EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
18388483	Role of CAGE, a novel cancer/testis antigen, in various cellular processes, including tumorigenesis, cytolytic T lymphocyte induction, and cell motility.	J Microbiol Biotechnol	2008 Mar	Kim Y	-
28152297	DDX53 Promotes Cancer Stem Cell-Like Properties and Autophagy.	Mol Cells	2017 Jan	Kim H	doi: 10.14348/molcells.2017.2258
26883907	Histone Deacetylase-3/CAGE Axis Targets EGFR Signaling and Regulates the Response to Anti-Cancer Drugs.	Mol Cells	2016 Mar	Kim H	doi: 10.14348/molcells.2016.2244
17028776	Cancer/testis antigen cancer-associated gene (CAGE) promotes motility of cancer cells through activation of focal adhesion kinase (FAK).	Biotechnol Lett	2006 Dec	Shim H	-
26863629	miR-217 and CAGE form feedback loop and regulates the response to anti-cancer drugs through EGFR and HER2.	Oncotarget	2016 Mar 1	Kim Y	doi: 10.18632/oncotarget.7185.
26912082	miR-30a Regulates the Expression of CAGE and p53 and Regulates the Response to Anti-Cancer Drugs.	Mol Cells	2016 Apr 30	Park D	doi: 10.14348/molcells.2016.2242
12849980	Promoter hypomethylation of a novel cancer/testis antigen gene CAGE is correlated with its aberrant expression and is seen in premalignant stage of gastric carcinoma.	Biochem Biophys Res Commun	2003 Jul 18	Cho B	-
28535666	DDX53 Regulates Cancer Stem Cell-Like Properties by Binding to SOX-2.	Mol Cells	2017 May 31	Kim Y	doi: 10.14348/molcells.2017.0001

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chrX	23000733	Missense_Mutation	NA	A226T	0.29
ACC	chrX	23000983	Missense_Mutation	novel	A309D	0.23	KH_1
BLCA	chrX	23000955	Missense_Mutation	NA	L300I	0.07	KH_1
BLCA	chrX	23001405	Missense_Mutation	NA	E450Q	0.06
BLCA	chrX	23001181	Missense_Mutation	novel	I375T	0.15	KH_1
BRCA	chrX	23000541	Missense_Mutation	NA	E162K	0.19
BRCA	chrX	23001656	Silent	novel	L533L	0.1
BRCA	chrX	23001249	Missense_Mutation	rs769123385	R398C	0.24	KH_1
BRCA	chrX	23000611	Missense_Mutation	novel	T185I	0.06
BRCA	chrX	23000208	Missense_Mutation	novel	L51F	0.07
BRCA	chrX	23001701	Silent	NA	I548I	0.16
BRCA	chrX	23001637	Missense_Mutation	NA	V527G	0.44
BRCA	chrX	23000078	Missense_Mutation	novel	E7D	0.1
BRCA	chrX	23000537	Silent	rs749049454	V160V	0.08
CESC	chrX	23001045	Missense_Mutation	NA	Y330H	0.4	KH_1
CESC	chrX	23001041	Silent	rs748256605	C328C	0.26
CESC	chrX	23001405	Missense_Mutation	NA	E450Q	0.41
COAD	chrX	23000287	Missense_Mutation	NA	S77L	0.38
COAD	chrX	23000589	Missense_Mutation	novel	F178V	0.06
COAD	chrX	23001512	Silent	rs373240695	S485S	0.18
COAD	chrX	23001250	Missense_Mutation	rs368434907	R398H	0.07	KH_1
COAD	chrX	23001964	3'UTR	novel		0.45
COAD	chrX	23000315	Silent	rs778444531	N86N	0.1
COAD	chrX	23001830	Silent	NA	Q591Q	0.31
COAD	chrX	23001579	Silent	NA	R508R	0.15
COAD	chrX	23000304	Missense_Mutation	NA	Q83E	0.22
COAD	chrX	23000089	Missense_Mutation	NA	A11V	0.14
COAD	chrX	23000271	Missense_Mutation	novel	K72E	0.07
COAD	chrX	23001351	Missense_Mutation	NA	N432D	0.54
GBM	chrX	23001603	Missense_Mutation	rs751629687	G516R	0.06
GBM	chrX	23000475	Frame_Shift_Ins	novel	*R140Mfs3**	0.04
GBM	chrX	23001335	Missense_Mutation	NA	M426I	0.27
HNSC	chrX	23000681	Missense_Mutation	novel	L208F	0.55
HNSC	chrX	23001694	Missense_Mutation	novel	R546K	0.43
HNSC	chrX	23001220	Missense_Mutation	novel	P388L	0.49	KH_1
HNSC	chrX	23000994	Nonsense_Mutation	novel	E313*	0.35	KH_1
KIRC	chrX	23001704	Silent	rs768020057	D549D	0.16
KIRC	chrX	23001982	3'UTR	novel		0.12
KIRP	chrX	23000991	Missense_Mutation	rs756147094	V312M	0.56	KH_1
LAML	chrX	23000179	Missense_Mutation	NA	P41L	0.4
LGG	chrX	23000165	Silent	novel	F36F	0.34
LIHC	chrX	23000315	Silent	rs778444531	N86N	0.8
LIHC	chrX	23002018	3'UTR	novel		0.89
LIHC	chrX	23001455	Silent	novel	P466P	0.05
LIHC	chrX	23001510	Missense_Mutation	NA	S485G	0.92
LUAD	chrX	23001895	Missense_Mutation	NA	R613I	0.35
LUAD	chrX	23001593	Silent	NA	D512D	0.33
LUAD	chrX	23000255	Nonsense_Mutation	novel	Y66*	0.11
LUAD	chrX	23000206	Missense_Mutation	NA	P50Q	0.41
LUAD	chrX	23000947	Missense_Mutation	NA	P297H	0.34	KH_1
LUAD	chrX	23001306	Missense_Mutation	novel	L417I	0.2
LUAD	chrX	23001643	Missense_Mutation	NA	R529Q	0.05
LUAD	chrX	23001356	Silent	NA	L433L	0.36
LUAD	chrX	23000419	Nonsense_Mutation	novel	S121*	0.21
LUAD	chrX	23000411	Silent	NA	S118S	0.32
LUSC	chrX	23001576	Missense_Mutation	novel	E507K	0.69
LUSC	chrX	23001271	Missense_Mutation	novel	M405K	0.36	KH_1
LUSC	chrX	23001052	Missense_Mutation	novel	G332V	0.59	KH_1
LUSC	chrX	23000314	Missense_Mutation	NA	N86S	0.28
LUSC	chrX	23000270	Missense_Mutation	NA	I71M	0.09
LUSC	chrX	23000551	Missense_Mutation	NA	K165R	0.24
LUSC	chrX	23001861	Missense_Mutation	NA	E602K	0.36
LUSC	chrX	23001420	Missense_Mutation	novel	A455T	0.1
LUSC	chrX	23001815	Silent	NA	L586L	0.18
LUSC	chrX	23001854	Silent	NA	V599V	0.23
LUSC	chrX	23000421	Missense_Mutation	NA	E122Q	0.08
LUSC	chrX	23001784	Missense_Mutation	NA	S576L	0.58
LUSC	chrX	23000414	Nonsense_Mutation	novel	Y119*	0.33
LUSC	chrX	23000554	Missense_Mutation	novel	R166I	0.45
LUSC	chrX	23000951	Silent	NA	G298G	0.4
OV	chrX	23000512	Frame_Shift_Ins	novel	*N152Kfs6**	0.09
OV	chrX	23000991	Missense_Mutation	rs756147094	V312M	0.64	KH_1
OV	chrX	23001585	Missense_Mutation	novel	V510L	0.09
OV	chrX	23000850	Missense_Mutation	novel	V265F	0.1	KH_1
OV	chrX	23000449	Missense_Mutation	novel	Q131P	0.11
PAAD	chrX	23001942	Missense_Mutation	novel	F629V	0.2
READ	chrX	23001785	Silent	rs768469586	S576S	0.47
READ	chrX	23000586	Frame_Shift_Ins	NA	*N177Ifs14**	0.28
READ	chrX	23001078	Missense_Mutation	novel	D341Y	0.07	KH_1
SARC	chrX	23002080	3'UTR	novel		0.06
SKCM	chrX	23000380	Missense_Mutation	NA	A108G	0.13
SKCM	chrX	23001055	Missense_Mutation	rs778044990	R333K	0.11	KH_1
SKCM	chrX	23000112	Missense_Mutation	NA	G19R	0.38
SKCM	chrX	23000960	Silent	novel	V301V	0.33
SKCM	chrX	23001650	Silent	NA	L531L	0.23
SKCM	chrX	23000358	Missense_Mutation	NA	M101L	0.58
SKCM	chrX	23000916	Nonsense_Mutation	NA	Q287*	0.51	KH_1
SKCM	chrX	23001640	Missense_Mutation	NA	S528F	0.56
SKCM	chrX	23001933	Missense_Mutation	NA	E626K	0.52
SKCM	chrX	23000196	Missense_Mutation	NA	R47C	0.34
SKCM	chrX	23001784	Missense_Mutation	NA	S576L	0.19
SKCM	chrX	23000355	Missense_Mutation	NA	E100K	0.29
SKCM	chrX	23000652	Missense_Mutation	NA	E199K	0.3
SKCM	chrX	23001784	Missense_Mutation	NA	S576L	0.62
SKCM	chrX	23000652	Missense_Mutation	NA	E199K	0.32
SKCM	chrX	23000195	Silent	NA	S46S	0.88
SKCM	chrX	23000467	Missense_Mutation	NA	N137I	0.8
SKCM	chrX	23000360	Missense_Mutation	NA	M101I	0.11
SKCM	chrX	23001695	Silent	novel	R546R	0.81
SKCM	chrX	23000775	Missense_Mutation	NA	V240I	0.53
SKCM	chrX	23000410	Missense_Mutation	rs760082872	S118N	0.54
SKCM	chrX	23001221	Silent	NA	P388P	0.83
SKCM	chrX	23001101	Silent	rs529875384	I348I	0.4
SKCM	chrX	23001067	Missense_Mutation	rs368652147	G337E	0.92	KH_1
SKCM	chrX	23000175	Missense_Mutation	novel	G40R	0.9
STAD	chrX	23000662	Missense_Mutation	NA	N202S	0.39
STAD	chrX	23001513	Missense_Mutation	rs149709546	D486N	0.68
STAD	chrX	23000410	Missense_Mutation	rs760082872	S118N	0.09
STAD	chrX	23001872	Missense_Mutation	NA	K605N	0.09
STAD	chrX	23000089	Missense_Mutation	NA	A11V	0.22
STAD	chrX	23000303	Missense_Mutation	NA	I82M	0.45
STAD	chrX	23000157	Missense_Mutation	novel	G34C	0.58
UCEC	chrX	23001794	Silent	novel	A579A	0.69
UCEC	chrX	23001801	Missense_Mutation	NA	L582M	0.43
UCEC	chrX	23000501	Missense_Mutation	NA	E148D	0.28
UCEC	chrX	23000874	Missense_Mutation	NA	T273A	0.25	KH_1
UCEC	chrX	23001712	Missense_Mutation	novel	V552A	0.08
UCEC	chrX	23001923	Missense_Mutation	novel	Q622H	0.21
UCEC	chrX	23000227	Missense_Mutation	NA	N57S	0.3
UCEC	chrX	23001654	Missense_Mutation	NA	L533F	0.36
UCEC	chrX	23000662	Missense_Mutation	NA	N202S	0.37
UCEC	chrX	23001300	Missense_Mutation	rs754046377	R415C	0.48	KH_1
UCEC	chrX	23000131	Missense_Mutation	rs754998919	R25M	0.1
UCEC	chrX	23001320	Nonsense_Mutation	novel	Y421*	0.33
UCEC	chrX	23000180	Silent	NA	P41P	0.33
UCEC	chrX	23000142	Missense_Mutation	novel	G29C	0.43
UCEC	chrX	23000914	Missense_Mutation	NA	S286F	0.38	KH_1
UCEC	chrX	23000894	Frame_Shift_Ins	novel	*G280Rfs11**	0.12	KH_1
UCEC	chrX	23001563	Silent	NA	E502E	0.17
UCEC	chrX	23000377	Missense_Mutation	NA	A107V	0.39
UCEC	chrX	23000904	Frame_Shift_Ins	novel	*H283Pfs19**	0.05	KH_1
UCEC	chrX	23000012	5'UTR	novel		0.22
UCEC	chrX	23000174	Missense_Mutation	novel	Q39H	0.08
UCEC	chrX	23001995	3'UTR	novel		0.3
UCEC	chrX	23000031	5'UTR	novel		0.33
UCEC	chrX	23001704	Silent	rs768020057	D549D	0.45
UCEC	chrX	23000862	Missense_Mutation	novel	G269R	0.38	KH_1
UCEC	chrX	23000476	Missense_Mutation	novel	R140I	0.48
UCEC	chrX	23000841	Missense_Mutation	novel	L262I	0.43	KH_1
UCEC	chrX	23000546	Silent	rs200945232	C163C	0.2
UCEC	chrX	23001299	Silent	novel	V414V	0.27
UCEC	chrX	23001124	Missense_Mutation	novel	L356P	0.35	KH_1
UCEC	chrX	23000091	Nonsense_Mutation	novel	E12*	0.4
UCEC	chrX	23000223	Missense_Mutation	novel	K56Q	0.09
UCEC	chrX	23001746	Missense_Mutation	novel	K563N	0.27
UCEC	chrX	23000811	Missense_Mutation	rs371119636	A252T	0.41	KH_1
UCEC	chrX	22999981	5'UTR	NA		0.1
UCEC	chrX	23000378	Silent	NA	A107A	0.39
UCEC	chrX	23000844	Missense_Mutation	novel	I263L	0.58	KH_1
UCEC	chrX	23000288	Silent	rs759217097	S77S	0.32
UCEC	chrX	23001386	Silent	novel	Q443Q	0.1
UCEC	chrX	23002048	3'UTR	novel		0.34
UCEC	chrX	23001819	Missense_Mutation	novel	R588G	0.34
UCEC	chrX	23000520	Missense_Mutation	novel	R155C	0.13
UCEC	chrX	23000737	Missense_Mutation	novel	F227C	0.13
UCEC	chrX	23001016	Nonsense_Mutation	novel	S320*	0.21	KH_1
UCEC	chrX	23001602	Silent	novel	S515S	0.41
UCEC	chrX	23001883	Frame_Shift_Del	novel	*K610Efs41**	0.2
UCEC	chrX	23001195	Missense_Mutation	novel	K380Q	0.21	KH_1
UCEC	chrX	23001603	Missense_Mutation	rs751629687	G516R	0.21
UCEC	chrX	23001705	Missense_Mutation	rs374604625	V550I	0.15
UCEC	chrX	23000537	Silent	rs749049454	V160V	0.47
UCEC	chrX	23000089	Missense_Mutation	NA	A11V	0.28
UCEC	chrX	23000667	Missense_Mutation	novel	T204P	0.32
UCEC	chrX	23001400	Missense_Mutation	novel	T448I	0.04
UCEC	chrX	23000089	Missense_Mutation	NA	A11V	0.36
UCEC	chrX	23000131	Frame_Shift_Del	novel	*G26Afs30**	0.08
UCEC	chrX	23000742	Nonsense_Mutation	NA	Q229*	0.41
UCEC	chrX	23000666	Missense_Mutation	novel	I203M	0.39
UCEC	chrX	23000907	Missense_Mutation	NA	L284I	0.39	KH_1
UCEC	chrX	23001866	Missense_Mutation	NA	Q603H	0.43
UCEC	chrX	23000287	Missense_Mutation	NA	S77L	0.34
UCEC	chrX	23000314	Missense_Mutation	NA	N86S	0.36
UCEC	chrX	23000546	Silent	rs200945232	C163C	0.3
UCEC	chrX	23000184	Missense_Mutation	novel	A43T	0.08
UCEC	chrX	23000504	Silent	novel	P149P	0.47
UCEC	chrX	23002082	3'UTR	novel		0.3

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
READ	AMP	0.103	0.13718
SARC	AMP	0.3074	0.19108
THCA	DEL	0.002	0.21991

Survival Analysis

Cancer	P-value	Q-value
		Kaplan-Meier Survival Analysis

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000184735 (Gene tree)
Gene ID: 168400
Gene Symbol: DDX53
Alias: CAGE|CT26
Full Name: DEAD-box helicase 53
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 3,629 bases
Position: chrX:22,999,961-23,003,589
Accession: 20083
RBP type: canonical RBP
Summary: This intronless gene encodes a protein which contains several domains found in members of the DEAD-box helicase protein family. Other members of this protein family participate in ATP-dependent RNA unwinding. [provided by RefSeq, Sep 2011]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000368667	KH_1	PF00013.29	7.4e-11	1	1
ENSP00000368667	DEAD	PF00270.29	1.4e-42	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
19549529	Cyclooxygenase-2 inhibitors down-regulate osteopontin and Nr4A2-new therapeutic targets for colorectal cancers.	Gastroenterology	2009 Oct	Zagani R	doi: 10.1053/j.gastro.2009.06.039

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000327968	DDX53-201	3629	-	ENSP00000368667	631 (aa)	-	Q86TM3

Gene Model

Click here to download ENSG00000184735's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000184735's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000184735	DDX53	71	35.320	ENSG00000198231	DDX42	62	35.320
ENSG00000184735	DDX53	55	31.638	ENSG00000088205	DDX18	52	31.638
ENSG00000184735	DDX53	61	35.427	ENSG00000183258	DDX41	80	34.965
ENSG00000184735	DDX53	69	43.018	ENSG00000108654	DDX5	98	53.374
ENSG00000184735	DDX53	55	31.034	ENSG00000141543	EIF4A3	83	31.034
ENSG00000184735	DDX53	60	34.715	ENSG00000124228	DDX27	87	33.469
ENSG00000184735	DDX53	57	32.065	ENSG00000165732	DDX21	51	32.065
ENSG00000184735	DDX53	60	35.859	ENSG00000067048	DDX3Y	60	35.859
ENSG00000184735	DDX53	54	33.523	ENSG00000105671	DDX49	71	33.523
ENSG00000184735	DDX53	59	33.766	ENSG00000118197	DDX59	97	36.486
ENSG00000184735	DDX53	51	30.247	ENSG00000156976	EIF4A2	88	30.247
ENSG00000184735	DDX53	66	32.477	ENSG00000278053	DDX52	72	32.207
ENSG00000184735	DDX53	62	34.091	ENSG00000213782	DDX47	85	34.091
ENSG00000184735	DDX53	55	32.081	ENSG00000110367	DDX6	70	32.081
ENSG00000184735	DDX53	70	43.596	ENSG00000100201	DDX17	60	43.333
ENSG00000184735	DDX53	54	33.429	ENSG00000123064	DDX54	95	37.745
ENSG00000184735	DDX53	65	37.838	ENSG00000174243	DDX23	53	42.683
ENSG00000184735	DDX53	99	61.821	ENSG00000080007	DDX43	96	61.821
ENSG00000184735	DDX53	57	37.366	ENSG00000152670	DDX4	64	37.366
ENSG00000184735	DDX53	60	36.364	ENSG00000215301	DDX3X	83	36.364

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000184735	DDX53	99	82.006	ENSCCAG00000021534	-	100	82.006	Cebus_capucinus
ENSG00000184735	DDX53	99	82.006	ENSCCAG00000024171	-	100	82.006	Cebus_capucinus
ENSG00000184735	DDX53	99	89.984	ENSCSAG00000019540	DDX53	99	89.984	Chlorocebus_sabaeus
ENSG00000184735	DDX53	100	96.830	ENSPPAG00000006869	DDX53	100	96.830	Pan_paniscus
ENSG00000184735	DDX53	100	96.513	ENSPTRG00000028313	DDX53	100	96.513	Pan_troglodytes
ENSG00000184735	DDX53	99	94.913	ENSPPYG00000020185	DDX53	100	94.913	Pongo_abelii

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	-	IEA	Function
GO:0004386	helicase activity	-	IEA	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	-	IEA	Component

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.