EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
21868628	MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas.	Science	2011 Oct 14	Mkinen N	doi: 10.1126/science.1208930
25964426	Clonally related uterine leiomyomas are common and display branched tumor evolution.	Hum Mol Genet	2015 Aug 1	Mehine M	doi: 10.1093/hmg/ddv177
22768200	MED12 alterations in both human benign and malignant uterine soft tissue tumors.	PLoS One	2012	P??rot G	doi: 10.1371/journal.pone.0040015
28183795	MED12 is recurrently mutated in Middle Eastern colorectal cancer.	Gut	2018 Apr	Siraj AK	doi: 10.1136/gutjnl-2016-313334
28634282	Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of MED12 and RBM10 as Novel Thyroid Cancer Genes Associated with Tumor Virulence.	Clin Cancer Res	2017 Oct 1	Ibrahimpasic T	doi: 10.1158/1078-0432.CCR-17-1183
29315289	MED12, TERT promoter and RBM15 mutations in primary and recurrent phyllodes tumours.	Br J Cancer	2018 Jan	Garcia-Dios DA	doi: 10.1038/bjc.2017.450
23178117	MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling.	Cell	2012 Nov 21	Huang S	doi: 10.1016/j.cell.2012.10.035.
24938407	MED12 overexpression is a frequent event in castration-resistant prostate cancer.	Endocr Relat Cancer	2014 Aug	Shaikhibrahim Z	doi: 10.1530/ERC-14-0171
26383637	Somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms.	Prostate	2016 Jan	Kmpjrvi K	doi: 10.1002/pros.23092
28055980	Immunohistochemical profiling of receptor tyrosine kinases, MED12, and TGF-βRII of surgically resected small cell lung cancer, and the potential of c-kit as a prognostic marker.	Oncotarget	2017 Jun 13	Yokouchi H	doi: 10.18632/oncotarget.14410.
29628309	JMJD6 Licenses ERα-Dependent Enhancer and Coding Gene Activation by Modulating the Recruitment of the CARM1/MED12 Co-activator Complex.	Mol Cell	2018 Apr 19	Gao WW	doi: 10.1016/j.molcel.2018.03.006

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chrX	71132463	Missense_Mutation	novel	A1447D	0.09
BLCA	chrX	71121014	Missense_Mutation	novel	Q199H	0.75
BLCA	chrX	71137306	Missense_Mutation	novel	S1891A	0.48
BLCA	chrX	71120131	Missense_Mutation	NA	E172Q	0.36
BLCA	chrX	71121682	Missense_Mutation	novel	Q323E	0.36
BLCA	chrX	71129390	Missense_Mutation	NA	G1218R	0.23
BLCA	chrX	71125371	Missense_Mutation	NA	E749D	0.64
BLCA	chrX	71137184	Splice_Region	novel		0.23
BLCA	chrX	71120038	Missense_Mutation	NA	E141Q	0.54
BLCA	chrX	71130102	Missense_Mutation	novel	L1312S	0.83
BLCA	chrX	71123111	Missense_Mutation	novel	D501G	0.48
BLCA	chrX	71118851	Missense_Mutation	rs769202858	E33K	0.33
BLCA	chrX	71119403	In_Frame_Del	novel	G44_F45del	0.5
BLCA	chrX	71118851	Missense_Mutation	rs769202858	E33K	0.43
BLCA	chrX	71118833	Missense_Mutation	NA	Q27E	0.38
BLCA	chrX	71121065	Silent	NA	G216G	0.35
BLCA	chrX	71118845	Missense_Mutation	novel	Q31E	0.18
BLCA	chrX	71121678	Silent	novel	S321S	0.28
BLCA	chrX	71121667	Missense_Mutation	novel	H318D	0.8
BLCA	chrX	71130092	Missense_Mutation	novel	D1309N	0.46
BLCA	chrX	71127094	Silent	rs766716404	L937L	0.93
BLCA	chrX	71126470	Missense_Mutation	NA	D891N	0.09
BLCA	chrX	71128116	Missense_Mutation	novel	D1069Y	0.2
BLCA	chrX	71135182	Missense_Mutation	NA	E1652K	0.91
BLCA	chrX	71136617	Missense_Mutation	novel	K1788E	0.75
BLCA	chrX	71137560	Splice_Region	novel	Q1917Q	0.56
BLCA	chrX	71119839	Missense_Mutation	novel	L120V	0.77
BRCA	chrX	71121118	Missense_Mutation	NA	D234V	0.48
BRCA	chrX	71128603	Missense_Mutation	novel	S1120R	0.08
BRCA	chrX	71137242	Silent	NA	P1869P	0.34
BRCA	chrX	71136981	Frame_Shift_Del	novel	*Q1836Lfs57**	0.34
BRCA	chrX	71132440	Silent	NA	V1439V	0.17
BRCA	chrX	71132189	Missense_Mutation	NA	K1412N	0.14
BRCA	chrX	71136454	Silent	NA	R1733R	0.11
BRCA	chrX	71132918	Nonsense_Mutation	NA	E1497*	0.27
BRCA	chrX	71136433	Frame_Shift_Ins	NA	*L1730Tfs2**	0.26
BRCA	chrX	71132535	Missense_Mutation	novel	K1471M	0.09
BRCA	chrX	71142312	3'UTR	novel		0.27
BRCA	chrX	71125410	Silent	NA	K762K	0.46
BRCA	chrX	71121075	Missense_Mutation	NA	G220R	0.28
BRCA	chrX	71121682	Nonsense_Mutation	novel	Q323*	0.03
BRCA	chrX	71125071	Missense_Mutation	NA	K717N	0.19
BRCA	chrX	71136393	Missense_Mutation	rs374390933	R1713Q	0.32
BRCA	chrX	71121369	Nonsense_Mutation	novel	E260*	0.04
BRCA	chrX	71136402	Missense_Mutation	NA	R1716Q	0.45
BRCA	chrX	71141346	Missense_Mutation	novel	Q2128H	0.2
BRCA	chrX	71128316	Missense_Mutation	novel	L1077Q	0.1
BRCA	chrX	71130196	In_Frame_Ins	novel	I1344dup	0.34
BRCA	chrX	71137795	Missense_Mutation	novel	P1966A	0.08
BRCA	chrX	71141950	Missense_Mutation	NA	Q2159R	0.44
BRCA	chrX	71137773	Silent	rs370235478	G1958G	0.17
BRCA	chrX	71126112	Missense_Mutation	NA	F833L	0.25
BRCA	chrX	71120987	Silent	NA	I190I	0.17
BRCA	chrX	71119386	In_Frame_Del	novel	L39_P49del	0.13
BRCA	chrX	71135164	Nonsense_Mutation	NA	R1646*	0.42
BRCA	chrX	71132094	Missense_Mutation	NA	N1381Y	0.12
BRCA	chrX	71120139	Missense_Mutation	NA	K174N	0.23
BRCA	chrX	71122770	Missense_Mutation	NA	E461K	0.16
BRCA	chrX	71127020	Missense_Mutation	NA	D913Y	0.47
BRCA	chrX	71137824	Silent	NA	S1975S	0.22
BRCA	chrX	71141964	Missense_Mutation	NA	N2164D	0.32
BRCA	chrX	71129739	Missense_Mutation	NA	E1251K	0.14
BRCA	chrX	71132454	Nonsense_Mutation	novel	L1444*	0.06
CESC	chrX	71118821	Missense_Mutation	NA	D23Y	0.48
CESC	chrX	71142156	Splice_Site	novel	X2164_splice	0.41
CESC	chrX	71124275	Nonsense_Mutation	NA	R621*	0.31
CESC	chrX	71137219	Missense_Mutation	rs200279192	R1862C	0.3
CESC	chrX	71125415	Missense_Mutation	NA	R764Q	0.41
CESC	chrX	71126338	Splice_Region	NA		0.21
CESC	chrX	71121637	Missense_Mutation	NA	Q308E	0.21
CESC	chrX	71122303	Missense_Mutation	NA	S402Y	0.24
CESC	chrX	71128414	Missense_Mutation	novel	F1110L	0.18
CESC	chrX	71122607	Missense_Mutation	NA	G450R	0.12
CESC	chrX	71119807	Missense_Mutation	NA	S109F	0.26
CESC	chrX	71122550	Missense_Mutation	novel	R431W	0.43
CESC	chrX	71125476	Frame_Shift_Ins	novel	*G786Rfs6**	0.38
CESC	chrX	71134412	Missense_Mutation	novel	A1558V	0.3
CESC	chrX	71137267	Missense_Mutation	novel	L1878M	0.33
CESC	chrX	71119683	Splice_Region	novel		0.57
CESC	chrX	71131572	Missense_Mutation	NA	R1357H	0.32
CESC	chrX	71134755	Silent	novel	I1590I	0.09
CESC	chrX	71129147	Missense_Mutation	novel	R1170Q	0.56
CESC	chrX	71123179	Missense_Mutation	novel	V524M	0.52
CESC	chrX	71121718	Nonsense_Mutation	NA	Q335*	0.24
CESC	chrX	71118821	Missense_Mutation	NA	D23Y	0.26
CESC	chrX	71119683	Splice_Region	novel		0.49
CESC	chrX	71128655	Missense_Mutation	NA	R1138W	0.22
CESC	chrX	71121723	Silent	NA	P336P	0.25
COAD	chrX	71137563	Silent	NA	S1918S	0.56
COAD	chrX	71121387	Missense_Mutation	NA	R266C	0.33
COAD	chrX	71126059	Nonsense_Mutation	NA	R816*	0.17
COAD	chrX	71126063	Missense_Mutation	rs749801457	R817H	0.23
COAD	chrX	71129814	Missense_Mutation	NA	D1276N	0.49
COAD	chrX	71141238	Silent	novel	Q2092Q	0.11
COAD	chrX	71121744	Silent	NA	S343S	0.77
COAD	chrX	71125449	Silent	NA	T775T	0.16
COAD	chrX	71141271	Silent	NA	Q2103Q	0.58
COAD	chrX	71134843	Silent	NA	L1620L	0.38
COAD	chrX	71135163	Silent	NA	T1645T	0.26
COAD	chrX	71132936	Missense_Mutation	NA	L1503I	0.07
COAD	chrX	71118853	Missense_Mutation	NA	E33D	0.32
COAD	chrX	71136312	Missense_Mutation	NA	S1686L	0.07
COAD	chrX	71121136	Missense_Mutation	novel	A240V	0.09
COAD	chrX	71124334	Silent	NA	P640P	0.36
COAD	chrX	71127074	Missense_Mutation	NA	R931G	0.79
COAD	chrX	71140702	Missense_Mutation	rs762612521	V2038I	0.75
COAD	chrX	71131572	Missense_Mutation	NA	R1357H	0.28
COAD	chrX	71135161	Missense_Mutation	novel	T1645A	0.12
COAD	chrX	71130059	Missense_Mutation	NA	K1298E	0.47
COAD	chrX	71127036	Missense_Mutation	NA	Y918C	0.63
COAD	chrX	71125487	Missense_Mutation	NA	A788E	0.29
COAD	chrX	71118853	Missense_Mutation	NA	E33D	0.89
COAD	chrX	71128649	Missense_Mutation	NA	I1136V	0.85
COAD	chrX	71141247	In_Frame_Ins	rs777164189	Q2115dup	0.76
COAD	chrX	71123617	Silent	NA	A547A	0.31
COAD	chrX	71132481	Missense_Mutation	NA	K1453T	0.18
COAD	chrX	71142203	Missense_Mutation	novel	I2173M	0.25
COAD	chrX	71118592	5'Flank	novel		0.3
COAD	chrX	71140791	Silent	rs375793297	Q2067Q	0.19
COAD	chrX	71130173	Frame_Shift_Del	NA	*E1337Kfs8**	0.26
COAD	chrX	71123144	Nonsense_Mutation	novel	S513_C514ins*	0.03
COAD	chrX	71131570	Missense_Mutation	NA	M1356I	0.31
COAD	chrX	71121436	Missense_Mutation	novel	R282Q	0.05
COAD	chrX	71132516	Missense_Mutation	NA	R1465C	0.59
COAD	chrX	71127074	Missense_Mutation	novel	R931W	0.12
DLBC	chrX	71122270	Missense_Mutation	novel	G391V	0.34
DLBC	chrX	71132517	Missense_Mutation	novel	R1465H	0.11
ESCA	chrX	71120083	Missense_Mutation	novel	A156S	0.19
ESCA	chrX	71122524	Missense_Mutation	novel	R422L	0.06
GBM	chrX	71121645	Missense_Mutation	novel	D310E	0.14
GBM	chrX	71137913	Missense_Mutation	novel	T2005N	0.31
GBM	chrX	71121580	Nonsense_Mutation	NA	Q289*	0.21
GBM	chrX	71121344	Missense_Mutation	novel	R251S	0.16
GBM	chrX	71122787	Frame_Shift_Ins	novel	*S467Efs3**	0.04
GBM	chrX	71122311	Missense_Mutation	novel	P405S	0.26
GBM	chrX	71127075	Missense_Mutation	novel	R931Q	0.07
GBM	chrX	71127980	Silent	rs753751305	I1023I	0.61
GBM	chrX	71128645	Silent	novel	I1134I	0.12
GBM	chrX	71129790	Missense_Mutation	novel	I1268F	0.35
GBM	chrX	71122562	Missense_Mutation	NA	V435L	0.5
GBM	chrX	71140855	Missense_Mutation	NA	R2089W	0.87
GBM	chrX	71132100	Missense_Mutation	NA	A1383T	0.45
GBM	chrX	71118793	Silent	novel	P13P	0.56
GBM	chrX	71119392	Missense_Mutation	novel	N40T	1
GBM	chrX	71119877	Missense_Mutation	novel	K132N	0.26
GBM	chrX	71120080	Missense_Mutation	novel	R155W	0.08
GBM	chrX	71127346	Missense_Mutation	novel	V954I	0.77
GBM	chrX	71121346	Missense_Mutation	novel	H252R	0.8
GBM	chrX	71125098	Silent	rs763782632	Y726Y	0.2
HNSC	chrX	71142245	3'UTR	novel		0.29
HNSC	chrX	71127368	Missense_Mutation	rs766598254	R961Q	0.26
HNSC	chrX	71129343	Missense_Mutation	NA	S1202F	0.49
HNSC	chrX	71118766	Missense_Mutation	novel	F4L	0.67
HNSC	chrX	71126993	Missense_Mutation	novel	E904Q	0.07
HNSC	chrX	71131578	Missense_Mutation	novel	S1359Y	0.27
HNSC	chrX	71129736	Missense_Mutation	novel	P1250S	0.36
HNSC	chrX	71129737	Missense_Mutation	novel	P1250L	0.36
HNSC	chrX	71121039	Missense_Mutation	novel	G208W	0.56
HNSC	chrX	71136913	Missense_Mutation	novel	Y1812C	0.24
HNSC	chrX	71128010	Silent	novel	T1033T	0.1
HNSC	chrX	71137626	Missense_Mutation	NA	Q1939H	0.1
HNSC	chrX	71122343	Silent	novel	Q415Q	0.26
HNSC	chrX	71118800	Missense_Mutation	novel	R16G	0.11
HNSC	chrX	71127892	Splice_Site	novel	X994_splice	0.32
HNSC	chrX	71125427	Missense_Mutation	novel	R768L	0.39
HNSC	chrX	71133175	Missense_Mutation	novel	Q1527R	0.63
HNSC	chrX	71119879	Splice_Site	novel	X132_splice	0.31
HNSC	chrX	71130145	Silent	novel	Y1326Y	0.13
HNSC	chrX	71136453	Missense_Mutation	rs754537871	R1733Q	0.71
KIRC	chrX	71140719	Silent	NA	R2043R	0.15
KIRC	chrX	71122338	Missense_Mutation	NA	T414A	0.28
KIRC	chrX	71127102	Missense_Mutation	novel	N940I	0.18
KIRC	chrX	71128401	Missense_Mutation	novel	N1105K	0.02
KIRC	chrX	71121331	Missense_Mutation	NA	G247V	0.27
KIRP	chrX	71129348	Missense_Mutation	NA	D1204Y	0.23
KIRP	chrX	71135194	Missense_Mutation	novel	S1656A	0.39
KIRP	chrX	71130188	Missense_Mutation	rs777250096	R1341W	0.49
LAML	chrX	71136318	Nonsense_Mutation	novel	W1688*	0.97
LAML	chrX	71126383	Missense_Mutation	novel	G862S	0.06
LAML	chrX	71127367	Missense_Mutation	rs80338758	R961W	0.52
LAML	chrX	71123632	Silent	novel	S552S	0.2
LAML	chrX	71122245	Missense_Mutation	novel	L383V	0.12
LGG	chrX	71137211	Missense_Mutation	rs763700798	R1859H	0.23
LGG	chrX	71133136	Nonsense_Mutation	novel	W1514*	0.4
LGG	chrX	71131558	Missense_Mutation	NA	D1352E	0.12
LGG	chrX	71118717	Missense_Mutation	novel		0.43
LGG	chrX	71126087	Missense_Mutation	NA	T825N	0.18
LGG	chrX	71121407	Missense_Mutation	NA	L272F	0.1
LGG	chrX	71120097	Silent	novel	I160I	0.09
LGG	chrX	71124182	Missense_Mutation	novel	R590W	0.08
LGG	chrX	71127373	Missense_Mutation	novel	D963N	0.45
LGG	chrX	71129415	Missense_Mutation	novel	A1226D	0.58
LGG	chrX	71132513	Missense_Mutation	novel	E1464K	0.5
LGG	chrX	71126449	Missense_Mutation	NA	L884V	0.23
LGG	chrX	71119404	Missense_Mutation	rs199469672	G44A	0.28
LIHC	chrX	71132398	Silent	novel	V1425V	0.28
LIHC	chrX	71120988	Missense_Mutation	novel	T191S	0.04
LIHC	chrX	71134792	Missense_Mutation	novel	Q1603K	0.31
LIHC	chrX	71129424	Missense_Mutation	NA	V1229E	0.84
LIHC	chrX	71127057	Missense_Mutation	novel	C925F	0.67
LIHC	chrX	71118782	Missense_Mutation	NA	E10Q	0.74
LIHC	chrX	71118629	5'Flank	novel		0.92
LUAD	chrX	71121708	Silent	NA	T331T	0.55
LUAD	chrX	71125429	Missense_Mutation	rs755014778	H769N	0.28
LUAD	chrX	71128600	Splice_Region	NA	V1119V	0.35
LUAD	chrX	71129340	Missense_Mutation	novel	S1201Y	0.15
LUAD	chrX	71121055	Missense_Mutation	novel	G213V	0.29
LUAD	chrX	71121056	Silent	novel	G213G	0.29
LUAD	chrX	71126050	Nonsense_Mutation	NA	Q813*	0.79
LUAD	chrX	71127075	Missense_Mutation	novel	R931P	0.69
LUAD	chrX	71132087	Silent	NA	L1378L	0.37
LUAD	chrX	71132416	Silent	NA	L1431L	0.38
LUAD	chrX	71119752	Missense_Mutation	novel	R91C	0.6
LUAD	chrX	71119753	Missense_Mutation	novel	R91L	0.63
LUAD	chrX	71136470	Silent	novel	L1739L	0.83
LUAD	chrX	71125143	Silent	novel	P741P	0.18
LUAD	chrX	71141880	Splice_Region	novel		0.46
LUAD	chrX	71120146	Frame_Shift_Ins	novel	*H179Dfs42**	0.62
LUAD	chrX	71123178	Missense_Mutation	NA	M523I	0.66
LUAD	chrX	71126057	Missense_Mutation	NA	R815L	0.55
LUAD	chrX	71125427	Missense_Mutation	novel	R768P	0.4
LUAD	chrX	71121080	Silent	NA	P221P	0.1
LUAD	chrX	71135120	Missense_Mutation	novel	S1631I	0.92
LUAD	chrX	71126069	Missense_Mutation	novel	R819L	0.07
LUAD	chrX	71132507	Missense_Mutation	NA	R1462C	0.27
LUAD	chrX	71125415	Missense_Mutation	NA	R764Q	0.26
LUAD	chrX	71121152	Splice_Region	NA	Q245Q	0.24
LUAD	chrX	71137747	Missense_Mutation	NA	H1950Y	0.1
LUAD	chrX	71127894	Missense_Mutation	rs771092011	D995N	0.39
LUAD	chrX	71123102	Nonsense_Mutation	novel	S498*	0.08
LUAD	chrX	71137880	Missense_Mutation	novel	R1994L	0.13
LUAD	chrX	71132443	Missense_Mutation	novel	Q1440H	0.31
LUAD	chrX	71121096	Nonsense_Mutation	novel	E227*	0.4
LUAD	chrX	71125710	Missense_Mutation	NA	L807V	0.18
LUAD	chrX	71121777	Missense_Mutation	novel	Q354H	0.11
LUAD	chrX	71123140	Missense_Mutation	NA	A511S	0.15
LUAD	chrX	71136955	Missense_Mutation	NA	P1826L	0.12
LUAD	chrX	71123626	Missense_Mutation	NA	K550N	0.44
LUAD	chrX	71137943	Missense_Mutation	novel	R2015M	0.23
LUAD	chrX	71137944	Splice_Site	novel	X2015_splice	0.23
LUAD	chrX	71123211	Silent	NA	A534A	0.21
LUAD	chrX	71140663	Missense_Mutation	novel	P2025T	0.15
LUAD	chrX	71136417	Missense_Mutation	novel	Q1721L	0.35
LUAD	chrX	71127421	Missense_Mutation	NA	Y979H	0.05
LUAD	chrX	71121781	Missense_Mutation	NA	R356W	0.43
LUAD	chrX	71136569	Missense_Mutation	novel	P1772T	0.21
LUAD	chrX	71128367	Missense_Mutation	NA	G1094E	0.2
LUAD	chrX	71127392	Missense_Mutation	novel	R969P	0.1
LUAD	chrX	71127388	Missense_Mutation	novel	E968Q	0.22
LUAD	chrX	71128321	Missense_Mutation	novel	A1079S	0.17
LUAD	chrX	71134747	Missense_Mutation	rs767396596	V1588M	0.21
LUAD	chrX	71128391	Missense_Mutation	novel	S1102Y	0.27
LUAD	chrX	71121096	Missense_Mutation	NA	E227Q	0.27
LUAD	chrX	71129340	Missense_Mutation	novel	S1201Y	0.08
LUSC	chrX	71137865	Missense_Mutation	novel	R1989H	0.27
LUSC	chrX	71121348	Missense_Mutation	novel	E253Q	0.28
LUSC	chrX	71119803	Silent	novel	R108R	0.57
LUSC	chrX	71122304	Silent	novel	S402S	0.51
LUSC	chrX	71128036	Missense_Mutation	NA	S1042I	0.29
LUSC	chrX	71120170	Missense_Mutation	novel	E185K	0.05
LUSC	chrX	71137364	Missense_Mutation	novel	R1910H	0.19
LUSC	chrX	71137835	Missense_Mutation	novel	S1979C	0.19
LUSC	chrX	71132176	Missense_Mutation	novel	P1408H	0.32
LUSC	chrX	71121055	Missense_Mutation	novel	G213V	0.19
LUSC	chrX	71128648	Silent	novel	L1135L	0.17
LUSC	chrX	71132072	Splice_Site	NA	X1374_splice	0.23
LUSC	chrX	71132073	Nonsense_Mutation	NA	E1374*	0.22
LUSC	chrX	71129408	Missense_Mutation	NA	L1224V	0.36
LUSC	chrX	71136393	Missense_Mutation	novel	R1713P	0.09
LUSC	chrX	71126386	Missense_Mutation	novel	M863L	0.37
LUSC	chrX	71137812	Silent	novel	Q1971Q	0.63
LUSC	chrX	71130083	Missense_Mutation	novel	D1306N	0.59
LUSC	chrX	71123615	Missense_Mutation	NA	A547P	0.94
LUSC	chrX	71130141	Missense_Mutation	novel	C1325F	0.52
LUSC	chrX	71124973	Splice_Region	novel		0.23
LUSC	chrX	71124785	Missense_Mutation	NA	M666V	0.7
LUSC	chrX	71125366	Missense_Mutation	novel	H748N	0.16
LUSC	chrX	71131604	Missense_Mutation	NA	K1368Q	0.21
LUSC	chrX	71119779	Missense_Mutation	novel	D100Y	0.09
LUSC	chrX	71131611	Missense_Mutation	novel	T1370N	0.29
LUSC	chrX	71125687	Missense_Mutation	novel	L799R	0.19
LUSC	chrX	71125688	Silent	novel	L799L	0.2
LUSC	chrX	71122756	Missense_Mutation	novel	V456A	0.2
MESO	chrX	71130144	Missense_Mutation	novel	Y1326S	0.67
OV	chrX	71127345	Silent	novel	G953G	0.12
OV	chrX	71136455	Missense_Mutation	novel	P1734S	0.18
OV	chrX	71128019	Silent	novel	Y1036Y	0.1
OV	chrX	71136550	Frame_Shift_Ins	novel	*K1768Qfs3**	0.17
OV	chrX	71142379	3'UTR	novel		0.52
OV	chrX	71132953	Missense_Mutation	NA	H1508Q	0.23
OV	chrX	71142301	3'UTR	novel		0.1
OV	chrX	71128630	Silent	novel	A1129A	0.06
OV	chrX	71140714	Missense_Mutation	rs755577187	V2042I	0.45
OV	chrX	71122329	Missense_Mutation	novel	S411G	0.45
OV	chrX	71133127	Missense_Mutation	novel	V1511G	0.05
OV	chrX	71141924	Frame_Shift_Ins	novel	*T2151Qfs69**	0.07
PAAD	chrX	71128372	Missense_Mutation	novel	L1096I	0.26
PCPG	chrX	71130151	Missense_Mutation	novel	H1328Q	0.57
PRAD	chrX	71129408	Missense_Mutation	NA	L1224F	0.3
PRAD	chrX	71121770	Missense_Mutation	novel	C352F	0.1
PRAD	chrX	71129406	Missense_Mutation	NA	V1223G	0.52
PRAD	chrX	71129405	Missense_Mutation	NA	V1223L	0.43
PRAD	chrX	71128673	Missense_Mutation	NA	E1144Q	0.58
PRAD	chrX	71129408	Missense_Mutation	NA	L1224F	0.19
PRAD	chrX	71129405	Missense_Mutation	NA	V1223L	0.86
PRAD	chrX	71129408	Missense_Mutation	NA	L1224F	0.09
READ	chrX	71122753	Missense_Mutation	rs760696164	R455Q	0.57
READ	chrX	71119862	Silent	rs202125318	T127T	0.18
READ	chrX	71121105	Missense_Mutation	NA	I230V	0.93
READ	chrX	71118852	Missense_Mutation	NA	E33G	0.75
READ	chrX	71140855	Missense_Mutation	NA	R2089W	0.3
READ	chrX	71120057	Missense_Mutation	NA	A147G	0.42
READ	chrX	71129159	Missense_Mutation	NA	R1174H	0.52
SARC	chrX	71119404	Missense_Mutation	rs199469672	G44D	0.76
SARC	chrX	71130174	Missense_Mutation	novel	G1336V	0.11
SARC	chrX	71121607	Missense_Mutation	novel	A298S	0.12
SARC	chrX	71132878	Silent	novel	S1483S	0.15
SKCM	chrX	71120025	Silent	novel	F136F	0.14
SKCM	chrX	71132107	Missense_Mutation	rs771349148	A1385V	0.3
SKCM	chrX	71132405	Missense_Mutation	NA	V1428M	0.31
SKCM	chrX	71121107	Silent	novel	I230I	0.17
SKCM	chrX	71119807	Missense_Mutation	NA	S109F	0.48
SKCM	chrX	71123686	Silent	novel	L570L	1
SKCM	chrX	71124804	Missense_Mutation	novel	S672F	0.93
SKCM	chrX	71123647	Silent	novel	S557S	1
SKCM	chrX	71123100	Silent	NA	S497S	0.57
SKCM	chrX	71136569	Missense_Mutation	NA	P1772S	0.63
SKCM	chrX	71121065	Silent	NA	G216G	0.3
SKCM	chrX	71137830	Silent	NA	H1977H	0.91
SKCM	chrX	71132197	Missense_Mutation	novel	P1415L	0.49
SKCM	chrX	71140731	Silent	novel	I2047I	0.25
SKCM	chrX	71122543	Silent	novel	I428I	0.75
SKCM	chrX	71121748	Missense_Mutation	rs761157306	P345S	0.8
SKCM	chrX	71122532	Missense_Mutation	NA	E425K	0.09
SKCM	chrX	71126985	Missense_Mutation	NA	S901N	0.88
SKCM	chrX	71136910	Missense_Mutation	NA	P1811L	0.17
SKCM	chrX	71124332	Missense_Mutation	NA	P640S	0.43
SKCM	chrX	71121667	Missense_Mutation	novel	H318Y	0.62
SKCM	chrX	71130152	Nonsense_Mutation	NA	R1329*	0.24
SKCM	chrX	71136472	Silent	NA	L1739L	0.77
SKCM	chrX	71123099	Missense_Mutation	NA	S497F	0.25
SKCM	chrX	71142230	3'UTR	rs769990908		0.19
SKCM	chrX	71136492	Missense_Mutation	novel	P1746Q	0.57
SKCM	chrX	71123712	Missense_Mutation	NA	P579L	0.33
SKCM	chrX	71137774	Missense_Mutation	NA	P1959S	0.38
SKCM	chrX	71128651	Silent	rs756127182	I1136I	0.17
SKCM	chrX	71127380	Missense_Mutation	novel	S965F	0.35
SKCM	chrX	71123669	Missense_Mutation	novel	I565L	0.14
SKCM	chrX	71129807	Silent	novel	A1273A	0.28
SKCM	chrX	71137736	Missense_Mutation	novel	P1946L	0.25
SKCM	chrX	71136900	Missense_Mutation	rs372271659	R1808W	0.56
SKCM	chrX	71118769	Silent	NA	G5G	0.65
STAD	chrX	71124836	Missense_Mutation	NA	D683H	0.15
STAD	chrX	71129408	Missense_Mutation	NA	L1224F	0.87
STAD	chrX	71126384	Missense_Mutation	novel	G862D	0.71
STAD	chrX	71137226	Missense_Mutation	NA	P1864Q	0.09
STAD	chrX	71136560	Missense_Mutation	NA	T1769P	0.3
STAD	chrX	71124160	Splice_Region	rs773240125	T582T	0.25
STAD	chrX	71121756	Silent	NA	S347S	0.8
STAD	chrX	71136420	Missense_Mutation	NA	R1722Q	0.56
STAD	chrX	71127368	Missense_Mutation	rs766598254	R961Q	0.33
STAD	chrX	71121120	Missense_Mutation	NA	Y235H	0.7
STAD	chrX	71122582	Silent	rs371928861	F441F	0.25
STAD	chrX	71128624	Silent	NA	S1127S	0.39
STAD	chrX	71129839	Missense_Mutation	NA	R1284H	0.25
STAD	chrX	71121391	Missense_Mutation	NA	P267L	0.11
STAD	chrX	71121387	Missense_Mutation	NA	R266C	0.27
STAD	chrX	71141928	Missense_Mutation	NA	A2152T	0.18
STAD	chrX	71121599	Missense_Mutation	novel	R295H	0.16
STAD	chrX	71137332	Silent	novel	R1899R	0.11
STAD	chrX	71129774	Silent	NA	R1262R	0.23
STAD	chrX	71128309	Missense_Mutation	NA	A1075T	0.35
STAD	chrX	71136460	Silent	rs747836622	R1735R	0.17
UCEC	chrX	71128655	Missense_Mutation	NA	R1138G	0.5
UCEC	chrX	71128348	Silent	NA	L1088L	0.15
UCEC	chrX	71126440	Nonsense_Mutation	NA	E881*	0.4
UCEC	chrX	71136893	Silent	NA	G1805G	0.05
UCEC	chrX	71125698	Missense_Mutation	novel	D803Y	0.04
UCEC	chrX	71128066	Missense_Mutation	NA	S1052I	0.38
UCEC	chrX	71137914	Silent	NA	T2005T	0.27
UCEC	chrX	71118821	Missense_Mutation	NA	D23Y	0.47
UCEC	chrX	71121152	Missense_Mutation	novel	Q245H	0.11
UCEC	chrX	71121575	Missense_Mutation	novel	F287C	0.38
UCEC	chrX	71132190	Missense_Mutation	novel	T1413A	0.09
UCEC	chrX	71137267	Silent	novel	L1878L	0.31
UCEC	chrX	71134404	Silent	rs375001801	T1555T	0.46
UCEC	chrX	71119718	Missense_Mutation	NA	E79D	0.31
UCEC	chrX	71119827	Missense_Mutation	NA	W116R	0.35
UCEC	chrX	71124841	Missense_Mutation	NA	F684L	0.33
UCEC	chrX	71123171	Missense_Mutation	NA	R521H	0.25
UCEC	chrX	71123174	Missense_Mutation	novel	A522D	0.46
UCEC	chrX	71124829	Missense_Mutation	novel	E680D	0.08
UCEC	chrX	71125109	Missense_Mutation	novel	R730Q	0.4
UCEC	chrX	71128428	Silent	novel	L1114L	0.07
UCEC	chrX	71136878	Splice_Site	novel	X1801_splice	0.5
UCEC	chrX	71137817	Missense_Mutation	novel	Y1973C	0.19
UCEC	chrX	71142236	3'UTR	novel		0.4
UCEC	chrX	71137362	Silent	novel	Q1909Q	0.27
UCEC	chrX	71132114	Silent	rs776947543	I1387I	0.73
UCEC	chrX	71141228	Splice_Site	novel	X2093_splice	0.35
UCEC	chrX	71130117	Missense_Mutation	NA	A1317V	0.32
UCEC	chrX	71123164	Missense_Mutation	NA	R519W	0.46
UCEC	chrX	71124841	Silent	NA	F684F	0.42
UCEC	chrX	71124193	Missense_Mutation	novel	F593L	0.55
UCEC	chrX	71127098	Missense_Mutation	novel	L939I	0.4
UCEC	chrX	71129207	Missense_Mutation	novel	S1190Y	0.36
UCEC	chrX	71140736	Missense_Mutation	novel	P2049H	0.11
UCEC	chrX	71141305	Nonsense_Mutation	novel	Q2115*	0.39
UCEC	chrX	71135202	Silent	rs376179450	I1658I	0.19
UCEC	chrX	71120031	Missense_Mutation	novel	K138N	0.22
UCEC	chrX	71122599	Missense_Mutation	novel	A447V	0.4
UCEC	chrX	71136507	Missense_Mutation	rs748064846	P1751L	0.55
UCEC	chrX	71128416	Missense_Mutation	novel	F1110L	0.18
UCEC	chrX	71119752	Missense_Mutation	novel	R91C	0.07
UCEC	chrX	71126987	Missense_Mutation	NA	V902I	0.22
UCEC	chrX	71127996	Missense_Mutation	NA	P1029S	0.12
UCEC	chrX	71132508	Missense_Mutation	NA	R1462H	0.53
UCEC	chrX	71120127	Silent	NA	I170I	0.14
UCEC	chrX	71125068	Missense_Mutation	NA	E716D	0.12
UCEC	chrX	71129811	Missense_Mutation	NA	L1275M	0.33
UCEC	chrX	71137329	Silent	NA	Y1898Y	0.2
UCEC	chrX	71140717	Missense_Mutation	novel	R2043C	0.09
UCEC	chrX	71119478	Splice_Site	novel	X68_splice	0.35
UCEC	chrX	71134747	Missense_Mutation	rs767396596	V1588M	0.3
UCEC	chrX	71119700	In_Frame_Del	novel	S74_R82del	0.08
UCEC	chrX	71128030	Missense_Mutation	novel	G1040V	0.21
UCEC	chrX	71129374	Silent	novel	Q1212Q	0.18
UCEC	chrX	71133201	Missense_Mutation	novel	R1536W	0.11
UCEC	chrX	71135195	Missense_Mutation	novel	S1656Y	0.16
UCEC	chrX	71137003	Missense_Mutation	novel	Y1842C	0.17
UCEC	chrX	71137780	Missense_Mutation	novel	G1961S	0.1
UCEC	chrX	71134791	Silent	rs755218771	S1602S	0.49
UCEC	chrX	71141950	Missense_Mutation	novel	Q2159P	0.5
UCEC	chrX	71126150	Missense_Mutation	novel	A846V	0.06
UCEC	chrX	71142174	Splice_Site	novel	X2164_splice	0.32
UCEC	chrX	71121008	Silent	NA	Q197Q	0.31
UCEC	chrX	71122337	Silent	NA	F413F	0.42
UCEC	chrX	71126077	Missense_Mutation	NA	A822T	0.14
UCEC	chrX	71127124	Silent	NA	V947V	0.4
UCEC	chrX	71128354	Missense_Mutation	NA	A1090T	0.44
UCEC	chrX	71129187	Silent	rs756037504	P1183P	0.41
UCEC	chrX	71129688	Missense_Mutation	NA	E1234K	0.14
UCEC	chrX	71131559	Missense_Mutation	NA	Q1353K	0.38
UCEC	chrX	71137632	Silent	NA	S1941S	0.44
UCEC	chrX	71126993	Missense_Mutation	NA	E904K	0.38
UCEC	chrX	71125060	Missense_Mutation	novel	P714S	0.24
UCEC	chrX	71119857	Missense_Mutation	novel	L126I	0.38
UCEC	chrX	71121764	Missense_Mutation	novel	L350R	0.4
UCEC	chrX	71124338	Missense_Mutation	NA	D642N	0.39
UCEC	chrX	71126039	Missense_Mutation	novel	G809E	0.23
UCEC	chrX	71129411	Missense_Mutation	novel	K1225E	0.1
UCEC	chrX	71136294	Missense_Mutation	novel	S1680Y	0.31
UCEC	chrX	71136940	Missense_Mutation	novel	L1821P	0.4
UCEC	chrX	71142325	3'UTR	novel		0.29
UCEC	chrX	71123171	Missense_Mutation	NA	R521H	0.21
UCEC	chrX	71122297	Missense_Mutation	novel	A400V	0.29
UCEC	chrX	71124332	Missense_Mutation	NA	P640S	0.32
UCEC	chrX	71126056	Missense_Mutation	NA	R815W	0.5
UCEC	chrX	71119861	Missense_Mutation	rs775072642	T127M	0.31
UCEC	chrX	71124263	Missense_Mutation	rs765417606	T617A	0.2
UCEC	chrX	71121029	Nonsense_Mutation	novel	Y204*	0.19
UCEC	chrX	71121615	Missense_Mutation	novel	F300L	0.36
UCEC	chrX	71130083	Missense_Mutation	novel	D1306Y	0.11
UCEC	chrX	71132513	Nonsense_Mutation	novel	E1464*	0.35
UCEC	chrX	71135247	Silent	novel	K1673K	0.36
UCEC	chrX	71126435	Missense_Mutation	novel	L879R	0.46
UCEC	chrX	71129731	Missense_Mutation	novel	E1248V	0.24
UCEC	chrX	71137346	Missense_Mutation	rs200663107	A1904V	0.15
UCEC	chrX	71141265	Silent	novel	Q2101Q	0.27
UCEC	chrX	71119693	Missense_Mutation	novel	S71F	0.37
UCEC	chrX	71122836	Nonsense_Mutation	novel	R483*	0.43
UCEC	chrX	71134816	Missense_Mutation	novel	R1611C	0.33
UCEC	chrX	71136377	Missense_Mutation	novel	V1708F	0.16
UCEC	chrX	71123635	Silent	rs763388314	I553I	0.42
UCEC	chrX	71122531	Silent	NA	I424I	0.5
UCEC	chrX	71127957	Missense_Mutation	novel	R1016C	0.62
UCEC	chrX	71136307	Missense_Mutation	novel	K1684N	0.47
UCEC	chrX	71119383	Missense_Mutation	novel	T37M	0.43
UCEC	chrX	71128685	Missense_Mutation	novel	R1148C	0.49
UCEC	chrX	71132522	Nonsense_Mutation	novel	R1467*	0.36
UCEC	chrX	71137792	Frame_Shift_Del	novel	*S1967Afs19**	0.22
UCEC	chrX	71131595	Missense_Mutation	novel	L1365F	0.6
UCEC	chrX	71129691	Silent	NA	L1235L	0.33
UCEC	chrX	71120985	Missense_Mutation	rs374780236	I190V	0.12
UCEC	chrX	71132178	Missense_Mutation	NA	S1409G	0.07
UCEC	chrX	71128655	Missense_Mutation	NA	R1138W	0.44
UCEC	chrX	71122837	Missense_Mutation	NA	R483Q	0.39
UCEC	chrX	71142398	3'UTR	novel		0.49
UCEC	chrX	71129194	Missense_Mutation	novel	N1186D	0.16
UCEC	chrX	71123170	Missense_Mutation	NA	R521C	0.49
UCEC	chrX	71118795	Missense_Mutation	novel	L14R	0.1
UCEC	chrX	71118796	Silent	novel	L14L	0.1
UCEC	chrX	71133159	Missense_Mutation	novel	D1522N	0.39
UCEC	chrX	71121408	Missense_Mutation	novel	L273I	0.15
UCEC	chrX	71128025	Silent	novel	G1038G	0.17
UCEC	chrX	71134450	Missense_Mutation	novel	D1571N	0.39
UCEC	chrX	71135250	Missense_Mutation	novel	K1674N	0.13
UCEC	chrX	71123170	Missense_Mutation	NA	R521C	0.21
UCEC	chrX	71124223	Silent	novel	L603L	0.39
UCEC	chrX	71126378	Missense_Mutation	novel	A860V	0.43
UCEC	chrX	71127333	Splice_Region	novel		0.24
UCEC	chrX	71136419	Missense_Mutation	novel	R1722W	0.31
UCEC	chrX	71137871	Missense_Mutation	novel	L1991P	0.18
UCEC	chrX	71123192	Missense_Mutation	novel	L528H	0.13
UCEC	chrX	71132892	Missense_Mutation	NA	C1488Y	0.22
UCEC	chrX	71119702	In_Frame_Del	novel	S75_C83del	0.15
UCEC	chrX	71126100	Silent	novel	I829I	0.45
UCEC	chrX	71127444	Missense_Mutation	novel	K986N	0.26
UCEC	chrX	71134796	Missense_Mutation	novel	G1604D	0.38
UCEC	chrX	71129378	Missense_Mutation	novel	R1214S	0.3
UCEC	chrX	71127938	Silent	novel	E1009E	0.28
UCEC	chrX	71128685	Missense_Mutation	novel	R1148C	0.28
UCEC	chrX	71136629	Missense_Mutation	novel	R1792C	0.4
UCEC	chrX	71137370	Missense_Mutation	rs767294730	R1912H	0.36
UCEC	chrX	71120133	Missense_Mutation	novel	E172D	0.37
UCEC	chrX	71121110	Silent	novel	R231R	0.43
UCEC	chrX	71126056	Missense_Mutation	NA	R815W	0.41
UCEC	chrX	71122271	Silent	novel	G391G	0.44
UCEC	chrX	71121343	Missense_Mutation	novel	R251K	0.11
UCEC	chrX	71136284	Missense_Mutation	NA	L1677I	0.48
UCEC	chrX	71121380	Missense_Mutation	novel	E263D	0.06
UCEC	chrX	71127974	Missense_Mutation	rs797045698	F1021L	0.35
UCEC	chrX	71125041	Missense_Mutation	novel	E707D	0.14
UCEC	chrX	71142424	3'UTR	novel		0.13
UCEC	chrX	71123226	Missense_Mutation	NA	E539D	0.25
UCEC	chrX	71121639	Missense_Mutation	novel	Q308H	0.3
UCEC	chrX	71125068	Missense_Mutation	NA	E716D	0.23
UCEC	chrX	71141940	Missense_Mutation	novel	R2156W	0.2
UCEC	chrX	71141913	Nonsense_Mutation	novel	Q2147*	0.33
UCEC	chrX	71132907	Missense_Mutation	novel	D1493G	0.23
UCEC	chrX	71123626	Silent	NA	K550K	0.15
UCEC	chrX	71141242	In_Frame_Del	novel	Q2113_Q2115del	0.23
UCEC	chrX	71126090	Missense_Mutation	novel	A826V	0.31
UCEC	chrX	71136461	Missense_Mutation	novel	A1736T	0.12
UCEC	chrX	71118821	Missense_Mutation	NA	D23Y	0.58
UCEC	chrX	71136942	Missense_Mutation	novel	H1822Y	0.14
UCEC	chrX	71127966	Missense_Mutation	novel	P1019S	0.22
UCEC	chrX	71132956	Missense_Mutation	novel	Q1509H	0.28
UCEC	chrX	71127101	Frame_Shift_Del	novel	*N940Tfs16**	0.13
UCEC	chrX	71132906	Missense_Mutation	novel	D1493N	0.28
UCEC	chrX	71123690	Nonsense_Mutation	novel	Q572*	0.41
UCEC	chrX	71125400	Missense_Mutation	NA	G759V	0.46
UCEC	chrX	71140701	Silent	rs370522888	G2037G	0.24
UCEC	chrX	71119718	Missense_Mutation	NA	E79D	0.44
UCEC	chrX	71122571	Missense_Mutation	rs771266719	R438C	0.49
UCEC	chrX	71124841	Missense_Mutation	NA	F684L	0.42
UCEC	chrX	71119478	Splice_Site	novel	X68_splice	0.62
UCEC	chrX	71125426	Missense_Mutation	novel	R768C	0.38
UCEC	chrX	71123171	Missense_Mutation	NA	R521H	0.4
UCEC	chrX	71141269	In_Frame_Del	novel	Q2115del	0.12
UCEC	chrX	71118806	Missense_Mutation	NA	R18W	0.44
UCEC	chrX	71119718	Missense_Mutation	NA	E79D	0.4
UCEC	chrX	71124168	Missense_Mutation	rs747113641	R585Q	0.31
UCEC	chrX	71130152	Nonsense_Mutation	NA	R1329*	0.22
UCEC	chrX	71136535	Missense_Mutation	NA	E1760D	0.23
UCEC	chrX	71125440	Silent	novel	K772K	0.34
UCEC	chrX	71142193	Missense_Mutation	novel	S2170N	0.3
UCEC	chrX	71129818	Missense_Mutation	NA	V1277A	0.3
UCEC	chrX	71121084	Missense_Mutation	novel	P223S	0.7
UCEC	chrX	71129408	Missense_Mutation	novel	L1224I	0.23
UCEC	chrX	71133120	Splice_Region	novel		0.1
UCEC	chrX	71129785	Missense_Mutation	rs587780391	R1266H	0.41
UCEC	chrX	71135107	Missense_Mutation	rs776748297	R1627C	0.16
UCEC	chrX	71123171	Missense_Mutation	NA	R521H	0.41
UCEC	chrX	71134816	Missense_Mutation	novel	R1611C	0.07
UCEC	chrX	71137320	Silent	novel	T1895T	0.08
UCEC	chrX	71137614	Silent	NA	S1935S	0.31
UCEC	chrX	71129785	Missense_Mutation	rs587780391	R1266H	0.32
UCEC	chrX	71125122	Silent	NA	Y734Y	0.4
UCEC	chrX	71120158	Missense_Mutation	novel	D181Y	0.38
UCEC	chrX	71124182	Missense_Mutation	novel	R590W	0.41
UCEC	chrX	71118819	Missense_Mutation	NA	P22R	0.3
UCEC	chrX	71121596	Missense_Mutation	novel	S294Y	0.44
UCEC	chrX	71142377	3'UTR	novel		0.25
UCS	chrX	71130201	Missense_Mutation	novel	K1345T	0.22
UCS	chrX	71137019	Silent	novel	P1847P	0.41
UCS	chrX	71118821	Missense_Mutation	NA	D23Y	0.39
UCS	chrX	71124249	Missense_Mutation	novel	N612T	0.39
UCS	chrX	71132513	Nonsense_Mutation	novel	E1464*	0.37
UCS	chrX	71124182	Missense_Mutation	novel	R590W	0.43
UVM	chrX	71119761	Missense_Mutation	novel	P94S	1

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.0686	0.0018563
GBM	DEL	0.0329	3.2518e-06
KIRC	AMP	0.0208	2.0306e-05
KIRP	AMP	0.0903	0.15981
LUAD	DEL	0.0833	0.010111
PAAD	AMP	0.038	0.16151
SARC	DEL	0.2412	0.0086757
TGCT	AMP	0.0867	7.0307e-05
THCA	DEL	0	0.21991

Survival Analysis

Cancer	P-value	Q-value
SARC	0.038	Kaplan-Meier Survival Analysis
KIRP	0.035	Kaplan-Meier Survival Analysis
KICH	0.018	Kaplan-Meier Survival Analysis
GBM	0.033	Kaplan-Meier Survival Analysis
LUAD	0.033	Kaplan-Meier Survival Analysis
UVM	0.048	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000184634 (Gene tree)
Gene ID: 9968
Gene Symbol: MED12
Alias: CAGH45|HOPA|OPA1|TRAP230|KIAA0192|OKS|TNRC11|FGS1
Full Name: mediator complex subunit 12
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 23,899 bases
Position: chrX:71,118,556-71,142,454
Accession: 11957
RBP type: non-canonical RBP
Summary: The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
30456381	CARM1 methylates MED12 to regulate its RNA-binding ability.	Life Sci Alliance	2018 Sep 19	Cheng D	doi: 10.26508/lsa.201800117
16712834	Zebrafish Trap230/Med12 is required as a coactivator for Sox9-dependent neural crest, cartilage and ear development.	Dev Biol	2006 Aug 1	Rau MJ	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000374080	MED12-202	6795	-	ENSP00000363193	2177 (aa)	-	Q93074
ENST00000460771	MED12-206	330	-	-	- (aa)	-	-
ENST00000471663	MED12-208	439	-	-	- (aa)	-	-
ENST00000489199	MED12-209	349	-	-	- (aa)	-	-
ENST00000462984	MED12-207	631	-	-	- (aa)	-	-
ENST00000429213	MED12-204	389	-	ENSP00000399084	130 (aa)	-	H7C191
ENST00000374102	MED12-203	6827	-	ENSP00000363215	2176 (aa)	-	Q93074
ENST00000333646	MED12-201	6977	-	ENSP00000333125	2027 (aa)	-	Q7Z3Z5
ENST00000444034	MED12-205	752	-	ENSP00000404373	251 (aa)	-	H7C274

Gene Model

Click here to download ENSG00000184634's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04919	Thyroid hormone signaling pathway	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000184634's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000151	ubiquitin ligase complex	-	IEA	Component
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	-	IEA	Function
GO:0001843	neural tube closure	-	IEA	Process
GO:0003682	chromatin binding	-	IEA	Function
GO:0003712	transcription coregulator activity	10198638.12218053.	IDA	Function
GO:0003713	transcription coactivator activity	21873635.	IBA	Function
GO:0003713	transcription coactivator activity	12037571.	IDA	Function
GO:0005515	protein binding	21293490.23178117.26496610.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	10235267.17000779.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006357	regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0006367	transcription initiation from RNA polymerase II promoter	12218053.	IDA	Process
GO:0006367	transcription initiation from RNA polymerase II promoter	-	TAS	Process
GO:0007492	endoderm development	-	IEA	Process
GO:0007507	heart development	-	IEA	Process
GO:0008013	beta-catenin binding	-	IEA	Function
GO:0008022	protein C-terminus binding	17000779.	IPI	Function
GO:0014003	oligodendrocyte development	-	IEA	Process
GO:0014044	Schwann cell development	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016567	protein ubiquitination	-	IEA	Process
GO:0016592	mediator complex	21873635.	IBA	Component
GO:0016592	mediator complex	10198638.12037571.	IDA	Component
GO:0019827	stem cell population maintenance	-	IEA	Process
GO:0019904	protein domain specific binding	11984006.	IPI	Function
GO:0021510	spinal cord development	-	IEA	Process
GO:0030374	nuclear receptor transcription coactivator activity	10235266.	NAS	Function
GO:0036342	post-anal tail morphogenesis	-	IEA	Process
GO:0042809	vitamin D receptor binding	10235266.	NAS	Function
GO:0045893	positive regulation of transcription, DNA-templated	10198638.	IDA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	12037571.	IDA	Process
GO:0046966	thyroid hormone receptor binding	10198638.	IDA	Function
GO:0048702	embryonic neurocranium morphogenesis	-	IEA	Process
GO:0060070	canonical Wnt signaling pathway	-	IEA	Process
GO:0060071	Wnt signaling pathway, planar cell polarity pathway	-	IEA	Process
GO:0061630	ubiquitin protein ligase activity	-	IEA	Function
GO:0090245	axis elongation involved in somitogenesis	-	IEA	Process
GO:1990403	embryonic brain development	-	IEA	Process

EuRBPDB

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Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.