EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
21868628MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas.Science2011 Oct 14Mkinen Ndoi: 10.1126/science.1208930
25964426Clonally related uterine leiomyomas are common and display branched tumor evolution.Hum Mol Genet2015 Aug 1Mehine Mdoi: 10.1093/hmg/ddv177
22768200MED12 alterations in both human benign and malignant uterine soft tissue tumors.PLoS One2012P??rot Gdoi: 10.1371/journal.pone.0040015
28183795MED12 is recurrently mutated in Middle Eastern colorectal cancer.Gut2018 AprSiraj AKdoi: 10.1136/gutjnl-2016-313334
28634282Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of MED12 and RBM10 as Novel Thyroid Cancer Genes Associated with Tumor Virulence.Clin Cancer Res2017 Oct 1Ibrahimpasic Tdoi: 10.1158/1078-0432.CCR-17-1183
29315289MED12, TERT promoter and RBM15 mutations in primary and recurrent phyllodes tumours.Br J Cancer2018 JanGarcia-Dios DAdoi: 10.1038/bjc.2017.450
23178117MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling.Cell2012 Nov 21Huang Sdoi: 10.1016/j.cell.2012.10.035.
24938407MED12 overexpression is a frequent event in castration-resistant prostate cancer.Endocr Relat Cancer2014 AugShaikhibrahim Zdoi: 10.1530/ERC-14-0171
26383637Somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms.Prostate2016 JanKmpjrvi Kdoi: 10.1002/pros.23092
28055980Immunohistochemical profiling of receptor tyrosine kinases, MED12, and TGF-βRII of surgically resected small cell lung cancer, and the potential of c-kit as a prognostic marker.Oncotarget2017 Jun 13Yokouchi Hdoi: 10.18632/oncotarget.14410.
29628309JMJD6 Licenses ERα-Dependent Enhancer and Coding Gene Activation by Modulating the Recruitment of the CARM1/MED12 Co-activator Complex.Mol Cell2018 Apr 19Gao WWdoi: 10.1016/j.molcel.2018.03.006

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchrX71132463Missense_MutationnovelA1447D0.09
BLCAchrX71121014Missense_MutationnovelQ199H0.75
BLCAchrX71137306Missense_MutationnovelS1891A0.48
BLCAchrX71120131Missense_MutationNAE172Q0.36
BLCAchrX71121682Missense_MutationnovelQ323E0.36
BLCAchrX71129390Missense_MutationNAG1218R0.23
BLCAchrX71125371Missense_MutationNAE749D0.64
BLCAchrX71137184Splice_Regionnovel0.23
BLCAchrX71120038Missense_MutationNAE141Q0.54
BLCAchrX71130102Missense_MutationnovelL1312S0.83
BLCAchrX71123111Missense_MutationnovelD501G0.48
BLCAchrX71118851Missense_Mutationrs769202858E33K0.33
BLCAchrX71119403In_Frame_DelnovelG44_F45del0.5
BLCAchrX71118851Missense_Mutationrs769202858E33K0.43
BLCAchrX71118833Missense_MutationNAQ27E0.38
BLCAchrX71121065SilentNAG216G0.35
BLCAchrX71118845Missense_MutationnovelQ31E0.18
BLCAchrX71121678SilentnovelS321S0.28
BLCAchrX71121667Missense_MutationnovelH318D0.8
BLCAchrX71130092Missense_MutationnovelD1309N0.46
BLCAchrX71127094Silentrs766716404L937L0.93
BLCAchrX71126470Missense_MutationNAD891N0.09
BLCAchrX71128116Missense_MutationnovelD1069Y0.2
BLCAchrX71135182Missense_MutationNAE1652K0.91
BLCAchrX71136617Missense_MutationnovelK1788E0.75
BLCAchrX71137560Splice_RegionnovelQ1917Q0.56
BLCAchrX71119839Missense_MutationnovelL120V0.77
BRCAchrX71121118Missense_MutationNAD234V0.48
BRCAchrX71128603Missense_MutationnovelS1120R0.08
BRCAchrX71137242SilentNAP1869P0.34
BRCAchrX71136981Frame_Shift_DelnovelQ1836Lfs*570.34
BRCAchrX71132440SilentNAV1439V0.17
BRCAchrX71132189Missense_MutationNAK1412N0.14
BRCAchrX71136454SilentNAR1733R0.11
BRCAchrX71132918Nonsense_MutationNAE1497*0.27
BRCAchrX71136433Frame_Shift_InsNAL1730Tfs*20.26
BRCAchrX71132535Missense_MutationnovelK1471M0.09
BRCAchrX711423123'UTRnovel0.27
BRCAchrX71125410SilentNAK762K0.46
BRCAchrX71121075Missense_MutationNAG220R0.28
BRCAchrX71121682Nonsense_MutationnovelQ323*0.03
BRCAchrX71125071Missense_MutationNAK717N0.19
BRCAchrX71136393Missense_Mutationrs374390933R1713Q0.32
BRCAchrX71121369Nonsense_MutationnovelE260*0.04
BRCAchrX71136402Missense_MutationNAR1716Q0.45
BRCAchrX71141346Missense_MutationnovelQ2128H0.2
BRCAchrX71128316Missense_MutationnovelL1077Q0.1
BRCAchrX71130196In_Frame_InsnovelI1344dup0.34
BRCAchrX71137795Missense_MutationnovelP1966A0.08
BRCAchrX71141950Missense_MutationNAQ2159R0.44
BRCAchrX71137773Silentrs370235478G1958G0.17
BRCAchrX71126112Missense_MutationNAF833L0.25
BRCAchrX71120987SilentNAI190I0.17
BRCAchrX71119386In_Frame_DelnovelL39_P49del0.13
BRCAchrX71135164Nonsense_MutationNAR1646*0.42
BRCAchrX71132094Missense_MutationNAN1381Y0.12
BRCAchrX71120139Missense_MutationNAK174N0.23
BRCAchrX71122770Missense_MutationNAE461K0.16
BRCAchrX71127020Missense_MutationNAD913Y0.47
BRCAchrX71137824SilentNAS1975S0.22
BRCAchrX71141964Missense_MutationNAN2164D0.32
BRCAchrX71129739Missense_MutationNAE1251K0.14
BRCAchrX71132454Nonsense_MutationnovelL1444*0.06
CESCchrX71118821Missense_MutationNAD23Y0.48
CESCchrX71142156Splice_SitenovelX2164_splice0.41
CESCchrX71124275Nonsense_MutationNAR621*0.31
CESCchrX71137219Missense_Mutationrs200279192R1862C0.3
CESCchrX71125415Missense_MutationNAR764Q0.41
CESCchrX71126338Splice_RegionNA0.21
CESCchrX71121637Missense_MutationNAQ308E0.21
CESCchrX71122303Missense_MutationNAS402Y0.24
CESCchrX71128414Missense_MutationnovelF1110L0.18
CESCchrX71122607Missense_MutationNAG450R0.12
CESCchrX71119807Missense_MutationNAS109F0.26
CESCchrX71122550Missense_MutationnovelR431W0.43
CESCchrX71125476Frame_Shift_InsnovelG786Rfs*60.38
CESCchrX71134412Missense_MutationnovelA1558V0.3
CESCchrX71137267Missense_MutationnovelL1878M0.33
CESCchrX71119683Splice_Regionnovel0.57
CESCchrX71131572Missense_MutationNAR1357H0.32
CESCchrX71134755SilentnovelI1590I0.09
CESCchrX71129147Missense_MutationnovelR1170Q0.56
CESCchrX71123179Missense_MutationnovelV524M0.52
CESCchrX71121718Nonsense_MutationNAQ335*0.24
CESCchrX71118821Missense_MutationNAD23Y0.26
CESCchrX71119683Splice_Regionnovel0.49
CESCchrX71128655Missense_MutationNAR1138W0.22
CESCchrX71121723SilentNAP336P0.25
COADchrX71137563SilentNAS1918S0.56
COADchrX71121387Missense_MutationNAR266C0.33
COADchrX71126059Nonsense_MutationNAR816*0.17
COADchrX71126063Missense_Mutationrs749801457R817H0.23
COADchrX71129814Missense_MutationNAD1276N0.49
COADchrX71141238SilentnovelQ2092Q0.11
COADchrX71121744SilentNAS343S0.77
COADchrX71125449SilentNAT775T0.16
COADchrX71141271SilentNAQ2103Q0.58
COADchrX71134843SilentNAL1620L0.38
COADchrX71135163SilentNAT1645T0.26
COADchrX71132936Missense_MutationNAL1503I0.07
COADchrX71118853Missense_MutationNAE33D0.32
COADchrX71136312Missense_MutationNAS1686L0.07
COADchrX71121136Missense_MutationnovelA240V0.09
COADchrX71124334SilentNAP640P0.36
COADchrX71127074Missense_MutationNAR931G0.79
COADchrX71140702Missense_Mutationrs762612521V2038I0.75
COADchrX71131572Missense_MutationNAR1357H0.28
COADchrX71135161Missense_MutationnovelT1645A0.12
COADchrX71130059Missense_MutationNAK1298E0.47
COADchrX71127036Missense_MutationNAY918C0.63
COADchrX71125487Missense_MutationNAA788E0.29
COADchrX71118853Missense_MutationNAE33D0.89
COADchrX71128649Missense_MutationNAI1136V0.85
COADchrX71141247In_Frame_Insrs777164189Q2115dup0.76
COADchrX71123617SilentNAA547A0.31
COADchrX71132481Missense_MutationNAK1453T0.18
COADchrX71142203Missense_MutationnovelI2173M0.25
COADchrX711185925'Flanknovel0.3
COADchrX71140791Silentrs375793297Q2067Q0.19
COADchrX71130173Frame_Shift_DelNAE1337Kfs*80.26
COADchrX71123144Nonsense_MutationnovelS513_C514ins*0.03
COADchrX71131570Missense_MutationNAM1356I0.31
COADchrX71121436Missense_MutationnovelR282Q0.05
COADchrX71132516Missense_MutationNAR1465C0.59
COADchrX71127074Missense_MutationnovelR931W0.12
DLBCchrX71122270Missense_MutationnovelG391V0.34
DLBCchrX71132517Missense_MutationnovelR1465H0.11
ESCAchrX71120083Missense_MutationnovelA156S0.19
ESCAchrX71122524Missense_MutationnovelR422L0.06
GBMchrX71121645Missense_MutationnovelD310E0.14
GBMchrX71137913Missense_MutationnovelT2005N0.31
GBMchrX71121580Nonsense_MutationNAQ289*0.21
GBMchrX71121344Missense_MutationnovelR251S0.16
GBMchrX71122787Frame_Shift_InsnovelS467Efs*30.04
GBMchrX71122311Missense_MutationnovelP405S0.26
GBMchrX71127075Missense_MutationnovelR931Q0.07
GBMchrX71127980Silentrs753751305I1023I0.61
GBMchrX71128645SilentnovelI1134I0.12
GBMchrX71129790Missense_MutationnovelI1268F0.35
GBMchrX71122562Missense_MutationNAV435L0.5
GBMchrX71140855Missense_MutationNAR2089W0.87
GBMchrX71132100Missense_MutationNAA1383T0.45
GBMchrX71118793SilentnovelP13P0.56
GBMchrX71119392Missense_MutationnovelN40T1
GBMchrX71119877Missense_MutationnovelK132N0.26
GBMchrX71120080Missense_MutationnovelR155W0.08
GBMchrX71127346Missense_MutationnovelV954I0.77
GBMchrX71121346Missense_MutationnovelH252R0.8
GBMchrX71125098Silentrs763782632Y726Y0.2
HNSCchrX711422453'UTRnovel0.29
HNSCchrX71127368Missense_Mutationrs766598254R961Q0.26
HNSCchrX71129343Missense_MutationNAS1202F0.49
HNSCchrX71118766Missense_MutationnovelF4L0.67
HNSCchrX71126993Missense_MutationnovelE904Q0.07
HNSCchrX71131578Missense_MutationnovelS1359Y0.27
HNSCchrX71129736Missense_MutationnovelP1250S0.36
HNSCchrX71129737Missense_MutationnovelP1250L0.36
HNSCchrX71121039Missense_MutationnovelG208W0.56
HNSCchrX71136913Missense_MutationnovelY1812C0.24
HNSCchrX71128010SilentnovelT1033T0.1
HNSCchrX71137626Missense_MutationNAQ1939H0.1
HNSCchrX71122343SilentnovelQ415Q0.26
HNSCchrX71118800Missense_MutationnovelR16G0.11
HNSCchrX71127892Splice_SitenovelX994_splice0.32
HNSCchrX71125427Missense_MutationnovelR768L0.39
HNSCchrX71133175Missense_MutationnovelQ1527R0.63
HNSCchrX71119879Splice_SitenovelX132_splice0.31
HNSCchrX71130145SilentnovelY1326Y0.13
HNSCchrX71136453Missense_Mutationrs754537871R1733Q0.71
KIRCchrX71140719SilentNAR2043R0.15
KIRCchrX71122338Missense_MutationNAT414A0.28
KIRCchrX71127102Missense_MutationnovelN940I0.18
KIRCchrX71128401Missense_MutationnovelN1105K0.02
KIRCchrX71121331Missense_MutationNAG247V0.27
KIRPchrX71129348Missense_MutationNAD1204Y0.23
KIRPchrX71135194Missense_MutationnovelS1656A0.39
KIRPchrX71130188Missense_Mutationrs777250096R1341W0.49
LAMLchrX71136318Nonsense_MutationnovelW1688*0.97
LAMLchrX71126383Missense_MutationnovelG862S0.06
LAMLchrX71127367Missense_Mutationrs80338758R961W0.52
LAMLchrX71123632SilentnovelS552S0.2
LAMLchrX71122245Missense_MutationnovelL383V0.12
LGGchrX71137211Missense_Mutationrs763700798R1859H0.23
LGGchrX71133136Nonsense_MutationnovelW1514*0.4
LGGchrX71131558Missense_MutationNAD1352E0.12
LGGchrX71118717Missense_Mutationnovel0.43
LGGchrX71126087Missense_MutationNAT825N0.18
LGGchrX71121407Missense_MutationNAL272F0.1
LGGchrX71120097SilentnovelI160I0.09
LGGchrX71124182Missense_MutationnovelR590W0.08
LGGchrX71127373Missense_MutationnovelD963N0.45
LGGchrX71129415Missense_MutationnovelA1226D0.58
LGGchrX71132513Missense_MutationnovelE1464K0.5
LGGchrX71126449Missense_MutationNAL884V0.23
LGGchrX71119404Missense_Mutationrs199469672G44A0.28
LIHCchrX71132398SilentnovelV1425V0.28
LIHCchrX71120988Missense_MutationnovelT191S0.04
LIHCchrX71134792Missense_MutationnovelQ1603K0.31
LIHCchrX71129424Missense_MutationNAV1229E0.84
LIHCchrX71127057Missense_MutationnovelC925F0.67
LIHCchrX71118782Missense_MutationNAE10Q0.74
LIHCchrX711186295'Flanknovel0.92
LUADchrX71121708SilentNAT331T0.55
LUADchrX71125429Missense_Mutationrs755014778H769N0.28
LUADchrX71128600Splice_RegionNAV1119V0.35
LUADchrX71129340Missense_MutationnovelS1201Y0.15
LUADchrX71121055Missense_MutationnovelG213V0.29
LUADchrX71121056SilentnovelG213G0.29
LUADchrX71126050Nonsense_MutationNAQ813*0.79
LUADchrX71127075Missense_MutationnovelR931P0.69
LUADchrX71132087SilentNAL1378L0.37
LUADchrX71132416SilentNAL1431L0.38
LUADchrX71119752Missense_MutationnovelR91C0.6
LUADchrX71119753Missense_MutationnovelR91L0.63
LUADchrX71136470SilentnovelL1739L0.83
LUADchrX71125143SilentnovelP741P0.18
LUADchrX71141880Splice_Regionnovel0.46
LUADchrX71120146Frame_Shift_InsnovelH179Dfs*420.62
LUADchrX71123178Missense_MutationNAM523I0.66
LUADchrX71126057Missense_MutationNAR815L0.55
LUADchrX71125427Missense_MutationnovelR768P0.4
LUADchrX71121080SilentNAP221P0.1
LUADchrX71135120Missense_MutationnovelS1631I0.92
LUADchrX71126069Missense_MutationnovelR819L0.07
LUADchrX71132507Missense_MutationNAR1462C0.27
LUADchrX71125415Missense_MutationNAR764Q0.26
LUADchrX71121152Splice_RegionNAQ245Q0.24
LUADchrX71137747Missense_MutationNAH1950Y0.1
LUADchrX71127894Missense_Mutationrs771092011D995N0.39
LUADchrX71123102Nonsense_MutationnovelS498*0.08
LUADchrX71137880Missense_MutationnovelR1994L0.13
LUADchrX71132443Missense_MutationnovelQ1440H0.31
LUADchrX71121096Nonsense_MutationnovelE227*0.4
LUADchrX71125710Missense_MutationNAL807V0.18
LUADchrX71121777Missense_MutationnovelQ354H0.11
LUADchrX71123140Missense_MutationNAA511S0.15
LUADchrX71136955Missense_MutationNAP1826L0.12
LUADchrX71123626Missense_MutationNAK550N0.44
LUADchrX71137943Missense_MutationnovelR2015M0.23
LUADchrX71137944Splice_SitenovelX2015_splice0.23
LUADchrX71123211SilentNAA534A0.21
LUADchrX71140663Missense_MutationnovelP2025T0.15
LUADchrX71136417Missense_MutationnovelQ1721L0.35
LUADchrX71127421Missense_MutationNAY979H0.05
LUADchrX71121781Missense_MutationNAR356W0.43
LUADchrX71136569Missense_MutationnovelP1772T0.21
LUADchrX71128367Missense_MutationNAG1094E0.2
LUADchrX71127392Missense_MutationnovelR969P0.1
LUADchrX71127388Missense_MutationnovelE968Q0.22
LUADchrX71128321Missense_MutationnovelA1079S0.17
LUADchrX71134747Missense_Mutationrs767396596V1588M0.21
LUADchrX71128391Missense_MutationnovelS1102Y0.27
LUADchrX71121096Missense_MutationNAE227Q0.27
LUADchrX71129340Missense_MutationnovelS1201Y0.08
LUSCchrX71137865Missense_MutationnovelR1989H0.27
LUSCchrX71121348Missense_MutationnovelE253Q0.28
LUSCchrX71119803SilentnovelR108R0.57
LUSCchrX71122304SilentnovelS402S0.51
LUSCchrX71128036Missense_MutationNAS1042I0.29
LUSCchrX71120170Missense_MutationnovelE185K0.05
LUSCchrX71137364Missense_MutationnovelR1910H0.19
LUSCchrX71137835Missense_MutationnovelS1979C0.19
LUSCchrX71132176Missense_MutationnovelP1408H0.32
LUSCchrX71121055Missense_MutationnovelG213V0.19
LUSCchrX71128648SilentnovelL1135L0.17
LUSCchrX71132072Splice_SiteNAX1374_splice0.23
LUSCchrX71132073Nonsense_MutationNAE1374*0.22
LUSCchrX71129408Missense_MutationNAL1224V0.36
LUSCchrX71136393Missense_MutationnovelR1713P0.09
LUSCchrX71126386Missense_MutationnovelM863L0.37
LUSCchrX71137812SilentnovelQ1971Q0.63
LUSCchrX71130083Missense_MutationnovelD1306N0.59
LUSCchrX71123615Missense_MutationNAA547P0.94
LUSCchrX71130141Missense_MutationnovelC1325F0.52
LUSCchrX71124973Splice_Regionnovel0.23
LUSCchrX71124785Missense_MutationNAM666V0.7
LUSCchrX71125366Missense_MutationnovelH748N0.16
LUSCchrX71131604Missense_MutationNAK1368Q0.21
LUSCchrX71119779Missense_MutationnovelD100Y0.09
LUSCchrX71131611Missense_MutationnovelT1370N0.29
LUSCchrX71125687Missense_MutationnovelL799R0.19
LUSCchrX71125688SilentnovelL799L0.2
LUSCchrX71122756Missense_MutationnovelV456A0.2
MESOchrX71130144Missense_MutationnovelY1326S0.67
OVchrX71127345SilentnovelG953G0.12
OVchrX71136455Missense_MutationnovelP1734S0.18
OVchrX71128019SilentnovelY1036Y0.1
OVchrX71136550Frame_Shift_InsnovelK1768Qfs*30.17
OVchrX711423793'UTRnovel0.52
OVchrX71132953Missense_MutationNAH1508Q0.23
OVchrX711423013'UTRnovel0.1
OVchrX71128630SilentnovelA1129A0.06
OVchrX71140714Missense_Mutationrs755577187V2042I0.45
OVchrX71122329Missense_MutationnovelS411G0.45
OVchrX71133127Missense_MutationnovelV1511G0.05
OVchrX71141924Frame_Shift_InsnovelT2151Qfs*690.07
PAADchrX71128372Missense_MutationnovelL1096I0.26
PCPGchrX71130151Missense_MutationnovelH1328Q0.57
PRADchrX71129408Missense_MutationNAL1224F0.3
PRADchrX71121770Missense_MutationnovelC352F0.1
PRADchrX71129406Missense_MutationNAV1223G0.52
PRADchrX71129405Missense_MutationNAV1223L0.43
PRADchrX71128673Missense_MutationNAE1144Q0.58
PRADchrX71129408Missense_MutationNAL1224F0.19
PRADchrX71129405Missense_MutationNAV1223L0.86
PRADchrX71129408Missense_MutationNAL1224F0.09
READchrX71122753Missense_Mutationrs760696164R455Q0.57
READchrX71119862Silentrs202125318T127T0.18
READchrX71121105Missense_MutationNAI230V0.93
READchrX71118852Missense_MutationNAE33G0.75
READchrX71140855Missense_MutationNAR2089W0.3
READchrX71120057Missense_MutationNAA147G0.42
READchrX71129159Missense_MutationNAR1174H0.52
SARCchrX71119404Missense_Mutationrs199469672G44D0.76
SARCchrX71130174Missense_MutationnovelG1336V0.11
SARCchrX71121607Missense_MutationnovelA298S0.12
SARCchrX71132878SilentnovelS1483S0.15
SKCMchrX71120025SilentnovelF136F0.14
SKCMchrX71132107Missense_Mutationrs771349148A1385V0.3
SKCMchrX71132405Missense_MutationNAV1428M0.31
SKCMchrX71121107SilentnovelI230I0.17
SKCMchrX71119807Missense_MutationNAS109F0.48
SKCMchrX71123686SilentnovelL570L1
SKCMchrX71124804Missense_MutationnovelS672F0.93
SKCMchrX71123647SilentnovelS557S1
SKCMchrX71123100SilentNAS497S0.57
SKCMchrX71136569Missense_MutationNAP1772S0.63
SKCMchrX71121065SilentNAG216G0.3
SKCMchrX71137830SilentNAH1977H0.91
SKCMchrX71132197Missense_MutationnovelP1415L0.49
SKCMchrX71140731SilentnovelI2047I0.25
SKCMchrX71122543SilentnovelI428I0.75
SKCMchrX71121748Missense_Mutationrs761157306P345S0.8
SKCMchrX71122532Missense_MutationNAE425K0.09
SKCMchrX71126985Missense_MutationNAS901N0.88
SKCMchrX71136910Missense_MutationNAP1811L0.17
SKCMchrX71124332Missense_MutationNAP640S0.43
SKCMchrX71121667Missense_MutationnovelH318Y0.62
SKCMchrX71130152Nonsense_MutationNAR1329*0.24
SKCMchrX71136472SilentNAL1739L0.77
SKCMchrX71123099Missense_MutationNAS497F0.25
SKCMchrX711422303'UTRrs7699909080.19
SKCMchrX71136492Missense_MutationnovelP1746Q0.57
SKCMchrX71123712Missense_MutationNAP579L0.33
SKCMchrX71137774Missense_MutationNAP1959S0.38
SKCMchrX71128651Silentrs756127182I1136I0.17
SKCMchrX71127380Missense_MutationnovelS965F0.35
SKCMchrX71123669Missense_MutationnovelI565L0.14
SKCMchrX71129807SilentnovelA1273A0.28
SKCMchrX71137736Missense_MutationnovelP1946L0.25
SKCMchrX71136900Missense_Mutationrs372271659R1808W0.56
SKCMchrX71118769SilentNAG5G0.65
STADchrX71124836Missense_MutationNAD683H0.15
STADchrX71129408Missense_MutationNAL1224F0.87
STADchrX71126384Missense_MutationnovelG862D0.71
STADchrX71137226Missense_MutationNAP1864Q0.09
STADchrX71136560Missense_MutationNAT1769P0.3
STADchrX71124160Splice_Regionrs773240125T582T0.25
STADchrX71121756SilentNAS347S0.8
STADchrX71136420Missense_MutationNAR1722Q0.56
STADchrX71127368Missense_Mutationrs766598254R961Q0.33
STADchrX71121120Missense_MutationNAY235H0.7
STADchrX71122582Silentrs371928861F441F0.25
STADchrX71128624SilentNAS1127S0.39
STADchrX71129839Missense_MutationNAR1284H0.25
STADchrX71121391Missense_MutationNAP267L0.11
STADchrX71121387Missense_MutationNAR266C0.27
STADchrX71141928Missense_MutationNAA2152T0.18
STADchrX71121599Missense_MutationnovelR295H0.16
STADchrX71137332SilentnovelR1899R0.11
STADchrX71129774SilentNAR1262R0.23
STADchrX71128309Missense_MutationNAA1075T0.35
STADchrX71136460Silentrs747836622R1735R0.17
UCECchrX71128655Missense_MutationNAR1138G0.5
UCECchrX71128348SilentNAL1088L0.15
UCECchrX71126440Nonsense_MutationNAE881*0.4
UCECchrX71136893SilentNAG1805G0.05
UCECchrX71125698Missense_MutationnovelD803Y0.04
UCECchrX71128066Missense_MutationNAS1052I0.38
UCECchrX71137914SilentNAT2005T0.27
UCECchrX71118821Missense_MutationNAD23Y0.47
UCECchrX71121152Missense_MutationnovelQ245H0.11
UCECchrX71121575Missense_MutationnovelF287C0.38
UCECchrX71132190Missense_MutationnovelT1413A0.09
UCECchrX71137267SilentnovelL1878L0.31
UCECchrX71134404Silentrs375001801T1555T0.46
UCECchrX71119718Missense_MutationNAE79D0.31
UCECchrX71119827Missense_MutationNAW116R0.35
UCECchrX71124841Missense_MutationNAF684L0.33
UCECchrX71123171Missense_MutationNAR521H0.25
UCECchrX71123174Missense_MutationnovelA522D0.46
UCECchrX71124829Missense_MutationnovelE680D0.08
UCECchrX71125109Missense_MutationnovelR730Q0.4
UCECchrX71128428SilentnovelL1114L0.07
UCECchrX71136878Splice_SitenovelX1801_splice0.5
UCECchrX71137817Missense_MutationnovelY1973C0.19
UCECchrX711422363'UTRnovel0.4
UCECchrX71137362SilentnovelQ1909Q0.27
UCECchrX71132114Silentrs776947543I1387I0.73
UCECchrX71141228Splice_SitenovelX2093_splice0.35
UCECchrX71130117Missense_MutationNAA1317V0.32
UCECchrX71123164Missense_MutationNAR519W0.46
UCECchrX71124841SilentNAF684F0.42
UCECchrX71124193Missense_MutationnovelF593L0.55
UCECchrX71127098Missense_MutationnovelL939I0.4
UCECchrX71129207Missense_MutationnovelS1190Y0.36
UCECchrX71140736Missense_MutationnovelP2049H0.11
UCECchrX71141305Nonsense_MutationnovelQ2115*0.39
UCECchrX71135202Silentrs376179450I1658I0.19
UCECchrX71120031Missense_MutationnovelK138N0.22
UCECchrX71122599Missense_MutationnovelA447V0.4
UCECchrX71136507Missense_Mutationrs748064846P1751L0.55
UCECchrX71128416Missense_MutationnovelF1110L0.18
UCECchrX71119752Missense_MutationnovelR91C0.07
UCECchrX71126987Missense_MutationNAV902I0.22
UCECchrX71127996Missense_MutationNAP1029S0.12
UCECchrX71132508Missense_MutationNAR1462H0.53
UCECchrX71120127SilentNAI170I0.14
UCECchrX71125068Missense_MutationNAE716D0.12
UCECchrX71129811Missense_MutationNAL1275M0.33
UCECchrX71137329SilentNAY1898Y0.2
UCECchrX71140717Missense_MutationnovelR2043C0.09
UCECchrX71119478Splice_SitenovelX68_splice0.35
UCECchrX71134747Missense_Mutationrs767396596V1588M0.3
UCECchrX71119700In_Frame_DelnovelS74_R82del0.08
UCECchrX71128030Missense_MutationnovelG1040V0.21
UCECchrX71129374SilentnovelQ1212Q0.18
UCECchrX71133201Missense_MutationnovelR1536W0.11
UCECchrX71135195Missense_MutationnovelS1656Y0.16
UCECchrX71137003Missense_MutationnovelY1842C0.17
UCECchrX71137780Missense_MutationnovelG1961S0.1
UCECchrX71134791Silentrs755218771S1602S0.49
UCECchrX71141950Missense_MutationnovelQ2159P0.5
UCECchrX71126150Missense_MutationnovelA846V0.06
UCECchrX71142174Splice_SitenovelX2164_splice0.32
UCECchrX71121008SilentNAQ197Q0.31
UCECchrX71122337SilentNAF413F0.42
UCECchrX71126077Missense_MutationNAA822T0.14
UCECchrX71127124SilentNAV947V0.4
UCECchrX71128354Missense_MutationNAA1090T0.44
UCECchrX71129187Silentrs756037504P1183P0.41
UCECchrX71129688Missense_MutationNAE1234K0.14
UCECchrX71131559Missense_MutationNAQ1353K0.38
UCECchrX71137632SilentNAS1941S0.44
UCECchrX71126993Missense_MutationNAE904K0.38
UCECchrX71125060Missense_MutationnovelP714S0.24
UCECchrX71119857Missense_MutationnovelL126I0.38
UCECchrX71121764Missense_MutationnovelL350R0.4
UCECchrX71124338Missense_MutationNAD642N0.39
UCECchrX71126039Missense_MutationnovelG809E0.23
UCECchrX71129411Missense_MutationnovelK1225E0.1
UCECchrX71136294Missense_MutationnovelS1680Y0.31
UCECchrX71136940Missense_MutationnovelL1821P0.4
UCECchrX711423253'UTRnovel0.29
UCECchrX71123171Missense_MutationNAR521H0.21
UCECchrX71122297Missense_MutationnovelA400V0.29
UCECchrX71124332Missense_MutationNAP640S0.32
UCECchrX71126056Missense_MutationNAR815W0.5
UCECchrX71119861Missense_Mutationrs775072642T127M0.31
UCECchrX71124263Missense_Mutationrs765417606T617A0.2
UCECchrX71121029Nonsense_MutationnovelY204*0.19
UCECchrX71121615Missense_MutationnovelF300L0.36
UCECchrX71130083Missense_MutationnovelD1306Y0.11
UCECchrX71132513Nonsense_MutationnovelE1464*0.35
UCECchrX71135247SilentnovelK1673K0.36
UCECchrX71126435Missense_MutationnovelL879R0.46
UCECchrX71129731Missense_MutationnovelE1248V0.24
UCECchrX71137346Missense_Mutationrs200663107A1904V0.15
UCECchrX71141265SilentnovelQ2101Q0.27
UCECchrX71119693Missense_MutationnovelS71F0.37
UCECchrX71122836Nonsense_MutationnovelR483*0.43
UCECchrX71134816Missense_MutationnovelR1611C0.33
UCECchrX71136377Missense_MutationnovelV1708F0.16
UCECchrX71123635Silentrs763388314I553I0.42
UCECchrX71122531SilentNAI424I0.5
UCECchrX71127957Missense_MutationnovelR1016C0.62
UCECchrX71136307Missense_MutationnovelK1684N0.47
UCECchrX71119383Missense_MutationnovelT37M0.43
UCECchrX71128685Missense_MutationnovelR1148C0.49
UCECchrX71132522Nonsense_MutationnovelR1467*0.36
UCECchrX71137792Frame_Shift_DelnovelS1967Afs*190.22
UCECchrX71131595Missense_MutationnovelL1365F0.6
UCECchrX71129691SilentNAL1235L0.33
UCECchrX71120985Missense_Mutationrs374780236I190V0.12
UCECchrX71132178Missense_MutationNAS1409G0.07
UCECchrX71128655Missense_MutationNAR1138W0.44
UCECchrX71122837Missense_MutationNAR483Q0.39
UCECchrX711423983'UTRnovel0.49
UCECchrX71129194Missense_MutationnovelN1186D0.16
UCECchrX71123170Missense_MutationNAR521C0.49
UCECchrX71118795Missense_MutationnovelL14R0.1
UCECchrX71118796SilentnovelL14L0.1
UCECchrX71133159Missense_MutationnovelD1522N0.39
UCECchrX71121408Missense_MutationnovelL273I0.15
UCECchrX71128025SilentnovelG1038G0.17
UCECchrX71134450Missense_MutationnovelD1571N0.39
UCECchrX71135250Missense_MutationnovelK1674N0.13
UCECchrX71123170Missense_MutationNAR521C0.21
UCECchrX71124223SilentnovelL603L0.39
UCECchrX71126378Missense_MutationnovelA860V0.43
UCECchrX71127333Splice_Regionnovel0.24
UCECchrX71136419Missense_MutationnovelR1722W0.31
UCECchrX71137871Missense_MutationnovelL1991P0.18
UCECchrX71123192Missense_MutationnovelL528H0.13
UCECchrX71132892Missense_MutationNAC1488Y0.22
UCECchrX71119702In_Frame_DelnovelS75_C83del0.15
UCECchrX71126100SilentnovelI829I0.45
UCECchrX71127444Missense_MutationnovelK986N0.26
UCECchrX71134796Missense_MutationnovelG1604D0.38
UCECchrX71129378Missense_MutationnovelR1214S0.3
UCECchrX71127938SilentnovelE1009E0.28
UCECchrX71128685Missense_MutationnovelR1148C0.28
UCECchrX71136629Missense_MutationnovelR1792C0.4
UCECchrX71137370Missense_Mutationrs767294730R1912H0.36
UCECchrX71120133Missense_MutationnovelE172D0.37
UCECchrX71121110SilentnovelR231R0.43
UCECchrX71126056Missense_MutationNAR815W0.41
UCECchrX71122271SilentnovelG391G0.44
UCECchrX71121343Missense_MutationnovelR251K0.11
UCECchrX71136284Missense_MutationNAL1677I0.48
UCECchrX71121380Missense_MutationnovelE263D0.06
UCECchrX71127974Missense_Mutationrs797045698F1021L0.35
UCECchrX71125041Missense_MutationnovelE707D0.14
UCECchrX711424243'UTRnovel0.13
UCECchrX71123226Missense_MutationNAE539D0.25
UCECchrX71121639Missense_MutationnovelQ308H0.3
UCECchrX71125068Missense_MutationNAE716D0.23
UCECchrX71141940Missense_MutationnovelR2156W0.2
UCECchrX71141913Nonsense_MutationnovelQ2147*0.33
UCECchrX71132907Missense_MutationnovelD1493G0.23
UCECchrX71123626SilentNAK550K0.15
UCECchrX71141242In_Frame_DelnovelQ2113_Q2115del0.23
UCECchrX71126090Missense_MutationnovelA826V0.31
UCECchrX71136461Missense_MutationnovelA1736T0.12
UCECchrX71118821Missense_MutationNAD23Y0.58
UCECchrX71136942Missense_MutationnovelH1822Y0.14
UCECchrX71127966Missense_MutationnovelP1019S0.22
UCECchrX71132956Missense_MutationnovelQ1509H0.28
UCECchrX71127101Frame_Shift_DelnovelN940Tfs*160.13
UCECchrX71132906Missense_MutationnovelD1493N0.28
UCECchrX71123690Nonsense_MutationnovelQ572*0.41
UCECchrX71125400Missense_MutationNAG759V0.46
UCECchrX71140701Silentrs370522888G2037G0.24
UCECchrX71119718Missense_MutationNAE79D0.44
UCECchrX71122571Missense_Mutationrs771266719R438C0.49
UCECchrX71124841Missense_MutationNAF684L0.42
UCECchrX71119478Splice_SitenovelX68_splice0.62
UCECchrX71125426Missense_MutationnovelR768C0.38
UCECchrX71123171Missense_MutationNAR521H0.4
UCECchrX71141269In_Frame_DelnovelQ2115del0.12
UCECchrX71118806Missense_MutationNAR18W0.44
UCECchrX71119718Missense_MutationNAE79D0.4
UCECchrX71124168Missense_Mutationrs747113641R585Q0.31
UCECchrX71130152Nonsense_MutationNAR1329*0.22
UCECchrX71136535Missense_MutationNAE1760D0.23
UCECchrX71125440SilentnovelK772K0.34
UCECchrX71142193Missense_MutationnovelS2170N0.3
UCECchrX71129818Missense_MutationNAV1277A0.3
UCECchrX71121084Missense_MutationnovelP223S0.7
UCECchrX71129408Missense_MutationnovelL1224I0.23
UCECchrX71133120Splice_Regionnovel0.1
UCECchrX71129785Missense_Mutationrs587780391R1266H0.41
UCECchrX71135107Missense_Mutationrs776748297R1627C0.16
UCECchrX71123171Missense_MutationNAR521H0.41
UCECchrX71134816Missense_MutationnovelR1611C0.07
UCECchrX71137320SilentnovelT1895T0.08
UCECchrX71137614SilentNAS1935S0.31
UCECchrX71129785Missense_Mutationrs587780391R1266H0.32
UCECchrX71125122SilentNAY734Y0.4
UCECchrX71120158Missense_MutationnovelD181Y0.38
UCECchrX71124182Missense_MutationnovelR590W0.41
UCECchrX71118819Missense_MutationNAP22R0.3
UCECchrX71121596Missense_MutationnovelS294Y0.44
UCECchrX711423773'UTRnovel0.25
UCSchrX71130201Missense_MutationnovelK1345T0.22
UCSchrX71137019SilentnovelP1847P0.41
UCSchrX71118821Missense_MutationNAD23Y0.39
UCSchrX71124249Missense_MutationnovelN612T0.39
UCSchrX71132513Nonsense_MutationnovelE1464*0.37
UCSchrX71124182Missense_MutationnovelR590W0.43
UVMchrX71119761Missense_MutationnovelP94S1

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCAAMP0.06860.0018563
GBMDEL0.03293.2518e-06
KIRCAMP0.02082.0306e-05
KIRPAMP0.09030.15981
LUADDEL0.08330.010111
PAADAMP0.0380.16151
SARCDEL0.24120.0086757
TGCTAMP0.08677.0307e-05
THCADEL00.21991

Survival Analysis
CancerP-value Q-value
SARC0.038

Kaplan-Meier Survival Analysis

KIRP0.035

Kaplan-Meier Survival Analysis

KICH0.018

Kaplan-Meier Survival Analysis

GBM0.033

Kaplan-Meier Survival Analysis

LUAD0.033

Kaplan-Meier Survival Analysis

UVM0.048

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000184634 (Gene tree)
Gene ID
9968
Gene Symbol
MED12
Alias
CAGH45|HOPA|OPA1|TRAP230|KIAA0192|OKS|TNRC11|FGS1
Full Name
mediator complex subunit 12
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
23,899 bases
Position
chrX:71,118,556-71,142,454
Accession
11957
RBP type
non-canonical RBP
Summary
The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
30456381CARM1 methylates MED12 to regulate its RNA-binding ability.Life Sci Alliance2018 Sep 19Cheng Ddoi: 10.26508/lsa.201800117
16712834Zebrafish Trap230/Med12 is required as a coactivator for Sox9-dependent neural crest, cartilage and ear development.Dev Biol2006 Aug 1Rau MJ-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000374080MED12-2026795-ENSP000003631932177 (aa)-Q93074
ENST00000460771MED12-206330--- (aa)--
ENST00000471663MED12-208439--- (aa)--
ENST00000489199MED12-209349--- (aa)--
ENST00000462984MED12-207631--- (aa)--
ENST00000429213MED12-204389-ENSP00000399084130 (aa)-H7C191
ENST00000374102MED12-2036827-ENSP000003632152176 (aa)-Q93074
ENST00000333646MED12-2016977-ENSP000003331252027 (aa)-Q7Z3Z5
ENST00000444034MED12-205752-ENSP00000404373251 (aa)-H7C274
Gene Model
Click here to download ENSG00000184634's gene model file
Pathways
Pathway IDPathway NameSource
hsa04919Thyroid hormone signaling pathwayKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000184634's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000151ubiquitin ligase complex-IEAComponent
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding-IEAFunction
GO:0001843neural tube closure-IEAProcess
GO:0003682chromatin binding-IEAFunction
GO:0003712transcription coregulator activity10198638.12218053.IDAFunction
GO:0003713transcription coactivator activity21873635.IBAFunction
GO:0003713transcription coactivator activity12037571.IDAFunction
GO:0005515protein binding21293490.23178117.26496610.IPIFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus10235267.17000779.IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0006357regulation of transcription by RNA polymerase II21873635.IBAProcess
GO:0006367transcription initiation from RNA polymerase II promoter12218053.IDAProcess
GO:0006367transcription initiation from RNA polymerase II promoter-TASProcess
GO:0007492endoderm development-IEAProcess
GO:0007507heart development-IEAProcess
GO:0008013beta-catenin binding-IEAFunction
GO:0008022protein C-terminus binding17000779.IPIFunction
GO:0014003oligodendrocyte development-IEAProcess
GO:0014044Schwann cell development-IEAProcess
GO:0016020membrane19946888.HDAComponent
GO:0016567protein ubiquitination-IEAProcess
GO:0016592mediator complex21873635.IBAComponent
GO:0016592mediator complex10198638.12037571.IDAComponent
GO:0019827stem cell population maintenance-IEAProcess
GO:0019904protein domain specific binding11984006.IPIFunction
GO:0021510spinal cord development-IEAProcess
GO:0030374nuclear receptor transcription coactivator activity10235266.NASFunction
GO:0036342post-anal tail morphogenesis-IEAProcess
GO:0042809vitamin D receptor binding10235266.NASFunction
GO:0045893positive regulation of transcription, DNA-templated10198638.IDAProcess
GO:0045944positive regulation of transcription by RNA polymerase II12037571.IDAProcess
GO:0046966thyroid hormone receptor binding10198638.IDAFunction
GO:0048702embryonic neurocranium morphogenesis-IEAProcess
GO:0060070canonical Wnt signaling pathway-IEAProcess
GO:0060071Wnt signaling pathway, planar cell polarity pathway-IEAProcess
GO:0061630ubiquitin protein ligase activity-IEAFunction
GO:0090245axis elongation involved in somitogenesis-IEAProcess
GO:1990403embryonic brain development-IEAProcess
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