EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
29904245Prognostic value of hypoxia-inducible factor-1 alpha and prolyl 4-hydroxylase beta polypeptide overexpression in gastric cancer.World J Gastroenterol2018 Jun 14Zhang Jdoi: 10.3748/wjg.v24.i22.2381.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1781846578Nonsense_MutationnovelE303*0.17
BLCAchr1781855263Missense_MutationNAS168F0.23
BLCAchr1781845629Missense_MutationNAE431Q0.14
BLCAchr1781855501SilentnovelA146A0.48
BLCAchr1781859389Splice_SitenovelX49_splice0.16
BLCAchr1781844019Missense_MutationNAE507G0.58
BLCAchr1781859323SilentNAL70L0.13
BLCAchr1781847323Missense_MutationnovelE217K0.75
BLCAchr1781845591SilentNAL443L0.44
BLCAchr1781855515Missense_MutationnovelD142N0.21
BLCAchr17818439263'UTRnovel0.28
BRCAchr1781845151Missense_MutationNAD480V0.43
BRCAchr1781859323SilentnovelL70L0.48
BRCAchr1781845959Missense_MutationNAD363E0.41
BRCAchr1781845885Missense_MutationnovelV388G0.44
CESCchr1781847323Missense_MutationnovelE217Q0.24
CESCchr1781845224Missense_MutationnovelD456H0.06
COADchr1781846534Silentrs765631122L317L0.32
COADchr1781855192Missense_MutationnovelV192M0.26
COADchr17818438253'UTRrs5611389490.5
COADchr1781845888Frame_Shift_Delrs773547908N387Tfs*1180.25
COADchr17818437013'UTRnovel0.5
COADchr1781846626Missense_MutationNAL287M0.36
COADchr1781859273Missense_MutationnovelE87V0.39
COADchr1781845634Missense_MutationnovelA429V0.14
COADchr1781845143Splice_SiteNAX482_splice0.28
COADchr1781845616Missense_MutationnovelV435G0.57
COADchr1781845724Missense_MutationnovelH399R0.2
COADchr1781855273Missense_MutationnovelE165K0.13
COADchr1781845654Silentrs184374096I422I0.33
ESCAchr1781855586Missense_MutationnovelA118G0.17
GBMchr1781845933Missense_MutationnovelL372P0.08
GBMchr1781855457Missense_MutationnovelF161C0.31
GBMchr1781846612Silentrs151018460I291I0.17
GBMchr1781846996Missense_MutationnovelD269G0.14
GBMchr1781855537SilentnovelG134G0.19
GBMchr1781845573Missense_MutationnovelS449R0.09
GBMchr1781846612Silentrs151018460I291I0.49
GBMchr1781855233Missense_MutationnovelA178G0.09
GBMchr1781844030SilentnovelA503A0.07
GBMchr1781845631Missense_MutationnovelN430S0.21
HNSCchr1781855171Missense_MutationNAD199H0.25
HNSCchr1781855193Silentrs141223466D191D0.3
HNSCchr17818438013'UTRnovel0.43
HNSCchr1781846480Silentrs201567654T335T0.26
KICHchr1781844014Frame_Shift_Delnovel*509I0.29
LGGchr1781845174Silentrs201834939S472S0.43
LIHCchr17818604885'UTRnovel0.11
LUADchr1781846483SilentNAL334L0.17
LUADchr1781847333SilentnovelR213R0.14
LUADchr1781859388Splice_SiteNAX49_splice0.19
LUADchr1781855193Silentrs141223466D191D0.28
LUADchr1781859286Missense_MutationnovelD83H0.07
LUADchr1781844048Missense_MutationnovelE497D0.21
LUADchr1781845564Missense_MutationNAR452S0.24
LUADchr1781845595Missense_MutationnovelT442I0.21
LUADchr1781855160SilentNAG202G0.15
LUSCchr1781846543Silentrs199705471A314A0.21
LUSCchr1781847283Missense_Mutationrs773105281K230R0.24
LUSCchr1781845563Missense_MutationNAT453A0.3
LUSCchr1781844077Missense_MutationNAE488Q0.27
LUSCchr1781844073Missense_Mutationrs148124283E489A0.22
LUSCchr1781844074Nonsense_MutationNAE489*0.23
LUSCchr1781845657SilentNAV421V0.21
OVchr1781855274SilentnovelV164V0.04
OVchr17818439713'UTRnovel0.14
OVchr1781855203Missense_MutationNAS188F0.05
OVchr1781855483SilentnovelS152S0.05
OVchr1781855484Missense_Mutationrs771212950S152F0.05
OVchr1781855142Missense_MutationnovelK208N0.06
OVchr1781855535Missense_MutationnovelP135R0.33
OVchr1781859181Missense_MutationnovelA118T0.06
OVchr1781846587Missense_MutationnovelR300C0.18
OVchr1781847053Missense_MutationnovelG250A0.11
PAADchr17818439873'UTRnovel0.33
PRADchr1781845910Missense_Mutationrs759952074V380M0.46
READchr1781855540Silentrs370423809T133T0.34
SKCMchr1781845619Missense_MutationNAA434V0.45
SKCMchr17818438603'UTRnovel0.41
SKCMchr17818438593'UTRrs2019103690.54
SKCMchr1781845228Splice_RegionNAV454V0.09
SKCMchr1781855206Missense_MutationNAT187I0.07
SKCMchr1781846468SilentnovelI339I0.6
SKCMchr1781846498Silentrs747026364P329P0.46
SKCMchr1781846510SilentNAT325T0.05
SKCMchr1781847243Splice_RegionNAQ243Q0.32
SKCMchr1781847313Missense_MutationNAV220A0.13
STADchr1781845888Frame_Shift_Delrs773547908N387Tfs*1180.27
STADchr1781845561Splice_RegionNAT453T0.33
STADchr1781855172SilentnovelL198L0.27
STADchr17818440093'UTRrs3706880040.16
STADchr1781845888Frame_Shift_Delrs773547908N387Tfs*1180.33
STADchr1781845207SilentNAR461R0.26
STADchr1781845573SilentnovelS449S0.15
STADchr1781846586Missense_MutationNAR300H0.15
STADchr1781855492SilentnovelL149L0.13
STADchr1781845888Frame_Shift_Delrs773547908N387Tfs*1180.32
STADchr1781845888Frame_Shift_Delrs773547908N387Tfs*1180.33
STADchr1781846508Missense_MutationNAK326R0.1
STADchr17818438903'UTRnovel0.27
STADchr1781845681Silentrs200433403T413T0.19
STADchr1781846536Missense_MutationNAL317F0.12
THCAchr1781846524Missense_MutationNAE321Q0.25
THYMchr1781846536Missense_MutationnovelL317I0.13
UCECchr1781847249Silentrs142657365T241T0.46
UCECchr1781859221Missense_MutationNAF104L0.21
UCECchr1781845640Missense_Mutationrs371414493S427L0.34
UCECchr1781847064SilentNAP246P0.43
UCECchr17818439323'UTRnovel0.5
UCECchr1781859299SilentnovelR78R0.44
UCECchr1781845872Missense_MutationnovelF392L0.26
UCECchr1781845203Missense_Mutationrs757142554L463M0.22
UCECchr1781844023Missense_MutationNAD506Y0.28
UCECchr1781844054Missense_MutationnovelM495I0.1
UCECchr1781847315Missense_MutationnovelE219D0.1
UCECchr1781845888Frame_Shift_Delrs773547908N387Tfs*1180.36
UCECchr17818439463'UTRnovel0.41
UCECchr1781846586Missense_MutationNAR300H0.15
UCECchr1781855540Silentrs370423809T133T0.27
UCECchr1781845888Frame_Shift_Delrs773547908N387Tfs*1180.45
UCECchr1781845208Missense_Mutationrs769747717R461H0.28
UCECchr1781845888Frame_Shift_Delrs773547908N387Tfs*1180.37
UCECchr1781846538Missense_Mutationrs776010531R316H0.37
UCECchr1781846459SilentnovelF342F0.36
UCECchr1781855240Missense_MutationnovelA176T0.1
UCECchr1781845888Frame_Shift_Delrs773547908N387Tfs*1180.32
UCECchr1781859204Missense_Mutationrs760119422T110M0.46
UCECchr1781859247Missense_MutationNAV96M0.24
UCECchr1781845659Missense_Mutationrs573703484V421I0.38
UCECchr17818439773'UTRnovel0.22
UCECchr1781859221Missense_MutationNAF104L0.52
UCECchr17818439063'UTRnovel0.15
UCECchr1781847073Splice_SitenovelX244_splice0.35

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCAAMP0.39220.00012456
CESCDEL0.10510.00067839
KIRPAMP0.67010.14801
LGGAMP0.06631.52e-05
SARCAMP0.19840.032181
SKCMAMP0.28347.0388e-08
THCADEL0.0020.221
UVMAMP0.16250.054583

Survival Analysis
CancerP-value Q-value
KIRC0.00043

Kaplan-Meier Survival Analysis

ACC0.00072

Kaplan-Meier Survival Analysis

PRAD0.024

Kaplan-Meier Survival Analysis

KIRP0.0001

Kaplan-Meier Survival Analysis

COAD0.017

Kaplan-Meier Survival Analysis

BLCA0.00036

Kaplan-Meier Survival Analysis

CESC0.0094

Kaplan-Meier Survival Analysis

KICH0.0036

Kaplan-Meier Survival Analysis

UCEC0.0063

Kaplan-Meier Survival Analysis

GBM0.0021

Kaplan-Meier Survival Analysis

THCA0.049

Kaplan-Meier Survival Analysis

UVM0.00039

Kaplan-Meier Survival Analysis

OV0.016

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000185624 (Gene tree)
Gene ID
5034
Gene Symbol
P4HB
Alias
PDIA1|PROHB|DSI|GIT|PDI|PO4HB|P4Hbeta|PO4DB|ERBA2L
Full Name
prolyl 4-hydroxylase subunit beta
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
17,537 bases
Position
chr17:81,843,158-81,860,694
Accession
8548
RBP type
non-canonical RBP
Summary
This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
8455607Relatedness of an RNA-binding motif in human immunodeficiency virus type 1 TAR RNA-binding protein TRBP to human P1/dsI kinase and Drosophila staufen.Mol Cell Biol1993 AprGatignol A-
21357685Glucose-stimulated translation regulation of insulin by the 5' UTR-binding proteins.J Biol Chem2011 Apr 22Kulkarni SDdoi: 10.1074/jbc.M110.190553
11950970The rice mutant esp2 greatly accumulates the glutelin precursor and deletes the protein disulfide isomerase.Plant Physiol2002 AprTakemoto Y-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000476482P4HB-210765--- (aa)--
ENST00000576380P4HB-222943-ENSP00000460285200 (aa)-I3L398
ENST00000477607P4HB-2111110--- (aa)--
ENST00000478034P4HB-212811--- (aa)--
ENST00000570907P4HB-214353-ENSP00000461362117 (aa)-I3L4M2
ENST00000415593P4HB-2021669-ENSP00000388117274 (aa)-H0Y3Z3
ENST00000576541P4HB-224571-ENSP00000460741188 (aa)-I3L3U6
ENST00000439918P4HB-2031502-ENSP00000388374464 (aa)-H7BZ94
ENST00000571617P4HB-216505-ENSP00000458300148 (aa)-I3L0S0
ENST00000576052P4HB-221562-ENSP00000461791166 (aa)-I3NI03
ENST00000576390P4HB-223439-ENSP00000461718106 (aa)-I3L514
ENST00000484286P4HB-213759--- (aa)--
ENST00000574914P4HB-219571-ENSP00000460612156 (aa)-I3L3P5
ENST00000575069P4HB-2202453-ENSP0000045921154 (aa)-I3L1Y5
ENST00000573778P4HB-217688-ENSP00000460088208 (aa)-I3L312
ENST00000466567P4HB-204872--- (aa)--
ENST00000574007P4HB-2181053--- (aa)--
ENST00000471535P4HB-206579--- (aa)--
ENST00000467086P4HB-205785--- (aa)--
ENST00000472244P4HB-207858--- (aa)--
ENST00000571507P4HB-215493--- (aa)--
ENST00000331483P4HB-2012603XM_024450777ENSP00000327801508 (aa)XP_024306545P07237
ENST00000473021P4HB-208914--- (aa)--
ENST00000474712P4HB-209390--- (aa)--
Gene Model
Click here to download ENSG00000185624's gene model file
Pathways
Pathway IDPathway NameSource
hsa04141Protein processing in endoplasmic reticulumKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000185624's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000185624P4HB9794.534ENSMUSG00000025130P4hb9094.989Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0003756protein disulfide isomerase activity15720785.EXPFunction
GO:0003756protein disulfide isomerase activity21873635.IBAFunction
GO:0003756protein disulfide isomerase activity15225124.IDAFunction
GO:0004656procollagen-proline 4-dioxygenase activity7753822.IDAFunction
GO:0005178integrin binding21670307.IPIFunction
GO:0005515protein binding12095988.17055437.19942855.20802462.21057456.21670307.23475612.23861867.25108285.26224785.IPIFunction
GO:0005576extracellular region14718574.NASComponent
GO:0005783endoplasmic reticulum21873635.IBAComponent
GO:0005783endoplasmic reticulum12095988.23152784.23475612.IDAComponent
GO:0005788endoplasmic reticulum lumen-TASComponent
GO:0005793endoplasmic reticulum-Golgi intermediate compartment15308636.IDAComponent
GO:0005925focal adhesion21423176.HDAComponent
GO:0006457protein folding21873635.IBAProcess
GO:0009897external side of plasma membrane21873635.IBAComponent
GO:0009897external side of plasma membrane21670307.IDAComponent
GO:0015037peptide disulfide oxidoreductase activity16677074.IDAFunction
GO:0016222procollagen-proline 4-dioxygenase complex7753822.IDAComponent
GO:0018401peptidyl-proline hydroxylation to 4-hydroxy-L-proline7753822.IDAProcess
GO:0019899enzyme binding-IEAFunction
GO:0034378chylomicron assembly-TASProcess
GO:0034379very-low-density lipoprotein particle assembly-TASProcess
GO:0034663endoplasmic reticulum chaperone complex-IEAComponent
GO:0034976response to endoplasmic reticulum stress21873635.IBAProcess
GO:0034976response to endoplasmic reticulum stress12095988.IMPProcess
GO:0035722interleukin-12-mediated signaling pathway-TASProcess
GO:0038155interleukin-23-mediated signaling pathway-TASProcess
GO:0042470melanosome-IEAComponent
GO:0043687post-translational protein modification-TASProcess
GO:0044267cellular protein metabolic process-TASProcess
GO:0045454cell redox homeostasis-IEAProcess
GO:0046598positive regulation of viral entry into host cell21670307.IMPProcess
GO:0046982protein heterodimerization activity23475612.IDAFunction
GO:0055114oxidation-reduction process-IEAProcess
GO:0070062extracellular exosome19199708.HDAComponent
GO:0071456cellular response to hypoxia12095988.IMPProcess
GO:0098761cellular response to interleukin-7-IEAProcess
GO:1902175regulation of oxidative stress-induced intrinsic apoptotic signaling pathway12095988.IMPProcess
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