EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
24633336P53, hTERT, WT-1, and VEGFR2 are the most suitable targets for cancer vaccine therapy in HLA-A24 positive pancreatic adenocarcinoma.Cancer Immunol Immunother2014 MayTerashima Tdoi: 10.1007/s00262-014-1529-8
27062662Wilms' tumor 1 protein expression in endometrial adenocarcinoma and endometrial intra-epithelial neoplasia.J Obstet Gynaecol Res2016 JulAtik Ydoi: 10.1111/jog.12981
25932444Risk-Reducing Genetic Variant of Wilms Tumor 1 Gene rs16754 in Korean Patients With BCR-ABL1-Negative Myeloproliferative Neoplasm.Ann Lab Med2015 MayKim Ndoi: 10.3343/alm.2015.35.3.348
25932436Incidences and Prognostic Impact of c-KIT, WT1, CEBPA, and CBL Mutations, and Mutations Associated With Epigenetic Modification in Core Binding Factor Acute Myeloid Leukemia: A Multicenter Study in a Korean Population.Ann Lab Med2015 MayPark SHdoi: 10.3343/alm.2015.35.3.288
26320177WT1-mediated repression of the proapoptotic transcription factor ZNF224 is triggered by the BCR-ABL oncogene.Oncotarget2015 Sep 29Montano Gdoi: 10.18632/oncotarget.4950.
23874238Disease-related growth factor and embryonic signaling pathways modulate an enhancer of TCF21 expression at the 6q23.2 coronary heart disease locus.PLoS Genet2013Miller CLdoi: 10.1371/journal.pgen.1003652
19250757Expression of Wilms tumor-1 protein and CD 138 in malignant mesothelioma of the tunica vaginalis.Pathol Res Pract2009Al-Salam Sdoi: 10.1016/j.prp.2009.01.012
20435628Prognostic implications of mutations and expression of the Wilms tumor 1 (WT1) gene in adult acute T-lymphoblastic leukemia.Haematologica2010 JunHeesch Sdoi: 10.3324/haematol.2009.016386
21760594Wilms' tumor 1 single-nucleotide polymorphism rs16754 does not predict clinical outcome in adult acute myeloid leukemia.Leukemia2011 DecRenneville Adoi: 10.1038/leu.2011.173
19847202Wilms tumor 1 (WT1) gene mutations in pediatric T-cell malignancies.Leukemia2010 FebRenneville Adoi: 10.1038/leu.2009.221
26597595A 4-gene expression score associated with high levels of Wilms Tumor-1 (WT1) expression is an adverse prognostic factor in acute myeloid leukaemia.Br J Haematol2016 FebNiavarani Adoi: 10.1111/bjh.13836
23706170Coordinate patterns of estrogen receptor, progesterone receptor, and Wilms tumor 1 expression in the histopathologic distinction of ovarian from endometrial serous adenocarcinomas.Ann Diagn Pathol2013 OctFadare Odoi: 10.1016/j.anndiagpath.2013.04.011
20016532Mutant Wilms' tumor 1 (WT1) mRNA with premature termination codons in acute myeloid leukemia (AML) is sensitive to nonsense-mediated RNA decay (NMD).Leukemia2010 MarAbbas Sdoi: 10.1038/leu.2009.265
18516627A novel Wilms' tumor 1 gene mutation in a child with severe renal dysfunction and persistent renal blastema.Pediatr Nephrol2008 SepWagner Ndoi: 10.1007/s00467-008-0845-7
22242671Use of (11)C-methionine PET parametric response map for monitoring WT1 immunotherapy response in recurrent malignant glioma.J Neurosurg2012 AprChiba Ydoi: 10.3171/2011.12.JNS111255
24257751Transcriptional repression of tumor suppressor CDC73, encoding an RNA polymerase II interactor, by Wilms tumor 1 protein (WT1) promotes cell proliferation: implication for cancer therapeutics.J Biol Chem2014 Jan 10Rather MIdoi: 10.1074/jbc.M113.483255
21909685Wilms tumor-1, claudin-1 and ezrin are useful immunohistochemical markers that help to distinguish schwannoma from fibroblastic meningioma.Pathol Oncol Res2012 AprSingh Adoi: 10.1007/s12253-011-9456-x
25447528Wilms' tumor 1 enhances Cisplatin-resistance of advanced NSCLC.FEBS Lett2014 Dec 20Wu Cdoi: 10.1016/j.febslet.2014.10.026
18260155Wilms tumor gene protein 1 is associated with ovarian cancer metastasis and modulates cell invasion.Cancer2008 Apr 1Barbolina MVdoi: 10.1002/cncr.23341.
27354645Immunohistochemical Analysis of WT1 Antigen Expression in Various Solid Cancer Cells.Anticancer Res2016 JulNaitoh K-
22434317Desmoplastic small round cell tumor-clinicopathological spectrum, including unusual features and immunohistochemical analysis of 45 tumors diagnosed at a tertiary cancer referral centre, with molecular results t(11; 22) (p13; q12) (EWS-WT1) in select cases.Pathol Oncol Res2012 OctRekhi B-
24503796Insulin-like growth factor I regulates the expression of isoforms of Wilms' tumor 1 gene in breast cancer.Tumori2013 Nov-DecTuna Mdoi: 10.1700/1390.15461.
18181329Growth inhibition of breast cancer cell line MCF-7 by siRNA silencing of Wilms tumor 1 gene.J Med Assoc Thai2007 NovNavakanit R-
20871039WT1 expression correlates with angiogenesis in endometrial cancer tissue.Anticancer Res2010 AugDohi S-
28677722Regulation of retinoic acid synthetic enzymes by WT1 and HDAC inhibitors in 293 cells.Int J Mol Med2017 SepLi Ydoi: 10.3892/ijmm.2017.3051
18273617Topotecan distribution in an anephric infant with therapy-resistant bilateral Wilms tumor with a novel germline WT1 gene mutation.Cancer Chemother Pharmacol2008 NovLugtenberg RTdoi: 10.1007/s00280-008-0694-x
19749460High frequency of loss of allelic integrity at Wilms' tumor suppressor gene-1 locus in advanced breast tumors associated with aggressiveness of the tumor.Indian J Cancer2009 Oct-DecGupta Sdoi: 10.4103/0019-509X.55550.
18703217A new molecular variant of desmoplastic small round cell tumor: significance of WT1 immunostaining in this entity.Hum Pathol2008 DecMurphy AJdoi: 10.1016/j.humpath.2008.04.019
12914969Wilms' tumor suppressor (WT1) is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer's disease.Brain Res2003 Sep 5Lovell MA-
12200377CD8 T-cell responses to Wilms tumor gene product WT1 and proteinase 3 in patients with acute myeloid leukemia.Blood2002 Sep 15Scheibenbogen C-
14988155Use of B cell-bound HLA-A2 class I monomers to generate high-avidity, allo-restricted CTLs against the leukemia-associated protein Wilms tumor antigen.Blood2004 Jun 15Savage P-
12239212Inhibition of Wilms tumor 1 transactivation by bone marrow zinc finger 2, a novel transcriptional repressor.J Biol Chem2002 Nov 22Lee TH-
17721194Diagnostic utility of WT1 immunostaining in ovarian sertoli cell tumor.Am J Surg Pathol2007 SepZhao C-
25510679The Wilms' tumour suppressor Wt1 is a major regulator of tumour angiogenesis and progression.Nat Commun2014 Dec 16Wagner KDdoi: 10.1038/ncomms6852.
17487399VEGF transcription and mRNA stability are altered by WT1 not DDS(R384W) expression in LNCaP cells.Oncol Rep2007 JunCash J-
15957141Novel familial WT1 read-through mutation associated with Wilms tumor and slow progressive nephropathy.Am J Kidney Dis2005 JunZirn B-
17540436Expression level of Wilms tumor 1 (WT1) protein has limited prognostic value in epithelial ovarian cancer: from the Danish MALOVA ovarian cancer study.Gynecol Oncol2007 AugHogdall EV-
19549856An integrated genome screen identifies the Wnt signaling pathway as a major target of WT1.Proc Natl Acad Sci U S A2009 Jul 7Kim MKdoi: 10.1073/pnas.0901591106
22510877Human Langerhans cells use an IL-15R-α/IL-15/pSTAT5-dependent mechanism to break T-cell tolerance against the self-differentiation tumor antigen WT1.Blood2012 May 31Romano Edoi: 10.1182/blood-2011-09-382200
18722603Wilms' tumor gene 1 (WT1) overexpression in neurons in deep endometriosis: a pilot study.Fertil Steril2009 AprCoosemans Adoi: 10.1016/j.fertnstert.2008.06.042
16927106WT1 and glomerular diseases.Pediatr Nephrol2006 NovNiaudet P-
25454478Low-grade small round cell tumor of the cauda equina with EWSR1-WT1 fusion and indolent clinical course.Hum Pathol2015 JanUd Din Ndoi: 10.1016/j.humpath.2014.09.015
21734473Wilms tumor gene 1 (WT1) is a prognostic marker in high-grade uterine sarcoma.Int J Gynecol Cancer2011 FebCoosemans Adoi: 10.1097/IGC.0b013e318207cab5.
25748047Wilms' tumor 1 (WT1) expression and prognosis in solid cancer patients: a systematic review and meta-analysis.Sci Rep2015 Mar 9Qi XWdoi: 10.1038/srep08924.
26224397Wilms tumor gene single nucleotide polymorphism rs16754 predicts a favorable outcome in children with acute lymphoblastic leukemia.J Cancer Res Clin Oncol2015 DecJunghanns ASdoi: 10.1007/s00432-015-2018-y
23142971Wilms' tumor 1 gene modulates Fas-related death signals and anti-apoptotic functions in hepatocellular carcinoma.J Gastroenterol2013 SepUesugi Kdoi: 10.1007/s00535-012-0708-7
22030397WT1 protein directly regulates expression of vascular endothelial growth factor and is a mediator of tumor response to hypoxia.J Biol Chem2011 Dec 23McCarty Gdoi: 10.1074/jbc.M111.310128
14767530Suppression of prostate tumor cell growth in vivo by WT1, the Wilms' tumor suppressor gene.Int J Oncol2004 MarFraizer G-
17205055Wilms' tumour 1 mutations are associated with FLT3-ITD and failure of standard induction chemotherapy in patients with normal karyotype AML.Leukemia2007 MarSummers K-
23554000A novel WT1 mutation in familial wilms tumor.Pediatr Blood Cancer2013 AugMelchionda Fdoi: 10.1002/pbc.24539
22313360Novel report of expression and function of CD97 in malignant gliomas: correlation with Wilms tumor 1 expression and glioma cell invasiveness.J Neurosurg2012 AprChidambaram Adoi: 10.3171/2011.11.JNS111455
12411326Two distinct HLA-A0201-presented epitopes of the Wilms tumor antigen 1 can function as targets for leukemia-reactive CTL.Blood2002 Nov 15Bellantuono I-
26200099Microcystic Stromal Tumor: A Distinctive Ovarian Sex Cord-Stromal Neoplasm Characterized by FOXL2, SF-1, WT-1, Cyclin D1, and β-catenin Nuclear Expression and CTNNB1 Mutations.Am J Surg Pathol2015 OctIrving JAdoi: 10.1097/PAS.0000000000000482.
24619359Classification of a frameshift/extended and a stop mutation in WT1 as gain-of-function mutations that activate cell cycle genes and promote Wilms tumour cell proliferation.Hum Mol Genet2014 Aug 1Busch Mdoi: 10.1093/hmg/ddu111
22673530Immunohistochemical expression of Wilms' tumor protein (WT1) in developing human epithelial and mesenchymal tissues.Acta Histochem2013 JanParenti Rdoi: 10.1016/j.acthis.2012.04.006
19097357Examination of expression of WT1 gene product and CD44 adhesive molecule in nephroblastoma histologic types.Pol J Pathol2008Taran K-
20736771WT1 immunoprofiling and comparison of malignant Mullerian mixed tumors of the female genital tract.Int J Gynecol Pathol2010 SepFranko Adoi: 10.1097/PGP.0b013e3181d55597.
17972942The hDMP1 tumor suppressor is a new WT1 target in myeloid leukemias.Leukemia2008 MayTschan MP-
23480492Detection and preliminary characterization of CD8+T lymphocytes specific for Wilms' tumor antigen in patients with non-Hodgkin lymphoma.Leuk Lymphoma2013 NovIsrayelyan Adoi: 10.3109/10428194.2013.783910
15253707Prevalence of WT1 mutations in a large cohort of patients with steroid-resistant and steroid-sensitive nephrotic syndrome.Kidney Int2004 AugRuf RG-
20595692Genotype/phenotype correlation in nephrotic syndrome caused by WT1 mutations.Clin J Am Soc Nephrol2010 SepChernin Gdoi: 10.2215/CJN.09351209
19190340Wilms' tumor 1 gene expression in hepatocellular carcinoma promotes cell dedifferentiation and resistance to chemotherapy.Cancer Res2009 Feb 15Perugorria MJdoi: 10.1158/0008-5472.CAN-08-2545
12824878Overexpression of the Wilms' tumor gene WT1 in head and neck squamous cell carcinoma.Cancer Sci2003 JunOji Y-
18528287Cytoplasmic overexpression of WT-1 in gastrointestinal stromal tumor and other soft tissue tumors.Appl Immunohistochem Mol Morphol2008 JulBing Zdoi: 10.1097/PAI.0b013e31815c2e02.
19137020Canonical WNT signalling determines lineage specificity in Wilms tumour.Oncogene2009 Feb 26Fukuzawa Rdoi: 10.1038/onc.2008.455
24927120Mechanisms of transcriptional regulation by WT1 (Wilms' tumour 1).Biochem J2014 Jul 1Toska Edoi: 10.1042/BJ20131587.
28400619Dysfunction of the WT1-MEG3 signaling promotes AML leukemogenesis via p53-dependent and -independent pathways.Leukemia2017 DecLyu Ydoi: 10.1038/leu.2017.116
27417955WT1 Mutation in Childhood Cancer.Methods Mol Biol2016Charlton Jdoi: 10.1007/978-1-4939-4023-3_1.
28498419miR-590 regulates WT1 during proliferation of G401 cells.Mol Med Rep2017 JulHong Ldoi: 10.3892/mmr.2017.6561
22672247Expression of Wilms' tumor 1 (WT1) in oral squamous cell carcinoma.J Oral Pathol Med2013 FebMikami Tdoi: 10.1111/j.1600-0714.2012.01182.x
12127961Downregulation of Wilms' tumor 1 protein inhibits breast cancer proliferation.Biochem Biophys Res Commun2002 Jul 26Zapata-Benavides P-
29040381The CUG-translated WT1, not AUG-WT1, is an oncogene.Carcinogenesis2017 Dec 7Lee KYdoi: 10.1093/carcin/bgx108.
23298185The Wilms' tumor gene (WT1) regulates E-cadherin expression and migration of prostate cancer cells.Mol Cancer2013 Jan 8Brett Adoi: 10.1186/1476-4598-12-3.
18292948Wilms' tumor gene WT1-shRNA as a potent apoptosis-inducing agent for solid tumors.Int J Oncol2008 MarTatsumi N-
23945386WT1 promotes invasion of NSCLC via suppression of CDH1.J Thorac Oncol2013 SepWu Cdoi: 10.1097/JTO.0b013e31829f6a5f.
22797561High Wilms' tumor 1 mRNA expression correlates with basal-like and ERBB2 molecular subtypes and poor prognosis of breast cancer.Oncol Rep2012 OctQi XWdoi: 10.3892/or.2012.1906
15365188Induction of WT1 (Wilms' tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccine and the resultant cancer regression.Proc Natl Acad Sci U S A2004 Sep 21Oka Y-
18708366Wilms' tumor 1 suppressor gene mediates antiestrogen resistance via down-regulation of estrogen receptor-alpha expression in breast cancer cells.Mol Cancer Res2008 AugHan Ydoi: 10.1158/1541-7786.MCR-07-2179.
17599043Wilms' tumor protein 1: an early target of progestin regulation in T-47D breast cancer cells that modulates proliferation and differentiation.Oncogene2008 Jan 3Caldon CE-
12841869Overexpression of the Wilms' tumor gene WT1 in primary thyroid cancer.Cancer Sci2003 JulOji Y-
12960088The WT1 Wilms' tumor suppressor gene: a novel target for insulin-like growth factor-I action.Endocrinology2003 OctBentov I-
25929687Wilms' tumor gene 1 regulates p63 and promotes cell proliferation in squamous cell carcinoma of the head and neck.BMC Cancer2015 May 1Li Xdoi: 10.1186/s12885-015-1356-0.
21867623[Detection of WT1 gene in acute myeloid leukemia children by real-time fluorescent quantitative RT-PCR and its clinical significance].Zhongguo Shi Yan Xue Ye Xue Za Zhi2011 AugZhang R-
17940140Alternately spliced WT1 antisense transcripts interact with WT1 sense RNA and show epigenetic and splicing defects in cancer.RNA2007 DecDallosso AR-
17706117[Promoter methylation and mRNA expression of WT1 gene in MCF10 breast cancer model].Zhonghua Bing Li Xue Za Zhi2007 AprYang JL-
26573232A genome-wide association study identifies WT1 variant with better response to 5-fluorouracil, pirarubicin and cyclophosphamide neoadjuvant chemotherapy in breast cancer patients.Oncotarget2016 Jan 26Wu Ldoi: 10.18632/oncotarget.5837.
19443388Immunohistochemical detection of WT1 protein in endometrial cancer.Anticancer Res2009 MayOhno S-
14666652Inhibition of breast cancer cell growth by the Wilms' tumor suppressor WT1 is associated with a destabilization of beta-catenin.Anticancer Res2003 Sep-OctZhang TF-
23888944Transcription factor WT1 and promoter CpG hypomethylation coactivate HOXA10 expression in ovarian cancer.Curr Pharm Des2014Jiang Y-
24778040High levels of Wilms' tumor 1 (WT1) expression were associated with aggressive clinical features in ovarian cancer.Anticancer Res2014 MayLiu Z-
23207289The significance of Wilms Tumor Gene (WT1) and p53 expression in curettage specimens of patients with endometrial carcinomas.Pathol Res Pract2013 Jan 15Matalka Idoi: 10.1016/j.prp.2012.10.002
22925896WT1 CpG islands methylation in human lung cancer: a pilot study.Biochem Biophys Res Commun2012 Sep 28Bruno Pdoi: 10.1016/j.bbrc.2012.08.059
24596380Correlation of Wilms' tumor 1 isoforms with HER2 and ER-α and its oncogenic role in breast cancer.Anticancer Res2014 MarNasomyon T-
18751389The Wilms' tumor suppressor WT1 inhibits malignant progression of neoplastigenic mammary epithelial cells.Anticancer Res2008 Jul-AugWang L-
20204298The Wilms' tumor suppressor WT1 induces estrogen-independent growth and anti-estrogen insensitivity in ER-positive breast cancer MCF7 cells.Oncol Rep2010 AprWang L-
26406403Clinicopathological significance and prognostic value of Wilms' tumor gene expression in colorectal cancer.Cancer Biomark2015Miyata Ydoi: 10.3233/CBM-150521.
21710692Frequent promoter hypermethylation of BRCA2, CDH13, MSH6, PAX5, PAX6 and WT1 in ductal carcinoma in situ and invasive breast cancer.J Pathol2011 OctMoelans CBdoi: 10.1002/path.2930
15674342HER2/neu increases the expression of Wilms' Tumor 1 (WT1) protein to stimulate S-phase proliferation and inhibit apoptosis in breast cancer cells.Oncogene2005 Feb 24Tuna M-
15286719Transcriptional activation of c-myc proto-oncogene by WT1 protein.Oncogene2004 Sep 9Han Y-
27922671Differential detection of cytoplasmic Wilms tumor 1 expression by immunohistochemistry, western blotting and mRNA quantification.Int J Oncol2017 JanMaki Tdoi: 10.3892/ijo.2016.3786
29016617MicroRNA-193a inhibits breast cancer proliferation and metastasis by downregulating WT1.PLoS One2017 Oct 10Xie Fdoi: 10.1371/journal.pone.0185565
29024629The role of WT1 isoforms in vasculogenic mimicry and metastatic potential of human triple negative breast cancer cells.Biochem Biophys Res Commun2017 Dec 9Bissanum Rdoi: 10.1016/j.bbrc.2017.10.043
29291617Methylation Status of Transcriptional Modulatory Genes Associated with Colorectal Cancer in Northeast China.Gut Liver2018 Mar 15Gao HLdoi: 10.5009/gnl17163.
28345629WT1 expression in breast cancer disrupts the epithelial/mesenchymal balance of tumour cells and correlates with the metabolic response to docetaxel.Sci Rep2017 Mar 27Artibani Mdoi: 10.1038/srep45255.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr11324396605'Flanknovel0.39
ACCchr1132392694Missense_MutationnovelQ437H0.55
BLCAchr1132389059Nonstop_MutationNA*518Sext*220.45
BLCAchr1132434820Missense_MutationNAR176C0.25
BLCAchr1132389142SilentnovelQ490Q0.53
BLCAchr1132396356Missense_MutationnovelE384K0.18
BLCAchr1132392691SilentnovelL438L0.22
BLCAchr11324390655'Flanknovel0.14
BRCAchr1132392006SilentNAL466L0.12
BRCAchr1132389111Missense_MutationNAR501C0.15
BRCAchr11324388845'FlankNA0.45
BRCAchr1132392704Missense_Mutationrs121907901R434H0.45
BRCAchr1132417595Frame_Shift_InsnovelL311Sfs*330.03
BRCAchr11323889843'UTRnovel0.63
BRCAchr1132428573Silentrs768828897T231T0.16
BRCAchr11323883383'UTRnovel0.45
BRCAchr1132430534Intronnovel0.09
BRCAchr1132430536Intronnovel0.09
CESCchr1132434868Missense_MutationnovelF160V0.11
CESCchr1132417636Missense_MutationNAM297I0.13
CESCchr11324397515'Flanknovel0.07
CESCchr1132434814Missense_MutationNAG178R0.09
CESCchr1132430668Intronnovel0.39
CESCchr11324396065'FlankNA0.27
CESCchr1132399960SilentnovelF362F0.17
CESCchr11324394725'Flankrs7697994240.39
COADchr1132392756Splice_SiteNAX417_splice0.23
COADchr1132428555SilentNAA237A0.28
COADchr1132430707Intronnovel0.5
COADchr11324394805'FlankNA0.42
COADchr11324394435'Flanknovel0.16
COADchr11324391625'Flanknovel0.38
COADchr11324395545'Flanknovel0.24
COADchr11324397255'Flanknovel0.22
COADchr11324400505'FlankNA0.16
COADchr1132389137Missense_MutationNAK492R0.35
COADchr11324391295'Flanknovel0.31
COADchr11324390755'Flanknovel0.48
COADchr11324394805'FlankNA0.33
COADchr11324392875'Flanknovel0.45
COADchr11324388225'Flanknovel0.69
COADchr1132392019Missense_MutationNAR462Q0.24
COADchr11324395495'Flankrs5594375080.52
COADchr11324400505'FlankNA0.4
COADchr1132392028Missense_MutationNAK459T0.26
COADchr1132389064Silentrs202118284A516A0.16
COADchr1132392052Missense_MutationnovelF451Y0.08
COADchr11324397595'Flanknovel0.44
COADchr11324395505'FlankNA0.25
COADchr11324389195'Flanknovel0.31
COADchr11324393015'Flanknovel0.5
COADchr11324389205'Flankrs5587529290.33
COADchr11324395235'Flanknovel0.27
COADchr11324400735'Flanknovel0.25
COADchr1132396304Missense_MutationNAR401K0.25
COADchr11324394805'FlankNA0.43
COADchr11324400735'Flanknovel0.54
COADchr1132430667Intronnovel0.56
COADchr1132392019Missense_MutationNAR462Q0.32
COADchr1132428603SilentNAT221T0.32
COADchr11324400505'FlankNA0.31
COADchr11324394805'FlankNA0.28
DLBCchr1132434851Silentrs772890986S165S0.38
ESCAchr1132434852Missense_MutationNAS165F0.16
ESCAchr11324396815'Flanknovel0.2
ESCAchr1132417579Missense_MutationnovelK316N0.41
ESCAchr1132434708Missense_MutationNAR213L0.12
ESCAchr11323886603'UTRnovel0.38
ESCAchr11324391265'Flanknovel0.16
ESCAchr1132430723Intronnovel0.58
ESCAchr11324392675'Flanknovel0.21
ESCAchr1132400009Missense_MutationNAT346M0.23
GBMchr11323889953'UTRnovel0.07
GBMchr1132399959SilentnovelR363R0.35
GBMchr1132428568Missense_MutationNAS233L0.53
GBMchr1132392032Nonsense_Mutationrs121907909R458*0.33
HNSCchr1132417576Splice_SitenovelX317_splice0.15
HNSCchr1132396401Nonsense_MutationNAR369*0.33
HNSCchr1132396333Silentrs200539928F391F0.27
HNSCchr11324389565'Flanknovel0.32
HNSCchr1132392019Missense_MutationNAR462L0.23
KIRCchr11324392875'Flanknovel0.1
KIRCchr1132396353Missense_MutationNAT385S0.32
KIRCchr1132399986Missense_MutationNAY354N0.26
LAMLchr1132396364Frame_Shift_InsNAS381Lfs*710.36
LAMLchr1132389110Missense_MutationNAR501H0.03
LAMLchr1132396368Frame_Shift_InsNAR380Dfs*80.05
LAMLchr1132392020Missense_Mutationrs121907900R462W0.31
LAMLchr1132396395Frame_Shift_InsNAV371Cfs*140.38
LAMLchr1132396399Frame_Shift_InsNAR370Tfs*150.52
LAMLchr1132396363Frame_Shift_InsNAA382Gfs*30.38
LAMLchr1132396363Frame_Shift_InsNAA382Gfs*30.06
LAMLchr1132396364Nonsense_MutationnovelS381*0.06
LAMLchr1132392011Missense_MutationNAH465Y0.23
LGGchr1132400039Missense_Mutationrs371021920S336N0.33
LIHCchr1132392015SilentnovelS463S0.18
LIHCchr1132435339Missense_MutationnovelD3N0.34
LIHCchr1132392746Missense_MutationnovelP420R0.36
LIHCchr1132427954Splice_SitenovelX291_splice0.09
LIHCchr1132392702Missense_MutationNAS435P0.41
LIHCchr1132428518Missense_MutationnovelM250L0.4
LUADchr1132392065Splice_SitenovelX447_splice0.16
LUADchr1132434889Missense_MutationNAE153K0.26
LUADchr1132428599Missense_MutationnovelD223Y0.22
LUADchr1132417484Intronnovel0.57
LUADchr1132392022Missense_MutationNAS461Y0.16
LUADchr1132392022Missense_MutationnovelS461F0.11
LUADchr1132389079SilentnovelT511T0.35
LUADchr1132392726Missense_MutationNAD427Y0.1
LUADchr1132417559Intronnovel0.34
LUADchr1132392064Missense_MutationNAG447V0.35
LUADchr1132392055Missense_MutationNAP450Q0.14
LUADchr1132391974Missense_MutationNAT477K0.28
LUADchr1132430580Intronnovel0.31
LUADchr1132391971Splice_SiteNAX478_splice0.28
LUADchr1132434899SilentnovelA149A0.26
LUADchr1132391987Missense_MutationNAH473Y0.14
LUADchr1132434933Missense_MutationnovelS138Y0.39
LUADchr1132434836SilentNAG170G0.15
LUADchr1132428581Missense_MutationnovelG229C0.37
LUADchr1132392019Missense_MutationNAR462L0.22
LUADchr1132417634Missense_MutationnovelT298I0.21
LUADchr11324390315'Flanknovel0.3
LUADchr1132392741Missense_MutationnovelQ422K0.26
LUADchr11324389515'Flanknovel0.16
LUSCchr1132417580Missense_MutationNAK316T0.11
LUSCchr11323890553'UTRnovel0.25
LUSCchr1132392728Missense_MutationnovelK426R0.41
LUSCchr11324391175'FlankNA0.47
LUSCchr1132389065Missense_Mutationrs749266841A516V0.26
LUSCchr1132399986Missense_MutationNAY354D0.39
LUSCchr1132417630SilentNAS299S0.13
LUSCchr1132389072Nonsense_MutationnovelQ514*0.21
LUSCchr1132396378SilentNAP376P0.37
LUSCchr1132428551Missense_MutationNAF239L0.27
LUSCchr1132417654Splice_RegionnovelS291S0.25
LUSCchr11324388925'FlankNA0.1
LUSCchr1132428549SilentNAF239F0.15
LUSCchr11324391165'FlankNA0.35
LUSCchr1132430555Intronnovel0.2
LUSCchr1132434788Missense_MutationNAS186R0.47
LUSCchr1132430600Intronnovel0.21
LUSCchr11323890463'UTRrs774626620.28
LUSCchr1132427970Missense_MutationnovelR286S0.5
LUSCchr1132392031Missense_MutationNAR458Q0.15
LUSCchr1132399996SilentnovelC350C0.24
LUSCchr11323890383'UTRnovel0.23
LUSCchr1132434783Missense_MutationnovelA188E0.19
LUSCchr1132392726Missense_MutationnovelD427N0.46
LUSCchr11324389895'Flanknovel0.11
MESOchr1132434974In_Frame_DelnovelG120_P124del0.37
OVchr1132417634Missense_MutationnovelT298R0.08
OVchr11324390265'Flanknovel0.12
OVchr1132392752Missense_MutationnovelE418V0.03
PAADchr11324389925'Flanknovel0.19
PCPGchr1132428542Missense_MutationNAH242N0.3
PRADchr1132389172Missense_MutationnovelK480N0.36
PRADchr1132392032Nonsense_Mutationrs121907909R458*0.5
PRADchr1132396293SilentnovelL405L0.39
READchr1132389064Silentrs202118284A516A0.37
READchr1132434810Missense_MutationNAP179L0.38
READchr11324400505'FlankNA0.54
READchr1132400024Missense_MutationnovelS341N0.25
SARCchr11324395105'Flanknovel0.45
SARCchr1132417550Intronnovel0.22
SARCchr11324388395'FlankNA0.47
SKCMchr11323890503'UTRnovel0.23
SKCMchr1132417526Intronnovel0.38
SKCMchr11324388925'FlankNA0.4
SKCMchr11324388805'FlankNA0.3
SKCMchr11323889663'UTRnovel0.26
SKCMchr11324388695'Flanknovel0.18
SKCMchr11324389065'FlankNA0.31
SKCMchr1132389123Missense_MutationNAD497N0.29
SKCMchr1132430590Intronnovel0.5
SKCMchr1132430542Intronnovel0.15
SKCMchr11323889663'UTRnovel0.44
SKCMchr1132417586Missense_MutationnovelT314I0.32
SKCMchr1132389171Missense_MutationnovelP481S0.26
SKCMchr1132389169SilentNAP481P0.26
SKCMchr1132391980Missense_MutationNAG475D0.45
SKCMchr1132392676SilentNAR443R0.35
SKCMchr1132434754Missense_MutationNAN198Y0.31
SKCMchr11324388395'FlankNA0.52
SKCMchr11323890483'UTRrs7578072470.17
SKCMchr11324390395'Flankrs7492626390.12
SKCMchr1132417583Missense_MutationNAL315S0.39
SKCMchr11323889673'UTRnovel0.62
SKCMchr1132392716Missense_Mutationrs144788858R430Q0.33
SKCMchr1132400022Missense_Mutationrs267602851D342N0.17
SKCMchr1132417526Intronnovel0.44
SKCMchr1132400022Missense_Mutationrs267602851D342N0.45
SKCMchr1132417518Intronnovel0.41
SKCMchr1132434748Missense_MutationnovelP200S0.29
SKCMchr1132416507Nonsense_MutationNAW328*0.15
SKCMchr11323889793'UTRnovel0.2
STADchr1132392028Missense_MutationNAK459T0.31
STADchr11324390735'Flanknovel0.22
STADchr11324391435'Flanknovel0.54
STADchr11324389815'Flanknovel0.16
STADchr1132428585Silentrs9332974S227S0.2
STADchr1132396324SilentNAA394A0.07
STADchr1132430570Intronnovel0.24
STADchr1132417648Missense_MutationNAN293K0.42
STADchr1132428005Missense_MutationNAD275N0.32
STADchr11324389885'Flanknovel0.23
STADchr11324390145'Flanknovel0.17
STADchr11324388545'Flanknovel0.27
STADchr1132417538IntronNA0.19
STADchr11324388675'Flanknovel0.19
STADchr11323890153'UTRnovel0.23
STADchr1132389135Missense_MutationnovelF493L0.3
STADchr1132417538IntronNA0.6
STADchr1132434935SilentnovelH137H0.28
STADchr1132399972SilentNAT358T0.19
STADchr1132428031Frame_Shift_DelNAP266Rfs*200.25
THCAchr1132392676Missense_MutationNAR443S0.1
THCAchr11324389655'Flankrs7518121920.13
UCECchr1132392019Missense_MutationNAR462L0.5
UCECchr1132396384SilentnovelV374V0.27
UCECchr1132434861Missense_MutationnovelV162A0.08
UCECchr1132396368Missense_Mutationrs765218093R380W0.39
UCECchr11323880263'UTRnovel0.12
UCECchr1132417459Intronnovel0.4
UCECchr11324397855'Flanknovel0.33
UCECchr1132396321SilentnovelY395Y0.09
UCECchr1132434735Missense_MutationnovelS204I0.3
UCECchr1132417560Intronnovel0.44
UCECchr11324388915'Flanknovel0.08
UCECchr1132428609SilentnovelT219T0.24
UCECchr1132399972SilentNAT358T0.17
UCECchr11324397665'Flanknovel0.28
UCECchr11324387805'Flanknovel0.22
UCECchr1132392041Missense_MutationnovelT455P0.09
UCECchr1132417613Missense_MutationNAT305I0.34
UCECchr1132434715Missense_Mutationrs778069787A211T0.52
UCECchr1132430683Intronnovel0.26
UCECchr11324399505'Flanknovel0.43
UCECchr11323881493'UTRnovel0.39
UCECchr1132396401Nonsense_MutationNAR369*0.41
UCECchr1132430625IntronNA0.44
UCECchr11324393295'Flanknovel0.38
UCECchr11324399205'Flanknovel0.31
UCECchr11324389815'Flanknovel0.37
UCECchr1132417564Intronnovel0.27
UCECchr11323884833'UTRnovel0.56
UCECchr1132434814Missense_MutationNAG178R0.53
UCECchr11324387985'Flanknovel0.33
UCECchr11323886773'UTRnovel0.46
UCECchr11324397855'Flanknovel0.15
UCECchr11324398755'Flanknovel0.17
UCECchr11323879833'UTRnovel0.37
UCECchr1132417538IntronNA0.38
UCECchr11324396665'Flanknovel0.58
UCECchr11324389795'Flankrs7482594500.13
UCECchr1132417590Missense_MutationnovelA313T0.12
UCECchr1132430639Intronnovel0.09
UCECchr11324399135'Flanknovel0.33
UCECchr11324390505'Flankrs7763330980.32
UCECchr11324400155'FlankNA0.57
UCECchr11323882913'UTRnovel0.3
UCECchr1132391996Missense_MutationnovelT470A0.28
UCECchr1132428558Silentrs779321799A236A0.47
UCECchr1132430707Intronnovel0.29
UCECchr11324395515'Flanknovel0.5
UCECchr11324398925'Flanknovel0.33
UCECchr11323883073'UTRnovel0.55
UCECchr1132428502Missense_MutationnovelS255L0.47
UCECchr1132430720Intronnovel0.38
UCECchr1132389110Missense_MutationNAR501H0.14
UCECchr1132417624SilentnovelL301L0.04
UCECchr11323882033'UTRnovel0.45
UCECchr11323886543'UTRnovel0.43
UCECchr1132434876Missense_MutationnovelL157P0.14
UCECchr11324394955'Flanknovel0.18
UCECchr11323889173'UTRnovel0.56
UCECchr11324400145'Flanknovel0.44
UCECchr11324388065'FlankNA0.37
UCECchr11323884093'UTRnovel0.35
UCECchr11323879983'UTRnovel0.21
UCECchr11324396315'FlankNA0.46
UCECchr11324396325'Flanknovel0.33
UCECchr11323880783'UTRnovel0.31
UCECchr11324390215'Flanknovel0.32
UCECchr11323886173'UTRnovel0.31
UCECchr1132417543Intronnovel0.24
UCSchr11324390465'Flanknovel0.41

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ESCAAMP0.18480.018342
TGCTDEL0.580.21504

Survival Analysis
CancerP-value Q-value
THYM0.016

Kaplan-Meier Survival Analysis

KIRC0.00015

Kaplan-Meier Survival Analysis

STAD0.018

Kaplan-Meier Survival Analysis

SARC0.014

Kaplan-Meier Survival Analysis

MESO0.00021

Kaplan-Meier Survival Analysis

ACC0.0001

Kaplan-Meier Survival Analysis

HNSC0.012

Kaplan-Meier Survival Analysis

LUSC0.019

Kaplan-Meier Survival Analysis

BRCA0.0018

Kaplan-Meier Survival Analysis

KIRP0.01

Kaplan-Meier Survival Analysis

COAD0.0086

Kaplan-Meier Survival Analysis

BLCA0.018

Kaplan-Meier Survival Analysis

READ0.015

Kaplan-Meier Survival Analysis

LAML0.0046

Kaplan-Meier Survival Analysis

KICH0.032

Kaplan-Meier Survival Analysis

UCEC0.03

Kaplan-Meier Survival Analysis

LIHC0.0015

Kaplan-Meier Survival Analysis

LGG0.00012

Kaplan-Meier Survival Analysis

THCA0.014

Kaplan-Meier Survival Analysis

LUAD0.036

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000184937 (Gene tree)
Gene ID
7490
Gene Symbol
WT1
Alias
WAGR|WIT-2|AWT1|NPHS4|GUD
Full Name
WT1 transcription factor
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
47,856 bases
Position
chr11:32,387,775-32,435,630
Accession
12796
RBP type
canonical RBP
Summary
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000435307zf-C2H2PF00096.268.9e-1513
ENSP00000435307zf-C2H2PF00096.268.9e-1523
ENSP00000435307zf-C2H2PF00096.268.9e-1533
ENSP00000368370zf-C2H2PF00096.261.2e-1413
ENSP00000368370zf-C2H2PF00096.261.2e-1423
ENSP00000368370zf-C2H2PF00096.261.2e-1433
ENSP00000492269zf-C2H2PF00096.261.4e-1312
ENSP00000492269zf-C2H2PF00096.261.4e-1322
ENSP00000415516zf-C2H2PF00096.261.4e-1312
ENSP00000415516zf-C2H2PF00096.261.4e-1322
ENSP00000491511zf-C2H2PF00096.261.7e-1312
ENSP00000491511zf-C2H2PF00096.261.7e-1322
ENSP00000413452zf-C2H2PF00096.261.7e-1312
ENSP00000413452zf-C2H2PF00096.261.7e-1322
ENSP00000491984zf-C2H2PF00096.261.7e-1312
ENSP00000491984zf-C2H2PF00096.261.7e-1322
ENSP00000331327zf-C2H2PF00096.261.7e-1312
ENSP00000331327zf-C2H2PF00096.261.7e-1322
ENSP00000435624zf-C2H2PF00096.262e-0912
ENSP00000435624zf-C2H2PF00096.262e-0922
ENSP00000492269WT1PF02165.153.6e-15611
ENSP00000415516WT1PF02165.153.6e-15611
ENSP00000491511WT1PF02165.151.3e-14812
ENSP00000491511WT1PF02165.151.3e-14822
ENSP00000413452WT1PF02165.151.3e-14812
ENSP00000413452WT1PF02165.151.3e-14822
ENSP00000491984WT1PF02165.151.3e-14812
ENSP00000491984WT1PF02165.151.3e-14822
ENSP00000331327WT1PF02165.151.3e-14812
ENSP00000331327WT1PF02165.151.3e-14822
ENSP00000435307WT1PF02165.151e-9011
ENSP00000368370WT1PF02165.152.7e-8411
ENSP00000435351WT1PF02165.151.8e-5912
ENSP00000435351WT1PF02165.151.8e-5922
ENSP00000435624WT1PF02165.151.6e-2411

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
27417971Methods to Identify and Validate WT1-RNA Interaction.Methods Mol Biol2016Bharathavikru Rdoi: 10.1007/978-1-4939-4023-3_17.
7493135The emerging molecular genetics of sarcoma translocations.Diagn Mol Pathol1995 SepLadanyi M-
9512553Overlapping RNA and DNA binding domains of the wt1 tumor suppressor gene product.Nucleic Acids Res1998 Apr 1Bardeesy N-
8896454Regulation of WT1 by phosphorylation: inhibition of DNA binding, alteration of transcriptional activity and cellular translocation.EMBO J1996 Oct 15Ye Y-
12970737Transcriptional activity of testis-determining factor SRY is modulated by the Wilms' tumor 1 gene product, WT1.Oncogene2003 Sep 11Matsuzawa-Watanabe Y-
20885852WT1 and kidney progenitor cells.Organogenesis2010 Apr-JunKreidberg JA-
7862627Characterization of the genomic breakpoint and chimeric transcripts in the EWS-WT1 gene fusion of desmoplastic small round cell tumor.Proc Natl Acad Sci U S A1995 Feb 14Gerald WL-
12215008Regulation of gene expression by WT1 in development and tumorigenesis.Int J Hematol2002 AugEllisen LW-
25375204How mRNA is misspliced in acute myelogenous leukemia (AML)?Oncotarget2014 Oct 30Mohamed AM-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000530998WT1-2092421-ENSP00000435307288 (aa)-P19544
ENST00000526685WT1-206718-ENSP0000043629225 (aa)-E9PPW3
ENST00000379079WT1-2032466-ENSP00000368370302 (aa)-P19544
ENST00000379077WT1-2023032-ENSP00000368368317 (aa)-H0Y3F0
ENST00000639907WT1-2111545-ENSP00000491511514 (aa)-A0A1W2PPP2
ENST00000640146WT1-2121554-ENSP00000491984517 (aa)-A0A1W2PR07
ENST00000448076WT1-2042114-ENSP00000413452514 (aa)-H0Y7K5
ENST00000527882WT1-208551-ENSP00000435624178 (aa)-H0YED9
ENST00000639563WT1-2101494-ENSP00000492269497 (aa)-A0A1W2PQQ0
ENST00000332351WT1-2013122-ENSP00000331327517 (aa)-J3KNN9
ENST00000527775WT1-207578-ENSP00000435351131 (aa)-E9PKS2
ENST00000452863WT1-2052768-ENSP00000415516497 (aa)-A0A0A0MT54
Gene Model
Click here to download ENSG00000184937's gene model file
Pathways
Pathway IDPathway NameSource
hsa05202Transcriptional misregulation in cancerKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000184937Hernia, Inguinal4E-1426686553
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000184937rs49868111132429547GRubella-specific interleukin-6 secretion29253144EFO_0004810|EFO_0004645
ENSG00000184937rs50301791132426709?Systolic blood pressure30595370EFO_0006335
ENSG00000184937rs71105471132425801?Waist-hip ratio30595370EFO_0004343
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000184937's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000184937WT1100100.000ENSAPOG00000000289wt1a10070.588Acanthochromis_polyacanthus
ENSG00000184937WT110088.000ENSAPOG00000011422wt1b9963.820Acanthochromis_polyacanthus
ENSG00000184937WT1100100.000ENSAMEG00000006957WT110091.686Ailuropoda_melanoleuca
ENSG00000184937WT110088.000ENSACIG00000005676wt1b9963.719Amphilophus_citrinellus
ENSG00000184937WT1100100.000ENSACIG00000005841wt1a10069.011Amphilophus_citrinellus
ENSG00000184937WT110088.000ENSAOCG00000011027wt1b9864.172Amphiprion_ocellaris
ENSG00000184937WT17862.791ENSAOCG00000002699wt1a9963.178Amphiprion_ocellaris
ENSG00000184937WT1100100.000ENSAOCG00000005965-9684.783Amphiprion_ocellaris
ENSG00000184937WT1100100.000ENSAPEG00000007652wt1a10070.495Amphiprion_percula
ENSG00000184937WT110088.000ENSAPEG00000007784wt1b9855.580Amphiprion_percula
ENSG00000184937WT1100100.000ENSATEG00000009147wt1a10071.910Anabas_testudineus
ENSG00000184937WT110084.000ENSATEG00000022506wt1b9862.812Anabas_testudineus
ENSG00000184937WT1100100.000ENSAPLG00000005775WT110077.112Anas_platyrhynchos
ENSG00000184937WT110092.000ENSACAG00000002480WT110091.319Anolis_carolinensis
ENSG00000184937WT1100100.000ENSANAG00000025090WT110099.103Aotus_nancymaae
ENSG00000184937WT1100100.000ENSACLG00000014317wt1a10069.231Astatotilapia_calliptera
ENSG00000184937WT110088.000ENSACLG00000007937wt1b9864.172Astatotilapia_calliptera
ENSG00000184937WT1100100.000ENSAMXG00000039834wt1a10071.882Astyanax_mexicanus
ENSG00000184937WT110088.000ENSAMXG00000039805wt1b9962.700Astyanax_mexicanus
ENSG00000184937WT1100100.000ENSBTAG00000047268WT110096.607Bos_taurus
ENSG00000184937WT1100100.000ENSCJAG00000005900WT110098.886Callithrix_jacchus
ENSG00000184937WT1100100.000ENSCAFG00000007426WT110095.591Canis_familiaris
ENSG00000184937WT1100100.000ENSCAFG00020002366WT110098.845Canis_lupus_dingo
ENSG00000184937WT1100100.000ENSCHIG00000013048WT110099.111Capra_hircus
ENSG00000184937WT1100100.000ENSTSYG00000034121WT110089.073Carlito_syrichta
ENSG00000184937WT1100100.000ENSCAPG00000000045WT110095.775Cavia_aperea
ENSG00000184937WT1100100.000ENSCPOG00000033316WT110095.312Cavia_porcellus
ENSG00000184937WT1100100.000ENSCCAG00000024307WT110099.338Cebus_capucinus
ENSG00000184937WT1100100.000ENSCATG00000034786WT110099.669Cercocebus_atys
ENSG00000184937WT1100100.000ENSCLAG00000001374WT110095.938Chinchilla_lanigera
ENSG00000184937WT1100100.000ENSCSAG00000005257WT110099.688Chlorocebus_sabaeus
ENSG00000184937WT1100100.000ENSCHOG00000006244WT18598.230Choloepus_hoffmanni
ENSG00000184937WT1100100.000ENSCPBG00000018273WT18283.881Chrysemys_picta_bellii
ENSG00000184937WT1100100.000ENSCANG00000037566WT110099.669Colobus_angolensis_palliatus
ENSG00000184937WT1100100.000ENSCGRG00001005125Wt110097.222Cricetulus_griseus_chok1gshd
ENSG00000184937WT1100100.000ENSCGRG00000008703Wt110097.222Cricetulus_griseus_crigri
ENSG00000184937WT19670.833ENSCSEG00000014378wt1b9742.286Cynoglossus_semilaevis
ENSG00000184937WT110088.000ENSCSEG00000021216wt1a7993.750Cynoglossus_semilaevis
ENSG00000184937WT110088.000ENSCVAG00000019529wt1b9761.644Cyprinodon_variegatus
ENSG00000184937WT110096.000ENSCVAG00000002818wt1a10069.752Cyprinodon_variegatus
ENSG00000184937WT110084.000ENSDARG00000007990wt1b9765.438Danio_rerio
ENSG00000184937WT1100100.000ENSDARG00000031420wt1a10073.121Danio_rerio
ENSG00000184937WT1100100.000ENSDNOG00000003652WT19994.767Dasypus_novemcinctus
ENSG00000184937WT1100100.000ENSDORG00000013725Wt110098.675Dipodomys_ordii
ENSG00000184937WT1100100.000ENSETEG00000000684WT110094.272Echinops_telfairi
ENSG00000184937WT110080.000ENSEBUG00000013909wt1a10049.460Eptatretus_burgeri
ENSG00000184937WT1100100.000ENSEASG00005013477WT110095.164Equus_asinus_asinus
ENSG00000184937WT1100100.000ENSECAG00000022308WT17095.358Equus_caballus
ENSG00000184937WT1100100.000ENSEEUG00000007221WT110099.003Erinaceus_europaeus
ENSG00000184937WT1100100.000ENSELUG00000016479wt1a10074.943Esox_lucius
ENSG00000184937WT110084.000ENSELUG00000023224wt1b9963.170Esox_lucius
ENSG00000184937WT1100100.000ENSFCAG00000000308WT110099.669Felis_catus
ENSG00000184937WT1100100.000ENSFALG00000010820WT110080.742Ficedula_albicollis
ENSG00000184937WT1100100.000ENSFDAG00000006720WT110095.486Fukomys_damarensis
ENSG00000184937WT110092.000ENSFHEG00000020493wt1b9762.955Fundulus_heteroclitus
ENSG00000184937WT110096.000ENSFHEG00000022384wt1a10066.216Fundulus_heteroclitus
ENSG00000184937WT110084.000ENSGMOG00000012296wt1b10062.838Gadus_morhua
ENSG00000184937WT1100100.000ENSGALG00000012115WT110087.327Gallus_gallus
ENSG00000184937WT110076.000ENSGAFG00000002346wt1b9762.187Gambusia_affinis
ENSG00000184937WT110092.000ENSGAFG00000021899wt1a10063.964Gambusia_affinis
ENSG00000184937WT1100100.000ENSGACG00000003299wt1a10062.533Gasterosteus_aculeatus
ENSG00000184937WT110084.000ENSGACG00000016020wt1b10063.719Gasterosteus_aculeatus
ENSG00000184937WT1100100.000ENSGAGG00000000224WT110081.567Gopherus_agassizii
ENSG00000184937WT1100100.000ENSGGOG00000011586WT110099.669Gorilla_gorilla
ENSG00000184937WT1100100.000ENSHBUG00000002527wt1a10069.451Haplochromis_burtoni
ENSG00000184937WT110088.000ENSHBUG00000016837wt1b9964.303Haplochromis_burtoni
ENSG00000184937WT1100100.000ENSHGLG00000004253WT110096.528Heterocephalus_glaber_female
ENSG00000184937WT1100100.000ENSHGLG00100012634WT110096.528Heterocephalus_glaber_male
ENSG00000184937WT110088.000ENSHCOG00000015781wt1a10065.611Hippocampus_comes
ENSG00000184937WT110084.000ENSHCOG00000015039wt1b9861.435Hippocampus_comes
ENSG00000184937WT110088.000ENSIPUG00000012895wt1b10062.100Ictalurus_punctatus
ENSG00000184937WT1100100.000ENSIPUG00000010239wt110072.665Ictalurus_punctatus
ENSG00000184937WT1100100.000ENSSTOG00000023716WT110099.306Ictidomys_tridecemlineatus
ENSG00000184937WT19687.500ENSKMAG00000011114wt1b9860.909Kryptolebias_marmoratus
ENSG00000184937WT110096.000ENSKMAG00000007444wt1a10068.304Kryptolebias_marmoratus
ENSG00000184937WT1100100.000ENSLBEG00000015040wt1a6274.299Labrus_bergylta
ENSG00000184937WT110080.000ENSLBEG00000002082wt1b9862.358Labrus_bergylta
ENSG00000184937WT17057.500ENSLBEG00000004013wt1a9956.904Labrus_bergylta
ENSG00000184937WT1100100.000ENSLACG00000016378WT19980.275Latimeria_chalumnae
ENSG00000184937WT1100100.000ENSLOCG00000004537wt1a10075.973Lepisosteus_oculatus
ENSG00000184937WT1100100.000ENSLAFG00000006160WT110098.444Loxodonta_africana
ENSG00000184937WT1100100.000ENSMFAG00000030746WT110099.669Macaca_fascicularis
ENSG00000184937WT1100100.000ENSMMUG00000009881WT110099.669Macaca_mulatta
ENSG00000184937WT1100100.000ENSMNEG00000010071WT110099.669Macaca_nemestrina
ENSG00000184937WT1100100.000ENSMLEG00000040206WT110099.669Mandrillus_leucophaeus
ENSG00000184937WT110088.000ENSMAMG00000020379wt1b9763.946Mastacembelus_armatus
ENSG00000184937WT1100100.000ENSMAMG00000014896wt1a10071.024Mastacembelus_armatus
ENSG00000184937WT1100100.000ENSMZEG00005012633wt1a10069.977Maylandia_zebra
ENSG00000184937WT110088.000ENSMZEG00005011978wt1b9964.172Maylandia_zebra
ENSG00000184937WT1100100.000ENSMGAG00000001489WT110094.086Meleagris_gallopavo
ENSG00000184937WT1100100.000ENSMAUG00000008036Wt110097.222Mesocricetus_auratus
ENSG00000184937WT1100100.000ENSMICG00000004097WT110099.669Microcebus_murinus
ENSG00000184937WT1100100.000ENSMOCG00000006225Wt110097.222Microtus_ochrogaster
ENSG00000184937WT110096.000ENSMMOG00000000597wt1a10067.647Mola_mola
ENSG00000184937WT110088.000ENSMMOG00000016011wt1b10062.670Mola_mola
ENSG00000184937WT1100100.000ENSMODG00000009646WT110089.333Monodelphis_domestica
ENSG00000184937WT110088.000ENSMALG00000011899wt1b9764.679Monopterus_albus
ENSG00000184937WT1100100.000ENSMALG00000005342wt1a9970.110Monopterus_albus
ENSG00000184937WT1100100.000MGP_CAROLIEiJ_G0024034Wt110098.264Mus_caroli
ENSG00000184937WT1100100.000ENSMUSG00000016458Wt110097.917Mus_musculus
ENSG00000184937WT1100100.000MGP_PahariEiJ_G0025472Wt110097.917Mus_pahari
ENSG00000184937WT1100100.000MGP_SPRETEiJ_G0024947Wt110098.264Mus_spretus
ENSG00000184937WT1100100.000ENSMPUG00000011307WT110098.845Mustela_putorius_furo
ENSG00000184937WT1100100.000ENSMLUG00000027523WT110093.364Myotis_lucifugus
ENSG00000184937WT1100100.000ENSNGAG00000022234Wt110099.306Nannospalax_galili
ENSG00000184937WT110088.000ENSNBRG00000007171wt1b9960.137Neolamprologus_brichardi
ENSG00000184937WT1100100.000ENSNLEG00000017890-10099.669Nomascus_leucogenys
ENSG00000184937WT1100100.000ENSOPRG00000015709WT110098.339Ochotona_princeps
ENSG00000184937WT17994.779ENSODEG00000015471-10094.779Octodon_degus
ENSG00000184937WT1100100.000ENSONIG00000011043wt1a10069.518Oreochromis_niloticus
ENSG00000184937WT110088.000ENSONIG00000005545wt1b9863.554Oreochromis_niloticus
ENSG00000184937WT15067.213ENSOANG00000031546-98100.000Ornithorhynchus_anatinus
ENSG00000184937WT1100100.000ENSOANG00000015147-10094.340Ornithorhynchus_anatinus
ENSG00000184937WT1100100.000ENSOCUG00000005882WT110098.977Oryctolagus_cuniculus
ENSG00000184937WT110096.000ENSORLG00000012424wt110069.604Oryzias_latipes
ENSG00000184937WT110084.000ENSORLG00000009859wt19860.820Oryzias_latipes
ENSG00000184937WT110096.000ENSORLG00020018844wt110069.147Oryzias_latipes_hni
ENSG00000184937WT110084.000ENSORLG00020005212wt1b9861.468Oryzias_latipes_hni
ENSG00000184937WT110096.000ENSORLG00015009813wt1a10069.365Oryzias_latipes_hsok
ENSG00000184937WT110084.000ENSORLG00015003298wt1b9861.048Oryzias_latipes_hsok
ENSG00000184937WT110084.000ENSOMEG00000003946wt1b9861.048Oryzias_melastigma
ENSG00000184937WT110096.000ENSOMEG00000012831wt1a10070.946Oryzias_melastigma
ENSG00000184937WT1100100.000ENSOGAG00000007118WT110097.921Otolemur_garnettii
ENSG00000184937WT1100100.000ENSOARG00000016334WT18496.306Ovis_aries
ENSG00000184937WT1100100.000ENSPPAG00000033782-10099.669Pan_paniscus
ENSG00000184937WT1100100.000ENSPPRG00000022915WT1100100.000Panthera_pardus
ENSG00000184937WT1100100.000ENSPTIG00000007474WT110091.060Panthera_tigris_altaica
ENSG00000184937WT1100100.000ENSPTRG00000003476WT110099.669Pan_troglodytes
ENSG00000184937WT1100100.000ENSPANG00000019482WT110099.669Papio_anubis
ENSG00000184937WT110096.000ENSPKIG00000023518wt1a10067.342Paramormyrops_kingsleyae
ENSG00000184937WT1100100.000ENSPSIG00000013679WT110087.037Pelodiscus_sinensis
ENSG00000184937WT110084.000ENSPMGG00000000235wt1b9757.658Periophthalmus_magnuspinnatus
ENSG00000184937WT110096.000ENSPMGG00000010507wt1a10068.653Periophthalmus_magnuspinnatus
ENSG00000184937WT1100100.000ENSPEMG00000001292Wt110097.222Peromyscus_maniculatus_bairdii
ENSG00000184937WT110088.000ENSPMAG00000008950wt1a10055.814Petromyzon_marinus
ENSG00000184937WT110076.000ENSPFOG00000017089wt1b9762.415Poecilia_formosa
ENSG00000184937WT110092.000ENSPFOG00000010572wt1a9962.526Poecilia_formosa
ENSG00000184937WT110092.000ENSPLAG00000010715wt1a10068.694Poecilia_latipinna
ENSG00000184937WT110076.000ENSPLAG00000009581wt1b9762.415Poecilia_latipinna
ENSG00000184937WT110076.000ENSPMEG00000010435wt1b9762.415Poecilia_mexicana
ENSG00000184937WT110092.000ENSPMEG00000022279wt1a10068.694Poecilia_mexicana
ENSG00000184937WT110092.000ENSPREG00000001322wt1a9364.740Poecilia_reticulata
ENSG00000184937WT110076.000ENSPREG00000013693wt1b8462.500Poecilia_reticulata
ENSG00000184937WT1100100.000ENSPPYG00000029822-10099.688Pongo_abelii
ENSG00000184937WT1100100.000ENSPCAG00000002213WT19993.810Procavia_capensis
ENSG00000184937WT1100100.000ENSPCOG00000020436WT110098.689Propithecus_coquereli
ENSG00000184937WT1100100.000ENSPVAG00000006895WT110099.617Pteropus_vampyrus
ENSG00000184937WT110088.000ENSPNYG00000018035wt1b9960.137Pundamilia_nyererei
ENSG00000184937WT1100100.000ENSPNYG00000009087wt1a10067.120Pundamilia_nyererei
ENSG00000184937WT110088.000ENSPNAG00000019996wt1b9863.182Pygocentrus_nattereri
ENSG00000184937WT1100100.000ENSPNAG00000007577wt1a10073.349Pygocentrus_nattereri
ENSG00000184937WT1100100.000ENSRNOG00000013074Wt110097.550Rattus_norvegicus
ENSG00000184937WT1100100.000ENSRBIG00000039095WT110098.689Rhinopithecus_bieti
ENSG00000184937WT1100100.000ENSRROG00000021147WT110098.689Rhinopithecus_roxellana
ENSG00000184937WT1100100.000ENSSBOG00000020662WT110099.200Saimiri_boliviensis_boliviensis
ENSG00000184937WT1100100.000ENSSHAG00000017390WT19595.789Sarcophilus_harrisii
ENSG00000184937WT1100100.000ENSSFOG00015022275wt1a10065.766Scleropages_formosus
ENSG00000184937WT1100100.000ENSSMAG00000016064wt1a10068.996Scophthalmus_maximus
ENSG00000184937WT110088.000ENSSMAG00000002419wt1b9963.571Scophthalmus_maximus
ENSG00000184937WT110088.000ENSSDUG00000020629wt1b9863.739Seriola_dumerili
ENSG00000184937WT1100100.000ENSSDUG00000004388wt1a10072.072Seriola_dumerili
ENSG00000184937WT110088.000ENSSLDG00000025654wt1b9863.964Seriola_lalandi_dorsalis
ENSG00000184937WT1100100.000ENSSLDG00000007801wt1a10071.847Seriola_lalandi_dorsalis
ENSG00000184937WT1100100.000ENSSARG00000000207WT110098.007Sorex_araneus
ENSG00000184937WT1100100.000ENSSPUG00000004548WT110085.484Sphenodon_punctatus
ENSG00000184937WT110088.000ENSSPAG00000005131wt1b9865.079Stegastes_partitus
ENSG00000184937WT1100100.000ENSSPAG00000017648wt1a10064.978Stegastes_partitus
ENSG00000184937WT1100100.000ENSSSCG00000013316WT110098.605Sus_scrofa
ENSG00000184937WT1100100.000ENSTGUG00000004906WT110086.636Taeniopygia_guttata
ENSG00000184937WT110092.000ENSTRUG00000003418-10058.427Takifugu_rubripes
ENSG00000184937WT110084.000ENSTRUG00000006559wt1b9859.637Takifugu_rubripes
ENSG00000184937WT110084.000ENSTNIG00000013806wt1b10060.544Tetraodon_nigroviridis
ENSG00000184937WT110092.000ENSTNIG00000007794wt1a10065.237Tetraodon_nigroviridis
ENSG00000184937WT1100100.000ENSTBEG00000007282-10080.986Tupaia_belangeri
ENSG00000184937WT1100100.000ENSTTRG00000012819WT110098.810Tursiops_truncatus
ENSG00000184937WT1100100.000ENSUAMG00000018139WT110098.689Ursus_americanus
ENSG00000184937WT1100100.000ENSUMAG00000019514WT110093.811Ursus_maritimus
ENSG00000184937WT1100100.000ENSVPAG00000007788WT110098.671Vicugna_pacos
ENSG00000184937WT1100100.000ENSVVUG00000016328WT110099.556Vulpes_vulpes
ENSG00000184937WT1100100.000ENSXETG00000008172wt110068.018Xenopus_tropicalis
ENSG00000184937WT110092.000ENSXCOG00000020638wt1a10069.128Xiphophorus_couchianus
ENSG00000184937WT110092.000ENSXMAG00000029371wt1a10069.128Xiphophorus_maculatus
ENSG00000184937WT110076.000ENSXMAG00000014221wt1b9762.642Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000122negative regulation of transcription by RNA polymerase II7585606.IDAProcess
GO:0000122negative regulation of transcription by RNA polymerase II23042785.IMPProcess
GO:0000981DNA-binding transcription factor activity, RNA polymerase II-specific21873635.IBAFunction
GO:0000981DNA-binding transcription factor activity, RNA polymerase II-specific-ISAFunction
GO:0000981DNA-binding transcription factor activity, RNA polymerase II-specific19274049.ISMFunction
GO:0000981DNA-binding transcription factor activity, RNA polymerase II-specific19274049.NASFunction