSG00000182872RBM107954.880ENSAOCG00000022677rbm107655.850Amphiprion_ocellaris
ENSG00000182872RBM109052.513ENSAPEG00000005675rbm107753.408Amphiprion_percula
ENSG00000182872RBM109357.447ENSATEG00000023522rbm107853.521Anabas_testudineus
ENSG00000182872RBM109975.391ENSACAG00000005527RBM109976.538Anolis_carolinensis
ENSG00000182872RBM1010098.507ENSANAG00000026392-10097.410Aotus_nancymaae
ENSG00000182872RBM109992.063ENSANAG00000033026-10092.308Aotus_nancymaae
ENSG00000182872RBM109250.119ENSACLG00000008773rbm107852.625Astatotilapia_calliptera
ENSG00000182872RBM1010098.507ENSBTAG00000002890RBM1010098.507Bos_taurus
ENSG00000182872RBM1010099.062ENSCJAG00000012101RBM1010098.794Callithrix_jacchus
ENSG00000182872RBM10100100.000ENSCAFG00000014863RBM109998.042Canis_familiaris
ENSG00000182872RBM10100100.000ENSCAFG00020021417RBM109298.150Canis_lupus_dingo
ENSG00000182872RBM109995.455ENSCHIG00000000855RBM109898.000Capra_hircus
ENSG00000182872RBM10100100.000ENSTSYG00000030341RBM10100100.000Carlito_syrichta
ENSG00000182872RBM1079100.000ENSCAPG00000013182RBM1095100.000Cavia_aperea
ENSG00000182872RBM1010098.507ENSCPOG00000002939RBM1010097.852Cavia_porcellus
ENSG00000182872RBM1010099.297ENSCCAG00000025788RBM1010099.297Cebus_capucinus
ENSG00000182872RBM10100100.000ENSCATG00000018553RBM10100100.000Cercocebus_atys
ENSG00000182872RBM1010098.507ENSCLAG00000001238RBM1010098.507Chinchilla_lanigera
ENSG00000182872RBM10100100.000ENSCSAG00000013744RBM1010099.698Chlorocebus_sabaeus
ENSG00000182872RBM108576.027ENSCPBG00000000458RBM109677.397Chrysemys_picta_bellii
ENSG00000182872RBM10100100.000ENSCANG00000000359RBM10100100.000Colobus_angolensis_palliatus
ENSG00000182872RBM1010096.249ENSCGRG00001017158Rbm1010096.249Cricetulus_griseus_chok1gshd
ENSG00000182872RBM1010096.249ENSCGRG00000011339Rbm1010096.249Cricetulus_griseus_crigri
ENSG00000182872RBM108654.313ENSCVAG00000009548rbm107753.503Cyprinodon_variegatus
ENSG00000182872RBM108256.982ENSDARG00000077400rbm1010071.898Danio_rerio
ENSG00000182872RBM107098.006ENSDNOG00000031259RBM109698.006Dasypus_novemcinctus
ENSG00000182872RBM1010098.507ENSDORG00000015022Rbm1010098.507Dipodomys_ordii
ENSG00000182872RBM109992.630ENSETEG00000003131RBM109092.630Echinops_telfairi
ENSG00000182872RBM109698.361ENSEASG00005014310RBM109798.000Equus_asinus_asinus
ENSG00000182872RBM10100100.000ENSECAG00000000287RBM1097100.000Equus_caballus
ENSG00000182872RBM105397.491ENSEEUG00000008271-5397.491Erinaceus_europaeus
ENSG00000182872RBM108652.246ENSELUG00000019845rbm109849.006Esox_lucius
ENSG00000182872RBM1010098.507ENSFCAG00000001395RBM1010098.507Felis_catus
ENSG00000182872RBM1010098.507ENSFDAG00000002328RBM1010098.067Fukomys_damarensis
ENSG00000182872RBM108654.727ENSFHEG00000021050rbm107954.051Fundulus_heteroclitus
ENSG00000182872RBM105955.058ENSGMOG00000011093rbm1010055.447Gadus_morhua
ENSG00000182872RBM105955.086ENSGACG00000009953rbm1010056.564Gasterosteus_aculeatus
ENSG00000182872RBM1010078.714ENSGAGG00000001747RBM1010078.925Gopherus_agassizii
ENSG00000182872RBM10100100.000ENSGGOG00000007869RBM1010099.899Gorilla_gorilla
ENSG00000182872RBM109249.881ENSHBUG00000000175rbm107852.503Haplochromis_burtoni
ENSG00000182872RBM1010098.507ENSHGLG00000000890RBM1010098.507Heterocephalus_glaber_female
ENSG00000182872RBM109998.246ENSHGLG00100001369RBM109898.000Heterocephalus_glaber_male
ENSG00000182872RBM109050.257ENSHCOG00000002211rbm107850.567Hippocampus_comes
ENSG00000182872RBM108247.361ENSIPUG00000014280rbm109448.942Ictalurus_punctatus
ENSG00000182872RBM10100100.000ENSSTOG00000014369RBM10100100.000Ictidomys_tridecemlineatus
ENSG00000182872RBM10100100.000ENSJJAG00000014158Rbm1098100.000Jaculus_jaculus
ENSG00000182872RBM108652.202ENSKMAG00000019926rbm107850.854Kryptolebias_marmoratus
ENSG00000182872RBM109051.368ENSLBEG00000007620rbm107752.158Labrus_bergylta
ENSG00000182872RBM109963.750ENSLACG00000005251RBM109963.257Latimeria_chalumnae
ENSG00000182872RBM108257.595ENSLOCG00000014304rbm109757.795Lepisosteus_oculatus
ENSG00000182872RBM109997.300ENSLAFG00000002900RBM109997.300Loxodonta_africana
ENSG00000182872RBM10100100.000ENSMFAG00000032405RBM10100100.000Macaca_fascicularis
ENSG00000182872RBM10100100.000ENSMMUG00000017423RBM10100100.000Macaca_mulatta
ENSG00000182872RBM10100100.000ENSMNEG00000038904RBM10100100.000Macaca_nemestrina
ENSG00000182872RBM10100100.000ENSMLEG00000042685RBM10100100.000Mandrillus_leucophaeus
ENSG00000182872RBM109050.125ENSMAMG00000008925rbm107851.415Mastacembelus_armatus
ENSG00000182872RBM109250.119ENSMZEG00005027122rbm107852.625Maylandia_zebra
ENSG00000182872RBM1010096.835ENSMAUG00000011595Rbm1010097.015Mesocricetus_auratus
ENSG00000182872RBM1010098.593ENSMICG00000016937RBM1010098.593Microcebus_murinus
ENSG00000182872RBM1010097.015ENSMOCG00000022485Rbm1010096.459Microtus_ochrogaster
ENSG00000182872RBM109085.507ENSMODG00000010640RBM1010081.717Monodelphis_domestica
ENSG00000182872RBM109051.737ENSMALG00000011917rbm107752.457Monopterus_albus
ENSG00000182872RBM1010097.015MGP_CAROLIEiJ_G0032963Rbm1010097.015Mus_caroli
ENSG00000182872RBM1010097.015ENSMUSG00000031060Rbm1010097.015Mus_musculus
ENSG00000182872RBM1010098.507MGP_PahariEiJ_G0031506Rbm1010098.507Mus_pahari
ENSG00000182872RBM1010097.015MGP_SPRETEiJ_G0034113Rbm1010097.015Mus_spretus
ENSG00000182872RBM10100100.000ENSMPUG00000013129RBM109297.636Mustela_putorius_furo
ENSG00000182872RBM106690.123ENSMLUG00000013095RBM1010090.123Myotis_lucifugus
ENSG00000182872RBM1010098.507ENSNGAG00000019664Rbm1010098.507Nannospalax_galili
ENSG00000182872RBM1096100.000ENSNLEG00000003018RBM10100100.000Nomascus_leucogenys
ENSG00000182872RBM108785.135ENSMEUG00000009028RBM108684.561Notamacropus_eugenii
ENSG00000182872RBM1050100.000ENSOPRG00000005550-50100.000Ochotona_princeps
ENSG00000182872RBM1010098.507ENSODEG00000008955RBM1010098.507Octodon_degus
ENSG00000182872RBM109250.119ENSONIG00000012370rbm109952.083Oreochromis_niloticus
ENSG00000182872RBM1010088.235ENSOANG00000004552RBM109788.235Ornithorhynchus_anatinus
ENSG00000182872RBM1010098.507ENSOCUG00000006454RBM1010095.923Oryctolagus_cuniculus
ENSG00000182872RBM108551.862ENSORLG00000008657rbm107750.993Oryzias_latipes
ENSG00000182872RBM108552.064ENSORLG00020004636rbm107751.180Oryzias_latipes_hni
ENSG00000182872RBM108552.000ENSORLG00015021021rbm107651.454Oryzias_latipes_hsok
ENSG00000182872RBM108551.197ENSOMEG00000014309rbm107750.062Oryzias_melastigma
ENSG00000182872RBM1010098.507ENSOGAG00000008550RBM1010098.090Otolemur_garnettii
ENSG00000182872RBM1010098.507ENSOARG00000013674RBM109988.012Ovis_aries
ENSG00000182872RBM10100100.000ENSPPAG00000040583RBM10100100.000Pan_paniscus
ENSG00000182872RBM1010098.507ENSPPRG00000023784RBM1010098.507Panthera_pardus
ENSG00000182872RBM108398.630ENSPTIG00000017219RBM109498.630Panthera_tigris_altaica
ENSG00000182872RBM10100100.000ENSPTRG00000021837RBM1010099.799Pan_troglodytes
ENSG00000182872RBM10100100.000ENSPANG00000013608RBM1010099.598Papio_anubis
ENSG00000182872RBM108157.300ENSPKIG00000007372rbm109955.389Paramormyrops_kingsleyae
ENSG00000182872RBM1010097.015ENSPEMG00000012165Rbm1010097.015Peromyscus_maniculatus_bairdii
ENSG00000182872RBM1010084.060ENSPCIG00000027962RBM1010084.060Phascolarctos_cinereus
ENSG00000182872RBM108252.120ENSPFOG00000005428rbm109753.258Poecilia_formosa
ENSG00000182872RBM109350.183ENSPLAG00000013887rbm107752.453Poecilia_latipinna
ENSG00000182872RBM109349.939ENSPMEG00000005032rbm107752.345Poecilia_mexicana
ENSG00000182872RBM109350.670ENSPREG00000019319rbm108153.097Poecilia_reticulata
ENSG00000182872RBM10100100.000ENSPPYG00000020285RBM1010095.269Pongo_abelii
ENSG00000182872RBM108794.993ENSPCAG00000000239RBM109389.711Procavia_capensis
ENSG00000182872RBM10100100.000ENSPCOG00000023562RBM10100100.000Propithecus_coquereli
ENSG00000182872RBM107998.507ENSPVAG00000006787RBM108098.507Pteropus_vampyrus
ENSG00000182872RBM109250.000ENSPNYG00000015230rbm107852.503Pundamilia_nyererei
ENSG00000182872RBM108156.780ENSPNAG00000011074rbm107756.016Pygocentrus_nattereri
ENSG00000182872RBM1010098.507ENSRNOG00000008472Rbm1010098.507Rattus_norvegicus
ENSG00000182872RBM10100100.000ENSRBIG00000040371RBM10100100.000Rhinopithecus_bieti
ENSG00000182872RBM10100100.000ENSRROG00000043355RBM10100100.000Rhinopithecus_roxellana
ENSG00000182872RBM1010099.297ENSSBOG00000022873RBM1010099.297Saimiri_boliviensis_boliviensis
ENSG00000182872RBM1010085.507ENSSHAG00000007724-9485.507Sarcophilus_harrisii
ENSG00000182872RBM108656.387ENSSFOG00015010701rbm107655.678Scleropages_formosus
ENSG00000182872RBM109050.498ENSSMAG00000006556rbm107751.553Scophthalmus_maximus
ENSG00000182872RBM109051.746ENSSLDG00000001390rbm107752.528Seriola_lalandi_dorsalis
ENSG00000182872RBM109798.507ENSSARG00000014122RBM108998.507Sorex_araneus
ENSG00000182872RBM106081.879ENSSPUG00000006952RBM108981.879Sphenodon_punctatus
ENSG00000182872RBM108648.902ENSSPAG00000004647rbm109348.840Stegastes_partitus
ENSG00000182872RBM109997.644ENSSSCG00000012271RBM109997.644Sus_scrofa
ENSG00000182872RBM109349.822ENSTRUG00000010215rbm107951.779Takifugu_rubripes
ENSG00000182872RBM109450.993ENSTNIG00000015014rbm109851.242Tetraodon_nigroviridis
ENSG00000182872RBM107497.665ENSTBEG00000005519RBM108097.665Tupaia_belangeri
ENSG00000182872RBM1010098.507ENSTTRG00000013653RBM109798.507Tursiops_truncatus
ENSG00000182872RBM1096100.000ENSUAMG00000026047RBM1098100.000Ursus_americanus
ENSG00000182872RBM1010098.507ENSVVUG00000014315RBM1010095.811Vulpes_vulpes
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000122negative regulation of transcription by RNA polymerase II-IEAProcess
GO:0000381regulation of alternative mRNA splicing, via spliceosome-IEAProcess
GO:0003723RNA binding22658674.HDAFunction
GO:0005515protein binding22365833.25416956.26871637.29021621.IPIFunction
GO:0005634nucleus-IDAComponent
GO:0006397mRNA processing-IEAProcess
GO:0008150biological_process-NDProcess
GO:0008285negative regulation of cell proliferation-IEAProcess
GO:0008380RNA splicing-IEAProcess
GO:0016607nuclear speck-IDAComponent
GO:0032991protein-containing complex17707232.IPIComponent
GO:0034393positive regulation of smooth muscle cell apoptotic process-IEAProcess
GO:0035198miRNA binding28431233.IDAFunction
GO:0042802identical protein binding22365833.IPIFunction
GO:0046872metal ion binding-IEAFunction
GO:0048025negative regulation of mRNA splicing, via spliceosome-IEAProcess
GO:00709353'-UTR-mediated mRNA stabilization-IEAProcess
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