EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr6	27867514	Missense_Mutation	novel	P6A	0.11
BLCA	chr6	27867430	Missense_Mutation	novel	A34T	0.28
BLCA	chr6	27867551	5'Flank	rs763089007		0.41
BLCA	chr6	27867399	Nonsense_Mutation	novel	S44*	0.44
BLCA	chr6	27867200	Silent	NA	L110L	0.2
BLCA	chr6	27867482	Silent	NA	E16E	0.69
BLCA	chr6	27866936	Silent	NA	P198P	0.27
BLCA	chr6	27867056	In_Frame_Del	rs545007006	T155_K158del	0.11
BLCA	chr6	27866878	Frame_Shift_Del	novel	*A218Pfs?**	0.22
BLCA	chr6	27866879	Missense_Mutation	novel	K217N	0.22
BLCA	chr6	27866914	Missense_Mutation	NA	A206T	0.19
BLCA	chr6	27867257	Silent	novel	V91V	0.17
BRCA	chr6	27867086	Silent	rs368971921	A148A	0.21
BRCA	chr6	27866966	Missense_Mutation	NA	K188N	0.23
BRCA	chr6	27872322	5'Flank	rs190582604		0.27
BRCA	chr6	27867101	Missense_Mutation	NA	K143N	0.33
BRCA	chr6	27871866	5'Flank	novel		0.37
BRCA	chr6	27867416	Silent	rs756173269	A38A	0.06
CESC	chr6	27867086	Silent	NA	A148A	0.25
CESC	chr6	27871894	5'Flank	rs368144811		0.23
CESC	chr6	27867551	5'Flank	rs763089007		0.21
CESC	chr6	27871886	5'Flank	novel		0.25
CESC	chr6	27866936	Silent	NA	P198P	0.33
CESC	chr6	27866966	Missense_Mutation	NA	K188N	0.45
CESC	chr6	27867186	Missense_Mutation	rs541014157	A115V	0.31
CESC	chr6	27866801	3'Flank	novel		0.42
CESC	chr6	27866966	Missense_Mutation	NA	K188N	0.37
CESC	chr6	27866936	Silent	NA	P198P	0.72
CESC	chr6	27866901	In_Frame_Del	rs758100284	P213_K217del	0.33
CESC	chr6	27867525	Missense_Mutation	NA	S2L	0.3
CESC	chr6	27866835	3'Flank	novel		0.25
CESC	chr6	27867101	Silent	rs780923320	K143K	0.29
CESC	chr6	27866981	Silent	novel	P183P	0.52
CESC	chr6	27867110	Silent	NA	K140K	0.38
CESC	chr6	27866936	Silent	NA	P198P	0.4
COAD	chr6	27867050	Silent	rs764722398	K160K	0.25
COAD	chr6	27866887	Missense_Mutation	NA	A215T	0.32
COAD	chr6	27866894	Silent	NA	K212K	0.23
COAD	chr6	27867149	Silent	novel	G127G	0.08
COAD	chr6	27867177	Frame_Shift_Ins	NA	*E118Gfs13**	0.16
COAD	chr6	27867179	Silent	novel	G117G	0.06
COAD	chr6	27867081	Missense_Mutation	NA	K150R	0.25
COAD	chr6	27866877	Missense_Mutation	rs775091070	A218V	0.09
COAD	chr6	27867151	Missense_Mutation	NA	G127S	0.29
DLBC	chr6	27867138	Missense_Mutation	rs199758872	A131V	0.3
DLBC	chr6	27867264	Missense_Mutation	rs771262830	S89N	0.17
DLBC	chr6	27867213	Missense_Mutation	novel	G106A	0.45
ESCA	chr6	27867436	Missense_Mutation	novel	G32S	0.14
ESCA	chr6	27867081	Missense_Mutation	NA	K150R	0.58
ESCA	chr6	27867467	Silent	rs758785999	K21K	0.36
ESCA	chr6	27867071	Missense_Mutation	rs776470457	K153N	0.41
ESCA	chr6	27871860	5'Flank	novel		0.59
ESCA	chr6	27867169	Missense_Mutation	novel	P121S	0.21
GBM	chr6	27867074	Silent	novel	V152V	0.1
HNSC	chr6	27867020	Silent	novel	V170V	0.31
HNSC	chr6	27867136	Missense_Mutation	novel	K132E	0.25
HNSC	chr6	27866936	Silent	NA	P198P	0.36
HNSC	chr6	27867392	Silent	rs374541448	L46L	0.22
HNSC	chr6	27866798	3'Flank	novel		0.24
HNSC	chr6	27871873	5'Flank	novel		0.2
HNSC	chr6	27867421	Missense_Mutation	novel	K37Q	0.25
HNSC	chr6	27866835	3'Flank	novel		0.14
HNSC	chr6	27867000	Missense_Mutation	novel	A177V	0.32
HNSC	chr6	27867342	Frame_Shift_Del	novel	*L60Sfs3**	0.07
HNSC	chr6	27867343	Frame_Shift_Del	novel	*A63Qfs7**	0.09
HNSC	chr6	27867096	Missense_Mutation	novel	A145D	0.16
HNSC	chr6	27867169	Missense_Mutation	novel	P121A	0.13
KIRP	chr6	27866879	In_Frame_Del	novel	P203_K217del	0.07
LIHC	chr6	27866968	Missense_Mutation	rs745570564	K188E	0.23
LIHC	chr6	27866937	Missense_Mutation	novel	P198Q	0.52
LIHC	chr6	27872318	5'Flank	rs749122167		0.15
LUAD	chr6	27867432	Missense_Mutation	NA	A33D	0.08
LUAD	chr6	27867116	Silent	novel	T138T	0.23
LUAD	chr6	27867360	Missense_Mutation	NA	R57L	0.2
LUAD	chr6	27867362	Silent	novel	E56E	0.07
LUAD	chr6	27866879	Missense_Mutation	NA	K217N	0.4
LUAD	chr6	27867399	Missense_Mutation	novel	S44L	0.07
LUAD	chr6	27867148	Missense_Mutation	novel	A128S	0.08
LUAD	chr6	27867444	Missense_Mutation	NA	A29G	0.08
LUAD	chr6	27867304	Missense_Mutation	novel	V76M	0.06
LUAD	chr6	27867334	Missense_Mutation	novel	K66E	0.41
LUSC	chr6	27871856	5'Flank	rs768591870		0.2
LUSC	chr6	27867024	Missense_Mutation	NA	K169M	0.58
LUSC	chr6	27871853	5'Flank	novel		0.47
LUSC	chr6	27871897	5'Flank	novel		0.18
LUSC	chr6	27866803	3'Flank	novel		0.24
LUSC	chr6	27867197	Missense_Mutation	novel	N111K	0.15
LUSC	chr6	27867392	Silent	NA	L46L	0.24
LUSC	chr6	27867193	Missense_Mutation	novel	K113E	0.34
LUSC	chr6	27867416	Silent	NA	A38A	0.58
LUSC	chr6	27872318	5'Flank	rs749122167		0.23
OV	chr6	27867563	5'Flank	novel		0.13
OV	chr6	27871886	5'Flank	novel		0.13
PAAD	chr6	27867056	In_Frame_Del	rs545007006	T155_K158del	0.12
PAAD	chr6	27867222	Missense_Mutation	novel	G103D	0.17
READ	chr6	27867042	Missense_Mutation	NA	A163E	0.46
READ	chr6	27867375	Missense_Mutation	rs780574435	A52V	0.31
READ	chr6	27867239	Silent	NA	V97V	0.14
READ	chr6	27866918	Missense_Mutation	NA	K204N	0.38
READ	chr6	27867348	Missense_Mutation	novel	S61Y	0.13
SARC	chr6	27867496	Missense_Mutation	novel	P12S	0.09
SKCM	chr6	27867275	Silent	novel	L85L	0.28
SKCM	chr6	27867233	Silent	NA	T99T	0.27
SKCM	chr6	27867337	Missense_Mutation	rs776773973	L65F	0.17
SKCM	chr6	27866876	Silent	NA	A218A	0.17
SKCM	chr6	27867005	Silent	NA	K175K	0.48
SKCM	chr6	27867125	Silent	novel	A135A	0.19
SKCM	chr6	27867098	In_Frame_Del	novel	P134_K144del	0.05
SKCM	chr6	27867263	Silent	rs372908864	S89S	0.74
SKCM	chr6	27867056	Silent	rs143393068	K158K	0.52
SKCM	chr6	27867513	Missense_Mutation	rs773069523	P6L	0.6
SKCM	chr6	27867045	Missense_Mutation	NA	P162L	0.29
SKCM	chr6	27867158	Silent	NA	K124K	0.26
SKCM	chr6	27867568	5'Flank	novel		0.19
SKCM	chr6	27867332	Silent	NA	K66K	0.39
SKCM	chr6	27867302	Silent	rs781695711	V76V	0.26
SKCM	chr6	27867122	Silent	novel	G136G	0.3
SKCM	chr6	27867123	Missense_Mutation	novel	G136E	0.3
SKCM	chr6	27867129	Missense_Mutation	NA	P134L	0.85
SKCM	chr6	27866970	Missense_Mutation	rs779719317	T187I	0.23
STAD	chr6	27866896	Nonsense_Mutation	NA	K212*	0.12
STAD	chr6	27866873	In_Frame_Del	novel	P198_K219del	0.27
STAD	chr6	27866869	Missense_Mutation	NA	A221T	0.24
STAD	chr6	27867308	Silent	NA	Y74Y	0.09
STAD	chr6	27867518	Silent	novel	T4T	0.17
STAD	chr6	27867227	Silent	novel	G101G	0.05
STAD	chr6	27867050	Missense_Mutation	novel	K160N	0.13
STAD	chr6	27867144	Missense_Mutation	NA	A129V	0.08
STAD	chr6	27867256	Missense_Mutation	novel	S92R	0.28
STAD	chr6	27867110	Silent	NA	K140K	0.23
STAD	chr6	27866835	3'Flank	novel		0.36
STAD	chr6	27866971	Missense_Mutation	NA	T187A	0.42
STAD	chr6	27867225	In_Frame_Del	novel	L96_T102del	0.14
STAD	chr6	27867561	5'Flank	novel		0.72
STAD	chr6	27866895	Missense_Mutation	NA	K212R	0.22
TGCT	chr6	27866928	Missense_Mutation	novel	A201V	0.21
UCEC	chr6	27867131	Silent	rs750300228	K133K	0.39
UCEC	chr6	27867475	Missense_Mutation	novel	P19S	0.48
UCEC	chr6	27866873	Silent	rs776382299	K219K	0.21
UCEC	chr6	27866994	Missense_Mutation	novel	A179V	0.44
UCEC	chr6	27866855	Missense_Mutation	rs769817801	K225N	0.12
UCEC	chr6	27871886	5'Flank	novel		0.1
UCEC	chr6	27867312	Missense_Mutation	NA	G73D	0.32
UCEC	chr6	27867287	Silent	novel	S81S	0.43
UCEC	chr6	27867086	Silent	NA	A148A	0.42
UCEC	chr6	27867026	Silent	novel	K168K	0.24
UCEC	chr6	27867502	Missense_Mutation	novel	A10S	0.37
UCEC	chr6	27867249	Missense_Mutation	NA	G94D	0.32
UCEC	chr6	27866961	Missense_Mutation	novel	P190H	0.28
UCEC	chr6	27867018	Missense_Mutation	rs748940475	A171V	0.16
UCEC	chr6	27867317	Silent	rs749604290	A71A	0.33
UCEC	chr6	27867224	Silent	NA	T102T	0.32
UCEC	chr6	27867031	Missense_Mutation	novel	V167I	0.06
UCEC	chr6	27866868	Missense_Mutation	rs748484962	A221V	0.57
UCEC	chr6	27871846	5'Flank	novel		0.16
UCEC	chr6	27867063	Missense_Mutation	novel	P156L	0.36
UCS	chr6	27867062	Silent	novel	P156P	0.14

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value

Survival Analysis

Cancer	P-value	Q-value
THYM	0.033	Kaplan-Meier Survival Analysis
KIRC	0.00077	Kaplan-Meier Survival Analysis
STAD	0.0039	Kaplan-Meier Survival Analysis
SARC	0.023	Kaplan-Meier Survival Analysis
MESO	0.00012	Kaplan-Meier Survival Analysis
ACC	0.00017	Kaplan-Meier Survival Analysis
UCS	0.016	Kaplan-Meier Survival Analysis
HNSC	0.028	Kaplan-Meier Survival Analysis
ESCA	0.0024	Kaplan-Meier Survival Analysis
PAAD	0.017	Kaplan-Meier Survival Analysis
CESC	0.00037	Kaplan-Meier Survival Analysis
READ	0.012	Kaplan-Meier Survival Analysis
LAML	0.042	Kaplan-Meier Survival Analysis
LIHC	0.012	Kaplan-Meier Survival Analysis
DLBC	0.042	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
CHOL	0.014	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000184357 (Gene tree)
Gene ID: 3009
Gene Symbol: HIST1H1B
Alias: H1.5|H1b|H1s-3|H1F5
Full Name: histone cluster 1 H1 family member b
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 790 bases
Position: chr6:27,866,792-27,867,581
Accession: 4719
RBP type: non-canonical RBP
Summary: Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000331442	HIST1H1B-201	681	-	ENSP00000330074	226 (aa)	-	P16401

Gene Model

Click here to download ENSG00000184357's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000184357	Lupus Erythematosus, Systemic	3.81881E-9	18204098

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000184357's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0000122	negative regulation of transcription by RNA polymerase II	22956909.	IMP	Process
GO:0000786	nucleosome	-	IEA	Component
GO:0000790	nuclear chromatin	19882353.22956909.	IDA	Component
GO:0003690	double-stranded DNA binding	21873635.	IBA	Function
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005515	protein binding	21873635.	IBA	Function
GO:0005515	protein binding	26496610.30021884.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	21383955.	IDA	Component
GO:0005720	nuclear heterochromatin	21873635.	IBA	Component
GO:0005720	nuclear heterochromatin	15911621.	IDA	Component
GO:0006325	chromatin organization	22956909.	IMP	Process
GO:0006334	nucleosome assembly	-	IEA	Process
GO:0006355	regulation of transcription, DNA-templated	21873635.	IBA	Process
GO:0016584	nucleosome positioning	21873635.	IBA	Process
GO:0030261	chromosome condensation	21873635.	IBA	Process
GO:0030307	positive regulation of cell growth	22956909.	IMP	Process
GO:0031490	chromatin DNA binding	15911621.22956909.	IMP	Function
GO:0031492	nucleosomal DNA binding	21873635.	IBA	Function
GO:0031936	negative regulation of chromatin silencing	21873635.	IBA	Process
GO:0042826	histone deacetylase binding	21873635.	IBA	Function
GO:0042826	histone deacetylase binding	22956909.	IPI	Function
GO:0045910	negative regulation of DNA recombination	21873635.	IBA	Process
GO:0050821	protein stabilization	22956909.	IMP	Process
GO:0051574	positive regulation of histone H3-K9 methylation	21873635.	IBA	Process
GO:0051574	positive regulation of histone H3-K9 methylation	22956909.	IMP	Process
GO:0071169	establishment of protein localization to chromatin	21873635.	IBA	Process
GO:0071169	establishment of protein localization to chromatin	22956909.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.